Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3G74J)

• Drug Name: Tamibarotene Drug Info
• Synonyms: Tamibarotene (oral, Alzheimer's disease)

Indication

Disease Entry	ICD 11	Status	REF
T-cell leukaemia	2A90	Phase 3	[1]
Alzheimer disease	8A20	Phase 2/3	[2]

• Cross-matching ID:
  PubChem CID: 108143
  ChEBI ID: CHEBI:32181
  CAS Number: CAS 94497-51-5
  TTD Drug ID: DM3G74J

Molecule-Related Drug Atlas

Drug(s) Targeting Retinoic acid receptor beta (RARB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[5]
PMID27336223-Compound-10	DMYUP6G	N. A.	N. A.	Patented	[6]
PMID27336223-Compound-8	DM460D1	N. A.	N. A.	Patented	[6]
PMID27336223-Compound-7	DM9QM6I	N. A.	N. A.	Patented	[6]
CD666	DMC8X9Y	Discovery agent	N.A.	Investigative	[7]
AGN193109	DMC0YOE	Discovery agent	N.A.	Investigative	[8]
AC55649	DM4JNY9	Discovery agent	N.A.	Investigative	[9]
BMS641	DMRT7G3	Discovery agent	N.A.	Investigative	[10]
AC261066	DMSKE1I	Discovery agent	N.A.	Investigative	[9]
TTNPB	DMSABD0	Discovery agent	N.A.	Investigative	[11]

Drug(s) Targeting Retinoic acid receptor alpha (RARA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
IRX-5183	DMCED9U	Solid tumour/cancer	2A00-2F9Z	Phase 1	[12]
SY-1425	DMH8UF0	Acute myeloid leukaemia	2A60	Phase 1	[13]
PMID27336223-Compound-4	DMJFSOM	N. A.	N. A.	Patented	[6]
PMID27336223-Compound-5	DM6E50A	N. A.	N. A.	Patented	[6]
LG100268	DM41RK2	Acquired immune deficiency syndrome	1C62.3	Discontinued in Phase 1	[14]
CD666	DMC8X9Y	Discovery agent	N.A.	Investigative	[7]
AGN193109	DMC0YOE	Discovery agent	N.A.	Investigative	[8]
AGN193836	DMEB93D	Discovery agent	N.A.	Investigative	[15]
BMS614	DMZWNO9	Discovery agent	N.A.	Investigative	[16]
Ro-40-0655	DM8PYAN	Colorectal cancer	2B91.Z	Investigative	[17]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[18]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[19]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[20]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[21]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[21]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[21]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[24]

Drug(s) Affected By Protein-glutamine gamma-glutamyltransferase 2 (TGM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[18]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[25]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[26]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[28]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[31]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[32]

Drug(s) Affected By Golgin subfamily A member 8A (GOLGA8A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[36]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[32]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[37]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[39]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[40]

Drug(s) Affected By TANK-binding kinase 1-binding protein 1 (TBKBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[43]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[44]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[45]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]

Drug(s) Affected By Alternative prion protein (PRNP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[48]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[52]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[53]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[53]

Drug(s) Affected By Alkyldihydroxyacetonephosphate synthase, peroxisomal (AGPS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[56]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[60]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[61]

Drug(s) Affected By Kinesin-like protein KIF2A (KIF2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[63]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[64]

Drug(s) Affected By Galectin-9 (LGALS9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[66]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[69]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PIK3CD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[70]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[73]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[74]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[75]

Drug(s) Affected By Pyruvate dehydrogenase protein X component, mitochondrial (PDHX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[78]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[79]

Drug(s) Affected By Importin-5 (IPO5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Indomethacin	DMSC4A7	Bursitis		Approved	[83]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]

Drug(s) Affected By Serine/threonine-protein kinase PLK4 (PLK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[85]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[86]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[87]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[88]

Drug(s) Affected By Leukocyte-specific transcript 1 protein (LST1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Bortezomib	DMNO38U	Leukemia		Approved	[90]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[91]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Coprexa	DMA0WEK	Neurological disorder	6B60	Phase 3	[92]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[93]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[94]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[80]

Drug(s) Affected By Stearoyl-CoA desaturase (SCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[95]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[96]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[96]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[97]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[96]
Fructose	DM43AN2	Vomiting	MD90	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[96]

Drug(s) Affected By Class E basic helix-loop-helix protein 40 (BHLHE40)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[99]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[102]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]

Drug(s) Affected By Aquaporin-7 (AQP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[105]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[106]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[107]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[108]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[109]

Drug(s) Affected By Nuclear envelope integral membrane protein 1 (NEMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[90]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[86]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[110]

Drug(s) Affected By Thymosin beta-4, Y-chromosomal (TMSB4Y)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[44]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[112]

Drug(s) Affected By Segment polarity protein dishevelled homolog DVL-1 (DVL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[113]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[114]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[115]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[63]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[116]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[117]

Drug(s) Affected By Torsin-1B (TOR1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[110]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[44]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[120]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[121]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[109]

Drug(s) Affected By Syntaxin-16 (STX16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[90]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[110]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]

Drug(s) Affected By Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[123]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]

Drug(s) Affected By Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[125]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[124]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[126]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[118]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[127]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[128]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]

Drug(s) Affected By Antizyme inhibitor 1 (AZIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[129]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[73]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[43]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[63]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[73]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[130]

Drug(s) Affected By Protein transport protein Sec16A (SEC16A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]

Drug(s) Affected By FYN-binding protein 1 (FYB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[132]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[134]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[106]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[135]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By Secretory carrier-associated membrane protein 1 (SCAMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[21]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]

Drug(s) Affected By Phospholipid scramblase 1 (PLSCR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[18]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]

Drug(s) Affected By Axin-1 (AXIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[43]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[63]
Daporinad	DMCU74R	leukaemia	2A60-2B33	Phase 2	[138]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[139]

Drug(s) Affected By UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Bortezomib	DMNO38U	Leukemia		Approved	[90]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[62]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[88]

Drug(s) Affected By Monocarboxylate transporter 4 (SLC16A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[141]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[142]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]

Drug(s) Affected By Regulator of G-protein signaling 16 (RGS16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[144]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[143]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[147]

Drug(s) Affected By N-glycosylase/DNA lyase (OGG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[148]
Selenium	DM25CGV	N. A.	N. A.	Approved	[149]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[150]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[151]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[152]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[153]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[154]

Drug(s) Affected By mRNA cap guanine-N7 methyltransferase (RNMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Lithium	DMZ3OU6	Bipolar disorder	6A60	Phase 2	[155]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[61]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]

Drug(s) Affected By Cytoplasmic dynein 1 light intermediate chain 2 (DYNC1LI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[158]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[159]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[62]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[160]

Drug(s) Affected By CBP80/20-dependent translation initiation factor (CTIF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[161]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[39]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[162]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[80]

Drug(s) Affected By Eukaryotic translation elongation factor 1 epsilon-1 (EEF1E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[163]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[88]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[164]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[39]

Drug(s) Affected By RNA-binding protein Musashi homolog 1 (MSI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[145]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[165]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[166]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[167]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[135]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
SB-431542	DM0YOXQ	Pulmonary fibrosis	CB03.4	Preclinical	[168]

Drug(s) Affected By Trans-Golgi network integral membrane protein 2 (TGOLN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[158]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[158]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[158]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[169]

Drug(s) Affected By Protein-glutamine gamma-glutamyltransferase 5 (TGM5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[44]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[170]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[45]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[33]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[109]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 14 (TNFSF14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[174]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[106]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[44]
PF-3758309	DM36PKZ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[175]

Drug(s) Affected By Protein sprouty homolog 2 (SPRY2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[48]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[86]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]

Drug(s) Affected By Glutamyl-tRNA(Gln) amidotransferase subunit C, mitochondrial (GATC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[129]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[110]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[109]

Drug(s) Affected By Cleavage and polyadenylation specificity factor subunit 5 (NUDT21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[88]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[177]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]

Drug(s) Affected By Cyclic AMP-responsive element-binding protein 3 (CREB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[118]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[129]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]

Drug(s) Affected By Docking protein 2 (DOK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[93]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[80]

Drug(s) Affected By Protein O-GlcNAcase (OGA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[178]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[179]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[44]

Drug(s) Affected By Exocyst complex component 3 (EXOC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[180]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[157]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[121]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[82]

Drug(s) Affected By Monocarboxylate transporter 2 (SLC16A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[127]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[181]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[182]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]

Drug(s) Affected By DNA polymerase zeta catalytic subunit (REV3L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[183]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[184]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[147]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[73]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[73]

Drug(s) Affected By Coiled-coil domain-containing protein 22 (CCDC22)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[185]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[186]

Drug(s) Affected By Ankyrin repeat domain-containing protein 17 (ANKRD17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[134]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[43]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[187]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[157]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[157]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[80]

Drug(s) Affected By Pre-mRNA-processing factor 40 homolog A (PRPF40A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[188]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[71]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[61]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[157]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[157]

Drug(s) Affected By Histone deacetylase complex subunit SAP30 (SAP30)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[189]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[190]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[88]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[191]

