Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZD5QR)

• Drug Name: Cytarabine Drug Info
• Synonyms: Alexan; AraC; Arabinocytidine; Arabinofuranosylcytosine; Arabinosylcytosine; Arabitin; Aracytidine; Aracytin; Aracytine; Arafcyt; Citarabina; Cytarabin; Cytarabina; Cytarabinoside; Cytarabinum; Cytarbel; Cytonal; Cytosar; Cytosinearabinoside; DepoCyte; Depocyt; Erpalfa; Iretin; Spongocytidine; Tarabine; Udicil; Arabinosyl Cytosine; Cytarabine liposome injection; Cytosine arabinofuranoside; Cytosine arabinose; Cytosine arabinoside; AR3; BTB15125; CHX 3311; U 19920A; Ara-C; Ara-Cytidine; Beta-Ara C; Beta-Arabinosylcytosine; Beta-cytosine arabinoside; Citarabina [INN-Spanish]; Cytarabinum [INN-Latin]; Cytosar-U; Cytosine arabinoside (VAN); Depocyt (TN); Depocyt (liposomal); Intrathecal (injected into the spinal fluid) DepoCyt; U-19920; Beta-D-Arabinosylcytosine; Cytosar-U (TN); Cytosine beta-D-arabinofuranoside; Cytosine beta-D-arabinofuranoside hydrochloride; Cytosine beta-D-arabinoside; Cytosine-beta-arabinoside; Intrathecal cytarabine (also known as ara-C); U-19,920; CYTARABINE (SEE ALSO CYTARABINE HYDROCHLORIDE 69-74-9); Cytarabine (JP15/USP/INN); Cytarabine [USAN:INN:BAN:JAN]; Cytosine 1-beta-D-arabinofuranoside; Cytosine, beta-D-arabinoside; Cytosine-beta-D-arabinofuranoside; Cytosine-1-beta-D-arabinofuranoside; Ara-C, Cytosine Arabinoside, Cytosar-U, Cytarabine; (beta-D-Arabinofuranosyl)cytosine; 1-.beta.-D-arabinofuranosyl-cytosine; 1-Arabinofuranosylcytosine; 1-beta-D-Arabinofaranosylcytosine; 1-beta-D-Arabinofuranosyl-4-amino-2(1H)pyrimidinone; 1-beta-D-Arabinofuranosylcytosine; 1-beta-D-Arabinofuranosylcytosine, Cytosine Arabinoside; 1-beta-D-Arabinosylcytosine; 1beta-Arabinofuranasylcytosine; 1beta-D-Arabinofuranosylcytosine; 1beta-D-Arabinosylcytosine; 2(1H)-Pyrimidinone, 4-amino-1-D-arabinofuranosyl-[CAS]; 4-Amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidin; 4-Amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidin [Czech]; 4-Amino-1-arabinofuranosyl-2-oxo-1,2-dihydropyrimidine; 4-Amino-1-b-D-arabinofuranosyl-2-(1H)-pyrimidinone; 4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinon; 4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinon [Czech]; 4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone; 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one; 4-amino-1-beta-D-arabinofuranosylpyrimidin-2(1H)-one

Indication

Disease Entry	ICD 11	Status	REF
Acute lymphoblastic leukaemia	2A85	Approved	[1]
Acute myelogenous leukaemia	2A41	Approved	[2]
Adult acute monocytic leukemia		Approved	[2]
Childhood acute megakaryoblastic leukemia		Approved	[2]
Plasma cell myeloma	2A83.1	Approved	[2]
Neoplastic meningitis		Investigative	[2]

• Therapeutic Class: Anticancer Agents
• Cross-matching ID:
  PubChem CID: 6253
  ChEBI ID: CHEBI:28680
  CAS Number: CAS 147-94-4
  TTD Drug ID: DMZD5QR
  VARIDT Drug ID: DR00416
  INTEDE Drug ID: DR0398
  ACDINA Drug ID: D00976

Molecule-Related Drug Atlas

Drug(s) Targeting Herpes simplex virus DNA polymerase UL30 (HSV UL30)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aciclovir	DMYLOVR	Genital herpes	1A94	Approved	[14]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[15]
Valaciclovir	DMHKS94	Genital herpes	1A94	Approved	[16]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[14]
Valganciclovir	DMS2IUH	Virus infection	1A24-1D9Z	Approved	[17]
Penciclovir	DMOUMDV	Herpes simplex labialis	1F00.01	Approved	[18]
Famciclovir	DMJHLSD	Meniere disease	AB31.0	Approved	[19]
Valacyclovir Hydrochloride	DM5I1CE	Herpes simplex virus infection	1F00	Approved	[14]
Foscavir	DM9KJLZ	Cytomegalovirus retinitis	9B72.00	Approved	[17]
Netivudine	DMTKRY1	Virus infection	1A24-1D9Z	Phase 3	[20]

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[6]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[21]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[7]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[22]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[7]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[7]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[23]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[7]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[24]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[25]

Drug(s) Transported By Organic cation transporter 1 (SLC22A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[29]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[6]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[30]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[31]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[32]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[33]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[34]

Drug(s) Transported By Organic cation/carnitine transporter 1 (SLC22A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[35]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[35]
Levacecarnine hci	DMJBOCR	Cognitive impairment	6D71	Approved	[36]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[37]
Ipratropium	DMFQ320	Obstructive lung disease	CA22.Z	Approved	[38]
[14C]TEA	DM6SFYH	Discovery agent	N.A.	Investigative	[39]

Drug(s) Transported By Concentrative nucleoside transporter 1 (SLC28A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[40]
Uridine	DMQTREB	Depression	6A70-6A7Z	Approved	[41]
Trifluridine	DMG2YBD	Herpetic keratitis	1F00.10	Approved	[42]

Drug(s) Transported By Equilibrative nucleoside transporter 1 (SLC29A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[43]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[44]
Entecavir	DM7VTQO	Hepatitis B virus infection	1E51.0	Approved	[45]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[46]
Clofarabine	DMCVJ86	Acute lymphoblastic leukaemia	2A85	Approved	[47]
Trifluridine	DMG2YBD	Herpetic keratitis	1F00.10	Approved	[42]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[48]
Tecadenoson	DM9T6MS	Atrial fibrillation	BC81.3	Discontinued in Phase 3	[49]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[72]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[73]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[76]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[77]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]

Drug(s) Transported By Equilibrative nucleoside transporter 2 (SLC29A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[44]
Entecavir	DM7VTQO	Hepatitis B virus infection	1E51.0	Approved	[45]
Clofarabine	DMCVJ86	Acute lymphoblastic leukaemia	2A85	Approved	[47]
Trifluridine	DMG2YBD	Herpetic keratitis	1F00.10	Approved	[42]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[50]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[51]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[52]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[53]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[54]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[55]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[56]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[57]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[51]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[58]

Drug(s) Metabolized By Cytidine aminohydrolase (CDA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[59]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[60]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[61]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[62]

Drug(s) Metabolized By Cytidine deaminase (cdd)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[10]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[10]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[10]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[63]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[64]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[65]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[66]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[67]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[68]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[69]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[70]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[71]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[69]

Drug(s) Affected By GTP-binding protein 1 (GTPBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Bortezomib	DMNO38U	Leukemia		Approved	[84]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[85]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[87]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[88]

Drug(s) Affected By Kinetochore protein NDC80 homolog (NDC80)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[89]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]

Drug(s) Affected By Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[101]

Drug(s) Affected By Lymphocyte antigen 75 (LY75)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[104]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[106]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[79]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[107]
cordycepin	DM72Y01	Discovery agent	N.A.	Investigative	[108]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[109]

Drug(s) Affected By ATP-dependent DNA helicase Q5 (RECQL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[112]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[85]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[88]

Drug(s) Affected By SLIT and NTRK-like protein 5 (SLITRK5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[117]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[101]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[118]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[119]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[109]

Drug(s) Affected By Dihydrofolate reductase (DHFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[120]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[121]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[122]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[124]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[125]
Ceftriaxone	DMCEW64	Acute gonococcal cervicitis		Approved	[122]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[126]

Drug(s) Affected By Alpha-1-antitrypsin (SERPINA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[129]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[132]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]

Drug(s) Affected By T-cell surface glycoprotein CD8 alpha chain (CD8A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[134]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[135]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
GSK618334	DMJPXZ4	Drug abuse	6C4G.1Z	Phase 1	[136]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[137]

Drug(s) Affected By Thy-1 membrane glycoprotein (THY1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[138]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[139]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[140]
Bortezomib	DMNO38U	Leukemia		Approved	[84]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[141]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[142]
Ximelegatran	DMU8ANS	Myocardial infarction	BA41-BA43	Approved	[143]

Drug(s) Affected By Serglycin (SRGN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[126]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[147]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[148]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]

Drug(s) Affected By Non-secretory ribonuclease (RNASE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[149]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Salmeterol	DMIEU69	Allergic asthma	CA23.0	Approved	[150]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[151]
Beclomethasone dipropionate	DM5NW1E	Allergic rhinitis	CA08.0	Phase 4	[150]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[87]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[152]

Drug(s) Affected By Low affinity immunoglobulin gamma Fc region receptor II-a (FCGR2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[153]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[154]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[156]
Cetuximab	DMLNCE0	Colorectal cancer	2B91.Z	Approved	[157]

Drug(s) Affected By Heat shock 70 kDa protein 6 (HSPA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[158]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[159]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[161]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[93]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[163]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[164]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]

Drug(s) Affected By Transcription factor E3 (TFE3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[135]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[165]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[165]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[165]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[166]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]

Drug(s) Affected By Protein S100-P (S100P)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[168]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[169]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[170]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[149]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[171]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[172]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[173]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]

Drug(s) Affected By Ribonucleoside-diphosphate reductase subunit M2 (RRM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[174]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[175]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[124]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]

Drug(s) Affected By Low affinity immunoglobulin gamma Fc region receptor II-c (FCGR2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[156]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[177]
cinnamaldehyde	DMZDUXG	Discovery agent	N.A.	Investigative	[178]

Drug(s) Affected By G protein-coupled receptor kinase 5 (GRK5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[181]

Drug(s) Affected By RNA-binding protein 34 (RBM34)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[182]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[182]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[182]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[85]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Adenine	DMZLHKJ	Malnutrition	5B50-5B71	Approved	[182]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]

Drug(s) Affected By Ectonucleoside triphosphate diphosphohydrolase 1 (ENTPD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[183]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[184]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[185]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[79]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[110]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[186]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[187]
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[188]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[189]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[190]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[192]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[193]

Drug(s) Affected By Breast cancer type 2 susceptibility protein (BRCA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[194]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[195]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[196]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[197]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[126]

Drug(s) Affected By Geranylgeranyl transferase type-2 subunit beta (RABGGTB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[199]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[87]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[176]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[200]

Drug(s) Affected By UV excision repair protein RAD23 homolog A (RAD23A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[201]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]

Drug(s) Affected By Ras-related protein Rab-5B (RAB5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[204]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[205]
Nickel chloride	DMI12Y8	Discovery agent	N.A.	Investigative	[206]

Drug(s) Affected By C-X-C chemokine receptor type 4 (CXCR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[187]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[207]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[208]
Carfilzomib	DM48K0X	Multiple myeloma	2A83	Approved	[209]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[207]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[210]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[211]

Drug(s) Affected By Lysozyme C (LYZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[213]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[145]
Glibenclamide	DM8JXPZ	Diabetic complication	5A2Y	Approved	[214]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[215]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[166]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[216]

Drug(s) Affected By Histone H4 (H4C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[160]
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[217]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[219]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[220]

Drug(s) Affected By DNA repair protein RAD51 homolog 1 (RAD51)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[175]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[89]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[221]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[222]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[223]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[224]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]

Drug(s) Affected By Dual specificity protein phosphatase 4 (DUSP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[225]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[126]

Drug(s) Affected By Src-like-adapter (SLA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[147]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[85]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[226]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[176]

Drug(s) Affected By Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 (ACAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[177]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[228]

Drug(s) Affected By Cytohesin-1 (CYTH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[229]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[230]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[85]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[151]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]

Drug(s) Affected By C3a anaphylatoxin chemotactic receptor (C3AR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[231]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[85]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[226]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[232]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[233]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[234]

Drug(s) Affected By Drebrin (DBN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[235]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[236]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[148]

Drug(s) Affected By DALR anticodon-binding domain-containing protein 3 (DALRD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[88]
Z-Pro-Prolinal	DM43O2U	Discovery agent	N.A.	Investigative	[237]

Drug(s) Affected By Equilibrative nucleobase transporter 1 (SLC43A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[170]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[207]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Bortezomib	DMNO38U	Leukemia		Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[207]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[85]

Drug(s) Affected By Glutathione S-transferase C-terminal domain-containing protein (GSTCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Bortezomib	DMNO38U	Leukemia		Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[238]

Drug(s) Affected By DENN domain-containing protein 1A (DENND1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[239]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[79]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[79]

Drug(s) Affected By Serine protease FAM111A (FAM111A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[126]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[240]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[241]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[85]

Drug(s) Affected By Proline-serine-threonine phosphatase-interacting protein 2 (PSTPIP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[242]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[243]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[117]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[177]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[107]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[244]

Drug(s) Affected By Partitioning defective 6 homolog alpha (PARD6A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[87]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[233]

Drug(s) Affected By Mediator of RNA polymerase II transcription subunit 9 (MED9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[245]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[95]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[246]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[228]

Drug(s) Affected By Phospholipid-transporting ATPase VD (ATP10D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[151]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[87]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[247]

Drug(s) Affected By Bridging integrator 2 (BIN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[117]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[177]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[234]

Drug(s) Affected By DNA dC->dU-editing enzyme APOBEC-3B (APOBEC3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[249]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[250]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]

Drug(s) Affected By Protein PRRC2C (PRRC2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[228]
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[88]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]

Drug(s) Affected By Odontogenic ameloblast-associated protein (ODAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[166]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[151]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[251]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[87]

Drug(s) Affected By Pleckstrin homology domain-containing family G member 3 (PLEKHG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[226]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[199]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[252]

Drug(s) Affected By Aldo-keto reductase family 1 member B15 (AKR1B15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[241]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[87]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[253]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
2,3-dihydroxypropanal	DMOWNB4	Discovery agent	N.A.	Investigative	[254]

Drug(s) Affected By Alternative prion protein (PRNP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[153]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[256]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[257]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[257]

Drug(s) Affected By Matrilin-2 (MATN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[170]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[258]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[241]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[259]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]

Drug(s) Affected By Homeobox protein Meis1 (MEIS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[187]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[187]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[187]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[117]

Drug(s) Affected By Gamma-aminobutyric acid receptor subunit pi (GABRP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[126]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[112]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[260]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[261]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[262]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]

Drug(s) Affected By Podocalyxin (PODXL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[235]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[165]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[165]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[263]

Drug(s) Affected By Sarcolipin (SLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[264]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[228]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[109]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[137]

Drug(s) Affected By Nuclear factor 1 B-type (NFIB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[239]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[265]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[226]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[266]

Drug(s) Affected By Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[267]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]

Drug(s) Affected By Heparan sulfate glucosamine 3-O-sulfotransferase 1 (HS3ST1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[268]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[101]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[269]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[270]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[262]

Drug(s) Affected By Tetraspanin-4 (TSPAN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[229]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[226]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[199]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[271]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[272]

Drug(s) Affected By Regulator of G-protein signaling 13 (RGS13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[273]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[274]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[275]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[106]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[101]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[126]

Drug(s) Affected By Surfeit locus protein 4 (SURF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[231]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[276]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[270]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[276]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[277]

Drug(s) Affected By Monocarboxylate transporter 4 (SLC16A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[76]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[278]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]

Drug(s) Affected By Prolyl 4-hydroxylase subunit alpha-2 (P4HA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vitamin C	DMXJ7O8	Adenocarcinoma	2D40	Approved	[279]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[280]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[281]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]

Drug(s) Affected By Glycogenin-2 (GYG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[151]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[117]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[87]

Drug(s) Affected By Fatty acid-binding protein, brain (FABP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[282]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[283]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[284]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[79]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[101]

Drug(s) Affected By Leucine-rich repeat transmembrane protein FLRT2 (FLRT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[285]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[286]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[243]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[275]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[232]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[101]

Drug(s) Affected By SLIT-ROBO Rho GTPase-activating protein 3 (SRGAP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[287]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[288]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[289]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[288]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[287]

Drug(s) Affected By Homeobox protein Hox-A2 (HOXA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[290]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[291]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[228]

Drug(s) Affected By Mothers against decapentaplegic homolog 6 (SMAD6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[292]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[293]

Drug(s) Affected By Carbonic anhydrase 12 (CA12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetazolamide	DM1AF5U	Absence epilepsy		Approved	[294]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[295]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[241]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[295]
Topiramate	DM82Z30	Alcohol dependence	6C40.2	Approved	[296]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[297]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]

Drug(s) Affected By Zinc finger protein SNAI2 (SNAI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[298]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[299]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[300]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]

Drug(s) Affected By Transcription factor 21 (TCF21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[153]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[271]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[110]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[228]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[301]

Drug(s) Affected By ER lumen protein-retaining receptor 3 (KDELR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[197]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[273]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[302]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[302]

Drug(s) Affected By Adhesion G protein-coupled receptor B3 (ADGRB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[118]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[228]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[109]
Lithium chloride	DMHYLQ2	Discovery agent	N.A.	Investigative	[303]

Drug(s) Affected By Protocadherin-7 (PCDH7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[304]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[216]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[305]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[185]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[79]

Drug(s) Affected By Suppression of tumorigenicity 18 protein (ST18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[306]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[228]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[301]

Drug(s) Affected By TBC1 domain family member 4 (TBC1D4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[126]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[85]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[272]

Drug(s) Affected By Protein-tyrosine sulfotransferase 1 (TPST1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[307]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[87]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[118]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[152]

Drug(s) Affected By Clathrin coat assembly protein AP180 (SNAP91)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[109]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[302]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[109]

Drug(s) Affected By Kelch-like protein 41 (KLHL41)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[79]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[87]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[109]

Drug(s) Affected By Perilipin-3 (PLIN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[302]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[302]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[226]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[272]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[87]

Drug(s) Affected By P antigen family member 4 (PAGE4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[285]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[101]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[79]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]

Drug(s) Affected By Receptor activity-modifying protein 1 (RAMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[153]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[149]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[95]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]

Drug(s) Affected By Phosphatase and actin regulator 2 (PHACTR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[183]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[226]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[101]

Drug(s) Affected By Leucine-rich repeat neuronal protein 2 (LRRN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[151]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[117]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[306]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[308]

Drug(s) Affected By Cartilage-associated protein (CRTAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[309]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[126]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[310]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]

Drug(s) Affected By Breast cancer anti-estrogen resistance protein 3 (BCAR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[135]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[311]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[165]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[165]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[239]

Drug(s) Affected By Matrix metalloproteinase-23 (MMP23B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[312]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]

Drug(s) Affected By Regulator of G-protein signaling 20 (RGS20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[228]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[126]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[302]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[302]

Drug(s) Affected By Lymphocyte antigen 6H (LY6H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]

Drug(s) Affected By Slit homolog 2 protein (SLIT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[228]
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[231]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]

Drug(s) Affected By Sorbin and SH3 domain-containing protein 2 (SORBS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[166]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[226]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[146]

Drug(s) Affected By Glutaminase kidney isoform, mitochondrial (GLS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[313]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[314]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[315]

Drug(s) Affected By SLIT and NTRK-like protein 3 (SLITRK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[216]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]

Drug(s) Affected By Myelin protein zero-like protein 1 (MPZL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[88]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[285]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[182]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[182]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[182]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]

Drug(s) Affected By BAG family molecular chaperone regulator 3 (BAG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[187]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[314]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[316]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[314]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[317]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[318]

Drug(s) Affected By EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[319]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[320]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[302]

Drug(s) Affected By Heart- and neural crest derivatives-expressed protein 1 (HAND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[321]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[79]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[301]

Drug(s) Affected By G1/S-specific cyclin-E2 (CCNE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[175]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[89]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[182]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[322]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[323]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[324]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[325]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[165]

Drug(s) Affected By Cytochrome b5 (CYB5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[326]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]

Drug(s) Affected By Tissue-type plasminogen activator (PLAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[327]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[328]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[329]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[330]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[331]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[332]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[333]
Fructose	DM43AN2	Vomiting	MD90	Approved	[334]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[335]

Drug(s) Affected By Serine protease inhibitor Kazal-type 1 (SPINK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[172]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[336]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[241]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[337]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]

Drug(s) Affected By Metalloproteinase inhibitor 1 (TIMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pentoxifylline	DMU3DNC	Alcoholic hepatitis	DB94.1	Approved	[338]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[339]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[340]
Selenium	DM25CGV	N. A.	N. A.	Approved	[341]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[340]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[342]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[343]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[344]

Drug(s) Affected By Pro-neuropeptide Y (NPY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[338]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[338]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[345]
Guanethidine	DM9NSWT	Moderate and severe hypertension	BA00.Z	Approved	[346]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[347]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[348]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[349]

Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[338]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[350]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[351]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[187]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[352]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[242]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[353]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[354]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[355]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[356]

Drug(s) Affected By Collagen alpha-1(III) chain (COL3A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[350]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[357]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[358]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[359]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[360]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[361]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[362]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[363]

Drug(s) Affected By Alpha-crystallin B chain (CRYAB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[229]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[300]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[326]

Drug(s) Affected By Metallothionein-2 (MT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[364]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[160]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[365]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[366]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[314]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[220]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[124]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[165]

Drug(s) Affected By Metallothionein-1A (MT1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[364]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[367]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[368]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[369]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[367]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[367]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]

Drug(s) Affected By Metallothionein-1E (MT1E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[158]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[314]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[368]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[370]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[371]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[372]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[373]

Drug(s) Affected By Sodium/potassium-transporting ATPase subunit beta-1 (ATP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[374]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[375]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[148]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[376]

Drug(s) Affected By Keratin, type II cytoskeletal 8 (KRT8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[187]
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[377]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[378]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[187]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[267]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[379]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]

Drug(s) Affected By Collagen alpha-2(V) chain (COL5A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[172]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[380]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[112]

Drug(s) Affected By Tyrosine-protein kinase Fyn (FYN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[381]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[149]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[382]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[241]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[383]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[239]

Drug(s) Affected By Tyrosine 3-monooxygenase (TH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zonisamide	DM0DTF7	Alcohol dependence	6C40.2	Approved	[384]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[385]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[345]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[386]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[285]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[282]
Methamphetamine	DMPM4SK	Anxiety		Approved	[387]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[388]

