Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJPXZ4)

• Drug Name: GSK618334 Drug Info
• Synonyms: Fingolimod hydrochloride; 162359-56-0; FTY720; Fingolimod HCl; Gilenya; Gilenia; Fty-720; Fty 720; Fingolimod (FTY720) HCl; Fingolimod (hydrochloride); 2-Amino-2-(4-octylphenethyl)propane-1,3-diol hydrochloride; 2-Amino-2-(2-(4-octylphenyl)ethyl)-1,3-propanediol hydrochloride; UNII-G926EC510T; Fingolimod hydrochloride [USAN]; CHEBI:63112; G926EC510T; 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride; AK-33554; 2-AMINO-2-[2-(4-OCTYL-PHENYL)-ETHYL]-PROPANE-1,3-DIOL HCL; Fingolimod-d4 Hydrochloride

Indication

Disease Entry	ICD 11	Status	REF
Drug abuse	6C4G.1Z	Phase 1	[1]
Nasopharyngeal carcinoma	2B6B	Investigative	[2]

• Cross-matching ID:
  PubChem CID: 107969
  ChEBI ID: CHEBI:63112
  CAS Number: CAS 162359-56-0
  TTD Drug ID: DMJPXZ4
  INTEDE Drug ID: DR0697

Molecule-Related Drug Atlas

Drug(s) Targeting Dopamine D3 receptor (D3R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cariprazine	DMJYDVK	Bipolar disorder	6A60	Approved	[9]
Pramipexole	DMNMW9R	Parkinson disease	8A00.0	Approved	[10]
Ropinirole	DMA6S1D	Parkinson disease	8A00.0	Approved	[10]
CM-2395	DMASPWR	Schizophrenia	6A20	Phase 3	[11]
P2B-001	DM9PVHX	Parkinson disease	8A00.0	Phase 3	[12]
RP5063	DMKUE8O	Schizophrenia	6A20	Phase 2	[13]
ONC201	DMM5SCF	Endometrial cancer	2C76	Phase 2	[14]
TAK-906	DMBQD9H	Diabetic gastroparesis	DA41.00	Phase 2	[15]
GSK598809	DMGU05N	Drug abuse	6C4G.1Z	Phase 2	[3]
Pfizer 10	DM6ER9L	Female sexual arousal dysfunction	HA01.1	Phase 1	[16]

Drug(s) Targeting Sphingosine kinase 1 (SPHK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phenoxodiol	DMBUJVX	Ovarian cancer	2C73	Phase 1/2	[17]
PMID27539678-Compound-6	DMBKNDE	N. A.	N. A.	Patented	[18]
Methylbenzenesulfonamide derivative 1	DMUNME2	N. A.	N. A.	Patented	[18]
PMID27539678-Compound-12	DMNIKTA	N. A.	N. A.	Patented	[18]
PMID27539678-Compound-10	DM61SR0	N. A.	N. A.	Patented	[18]
PMID27539678-Compound-16	DMMDJH8	N. A.	N. A.	Patented	[18]
PMID27539678-Compound-14	DMZ02LA	N. A.	N. A.	Patented	[18]
PMID27539678-Compound-13	DM1J2V8	N. A.	N. A.	Patented	[18]
PMID27539678-Compound-11	DMIKAJC	N. A.	N. A.	Patented	[18]
PMID27539678-Compound-7	DMQAC4K	N. A.	N. A.	Patented	[18]

Drug(s) Metabolized By Cytochrome P450 4F2 (CYP4F2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[19]
Fingolimod	DM5JVAN	Multiple sclerosis	8A40	Approved	[20]
Ebastine	DMH21D9	N. A.	N. A.	Phase 4	[21]
Pafuramidine	DMFKOR9	Malaria	1F40-1F45	Phase 3	[22]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[23]
Arachidonic Acid	DMUOQZD	Discovery agent	N.A.	Investigative	[24]

Drug(s) Affected By 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[25]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[26]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[27]
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[28]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[29]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[30]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[32]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[33]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[34]

Drug(s) Affected By Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[35]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[36]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[38]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[38]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[33]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]

Drug(s) Affected By Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[32]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[5]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[43]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]

Drug(s) Affected By Squalene monooxygenase (SQLE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[48]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[32]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[49]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]