Drug(s) Affected By Serine/arginine-rich splicing factor 10 (SRSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[163]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[88]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[192]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[193]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[61]

Drug(s) Affected By Protein CREG1 (CREG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[39]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[40]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[40]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[194]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[39]

Drug(s) Affected By U5 small nuclear ribonucleoprotein 200 kDa helicase (SNRNP200)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[118]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[159]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[159]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[62]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[61]

Drug(s) Affected By Short-chain dehydrogenase/reductase 3 (DHRS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[102]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[32]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]

Drug(s) Affected By Flotillin-1 (FLOT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[195]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[106]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[114]

Drug(s) Affected By Triple functional domain protein (TRIO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[196]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Bortezomib	DMNO38U	Leukemia		Approved	[90]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]

Drug(s) Affected By Protein transport protein Sec31A (SEC31A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[159]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[134]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]

Drug(s) Affected By Calmodulin-binding transcription activator 2 (CAMTA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[91]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[181]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By Amyloid-beta A4 precursor protein-binding family B member 3 (APBB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[186]

Drug(s) Affected By Adenosine deaminase (ADA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[197]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[32]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Corticotropin	DMP9TWZ	Cushing disease	5A70	Approved	[198]

Drug(s) Affected By 2'-5'-oligoadenylate synthase 1 (OAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[199]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[124]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[200]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]

Drug(s) Affected By Metalloproteinase inhibitor 1 (TIMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pentoxifylline	DMU3DNC	Alcoholic hepatitis	DB94.1	Approved	[201]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[202]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[203]
Selenium	DM25CGV	N. A.	N. A.	Approved	[204]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[203]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[205]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[206]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[207]

Drug(s) Affected By Cystatin-C (CST3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[209]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[180]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[210]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[211]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[212]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[213]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[65]
Selenium	DM25CGV	N. A.	N. A.	Approved	[214]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[215]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[216]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[217]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[218]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[219]
Fructose	DM43AN2	Vomiting	MD90	Approved	[201]
Ketoprofen	DMRKXPT	Bursitis		Approved	[201]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[220]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[221]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[222]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[223]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[224]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[225]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[226]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[227]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[228]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[229]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[230]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[229]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[231]
Selenium	DM25CGV	N. A.	N. A.	Approved	[232]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[233]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[234]

Drug(s) Affected By Tissue alpha-L-fucosidase (FUCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[36]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]

Drug(s) Affected By Metallothionein-1A (MT1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[235]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[236]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[237]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[238]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[209]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[236]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[236]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[184]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]

Drug(s) Affected By Cytochrome b-245 heavy chain (CYBB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[239]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[240]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[107]
Dalcetrapib	DMKNCVM	Acute coronary syndrome	BA41	Phase 3	[241]
Anacetrapib	DMP2BFG	Arteriosclerosis	BD40	Phase 3	[241]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[242]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By Protein S100-A8 (S100A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[243]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[244]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[243]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[173]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[178]
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[243]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[243]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]

Drug(s) Affected By Plasminogen activator inhibitor 2 (SERPINB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[246]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[227]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[247]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[248]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]

Drug(s) Affected By Ubiquitin-like protein ISG15 (ISG15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[249]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[124]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[250]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[251]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[127]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[128]

Drug(s) Affected By Endothelin-1 (EDN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[252]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[253]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[255]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[256]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[257]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[258]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[259]

Drug(s) Affected By Protein kinase C beta type (PRKCB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[260]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[261]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[262]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[260]

Drug(s) Affected By Tyrosine-protein kinase Lck (LCK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[263]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[264]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[265]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[191]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[266]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[267]

Drug(s) Affected By Tyrosine-protein kinase Fyn (FYN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[268]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[269]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[270]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[100]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[271]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[272]

Drug(s) Affected By Gelsolin (GSN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[273]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]

Drug(s) Affected By Protein S100-A9 (S100A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[243]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[244]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[274]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[178]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[275]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]

Drug(s) Affected By Glutathione peroxidase 1 (GPX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[276]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Amlexanox	DM0DQM5	Respiratory tract inflammation	CA07	Approved	[277]
Selenium	DM25CGV	N. A.	N. A.	Approved	[278]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[279]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[280]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[281]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[249]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[282]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[283]

Drug(s) Affected By Tyrosine-protein kinase Fes/Fps (FES)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[44]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[157]

Drug(s) Affected By Cathepsin D (CTSD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[284]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[285]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[286]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[287]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[288]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]

Drug(s) Affected By Annexin A2 (ANXA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[289]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[290]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[291]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[292]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[293]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[294]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[295]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]

Drug(s) Affected By Galactose-1-phosphate uridylyltransferase (GALT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[100]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[296]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[296]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[44]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[297]

Drug(s) Affected By Tyrosine-protein kinase Lyn (LYN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[298]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[264]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[299]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]

Drug(s) Affected By Heat shock protein HSP 90-beta (HSP90AB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[300]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[301]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[302]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[303]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[281]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[304]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]

Drug(s) Affected By Extracellular superoxide dismutase (SOD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[305]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[306]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[145]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[307]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[308]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[309]

Drug(s) Affected By Pleckstrin (PLEK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[90]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[310]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[106]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[311]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[162]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[121]
5'-Guanosine-Diphosphate-Monothiophosphate	DMIARG7	Discovery agent	N.A.	Investigative	[311]

Drug(s) Affected By Tyrosine-protein kinase HCK (HCK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[264]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[145]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[268]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[312]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[43]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[313]

Drug(s) Affected By Galectin-1 (LGALS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[19]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[249]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[269]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[178]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[314]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[295]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[315]

Drug(s) Affected By Fructose-1,6-bisphosphatase 1 (FBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[316]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[173]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[145]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[317]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[318]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[319]

Drug(s) Affected By Glutathione S-transferase Mu 1 (GSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[320]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[321]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[40]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[322]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[245]
Methyldopa	DM5I621	Hypertension	BA00-BA04	Approved	[323]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]

Drug(s) Affected By Clathrin light chain B (CLTB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[324]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[325]

Drug(s) Affected By Tyrosine-protein kinase Fgr (FGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[264]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[178]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[21]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[268]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[326]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[106]

Drug(s) Affected By Adenosine receptor A3 (ADORA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[328]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[329]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Indomethacin	DMSC4A7	Bursitis		Approved	[330]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[190]

Drug(s) Affected By Choriogonadotropin subunit beta 3 (CGB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[331]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[332]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[333]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[310]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[333]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Bezafibrate	DMZDCS0	Hypercholesterolaemia	5C80.0	Approved	[334]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[335]

Drug(s) Affected By Transcriptional activator Myb (MYB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[336]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[337]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[338]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[299]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[336]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[339]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[340]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]

Drug(s) Affected By HLA class I histocompatibility antigen, C alpha chain (HLA-C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[341]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[342]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[343]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[106]
Ticlopidine	DMO946V	Acute coronary syndrome	BA41	Approved	[344]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[48]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]

Drug(s) Affected By Osteopontin (SPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[345]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[19]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[346]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[347]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[348]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[349]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[102]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[350]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase F (PTPRF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[329]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]

Drug(s) Affected By Interferon regulatory factor 1 (IRF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[264]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[178]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[129]

Drug(s) Affected By Laminin subunit gamma-1 (LAMC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[351]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Indomethacin	DMSC4A7	Bursitis		Approved	[352]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[62]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[88]

Drug(s) Affected By Integrin alpha-M (ITGAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[353]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[354]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[355]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[356]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[357]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[358]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[359]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[360]

Drug(s) Affected By Serine/threonine-protein kinase pim-1 (PIM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[227]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[361]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[126]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[340]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]

Drug(s) Affected By Fibroblast growth factor receptor 1 (FGFR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[48]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[362]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[362]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]

Drug(s) Affected By DNA topoisomerase 1 (TOP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Teniposide	DMLW57T	Acute lymphoblastic leukaemia	2A85	Approved	[201]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[301]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[363]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[21]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]

Drug(s) Affected By DNA topoisomerase 2-alpha (TOP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[364]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[365]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[366]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[367]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[99]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[363]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[368]

Drug(s) Affected By Eosinophil peroxidase (EPX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[369]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[106]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[370]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[371]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
Butanoic Acid	DMTAJP7	Discovery agent	N.A.	Investigative	[372]

Drug(s) Affected By Ornithine decarboxylase (ODC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[246]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[373]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[374]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[375]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[245]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[200]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[178]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[376]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[377]

Drug(s) Affected By Proliferating cell nuclear antigen (PCNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[246]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[212]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Selenium	DM25CGV	N. A.	N. A.	Approved	[214]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[378]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[379]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[380]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[244]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[381]

Drug(s) Affected By Nucleoprotein TPR (TPR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[289]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[382]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[159]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[159]

Drug(s) Affected By High affinity immunoglobulin gamma Fc receptor I (FCGR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[190]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
Maleic Acid	DM4L0R7	Discovery agent	N.A.	Investigative	[384]
Rapamycin Immunosuppressant Drug	DM678IB	Discovery agent	N.A.	Investigative	[383]
PHENCYCLIDINE	DMQBEYX	Discovery agent	N.A.	Investigative	[385]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[386]