Drug(s) Affected By Annexin A2 (ANXA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[389]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[390]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[391]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[392]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[393]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[394]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]

Drug(s) Affected By Calpain-1 catalytic subunit (CAPN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[395]
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[396]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[397]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[398]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[300]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[399]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[400]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]

Drug(s) Affected By Decorin (DCN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[401]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[402]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[230]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[403]

Drug(s) Affected By Procathepsin L (CTSL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[149]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[404]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[405]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[166]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[406]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[404]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]

Drug(s) Affected By Tyrosine-protein kinase Lyn (LYN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[228]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[135]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[407]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]

Drug(s) Affected By Thrombospondin-1 (THBS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[408]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[327]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[153]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[409]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[410]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[335]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[207]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[335]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[135]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[197]

Drug(s) Affected By Collagen alpha-2(I) chain (COL1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[363]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[411]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]

Drug(s) Affected By Annexin A6 (ANXA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[310]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[310]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[141]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]

Drug(s) Affected By Rho-related GTP-binding protein RhoC (RHOC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[412]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[413]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[414]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[415]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]

Drug(s) Affected By Matrix Gla protein (MGP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[416]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[241]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Phytonadione	DM8HDOL	Bleeding disorder	GA20-GA21	Approved	[417]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[250]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[243]

Drug(s) Affected By Keratin, type I cytoskeletal 19 (KRT19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[187]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[327]
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[335]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[335]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[172]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[165]

Drug(s) Affected By SPARC (SPARC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[149]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[315]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[315]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[418]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[419]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[140]

Drug(s) Affected By Platelet-derived growth factor receptor beta (PDGFRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[129]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[420]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[231]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[273]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[250]

Drug(s) Affected By Homeobox protein Hox-C6 (HOXC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[117]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[421]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[422]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[126]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[423]

Drug(s) Affected By Pro-cathepsin H (CTSH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[416]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[213]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[149]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[375]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[319]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[424]

Drug(s) Affected By Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[207]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[172]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[425]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[362]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[426]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]

Drug(s) Affected By Thymosin beta-15A (TMSB15A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[139]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[231]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[427]

Drug(s) Affected By Ras-related protein R-Ras (RRAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[331]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[313]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]

Drug(s) Affected By Tissue factor pathway inhibitor (TFPI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[295]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[295]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[428]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[126]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[281]

Drug(s) Affected By Growth hormone receptor (GHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Bortezomib	DMNO38U	Leukemia		Approved	[429]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[226]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[430]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[228]

Drug(s) Affected By Hyaluronan and proteoglycan link protein 1 (HAPLN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[275]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[293]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[79]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[79]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[233]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]

Drug(s) Affected By Microtubule-associated protein 2 (MAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[431]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[432]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[213]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[433]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[434]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[310]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[435]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[431]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[435]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]

Drug(s) Affected By Collagen alpha-2(VI) chain (COL6A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[228]
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[326]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[273]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[140]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]

Drug(s) Affected By Collagen alpha-3(VI) chain (COL6A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[278]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[230]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[436]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[183]

Drug(s) Affected By Creatine kinase B-type (CKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[408]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[335]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[335]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[437]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[438]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]

Drug(s) Affected By Bone morphogenetic protein 4 (BMP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[408]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[439]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[256]

Drug(s) Affected By Myosin light chain 4 (MYL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[440]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[216]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[284]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[101]

Drug(s) Affected By Cytochrome b-245 light chain (CYBA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[441]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[442]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[443]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[444]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]

Drug(s) Affected By Elongation factor 2 (EEF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[445]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[379]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[446]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[447]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[448]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[448]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[87]

Drug(s) Affected By Annexin A8 (ANXA8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[197]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[243]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[199]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[449]
Benzylpenicillin	DMS9503	Actinomycosis		Phase 3	[284]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[233]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]

Drug(s) Affected By Beta-enolase (ENO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[128]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[310]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[450]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[302]

Drug(s) Affected By Ezrin (EZR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[310]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[331]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[220]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[451]
Haloperidol	DM96SE0	Delirium		Approved	[310]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]

Drug(s) Affected By N-chimaerin (CHN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[452]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[87]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[228]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[453]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[109]

Drug(s) Affected By CD44 antigen (CD44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[138]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[295]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Selenium	DM25CGV	N. A.	N. A.	Approved	[454]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[299]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[455]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[456]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[457]

Drug(s) Affected By Histone H1.2 (H1-2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[249]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[165]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[165]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[126]

Drug(s) Affected By Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 (GNB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[458]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[231]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[326]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
Nortriptyline	DM4KDYJ	Depression	6A70-6A7Z	Approved	[459]
Sibutramine	DMFJTDI	Obesity	5B81	Approved	[460]
Almogran	DM7I64Z	Migraine	8A80	Approved	[461]
Eletriptan	DMW649X	Migraine	8A80	Approved	[461]

Drug(s) Affected By Natriuretic peptides B (NPPB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[358]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[462]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[463]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[464]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[465]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[466]

Drug(s) Affected By Homeobox protein Hox-B8 (HOXB8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[280]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[262]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
EPZ-004777	DMLN4V5	leukaemia	2A60-2B33	Investigative	[467]

Drug(s) Affected By Homeobox protein Hox-B4 (HOXB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]

Drug(s) Affected By Homeobox protein Hox-B6 (HOXB6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[187]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[397]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[216]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[200]

Drug(s) Affected By Neuromodulin (GAP43)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[340]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[340]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[345]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[340]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[386]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Megestrol	DMDH9KX	Breast cancer	2C60-2C65	Approved	[340]

Drug(s) Affected By Insulin-like growth factor-binding protein 3 (IGFBP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[228]
Selenium	DM25CGV	N. A.	N. A.	Approved	[468]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[242]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[469]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[335]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[193]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[470]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[471]

Drug(s) Affected By Integrin beta-5 (ITGB5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[425]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[425]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[425]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[425]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[158]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[160]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[217]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[287]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[409]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[365]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[241]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[314]

Drug(s) Affected By Protachykinin-1 (TAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[472]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[401]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[473]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[474]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Nizatidine	DMGFV3Z	Acid-reflux disorder	DA22	Approved	[472]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[475]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[319]

Drug(s) Affected By Homeobox protein Hox-A5 (HOXA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[476]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[117]

Drug(s) Affected By Ephrin-A1 (EFNA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[477]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[295]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]

Drug(s) Affected By Collagen alpha-1(IX) chain (COL9A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[478]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[271]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[101]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[79]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[262]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]

Drug(s) Affected By Collagen alpha-1(V) chain (COL5A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[411]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[369]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[112]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[479]

Drug(s) Affected By Cannabinoid receptor 1 (CNR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[138]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[480]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[317]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[481]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[482]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]

Drug(s) Affected By Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[483]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[190]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[483]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[484]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[485]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[486]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[483]

Drug(s) Affected By Midkine (MDK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[280]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[487]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[286]

Drug(s) Affected By Bone morphogenetic protein 5 (BMP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[275]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[79]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[488]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[488]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[79]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[79]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]

Drug(s) Affected By Cadherin-3 (CDH3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[489]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[197]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[489]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[311]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[336]

Drug(s) Affected By Calretinin (CALB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[172]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[311]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[490]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[491]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[478]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[271]

Drug(s) Affected By Fibulin-1 (FBLN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[228]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[207]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[207]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[492]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase zeta (PTPRZ1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[319]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[101]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[262]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[228]

Drug(s) Affected By Insulin-like growth factor-binding protein 5 (IGFBP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[408]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[160]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[493]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[470]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[139]

Drug(s) Affected By Paired box protein Pax-6 (PAX6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[494]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[494]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[495]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[494]
Ramelteon	DM7IW9J	Insomnia	7A00-7A0Z	Approved	[494]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[496]
Dabigatran	DMDI6R4	Stroke	8B20	Approved	[494]

Drug(s) Affected By Protein S100-A4 (S100A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[431]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[437]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[497]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[173]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]

Drug(s) Affected By Ciliary neurotrophic factor receptor subunit alpha (CNTFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[302]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[302]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[498]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[308]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[499]

Drug(s) Affected By Stomatin (STOM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[313]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[229]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[313]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[313]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[243]

Drug(s) Affected By Protein-lysine 6-oxidase (LOX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[327]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[500]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[139]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[74]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]

Drug(s) Affected By Homeobox protein MSX-1 (MSX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[501]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[280]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[383]

Drug(s) Affected By Grancalcin (GCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[166]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[199]

Drug(s) Affected By Cellular retinoic acid-binding protein 1 (CRABP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[431]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[302]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[302]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[502]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[430]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[271]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[503]

Drug(s) Affected By Aquaporin-1 (AQP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[138]
Acetazolamide	DM1AF5U	Absence epilepsy		Approved	[504]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[230]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[505]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[506]

Drug(s) Affected By G1/S-specific cyclin-D3 (CCND3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[175]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[507]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[322]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[508]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[509]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[510]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[511]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[451]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[197]

Drug(s) Affected By Tyrosine-protein kinase receptor UFO (AXL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[313]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[409]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[313]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[512]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[165]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[165]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[165]

Drug(s) Affected By Translocator protein (TSPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[338]
Alprazolam	DMC7XDN	Anxiety		Approved	[338]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[431]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[317]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[302]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[302]

Drug(s) Affected By Gastrin-releasing peptide receptor (GRPR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[513]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[233]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[246]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]

Drug(s) Affected By Homeobox protein Hox-C8 (HOXC8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[117]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[118]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[514]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[308]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[515]

Drug(s) Affected By Syndecan-4 (SDC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[516]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[223]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[375]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[135]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[321]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[268]

Drug(s) Affected By Dimethylaniline monooxygenase 4 (FMO4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[226]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[306]

Drug(s) Affected By Gastrin/cholecystokinin type B receptor (CCKBR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[517]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[518]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[79]
Paricalcitol	DMYBV3G	Hyperparathyroidism	5A51	Approved	[338]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[79]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[79]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[518]

Drug(s) Affected By Serpin B6 (SERPINB6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[87]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[79]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[177]

Drug(s) Affected By Apelin receptor (APLNR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[273]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[302]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[302]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[271]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[312]

Drug(s) Affected By Copper-transporting ATPase 2 (ATP7B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[519]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[520]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[231]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]

Drug(s) Affected By Collagen alpha-1(XVIII) chain (COL18A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[228]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[521]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]

Drug(s) Affected By Melanocyte protein PMEL (PMEL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[522]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Vemurafenib	DM62UG5	Melanoma	2C30	Approved	[523]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[302]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[117]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]

Drug(s) Affected By Peripherin (PRPH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[302]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[302]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[524]

Drug(s) Affected By Transcription factor SOX-3 (SOX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[430]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[525]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[79]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]

Drug(s) Affected By Glutamate receptor 2 (GRIA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[526]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[230]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[527]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[110]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[528]
UNC0379	DMD1E4J	Hepatocellular carcinoma	2C12.02	Preclinical	[529]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[228]

Drug(s) Affected By Troponin T, cardiac muscle (TNNT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[530]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[231]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Tacrolimus	DMZ7XNQ	Graft-versus-host disease	4B24	Approved	[531]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[532]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase C (PPIC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[383]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[302]

Drug(s) Affected By Leptin receptor (LEPR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[533]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[534]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[535]
Ketamine	DMT5HA4	Anaesthesia	9A78.6	Approved	[536]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[453]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]

Drug(s) Affected By Neuromedin-U (NMU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[231]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[319]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[453]

Drug(s) Affected By Nestin (NES)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[501]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[537]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[282]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[220]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[310]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]

Drug(s) Affected By Casein kinase I isoform delta (CSNK1D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[226]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[87]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[110]

Drug(s) Affected By CCAAT/enhancer-binding protein delta (CEBPD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[228]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[213]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[145]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]

Drug(s) Affected By Regulator of G-protein signaling 4 (RGS4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[153]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[207]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[197]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[250]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[207]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[207]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1C (CDKN1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[409]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[322]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[335]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[335]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[172]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[84]

Drug(s) Affected By Serpin B9 (SERPINB9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[169]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[335]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[335]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[538]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[172]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]

Drug(s) Affected By Serpin H1 (SERPINH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[153]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[539]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[540]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]

Drug(s) Affected By Ras association domain-containing protein 2 (RASSF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[250]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[541]
Indomethacin	DMSC4A7	Bursitis		Approved	[284]

Drug(s) Affected By Lipopolysaccharide-responsive and beige-like anchor protein (LRBA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[228]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[226]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[542]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]

Drug(s) Affected By RNA-binding protein Nova-1 (NOVA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[285]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[151]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[543]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[79]

Drug(s) Affected By Neuronal membrane glycoprotein M6-a (GPM6A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[375]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[544]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[79]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[545]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[546]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[109]

Drug(s) Affected By Lumican (LUM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[285]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[250]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[547]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[281]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[231]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[376]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[421]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[87]

Drug(s) Affected By Rho GDP-dissociation inhibitor 2 (ARHGDIB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[153]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[313]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[548]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[313]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[273]

Drug(s) Affected By Cationic amino acid transporter 2 (SLC7A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[213]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[76]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[226]

Drug(s) Affected By Atrophin-1 (ATN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[549]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[321]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[276]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[177]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[88]
UNC0379	DMD1E4J	Hepatocellular carcinoma	2C12.02	Preclinical	[529]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[88]

Drug(s) Affected By Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (PDE1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[321]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[479]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[117]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[550]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[228]

Drug(s) Affected By Hydroxymethylglutaryl-CoA synthase, mitochondrial (HMGCS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[425]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[551]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[241]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[283]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[243]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[146]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[552]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[87]

Drug(s) Affected By Phospholipid transfer protein (PLTP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[242]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[235]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]

Drug(s) Affected By Microfibril-associated glycoprotein 4 (MFAP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[153]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[250]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[553]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[478]

Drug(s) Affected By Cadherin-11 (CDH11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[169]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[411]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[285]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[273]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[140]

Drug(s) Affected By Claudin-15 (CLDN15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[554]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[555]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[246]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[228]

Drug(s) Affected By Junctional adhesion molecule B (JAM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[501]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[540]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[289]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[251]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[118]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]

Drug(s) Affected By Myelin proteolipid protein (PLP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[109]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[281]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[544]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[251]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[251]

Drug(s) Affected By Protein S100-A10 (S100A10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[556]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[173]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[263]

Drug(s) Affected By Heart- and neural crest derivatives-expressed protein 2 (HAND2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[132]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[284]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[557]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[306]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[228]

Drug(s) Affected By Neurocalcin-delta (NCALD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[243]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[117]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[79]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[79]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[79]

Drug(s) Affected By cAMP-dependent protein kinase inhibitor alpha (PKIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[172]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[311]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Bortezomib	DMNO38U	Leukemia		Approved	[84]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[243]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]

Drug(s) Affected By Actin, alpha cardiac muscle 1 (ACTC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[132]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[250]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[558]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Methamphetamine	DMPM4SK	Anxiety		Approved	[559]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[558]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[293]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]

Drug(s) Affected By Actin, alpha skeletal muscle (ACTA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[228]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[231]

Drug(s) Affected By Pituitary homeobox 1 (PITX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[293]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[106]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[251]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]

Drug(s) Affected By Oxidized low-density lipoprotein receptor 1 (OLR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[187]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[187]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[235]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[560]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[561]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[369]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[187]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[187]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[562]

Drug(s) Affected By Iroquois-class homeodomain protein IRX-5 (IRX5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[95]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[101]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[79]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[107]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]

Drug(s) Affected By Reelin (RELN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[228]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[563]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[320]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]

Drug(s) Affected By Arginase-2, mitochondrial (ARG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[172]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[564]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[565]

Drug(s) Affected By Metallothionein-1X (MT1X)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[158]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[566]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[314]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[220]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]

Drug(s) Affected By Matrix-remodeling-associated protein 7 (MXRA7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[485]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]

Drug(s) Affected By Disabled homolog 2 (DAB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[280]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[220]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[567]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[139]

Drug(s) Affected By Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (PDE1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[317]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[228]

Drug(s) Affected By Myosin regulatory light chain 2, atrial isoform (MYL7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[264]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[568]
Ximelegatran	DMU8ANS	Myocardial infarction	BA41-BA43	Approved	[569]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Phenylephrine	DMZHUO5	Allergic rhinitis	CA08.0	Approved	[569]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[101]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]

Drug(s) Affected By Peripheral myelin protein 22 (PMP22)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[109]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[570]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[571]

Drug(s) Affected By Flavin-containing monooxygenase 1 (FMO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[191]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[162]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[572]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Dihydroxyacetone	DMM1LG2	Sunburn	EJ40	Approved	[573]
Atazanavir	DMSYRBX	Human immunodeficiency virus infection	1C62	Approved	[572]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[574]

Drug(s) Affected By ATP-dependent 6-phosphofructokinase, platelet type (PFKP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[228]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[410]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[267]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[278]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[117]

Drug(s) Affected By Zinc finger protein basonuclin-1 (BNC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[228]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[197]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[575]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[479]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[272]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[576]

Drug(s) Affected By Transgelin (TAGLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[577]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[327]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[578]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[577]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[263]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[577]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[577]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[579]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[578]

Drug(s) Affected By Guanylate cyclase soluble subunit alpha-1 (GUCY1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[580]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[231]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[117]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[581]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[270]

Drug(s) Affected By Sterol 26-hydroxylase, mitochondrial (CYP27A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[582]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[583]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[128]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[335]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[584]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[585]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[586]

Drug(s) Affected By Desmocollin-2 (DSC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[231]

Drug(s) Affected By Angiopoietin-1 receptor (TEK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[587]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[587]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[588]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[521]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[285]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[589]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[590]

Drug(s) Affected By Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (PLOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[151]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[591]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]

Drug(s) Affected By Transforming growth factor beta receptor type 3 (TGFBR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[351]
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[172]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[592]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[273]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]

Drug(s) Affected By Parathyroid hormone/parathyroid hormone-related peptide receptor (PTH1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]
Paricalcitol	DMYBV3G	Hyperparathyroidism	5A51	Approved	[338]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[197]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[117]
Acetazolamide	DM1AF5U	Absence epilepsy		Approved	[338]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[338]
Furosemide	DMMQ8ZG	Congestive heart failure	BD10	Approved	[338]

Drug(s) Affected By MBT domain-containing protein 1 (MBTD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[489]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[226]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[593]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]

Drug(s) Affected By 3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[375]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[172]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[594]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[126]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[273]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[141]

Drug(s) Affected By Trefoil factor 3 (TFF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[595]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[596]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[95]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[498]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[595]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[272]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[272]

Drug(s) Affected By Regulator of G-protein signaling 1 (RGS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[153]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[169]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[126]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[104]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[597]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[598]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[141]

Drug(s) Affected By Neuroblast differentiation-associated protein AHNAK (AHNAK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[416]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[88]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[126]

Drug(s) Affected By Coiled-coil domain-containing protein 15 (CCDC15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[321]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[166]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]

Drug(s) Affected By Transmembrane protein 62 (TMEM62)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[228]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[151]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[599]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[244]

Drug(s) Affected By Bone marrow stromal antigen 2 (BST2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[207]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[207]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[172]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[600]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[207]

Drug(s) Affected By CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1 (ST3GAL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[430]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[199]

Drug(s) Affected By Tyrosine-protein kinase Mer (MERTK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[241]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[302]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[243]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[601]

Drug(s) Affected By Transmembrane emp24 domain-containing protein 1 (TMED1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[602]

Drug(s) Affected By Filamin-C (FLNC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[228]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[313]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[313]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[313]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[151]

Drug(s) Affected By Transforming growth factor beta activator LRRC32 (LRRC32)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[603]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[604]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[308]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[144]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[137]

Drug(s) Affected By Phosphatidylinositol N-acetylglucosaminyltransferase subunit H (PIGH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[101]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[87]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[110]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[228]

Drug(s) Affected By Desmocollin-3 (DSC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[605]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[272]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[606]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[109]

Drug(s) Affected By Eukaryotic translation initiation factor 4H (EIF4H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[607]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[88]
D-glucose	DMMG2TO	Discovery agent	N.A.	Investigative	[608]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[608]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[609]

Drug(s) Affected By Periostin (POSTN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[489]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[140]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[565]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[226]

Drug(s) Affected By Phosphoglucomutase-like protein 5 (PGM5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[229]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[243]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[117]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[610]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[109]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[423]

Drug(s) Affected By Nicotinate-nucleotide pyrophosphorylase (QPRT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[229]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[561]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[243]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[117]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[611]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[87]

Drug(s) Affected By Leucine-rich repeat-containing protein 41 (LRRC41)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Bortezomib	DMNO38U	Leukemia		Approved	[84]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[110]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[246]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[88]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[109]

Drug(s) Affected By Delta(24)-sterol reductase (DHCR24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[612]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[522]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[613]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]

Drug(s) Affected By Probable G-protein coupled receptor 19 (GPR19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[118]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
QUERCITRIN	DM1DH96	Discovery agent	N.A.	Investigative	[614]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[126]

Drug(s) Affected By Alpha-internexin (INA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[431]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[615]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[233]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[615]

Drug(s) Affected By Kynureninase (KYNU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[295]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[249]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[170]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[295]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[375]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[126]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]

Drug(s) Affected By Thiosulfate sulfurtransferase (TST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[95]

Drug(s) Affected By Reticulon-1 (RTN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[479]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[151]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[79]

Drug(s) Affected By Discoidin domain-containing receptor 2 (DDR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[437]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[616]
Lithium	DMZ3OU6	Bipolar disorder	6A60	Phase 2	[617]

Drug(s) Affected By Rho GTPase-activating protein 44 (ARHGAP44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[311]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[228]
OXYQUINOLINE	DMZVS9Y	Discovery agent	N.A.	Investigative	[74]

Drug(s) Affected By Sodium-coupled monocarboxylate transporter 2 (SLC5A12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[375]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[231]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[478]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[109]

Drug(s) Affected By Keratin, type I cytoskeletal 24 (KRT24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[172]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[152]

Drug(s) Affected By Electroneutral sodium bicarbonate exchanger 1 (SLC4A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[109]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[151]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[618]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[262]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[308]

Drug(s) Affected By HLA class II histocompatibility antigen, DR beta 5 chain (HLA-DRB5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[619]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[620]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[619]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[272]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[621]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[234]

Drug(s) Affected By Probable ubiquitin carboxyl-terminal hydrolase MINDY-4 (MINDY4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[246]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]

Drug(s) Affected By 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 (PLCH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[293]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[251]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[87]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[79]

