Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMJOZD)

• Drug Name: ANW-32821 Drug Info
• Synonyms: Cholest-5-en-3-beta-ol; Cholesterol; Cholest-5-en-3-ol (3beta)-; Cholest-5-en-3beta-ol; Cholesterin; Cholesterine; Cholesterol base H; Cholesteryl alcohol; Cholestrin; Cholestrol; Cordulan; Dastar; Dusoline; Dusoran; Dythol; Hydrocerin; Kathro; Lidinit; Lidinite; Nimco cholesterol base H; Provitamin D; Super hartolan; Tegolan; Tegolan (VAN); Wool alcohols B. P.; cholesterol; (-)-Cholesterol; (3beta)-cholest-5-en-3-ol; 3-beta-Hydroxycholest-5-ene; 3beta-Hydroxycholest-5-ene; 5-Cholesten-3beta-ol; 57-88-5; 5:6-Cholesten-3beta-ol; CCRIS 2834; Lanol
• Cross-matching ID:
  PubChem CID: 5997
  ChEBI ID: ChEBI:15372
  CAS Number: CAS 17528-72-2
  TTD Drug ID: DMMJOZD
  INTEDE Drug ID: DR2314

Molecule-Related Drug Atlas

Drug(s) Metabolized By Vitamin D(3) 25-hydroxylase (CYP27A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxercalciferol	DM6FG1P	Chronic kidney disease	GB61	Approved	[11]
Vitamin D	DMWQUC9	N. A.	N. A.	Approved	[12]
Alfacalcidol	DM1237M	Hyperparathyroidism	5A51	Phase 4	[13]

Drug(s) Metabolized By Cholesterol 24-hydroxylase (CYP46A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[14]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[14]
Dextromethorphan	DMUDJZM	Allergic rhinitis	CA08.0	Approved	[14]
Testosterone cypionate	DMC1TEV	N. A.	N. A.	Approved	[14]
Phenacetin	DMRQAM0	Analgesia	MB40.8	Withdrawn from market	[14]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[14]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[14]
Dextromethorphan	DMUDJZM	Allergic rhinitis	CA08.0	Approved	[14]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[29]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[14]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[30]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[31]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[32]

Drug(s) Metabolized By Cholesterol desmolase (CYP11A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ergocalciferol	DMHO0AR	Hypoparathyroidism	5A50	Approved	[15]
Vitamin D	DMWQUC9	N. A.	N. A.	Approved	[16]

Drug(s) Metabolized By Cytochrome P450 7A1 (CYP7A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bile acid	DM9UZD7	Discovery agent	N.A.	Phase 1	[17]

Drug(s) Affected By Sterol 26-hydroxylase, mitochondrial (CYP27A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[18]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[20]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[21]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[22]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[26]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[27]

Drug(s) Affected By Liver carboxylesterase 1 (CES1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[33]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[34]
Dextropropoxyphene	DM23HCX	Pain	MG30-MG3Z	Approved	[35]
Selenium	DM25CGV	N. A.	N. A.	Approved	[36]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[39]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[40]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]

Drug(s) Affected By 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[43]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[44]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[45]
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[46]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[47]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[48]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[50]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[20]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[51]

Drug(s) Affected By Aquaporin-9 (AQP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[54]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[52]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[55]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[56]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[57]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[58]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[59]

Drug(s) Affected By E3 ubiquitin-protein ligase MARCHF6 (MARCHF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[36]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Betaine	DMGRZW2	Cystitis	GC00	Approved	[60]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[61]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[62]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[29]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[63]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[36]
CB-5083	DM12GN7	Multiple myeloma	2A83	Phase 1	[60]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[64]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[65]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[66]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[67]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[68]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[67]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[69]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[71]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[72]

Drug(s) Affected By Lipoprotein lipase (LPL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[46]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[73]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[75]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[78]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[79]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[80]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[79]