Drug(s) Affected By 5-aminolevulinate synthase, non-specific, mitochondrial (ALAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[387]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[388]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[317]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[100]

Drug(s) Affected By C-C motif chemokine 4 (CCL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[281]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[389]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[390]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[178]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[391]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[391]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]

Drug(s) Affected By Cytochrome b-245 light chain (CYBA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[392]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[393]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[394]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[369]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]

Drug(s) Affected By C-C motif chemokine 5 (CCL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[366]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[395]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[396]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[397]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[398]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[390]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[399]

Drug(s) Affected By Integrin alpha-4 (ITGA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[245]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[400]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[401]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[402]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[245]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[403]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[106]

Drug(s) Affected By Sodium/potassium-transporting ATPase subunit alpha-3 (ATP1A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[404]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Bortezomib	DMNO38U	Leukemia		Approved	[90]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[116]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[44]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[405]

Drug(s) Affected By HLA class I histocompatibility antigen, alpha chain E (HLA-E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[406]
Clindamycin	DM15HL8	Acne vulgaris	ED80	Approved	[406]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[406]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[406]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[173]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[406]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]

Drug(s) Affected By Collagen alpha-2(XI) chain (COL11A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[407]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[107]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[40]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[39]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[80]

Drug(s) Affected By L-selectin (SELL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[408]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[408]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[409]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[408]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[410]
Nabumetone	DMAT2XH	Osteoarthritis	FA00-FA05	Approved	[408]
Phenylbutazone	DMAYL0T	Chronic pain	MG30	Approved	[408]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]

Drug(s) Affected By Neutrophil cytosol factor 1 (NCF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[411]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[369]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[412]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[413]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[414]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[415]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[416]

Drug(s) Affected By Endoplasmin (HSP90B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[300]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[301]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[290]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[417]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[28]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[127]

Drug(s) Affected By 15-hydroxyprostaglandin dehydrogenase (HPGD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[97]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[298]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[173]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[418]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[418]

Drug(s) Affected By Small ribosomal subunit protein uS5 (RPS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[419]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[61]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[157]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[420]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[109]

Drug(s) Affected By Aggrecan core protein (ACAN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[421]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[86]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[422]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[423]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[424]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[107]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[425]
Diacerein	DMN2Q5I	N. A.	N. A.	Phase 4	[426]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By Cyclic AMP-responsive element-binding protein 1 (CREB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[427]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[428]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[196]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[429]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[430]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[431]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[431]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[432]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[433]

Drug(s) Affected By SH2/SH3 adapter protein NCK1 (NCK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[434]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[435]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[88]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[63]

Drug(s) Affected By Histone H1.3 (H1-3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[436]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[437]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[438]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[439]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[440]

Drug(s) Affected By NADPH--cytochrome P450 reductase (POR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Tacrolimus	DMZ7XNQ	Graft-versus-host disease	4B24	Approved	[441]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[442]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[281]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[264]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]

Drug(s) Affected By Rho-related GTP-binding protein RhoQ (RHOQ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[184]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[73]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[164]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[110]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[73]

Drug(s) Affected By Bactericidal permeability-increasing protein (BPI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[269]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By Sphingomyelin phosphodiesterase (SMPD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[348]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[443]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[444]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]

Drug(s) Affected By CCAAT/enhancer-binding protein beta (CEBPB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[246]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[445]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[446]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[447]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[448]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]

Drug(s) Affected By HLA class I histocompatibility antigen, alpha chain G (HLA-G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[406]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[406]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[406]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[406]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[406]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[406]

Drug(s) Affected By S-adenosylmethionine decarboxylase proenzyme (AMD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[118]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Indomethacin	DMSC4A7	Bursitis		Approved	[83]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[449]

Drug(s) Affected By Insulin-like growth factor-binding protein 2 (IGFBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[450]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[369]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[451]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]

Drug(s) Affected By Protein SON (SON)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[301]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[21]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[21]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]

Drug(s) Affected By Regulator of chromosome condensation (RCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[452]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[453]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[454]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[61]

Drug(s) Affected By Leukocyte surface antigen CD53 (CD53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[178]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[127]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[403]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[107]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By Glutathione hydrolase 1 proenzyme (GGT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[201]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[134]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[91]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[194]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[201]

Drug(s) Affected By Plasma membrane calcium-transporting ATPase 1 (ATP2B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[351]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[32]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[147]

Drug(s) Affected By Serine protease inhibitor Kazal-type 2 (SPINK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[455]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[129]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[49]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[49]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[35]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[456]

Drug(s) Affected By Azurocidin (AZU1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[457]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[110]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[267]
PF-3758309	DM36PKZ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[175]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[458]
Tributylstannanyl	DMHN7CB	Discovery agent	N.A.	Investigative	[458]

Drug(s) Affected By B-cell receptor CD22 (CD22)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[298]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[43]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[44]
Bryostatin-1	DM1JOXY	Alzheimer disease	8A20	Phase 2	[459]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[460]

Drug(s) Affected By Transcription factor BTF3 (BTF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[461]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[93]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[461]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[157]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[64]

Drug(s) Affected By Arachidonate 5-lipoxygenase-activating protein (ALOX5AP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[65]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[462]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[269]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[173]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[90]
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[463]

Drug(s) Affected By Ras-related protein Rab-4A (RAB4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Tacrolimus	DMZ7XNQ	Graft-versus-host disease	4B24	Approved	[464]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[191]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[157]

Drug(s) Affected By Ras-related protein Rab-5A (RAB5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Bortezomib	DMNO38U	Leukemia		Approved	[90]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[63]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[191]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[44]

Drug(s) Affected By Ras-related protein Rab-6A (RAB6A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Risedronate	DM5FLTY	Bone Paget disease		Approved	[465]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[90]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[110]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[39]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[466]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[419]

Drug(s) Affected By Interferon-induced GTP-binding protein Mx2 (MX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[269]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[127]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[128]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[184]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[434]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[190]

Drug(s) Affected By Lamin-B1 (LMNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[467]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[99]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[445]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[468]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[245]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]

Drug(s) Affected By Endothelin-2 (EDN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[126]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[469]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[123]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[470]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[471]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]

Drug(s) Affected By Cysteine and glycine-rich protein 1 (CSRP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[472]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[315]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]

Drug(s) Affected By Diamine acetyltransferase 1 (SAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[473]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[99]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[474]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[474]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]

Drug(s) Affected By Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[475]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Haloperidol	DM96SE0	Delirium		Approved	[159]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[159]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[475]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Lithium	DMZ3OU6	Bipolar disorder	6A60	Phase 2	[155]

Drug(s) Affected By Alpha-(1,3)-fucosyltransferase 4 (FUT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[476]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[43]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[477]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[44]

Drug(s) Affected By Small proline-rich protein 2D (SPRR2D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[246]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[106]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[478]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By cAMP-dependent protein kinase catalytic subunit beta (PRKACB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[304]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[304]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[90]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[123]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[73]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[479]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[480]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[126]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[310]
Mirtazapine	DML53ZJ	Depression	6A70-6A7Z	Approved	[481]
Methamphetamine	DMPM4SK	Anxiety		Approved	[482]

Drug(s) Affected By Splicing factor, proline- and glutamine-rich (SFPQ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[301]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[315]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[159]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]

Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[483]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[484]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[485]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[486]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[216]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[487]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[488]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[489]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[490]

Drug(s) Affected By Tyrosine-protein kinase JAK1 (JAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[196]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[491]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[492]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[493]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]

Drug(s) Affected By Eukaryotic translation initiation factor 4B (EIF4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[494]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[495]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[496]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[62]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[497]

Drug(s) Affected By Endothelial transcription factor GATA-2 (GATA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[498]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[499]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[46]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[500]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[501]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[502]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[503]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[504]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[505]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[361]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[215]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[506]

Drug(s) Affected By COUP transcription factor 2 (NR2F2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[507]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[144]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[211]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[508]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[276]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[509]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[510]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[250]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[511]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[512]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[513]

Drug(s) Affected By Adenomatous polyposis coli protein (APC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[48]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[514]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[118]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[183]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[129]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[515]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[174]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[163]

Drug(s) Affected By Nuclear transcription factor Y subunit beta (NFYB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[516]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[461]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[63]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[461]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]

Drug(s) Affected By Metallothionein-3 (MT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[305]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[237]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[517]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[184]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[518]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[519]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[520]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[107]

Drug(s) Affected By Integrin beta-7 (ITGB7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[326]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[93]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[162]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[82]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[521]
STO609	DMZSOG2	Discovery agent	N.A.	Investigative	[522]

Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 3 (PTPN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[132]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[24]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[329]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]

Drug(s) Affected By Adenylate kinase 4, mitochondrial (AK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[523]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[298]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[21]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[21]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[448]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[401]

Drug(s) Affected By Proteasome subunit beta type-9 (PSMB9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[524]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[525]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[526]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[527]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[507]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[524]