Drug(s) Affected By Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 (SVEP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[250]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[547]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]

Drug(s) Affected By PDZ and LIM domain protein 3 (PDLIM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[565]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[302]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[302]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[117]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[622]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]

Drug(s) Affected By Protein LBH (LBH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[126]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[241]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[273]

Drug(s) Affected By Cordon-bleu protein-like 1 (COBLL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[375]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[623]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]

Drug(s) Affected By Spindlin-4 (SPIN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[126]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[166]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[453]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]

Drug(s) Affected By Trans-2,3-enoyl-CoA reductase-like (TECRL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]

Drug(s) Affected By Placenta-specific protein 9 (PLAC9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[624]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]

Drug(s) Affected By Collectin-12 (COLEC12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[153]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[489]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[207]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[207]

Drug(s) Affected By CUGBP Elav-like family member 3 (CELF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[117]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]

Drug(s) Affected By KN motif and ankyrin repeat domain-containing protein 4 (KANK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[166]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[302]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[302]

Drug(s) Affected By Transcription factor HES-5 (HES5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[625]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[151]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[553]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[79]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[79]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[79]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]

Drug(s) Affected By Collagen alpha-1(XIII) chain (COL13A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[229]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[259]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[302]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[239]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[151]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]

Drug(s) Affected By Terminal nucleotidyltransferase 5C (TENT5C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[249]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[225]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[126]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[231]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]

Drug(s) Affected By FYN-binding protein 2 (FYB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[311]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[226]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[79]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[87]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[306]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[228]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[109]

Drug(s) Affected By F-actin-uncapping protein LRRC16A (CARMIL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[226]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[338]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[107]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[88]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[88]

Drug(s) Affected By Pikachurin (EGFLAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[79]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[626]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]

Drug(s) Affected By Carboxypeptidase Z (CPZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[285]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[151]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[251]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[627]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[228]

Drug(s) Affected By NADH-cytochrome b5 reductase 2 (CYB5R2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[228]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[170]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[109]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[532]

Drug(s) Affected By Repulsive guidance molecule B (RGMB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[311]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[250]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[181]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]

Drug(s) Affected By Caveolae-associated protein 1 (CAVIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[628]
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[326]

Drug(s) Affected By Cdc42 effector protein 5 (CDC42EP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[302]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[302]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[79]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[262]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[228]

Drug(s) Affected By Cytochrome b5 domain-containing protein 1 (CYB5D1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[228]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[226]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[117]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]

Drug(s) Affected By Transmembrane protein 88 (TMEM88)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[538]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[181]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[289]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[79]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]

Drug(s) Affected By Protein cornichon homolog 2 (CNIH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[137]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[423]

Drug(s) Affected By Prostate androgen-regulated mucin-like protein 1 (PARM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[243]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[185]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]

Drug(s) Affected By Inactive serine protease PAMR1 (PAMR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[228]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[302]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[302]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[243]

Drug(s) Affected By R-spondin-2 (RSPO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[181]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[151]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[79]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[251]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[79]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[109]

Drug(s) Affected By Zinc finger protein basonuclin-2 (BNC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[501]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[181]

Drug(s) Affected By Staphylococcal nuclease domain-containing protein 1 (SND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[107]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[88]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[277]

Drug(s) Affected By Monocarboxylate transporter 9 (SLC16A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[281]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[273]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[117]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[421]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[101]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[629]

Drug(s) Affected By Centriolin (CNTRL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[630]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[524]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[631]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[79]

Drug(s) Affected By Calcium/calmodulin-dependent protein kinase II inhibitor 1 (CAMK2N1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[228]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[319]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[302]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[95]

Drug(s) Affected By Schlafen family member 11 (SLFN11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[250]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[228]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[109]

Drug(s) Affected By Polypeptide N-acetylgalactosaminyltransferase 10 (GALNT10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[148]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[624]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]

Drug(s) Affected By Alpha-protein kinase 2 (ALPK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[126]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[241]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[270]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]

Drug(s) Affected By E3 ubiquitin-protein ligase MARCHF3 (MARCHF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[172]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[250]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[243]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[251]

Drug(s) Affected By Transmembrane protein 200A (TMEM200A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[172]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[181]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[239]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[87]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[228]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[126]

Drug(s) Affected By Podoplanin (PDPN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[632]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[79]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[79]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[233]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
PMID26394986-Compound-22	DM43Z1G	N. A.	N. A.	Patented	[633]

Drug(s) Affected By Rhophilin-2 (RHPN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[87]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[79]

Drug(s) Affected By Epidermal growth factor-like protein 6 (EGFL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[230]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[216]
Indomethacin	DMSC4A7	Bursitis		Approved	[284]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[79]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[634]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[634]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[634]

Drug(s) Affected By 5'-3' exonuclease PLD3 (PLD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[323]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[203]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[635]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]

Drug(s) Affected By Neuron navigator 2 (NAV2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[636]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[197]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]

Drug(s) Affected By Somatomedin-B and thrombospondin type-1 domain-containing protein (SBSPON)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[637]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[249]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[228]

Drug(s) Affected By N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase (GCNT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Bortezomib	DMNO38U	Leukemia		Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[183]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[226]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]

Drug(s) Affected By Sperm-associated antigen 16 protein (SPAG16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[199]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[100]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[638]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]

Drug(s) Affected By Cytochrome P450 4X1 (CYP4X1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[639]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[231]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[241]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[243]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[146]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[101]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[79]

Drug(s) Affected By Inactive serine protease 35 (PRSS35)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[197]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[547]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[109]

Drug(s) Affected By Secreted frizzled-related protein 1 (SFRP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[169]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[640]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[172]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[139]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[419]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[317]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[285]

Drug(s) Affected By Reprimo-like protein (RPRML)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[151]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[79]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[514]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[109]

Drug(s) Affected By Actin filament-associated protein 1-like 2 (AFAP1L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[229]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[302]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[302]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[117]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[641]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[228]

Drug(s) Affected By Protocadherin-20 (PCDH20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[273]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]

Drug(s) Affected By Fibrous sheath-interacting protein 1 (FSIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[172]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[642]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[643]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[547]

Drug(s) Affected By Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 (ST6GALNAC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[101]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]

Drug(s) Affected By Trinucleotide repeat-containing gene 6A protein (TNRC6A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[153]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[216]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[226]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[246]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[88]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[576]
Manganese	DMKT129	N. A.	N. A.	Investigative	[644]

Drug(s) Affected By Coiled-coil domain-containing protein 112 (CCDC112)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[623]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[87]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]

Drug(s) Affected By Class E basic helix-loop-helix protein 22 (BHLHE22)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[228]

Drug(s) Affected By Secretory carrier-associated membrane protein 5 (SCAMP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[375]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[488]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[488]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[87]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]

Drug(s) Affected By Protein odd-skipped-related 1 (OSR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[135]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[645]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[87]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]

Drug(s) Affected By DEP domain-containing mTOR-interacting protein (DEPTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[228]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[646]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[250]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]

Drug(s) Affected By Protein MGARP (MGARP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[126]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[79]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]

Drug(s) Affected By Mucolipin-3 (MCOLN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[243]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[478]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[79]

Drug(s) Affected By Breast carcinoma-amplified sequence 4 (BCAS4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[243]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[101]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[272]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[272]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[246]

Drug(s) Affected By E3 ubiquitin-protein ligase SH3RF2 (SH3RF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[172]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[630]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[239]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[117]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[553]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]

Drug(s) Affected By Docking protein 4 (DOK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[320]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[647]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[320]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[320]

Drug(s) Affected By Probable phospholipid-transporting ATPase IM (ATP8B4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[79]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[87]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[228]

Drug(s) Affected By Cell migration-inducing and hyaluronan-binding protein (CEMIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[172]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[239]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[151]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[601]

Drug(s) Affected By Leucine-rich repeat neuronal protein 4 (LRRN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[564]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[87]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[262]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[109]

Drug(s) Affected By Selenoprotein M (SELENOM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[217]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[645]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[648]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]

Drug(s) Affected By Atlastin-1 (ATL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[203]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[79]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[109]

Drug(s) Affected By E3 ubiquitin-protein ligase MYLIP (MYLIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[172]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[226]

Drug(s) Affected By Cyclic GMP-AMP phosphodiesterase SMPDL3A (SMPDL3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[95]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[645]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[151]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[185]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[349]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[272]

Drug(s) Affected By SEC14-like protein 1 (SEC14L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[319]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[649]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[272]

Drug(s) Affected By Protein NDRG1 (NDRG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[401]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[650]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[651]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[410]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[213]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[273]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]

Drug(s) Affected By Ankyrin repeat and SAM domain-containing protein 1A (ANKS1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[431]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[151]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[117]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[107]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[88]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[88]

Drug(s) Affected By Serine protease HTRA1 (HTRA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[498]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Tirbanibulin	DMJNV4O	Actinic keratosis	EK90.0	Approved	[498]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[250]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[498]

Drug(s) Affected By Secreted frizzled-related protein 3 (FRZB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[489]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[489]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[311]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[231]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[273]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]

Drug(s) Affected By Hyaluronan synthase 2 (HAS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[300]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[250]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[652]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[653]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]

Drug(s) Affected By Proprotein convertase subtilisin/kexin type 5 (PCSK5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[375]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[87]

Drug(s) Affected By Kallikrein-6 (KLK6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[172]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[426]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[302]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[302]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[502]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[430]

Drug(s) Affected By Exostosin-2 (EXT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[151]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[275]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[101]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[228]

Drug(s) Affected By Ecto-ADP-ribosyltransferase 4 (ART4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[226]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[146]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[87]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[654]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[655]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[656]

Drug(s) Affected By Caveolae-associated protein 3 (CAVIN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[217]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[267]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[101]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[272]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[110]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[146]

Drug(s) Affected By Myeloid-derived growth factor (MYDGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[648]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[270]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[277]

Drug(s) Affected By Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 (ST6GALNAC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[657]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[658]

Drug(s) Affected By Coiled-coil domain-containing protein 102A (CCDC102A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[291]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[88]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[423]

Drug(s) Affected By Ras-related and estrogen-regulated growth inhibitor (RERG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[453]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[659]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[262]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]

Drug(s) Affected By Ras-related protein Rab-37 (RAB37)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[243]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[117]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[79]

Drug(s) Affected By Store-operated calcium entry-associated regulatory factor (SARAF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[151]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[87]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[593]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[180]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[515]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[609]

Drug(s) Affected By BTB/POZ domain-containing protein KCTD12 (KCTD12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[375]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[466]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[310]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[310]

Drug(s) Affected By Multivesicular body subunit 12A (MVB12A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[177]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]

Drug(s) Affected By E3 ubiquitin-protein ligase pellino homolog 1 (PELI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[660]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[660]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[660]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[661]

Drug(s) Affected By Phytanoyl-CoA hydroxylase-interacting protein-like (PHYHIPL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[87]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[656]

Drug(s) Affected By Multidrug and toxin extrusion protein 1 (SLC47A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pyrimethamine	DM5X7VY	Malaria	1F40-1F45	Approved	[662]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[663]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[664]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[663]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[153]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[663]

Drug(s) Affected By Vacuolar-sorting protein SNF8 (SNF8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[661]

Drug(s) Affected By Secreted frizzled-related protein 2 (SFRP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[665]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[284]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]

Drug(s) Affected By PC-esterase domain-containing protein 1B (PCED1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[229]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[117]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[87]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[233]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[228]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[126]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[423]

Drug(s) Affected By Terminal nucleotidyltransferase 5A (TENT5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[249]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[213]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[273]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]

Drug(s) Affected By Leucine-rich repeats and immunoglobulin-like domains protein 1 (LRIG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[95]

Drug(s) Affected By Lysyl oxidase homolog 4 (LOXL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[666]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[293]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[641]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[667]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[87]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]

Drug(s) Affected By Multiple epidermal growth factor-like domains protein 10 (MEGF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[101]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[79]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[262]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[109]

Drug(s) Affected By N-terminal kinase-like protein (SCYL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[668]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[246]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[669]

Drug(s) Affected By Ecto-ADP-ribosyltransferase 5 (ART5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[101]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[262]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]

Drug(s) Affected By Protein phosphatase 1M (PPM1M)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[177]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[277]

Drug(s) Affected By Roundabout homolog 3 (ROBO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[231]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[313]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]

Drug(s) Affected By Prickle-like protein 1 (PRICKLE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[109]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[239]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[243]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[79]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[312]

Drug(s) Affected By Leucine-rich repeat and fibronectin type-III domain-containing protein 5 (LRFN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[243]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]

Drug(s) Affected By Guanylate-binding protein 4 (GBP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[229]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[126]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[226]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[641]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[253]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[233]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]

Drug(s) Affected By Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (MAGI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[228]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[670]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[671]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]

Drug(s) Affected By Myeloid-associated differentiation marker (MYADM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[158]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[126]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[95]

Drug(s) Affected By Protein Niban 2 (NIBAN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[320]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[88]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[228]

Drug(s) Affected By Transcription factor 12 (TCF12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[153]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[407]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[407]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[304]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[259]

Drug(s) Affected By Protein kinase C-binding protein NELL2 (NELL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[302]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[302]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[79]

Drug(s) Affected By G-protein coupled estrogen receptor 1 (GPER1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[672]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[169]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[485]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[672]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[241]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[673]

Drug(s) Affected By Pituitary homeobox 2 (PITX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[169]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[172]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[95]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[479]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[146]

Drug(s) Affected By Plakophilin-2 (PKP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[169]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[172]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[148]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]

Drug(s) Affected By Cbp/p300-interacting transactivator 2 (CITED2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[408]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[225]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]

Drug(s) Affected By Ribosome quality control complex subunit TCF25 (TCF25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[591]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[591]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[277]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[88]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[591]
geraniol	DMS3CBD	Discovery agent	N.A.	Investigative	[674]

Drug(s) Affected By Allograft inflammatory factor 1-like (AIF1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[217]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[217]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[675]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[87]

Drug(s) Affected By SH3-containing GRB2-like protein 3-interacting protein 1 (SGIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[228]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[311]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[285]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[243]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]

Drug(s) Affected By Transcription elongation factor A protein-like 7 (TCEAL7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[623]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[244]

Drug(s) Affected By Histone H2A.J (H2AJ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[310]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Haloperidol	DM96SE0	Delirium		Approved	[310]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[310]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[310]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[216]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]

Drug(s) Affected By Ribonuclease P protein subunit p25 (RPP25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[624]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[117]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[79]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]

Drug(s) Affected By EF-hand domain-containing protein D1 (EFHD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[231]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[302]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[430]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[641]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[272]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[676]

Drug(s) Affected By Arginine/serine-rich protein 1 (RSRP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[305]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[226]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[117]

Drug(s) Affected By Transmembrane emp24 domain-containing protein 9 (TMED9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[217]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[217]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[270]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[276]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[277]

Drug(s) Affected By Max dimerization protein 3 (MXD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[321]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[624]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[677]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]

Drug(s) Affected By Transcription factor GATA-5 (GATA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[273]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[302]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[302]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[228]

Drug(s) Affected By Oxysterol-binding protein-related protein 10 (OSBPL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[181]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[302]

Drug(s) Affected By Uncharacterized protein KIAA1671 (KIAA1671)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[151]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[87]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[88]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[88]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[308]

Drug(s) Affected By Tripartite motif-containing protein 6 (TRIM6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[229]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[319]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[79]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]

Drug(s) Affected By Tripartite motif-containing protein 5 (TRIM5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[148]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[226]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[117]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[270]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[638]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[228]

Drug(s) Affected By RNA exonuclease 4 (REXO4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[88]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[88]

Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 19 (ADAM19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[259]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[302]

Drug(s) Affected By Cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[172]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[165]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[285]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[250]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[479]

Drug(s) Affected By Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[678]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[165]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[165]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[561]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]

Drug(s) Affected By Small conductance calcium-activated potassium channel protein 2 (KCNN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[679]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[126]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[565]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[622]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[270]

Drug(s) Affected By Thiamin pyrophosphokinase 1 (TPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[228]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[251]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[272]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[100]

Drug(s) Affected By SPARC-related modular calcium-binding protein 2 (SMOC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[95]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[601]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]

Drug(s) Affected By Leucine-rich repeat neuronal protein 3 (LRRN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[79]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[79]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[680]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[79]

Drug(s) Affected By RWD domain-containing protein 1 (RWDD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[126]
AM251	DMTAWHL	Discovery agent	N.A.	Investigative	[681]

Drug(s) Affected By Calcium-binding protein 39-like (CAB39L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[540]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[185]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[87]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[247]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[118]

Drug(s) Affected By Spondin-1 (SPON1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[207]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[207]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[682]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[272]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[272]

Drug(s) Affected By Anoctamin-8 (ANO8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[233]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]

Drug(s) Affected By Synaptotagmin-like protein 2 (SYTL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[228]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[229]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[151]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[490]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[601]

Drug(s) Affected By Solute carrier family 40 member 1 (SLC40A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[76]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[235]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[336]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[683]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]

Drug(s) Affected By Zinc transporter ZIP2 (SLC39A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[639]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[101]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[643]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[110]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[152]

Drug(s) Affected By NADPH oxidase 4 (NOX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[441]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[684]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[685]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[686]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[241]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[687]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[369]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[688]

Drug(s) Affected By Nuclear receptor-interacting protein 3 (NRIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[231]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[624]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[547]

Drug(s) Affected By G-protein coupled receptor family C group 5 member C (GPRC5C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[273]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[216]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]

Drug(s) Affected By PR domain zinc finger protein 8 (PRDM8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[213]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[216]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[262]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[306]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]

Drug(s) Affected By Integral membrane protein 2C (ITM2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[689]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[151]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[87]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[110]

Drug(s) Affected By Rho guanine nucleotide exchange factor 3 (ARHGEF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[670]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[151]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[349]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]

Drug(s) Affected By Olfactomedin-like protein 3 (OLFML3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[281]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[140]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[320]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[112]

Drug(s) Affected By Kinesin-like protein KIF15 (KIF15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[240]

Drug(s) Affected By Serine palmitoyltransferase 3 (SPTLC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[166]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[226]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]

Drug(s) Affected By Transmembrane protein 45A (TMEM45A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[273]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[165]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[479]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[447]

Drug(s) Affected By Host cell factor C1 regulator 1 (HCFC1R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[431]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[302]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[302]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[243]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[117]

Drug(s) Affected By Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase (BPNT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[151]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[117]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[101]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[655]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[228]

Drug(s) Affected By PH and SEC7 domain-containing protein 3 (PSD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[235]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[126]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[148]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[181]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[239]

Drug(s) Affected By G-protein coupled receptor 83 (GPR83)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
QUERCITRIN	DM1DH96	Discovery agent	N.A.	Investigative	[614]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[690]

Drug(s) Affected By Podocalyxin-like protein 2 (PODXL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[312]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[656]

Drug(s) Affected By Ral guanine nucleotide dissociation stimulator-like 1 (RGL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[228]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[287]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[235]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[126]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]

Drug(s) Affected By Myoferlin (MYOF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[235]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[502]

Drug(s) Affected By Low-density lipoprotein receptor-related protein 1B (LRP1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[101]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[244]

Drug(s) Affected By LIM and cysteine-rich domains protein 1 (LMCD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[165]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[165]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[165]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[285]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[250]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]

Drug(s) Affected By Protein PALS2 (PALS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[148]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[302]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[302]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]

Drug(s) Affected By Spermatogenesis-associated protein 7 (SPATA7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[84]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[181]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[302]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[302]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[151]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[185]

Drug(s) Affected By Neurotrimin (NTM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[228]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[691]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[151]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[349]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
PD-0325901	DM27D4J	Breast cancer	2C60-2C65	Phase 2	[692]

Drug(s) Affected By Dynein axonemal heavy chain 2 (DNAH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[284]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[693]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]

Drug(s) Affected By Semaphorin-5B (SEMA5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[694]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[251]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[101]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]

Drug(s) Affected By Signal-induced proliferation-associated 1-like protein 2 (SIPA1L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[165]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[165]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[245]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[165]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]

Drug(s) Affected By Protein dispatched homolog 3 (DISP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[87]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[262]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[690]

Drug(s) Affected By A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[431]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[695]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[320]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[112]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[696]

Drug(s) Affected By Vesicular glutamate transporter 2 (SLC17A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[230]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[132]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[440]

Drug(s) Affected By Beta-1,4-galactosyltransferase 7 (B4GALT7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[101]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[697]

Drug(s) Affected By Tachykinin-3 (TAC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[302]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[302]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[479]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[101]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]

Drug(s) Affected By A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[698]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[220]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[361]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]

Drug(s) Affected By Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAIAP2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Streptozocin	DMOF7AT	Pancreatic cancer	2C10	Approved	[338]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[166]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[216]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[302]

Drug(s) Affected By SERTA domain-containing protein 1 (SERTAD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[197]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[165]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[165]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[165]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[126]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[165]

Drug(s) Affected By F-box only protein 2 (FBXO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[273]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]

Drug(s) Affected By Angiopoietin-related protein 2 (ANGPTL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[250]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[226]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[251]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[87]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[233]

Drug(s) Affected By Microtubule-associated tumor suppressor 1 (MTUS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[172]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[203]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[226]

Drug(s) Affected By Y+L amino acid transporter 1 (SLC7A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[76]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[336]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[699]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[226]

Drug(s) Affected By Lysosomal thioesterase PPT2 (PPT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[700]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[285]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[106]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[228]

Drug(s) Affected By Protein NDRG2 (NDRG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[561]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]

Drug(s) Affected By LIM and calponin homology domains-containing protein 1 (LIMCH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[281]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]

Drug(s) Affected By Type 2 lactosamine alpha-2,3-sialyltransferase (ST3GAL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[228]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[95]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[544]

Drug(s) Affected By Nuclease EXOG, mitochondrial (EXOG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[375]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[126]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[273]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[701]

Drug(s) Affected By Netrin-G1 (NTNG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[277]

Drug(s) Affected By Protein SSUH2 homolog (SSUH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[262]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[79]
OXYQUINOLINE	DMZVS9Y	Discovery agent	N.A.	Investigative	[74]

Drug(s) Affected By Transmembrane protein 98 (TMEM98)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[231]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[100]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[199]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[233]

Drug(s) Affected By Plasmolipin (PLLP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[172]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[117]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]

Drug(s) Affected By C2 domain-containing protein 2 (C2CD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[180]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[226]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[275]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[88]

Drug(s) Affected By Talin-2 (TLN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[310]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[331]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[197]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[592]
Haloperidol	DM96SE0	Delirium		Approved	[310]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[310]