Drug(s) Affected By Cyclin-G2 (CCNG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[5]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[53]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[54]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[55]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]

Drug(s) Affected By Programmed cell death protein 4 (PDCD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[57]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[58]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[57]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[54]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[60]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[61]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[57]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[62]

Drug(s) Affected By Kelch-like protein 24 (KLHL24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[5]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[54]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[65]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[5]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[66]

Drug(s) Affected By Protein FAM200C (FAM200C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[68]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[5]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[70]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[71]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[72]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[73]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[74]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[75]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[76]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[77]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[78]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[79]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[80]

Drug(s) Affected By Aromatase (CYP19A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[81]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[82]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[83]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[84]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[83]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[85]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[86]
Bifonazole	DM3KN7V	Fungal infection	1F29-1F2F	Approved	[87]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[88]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[83]

Drug(s) Affected By Catechol O-methyltransferase (COMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[89]
Dobutamine	DMD1B8Z	Heart failure	BD10-BD13	Approved	[89]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[89]
Modafinil	DMYILBE	Malignant glioma	2A00.0	Approved	[90]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[89]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[84]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[67]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[93]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[94]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[95]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[96]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[97]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[98]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[99]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Selenium	DM25CGV	N. A.	N. A.	Approved	[101]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[102]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[103]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[104]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[105]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[106]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[107]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[108]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[110]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[111]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[112]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[113]

Drug(s) Affected By C-X-C chemokine receptor type 4 (CXCR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[114]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[115]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[117]
Carfilzomib	DM48K0X	Multiple myeloma	2A83	Approved	[118]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[115]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[120]

Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[72]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[29]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[121]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[122]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[123]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[124]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[125]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[126]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[127]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[128]

Drug(s) Affected By Estrogen receptor beta (ESR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[84]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[129]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[130]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[131]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[132]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[133]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Mestranol	DMG3F94	Contraception	QA21	Approved	[136]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[137]

Drug(s) Affected By NPC intracellular cholesterol transporter 1 (NPC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[138]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[140]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[141]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[142]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]

Drug(s) Affected By Ubiquitin-like protein ATG12 (ATG12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[144]
Selenium	DM25CGV	N. A.	N. A.	Approved	[101]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[145]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[146]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[147]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[148]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[149]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[150]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]

Drug(s) Affected By Ubiquitin-like modifier-activating enzyme ATG7 (ATG7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[151]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[144]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[152]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[153]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[146]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[154]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[155]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[153]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[156]

Drug(s) Affected By Phospholipid-transporting ATPase ABCA1 (ABCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[157]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[158]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[32]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[33]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[159]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[162]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[163]

Drug(s) Affected By T-cell surface glycoprotein CD8 alpha chain (CD8A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[165]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[166]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[167]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[168]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[169]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[170]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[85]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[173]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[107]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[174]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[175]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[176]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[177]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[178]

Drug(s) Affected By T-cell surface glycoprotein CD3 epsilon chain (CD3E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[179]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[167]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[180]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[169]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[181]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[182]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[183]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[184]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[185]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[186]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[185]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[187]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[188]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[189]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[190]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[191]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[192]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[193]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[28]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[181]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[194]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[195]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[196]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[96]

Drug(s) Affected By T-cell-specific surface glycoprotein CD28 (CD28)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[85]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[197]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[198]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[180]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[169]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[36]

Drug(s) Affected By B-lymphocyte antigen CD19 (CD19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[93]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[199]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[53]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[169]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[200]
CATECHIN	DMY38SB	Discovery agent	N.A.	Investigative	[201]

Drug(s) Affected By Transcription factor E3 (TFE3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[165]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[55]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[93]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[55]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[142]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[68]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]

Drug(s) Affected By Sphingosine 1-phosphate receptor 1 (S1PR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[202]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[203]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[142]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[204]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[205]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[206]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[169]

Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[207]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[208]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[151]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[209]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[210]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[211]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[212]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[213]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[214]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[215]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[216]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[217]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[196]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[218]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[219]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[220]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[221]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[222]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[223]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[224]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[216]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[225]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[226]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[227]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[215]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[28]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[228]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[196]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[218]