Drug(s) Affected By Grancalcin (GCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[507]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[39]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[63]

Drug(s) Affected By Progranulin (GRN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[528]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[62]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[88]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[110]

Drug(s) Affected By ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[529]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[530]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[531]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[532]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[533]
Bortezomib	DMNO38U	Leukemia		Approved	[90]
Omacetaxine mepesuccinate	DMPU2WX	Adult acute monocytic leukemia		Approved	[530]
Novobiocin	DMRFWGK	Bacterial infection	1A00-1C4Z	Approved	[534]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]

Drug(s) Affected By 2'-5'-oligoadenylate synthase 2 (OAS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[535]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[127]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[128]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[536]
Amantadine	DMS3YE9	Influenza A virus infection	1E30	Approved	[537]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[538]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PPP2R1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[73]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[88]

Drug(s) Affected By High affinity immunoglobulin epsilon receptor subunit gamma (FCER1G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[264]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[145]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[91]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[539]

Drug(s) Affected By M-phase inducer phosphatase 1 (CDC25A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[540]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[48]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[143]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[541]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[542]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[543]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[544]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[545]

Drug(s) Affected By Leukocyte elastase inhibitor (SERPINB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[302]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[546]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[200]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[547]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]

Drug(s) Affected By Aldehyde dehydrogenase X, mitochondrial (ALDH1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[548]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[145]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]

Drug(s) Affected By Coronin-1A (CORO1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[549]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[251]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[145]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[550]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[551]

Drug(s) Affected By S-adenosylmethionine synthase isoform type-2 (MAT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[159]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[552]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[553]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[552]

Drug(s) Affected By Ribonucleoside-diphosphate reductase subunit M2 (RRM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[554]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[540]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[99]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[85]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]

Drug(s) Affected By Low affinity immunoglobulin gamma Fc region receptor II-b (FCGR2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[555]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[539]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[130]
cinnamaldehyde	DMZDUXG	Discovery agent	N.A.	Investigative	[556]

Drug(s) Affected By C-C chemokine receptor type 1 (CCR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[48]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[434]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[557]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[558]

Drug(s) Affected By C-X-C chemokine receptor type 5 (CXCR5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[557]
MLN4924	DMP36KD	Myelodysplastic syndrome	2A37	Phase 3	[559]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[162]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[521]

Drug(s) Affected By 4-hydroxyphenylpyruvate dioxygenase (HPD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[110]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[37]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[297]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[157]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[560]

Drug(s) Affected By Intercellular adhesion molecule 3 (ICAM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[269]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[264]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[561]

Drug(s) Affected By Lymphocyte-specific protein 1 (LSP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[299]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[562]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[184]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]

Drug(s) Affected By Fibrillin-2 (FBN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[101]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[184]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[110]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[161]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[107]

Drug(s) Affected By Glutaredoxin-1 (GLRX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[563]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[507]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[163]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]

Drug(s) Affected By Choline kinase alpha (CHKA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]

Drug(s) Affected By Serine/threonine-protein kinase receptor R3 (ACVRL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[564]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[184]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[39]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[565]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[566]

Drug(s) Affected By Breast cancer type 1 susceptibility protein (BRCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[246]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[503]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[567]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[568]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[511]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[569]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]

Drug(s) Affected By V-type proton ATPase catalytic subunit A (ATP6V1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[570]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[159]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]

Drug(s) Affected By Macrophage-capping protein (CAPG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[302]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[548]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[145]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]

Drug(s) Affected By Replication factor C subunit 5 (RFC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[540]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[244]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[571]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[159]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[86]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[152]

Drug(s) Affected By Cyclin-F (CCNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[246]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[337]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[572]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[436]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]

Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 3 (EIF2S3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[159]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[159]
Bortezomib	DMNO38U	Leukemia		Approved	[90]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[61]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[94]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[82]

Drug(s) Affected By Protein kinase C iota type (PRKCI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[573]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[73]
Indomethacin	DMSC4A7	Bursitis		Approved	[83]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[73]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[40]

Drug(s) Affected By Enoyl-CoA delta isomerase 1, mitochondrial (ECI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]

Drug(s) Affected By Lamina-associated polypeptide 2, isoform alpha (TMPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[301]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[563]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[85]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]

Drug(s) Affected By Signal transducer and activator of transcription 1-alpha/beta (STAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[301]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[574]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[124]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[445]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[575]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[511]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[576]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[124]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]

Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PIK3CB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[577]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[578]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[201]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[579]

Drug(s) Affected By Translocon-associated protein subunit alpha (SSR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[580]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]

Drug(s) Affected By Transcriptional regulator ATRX (ATRX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[196]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[581]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[127]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[183]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[24]

Drug(s) Affected By Radiation-inducible immediate-early gene IEX-1 (IER3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[246]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[48]
Selenium	DM25CGV	N. A.	N. A.	Approved	[232]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[448]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[126]

Drug(s) Affected By Serpin B10 (SERPINB10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[582]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[80]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[583]

Drug(s) Affected By Excitatory amino acid transporter 4 (SLC1A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[298]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[584]
Indomethacin	DMSC4A7	Bursitis		Approved	[585]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[109]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[35]

Drug(s) Affected By Phosphatidylinositol transfer protein beta isoform (PITPNB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[159]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[586]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[43]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]

Drug(s) Affected By Cyclin-dependent kinase 8 (CDK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[337]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[587]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[116]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[44]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[588]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[589]
Tanespimycin	DMNLQHK	Breast cancer	2C60-2C65	Phase 2	[590]

Drug(s) Affected By Glutamate dehydrogenase 2, mitochondrial (GLUD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[290]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[129]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[191]

Drug(s) Affected By Homeobox even-skipped homolog protein 1 (EVX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[36]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By CCAAT/enhancer-binding protein delta (CEBPD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[85]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[178]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]

Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[300]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[591]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[592]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[593]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[594]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[514]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[595]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[596]

Drug(s) Affected By Guanine nucleotide-binding protein G(q) subunit alpha (GNAQ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[73]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[73]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[216]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[201]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[191]

Drug(s) Affected By Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4 (GNG4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[597]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[73]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[73]

Drug(s) Affected By Sulfate transporter (SLC26A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[301]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[141]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[598]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[62]

Drug(s) Affected By Serpin B8 (SERPINB8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[245]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[118]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[245]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[599]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[18]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[600]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[601]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[602]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[281]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[576]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[102]

Drug(s) Affected By Lipopolysaccharide-responsive and beige-like anchor protein (LRBA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[603]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[604]

Drug(s) Affected By Poly(A) polymerase alpha (PAPOLA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Bortezomib	DMNO38U	Leukemia		Approved	[90]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[605]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By Ras-related protein Rab-5C (RAB5C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[606]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[62]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[419]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[419]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[607]

Drug(s) Affected By Breast cancer type 2 susceptibility protein (BRCA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[608]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[511]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[609]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[118]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]

Drug(s) Affected By Signal transducer and activator of transcription 5B (STAT5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[574]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[610]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[264]
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[611]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[612]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[613]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[73]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[614]

Drug(s) Affected By Chloride channel protein ClC-Ka (CLCNKA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[296]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[296]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By Ribosomal protein S6 kinase alpha-3 (RPS6KA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[211]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[615]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[437]

Drug(s) Affected By Cyclin-G1 (CCNG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[281]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[174]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[616]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[62]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[471]

Drug(s) Affected By 6-phosphogluconate dehydrogenase, decarboxylating (PGD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[307]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Methylene blue	DMJAPE7	Acquired methemoglobinemia	3A93	Approved	[617]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[307]

Drug(s) Affected By Nuclear cap-binding protein subunit 2 (NCBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[163]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[272]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[110]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[420]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[49]

Drug(s) Affected By DNA mismatch repair protein Msh6 (MSH6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[540]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]

Drug(s) Affected By Hexokinase-3 (HK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[173]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[562]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[43]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[93]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[618]

Drug(s) Affected By Protein FosB (FOSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[144]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[264]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[619]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[118]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[620]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[621]

Drug(s) Affected By CCAAT/enhancer-binding protein gamma (CEBPG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[118]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[129]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[622]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[88]

Drug(s) Affected By Geranylgeranyl transferase type-2 subunit beta (RABGGTB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[63]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[91]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[44]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[623]

Drug(s) Affected By E3 ubiquitin-protein ligase TTC3 (TTC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[196]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[382]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[296]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[296]

Drug(s) Affected By Monocarboxylate transporter 1 (SLC16A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[141]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[245]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[304]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[509]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[624]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]

Drug(s) Affected By Protein HIRA (HIRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[158]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[329]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[625]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[39]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[626]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[157]

Drug(s) Affected By Branched-chain-amino-acid aminotransferase, cytosolic (BCAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[289]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[21]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[21]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[21]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]

Drug(s) Affected By Allograft inflammatory factor 1 (AIF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[173]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[174]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[627]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[39]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[628]

Drug(s) Affected By Bax inhibitor 1 (TMBIM6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[629]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[82]