Drug(s) Affected By Protein mab-21-like 2 (MAB21L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[79]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[109]

Drug(s) Affected By Transient receptor potential cation channel subfamily V member 2 (TRPV2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[702]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[703]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Tranilast	DME5Y64	Allergic rhinitis	CA08.0	Approved	[704]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[216]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[547]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]

Drug(s) Affected By Transcription factor SOX-21 (SOX21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[302]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[302]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[696]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[291]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[312]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[705]

Drug(s) Affected By LHFPL tetraspan subfamily member 6 protein (LHFPL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[444]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[239]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[151]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[641]

Drug(s) Affected By Stonin-1 (STON1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[117]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[227]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[253]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]

Drug(s) Affected By Transcription factor E2F8 (E2F8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[144]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[126]

Drug(s) Affected By Thymidine kinase 2, mitochondrial (TK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[76]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[172]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[706]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[670]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[226]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[184]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[182]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[707]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[138]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[186]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[516]
Selenium	DM25CGV	N. A.	N. A.	Approved	[708]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[182]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[709]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[709]

Drug(s) Affected By Protein regulator of cytokinesis 1 (PRC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[408]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[710]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[165]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[165]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]

Drug(s) Affected By PRA1 family protein 3 (ARL6IP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[711]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[135]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[424]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]

Drug(s) Affected By Prothrombin (F2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[712]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[153]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[412]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[223]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[511]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[713]
Phytonadione	DM8HDOL	Bleeding disorder	GA20-GA21	Approved	[714]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[715]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[716]

Drug(s) Affected By Plasminogen (PLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[717]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[718]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[719]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[226]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[146]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[251]

Drug(s) Affected By Prolactin (PRL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[720]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[721]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[722]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[723]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[153]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[724]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[725]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[726]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[727]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[728]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[729]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[730]
Fructose	DM43AN2	Vomiting	MD90	Approved	[338]
Ketoprofen	DMRKXPT	Bursitis		Approved	[338]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[731]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[732]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[733]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[734]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[735]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[401]

Drug(s) Affected By Thymidine kinase, cytosolic (TK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[736]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[737]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[160]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[738]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[128]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[170]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[739]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[740]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]

Drug(s) Affected By Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[741]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[161]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[742]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[438]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[743]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[310]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[207]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[744]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[745]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[746]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[747]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[401]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[748]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[749]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[207]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[750]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[751]
Fructose	DM43AN2	Vomiting	MD90	Approved	[338]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[752]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[753]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[159]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[754]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[249]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[755]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[756]

Drug(s) Affected By High mobility group protein B1 (HMGB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[416]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[757]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[758]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[300]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[759]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[760]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[761]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[762]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[763]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[764]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[763]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[765]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[766]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[767]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[768]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[769]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[770]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[771]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[338]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[772]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[773]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[732]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[774]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[209]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[775]
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[530]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[776]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[777]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[778]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[779]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[780]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[781]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[158]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[159]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[533]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[782]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[217]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[783]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[313]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[195]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[784]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[785]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[187]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[160]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[762]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[786]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[787]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[788]
Fructose	DM43AN2	Vomiting	MD90	Approved	[334]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[187]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[660]

Drug(s) Affected By Cyclin-dependent kinases regulatory subunit 2 (CKS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[511]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[124]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[154]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[324]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[501]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[754]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[789]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[790]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[160]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[791]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[792]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[764]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[182]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[793]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[794]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[795]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[796]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[797]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[798]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[799]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[800]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[801]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[802]

Drug(s) Affected By Importin subunit alpha-1 (KPNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[416]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[431]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[803]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[215]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[804]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[240]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]

Drug(s) Affected By Sestrin-3 (SESN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[805]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[172]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[806]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[285]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]

Drug(s) Affected By Beta-2-microglobulin (B2M)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[807]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[431]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[808]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[548]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[361]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[809]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[810]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[336]

Drug(s) Affected By 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 (PLCB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[117]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[11]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[177]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]
QUERCITRIN	DM1DH96	Discovery agent	N.A.	Investigative	[614]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[138]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[774]
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[651]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[811]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[812]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[813]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[814]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[768]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[802]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[772]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[187]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[815]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[790]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[816]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[764]

Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[732]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[187]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[817]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[190]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[818]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[187]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[819]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[820]

Drug(s) Affected By Cyclin-dependent kinase 5 activator 1 (CDK5R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[395]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[821]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[287]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[287]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[822]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[682]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[117]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[682]

Drug(s) Affected By Borealin (CDCA8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[564]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[240]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[133]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[371]

Drug(s) Affected By Proline/serine-rich coiled-coil protein 1 (PSRC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[325]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[101]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[240]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[84]

Drug(s) Affected By Protein aurora borealis (BORA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[501]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[325]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[240]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[250]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[166]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[710]

Drug(s) Affected By Jouberin (AHI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[823]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[823]
Omacetaxine mepesuccinate	DMPU2WX	Adult acute monocytic leukemia		Approved	[823]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[79]

Drug(s) Affected By Transient receptor potential cation channel subfamily V member 1 (TRPV1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[824]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[825]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[311]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[826]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[475]
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[827]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 19 (TNFRSF19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[138]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[287]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[311]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[287]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[166]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[181]

Drug(s) Affected By Solute carrier family 12 member 6 (SLC12A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[88]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[197]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[828]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[87]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[485]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[629]

Drug(s) Affected By Lactosylceramide alpha-2,3-sialyltransferase (ST3GAL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[287]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[287]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[243]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[233]

Drug(s) Affected By Hairy/enhancer-of-split related with YRPW motif protein 1 (HEY1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[625]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[592]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[319]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[166]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]

Drug(s) Affected By Interleukin-3 (IL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[153]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[829]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[829]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[317]
Betamethasone Valerate	DMMIAXO	Dermatological disease	DA24.Y	Approved	[830]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[831]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Tacrolimus	DMZ7XNQ	Graft-versus-host disease	4B24	Approved	[830]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[338]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[338]

Drug(s) Affected By Kynurenine 3-monooxygenase (KMO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[241]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[687]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[479]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[226]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[306]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[228]

Drug(s) Affected By Stathmin-4 (STMN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[273]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[302]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[302]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[479]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]

Drug(s) Affected By Histone-lysine N-methyltransferase 2A (KMT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[832]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[833]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[197]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[834]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[835]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[836]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]

Drug(s) Affected By Protein lyl-1 (LYL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[548]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[177]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[114]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[308]

Drug(s) Affected By Metalloproteinase inhibitor 3 (TIMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[341]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[837]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[331]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[333]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[316]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[179]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]

Drug(s) Affected By Tumor protein p53-inducible protein 11 (TP53I11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[838]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[375]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[231]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[624]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[105]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[839]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[101]

Drug(s) Affected By Hepatocyte growth factor (HGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[840]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[489]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[841]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[841]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[375]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[842]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[843]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[844]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[845]

Drug(s) Affected By Multidrug resistance-associated protein 1 (ABCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[846]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[847]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[848]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[849]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[850]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[259]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[851]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[852]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[853]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[853]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[854]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[153]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[855]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[856]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[796]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[857]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[858]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[859]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[860]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[659]

Drug(s) Affected By 14-3-3 protein sigma (SFN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[175]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[533]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[242]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[313]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[861]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[128]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[313]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[79]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[374]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[862]

Drug(s) Affected By Protein kinase C zeta type (PRKCZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[863]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[116]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[226]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[864]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[865]

Drug(s) Affected By Calcitonin receptor (CALCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[248]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[430]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[866]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[312]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[228]

Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[859]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[228]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[867]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[153]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[868]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[195]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[869]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[870]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]

Drug(s) Affected By Glutathione S-transferase Mu 1 (GSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[871]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[872]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[272]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[873]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[335]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[335]
Methyldopa	DM5I621	Hypertension	BA00-BA04	Approved	[874]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]

Drug(s) Affected By Methylenetetrahydrofolate reductase (MTHFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[875]
Benazepril	DMH1M9B	Hypertension	BA00-BA04	Approved	[876]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[877]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[878]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[226]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[117]

