Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM5TQ2O)

• Drug Name: Galangin Drug Info
• Synonyms: Galangin; 548-83-4; Norizalpinin; 3,5,7-Trihydroxyflavone; 3,5,7-Trihydroxy-2-phenyl-4H-chromen-4-one; 3,5,7-triOH-Flavone; UNII-142FWE6ECS; 3,5,7-Trihydroxy-2-phenyl-4-benzopyrone; 4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-phenyl-; EINECS 208-960-4; NSC407229; FLAVONE, 3,5,7-TRIHYDROXY-; NSC 407229; NSC-407229; 4H-Benzopyran-4-one, 3,5,7-trihydroxy-2-phenyl-; BRN 0272179; 142FWE6ECS; 3,5,7-trihydroxy-2-phenylchromen-4-one; CHEBI:5262; CHEMBL309490; VCCRNZQBSJXYJD-UHFFFAOYSA-N; 3,5,7-trihydroxy-2-phenyl-4H-benzopyran-4-one

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5281616
  ChEBI ID: CHEBI:5262
  CAS Number: CAS 548-83-4
  TTD Drug ID: DM5TQ2O

Molecule-Related Drug Atlas

Drug(s) Targeting Adenosine A3 receptor (ADORA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
IB-MECA	DM9G5XD	Psoriasis vulgaris	EA90	Phase 3	[8]
Tonapofylline	DMBH316	Acute and chronic heart failure	BD1Z	Phase 2	[9]
NITD609	DMQHBSX	Malaria	1F40-1F45	Phase 2	[10]
CF102	DMP56WJ	Hepatocellular carcinoma	2C12.02	Phase 2	[11]
SCH-442416	DMQ2K1V	N. A.	N. A.	Phase 1	[12]
AST-004	DM5WMG7	Stroke	8B20	Phase 1	[13]
BEMESETRON	DMSPJX9	N. A.	N. A.	Discontinued in Phase 3	[14]
BAY 60-6583	DMTEJV1	Myocardial ischemia	BA6Z	Preclinical	[15]
CF602	DM0ULO2	Inflammation	1A00-CA43.1	Preclinical	[11]
CF502	DMQSJ20	Inflammation	1A00-CA43.1	Preclinical	[11]

Drug(s) Targeting Adenosine A2a receptor (ADORA2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Caffeine	DMKBJWP	Allergic rhinitis	CA08.0	Approved	[16]
Istradefylline	DM20VSK	Parkinson disease	8A00.0	Approved	[17]
Regadenoson	DM76VHG	Radionuclide imaging	N.A.	Approved	[18]
Tozadenant	DMATC14	Parkinson disease	8A00.0	Phase 3	[19]
Binodenoson	DMVHF8G	Hypertension	BA00-BA04	Phase 3	[20]
Apadenoson	DMD8QTC	Coronary artery disease	BA80	Phase 3	[21]
Tonapofylline	DMBH316	Acute and chronic heart failure	BD1Z	Phase 2	[9]
Dexefaroxan	DMTY4KN	Parkinson disease	8A00.0	Phase 2	[22]
AMP-579	DMJ4GPR	Hyperlipidaemia	5C80	Phase 2	[23]
BIIB014	DMH7RJ1	Parkinson disease	8A00.0	Phase 2	[24]

Drug(s) Targeting Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PINOCEMBRIN	DM96VWD	N. A.	N. A.	Phase 2	[4]
NARINGENIN	DMHAZLM	N. A.	N. A.	Phase 1	[4]
Chrysin	DM7V2LG	Discovery agent	N.A.	Investigative	[4]
APIGENIN	DMI3491	Discovery agent	N.A.	Investigative	[4]
KAEMPFEROL	DMHEMUB	Discovery agent	N.A.	Investigative	[4]
ISORHAMNETIN	DMQ4Z6E	Discovery agent	N.A.	Investigative	[4]
ACACETIN	DMQOB0X	Discovery agent	N.A.	Investigative	[4]
TRISMETHOXYRESVERATROL	DM6USPC	Discovery agent	N.A.	Investigative	[25]
CHRYSOERIOL	DM96ECL	Discovery agent	N.A.	Investigative	[4]
DIOSMETIN	DM4KXIM	Discovery agent	N.A.	Investigative	[4]

Drug(s) Affected By Glutathione S-transferase P (GSTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[28]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[28]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[29]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[30]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[31]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[33]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[34]

Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[35]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[35]
Etoricoxib	DM6A4NW	Rheumatoid arthritis	FA20	Approved	[35]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[36]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[37]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[38]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[39]
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[40]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[41]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[42]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[43]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[44]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[45]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[46]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[47]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[48]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[49]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[50]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[51]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[52]

Drug(s) Affected By Cytochrome P450 2B6 (CYP2B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[53]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[54]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[55]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[56]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[57]
Clopidogrel	DMOL54H	Acute coronary syndrome	BA41	Approved	[58]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[59]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[60]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[61]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[62]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[63]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[64]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[65]
Artemether	DM48QOT	Malaria	1F40-1F45	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[68]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[69]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[70]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[72]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[73]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[74]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[75]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[76]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[77]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[78]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[79]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[80]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[81]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[79]

Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[82]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[83]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[84]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[85]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[86]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[86]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[87]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[88]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[89]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[90]

Drug(s) Affected By Mothers against decapentaplegic homolog 7 (SMAD7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[93]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[97]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[98]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[99]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[100]

Drug(s) Affected By Mothers against decapentaplegic homolog 6 (SMAD6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[104]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[105]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[106]

Drug(s) Affected By Ubiquitin-like protein ATG12 (ATG12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[107]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[109]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[110]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[111]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[99]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[113]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[115]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[116]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[117]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[118]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[31]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[119]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[120]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[121]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[122]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[123]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[124]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[125]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[126]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[127]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[128]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[129]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[128]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[130]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[131]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[132]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[133]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[134]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[136]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[42]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[124]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[137]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[138]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[139]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[140]

Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[141]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[142]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[144]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[145]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[146]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[123]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[147]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]

Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[149]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[150]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[151]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[152]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[119]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[153]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[154]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[155]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[156]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[157]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[158]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[159]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[140]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[160]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[161]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[118]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[162]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[163]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[164]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[165]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[166]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[140]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[168]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[152]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[169]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[170]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[163]

Drug(s) Affected By Multidrug resistance-associated protein 1 (ABCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[171]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[172]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[173]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[174]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[175]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[176]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[177]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[178]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[179]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[179]

Drug(s) Affected By TGF-beta receptor type-1 (TGFBR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[180]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[181]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[182]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[183]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[184]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[185]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[185]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[186]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[187]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[188]

Drug(s) Affected By TGF-beta receptor type-2 (TGFBR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[181]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[189]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[190]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[123]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[192]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[194]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[194]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[195]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[196]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[197]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[198]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[118]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[199]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[200]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[201]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[129]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[202]

Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[203]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[180]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[150]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[151]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[204]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[163]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[207]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[111]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[208]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[209]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[210]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[211]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[212]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[213]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[214]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[215]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[216]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[217]

Drug(s) Affected By Mothers against decapentaplegic homolog 3 (SMAD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[218]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[219]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[182]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[221]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[187]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[222]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[223]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[224]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[225]

Drug(s) Affected By Cyclin-dependent kinase 6 (CDK6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[142]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[226]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[117]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[120]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[227]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[228]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[147]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[229]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[133]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[217]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[124]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[137]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[230]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[231]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[118]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[31]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[232]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[129]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[233]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[127]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[234]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[235]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[236]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[227]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[48]

Drug(s) Affected By Mothers against decapentaplegic homolog 4 (SMAD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[182]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[155]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[237]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[72]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[238]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[188]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[239]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[240]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[223]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[99]

Drug(s) Affected By Beclin-1 (BECN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[241]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[124]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[204]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[242]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[243]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[244]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[245]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[246]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[247]

Drug(s) Affected By Mothers against decapentaplegic homolog 2 (SMAD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[248]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[182]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[155]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[184]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[229]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[250]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[250]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[240]

Drug(s) Affected By Mothers against decapentaplegic homolog 1 (SMAD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[251]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[93]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[239]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[99]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[252]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[253]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[42]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[254]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[255]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[256]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[257]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[258]
Selenium	DM25CGV	N. A.	N. A.	Approved	[32]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[259]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[260]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[261]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[91]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[262]

Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[263]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[265]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[265]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[266]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[267]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[268]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[269]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[270]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[154]

Drug(s) Affected By Autophagy-related protein 16-1 (ATG16L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[218]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[110]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[187]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[271]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[99]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[272]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[253]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[273]

Drug(s) Affected By Endothelial PAS domain-containing protein 1 (EPAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[248]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[274]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[275]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[276]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[229]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[277]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[188]
Ketorolac	DMI4EL5	Postoperative inflammation	1A00-CA43.1	Approved	[277]

Drug(s) Affected By Ubiquitin-like-conjugating enzyme ATG3 (ATG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[278]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[279]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[110]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[72]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[280]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[188]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[240]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[279]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[113]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adenosine A2a receptor (ADORA2A)	TTM2AOE	AA2AR_HUMAN	Inhibitor	[2]
Adenosine A3 receptor (ADORA3)	TTJFY5U	AA3R_HUMAN	Inhibitor	[3]
Cytochrome P450 1B1 (CYP1B1)	TTI84H7	CP1B1_HUMAN	Inhibitor	[4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[5]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[5]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Gene/Protein Processing	[6]
Autophagy-related protein 16-1 (ATG16L1)	OTEOYC5D	A16L1_HUMAN	Gene/Protein Processing	[7]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Gene/Protein Processing	[5]
Beclin-1 (BECN1)	OT4X293M	BECN1_HUMAN	Gene/Protein Processing	[7]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Protein Interaction/Cellular Processes	[5]
Cyclin-dependent kinase 4 (CDK4)	OT7EP05T	CDK4_HUMAN	Gene/Protein Processing	[5]
Cyclin-dependent kinase 6 (CDK6)	OTR95N0X	CDK6_HUMAN	Gene/Protein Processing	[5]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Gene/Protein Processing	[5]

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