Drug(s) Affected By Microfibril-associated glycoprotein 3 (MFAP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[44]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[109]

Drug(s) Affected By Nucleosome assembly protein 1-like 1 (NAP1L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[289]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[546]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[570]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[561]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[630]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[631]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[246]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[632]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[633]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[634]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[635]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[636]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[637]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[638]

Drug(s) Affected By Protein arginine N-methyltransferase 2 (PRMT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[639]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[43]

Drug(s) Affected By AP-1 complex subunit sigma-2 (AP1S2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[640]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[298]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[310]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[91]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]

Drug(s) Affected By ADP-ribosylation factor-like protein 4C (ARL4C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[401]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Bortezomib	DMNO38U	Leukemia		Approved	[90]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[134]

Drug(s) Affected By Ribose-phosphate pyrophosphokinase 1 (PRPS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[21]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[88]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[164]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[106]

Drug(s) Affected By NPC intracellular cholesterol transporter 2 (NPC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[641]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[296]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[296]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[44]
Isoflavone	DM7U58J	N. A.	N. A.	Phase 4	[642]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[643]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[644]

Drug(s) Affected By Nuclear transport factor 2 (NUTF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[71]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[94]

Drug(s) Affected By Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PPP1CB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[70]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[351]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[288]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]

Drug(s) Affected By ADP-ribosylation factor 6 (ARF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[645]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[163]
Bortezomib	DMNO38U	Leukemia		Approved	[90]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[415]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[43]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]

Drug(s) Affected By Histone H4 (H4C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[246]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[563]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[509]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[646]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[548]

Drug(s) Affected By Ras-related protein Rab-1A (RAB1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[88]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[647]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[40]

Drug(s) Affected By Elongation factor 1-alpha 1 (EEF1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[302]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[298]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[101]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[200]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[299]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[648]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[315]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[174]

Drug(s) Affected By Glutathione S-transferase omega-1 (GSTO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[200]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[174]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[649]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[650]

Drug(s) Affected By DNA-dependent protein kinase catalytic subunit (PRKDC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[301]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[348]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[304]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[651]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[118]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[652]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]

Drug(s) Affected By Protein BTG2 (BTG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[563]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[653]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[654]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[436]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[178]

Drug(s) Affected By Interferon-induced 35 kDa protein (IFI35)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[124]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[128]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]

Drug(s) Affected By Serine/arginine-rich splicing factor 3 (SRSF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[88]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[644]

Drug(s) Affected By Rho GTPase-activating protein 4 (ARHGAP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[655]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[145]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[329]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[93]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By Forkhead box protein O4 (FOXO4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[562]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[526]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[656]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[296]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[43]

Drug(s) Affected By Interferon regulatory factor 9 (IRF9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[264]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[127]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[128]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]

Drug(s) Affected By Runt-related transcription factor 1 (RUNX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[21]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[21]
Cotinine	DMCEZ1B	Insecticide	N.A.	Approved	[657]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]

Drug(s) Affected By N-acetylgalactosamine kinase (GALK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[110]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[658]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[78]

Drug(s) Affected By Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[159]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[96]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[96]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[523]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[96]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]

Drug(s) Affected By Transgelin (TAGLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[659]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[450]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[660]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[659]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[401]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[659]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[659]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[661]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[660]

Drug(s) Affected By DNA topoisomerase 2-beta (TOP2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[365]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[301]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[174]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[662]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[62]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[663]

Drug(s) Affected By Dystonin (DST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[548]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[183]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[36]

Drug(s) Affected By Tumor necrosis factor alpha-induced protein 2 (TNFAIP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[124]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[126]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]

Drug(s) Affected By Antigen peptide transporter 1 (TAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[250]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[250]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]

Drug(s) Affected By Antigen peptide transporter 2 (TAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[664]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[163]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[665]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[319]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[226]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[502]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[568]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[666]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[262]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[667]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[668]

Drug(s) Affected By Protein kinase C delta type (PRKCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[304]
Butorphanol	DM5KYPJ	Pain	MG30-MG3Z	Approved	[669]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[670]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[671]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[672]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[118]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[129]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[673]

Drug(s) Affected By Amidophosphoribosyltransferase (PPAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[548]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[268]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[403]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[164]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[106]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[43]

Drug(s) Affected By Glutamine--fructose-6-phosphate aminotransferase 1 (GFPT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-glutamine	DM69G8X	Short bowel syndrome	KB89.1	Approved	[201]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[201]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[126]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[118]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]

Drug(s) Affected By Early growth response protein 3 (EGR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[336]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[674]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[85]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[126]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[118]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]

Drug(s) Affected By Early activation antigen CD69 (CD69)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[448]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[664]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[448]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[448]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[675]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[532]

Drug(s) Affected By Protocadherin-1 (PCDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[24]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[584]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[329]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[110]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]

Drug(s) Affected By Interleukin-10 receptor subunit beta (IL10RB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[296]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[557]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[676]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[39]

Drug(s) Affected By CMRF35-like molecule 6 (CD300C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[187]

Drug(s) Affected By Histone-binding protein RBBP4 (RBBP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[159]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[159]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[88]

Drug(s) Affected By Neuroblast differentiation-associated protein AHNAK (AHNAK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[301]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]

Drug(s) Affected By Bone marrow stromal antigen 2 (BST2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[298]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[124]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[128]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[124]

Drug(s) Affected By Tastin (TROAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[571]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[110]

Drug(s) Affected By Nucleosome-remodeling factor subunit BPTF (BPTF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[523]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[298]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[382]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]

Drug(s) Affected By Interleukin enhancer-binding factor 3 (ILF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[88]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[39]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[419]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[677]

Drug(s) Affected By Transcription initiation factor TFIID subunit 10 (TAF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[37]

Drug(s) Affected By PR domain zinc finger protein 2 (PRDM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[678]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[329]
Bortezomib	DMNO38U	Leukemia		Approved	[90]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[679]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[164]

Drug(s) Affected By Lymphocyte cytosolic protein 2 (LCP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[152]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[644]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By Krueppel-like factor 10 (KLF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[196]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[118]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[100]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[329]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[622]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]

Drug(s) Affected By Liprin-alpha-1 (PPFIA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[43]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[39]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By Serine/threonine-protein kinase PAK 1 (PAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[680]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[681]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[682]

Drug(s) Affected By Serine/threonine-protein kinase PAK 2 (PAK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[174]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[73]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]

Drug(s) Affected By Chromobox protein homolog 3 (CBX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[245]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[245]
Bortezomib	DMNO38U	Leukemia		Approved	[90]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]

Drug(s) Affected By DNA excision repair protein ERCC-8 (ERCC8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[548]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[683]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[684]

Drug(s) Affected By Src-like-adapter (SLA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[145]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[403]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[91]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[91]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[107]

Drug(s) Affected By Voltage-gated potassium channel subunit beta-2 (KCNAB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[107]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[685]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[40]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[40]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[685]

Drug(s) Affected By S-phase kinase-associated protein 2 (SKP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[246]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[99]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[686]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[687]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]

Drug(s) Affected By Metastasis-associated protein MTA1 (MTA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[19]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[688]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[248]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[689]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[675]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[209]

Drug(s) Affected By Origin recognition complex subunit 2 (ORC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[209]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[690]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[160]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[157]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[82]

Drug(s) Affected By Integrin-linked protein kinase (ILK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[593]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[264]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[691]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[692]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]

Drug(s) Affected By DNA-binding protein Ikaros (IKZF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[145]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Bortezomib	DMNO38U	Leukemia		Approved	[90]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[106]
Vitamin C	DMXJ7O8	Adenocarcinoma	2D40	Approved	[693]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[82]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[694]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[695]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[696]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[697]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[698]

Drug(s) Affected By Mothers against decapentaplegic homolog 4 (SMAD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[699]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[691]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[597]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]

Drug(s) Affected By V-type proton ATPase 116 kDa subunit a 3 (TCIRG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[509]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[39]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[93]

Drug(s) Affected By Mediator of RNA polymerase II transcription subunit 21 (MED21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[88]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[110]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[39]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[40]

Drug(s) Affected By Cullin-1 (CUL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[211]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[306]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Bortezomib	DMNO38U	Leukemia		Approved	[700]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[701]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By Ras-related protein Rab-31 (RAB31)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[21]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[21]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]

Drug(s) Affected By Bleomycin hydrolase (BLMH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[702]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[200]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[703]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]

Drug(s) Affected By Krueppel-like factor 9 (KLF9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[196]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[158]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[173]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[158]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[158]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[382]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]

Drug(s) Affected By Runt-related transcription factor 2 (RUNX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[345]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[704]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[705]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[706]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[707]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[708]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[21]

Drug(s) Affected By Calcium/calmodulin-dependent protein kinase type 1 (CAMK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[555]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[40]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[709]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[710]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]

Drug(s) Affected By Eukaryotic translation initiation factor 3 subunit A (EIF3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[290]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[73]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[308]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[110]

Drug(s) Affected By Transcription factor Dp-1 (TFDP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[540]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[514]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[711]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[174]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[507]