Drug(s) Affected By Platelet glycoprotein Ib alpha chain (GP1BA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[81]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[82]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[83]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[84]

Drug(s) Affected By Cathepsin B (CTSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[85]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[86]
Selenium	DM25CGV	N. A.	N. A.	Approved	[36]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[87]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Pyrimethamine	DM5X7VY	Malaria	1F40-1F45	Approved	[88]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[89]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[90]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[91]

Drug(s) Affected By Inhibin beta A chain (INHBA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[92]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[41]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[96]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[97]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[81]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[98]

Drug(s) Affected By Macrophage colony-stimulating factor 1 (CSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[99]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[101]
Selenium	DM25CGV	N. A.	N. A.	Approved	[36]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[103]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[104]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[105]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[93]

Drug(s) Affected By Lysosome-associated membrane glycoprotein 1 (LAMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[106]
Selenium	DM25CGV	N. A.	N. A.	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[108]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[111]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[106]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[112]

Drug(s) Affected By C-C motif chemokine 4 (CCL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[113]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[116]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[118]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[54]

Drug(s) Affected By Amphiregulin (AREG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[120]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[121]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[47]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[122]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[124]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[125]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[126]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[127]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[128]

Drug(s) Affected By Vascular endothelial growth factor receptor 1 (FLT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[130]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[132]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[24]
Haloperidol	DM96SE0	Delirium		Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[133]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[54]

Drug(s) Affected By Interleukin-1 receptor antagonist protein (IL1RN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[134]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[135]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[78]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[137]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[138]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[93]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[140]

Drug(s) Affected By Kit ligand (KITLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[141]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[130]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[145]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[146]

Drug(s) Affected By C-C motif chemokine 1 (CCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[147]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[54]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[148]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[149]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[150]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[59]
ACYLINE	DM9GRTK	Prostate cancer	2C82.0	Phase 2	[151]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[152]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[153]
Nickel chloride	DMI12Y8	Discovery agent	N.A.	Investigative	[154]

Drug(s) Affected By Metalloproteinase inhibitor 3 (TIMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[155]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[156]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[157]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[158]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[160]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[93]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]

Drug(s) Affected By Regulator of G-protein signaling 2 (RGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[161]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[127]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[163]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[164]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[165]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[166]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[167]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[168]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[169]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[170]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[171]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[172]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[173]

Drug(s) Affected By Excitatory amino acid transporter 1 (SLC1A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[130]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[174]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[175]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[97]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[176]

Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[177]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[178]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Selenium	DM25CGV	N. A.	N. A.	Approved	[36]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[180]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[181]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[182]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[183]

Drug(s) Affected By P2X purinoceptor 1 (P2RX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[184]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[185]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[186]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[187]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[188]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[32]

Drug(s) Affected By Oxysterols receptor LXR-beta (NR1H2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[189]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[190]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Gemfibrozil	DMD8Q3J	Hyperlipidaemia	5C80	Approved	[191]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[191]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[192]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[193]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[191]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[194]

Drug(s) Affected By Small ribosomal subunit protein eS6 (RPS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[195]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[122]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[196]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[197]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[198]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[199]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[200]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[109]
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[201]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]

Drug(s) Affected By Large neutral amino acids transporter small subunit 1 (SLC7A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[125]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[202]
Selenium	DM25CGV	N. A.	N. A.	Approved	[36]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[203]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[204]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[159]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[130]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[205]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[125]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[206]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[207]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[208]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[209]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[210]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[157]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[211]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[212]

Drug(s) Affected By Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[213]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[214]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[215]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[216]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[217]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[200]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[218]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[146]

Drug(s) Affected By Squalene monooxygenase (SQLE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[60]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[50]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[93]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[146]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[220]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[221]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[222]
Artemether	DM48QOT	Malaria	1F40-1F45	Approved	[223]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[103]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[225]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[226]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[227]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]