Drug(s) Affected By Deoxycytidine kinase (DCK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[548]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[146]
Emtricitabine	DMBMUWZ	Hepatitis virus infection	1E50-1E51	Approved	[879]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[131]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[166]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Herpes simplex virus DNA polymerase UL30 (HSV UL30)	TTIU7X1	DPOL_HHV11	Inhibitor	[3]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Equilibrative nucleoside transporter 2 (SLC29A2)	DTW78DQ	S29A2_HUMAN	Substrate	[4]
Concentrative nucleoside transporter 1 (SLC28A1)	DT0EQPW	S28A1_HUMAN	Substrate	[4]
Equilibrative nucleoside transporter 1 (SLC29A1)	DTXD1TQ	S29A1_HUMAN	Substrate	[4]
Organic cation/carnitine transporter 1 (SLC22A4)	DT2EG60	S22A4_HUMAN	Substrate	[5]
Organic cation transporter 1 (SLC22A1)	DTT79CX	S22A1_HUMAN	Substrate	[6]
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[7]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[8]
Cytidine aminohydrolase (CDA)	DEKEDRC	CDD_HUMAN	Substrate	[9]
Ecto-5'-nucleotidase (NT5E)	DE3Z9HM	5NTD_HUMAN	Substrate	[9]
Deoxycytidylate deaminase (DCTD)	DEXL3P2	DCTD_HUMAN	Substrate	[9]
Cytidine deaminase (cdd)	DEYILK4	E0TLJ6_MYCHH	Substrate	[10]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 (PLCB2)	OTPAHDGO	PLCB2_HUMAN	Protein Interaction/Cellular Processes	[11]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 (PLCH1)	OT6Z1L2E	PLCH1_HUMAN	Gene/Protein Processing	[12]
14-3-3 protein sigma (SFN)	OTLJCZ1U	1433S_HUMAN	Drug Response	[13]
3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B)	OTOA8WU2	PDE4B_HUMAN	Gene/Protein Processing	[12]
5'-3' exonuclease PLD3 (PLD3)	OTL07SP2	PLD3_HUMAN	Gene/Protein Processing	[12]
A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1)	OTTLJH8W	ATS1_HUMAN	Gene/Protein Processing	[12]
A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9)	OTV3Q0DS	ATS9_HUMAN	Gene/Protein Processing	[12]
Actin filament-associated protein 1-like 2 (AFAP1L2)	OTJBI0VN	AF1L2_HUMAN	Gene/Protein Processing	[12]
Actin, alpha cardiac muscle 1 (ACTC1)	OTJU04B1	ACTC_HUMAN	Gene/Protein Processing	[12]
Actin, alpha skeletal muscle (ACTA1)	OTOVGLPG	ACTS_HUMAN	Gene/Protein Processing	[12]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4827).
• [2] Cytarabine FDA Label
• [3] Chromatin-associated proteins HMGB1/2 and PDIA3 trigger cellular response to chemotherapy-induced DNA damage. Mol Cancer Ther. 2009 Apr;8(4):864-72.
• [4] FLT3 is implicated in cytarabine transport by human equilibrative nucleoside transporter 1 in pediatric acute leukemia. Oncotarget. 2016 Aug 2;7(31):49786-49799.
• [5] OCTN1 Is a High-Affinity Carrier of Nucleoside Analogues. Cancer Res. 2017 Apr 15;77(8):2102-2111.
• [6] Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
• [7] Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
• [8] Synthesis and characterization of a novel liver-targeted prodrug of cytosine-1-beta-D-arabinofuranoside monophosphate for the treatment of hepatocellular carcinoma. J Med Chem. 2006 Dec 28;49(26):7711-20.
• [9] Genetic factors influencing cytarabine therapy. Pharmacogenomics. 2009 Oct;10(10):1657-74.
• [10] Mycoplasma hyorhinis-encoded cytidine deaminase efficiently inactivates cytosine-based anticancer drugs. FEBS Open Bio. 2015 Aug 3;5:634-9.
• [11] Protein kinase CbetaII activation by 1-beta-D-arabinofuranosylcytosine is antagonistic to stimulation of apoptosis and Bcl-2alpha down-regulation. J Biol Chem. 1997 Sep 19;272(38):23481-4. doi: 10.1074/jbc.272.38.23481.
• [12] Cytosine arabinoside induces ectoderm and inhibits mesoderm expression in human embryonic stem cells during multilineage differentiation. Br J Pharmacol. 2011 Apr;162(8):1743-56.
• [13] Reversible epigenetic regulation of 14-3-3 expression in acquired gemcitabine resistance by uhrf1 and DNA methyltransferase 1. Mol Pharmacol. 2014 Nov;86(5):561-9. doi: 10.1124/mol.114.092544. Epub 2014 Sep 4.
• [14] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [15] Application of real time polymerase chain reaction to the diagnosis and treatment of cytomegalovirus infection after allogeneic hematopoietic stem cell transplantation. Zhonghua Xue Ye Xue Za Zhi. 2009 Feb;30(2):77-81.
• [16] Extensive oral shedding of human herpesvirus 8 in a renal allograft recipient. Oral Microbiol Immunol. 2009 Apr;24(2):109-15.
• [17] Drug targets in cytomegalovirus infection. Infect Disord Drug Targets. 2009 Apr;9(2):201-22.
• [18] Antimicrobial strategies: inhibition of viral polymerases by 3'-hydroxyl nucleosides. Drugs. 2009;69(2):151-66.
• [19] Penciclovir cream--improved topical treatment for herpes simplex infections. Skin Pharmacol Physiol. 2004 Sep-Oct;17(5):214-8.
• [20] Current pharmacological approaches to the therapy of varicella zoster virus infections: a guide to treatment. Drugs. 1999 Feb;57(2):187-206.
• [21] MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents. Cancer Chemother Pharmacol. 2009 Jun;64(1):183-8.
• [22] Folate transporter expression decreases in the human placenta throughout pregnancy and in pre-eclampsia. Pregnancy Hypertens. 2012 Apr;2(2):123-31.
• [23] Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8.
• [24] Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92.
• [25] Association of genetic polymorphisms in the influx transporter SLCO1B3 and the efflux transporter ABCB1 with imatinib pharmacokinetics in patients with chronic myeloid leukemia. Ther Drug Monit. 2011 Apr;33(2):244-50.
• [26] Are organic cation transporters capable of transporting prostaglandins? Naunyn Schmiedebergs Arch Pharmacol. 2005 Aug;372(2):125-30.
• [27] Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and multidrug and toxin extrusion family). J Pharmacol Exp Ther. 2006 Nov;319(2):879-86.
• [28] Pharmacologic markers and predictors of responses to imatinib therapy in patients with chronic myeloid leukemia. Leuk Lymphoma. 2008 Apr;49(4):639-42.
• [29] Organic cation transporters are determinants of oxaliplatin cytotoxicity. Cancer Res. 2006 Sep 1;66(17):8847-57.
• [30] Implications of genetic polymorphisms in drug transporters for pharmacotherapy. Cancer Lett. 2006 Mar 8;234(1):4-33.
• [31] Upregulation of histone acetylation reverses organic anion transporter 2 repression and enhances 5-fluorouracil sensitivity in hepatocellular carcinoma
• [32] Comparison of type I and type II organic cation transport by organic cation transporters and organic anion-transporting polypeptides. J Pharmacol Exp Ther. 2001 Jul;298(1):110-5.
• [33] Organic cation transporters and their pharmacokinetic and pharmacodynamic consequences. Drug Metab Pharmacokinet. 2008;23(4):243-53.
• [34] Influx Transport of Cationic Drug at the Blood-Retinal Barrier: Impact on the Retinal Delivery of Neuroprotectants. Biol Pharm Bull. 2017;40(8):1139-1145.
• [35] Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. J Pharmacol Exp Ther. 1999 May;289(2):768-73.
• [36] Spontaneous development of intestinal and colonic atrophy and inflammation in the carnitine-deficient jvs (OCTN2(-/-)) mice. Mol Genet Metab. 2007 Dec;92(4):315-24.
• [37] Effects of genetic variation in the novel organic cation transporter, OCTN1, on the renal clearance of gabapentin. Clin Pharmacol Ther. 2008 Mar;83(3):416-21.
• [38] Transport of ipratropium, an anti-chronic obstructive pulmonary disease drug, is mediated by organic cation/carnitine transporters in human bronchial epithelial cells: implications for carrier-mediated pulmonary absorption. Mol Pharm. 2010 Feb 1;7(1):187-95.
• [39] Functional effects of protein sequence polymorphisms in the organic cation/ergothioneine transporter OCTN1 (SLC22A4). Pharmacogenet Genomics. 2007 Sep;17(9):773-82.
• [40] Pancreatic Cancer Chemoresistance to Gemcitabine. Cancers (Basel). 2017 Nov 16;9(11).
• [41] Electrophysiological recordings of CNT1 (SLC28A1) activity on Nanions SURFE2R N1.
• [42] Lonsurf, INN-trifluridine/tipiracil.
• [43] Human equilibrative nucleoside transporter 1, as a predictor of 5-fluorouracil resistance in human pancreatic cancer. Anticancer Res. 2007 Jul-Aug;27(4B):2241-9.
• [44] PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA2040)
• [45] Multiple SLC and ABC Transporters Contribute to the Placental Transfer of Entecavir. Drug Metab Dispos. 2017 Mar;45(3):269-278.
• [46] Effects of dipyridamole coadministration on the pharmacokinetics of ribavirin in healthy volunteers. Drug Metab Pharmacokinet. 2013;28(5):406-10.
• [47] Cytarabine-resistant leukemia cells are moderately sensitive to clofarabine in vitro. Anticancer Res. 2014 Apr;34(4):1657-62.
• [48] Nitric oxide reduces adenosine transporter ENT1 gene (SLC29A1) promoter activity in human fetal endothelium from gestational diabetes. J Cell Physiol. 2006 Aug;208(2):451-60.
• [49] Transport of A1 adenosine receptor agonist tecadenoson by human and mouse nucleoside transporters: evidence for blood-brain barrier transport by murine equilibrative nucleoside transporter 1 mENT1. Drug Metab Dispos. 2013 Apr;41(4):916-22.
• [50] Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines. Cancer. 2007 Mar 1;109(5):957-65.
• [51] Contribution of human hepatic cytochrome P450 isoforms to regioselective hydroxylation of steroid hormones. Xenobiotica. 1998 Jun;28(6):539-47.
• [52] Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6. J Pharmacol Exp Ther. 2004 Sep;310(3):1062-75.
• [53] Isoform-specific regulation of cytochromes P450 expression by estradiol and progesterone. Drug Metab Dispos. 2013 Feb;41(2):263-9.
• [54] Metabolic interactions between acetaminophen (paracetamol) and two flavonoids, luteolin and quercetin, through in-vitro inhibition studies. J Pharm Pharmacol. 2017 Dec;69(12):1762-1772.
• [55] Potent mechanism-based inhibition of CYP3A4 by imatinib explains its liability to interact with CYP3A4 substrates. Br J Pharmacol. 2012 Apr;165(8):2787-98.
• [56] Effects of morin on the pharmacokinetics of etoposide in rats. Biopharm Drug Dispos. 2007 Apr;28(3):151-6.
• [57] The metabolism of zidovudine by human liver microsomes in vitro: formation of 3'-amino-3'-deoxythymidine. Biochem Pharmacol. 1994 Jul 19;48(2):267-76.
• [58] Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
• [59] Equilibrative nucleoside transporter 1 genotype, cytidine deaminase activity and age predict gemcitabine plasma clearance in patients with solid tumours. Br J Clin Pharmacol. 2011 Mar;71(3):437-44.
• [60] Augmentation of the antitumor activity of capecitabine by a tumor selective dihydropyrimidine dehydrogenase inhibitor, RO0094889. Int J Cancer. 2003 Sep 20;106(5):799-805.
• [61] A pilot pharmacokinetic study of oral azacitidine. Leukemia. 2008 Sep;22(9):1680-4.
• [62] Tracking decitabine incorporation into malignant myeloid cell DNA in vitro and in vivo by LC-MS/MS with enzymatic digestion. Sci Rep. 2019 Mar 14;9(1):4558.
• [63] Characteristics of P388/VMDRC.04, a simple, sensitive model for studying P-glycoprotein antagonists. Cancer Res. 1994 Feb 1;54(3):730-7.
• [64] Michaelis-Menten kinetic analysis of drugs of abuse to estimate their affinity to human P-glycoprotein. Toxicol Lett. 2013 Feb 27;217(2):137-42. doi: 10.1016/j.toxlet.2012.12.012. Epub 2012 Dec 27.
• [65] Editor's Highlight: PlacentalDisposition and Effects of Crizotinib: An Ex Vivo Study in the Isolated Dual-Side Perfused Human Cotyledon. Toxicol Sci. 2017 Jun 1;157(2):500-509. doi: 10.1093/toxsci/kfx063.
• [66] Functional evaluation of polymorphisms in the human ABCB1 gene and the impact on clinical responses of antiepileptic drugs. Pharmacogenet Genomics. 2008 May;18(5):390-402. doi: 10.1097/FPC.0b013e3282f85e36.
• [67] Cepharanthine potently enhances the sensitivity of anticancer agents in K562 cells. Cancer Sci. 2005 Jun;96(6):372-6. doi: 10.1111/j.1349-7006.2005.00057.x.
• [68] Clinical pharmacokinetic monitoring of itraconazole is warranted in only a subset of patients. Ther Drug Monit. 2005 Jun;27(3):322-33. doi: 10.1097/01.ftd.0000150135.22645.ea.
• [69] Evaluation of antipsychotic drugs as inhibitors of multidrug resistance transporter P-glycoprotein. Psychopharmacology (Berl). 2006 Sep;187(4):415-23. doi: 10.1007/s00213-006-0437-9. Epub 2006 Jun 30.
• [70] Actions of the selective protein kinase C inhibitor PKC412 on B-chronic lymphocytic leukemia cells in vitro. Haematologica. 2002 Feb;87(2):167-76.
• [71] Characterization of the ATPase activity of the Mr 170,000 to 180,000 membrane glycoprotein (P-glycoprotein) associated with multidrug resistance in K562/ADM cells. Cancer Res. 1988 Sep 1;48(17):4926-32.
• [72] Schedule-dependent therapeutic effects of gemcitabine combined with uracil-tegafur in a human pancreatic cancer xenograft model. Pancreas. 2006 Aug;33(2):142-7. doi: 10.1097/01.mpa.0000226882.48204.26.
• [73] Functional role of the polymorphic 647 T/C variant of ENT1 (SLC29A1) and its association with alcohol withdrawal seizures. PLoS One. 2011 Jan 24;6(1):e16331. doi: 10.1371/journal.pone.0016331.
• [74] Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
• [75] Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
• [76] Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23. doi: 10.1007/s00204-013-1169-3. Epub 2013 Nov 30.
• [77] Rifampin Regulation of Drug Transporters Gene Expression and the Association of MicroRNAs in Human Hepatocytes. Front Pharmacol. 2016 Apr 26;7:111.
• [78] Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
• [79] A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
• [80] Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
• [81] Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
• [82] Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
• [83] Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
• [84] The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
• [85] The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells. Leukemia. 2009 Jun;23(6):1019-28.
• [86] Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
• [87] Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
• [88] Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
• [89] mTOR inhibition reverses acquired endocrine therapy resistance of breast cancer cells at the cell proliferation and gene-expression levels. Cancer Sci. 2008 Oct;99(10):1992-2003. doi: 10.1111/j.1349-7006.2008.00955.x.
• [90] Time series analysis of oxidative stress response patterns in HepG2: a toxicogenomics approach. Toxicology. 2013 Apr 5;306:24-34.
• [91] Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells. Eur J Pharmacol. 2014 Jun 5;732:60-7.
• [92] Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy. Med Oncol. 2011 Dec;28(4):1395-404. doi: 10.1007/s12032-010-9603-3. Epub 2010 Jul 2.
• [93] Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
• [94] Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
• [95] Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
• [96] Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
• [97] Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
• [98] Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
• [99] Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
• [100] Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. Genome Res. 2012 Nov;22(11):2153-62.
• [101] Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
• [102] Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
• [103] The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
• [104] Targeting iron homeostasis induces cellular differentiation and synergizes with differentiating agents in acute myeloid leukemia. J Exp Med. 2010 Apr 12;207(4):731-50. doi: 10.1084/jem.20091488. Epub 2010 Apr 5.
• [105] Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
• [106] Gamma-irradiation and doxorubicin treatment of normal human cells cause cell cycle arrest via different pathways. Mol Cells. 2005 Dec 31;20(3):331-8.
• [107] Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(a)pyrene. Toxicol Sci. 2010 Apr;114(2):247-59.
• [108] Cordycepin inhibits the proliferation and progression of NPC by targeting the MAPK/ERK and -catenin pathways. Oncol Lett. 2022 Jan;23(1):20. doi: 10.3892/ol.2021.13138. Epub 2021 Nov 16.
• [109] From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
• [110] Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
• [111] Cyclosporine A--induced oxidative stress in human renal mesangial cells: a role for ERK 1/2 MAPK signaling. Toxicol Sci. 2012 Mar;126(1):101-13.
• [112] The genomic response of a human uterine endometrial adenocarcinoma cell line to 17alpha-ethynyl estradiol. Toxicol Sci. 2009 Jan;107(1):40-55.
• [113] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
• [114] Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
• [115] Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
• [116] Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
• [117] 17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.
• [118] Targeting MYCN in neuroblastoma by BET bromodomain inhibition. Cancer Discov. 2013 Mar;3(3):308-23.
• [119] Cystathionine metabolic enzymes play a role in the inflammation resolution of human keratinocytes in response to sub-cytotoxic formaldehyde exposure. Toxicol Appl Pharmacol. 2016 Nov 1;310:185-194.
• [120] Dihydrofolate reductase deficiency due to a homozygous DHFR mutation causes megaloblastic anemia and cerebral folate deficiency leading to severe neurologic disease. Am J Hum Genet. 2011 Feb 11;88(2):226-31. doi: 10.1016/j.ajhg.2011.01.007.
• [121] Role of caveolin 1, E-cadherin, Enolase 2 and PKCalpha on resistance to methotrexate in human HT29 colon cancer cells. BMC Med Genomics. 2008 Aug 11;1:35. doi: 10.1186/1755-8794-1-35.
• [122] Investigation of the effects of some drugs and phenolic compounds on human dihydrofolate reductase activity. J Biochem Mol Toxicol. 2015 Mar;29(3):135-9.
• [123] Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
• [124] JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Oncogene. 2008 Aug 28;27(37):5033-44.
• [125] Nicotine modulates the expression of a diverse set of genes in the neuronal SH-SY5Y cell line. J Biol Chem. 2003 May 2;278(18):15633-40.
• [126] Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
• [127] Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Redox Biol. 2020 Jan;28:101321. doi: 10.1016/j.redox.2019.101321. Epub 2019 Sep 5.
• [128] Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
• [129] A comprehensive analysis of Wnt/beta-catenin signaling pathway-related genes and crosstalk pathways in the treatment of As2O3 in renal cancer. Ren Fail. 2018 Nov;40(1):331-339.
• [130] Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
• [131] Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
• [132] Neuronal and cardiac toxicity of pharmacological compounds identified through transcriptomic analysis of human pluripotent stem cell-derived embryoid bodies. Toxicol Appl Pharmacol. 2021 Dec 15;433:115792. doi: 10.1016/j.taap.2021.115792. Epub 2021 Nov 3.
• [133] Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
• [134] Reduction of synovial sublining layer inflammation and proinflammatory cytokine expression in psoriatic arthritis treated with methotrexate. Arthritis Rheum. 2004 Oct;50(10):3286-95. doi: 10.1002/art.20518.
• [135] Expression profile analysis of human peripheral blood mononuclear cells in response to aspirin. Arch Immunol Ther Exp (Warsz). 2005 Mar-Apr;53(2):151-8.
• [136] Phase IIa trial of fingolimod for amyotrophic lateral sclerosis demonstrates acceptable acute safety and tolerability. Muscle Nerve. 2017 Dec;56(6):1077-1084. doi: 10.1002/mus.25733. Epub 2017 Aug 29.
• [137] Transcriptome profile analysis of saturated aliphatic aldehydes reveals carbon number-specific molecules involved in pulmonary toxicity. Chem Res Toxicol. 2014 Aug 18;27(8):1362-70.
• [138] Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
• [139] Chronic ethanol exposure increases goosecoid (GSC) expression in human embryonic carcinoma cell differentiation. J Appl Toxicol. 2014 Jan;34(1):66-75.
• [140] Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell. 2009 Aug 21;138(4):645-659. doi: 10.1016/j.cell.2009.06.034. Epub 2009 Aug 13.
• [141] In vitro and in vivo irinotecan-induced changes in expression profiles of cell cycle and apoptosis-associated genes in acute myeloid leukemia cells. Mol Cancer Ther. 2005 Jun;4(6):885-900.
• [142] Fetal-sex dependent genomic responses in the circulating lymphocytes of arsenic-exposed pregnant women in New Hampshire. Reprod Toxicol. 2017 Oct;73:184-195. doi: 10.1016/j.reprotox.2017.07.023. Epub 2017 Aug 6.
• [143] Effects of Y-27632 on the osteogenic and adipogenic potential of human dental pulp stem cells in vitro. Hum Exp Toxicol. 2022 Jan-Dec;41:9603271221089003. doi: 10.1177/09603271221089003.
• [144] Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. Arch Toxicol. 2016 Jan;90(1):159-80.
• [145] Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 Feb 26;10(1):3450. doi: 10.1038/s41598-020-59827-1.
• [146] Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
• [147] Gene expression profile of human lymphoid CEM cells sensitive and resistant to glucocorticoid-evoked apoptosis. Genomics. 2003 Jun;81(6):543-55.
• [148] Identification of biomarkers and outcomes of endocrine disruption in human ovarian cortex using In Vitro Models. Toxicology. 2023 Feb;485:153425. doi: 10.1016/j.tox.2023.153425. Epub 2023 Jan 5.
• [149] Comparative gene expression analysis of a chronic myelogenous leukemia cell line resistant to cyclophosphamide using oligonucleotide arrays and response to tyrosine kinase inhibitors. Leuk Res. 2007 Nov;31(11):1511-20.
• [150] Comparison of anti-inflammatory and clinical effects of beclomethasone dipropionate and salmeterol in moderate asthma. Eur Respir J. 2002 Jul;20(1):66-72. doi: 10.1183/09031936.02.00094202.
• [151] Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
• [152] Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.
• [153] The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
• [154] Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
• [155] Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
• [156] Human 3D multicellular microtissues: an upgraded model for the in vitro mechanistic investigation of inflammation-associated drug toxicity. Toxicol Lett. 2019 Sep 15;312:34-44.
• [157] FCGR2A and FCGR3A polymorphisms associated with clinical outcome of epidermal growth factor receptor expressing metastatic colorectal cancer patients treated with single-agent cetuximab. J Clin Oncol. 2007 Aug 20;25(24):3712-8. doi: 10.1200/JCO.2006.08.8021.
• [158] Inhibiting Heat Shock Proteins Can Potentiate the Cytotoxic Effect of Cannabidiol in Human Glioma Cells. Anticancer Res. 2015 Nov;35(11):5827-37.
• [159] Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
• [160] Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
• [161] Quantitative proteomic analysis of HepG2 cells treated with quercetin suggests IQGAP1 involved in quercetin-induced regulation of cell proliferation and migration. OMICS. 2009 Apr;13(2):93-103. doi: 10.1089/omi.2008.0075.
• [162] D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis. Apoptosis. 2012 Oct;17(10):1079-94.
• [163] Arsenic trioxide induces Hsp70 expression via reactive oxygen species and JNK pathway in MDA231 cells. Life Sci. 2005 Oct 14;77(22):2783-93. doi: 10.1016/j.lfs.2005.04.024.
• [164] Gene expression changes in human small airway epithelial cells exposed to Delta9-tetrahydrocannabinol. Toxicol Lett. 2005 Aug 14;158(2):95-107.
• [165] Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
• [166] A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo. Carcinogenesis. 2012 Jul;33(7):1421-9.
• [167] Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
• [168] S100P is selectively upregulated in tumor cell lines challenged with DNA cross-linking agents. Leuk Res. 2005 Oct;29(10):1181-90. doi: 10.1016/j.leukres.2005.03.012.