Drug(s) Affected By Transcription factor Dp-2 (TFDP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[174]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[163]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[123]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[190]

Drug(s) Affected By Eukaryotic initiation factor 4A-II (EIF4A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[562]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[163]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[73]

Drug(s) Affected By Adhesion G protein-coupled receptor E1 (ADGRE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[194]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[93]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[297]

Drug(s) Affected By E3 ubiquitin/ISG15 ligase TRIM25 (TRIM25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[122]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[712]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]

Drug(s) Affected By Protein-tyrosine kinase 2-beta (PTK2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[713]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[714]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[270]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[562]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[403]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[110]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[44]

Drug(s) Affected By Caprin-1 (CAPRIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[715]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[90]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[716]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[163]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[161]

Drug(s) Affected By Protocadherin Fat 1 (FAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[303]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[528]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[319]

Drug(s) Affected By Inositol 1,4,5-trisphosphate receptor type 2 (ITPR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[717]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]

Drug(s) Affected By Inositol 1,4,5-trisphosphate receptor type 3 (ITPR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]

Drug(s) Affected By Pumilio homolog 1 (PUM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[718]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[44]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[157]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[157]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[583]

Drug(s) Affected By Nuclear receptor coactivator 6 (NCOA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[129]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[129]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[44]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[583]
[3H]methyltrienolone	DMTSGOW	Discovery agent	N.A.	Investigative	[719]

Drug(s) Affected By Phosphatidate phosphatase LPIN1 (LPIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[720]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[721]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[90]

Drug(s) Affected By H2.0-like homeobox protein (HLX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[32]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[107]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[39]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID27336223-Compound-5	DM6E50A	N. A.	N. A.	Patented	[32]

Drug(s) Affected By LIM and SH3 domain protein 1 (LASP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[722]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[723]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[161]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]

Drug(s) Affected By Rab3 GTPase-activating protein catalytic subunit (RAB3GAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[62]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[157]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[184]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[566]

Drug(s) Affected By Bromodomain-containing protein 3 (BRD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[129]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[724]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[725]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[61]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[157]

Drug(s) Affected By Cyclin-dependent kinase 10 (CDK10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[48]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[640]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[326]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[110]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[726]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[727]

Drug(s) Affected By Ras-related protein Rab-35 (RAB35)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[209]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[110]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[44]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[79]

Drug(s) Affected By P2Y purinoceptor 14 (P2RY14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[675]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[454]

Drug(s) Affected By Surfeit locus protein 1 (SURF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[728]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[539]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[729]

Drug(s) Affected By Protein SSXT (SS18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[90]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[82]

Drug(s) Affected By Homeobox protein TGIF1 (TGIF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[730]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[264]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[731]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[88]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]

Drug(s) Affected By 2'-5'-oligoadenylate synthase-like protein (OASL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[124]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[100]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[184]

Drug(s) Affected By Leukotriene B4 receptor 1 (LTB4R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[249]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[145]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[681]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[106]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[732]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
BRN-3548355	DM4KXT0	N. A.	N. A.	Investigative	[733]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[82]

Drug(s) Affected By Mothers against decapentaplegic homolog 2 (SMAD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[289]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[699]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[707]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[734]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[689]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[689]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[728]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[735]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[211]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[230]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[736]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[737]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[738]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[739]

Drug(s) Affected By Serine/threonine-protein kinase N1 (PKN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[93]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[37]

Drug(s) Affected By Mitogen-activated protein kinase 14 (MAPK14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[740]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[728]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[741]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[742]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[743]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[103]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[744]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[745]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[746]

Drug(s) Affected By Bcl-2-related protein A1 (BCL2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[747]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[124]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[173]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[547]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[748]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[749]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[124]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[147]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]

Drug(s) Affected By Lymphocyte antigen 6E (LY6E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[124]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[124]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[124]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[124]

Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[750]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[48]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[751]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[752]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[753]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[754]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[755]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[756]

Drug(s) Affected By Protein NKG7 (NKG7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[264]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[178]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[106]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[658]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[93]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE	DMNQL17	Discovery agent	N.A.	Investigative	[757]

Drug(s) Affected By Transcription factor NF-E2 45 kDa subunit (NFE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[758]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Aclarubicin	DMLFZHD	Acute myeloid leukaemia	2A60	Approved	[759]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[296]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[296]
Pomalidomide	DMTGBAX	Plasma cell myeloma	2A83.1	Approved	[760]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[161]

Drug(s) Affected By Syntaxin-1A (STX1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]

Drug(s) Affected By Gamma-interferon-inducible protein 16 (IFI16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[289]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[298]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[761]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase-like N (PTPRN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[303]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[145]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[329]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[434]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]

Drug(s) Affected By Bridge-like lipid transfer protein family member 1 (BLTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[762]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[120]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[187]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[157]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[420]

Drug(s) Affected By Erythroid differentiation-related factor 1 (EDRF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[455]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[643]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[607]

Drug(s) Affected By B-cell CLL/lymphoma 7 protein family member A (BCL7A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Bortezomib	DMNO38U	Leukemia		Approved	[90]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[434]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[109]

Drug(s) Affected By Coiled-coil domain-containing protein 93 (CCDC93)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[435]

Drug(s) Affected By Protein THEMIS2 (THEMIS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[303]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[190]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[44]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[49]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[135]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[93]

Drug(s) Affected By Telomere-associated protein RIF1 (RIF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[114]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[658]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[44]

Drug(s) Affected By Centrosomal protein of 135 kDa (CEP135)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[183]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[185]

Drug(s) Affected By Histone H2A type 2-A (H2AC18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[436]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[91]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[62]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]

Drug(s) Affected By Activity-dependent neuroprotector homeobox protein 2 (ADNP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[701]
Lithium	DMZ3OU6	Bipolar disorder	6A60	Phase 2	[155]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[583]

Drug(s) Affected By Proton-coupled amino acid transporter 1 (SLC36A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[110]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[297]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[78]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[109]

Drug(s) Affected By Transmembrane channel-like protein 6 (TMC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[126]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[763]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[562]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[507]

Drug(s) Affected By SUZ domain-containing protein 1 (SZRD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[470]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[110]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[39]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By Serine incorporator 5 (SERINC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[163]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[107]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[44]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[120]

Drug(s) Affected By Homeodomain-interacting protein kinase 1 (HIPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[304]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[382]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[304]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[190]

Drug(s) Affected By Structural maintenance of chromosomes protein 5 (SMC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[683]

Drug(s) Affected By Leukocyte immunoglobulin-like receptor subfamily A member 2 (LILRA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[264]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[764]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[310]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[765]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By Leucine repeat adapter protein 25 (FAM89B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[62]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[71]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[120]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[186]

Drug(s) Affected By ATP synthase mitochondrial F1 complex assembly factor 2 (ATPAF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[80]

Drug(s) Affected By Leukocyte immunoglobulin-like receptor subfamily A member 3 (LILRA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[45]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By ATP-dependent RNA helicase DDX51 (DDX51)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[43]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[63]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]

Drug(s) Affected By Saccharopine dehydrogenase-like oxidoreductase (SCCPDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[159]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[766]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]

Drug(s) Affected By SERPINE1 mRNA-binding protein 1 (SERBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[62]

Drug(s) Affected By Protein LSM14 homolog A (LSM14A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[62]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[129]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[187]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]

Drug(s) Affected By Nuclear protein MDM1 (MDM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[36]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[507]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]

Drug(s) Affected By Centrosome-associated protein ALMS1 (ALMS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[43]

Drug(s) Affected By GATA zinc finger domain-containing protein 1 (GATAD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[71]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[93]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[61]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[767]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[768]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[179]

Drug(s) Affected By Transmembrane 9 superfamily member 4 (TM9SF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[129]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By Phytanoyl-CoA hydroxylase-interacting protein (PHYHIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[562]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[297]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[769]

Drug(s) Affected By TBC1 domain family member 5 (TBC1D5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[129]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[24]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[129]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[770]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By Rho GTPase-activating protein 45 (ARHGAP45)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[406]
Acetazolamide	DM1AF5U	Absence epilepsy		Approved	[406]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Brinzolamide	DMBAPFG	Ocular hypertension	9C61.01	Approved	[406]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Indapamide	DMGN1PW	Edema	MG29	Approved	[406]
Cefepime	DMHVWIK	Bacterial infection	1A00-1C4Z	Approved	[406]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[329]

Drug(s) Affected By Symplekin (SYMPK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[110]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[453]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[771]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[44]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[771]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[61]

Drug(s) Affected By NEDD4-binding protein 2-like 2 (N4BP2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[184]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]

Drug(s) Affected By TATA-binding protein-associated factor 2N (TAF15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[144]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[129]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[36]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[62]

Drug(s) Affected By DNA repair protein RAD50 (RAD50)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[196]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[261]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[281]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[711]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[127]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[183]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]

Drug(s) Affected By CUGBP Elav-like family member 1 (CELF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]