Drug(s) Affected By Type II iodothyronine deiodinase (DIO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[120]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[228]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[230]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[96]
Ergocalciferol	DMHO0AR	Hypoparathyroidism	5A50	Approved	[231]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[175]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[193]

Drug(s) Affected By Transmembrane 4 L6 family member 19 (TM4SF19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[193]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[232]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[233]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[29]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[234]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[235]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[236]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[237]

Drug(s) Affected By Proheparin-binding EGF-like growth factor (HBEGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[238]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[239]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[240]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[21]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[21]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[241]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[41]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[127]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[105]

Drug(s) Affected By Osteoclast stimulatory transmembrane protein (OCSTAMP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[139]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[59]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[188]

Drug(s) Affected By Normal mucosa of esophagus-specific gene 1 protein (C15ORF48)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[78]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[192]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[175]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[242]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[59]

Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[207]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[243]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[157]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[103]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[108]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[246]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[247]

Drug(s) Affected By Dendritic cell-specific transmembrane protein (DCSTAMP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[248]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[81]
Methamphetamine	DMPM4SK	Anxiety		Approved	[249]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[235]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[236]
PMID27336223-Compound-5	DM6E50A	N. A.	N. A.	Patented	[248]

Drug(s) Affected By Regulator of cell cycle RGCC (RGCC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[250]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[49]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[251]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[252]

Drug(s) Affected By Solute carrier family 28 member 3 (SLC28A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[204]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[78]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[175]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[186]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[253]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[253]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[254]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[236]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[255]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[256]

Drug(s) Affected By C-type lectin domain family 5 member A (CLEC5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[184]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[257]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[188]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[258]
Nickel chloride	DMI12Y8	Discovery agent	N.A.	Investigative	[257]

Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[259]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[259]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[260]
Sunitinib	DMCBJSR	Acute undifferentiated leukemia		Approved	[46]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[261]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[262]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[263]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[264]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[204]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[265]

Drug(s) Affected By Phosphoserine aminotransferase (PSAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[266]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[267]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[78]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[266]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[268]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[268]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[140]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[269]

Drug(s) Affected By ATP-binding cassette sub-family G member 5 (ABCG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[18]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[270]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[271]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[270]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[192]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[232]

Drug(s) Affected By Apolipoprotein A-I (APOA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[272]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[273]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[20]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[274]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[275]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[276]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[277]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[269]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[278]

Drug(s) Affected By C-type lectin domain family 4 member E (CLEC4E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[279]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[280]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[175]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[232]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[281]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[237]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[282]
desmosterol	DMV8SUM	Discovery agent	N.A.	Investigative	[7]

Drug(s) Affected By Phospholipid-transporting ATPase ABCA1 (ABCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[283]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[50]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[20]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[284]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[285]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[271]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[286]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[287]

Drug(s) Affected By Sterol regulatory element-binding protein 2 (SREBF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[46]
Selenium	DM25CGV	N. A.	N. A.	Approved	[36]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[288]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[20]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[289]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[127]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[190]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[290]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[140]

Drug(s) Affected By Serum paraoxonase/arylesterase 1 (PON1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[291]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[292]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[293]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[294]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[295]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[296]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[130]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[297]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[275]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[291]

Drug(s) Affected By Caveolin-1 (CAV1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[298]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[73]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[299]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[300]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[301]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[262]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[302]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[163]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]

Drug(s) Affected By Steroidogenic acute regulatory protein, mitochondrial (STAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[303]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[92]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[304]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[140]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[305]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[306]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[307]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[308]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[96]

Drug(s) Affected By Squalene synthase (FDFT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[309]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[159]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[139]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[310]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[269]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]

Drug(s) Affected By Low-density lipoprotein receptor (LDLR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[311]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[47]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[311]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[312]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[44]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[20]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[212]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[159]

Drug(s) Affected By Sigma intracellular receptor 2 (TMEM97)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[211]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[92]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[175]