Drug(s) Affected By CD40 ligand (CD40LG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[229]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[230]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[231]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[232]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[233]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[234]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[235]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[236]
Eptifibatide	DMQXTJS	Acute cardiac ischemic events	BA40.Z	Approved	[237]
Candesartan	DMRK8OT	Chronic heart failure	BD1Z	Approved	[234]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[238]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[239]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[176]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[96]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[240]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[209]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[241]
Selenium	DM25CGV	N. A.	N. A.	Approved	[101]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[30]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[102]

Drug(s) Affected By C-C chemokine receptor type 7 (CCR7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[242]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[140]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[243]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[244]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[243]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[245]

Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[246]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[247]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[208]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[151]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[248]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[102]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[249]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[250]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[251]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[148]

Drug(s) Affected By C-C chemokine receptor type 4 (CCR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[28]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[28]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[252]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[253]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[254]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[169]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[36]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[255]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[256]

Drug(s) Affected By Potassium voltage-gated channel subfamily H member 2 (KCNH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metoclopramide	DMFA5MY	Nausea	MD90	Approved	[257]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[258]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[259]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[260]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[260]
Disopyramide	DM5SYZP	Long QT syndrome	BC65.0	Approved	[261]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[262]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[263]
Dofetilide	DMPN1TW	Sinus rhythm disorder	BC9Y	Approved	[264]
Flecainide	DMSQDLE	Tachyarrhythmias	BC71	Approved	[260]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[247]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[208]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[265]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[266]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[267]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[138]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[268]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[269]

Drug(s) Affected By Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[247]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[153]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[270]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[153]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[271]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[235]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[142]

Drug(s) Affected By Histone deacetylase 1 (HDAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[91]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[272]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[273]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[274]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[275]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[276]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[277]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[142]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[278]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[279]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[280]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[228]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[281]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[282]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[184]
Selenium	DM25CGV	N. A.	N. A.	Approved	[101]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[283]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[85]

Drug(s) Affected By Forkhead box protein P3 (FOXP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[36]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[284]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[33]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[285]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[286]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[93]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[287]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[169]
Dorsomorphin	DMKYXJW	Discovery agent	N.A.	Investigative	[288]
Mepacrine	DMU8L7C	Discovery agent	N.A.	Investigative	[289]

Drug(s) Affected By Autophagy protein 5 (ATG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[290]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[146]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[147]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[291]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[155]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[292]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[56]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[190]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[205]

Drug(s) Affected By Ubiquitin-like-conjugating enzyme ATG3 (ATG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[290]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[293]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[156]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[46]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[47]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[293]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[150]

Drug(s) Affected By Receptor-interacting serine/threonine-protein kinase 3 (RIPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[93]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[271]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[235]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[294]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[70]
Phenylephrine	DMZHUO5	Allergic rhinitis	CA08.0	Approved	[295]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[296]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[169]
OLEIC ACID	DM54O1Z	Discovery agent	N.A.	Investigative	[297]

Drug(s) Affected By Sphingosine kinase 2 (SPHK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[298]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[37]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[85]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[93]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[142]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[299]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[300]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[301]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[302]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Dopamine D3 receptor (D3R)	TT4C8EA	DRD3_HUMAN	Antagonist	[3]
Sphingosine kinase 1 (SPHK1)	TTOHFIY	SPHK1_HUMAN	Inhibitor	[2]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 4F2 (CYP4F2) Main DME	DE3GT9C	CP4F2_HUMAN	Substrate	[4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)	OTRT3F3U	HMDH_HUMAN	Gene/Protein Processing	[5]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[6]
Aromatase (CYP19A1)	OTZ6XF74	CP19A_HUMAN	Gene/Protein Processing	[7]
Autophagy protein 5 (ATG5)	OT4T5SMS	ATG5_HUMAN	Gene/Protein Processing	[8]
B-lymphocyte antigen CD19 (CD19)	OTCPF9NF	CD19_HUMAN	Gene/Protein Processing	[6]
C-C chemokine receptor type 4 (CCR4)	OT68KZ9B	CCR4_HUMAN	Gene/Protein Processing	[6]
C-C chemokine receptor type 7 (CCR7)	OTHFUOYE	CCR7_HUMAN	Gene/Protein Processing	[6]
C-X-C chemokine receptor type 4 (CXCR4)	OTUFSBX2	CXCR4_HUMAN	Gene/Protein Processing	[7]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Gene/Protein Processing	[7]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Protein Interaction/Cellular Processes	[8]

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