Drug(s) Affected By SWI/SNF complex subunit SMARCC1 (SMARCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[772]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[414]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[773]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[71]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[162]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 14 (TNFRSF14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[250]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[711]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[774]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[775]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[174]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]

Drug(s) Affected By Transportin-1 (TNPO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[301]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]

Drug(s) Affected By Interferon regulatory factor 7 (IRF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[124]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[776]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[777]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[100]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[124]

Drug(s) Affected By Histone acetyltransferase KAT5 (KAT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[778]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[452]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[779]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[606]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[780]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[452]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[781]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[61]

Drug(s) Affected By V-type proton ATPase 116 kDa subunit a 1 (ATP6V0A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[782]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[63]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[44]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By Interferon-stimulated gene 20 kDa protein (ISG20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[124]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[783]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[124]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[100]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[124]

Drug(s) Affected By Signal-induced proliferation-associated protein 1 (SIPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[93]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[157]

Drug(s) Affected By Macrophage immunometabolism regulator (MACIR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[157]

Drug(s) Affected By Ataxin-7-like protein 3B (ATXN7L3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[39]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[44]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[784]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[607]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[85]

Drug(s) Affected By Tribbles homolog 1 (TRIB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[246]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[126]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]

Drug(s) Affected By Plakophilin-4 (PKP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Indomethacin	DMSC4A7	Bursitis		Approved	[83]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]

Drug(s) Affected By Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[785]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[675]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[329]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[88]

Drug(s) Affected By Cell division control protein 6 homolog (CDC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[540]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[143]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[244]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[555]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[543]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]

Drug(s) Affected By Myeloid differentiation primary response protein MyD88 (MYD88)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[226]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[523]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[304]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[711]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[304]

Drug(s) Affected By A-kinase anchor protein 9 (AKAP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[183]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[62]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[786]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]

Drug(s) Affected By Protein NipSnap homolog 1 (NIPSNAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[298]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[317]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Bortezomib	DMNO38U	Leukemia		Approved	[90]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[606]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[164]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]

Drug(s) Affected By Mitochondrial ribosome-associated GTPase 1 (MTG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[728]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[123]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[129]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[179]

Drug(s) Affected By Eukaryotic translation initiation factor 2A (EIF2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[599]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[787]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[788]
Cerulenin	DM6N4PR	Weight loss	MG43.5	Approved	[789]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[131]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[652]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]

Drug(s) Affected By Cell adhesion molecule 1 (CADM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[455]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[790]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[507]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[791]

Drug(s) Affected By 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 (DPH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[62]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[61]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]

Drug(s) Affected By B-cell lymphoma/leukemia 11A (BCL11A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[310]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[106]

Drug(s) Affected By Pinin (PNN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[689]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[689]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[62]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[88]

Drug(s) Affected By Tudor domain-containing protein 3 (TDRD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[296]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[296]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[110]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[40]

Drug(s) Affected By Polyamine-transporting ATPase 13A3 (ATP13A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[114]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[39]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[63]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[157]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[85]

Drug(s) Affected By E3 ubiquitin-protein transferase RMND5A (RMND5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[190]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[44]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By Pantothenate kinase 3 (PANK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[720]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[91]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[160]

Drug(s) Affected By Glyoxalase domain-containing protein 4 (GLOD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[792]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[793]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[792]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[792]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[792]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]

Drug(s) Affected By DNA polymerase delta subunit 4 (POLD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[548]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[562]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[507]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]

Drug(s) Affected By Nucleolar RNA helicase 2 (DDX21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[301]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[122]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[301]

Drug(s) Affected By Structural maintenance of chromosomes protein 4 (SMC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[794]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[509]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[28]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]

Drug(s) Affected By Midasin (MDN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[134]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[114]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[44]

Drug(s) Affected By Septin-11 (SEPTIN11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[324]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[43]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[108]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]

Drug(s) Affected By ATP-dependent RNA helicase DDX18 (DDX18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[577]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[509]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[43]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[71]

Drug(s) Affected By Spermine oxidase (SMOX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[336]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[336]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Mestranol	DMG3F94	Contraception	QA21	Approved	[336]

Drug(s) Affected By Bcl-2-associated transcription factor 1 (BCLAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[452]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[24]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[795]

Drug(s) Affected By Regulator of telomere elongation helicase 1 (RTEL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[796]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[91]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[44]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[157]

Drug(s) Affected By Sacsin (SACS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[129]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[110]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[37]

Drug(s) Affected By Alpha-catulin (CTNNAL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[244]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[548]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[675]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]

Drug(s) Affected By Lysine-specific demethylase 5B (KDM5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[264]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[797]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[562]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]

Drug(s) Affected By Deleted in malignant brain tumors 1 protein (DMBT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[798]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[40]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[420]

Drug(s) Affected By CMRF35-like molecule 8 (CD300A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[145]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[358]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[32]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[799]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[107]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[93]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By Death-associated protein kinase 2 (DAPK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[800]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[174]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[329]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[649]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[801]

Drug(s) Affected By Testis-specific Y-encoded-like protein 4 (TSPYL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[63]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[44]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
Nickel chloride	DMI12Y8	Discovery agent	N.A.	Investigative	[802]

Drug(s) Affected By Phospholipase A and acyltransferase 4 (PLAAT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[126]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[178]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[18]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]

Drug(s) Affected By Proteasome activator complex subunit 2 (PSME2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[289]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[122]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[106]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
MG-132	DMKA2YS	N. A.	N. A.	Preclinical	[803]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[804]

Drug(s) Affected By Histone-lysine N-methyltransferase 2B (KMT2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[797]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[201]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[71]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[157]

Drug(s) Affected By Nuclear pore complex-interacting protein family member A1 (NPIPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[88]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[683]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[109]
crotylaldehyde	DMTWRQI	Discovery agent	N.A.	Investigative	[805]

Drug(s) Affected By Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (MACF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]

Drug(s) Affected By E3 ubiquitin-protein ligase TRIM33 (TRIM33)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[110]
Fenretinide	DMRD5SP	Macular degeneration	9B78.3	Phase 3	[806]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[61]

Drug(s) Affected By Myotubularin-related protein 6 (MTMR6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[118]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Bortezomib	DMNO38U	Leukemia		Approved	[90]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[807]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[39]

Drug(s) Affected By PALM2-AKAP2 fusion protein (PALM2AKAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[269]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[403]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[272]

Drug(s) Affected By Little elongation complex subunit 1 (ICE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[110]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[808]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]

Drug(s) Affected By 1-phosphatidylinositol 3-phosphate 5-kinase (PIKFYVE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[106]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[44]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[582]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[157]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[80]
Hexadecanoic acid	DMWUXDZ	Discovery agent	N.A.	Investigative	[809]

Drug(s) Affected By Rhomboid domain-containing protein 3 (RHBDD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[62]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]

Drug(s) Affected By V-type proton ATPase 116 kDa subunit a 2 (ATP6V0A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[810]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[43]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[191]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[49]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By Transformation/transcription domain-associated protein (TRRAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Bortezomib	DMNO38U	Leukemia		Approved	[90]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[272]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[62]

Drug(s) Affected By Disheveled-associated activator of morphogenesis 1 (DAAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[179]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[44]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[811]

Drug(s) Affected By Diacylglycerol lipase-alpha (DAGLA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[812]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[63]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[566]
ACEA	DMWX3HT	Discovery agent	N.A.	Investigative	[813]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF115 (RNF115)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[163]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[161]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[814]

Drug(s) Affected By Protein PRRC2C (PRRC2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[178]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]

Drug(s) Affected By Sodium bicarbonate cotransporter 3 (SLC4A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[382]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]

Drug(s) Affected By ATPase MORC2 (MORC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Bortezomib	DMNO38U	Leukemia		Approved	[90]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[63]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[61]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[157]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[157]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[109]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[815]

Drug(s) Affected By TNF receptor-associated factor 5 (TRAF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[298]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[711]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[597]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[174]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[87]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[106]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[726]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[816]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By SH2B adapter protein 2 (SH2B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[562]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[184]

Drug(s) Affected By Interleukin-1 receptor-associated kinase-like 2 (IRAK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[100]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[817]

Drug(s) Affected By SH2 domain-containing protein 1A (SH2D1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[97]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[329]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[144]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[211]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[818]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[99]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[548]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[126]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[619]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[178]

Drug(s) Affected By HLA class II histocompatibility antigen, DR alpha chain (HLA-DRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[819]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[100]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[820]

Drug(s) Affected By HLA class II histocompatibility antigen, DQ beta 1 chain (HLA-DQB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[821]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[406]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[406]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[106]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[343]
Ticlopidine	DMO946V	Acute coronary syndrome	BA41	Approved	[344]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[406]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[549]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]

Drug(s) Affected By HLA class II histocompatibility antigen gamma chain (CD74)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[822]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[406]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[264]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[124]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[823]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[246]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[824]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[825]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[227]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[225]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[231]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[826]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[124]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase C (PTPRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[132]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[827]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[145]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[828]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[91]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[106]

Drug(s) Affected By Lysosomal protective protein (CTSA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]