Drug(s) Affected By Mevalonate kinase (MVK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[36]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[18]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[50]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[20]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[159]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[313]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[97]

Drug(s) Affected By ATP-binding cassette sub-family G member 8 (ABCG8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[271]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[314]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[315]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[316]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[317]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]

Drug(s) Affected By 7-dehydrocholesterol reductase (DHCR7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[36]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[318]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[50]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[20]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[159]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[319]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[320]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[24]

Drug(s) Affected By Insulin receptor substrate 1 (IRS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[321]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[92]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[322]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[93]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]

Drug(s) Affected By Advanced glycosylation end product-specific receptor (AGER)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[323]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
TRIENTINE	DMD2WPG	Inborn error of metabolism	5C50-5C59	Approved	[324]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[325]
Mebendazole	DMO14SG	Ascariasis	1F62	Approved	[326]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[327]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[327]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[325]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[328]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[329]

Drug(s) Affected By NPC intracellular cholesterol transporter 1 (NPC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[210]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[280]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[110]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[330]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[193]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[232]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[58]

Drug(s) Affected By Phosphatidylcholine-sterol acyltransferase (LCAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[202]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[20]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[276]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[140]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[331]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[232]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[332]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[332]

Drug(s) Affected By Fibroblast growth factor receptor 4 (FGFR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[20]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[334]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[23]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[25]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[280]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[175]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[335]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[232]

Drug(s) Affected By Caveolin-3 (CAV3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[336]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[337]
Phenylephrine	DMZHUO5	Allergic rhinitis	CA08.0	Approved	[338]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[32]

Molecular Interaction Atlas of This Drug

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cholesterol desmolase (CYP11A1)	DE98XPV	CP11A_HUMAN	Substrate	[1]
Vitamin D(3) 25-hydroxylase (CYP27A1)	DEBS639	CP27A_HUMAN	Substrate	[1]
Cholesterol 24-hydroxylase (CYP46A1)	DEKP5HX	CP46A_HUMAN	Substrate	[1]
Cytochrome P450 142A2 (cyp142)	DEPUK4S	CP142_MYCS2	Substrate	[2]
Cytochrome P450 125A3 (cyp125)	DE6ZDK4	CP125_MYCS2	Substrate	[2]
Cytochrome P450 142A1 (cyp142)	DEMQ20F	CP142_MYCTU	Substrate	[3]
Cytochrome P450 125A1 (cyp125)	DELIXR8	CP125_MYCTU	Substrate	[3]
Cytochrome P450 7A1 (CYP7A1)	DEDZRQ1	CP7A1_HUMAN	Substrate	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)	OTRT3F3U	HMDH_HUMAN	Gene/Protein Processing	[4]
7-dehydrocholesterol reductase (DHCR7)	OTLILBUI	DHCR7_HUMAN	Regulation of Drug Effects	[5]
Advanced glycosylation end product-specific receptor (AGER)	OTPY0IH7	RAGE_HUMAN	Regulation of Drug Effects	[6]
Amphiregulin (AREG)	OTJFOR67	AREG_HUMAN	Gene/Protein Processing	[7]
Apolipoprotein A-I (APOA1)	OT5THARI	APOA1_HUMAN	Regulation of Drug Effects	[8]
Aquaporin-9 (AQP9)	OTLGH5ZY	AQP9_HUMAN	Gene/Protein Processing	[7]
ATP-binding cassette sub-family G member 5 (ABCG5)	OT1OMY93	ABCG5_HUMAN	Regulation of Drug Effects	[9]
ATP-binding cassette sub-family G member 8 (ABCG8)	OTIJ76XW	ABCG8_HUMAN	Regulation of Drug Effects	[9]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)	OTW8V2V1	ABCG2_HUMAN	Gene/Protein Processing	[10]
C-C motif chemokine 1 (CCL1)	OT23NON8	CCL1_HUMAN	Gene/Protein Processing	[7]

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