• [169] Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur J Nutr. 2005 Mar;44(3):143-56. doi: 10.1007/s00394-004-0503-1. Epub 2004 Apr 30.
• [170] Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4050-61.
• [171] Using a customized DNA microarray for expression profiling of the estrogen-responsive genes to evaluate estrogen activity among natural estrogens and industrial chemicals. Environ Health Perspect. 2004 May;112(7):773-81. doi: 10.1289/ehp.6753.
• [172] Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
• [173] Extracellular ATP drives breast cancer cell migration and metastasis via S100A4 production by cancer cells and fibroblasts. Cancer Lett. 2018 Aug 28;430:1-10. doi: 10.1016/j.canlet.2018.04.043. Epub 2018 May 5.
• [174] 14-3-3 regulation of and interaction with YAP1 in acquired gemcitabine resistance via promoting ribonucleotide reductase expression. Oncotarget. 2016 Apr 5;7(14):17726-36. doi: 10.18632/oncotarget.7394.
• [175] Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
• [176] Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
• [177] Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells. J Biol Chem. 2012 Dec 14;287(51):43137-55.
• [178] Comparative DNA microarray analysis of human monocyte derived dendritic cells and MUTZ-3 cells exposed to the moderate skin sensitizer cinnamaldehyde. Toxicol Appl Pharmacol. 2009 Sep 15;239(3):273-83.
• [179] Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
• [180] Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
• [181] Bone marrow osteoblast damage by chemotherapeutic agents. PLoS One. 2012;7(2):e30758. doi: 10.1371/journal.pone.0030758. Epub 2012 Feb 17.
• [182] Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity. Toxicology. 2014 Jan 6;315:8-16. doi: 10.1016/j.tox.2013.10.009. Epub 2013 Nov 6.
• [183] The effect of DNA methylation inhibitor 5-Aza-2'-deoxycytidine on human endometrial stromal cells. Hum Reprod. 2010 Nov;25(11):2859-69.
• [184] Expression profiling of nucleotide metabolism-related genes in human breast cancer cells after treatment with 5-fluorouracil. Cancer Invest. 2009 Jun;27(5):561-7.
• [185] Persistent and non-persistent changes in gene expression result from long-term estrogen exposure of MCF-7 breast cancer cells. J Steroid Biochem Mol Biol. 2011 Feb;123(3-5):140-50.
• [186] Amiodarone sensitizes human glioma cells but not astrocytes to TRAIL-induced apoptosis via CHOP-mediated DR5 upregulation. Neuro Oncol. 2011 Mar;13(3):267-79. doi: 10.1093/neuonc/noq195. Epub 2011 Feb 3.
• [187] Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
• [188] Two distinct phases of virus-induced nuclear factor kappa B regulation enhance tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in virus-infected cells. J Biol Chem. 2003 May 16;278(20):18092-100. doi: 10.1074/jbc.M300265200. Epub 2003 Mar 13.
• [189] TNF-related apoptosis-inducing ligand cooperates with NSAIDs via activated Wnt signalling in (pre)malignant colon cells. J Pathol. 2011 Feb;223(3):378-89. doi: 10.1002/path.2797. Epub 2010 Oct 29.
• [190] Peripheral blood expression of nuclear factor-kappab-regulated genes is associated with rheumatoid arthritis disease activity and responds differentially to anti-tumor necrosis factor-alpha versus methotrexate. J Rheumatol. 2007 Sep;34(9):1817-22. Epub 2007 Aug 1.
• [191] Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model. Toxicol In Vitro. 2009 Oct;23(7):1387-95.
• [192] Benzodithiophenes potentiate differentiation of acute promyelocytic leukemia cells by lowering the threshold for ligand-mediated corepressor/coactivator exchange with retinoic acid receptor alpha and enhancing changes in all-trans-retinoic acid-regulated gene expression. Cancer Res. 2005 Sep 1;65(17):7856-65. doi: 10.1158/0008-5472.CAN-05-1056.
• [193] Gene microarray analysis of human renal cell carcinoma: the effects of HDAC inhibition and retinoid treatment. Cancer Biol Ther. 2008 Oct;7(10):1607-18.
• [194] Cannabidiol and Oxygen-Ozone Combination Induce Cytotoxicity in Human Pancreatic Ductal Adenocarcinoma Cell Lines. Cancers (Basel). 2020 Sep 27;12(10):2774. doi: 10.3390/cancers12102774.
• [195] Quercetin and Its Fermented Extract as a Potential Inhibitor of Bisphenol A-Exposed HT-29 Colon Cancer Cells' Viability. Int J Mol Sci. 2023 Mar 15;24(6):5604. doi: 10.3390/ijms24065604.
• [196] Synergistic antiproliferative effect of arsenic trioxide combined with bortezomib in HL60 cell line and primary blasts from patients affected by myeloproliferative disorders. Cancer Genet Cytogenet. 2010 Jun;199(2):110-20. doi: 10.1016/j.cancergencyto.2010.02.010.
• [197] THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
• [198] The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
• [199] Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions. Toxicol In Vitro. 2009 Apr;23(3):466-75. doi: 10.1016/j.tiv.2008.12.018. Epub 2008 Dec 30.
• [200] Dose- and time-dependent transcriptional response of Ishikawa cells exposed to genistein. Toxicol Sci. 2016 May;151(1):71-87.
• [201] Cisplatin transiently up-regulates hHR23 expression through enhanced translational efficiency in A549 adenocarcinoma cells. Toxicol Lett. 2011 Sep 10;205(3):341-50. doi: 10.1016/j.toxlet.2011.06.028. Epub 2011 Jul 2.
• [202] Application of cDNA microarray to the study of arsenic-induced liver diseases in the population of Guizhou, China. Toxicol Sci. 2001 Jan;59(1):185-92.
• [203] Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
• [204] Glyphosate-based herbicides at low doses affect canonical pathways in estrogen positive and negative breast cancer cell lines. PLoS One. 2019 Jul 11;14(7):e0219610. doi: 10.1371/journal.pone.0219610. eCollection 2019.
• [205] Alternatives for the worse: Molecular insights into adverse effects of bisphenol a and substitutes during human adipocyte differentiation. Environ Int. 2021 Nov;156:106730. doi: 10.1016/j.envint.2021.106730. Epub 2021 Jun 27.
• [206] The contact allergen nickel triggers a unique inflammatory and proangiogenic gene expression pattern via activation of NF-kappaB and hypoxia-inducible factor-1alpha. J Immunol. 2007 Mar 1;178(5):3198-207.
• [207] Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
• [208] Omeprazole inhibits pancreatic cancer cell invasion through a nongenomic aryl hydrocarbon receptor pathway. Chem Res Toxicol. 2015 May 18;28(5):907-18.
• [209] Cannabinoids synergize with carfilzomib, reducing multiple myeloma cells viability and migration. Oncotarget. 2016 Nov 22;7(47):77543-77557. doi: 10.18632/oncotarget.12721.
• [210] Arsenic trioxide inhibits CXCR4-mediated metastasis by interfering miR-520h/PP2A/NF-B signaling in cervical cancer. Ann Surg Oncol. 2014 Dec;21 Suppl 4:S687-95. doi: 10.1245/s10434-014-3812-5. Epub 2014 Jul 22.
• [211] Etodolac induces apoptosis and inhibits cell adhesion to bone marrow stromal cells in human myeloma cells. Leuk Res. 2006 Feb;30(2):123-35. doi: 10.1016/j.leukres.2005.06.009. Epub 2005 Jul 25.
• [212] MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia. Cell Biol Toxicol. 2023 Feb;39(1):201-216. doi: 10.1007/s10565-021-09639-4. Epub 2021 Sep 28.
• [213] Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7653-8.
• [214] Regulation of antiprotease and antimicrobial protein secretion by airway submucosal gland serous cells. J Biol Chem. 2004 Sep 10;279(37):38854-60. doi: 10.1074/jbc.M407077200. Epub 2004 Jul 2.
• [215] DNA microarray analysis of changes in gene expression induced by 1,25-dihydroxyvitamin D3 in human promyelocytic leukemia HL-60 cells. Biomed Res. 2006 Jun;27(3):99-109. doi: 10.2220/biomedres.27.99.
• [216] Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons. PLoS One. 2009 Sep 23;4(9):e7155.
• [217] Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
• [218] Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
• [219] A systematic assessment of radiation dose enhancement by 5-Aza-2'-deoxycytidine and histone deacetylase inhibitors in head-and-neck squamous cell carcinoma. Int J Radiat Oncol Biol Phys. 2009 Mar 1;73(3):904-12. doi: 10.1016/j.ijrobp.2008.10.032.
• [220] Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Toxicol Appl Pharmacol. 2012 Jun 1;261(2):204-16.
• [221] Propolis alleviates 4-aminobiphenyl-induced oxidative DNA damage by inhibition of CYP2E1 expression in human liver cells. Environ Toxicol. 2021 Aug;36(8):1504-1513. doi: 10.1002/tox.23147. Epub 2021 Apr 13.
• [222] Unpredicted Downregulation of RAD51 Suggests Genome Instability Induced by Tetrachlorobenzoquinone. Chem Res Toxicol. 2016 Dec 19;29(12):2184-2193. doi: 10.1021/acs.chemrestox.6b00369. Epub 2016 Nov 21.
• [223] Molecular characterization of a toxicological tipping point during human stem cell differentiation. Reprod Toxicol. 2020 Jan;91:1-13. doi: 10.1016/j.reprotox.2019.10.001. Epub 2019 Oct 7.
• [224] Inhibitors of class I HDACs and of FLT3 combine synergistically against leukemia cells with mutant FLT3. Arch Toxicol. 2022 Jan;96(1):177-193. doi: 10.1007/s00204-021-03174-1. Epub 2021 Oct 19.
• [225] Changes in gene expression profiles of multiple myeloma cells induced by arsenic trioxide (ATO): possible mechanisms to explain ATO resistance in vivo. Br J Haematol. 2005 Mar;128(5):636-44.
• [226] Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
• [227] Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
• [228] DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
• [229] Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
• [230] Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound. Toxicol In Vitro. 2021 Jun;73:105112. doi: 10.1016/j.tiv.2021.105112. Epub 2021 Feb 22.
• [231] Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92. doi: 10.1016/j.bbrc.2011.08.027. Epub 2011 Aug 16.
• [232] Characterizing the genetic basis for nicotine induced cancer development: a transcriptome sequencing study. PLoS One. 2013 Jun 18;8(6):e67252.
• [233] Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma. Oncotarget. 2014 May 15;5(9):2355-71.
• [234] Sulforaphane-induced apoptosis in human leukemia HL-60 cells through extrinsic and intrinsic signal pathways and altering associated genes expression assayed by cDNA microarray. Environ Toxicol. 2017 Jan;32(1):311-328.
• [235] Global effects of inorganic arsenic on gene expression profile in human macrophages. Mol Immunol. 2009 Feb;46(4):649-56.
• [236] The induction of cytochrome P450 2E1 by ethanol leads to the loss of synaptic proteins via PPARalpha down-regulation. Toxicology. 2017 Jun 15;385:18-27.
• [237] Prolyl endopeptidase is involved in cellular signalling in human neuroblastoma SH-SY5Y cells. Neurosignals. 2011;19(2):97-109. doi: 10.1159/000326342. Epub 2011 Apr 10.
• [238] Persistence of epigenomic effects after recovery from repeated treatment with two nephrocarcinogens. Front Genet. 2018 Dec 3;9:558.
• [239] The thioxotriazole copper(II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cells. J Biol Chem. 2009 Sep 4;284(36):24306-19.
• [240] Cdk4/6 inhibition induces epithelial-mesenchymal transition and enhances invasiveness in pancreatic cancer cells. Mol Cancer Ther. 2012 Oct;11(10):2138-48. doi: 10.1158/1535-7163.MCT-12-0562. Epub 2012 Aug 6.
• [241] Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
• [242] Gene expression profiling of rheumatoid arthritis synovial cells treated with antirheumatic drugs. J Biomol Screen. 2007 Apr;12(3):328-40. doi: 10.1177/1087057107299261. Epub 2007 Mar 22.
• [243] Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
• [244] Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. Arch Toxicol. 2018 Apr;92(4):1453-1469.
• [245] Antiepileptic drugs are endocrine disruptors for the human fetal testis ex vivo. Toxicol Sci. 2023 Sep 28;195(2):169-183. doi: 10.1093/toxsci/kfad076.
• [246] Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018 Nov;121:214-223. doi: 10.1016/j.fct.2018.08.034. Epub 2018 Aug 26.
• [247] Phenethyl isothiocyanate alters the gene expression and the levels of protein associated with cell cycle regulation in human glioblastoma GBM 8401 cells. Environ Toxicol. 2017 Jan;32(1):176-187.
• [248] Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
• [249] Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun. 2008 Dec 19;377(3):797-802.
• [250] Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.
• [251] Exposure to Insecticides Modifies Gene Expression and DNA Methylation in Hematopoietic Tissues In Vitro. Int J Mol Sci. 2023 Mar 26;24(7):6259. doi: 10.3390/ijms24076259.
• [252] The NRF2-mediated oxidative stress response pathway is associated with tumor cell resistance to arsenic trioxide across the NCI-60 panel. BMC Med Genomics. 2010 Aug 13;3:37. doi: 10.1186/1755-8794-3-37.
• [253] Novel ATP-competitive Akt inhibitor afuresertib suppresses the proliferation of malignant pleural mesothelioma cells. Cancer Med. 2017 Nov;6(11):2646-2659. doi: 10.1002/cam4.1179. Epub 2017 Sep 27.
• [254] Functional expression of novel human and murine AKR1B genes. Chem Biol Interact. 2011 May 30;191(1-3):177-84.
• [255] Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
• [256] Genomic and proteomic profiling of responses to toxic metals in human lung cells. Environ Health Perspect. 2003 May;111(6):825-35.
• [257] Co-Administration of Melatonin Effectively Enhances the Therapeutic Effects of Pioglitazone on Mesenchymal Stem Cells Undergoing Indoxyl Sulfate-Induced Senescence through Modulation of Cellular Prion Protein Expression. Int J Mol Sci. 2018 May 4;19(5):1367. doi: 10.3390/ijms19051367.
• [258] Steroid and xenobiotic receptor-mediated effects of bisphenol A on human osteoblasts. Life Sci. 2016 Jun 15;155:29-35.
• [259] Clinical determinants of response to irinotecan-based therapy derived from cell line models. Clin Cancer Res. 2008 Oct 15;14(20):6647-55.
• [260] Gonadal steroids regulate GABAA receptor subunit mRNA expression in NT2-N neurons. Brain Res Mol Brain Res. 2005 Aug 18;138(2):105-15. doi: 10.1016/j.molbrainres.2004.10.047.
• [261] HOXA10 regulates endometrial GABAA {pi} receptor expression and membrane translocation. Am J Physiol Endocrinol Metab. 2010 Apr;298(4):E889-93. doi: 10.1152/ajpendo.00577.2009. Epub 2010 Jan 26.
• [262] CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.
• [263] Folate deficiency in normal human fibroblasts leads to altered expression of genes primarily linked to cell signaling, the cytoskeleton and extracellular matrix. J Nutr Biochem. 2007 Aug;18(8):541-52. doi: 10.1016/j.jnutbio.2006.11.002. Epub 2007 Feb 22.
• [264] Atrial-like Engineered Heart Tissue: An In?Vitro Model of the Human Atrium. Stem Cell Reports. 2018 Dec 11;11(6):1378-1390. doi: 10.1016/j.stemcr.2018.10.008. Epub 2018 Nov 8.
• [265] Influence of Iron on Cytotoxicity and Gene Expression Profiles Induced by Arsenic in HepG2 Cells. Int J Environ Res Public Health. 2019 Nov 14;16(22):4484. doi: 10.3390/ijerph16224484.
• [266] Transcriptional profiling of MCF7 breast cancer cells in response to 5-Fluorouracil: relationship with cell cycle changes and apoptosis, and identification of novel targets of p53. Int J Cancer. 2006 Sep 1;119(5):1164-75.
• [267] Proteomics-based identification of differentially abundant proteins from human keratinocytes exposed to arsenic trioxide. J Proteomics Bioinform. 2014 Jul;7(7):166-178.
• [268] Differential effects of omega-3 and omega-6 Fatty acids on gene expression in breast cancer cells. Breast Cancer Res Treat. 2007 Jan;101(1):7-16. doi: 10.1007/s10549-006-9269-x. Epub 2006 Jul 6.
• [269] Prediction of doxorubicin sensitivity in breast tumors based on gene expression profiles of drug-resistant cell lines correlates with patient survival. Oncogene. 2005 Nov 17;24(51):7542-51. doi: 10.1038/sj.onc.1208908.
• [270] LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
• [271] Gene expression profile induced by BCNU in human glioma cell lines with differential MGMT expression. J Neurooncol. 2005 Jul;73(3):189-98.
• [272] Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
• [273] Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029.
• [274] Analysis of the in vitro synergistic effect of 5-fluorouracil and cisplatin on cervical carcinoma cells. Int J Gynecol Cancer. 2006 May-Jun;16(3):1321-9.
• [275] Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta. Mol Biol Cell. 2004 Mar;15(3):1262-72. doi: 10.1091/mbc.e03-06-0360. Epub 2003 Dec 29.
• [276] Changes in gene expressions elicited by physiological concentrations of genistein on human endometrial cancer cells. Mol Carcinog. 2006 Oct;45(10):752-63.
• [277] Endoplasmic reticulum stress impairs insulin signaling through mitochondrial damage in SH-SY5Y cells. Neurosignals. 2012;20(4):265-80.
• [278] Thyroid hormone responsive genes in cultured human fibroblasts. J Clin Endocrinol Metab. 2005 Feb;90(2):936-43.
• [279] Antiproliferative effect of ascorbic acid is associated with the inhibition of genes necessary to cell cycle progression. PLoS One. 2009;4(2):e4409.
• [280] Constitutive gene expression predisposes morphogen-mediated cell fate responses of NT2/D1 and 27X-1 human embryonal carcinoma cells. Stem Cells. 2007 Mar;25(3):771-8. doi: 10.1634/stemcells.2006-0271. Epub 2006 Nov 30.
• [281] Gene expression signatures after ethanol exposure in differentiating embryoid bodies. Toxicol In Vitro. 2018 Feb;46:66-76.
• [282] Effects of all-trans and 9-cis retinoic acid on differentiating human neural stem cells in vitro. Toxicology. 2023 Mar 15;487:153461. doi: 10.1016/j.tox.2023.153461. Epub 2023 Feb 16.
• [283] Chenodeoxycholic acid significantly impacts the expression of miRNAs and genes involved in lipid, bile acid and drug metabolism in human hepatocytes. Life Sci. 2016 Jul 1;156:47-56.
• [284] Evaluation of developmental toxicity using undifferentiated human embryonic stem cells. J Appl Toxicol. 2015 Feb;35(2):205-18.
• [285] Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium. Mol Hum Reprod. 2007 Sep;13(9):641-54.
• [286] Role of phenytoin in wound healing: microarray analysis of early transcriptional responses in human dermal fibroblasts. Biochem Biophys Res Commun. 2004 Feb 13;314(3):661-6. doi: 10.1016/j.bbrc.2003.12.146.
• [287] Development and validation of the TGx-HDACi transcriptomic biomarker to detect histone deacetylase inhibitors in human TK6 cells. Arch Toxicol. 2021 May;95(5):1631-1645. doi: 10.1007/s00204-021-03014-2. Epub 2021 Mar 26.
• [288] Influence of resveratrol on rheumatoid fibroblast-like synoviocytes analysed with gene chip transcription. Phytomedicine. 2013 Feb 15;20(3-4):310-8. doi: 10.1016/j.phymed.2012.09.020. Epub 2012 Nov 6.
• [289] Research resource: STR DNA profile and gene expression comparisons of human BG-1 cells and a BG-1/MCF-7 clonal variant. Mol Endocrinol. 2014 Dec;28(12):2072-81.
• [290] Noncoding RNA synthesis and loss of Polycomb group repression accompanies the colinear activation of the human HOXA cluster. RNA. 2007 Feb;13(2):223-39. doi: 10.1261/rna.266707. Epub 2006 Dec 21.
• [291] Synergistic effect of JQ1 and rapamycin for treatment of human osteosarcoma. Int J Cancer. 2015 May 1;136(9):2055-64.
• [292] The genomic response of Ishikawa cells to bisphenol A exposure is dose- and time-dependent. Toxicology. 2010 Apr 11;270(2-3):137-49. doi: 10.1016/j.tox.2010.02.008. Epub 2010 Feb 17.
• [293] Effects of progesterone treatment on expression of genes involved in uterine quiescence. Reprod Sci. 2011 Aug;18(8):781-97.
• [294] Targeting hypoxic tumor cell viability with carbohydrate-based carbonic anhydrase IX and XII inhibitors. J Med Chem. 2011 Oct 13;54(19):6905-18.
• [295] Moving toward integrating gene expression profiling into high-throughput testing: a gene expression biomarker accurately predicts estrogen receptor alpha modulation in a microarray compendium. Toxicol Sci. 2016 May;151(1):88-103.
• [296] Design, synthesis, and biological evaluation of novel carbohydrate-based sulfamates as carbonic anhydrase inhibitors. J Med Chem. 2011 Mar 10;54(5):1481-9.
• [297] DNA microarray analysis of vitamin D-induced gene expression in a human colon carcinoma cell line. Physiol Genomics. 2004 Apr 13;17(2):122-9. doi: 10.1152/physiolgenomics.00002.2003.
• [298] Manganese superoxide dismutase induces migration and invasion of tongue squamous cell carcinoma via H2O2-dependent Snail signaling. Free Radic Biol Med. 2012 Jul 1;53(1):44-50. doi: 10.1016/j.freeradbiomed.2012.04.031. Epub 2012 May 9.
• [299] Ciprofloxacin mediates cancer stem cell phenotypes in lung cancer cells through caveolin-1-dependent mechanism. Chem Biol Interact. 2016 Apr 25;250:1-11.
• [300] Endoplasmic reticulum stress contributes to arsenic trioxide-induced intrinsic apoptosis in human umbilical and bone marrow mesenchymal stem cells. Environ Toxicol. 2016 Mar;31(3):314-28.
• [301] Toxicogenomics of kojic acid on gene expression profiling of a375 human malignant melanoma cells. Biol Pharm Bull. 2006 Apr;29(4):655-69.
• [302] Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. PLoS One. 2012;7(12):e53003. doi: 10.1371/journal.pone.0053003. Epub 2012 Dec 27.
• [303] Early gene response in lithium chloride induced apoptosis. Apoptosis. 2005 Jan;10(1):75-90. doi: 10.1007/s10495-005-6063-x.
• [304] Nuclear and Mitochondrial DNA Methylation Patterns Induced by Valproic Acid in Human Hepatocytes. Chem Res Toxicol. 2017 Oct 16;30(10):1847-1854. doi: 10.1021/acs.chemrestox.7b00171. Epub 2017 Sep 13.
• [305] Real-time monitoring of cisplatin-induced cell death. PLoS One. 2011;6(5):e19714. doi: 10.1371/journal.pone.0019714. Epub 2011 May 16.
• [306] Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297. doi: 10.1016/j.fct.2020.111297. Epub 2020 Mar 28.
• [307] A microarray study on the effect of four hormone therapy regimens on gene transcription in whole blood from healthy postmenopausal women. Thromb Res. 2012 Jul;130(1):45-51. doi: 10.1016/j.thromres.2011.12.009. Epub 2012 Jan 2.
• [308] Bisphenol A and bisphenol S induce distinct transcriptional profiles in differentiating human primary preadipocytes. PLoS One. 2016 Sep 29;11(9):e0163318.
• [309] Delta9-tetrahydrocannabinol inhibits cytotrophoblast cell proliferation and modulates gene transcription. Mol Hum Reprod. 2006 May;12(5):321-33. doi: 10.1093/molehr/gal036. Epub 2006 Apr 5.
• [310] Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
• [311] Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells. Chem Res Toxicol. 2014 Mar 17;27(3):408-20.
• [312] Benzo[a]pyrene-induced changes in microRNA-mRNA networks. Chem Res Toxicol. 2012 Apr 16;25(4):838-49.
• [313] Genomic profiling uncovers a molecular pattern for toxicological characterization of mutagens and promutagens in vitro. Toxicol Sci. 2011 Jul;122(1):185-97.
• [314] Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
• [315] Biological specificity of CDK4/6 inhibitors: dose response relationship, in vivo signaling, and composite response signature. Oncotarget. 2017 Jul 4;8(27):43678-43691. doi: 10.18632/oncotarget.18435.
• [316] Arsenic trioxide induces different gene expression profiles of genes related to growth and apoptosis in glioma cells dependent on the p53 status. Mol Biol Rep. 2008 Sep;35(3):421-9.
• [317] Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
• [318] Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner. Carcinogenesis. 2009 Aug;30(8):1320-9. doi: 10.1093/carcin/bgp138. Epub 2009 Jun 5.
• [319] CXCL14 downregulation in human keratinocytes is a potential biomarker for a novel in vitro skin sensitization test. Toxicol Appl Pharmacol. 2020 Jan 1;386:114828. doi: 10.1016/j.taap.2019.114828. Epub 2019 Nov 14.
• [320] Gene expression profiling in Ishikawa cells: a fingerprint for estrogen active compounds. Toxicol Appl Pharmacol. 2009 Apr 1;236(1):85-96.
• [321] Effects of lithium and valproic acid on gene expression and phenotypic markers in an NT2 neurosphere model of neural development. PLoS One. 2013;8(3):e58822.
• [322] Inhibition of prostate cancer cell colony formation by the flavonoid quercetin correlates with modulation of specific regulatory genes. Clin Diagn Lab Immunol. 2004 Jan;11(1):63-9. doi: 10.1128/cdli.11.1.63-69.2004.