Drug(s) Affected By B-cell antigen receptor complex-associated protein alpha chain (CD79A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Bortezomib	DMNO38U	Leukemia		Approved	[90]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[110]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[116]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[829]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[82]
Rutin	DMEHRAJ	Discovery agent	N.A.	Investigative	[830]

Drug(s) Affected By CD44 antigen (CD44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[226]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[336]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Selenium	DM25CGV	N. A.	N. A.	Approved	[831]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[832]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[833]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[834]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[835]

Drug(s) Affected By cAMP-dependent protein kinase catalytic subunit alpha (PRKACA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[727]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[44]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[49]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[93]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[187]

Drug(s) Affected By Transcription factor EB (TFEB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[836]
Prochlorperazine	DM53SRA	Nausea	MD90	Approved	[836]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[837]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[838]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[839]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[39]

Drug(s) Affected By HLA class II histocompatibility antigen, DP alpha 1 chain (HLA-DPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[406]
Cinoxacin	DM4EWNS	Urinary tract infection	GC08	Approved	[406]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Valdecoxib	DMAY7H4	Osteoarthritis	FA00-FA05	Approved	[406]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Cephalexin	DMD5JU8	Acute otitis media	AB00	Approved	[406]

Drug(s) Affected By Midkine (MDK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[840]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[841]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[184]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[649]

Drug(s) Affected By Myeloblastin (PRTN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[457]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[269]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Pazopanib	DMF57DM	N. A.	N. A.	Approved	[842]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[110]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[582]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[521]

Drug(s) Affected By Integrin alpha-3 (ITGA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[48]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[775]

Drug(s) Affected By Protein S100-A4 (S100A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[298]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[717]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[544]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[843]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]

Drug(s) Affected By HLA class II histocompatibility antigen, DM beta chain (HLA-DMB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Topiramate	DM82Z30	Alcohol dependence	6C40.2	Approved	[406]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[145]
Valdecoxib	DMAY7H4	Osteoarthritis	FA00-FA05	Approved	[406]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Ethosuximide	DMDZ9LT	Epilepsy	8A60-8A68	Approved	[406]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Vancomycin	DM3JFIH	Bacteremia	1A73	Approved	[406]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[844]
Bortezomib	DMNO38U	Leukemia		Approved	[90]

Drug(s) Affected By Sorcin (SRI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[845]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[163]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[846]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[62]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]

Drug(s) Affected By MHC class II transactivator (CIITA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[406]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[847]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[848]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[847]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[147]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[681]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[849]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[850]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[577]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[366]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[851]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[505]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[563]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[852]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[853]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[854]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[143]

Drug(s) Affected By MAP kinase-activated protein kinase 2 (MAPKAPK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[855]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[742]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[249]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[856]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[855]
Bortezomib	DMNO38U	Leukemia		Approved	[90]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[846]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[106]

Drug(s) Affected By Rho GTPase-activating protein 8 (ARHGAP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[119]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[71]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[45]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[565]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[35]

Drug(s) Affected By Transcription factor RelB (RELB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[608]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[211]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[555]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[304]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[619]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[27]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 17 (TNFRSF17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[304]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[711]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[304]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[174]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[857]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[858]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[82]

Drug(s) Affected By Lactadherin (MFGE8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[174]
Methyl aminolevulinate	DMIUX3D	Acne vulgaris	ED80	Approved	[859]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[86]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[860]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[62]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[857]

Drug(s) Affected By HLA class II histocompatibility antigen, DR beta 5 chain (HLA-DRB5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[861]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[862]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[603]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[861]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[40]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[521]

Drug(s) Affected By Ras association domain-containing protein 6 (RASSF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[863]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[35]

Drug(s) Affected By Rho-related GTP-binding protein RhoU (RHOU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[191]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[526]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[134]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[296]

Drug(s) Affected By Protein lifeguard 1 (GRINA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Selenium	DM25CGV	N. A.	N. A.	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[163]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[110]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[718]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[114]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase kinase 1 (MAP4K1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[555]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[32]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[296]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[296]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[129]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[39]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[558]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]

Drug(s) Affected By P2X purinoceptor 5 (P2RX5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[43]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[49]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[93]

Drug(s) Affected By Ankyrin repeat and SOCS box protein 2 (ASB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[681]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[864]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[107]

Drug(s) Affected By Leucine zipper transcription factor-like protein 1 (LZTFL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[165]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[43]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[864]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]

Drug(s) Affected By SLC2A4 regulator (SLC2A4RG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[62]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[93]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[37]

Drug(s) Affected By Phospholipase A and acyltransferase 2 (PLAAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[581]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[82]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[865]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[769]

Drug(s) Affected By Plexin-A1 (PLXNA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[137]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[179]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[47]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[80]

Drug(s) Affected By Nuclear receptor corepressor 2 (NCOR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[30]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[62]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[68]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[866]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[61]

Drug(s) Affected By Dual specificity protein phosphatase 10 (DUSP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[211]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[742]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[448]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[245]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[448]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[619]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]

Drug(s) Affected By Estrogen receptor (ESR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[867]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[503]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[868]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[869]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[870]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[871]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[872]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[873]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[869]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[874]

Drug(s) Affected By Integrin beta-2 (ITGB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[875]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[876]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[358]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]

Drug(s) Affected By Thrombomodulin (THBD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[184]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[655]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[549]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[85]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[145]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[877]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[271]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[878]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[879]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[880]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[881]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[201]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[246]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[882]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[632]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[221]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[502]

Drug(s) Affected By Tissue factor (F3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[883]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[884]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[885]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[886]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[887]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[888]
Fructose	DM43AN2	Vomiting	MD90	Approved	[889]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[890]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[884]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[269]

Drug(s) Affected By Insulin-like growth factor-binding protein 3 (IGFBP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[80]
Selenium	DM25CGV	N. A.	N. A.	Approved	[891]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[892]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[893]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[245]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[102]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[49]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[894]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[451]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[18]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[563]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[635]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[895]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[896]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[348]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[897]
Fructose	DM43AN2	Vomiting	MD90	Approved	[889]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[448]

Drug(s) Affected By Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[549]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[845]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[898]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[899]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[900]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[732]
Coprexa	DMA0WEK	Neurological disorder	6B60	Phase 3	[92]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[45]

Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PIK3CG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[901]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[578]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[902]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[903]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[904]
GDC0941	DM1YAK6	Breast cancer	2C60-2C65	Phase 2	[905]
GDC-0980/RG7422	DMF3MV1	Non-hodgkin lymphoma	2B33.5	Phase 2	[906]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[710]

Drug(s) Affected By Transforming growth factor beta-2 proprotein (TGFB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[467]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[72]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[907]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[908]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[27]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[691]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[29]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]

Drug(s) Affected By CCAAT/enhancer-binding protein epsilon (CEBPE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[125]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[58]
Pomalidomide	DMTGBAX	Plasma cell myeloma	2A83.1	Approved	[760]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[909]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[521]
Caffeic acid phenethyl ester	DMRJKIV	Discovery agent	N.A.	Investigative	[910]

Drug(s) Affected By Occludin (OCLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[911]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[912]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[913]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[914]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[915]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[145]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[916]

Drug(s) Affected By Bile acid receptor (NR1H4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[154]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[917]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[918]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[919]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[695]
Nisoldipine	DM7ISKJ	Hypertension	BA00-BA04	Approved	[917]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[918]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[920]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[37]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Retinoic acid receptor alpha (RARA)	TTW38KT	RARA_HUMAN	Modulator	[3]
Retinoic acid receptor beta (RARB)	TTISP28	RARB_HUMAN	Modulator	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1-phosphatidylinositol 3-phosphate 5-kinase (PIKFYVE)	OTO3HGAA	FYV1_HUMAN	Gene/Protein Processing	[4]
14-3-3 protein zeta/delta	OT2TKG9P	1433Z_HUMAN	Gene/Protein Processing	[4]
15-hydroxyprostaglandin dehydrogenase (HPGD)	OTYZI6JB	PGDH_HUMAN	Gene/Protein Processing	[4]
2'-5'-oligoadenylate synthase 1 (OAS1)	OT8ZLOCY	OAS1_HUMAN	Gene/Protein Processing	[4]
2'-5'-oligoadenylate synthase 2 (OAS2)	OT64CCTM	OAS2_HUMAN	Gene/Protein Processing	[4]
2'-5'-oligoadenylate synthase-like protein (OASL)	OTZ05YRP	OASL_HUMAN	Gene/Protein Processing	[4]
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 (DPH1)	OT0QU3JY	DPH1_HUMAN	Gene/Protein Processing	[4]
4-hydroxyphenylpyruvate dioxygenase (HPD)	OTDKD5EH	HPPD_HUMAN	Gene/Protein Processing	[4]
5-aminolevulinate synthase, non-specific, mitochondrial (ALAS1)	OTQY6ZSF	HEM1_HUMAN	Gene/Protein Processing	[4]
6-phosphogluconate dehydrogenase, decarboxylating (PGD)	OTVG296F	6PGD_HUMAN	Gene/Protein Processing	[4]

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