• [323] Retinoic acid-induced downmodulation of telomerase activity in human cancer cells. Exp Mol Pathol. 2005 Oct;79(2):108-17.
• [324] Zidovudine induces S-phase arrest and cell cycle gene expression changes in human cells. Mutagenesis. 2005 Mar;20(2):139-46. doi: 10.1093/mutage/gei019. Epub 2005 Mar 22.
• [325] In vitro effects of aldehydes present in tobacco smoke on gene expression in human lung alveolar epithelial cells. Toxicol In Vitro. 2013 Apr;27(3):1072-81.
• [326] Proteomic analysis of human adipose tissue after rosiglitazone treatment shows coordinated changes to promote glucose uptake. Obesity (Silver Spring). 2010 Jan;18(1):27-34. doi: 10.1038/oby.2009.208. Epub 2009 Jun 25.
• [327] Unique signatures of stress-induced senescent human astrocytes. Exp Neurol. 2020 Dec;334:113466. doi: 10.1016/j.expneurol.2020.113466. Epub 2020 Sep 17.
• [328] Effect of spironolactone on impaired fibrinolysis of hypertensive patients. Kidney Blood Press Res. 2002;25(4):260-4. doi: 10.1159/000066348.
• [329] Involvement of retinoic acid receptor alpha in the stimulation of tissue-type plasminogen-activator gene expression in human endothelial cells. Eur J Biochem. 1995 Sep 1;232(2):425-32.
• [330] Relation between long-term steroid treatment after heart transplantation, hypofibrinolysis and myocardial microthrombi generation. J Heart Lung Transplant. 1999 Jul;18(7):693-700. doi: 10.1016/s1053-2498(99)00021-2.
• [331] Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
• [332] Simvastatin increases fibrinolytic activity in human peritoneal mesothelial cells independent of cholesterol lowering. Kidney Int. 2002 Nov;62(5):1611-9. doi: 10.1046/j.1523-1755.2002.00601.x.
• [333] Rofecoxib regulates the expression of genes related to the matrix metalloproteinase pathway in humans: implication for the adverse effects of cyclooxygenase-2 inhibitors. Clin Pharmacol Ther. 2006 Apr;79(4):303-15. doi: 10.1016/j.clpt.2005.12.306.
• [334] Non-nutritional sweeteners effects on endothelial vascular function. Toxicol In Vitro. 2020 Feb;62:104694. doi: 10.1016/j.tiv.2019.104694. Epub 2019 Oct 23.
• [335] Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
• [336] High folic acid increases cell turnover and lowers differentiation and iron content in human HT29 colon cancer cells. Br J Nutr. 2008 Apr;99(4):703-8.
• [337] Prediction of drug-induced liver injury using keratinocytes. J Appl Toxicol. 2017 Jul;37(7):863-872. doi: 10.1002/jat.3435. Epub 2017 Jan 31.
• [338] ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
• [339] Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1. FASEB J. 2012 Apr;26(4):1535-48. doi: 10.1096/fj.11-198184. Epub 2011 Dec 23.
• [340] Discovery of molecular mechanisms of neuroprotection using cell-based bioassays and oligonucleotide arrays. Physiol Genomics. 2002 Oct 29;11(2):45-52. doi: 10.1152/physiolgenomics.00064.2002.
• [341] Inhibition of invasion and induction of apoptosis by selenium in human malignant brain tumour cells in vitro. Int J Oncol. 2007 May;30(5):1263-71.
• [342] Dietary supplementation with the anti-tumour promoter quercetin: its effects on matrix metalloproteinase gene regulation. Mutat Res. 2001 Sep 1;480-481:269-76. doi: 10.1016/s0027-5107(01)00184-1.
• [343] Arsenic trioxide (As2O3) inhibits invasion of HT1080 human fibrosarcoma cells: role of nuclear factor-kappaB and reactive oxygen species. J Cell Biochem. 2005 Aug 1;95(5):955-69. doi: 10.1002/jcb.20452.
• [344] Aspirin inhibits MMP-2 and MMP-9 expressions and activities through upregulation of PPARalpha/gamma and TIMP gene expressions in ox-LDL-stimulated macrophages derived from human monocytes. Pharmacology. 2009;83(1):18-25. doi: 10.1159/000166183. Epub 2008 Oct 30.
• [345] Arsenic trioxide inhibits neuroblastoma growth in vivo and promotes apoptotic cell death in vitro. Biochem Biophys Res Commun. 2000 Oct 14;277(1):179-85. doi: 10.1006/bbrc.2000.3651.
• [346] Release and functional role of neuropeptide Y as a sympathetic modulator in human saphenous vein biopsies. Peptides. 2004 Jan;25(1):53-64. doi: 10.1016/j.peptides.2003.11.001.
• [347] Neuropeptide Y in cortisol-induced hypertension in male volunteers. Clin Exp Pharmacol Physiol. 1994 May;21(5):435-8. doi: 10.1111/j.1440-1681.1994.tb02538.x.
• [348] [Effect of orlistat therapy on carbohydrate, lipid, vitamin and hormone plasma levels in obese subjects]. Pol Arch Med Wewn. 2004 Dec;112(6):1415-23.
• [349] Coordinate up-regulation of TMEM97 and cholesterol biosynthesis genes in normal ovarian surface epithelial cells treated with progesterone: implications for pathogenesis of ovarian cancer. BMC Cancer. 2007 Dec 11;7:223.
• [350] Investigation of in vitro odonto/osteogenic capacity of cannabidiol on human dental pulp cell. J Dent. 2021 Jun;109:103673. doi: 10.1016/j.jdent.2021.103673. Epub 2021 Apr 16.
• [351] Patterns of some extracellular matrix gene expression are similar in cells from cleft lip-palate patients and in human palatal fibroblasts exposed to diazepam in culture. Toxicology. 2009 Mar 4;257(1-2):10-6. doi: 10.1016/j.tox.2008.12.002. Epub 2008 Dec 9.
• [352] Protective effects of myricitrin against osteoporosis via reducing reactive oxygen species and bone-resorbing cytokines. Toxicol Appl Pharmacol. 2014 Nov 1;280(3):550-60.
• [353] Acinar cell-specific knockout of the PTHrP gene decreases the proinflammatory and profibrotic responses in pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2014 Sep 1;307(5):G533-49. doi: 10.1152/ajpgi.00428.2013. Epub 2014 Jul 17.
• [354] The effects of particulate wear debris, cytokines, and growth factors on the functions of MG-63 osteoblasts. J Bone Joint Surg Am. 2001 Feb;83(2):201-11. doi: 10.2106/00004623-200102000-00007.
• [355] Inhibition of systemic sclerosis dermal fibroblast type I collagen production and gene expression by simvastatin. Arthritis Rheum. 2006 Apr;54(4):1298-308. doi: 10.1002/art.21723.
• [356] Antifibrotic effects of quercetin in primary orbital fibroblasts and orbital fat tissue cultures of Graves' orbitopathy. Invest Ophthalmol Vis Sci. 2012 Aug 31;53(9):5921-9. doi: 10.1167/iovs.12-9646.
• [357] SNHG3 cooperates with ELAVL2 to modulate cell apoptosis and extracellular matrix accumulation by stabilizing SNAI2 in human trabecular meshwork cells under oxidative stress. Environ Toxicol. 2021 Jun;36(6):1070-1079. doi: 10.1002/tox.23106. Epub 2021 Feb 1.
• [358] Effect of spironolactone on plasma brain natriuretic peptide and left ventricular remodeling in patients with congestive heart failure. J Am Coll Cardiol. 2001 Apr;37(5):1228-33. doi: 10.1016/s0735-1097(01)01116-0.
• [359] A systems biology strategy reveals biological pathways and plasma biomarker candidates for potentially toxic statin-induced changes in muscle. PLoS One. 2006 Dec 20;1(1):e97. doi: 10.1371/journal.pone.0000097.
• [360] Suppression of insulin-like growth factor signalling pathway and collagen expression in keloid-derived fibroblasts by quercetin: its therapeutic potential use in the treatment and/or prevention of keloids. Br J Dermatol. 2003 Mar;148(3):544-52. doi: 10.1046/j.1365-2133.2003.05174.x.
• [361] Effects of aspirin on metastasis-associated gene expression detected by cDNA microarray. Acta Pharmacol Sin. 2004 Oct;25(10):1327-33.
• [362] Evaluation of early biomarkers of muscle anabolic response to testosterone. J Cachexia Sarcopenia Muscle. 2011 Mar;2(1):45-56. doi: 10.1007/s13539-011-0021-y. Epub 2011 Feb 26.
• [363] Modelling cardiac fibrosis using three-dimensional cardiac microtissues derived from human embryonic stem cells. J Biol Eng. 2019 Feb 13;13:15. doi: 10.1186/s13036-019-0139-6. eCollection 2019.
• [364] Expression pattern of cisplatin-induced metallothionein isoforms in squamous cell carcinoma. Anticancer Res. 2003 Jan-Feb;23(1A):299-303.
• [365] Identification of novel activators of the metal responsive transcription factor (MTF-1) using a gene expression biomarker in a microarray compendium. Metallomics. 2020 Sep 23;12(9):1400-1415. doi: 10.1039/d0mt00071j.
• [366] Expression of antioxidant proteins in human intestinal Caco-2 cells treated with dietary flavonoids. Cancer Lett. 1999 Nov 15;146(2):161-7.
• [367] A new in vitro method for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells. Cutan Ocul Toxicol. 2010 Sep;29(3):171-92.
• [368] Arsenic trioxide (ATO) influences the gene expression of metallothioneins in human glioblastoma cells. Biol Trace Elem Res. 2012 Dec;149(3):331-9.
• [369] Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity. Arch Toxicol. 2018 Jan;92(1):469-485.
• [370] Motexafin gadolinium disrupts zinc metabolism in human cancer cell lines. Cancer Res. 2005 May 1;65(9):3837-45.
• [371] Computational discovery of niclosamide ethanolamine, a repurposed drug candidate that reduces growth of hepatocellular carcinoma cells initro and in mice by inhibiting cell division cycle 37 signaling. Gastroenterology. 2017 Jun;152(8):2022-2036.
• [372] Glucocorticoids inhibit cell death in ovarian cancer and up-regulate caspase inhibitor cIAP2. Clin Cancer Res. 2005 Sep 1;11(17):6325-32. doi: 10.1158/1078-0432.CCR-05-0182.
• [373] Capturing time-dependent activation of genes and stress-response pathways using transcriptomics in iPSC-derived renal proximal tubule cells. Cell Biol Toxicol. 2023 Aug;39(4):1773-1793. doi: 10.1007/s10565-022-09783-5. Epub 2022 Dec 31.
• [374] Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq. Arch Toxicol. 2018 Aug;92(8):2517-2531.
• [375] Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
• [376] Apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma. PLoS One. 2011;6(8):e23569.
• [377] Proteomic identification of differentially expressed proteins associated with the multiple drug resistance in methotrexate-resistant human breast cancer cells. Int J Oncol. 2014 Jul;45(1):448-58.
• [378] The effects of quercetin on SW480 human colon carcinoma cells: a proteomic study. Nutr J. 2005 Mar 4;4:11.
• [379] Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells. Toxicol Sci. 2011 Mar;120(1):109-22.
• [380] Use of transcriptomics in hazard identification and next generation risk assessment: A case study with clothianidin. Food Chem Toxicol. 2022 Aug;166:113212. doi: 10.1016/j.fct.2022.113212. Epub 2022 Jun 8.
• [381] The effects of dasatinib on IgE receptor-dependent activation and histamine release in human basophils. Blood. 2008 Mar 15;111(6):3097-107.
• [382] Positive signaling interactions between arsenic and ethanol for angiogenic gene induction in human microvascular endothelial cells. Toxicol Sci. 2008 Apr;102(2):319-27. doi: 10.1093/toxsci/kfn003. Epub 2008 Jan 8.
• [383] Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray. Cancer Sci. 2006 Jan;97(1):64-71.
• [384] [The discovery of an antiparkinsonian drug, zonisamide]. Rinsho Shinkeigaku. 2010 Feb;50(2):67-73. doi: 10.5692/clinicalneurol.50.67.
• [385] A not cytotoxic nickel concentration alters the expression of neuronal differentiation markers in NT2 cells. Neurotoxicology. 2015 Mar;47:47-53. doi: 10.1016/j.neuro.2015.01.001. Epub 2015 Jan 19.
• [386] Lovastatin induces neuronal differentiation and apoptosis of embryonal carcinoma and neuroblastoma cells: enhanced differentiation and apoptosis in combination with dbcAMP. Mol Cell Biochem. 2010 Dec;345(1-2):1-11. doi: 10.1007/s11010-010-0553-z. Epub 2010 Aug 9.
• [387] Immunohistochemical investigation of dopaminergic terminal markers and caspase-3 activation in the striatum of human methamphetamine users. Int J Legal Med. 2007 May;121(3):163-8. doi: 10.1007/s00414-006-0087-9. Epub 2006 Apr 19.
• [388] A DNA methyltransferase inhibitor, 5-aza-2'-deoxycytidine, exacerbates neurotoxicity and upregulates Parkinson's disease-related genes in dopaminergic neurons. CNS Neurosci Ther. 2013 Mar;19(3):183-90. doi: 10.1111/cns.12059.
• [389] Protein expression profiling identifies molecular targets of quercetin as a major dietary flavonoid in human colon cancer cells. Proteomics. 2004 Jul;4(7):2160-74.
• [390] Arsenic trioxide, retinoic acid and Ara-c regulated the expression of annexin II on the surface of APL cells, a novel co-receptor for plasminogen/tissue plasminogen activator. Thromb Res. 2002 Apr 1;106(1):63-70. doi: 10.1016/s0049-3848(02)00075-0.
• [391] [Clinical study on the fibrinolytic activity in patients with acute promyelocytic leukemia]. Zhonghua Xue Ye Xue Za Zhi. 2009 Mar;30(3):145-9.
• [392] [Effects of thalidomide on Annexin II gene regulation]. Zhonghua Xue Ye Xue Za Zhi. 2009 Jul;30(7):464-7.
• [393] Proteomics analysis of the proliferative effect of low-dose ouabain on human endothelial cells. Biol Pharm Bull. 2007 Feb;30(2):247-53. doi: 10.1248/bpb.30.247.
• [394] Protein profile in neuroblastoma cells incubated with S- and R-enantiomers of ibuprofen by iTRAQ-coupled 2-D LC-MS/MS analysis: possible action of induced proteins on Alzheimer's disease. Proteomics. 2008 Apr;8(8):1595-607. doi: 10.1002/pmic.200700556.
• [395] Cannabidiol Modulates the Expression of Alzheimer's Disease-Related Genes in Mesenchymal Stem Cells. Int J Mol Sci. 2016 Dec 23;18(1):26. doi: 10.3390/ijms18010026.
• [396] [Simvastatin-induced apoptosis of K562 cells is mediated by endoplasmic reticulum stress]. Yao Xue Xue Bao. 2008 Apr;43(4):371-7.
• [397] Quercetin induced cell apoptosis and altered gene expression in AGS human gastric cancer cells. Environ Toxicol. 2018 Nov;33(11):1168-1181. doi: 10.1002/tox.22623. Epub 2018 Aug 27.
• [398] A potential role of calpains in sulfonylureas (SUs) -mediated death of human pancreatic cancer cells (1.2B4). Toxicol In Vitro. 2021 Jun;73:105128. doi: 10.1016/j.tiv.2021.105128. Epub 2021 Feb 27.
• [399] Aspirin Has Antitumor Effects via Expression of Calpain Gene in Cervical Cancer Cells. J Oncol. 2008;2008:285374. doi: 10.1155/2008/285374. Epub 2008 Sep 29.
• [400] Anticancer effects of cantharidin in A431 human skin cancer (Epidermoid carcinoma) cells in vitro and in vivo. Environ Toxicol. 2017 Mar;32(3):723-738. doi: 10.1002/tox.22273. Epub 2016 Apr 25.
• [401] Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts. Biomed Res Int. 2015;2015:257090. doi: 10.1155/2015/257090. Epub 2015 Aug 3.
• [402] p21(WAF1/cip1) is an important determinant of intestinal cell response to sulindac in vitro and in vivo. Cancer Res. 2001 Aug 15;61(16):6297-302.
• [403] Folic acid induces cell type-specific changes in the transcriptome of breast cancer cell lines: a proof-of-concept study. J Nutr Sci. 2016 Apr 26;5:e17. doi: 10.1017/jns.2016.8. eCollection 2016.
• [404] Phenytoin and cyclosporin A suppress the expression of MMP-1, TIMP-1, and cathepsin L, but not cathepsin B in cultured gingival fibroblasts. J Periodontol. 2000 Jun;71(6):955-60. doi: 10.1902/jop.2000.71.6.955.
• [405] The antimalarial amodiaquine causes autophagic-lysosomal and proliferative blockade sensitizing human melanoma cells to starvation- and chemotherapy-induced cell death. Autophagy. 2013 Dec;9(12):2087-102. doi: 10.4161/auto.26506. Epub 2013 Oct 8.
• [406] A role for the autophagy regulator Transcription Factor EB in amiodarone-induced phospholipidosis. Biochem Pharmacol. 2015 Jun 1;95(3):201-9. doi: 10.1016/j.bcp.2015.03.017. Epub 2015 Apr 13.
• [407] Comparison of the gene expression profiles of monocytic versus granulocytic lineages of HL-60 leukemia cell differentiation by DNA microarray analysis. Life Sci. 2003 Aug 15;73(13):1705-19. doi: 10.1016/s0024-3205(03)00515-0.
• [408] Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
• [409] Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer Sci. 2007 Jun;98(6):890-9.
• [410] Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells. Exp Eye Res. 2009 Dec;89(6):995-1002. doi: 10.1016/j.exer.2009.08.011. Epub 2009 Sep 1.
• [411] Primary Human Hepatocyte Spheroids as Tools to Study the Hepatotoxic Potential of Non-Pharmaceutical Chemicals. Int J Mol Sci. 2021 Oct 12;22(20):11005. doi: 10.3390/ijms222011005.
• [412] Cytoskeletal activation and altered gene expression in endothelial barrier regulation by simvastatin. Am J Respir Cell Mol Biol. 2004 May;30(5):662-70. doi: 10.1165/rcmb.2003-0267OC. Epub 2003 Nov 20.
• [413] N-acylation of glucosamine modulates chondrocyte growth, proteoglycan synthesis, and gene expression. J Rheumatol. 2005 Sep;32(9):1775-86.
• [414] Grouping of histone deacetylase inhibitors and other toxicants disturbing neural crest migration by transcriptional profiling. Neurotoxicology. 2015 Sep;50:56-70.
• [415] Combination of atorvastatin and celecoxib synergistically induces cell cycle arrest and apoptosis in colon cancer cells. Int J Cancer. 2008 May 1;122(9):2115-24. doi: 10.1002/ijc.23315.
• [416] Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells. J Cell Biochem. 2006 Aug 1;98(5):1163-84.
• [417] Vitamin K1 Inhibition of Renal Crystal Formation through Matrix Gla Protein in the Kidney. Kidney Blood Press Res. 2019;44(6):1392-1403. doi: 10.1159/000503300. Epub 2019 Oct 22.
• [418] Comparison of replicative senescence and stress-induced premature senescence combining differential display and low-density DNA arrays. FEBS Lett. 2005 Jul 4;579(17):3651-9. doi: 10.1016/j.febslet.2005.05.056.
• [419] Folic acid modulates cancer-associated micro RNAs and inflammatory mediators in neoplastic and non-neoplastic colonic cells in a different way. Mol Nutr Food Res. 2017 Dec;61(12). doi: 10.1002/mnfr.201700260. Epub 2017 Nov 9.
• [420] Chemosensitization by STI571 targeting the platelet-derived growth factor/platelet-derived growth factor receptor-signaling pathway in the tumor progression and angiogenesis of gastric carcinoma. Cancer. 2005 May 1;103(9):1800-9. doi: 10.1002/cncr.20973.
• [421] Levonorgestrel enhances spermatogenesis suppression by testosterone with greater alteration in testicular gene expression in men. Biol Reprod. 2009 Mar;80(3):484-92.
• [422] Gene expression profiling reveals novel regulation by bisphenol-A in estrogen receptor-alpha-positive human cells. Environ Res. 2006 Jan;100(1):86-92.
• [423] Transcriptome and DNA methylation changes modulated by sulforaphane induce cell cycle arrest, apoptosis, DNA damage, and suppression of proliferation in human liver cancer cells. Food Chem Toxicol. 2020 Feb;136:111047. doi: 10.1016/j.fct.2019.111047. Epub 2019 Dec 12.
• [424] Identification of biomarkers modulated by the rexinoid LGD1069 (bexarotene) in human breast cells using oligonucleotide arrays. Cancer Res. 2006 Dec 15;66(24):12009-18.
• [425] Monitoring of deiodinase deficiency based on transcriptomic responses in SH-SY5Y cells. Arch Toxicol. 2013 Jun;87(6):1103-13. doi: 10.1007/s00204-013-1018-4. Epub 2013 Feb 10.
• [426] Expression profiling in squamous carcinoma cells reveals pleiotropic effects of vitamin D3 analog EB1089 signaling on cell proliferation, differentiation, and immune system regulation. Mol Endocrinol. 2002 Jun;16(6):1243-56.
• [427] Identification of novel gene targets and putative regulators of arsenic-associated DNA methylation in human urothelial cells and bladder cancer. Chem Res Toxicol. 2015 Jun 15;28(6):1144-55. doi: 10.1021/tx500393y. Epub 2015 Jun 3.
• [428] Mitogen-activated protein kinases pathway is involved in physiological testosterone-induced tissue factor pathway inhibitor expression in endothelial cells. Blood Coagul Fibrinolysis. 2010 Jul;21(5):420-4. doi: 10.1097/MBC.0b013e328337b475.
• [429] Induction of heme oxygenase-1 by cobalt protoporphyrin enhances the antitumour effect of bortezomib in adult T-cell leukaemia cells. Br J Cancer. 2007 Oct 22;97(8):1099-105. doi: 10.1038/sj.bjc.6604003. Epub 2007 Sep 25.
• [430] Long-term estrogen exposure promotes carcinogen bioactivation, induces persistent changes in gene expression, and enhances the tumorigenicity of MCF-7 human breast cancer cells. Toxicol Appl Pharmacol. 2009 Nov 1;240(3):355-66.
• [431] Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
• [432] Establishment of a 13 genes-based molecular prediction score model to discriminate the neurotoxic potential of food relevant-chemicals. Toxicol Lett. 2022 Feb 1;355:1-18. doi: 10.1016/j.toxlet.2021.10.013. Epub 2021 Nov 5.
• [433] Insulin regulation of hexose transport in mouse 3T3-L1 cells expressing the human HepG2 glucose transporter. J Biol Chem. 1990 Nov 25;265(33):20106-16.
• [434] Effects of troglitazone on cellular differentiation, insulin signaling, and glucose metabolism in cultured human skeletal muscle cells. Biochem Biophys Res Commun. 2001 Jan 26;280(3):664-74. doi: 10.1006/bbrc.2000.4216.
• [435] Disturbance of cellular glucose transport by two prevalently used fluoroquinolone antibiotics ciprofloxacin and levofloxacin involves glucose transporter type 1. Toxicol Lett. 2009 Jan 30;184(2):81-4. doi: 10.1016/j.toxlet.2008.10.017. Epub 2008 Oct 28.
• [436] Increased expression of type VI collagen genes in drug-induced gingival enlargement. FEBS Lett. 1993 Nov 8;334(1):65-8. doi: 10.1016/0014-5793(93)81681-o.
• [437] Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells. Nat Commun. 2018 Aug 9;9(1):3069. doi: 10.1038/s41467-018-05402-2.
• [438] Genomic and proteomic analysis of the effects of cannabinoids on normal human astrocytes. Brain Res. 2008 Jan 29;1191:1-11.
• [439] Human oligodendrocytes derived from embryonic stem cells: Effect of noggin on phenotypic differentiation in vitro and on myelination in vivo. Mol Cell Neurosci. 2007 Mar;34(3):310-23. doi: 10.1016/j.mcn.2006.11.008. Epub 2006 Dec 28.
• [440] Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors. Arch Toxicol. 2021 Feb;95(2):591-615. doi: 10.1007/s00204-020-02970-5. Epub 2021 Jan 29.
• [441] Rhizoma Dioscoreae Nipponicae polysaccharides protect HUVECs from H2O2-induced injury by regulating PPAR factor and the NADPH oxidase/ROS-NF-B signal pathway. Toxicol Lett. 2015 Jan 5;232(1):149-58. doi: 10.1016/j.toxlet.2014.10.006. Epub 2014 Oct 8.
• [442] The ligands/activators for peroxisome proliferator-activated receptor alpha (PPARalpha) and PPARgamma increase Cu2+,Zn2+-superoxide dismutase and decrease p22phox message expressions in primary endothelial cells. Metabolism. 2001 Jan;50(1):3-11.
• [443] Influence of glucosamine sulphate on oxidative stress in human osteoarthritic chondrocytes: effects on HO-1, p22(Phox) and iNOS expression. Rheumatology (Oxford). 2008 Jan;47(1):31-5. doi: 10.1093/rheumatology/kem289.
• [444] Role of NADPH oxidase in arsenic-induced reactive oxygen species formation and cytotoxicity in myeloid leukemia cells. Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4578-83.
• [445] Proteomic and functional analyses reveal a dual molecular mechanism underlying arsenic-induced apoptosis in human multiple myeloma cells. J Proteome Res. 2009 Jun;8(6):3006-19.
• [446] Effects of paclitaxel on proliferation and apoptosis in human acute myeloid leukemia HL-60 cells. Acta Pharmacol Sin. 2004 Mar;25(3):378-84.
• [447] Quantitative Assessment of Arsenite-Induced Perturbation of Ubiquitinated Proteome. Chem Res Toxicol. 2022 Sep 19;35(9):1589-1597. doi: 10.1021/acs.chemrestox.2c00197. Epub 2022 Aug 22.
• [448] Sumoylation of eukaryotic elongation factor 2 is vital for protein stability and anti-apoptotic activity in lung adenocarcinoma cells. Cancer Sci. 2011 Aug;102(8):1582-9. doi: 10.1111/j.1349-7006.2011.01975.x. Epub 2011 Jun 23.
• [449] Gene expression analysis using human cancer xenografts to identify novel predictive marker genes for the efficacy of 5-fluorouracil-based drugs. Cancer Sci. 2006 Jun;97(6):510-22. doi: 10.1111/j.1349-7006.2006.00204.x.
• [450] Growth inhibition of ovarian tumor-initiating cells by niclosamide. Mol Cancer Ther. 2012 Aug;11(8):1703-12.
• [451] DNA array analysis of the effects of aspirin on colon cancer cells: involvement of Rac1. Carcinogenesis. 2004 Jul;25(7):1293-8.
• [452] Morphological and molecular course of mitochondrial pathology in cultured human cells exposed long-term to Zidovudine. Environ Mol Mutagen. 2007 Apr-May;48(3-4):179-89. doi: 10.1002/em.20245.
• [453] Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens. Food Chem Toxicol. 2009 Apr;47(4):787-95.
• [454] Promotion of the articular cartilage proteoglycan degradation by T-2 toxin and selenium protective effect. J Zhejiang Univ Sci B. 2008 Jan;9(1):22-33. doi: 10.1631/jzus.B071322.
• [455] Simvastatin prevents skeletal metastasis of breast cancer by an antagonistic interplay between p53 and CD44. J Biol Chem. 2011 Apr 1;286(13):11314-27. doi: 10.1074/jbc.M110.193714. Epub 2011 Jan 3.
• [456] Enhancement of the antiproliferative activity of gemcitabine by modulation of c-Met pathway in pancreatic cancer. Curr Pharm Des. 2013;19(5):940-50.
• [457] The antipsychotic chlorpromazine suppresses YAP signaling, stemness properties, and drug resistance in breast cancer cells. Chem Biol Interact. 2019 Apr 1;302:28-35. doi: 10.1016/j.cbi.2019.01.033. Epub 2019 Jan 28.
• [458] G-protein gene 825C>T polymorphism is associated with response to clozapine in Brazilian schizophrenics. Pharmacogenomics. 2008 Oct;9(10):1429-36. doi: 10.2217/14622416.9.10.1429.
• [459] Age-dependent antidepressant pharmacogenomics: polymorphisms of the serotonin transporter and G protein beta3 subunit as predictors of response to fluoxetine and nortriptyline. Int J Neuropsychopharmacol. 2003 Dec;6(4):339-46. doi: 10.1017/S1461145703003663.
• [460] Weight loss and body fat reduction under sibutramine therapy in obesity with the C825T polymorphism in the GNB3 gene. Pharmacogenet Genomics. 2009 Sep;19(9):730-3. doi: 10.1097/FPC.0b013e3283307cf1.
• [461] G protein beta3 polymorphism and triptan response in cluster headache. Clin Pharmacol Ther. 2007 Oct;82(4):396-401. doi: 10.1038/sj.clpt.6100159. Epub 2007 Mar 14.
• [462] Efficacy of oral sildenafil in a beraprost-treated patient with severe pulmonary hypertension secondary to type I glycogen storage disease. Circ J. 2009 Oct;73(10):1965-8. doi: 10.1253/circj.cj-08-0181. Epub 2009 Jan 27.
• [463] Cardiac toxicity of high-dose cyclophosphamide in patients with multiple myeloma undergoing autologous hematopoietic stem cell transplantation. Int J Hematol. 2007 Jun;85(5):408-14. doi: 10.1532/IJH97.E0620.
• [464] Possible association of heart failure status with synthetic balance between aldosterone and dehydroepiandrosterone in human heart. Circulation. 2004 Sep 28;110(13):1787-93. doi: 10.1161/01.CIR.0000143072.36782.51. Epub 2004 Sep 13.
• [465] Docetaxel induced cardiotoxicity. Heart. 2001 Aug;86(2):219. doi: 10.1136/heart.86.2.219.
• [466] Cardiac toxicity from ethanol exposure in human-induced pluripotent stem cell-derived cardiomyocytes. Toxicol Sci. 2019 May 1;169(1):280-292.
• [467] DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia. Blood. 2016 Aug 18;128(7):971-81. doi: 10.1182/blood-2015-11-684225. Epub 2016 Jun 22.
• [468] Selenium is critical for cancer-signaling gene expression but not cell proliferation in human colon Caco-2 cells. Biofactors. 2007;31(3-4):155-64. doi: 10.1002/biof.5520310302.
• [469] Quercetin regulates insulin like growth factor signaling and induces intrinsic and extrinsic pathway mediated apoptosis in androgen independent prostate cancer cells (PC-3). Mol Cell Biochem. 2010 Nov;344(1-2):173-84. doi: 10.1007/s11010-010-0540-4. Epub 2010 Jul 25.
• [470] Curcumin reduces the expression of survivin, leading to enhancement of arsenic trioxide-induced apoptosis in myelodysplastic syndrome and leukemia stem-like cells. Oncol Rep. 2016 Sep;36(3):1233-42. doi: 10.3892/or.2016.4944. Epub 2016 Jul 15.
• [471] DHT and testosterone, but not DHEA or E2, differentially modulate IGF-I, IGFBP-2, and IGFBP-3 in human prostatic stromal cells. Am J Physiol Endocrinol Metab. 2006 May;290(5):E952-60. doi: 10.1152/ajpendo.00451.2005. Epub 2005 Dec 20.
• [472] Effects of histamine H(2)-receptor antagonists on human plasma levels of calcitonin gene-related peptide, substance P and vasoactive intestinal peptide. J Pharm Pharmacol. 2002 Nov;54(11):1559-63. doi: 10.1211/002235702117.
• [473] Analgesic action of acetaminophen in symptomatic osteoarthritis of the knee. Rheumatology (Oxford). 2006 Jun;45(6):765-70. doi: 10.1093/rheumatology/kei253. Epub 2006 Jan 31.
• [474] Down-regulation of amygdala preprotachykinin A mRNA but not 3H-SP receptor binding sites in subjects affected by mood disorders and schizophrenia. Eur J Neurosci. 2005 Mar;21(6):1712-8. doi: 10.1111/j.1460-9568.2005.04002.x.
• [475] Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures. Exp Dermatol. 2004 Mar;13(3):129-39. doi: 10.1111/j.0906-6705.2004.0178.x.
• [476] Aberrantly expressed genes in HaCaT keratinocytes chronically exposed to arsenic trioxide. Biomark Insights. 2011 Feb 8;6:7-16.
• [477] Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
• [478] RNA sequence analysis of inducible pluripotent stem cell-derived cardiomyocytes reveals altered expression of DNA damage and cell cycle genes in response to doxorubicin. Toxicol Appl Pharmacol. 2018 Oct 1;356:44-53.
• [479] Differential expression of microRNAs and their predicted targets in renal cells exposed to amphotericin B and its complex with copper (II) ions. Toxicol Mech Methods. 2017 Sep;27(7):537-543. doi: 10.1080/15376516.2017.1333554. Epub 2017 Jun 8.
• [480] Cannabinoid receptor type I modulates alcohol-induced liver fibrosis. Mol Med. 2011;17(11-12):1285-94. doi: 10.2119/molmed.2011.00149. Epub 2011 Aug 19.
• [481] Cannabinoid Type 1 Receptors Are Upregulated During Acute Activation of Brown Adipose Tissue. Diabetes. 2018 Jul;67(7):1226-1236. doi: 10.2337/db17-1366. Epub 2018 Apr 12.
• [482] Regulation of opioid and cannabinoid receptor genes in human neuroblastoma and T cells by the epigenetic modifiers trichostatin A and 5-aza-2'-deoxycytidine. Neuroimmunomodulation. 2012;19(3):180-6. doi: 10.1159/000331474. Epub 2012 Jan 18.
• [483] Human embryonic stem cell derived hepatocyte-like cells as a tool for in vitro hazard assessment of chemical carcinogenicity. Toxicol Sci. 2011 Dec;124(2):278-90. doi: 10.1093/toxsci/kfr225. Epub 2011 Aug 27.
• [484] Mapping the dynamics of Nrf2 antioxidant and NFB inflammatory responses by soft electrophilic chemicals in human liver cells defines the transition from adaptive to adverse responses. Toxicol In Vitro. 2022 Oct;84:105419. doi: 10.1016/j.tiv.2022.105419. Epub 2022 Jun 17.
• [485] Classification of heavy-metal toxicity by human DNA microarray analysis. Environ Sci Technol. 2007 May 15;41(10):3769-74.
• [486] The hepatotoxic fluoroquinolone trovafloxacin disturbs TNF- and LPS-induced p65 nuclear translocation in vivo and in vitro. Toxicol Appl Pharmacol. 2020 Mar 15;391:114915. doi: 10.1016/j.taap.2020.114915. Epub 2020 Feb 6.
• [487] NOTCH signaling is activated in and contributes to resistance in enzalutamide-resistant prostate cancer cells. J Biol Chem. 2019 May 24;294(21):8543-8554. doi: 10.1074/jbc.RA118.006983. Epub 2019 Apr 2.
• [488] Tumor necrosis factor-alpha-induced protein 3 as a putative regulator of nuclear factor-kappaB-mediated resistance to O6-alkylating agents in human glioblastomas. J Clin Oncol. 2006 Jan 10;24(2):274-87. doi: 10.1200/JCO.2005.02.9405. Epub 2005 Dec 19.
• [489] Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
• [490] Pharmacogenomic identification of novel determinants of response to chemotherapy in colon cancer. Cancer Res. 2006 Mar 1;66(5):2765-77.
• [491] Comparison of the global gene expression profiles produced by methylparaben, n-butylparaben and 17beta-oestradiol in MCF7 human breast cancer cells. J Appl Toxicol. 2007 Jan-Feb;27(1):67-77. doi: 10.1002/jat.1200.
• [492] Synergistic effects of arsenic trioxide combined with ascorbic acid in human osteosarcoma MG-63 cells: a systems biology analysis. Eur Rev Med Pharmacol Sci. 2014;18(24):3877-88.
• [493] Effect of nephrotoxicants and hepatotoxicants on gene expression profile in human peripheral blood mononuclear cells. Biochem Biophys Res Commun. 2010 Oct 15;401(2):245-50. doi: 10.1016/j.bbrc.2010.09.039. Epub 2010 Sep 16.
• [494] Exposure-based assessment of chemical teratogenicity using morphogenetic aggregates of human embryonic stem cells. Reprod Toxicol. 2020 Jan;91:74-91. doi: 10.1016/j.reprotox.2019.10.004. Epub 2019 Nov 8.
• [495] hiPSC-Based Model of Prenatal Exposure to Cannabinoids: Effect on Neuronal Differentiation. Front Mol Neurosci. 2020 Jul 6;13:119. doi: 10.3389/fnmol.2020.00119. eCollection 2020.
• [496] Epigenetic changes and disturbed neural development in a human embryonic stem cell-based model relating to the fetal valproate syndrome. Hum Mol Genet. 2012 Sep 15;21(18):4104-14. doi: 10.1093/hmg/dds239. Epub 2012 Jun 20.
• [497] Lunasin, a novel seed peptide, sensitizes human breast cancer MDA-MB-231 cells to aspirin-arrested cell cycle and induced apoptosis. Chem Biol Interact. 2010 Jul 30;186(2):127-34. doi: 10.1016/j.cbi.2010.04.027. Epub 2010 May 21.
• [498] Inorganic arsenic exposure promotes malignant progression by HDAC6-mediated down-regulation of HTRA1. J Appl Toxicol. 2023 Aug;43(8):1214-1224. doi: 10.1002/jat.4457. Epub 2023 Mar 11.
• [499] Cellular reactions to long-term volatile organic compound (VOC) exposures. Sci Rep. 2016 Dec 1;6:37842. doi: 10.1038/srep37842.
• [500] NO-sulindac inhibits the hypoxia response of PC-3 prostate cancer cells via the Akt signalling pathway. Int J Cancer. 2009 Jan 1;124(1):223-32. doi: 10.1002/ijc.23934.
• [501] Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
• [502] Dissecting progressive stages of 5-fluorouracil resistance in vitro using RNA expression profiling. Int J Cancer. 2004 Nov 1;112(2):200-12. doi: 10.1002/ijc.20401.
• [503] Cellular retinoic acid binding protein I: expression and functional influence in renal cell carcinoma. Tumour Biol. 2005 Nov-Dec;26(6):313-23. doi: 10.1159/000089262. Epub 2005 Oct 25.
• [504] [Effect of inhibiting aquaporin-1 on proliferation and apoptosis of the Hep-2 cell]. Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2006 Nov;20(21):988-91.
• [505] Inorganic arsenic as an endocrine disruptor: modulation of the glucocorticoid receptor pathway in placental cells via CpG methylation. Chem Res Toxicol. 2019 Mar 18;32(3):493-499.
• [506] Pregnancy exposure to synthetic phenols and placental DNA methylation - An epigenome-wide association study in male infants from the EDEN cohort. Environ Pollut. 2021 Dec 1;290:118024. doi: 10.1016/j.envpol.2021.118024. Epub 2021 Aug 21.
• [507] Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Cancer Res. 2006 Jun 1;66(11):5542-8. doi: 10.1158/0008-5472.CAN-05-4620.
• [508] Involvement of the p38 MAPK signaling pathway in S-phase cell-cycle arrest induced by Furazolidone in human hepatoma G2 cells. J Appl Toxicol. 2013 Dec;33(12):1500-5. doi: 10.1002/jat.2829. Epub 2012 Oct 30.
• [509] Thiazolidinediones inhibit proliferation of microvascular and macrovascular cells by a PPARgamma-independent mechanism. Diabetologia. 2005 Mar;48(3):586-94. doi: 10.1007/s00125-005-1672-z. Epub 2005 Feb 24.
• [510] Retinoid targeting of different D-type cyclins through distinct chemopreventive mechanisms. Cancer Res. 2005 Jul 15;65(14):6476-83. doi: 10.1158/0008-5472.CAN-05-0370.
• [511] Effects of chlorpromazine with and without UV irradiation on gene expression of HepG2 cells. Mutat Res. 2005 Aug 4;575(1-2):47-60. doi: 10.1016/j.mrfmmm.2005.03.002. Epub 2005 Apr 26.
• [512] The human receptor tyrosine kinase Axl gene--promoter characterization and regulation of constitutive expression by Sp1, Sp3 and CpG methylation. Biosci Rep. 2008 Jun;28(3):161-76. doi: 10.1042/BSR20080046.
• [513] Non-canonical Opioid Signaling Inhibits Itch Transmission in the Spinal Cord of Mice. Cell Rep. 2018 Apr 17;23(3):866-877. doi: 10.1016/j.celrep.2018.03.087.
• [514] Chemical stresses fail to mimic the unfolded protein response resulting from luminal load with unfolded polypeptides. J Biol Chem. 2018 Apr 13;293(15):5600-5612.
• [515] Transcriptome dynamics of alternative splicing events revealed early phase of apoptosis induced by methylparaben in H1299 human lung carcinoma cells. Arch Toxicol. 2020 Jan;94(1):127-140. doi: 10.1007/s00204-019-02629-w. Epub 2019 Nov 20.
• [516] Novel functional view of the crocidolite asbestos-treated A549 human lung epithelial transcriptome reveals an intricate network of pathways with opposing functions. BMC Genomics. 2008 Aug 7;9:376.
• [517] Gene expression in human hippocampus from cocaine abusers identifies genes which regulate extracellular matrix remodeling. PLoS One. 2007 Nov 14;2(11):e1187. doi: 10.1371/journal.pone.0001187.
• [518] Bisphenol-A and estradiol exert novel gene regulation in human MCF-7 derived breast cancer cells. Mol Cell Endocrinol. 2004 Jun 30;221(1-2):47-55. doi: 10.1016/j.mce.2004.04.010.
• [519] Copper-transporting P-type adenosine triphosphatase (ATP7B) is associated with cisplatin resistance. Cancer Res. 2000 Mar 1;60(5):1312-6.
• [520] The loop connecting metal-binding domains 3 and 4 of ATP7B is a target of a kinase-mediated phosphorylation. Biochemistry. 2009 Jun 23;48(24):5573-81. doi: 10.1021/bi900325k.
• [521] Capsaicin promotes a more aggressive gene expression phenotype and invasiveness in null-TRPV1 urothelial cancer cells. Carcinogenesis. 2011 May;32(5):686-94. doi: 10.1093/carcin/bgr025. Epub 2011 Feb 10.
• [522] Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics. Sci Rep. 2023 Jun 29;13(1):10519. doi: 10.1038/s41598-023-37488-0.
• [523] PLX4032 Mediated Melanoma Associated Antigen Potentiation in Patient Derived Primary Melanoma Cells. J Cancer. 2015 Oct 29;6(12):1320-30. doi: 10.7150/jca.11126. eCollection 2015.
• [524] Comparative proteomics reveals concordant and discordant biochemical effects of caffeine versus epigallocatechin-3-gallate in human endothelial cells. Toxicol Appl Pharmacol. 2019 Sep 1;378:114621. doi: 10.1016/j.taap.2019.114621. Epub 2019 Jun 10.
• [525] Reduced camptothecin sensitivity of estrogen receptor-positive human breast cancer cells following exposure to di(2-ethylhexyl)phthalate (DEHP) is associated with DNA methylation changes. Environ Toxicol. 2019 Apr;34(4):401-414.
• [526] THC Treatment Alters Glutamate Receptor Gene Expression in Human Stem Cell-Derived Neurons. Mol Neuropsychiatry. 2017 Nov;3(2):73-84. doi: 10.1159/000477762. Epub 2017 Jul 20.
• [527] Cocaine-induced alterations in nucleus accumbens ionotropic glutamate receptor subunits in human and non-human primates. J Neurochem. 2005 Dec;95(6):1785-93. doi: 10.1111/j.1471-4159.2005.03517.x.
• [528] Disruption of glutamate neurotransmitter transmission is modulated by SNAP-25 in benzo[a]pyrene-induced neurotoxic effects. Toxicology. 2017 Jun 1;384:11-22. doi: 10.1016/j.tox.2017.03.021. Epub 2017 Apr 19.
• [529] Epigenetic siRNA and chemical screens identify SETD8 inhibition as a therapeutic strategy for p53 activation in high-risk neuroblastoma. Cancer Cell. 2017 Jan 9;31(1):50-63.
• [530] Inhibition of cardiomyocyte differentiation of human induced pluripotent stem cells by Ribavirin: Implication for its cardiac developmental toxicity. Toxicology. 2020 Apr 15;435:152422. doi: 10.1016/j.tox.2020.152422. Epub 2020 Feb 26.
• [531] Multicenter prospective investigation on cardiovascular adverse effects of tacrolimus in kidney transplantations. Cardiovasc Drugs Ther. 2003 Mar;17(2):141-9. doi: 10.1023/a:1025339819051.
• [532] A novel long noncoding RNA AK001796 acts as an oncogene and is involved in cell growth inhibition by resveratrol in lung cancer. Toxicol Appl Pharmacol. 2015 Jun 1;285(2):79-88.
• [533] Identification of genes linked to gefitinib treatment in prostate cancer cell lines with or without resistance to androgen: a clue to application of gefitinib to hormone-resistant prostate cancer. Oncol Rep. 2006 Jun;15(6):1453-60.
• [534] [Quercetin affects leptin and its receptor in human gastric cancer MGC-803 cells and JAK-STAT pathway]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2012 Jan;28(1):12-6.
• [535] Regulation of leptin receptor expression in human papillary thyroid cancer cells. Biomed Pharmacother. 2012 Sep;66(6):469-73. doi: 10.1016/j.biopha.2012.03.008. Epub 2012 Mar 31.
• [536] Lipoxin A4 methyl ester attenuated ketamine-induced neurotoxicity in SH-SY5Y cells via regulating leptin pathway. Toxicol In Vitro. 2023 Jun;89:105581. doi: 10.1016/j.tiv.2023.105581. Epub 2023 Mar 11.
• [537] Quercetin in elimination of tumor initiating stem-like and mesenchymal transformation property in head and neck cancer. Head Neck. 2013 Mar;35(3):413-9. doi: 10.1002/hed.22982. Epub 2012 Mar 16.
• [538] Integrated analysis of rifampicin-induced microRNA and gene expression changes in human hepatocytes. Drug Metab Pharmacokinet. 2014;29(4):333-40.
• [539] Glucosamine-induced endoplasmic reticulum dysfunction is associated with accelerated atherosclerosis in a hyperglycemic mouse model. Diabetes. 2006 Jan;55(1):93-101.
• [540] Gene expression profile induced by arsenic trioxide in chronic lymphocytic leukemia cells reveals a central role for heme oxygenase-1 in apoptosis and regulation of matrix metalloproteinase-9. Oncotarget. 2016 Dec 13;7(50):83359-83377.
• [541] Inactivation of RASSF2A by promoter methylation correlates with lymph node metastasis in nasopharyngeal carcinoma. Int J Cancer. 2007 Jan 1;120(1):32-8. doi: 10.1002/ijc.22185.
• [542] Casodex treatment induces hypoxia-related gene expression in the LNCaP prostate cancer progression model. BMC Urol. 2005 Mar 24;5:5.
• [543] Effect of ovarian steroids on gene expression profile in human uterine microvascular endothelial cells. Fertil Steril. 2009 Aug;92(2):709-21.
• [544] Transcriptional profiling in the human prefrontal cortex: evidence for two activational states associated with cocaine abuse. Pharmacogenomics J. 2003;3(1):27-40.
• [545] Global expression profiling of theophylline response genes in macrophages: evidence of airway anti-inflammatory regulation. Respir Res. 2005 Aug 8;6(1):89. doi: 10.1186/1465-9921-6-89.
• [546] Proteomics and disease network associations evaluation of environmentally relevant Bisphenol A concentrations in a human 3D neural stem cell model. Front Cell Dev Biol. 2023 Aug 16;11:1236243. doi: 10.3389/fcell.2023.1236243. eCollection 2023.
• [547] Identification of novel low-dose bisphenol a targets in human foreskin fibroblast cells derived from hypospadias patients. PLoS One. 2012;7(5):e36711. doi: 10.1371/journal.pone.0036711. Epub 2012 May 4.
• [548] Pharmacogenomic analysis of acute promyelocytic leukemia cells highlights CYP26 cytochrome metabolism in differential all-trans retinoic acid sensitivity. Blood. 2007 May 15;109(10):4450-60.
• [549] Arsenic-induced sumoylation of Mus81 is involved in regulating genomic stability. Cell Cycle. 2017 Apr 18;16(8):802-811. doi: 10.1080/15384101.2017.1302628. Epub 2017 Mar 20.
• [550] Gene expression changes associated with altered growth and differentiation in benzo[a]pyrene or arsenic exposed normal human epidermal keratinocytes. J Appl Toxicol. 2008 May;28(4):491-508.
• [551] Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes. Toxicol Lett. 2018 Jun 1;289:1-13.
• [552] Proteomic analysis of hepatic effects of phenobarbital in mice with humanized liver. Arch Toxicol. 2022 Oct;96(10):2739-2754. doi: 10.1007/s00204-022-03338-7. Epub 2022 Jul 26.
• [553] Endometrial receptivity is affected in women with high circulating progesterone levels at the end of the follicular phase: a functional genomics analysis. Hum Reprod. 2011 Jul;26(7):1813-25.
• [554] Effects of residual levels of tetracycline on the barrier functions of human intestinal epithelial cells. Food Chem Toxicol. 2017 Nov;109(Pt 1):253-263. doi: 10.1016/j.fct.2017.09.004. Epub 2017 Sep 4.
• [555] ON 01910.Na is selectively cytotoxic for chronic lymphocytic leukemia cells through a dual mechanism of action involving PI3K/AKT inhibition and induction of oxidative stress. Clin Cancer Res. 2012 Apr 1;18(7):1979-91. doi: 10.1158/1078-0432.CCR-11-2113. Epub 2012 Feb 20.
• [556] Detection of gene expression alteration of myeloma cells treated with arsenic trioxide. Zhonghua Xue Ye Xue Za Zhi. 2005 Apr;26(4):209-13.
• [557] Progesterone regulation of implantation-related genes: new insights into the role of oestrogen. Cell Mol Life Sci. 2007 Apr;64(7-8):1009-32.
• [558] The effect of estrogen compounds on human embryoid bodies. Reprod Sci. 2013 Jun;20(6):661-9. doi: 10.1177/1933719112462630. Epub 2012 Nov 26.
• [559] Methamphetamine alters the normal progression by inducing cell cycle arrest in astrocytes. PLoS One. 2014 Oct 7;9(10):e109603.
• [560] Aldosterone augments LOX-1-mediated low-density lipoprotein uptake in human umbilical artery endothelial cells. Pharmacol Rep. 2010 Mar-Apr;62(2):311-8. doi: 10.1016/s1734-1140(10)70271-1.
• [561] PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells. J Exp Med. 2006 Oct 2;203(10):2351-62.
• [562] Nifedipine prevents apoptosis of endothelial cells induced by oxidized low-density lipoproteins. J Cardiovasc Pharmacol. 2002 Jul;40(1):146-52. doi: 10.1097/00005344-200207000-00018.
• [563] DNA methyltransferase inhibitors coordinately induce expression of the human reelin and glutamic acid decarboxylase 67 genes. Mol Pharmacol. 2007 Mar;71(3):644-53. doi: 10.1124/mol.106.030635. Epub 2006 Oct 25.
• [564] Inter-laboratory comparison of human renal proximal tubule (HK-2) transcriptome alterations due to Cyclosporine A exposure and medium exhaustion. Toxicol In Vitro. 2009 Apr;23(3):486-99.
• [565] Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells. Arch Toxicol. 2018 Apr;92(4):1507-1524.
• [566] The effect of zinc and D-penicillamine in a stable human hepatoma ATP7B knockout cell line. PLoS One. 2014 Jun 3;9(6):e98809. doi: 10.1371/journal.pone.0098809. eCollection 2014.
• [567] Effects of aromatase inhibitors on human osteoblast and osteoblast-like cells: a possible androgenic bone protective effects induced by exemestane. Bone. 2007 Apr;40(4):876-87. doi: 10.1016/j.bone.2006.11.029. Epub 2006 Dec 28.
• [568] Differentiation of human adipose-derived stem cells towards cardiomyocytes is facilitated by laminin. Cell Tissue Res. 2008 Dec;334(3):457-67. doi: 10.1007/s00441-008-0713-6. Epub 2008 Nov 7.
• [569] Key role of myosin light chain (MLC) kinase-mediated MLC2a phosphorylation in the alpha 1-adrenergic positive inotropic effect in human atrium. Cardiovasc Res. 2005 Jan 1;65(1):211-20. doi: 10.1016/j.cardiores.2004.09.019.
• [570] Decitabine up-regulates S100A2 expression and synergizes with IFN-gamma to kill uveal melanoma cells. Clin Cancer Res. 2007 Sep 1;13(17):5219-25. doi: 10.1158/1078-0432.CCR-07-0816.
• [571] Role of microRNAs in senescence and its contribution to peripheral neuropathy in the arsenic exposed population of West Bengal, India. Environ Pollut. 2018 Feb;233:596-603. doi: 10.1016/j.envpol.2017.09.063. Epub 2017 Nov 5.
• [572] Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury. Arch Toxicol. 2020 Apr;94(4):1151-1172. doi: 10.1007/s00204-020-02691-9. Epub 2020 Mar 10.
• [573] The sunless tanning agent dihydroxyacetone induces stress response gene expression and signaling in cultured human keratinocytes and reconstructed epidermis. Redox Biol. 2020 Sep;36:101594. doi: 10.1016/j.redox.2020.101594. Epub 2020 May 29.
• [574] Evaluation of xenobiotic N- and S-oxidation by variant flavin-containing monooxygenase 1 (FMO1) enzymes. Toxicol Sci. 2004 Apr;78(2):196-203.
• [575] A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies. PLoS Med. 2006 Dec;3(12):e486. doi: 10.1371/journal.pmed.0030486.
• [576] Gene expression changes in primary human nasal epithelial cells exposed to formaldehyde in vitro. Toxicol Lett. 2010 Oct 5;198(2):289-95.
• [577] A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system. Toxicol Sci. 2005 Feb;83(2):282-92.
• [578] In vitro detection of drug-induced phospholipidosis using gene expression and fluorescent phospholipid based methodologies. Toxicol Sci. 2007 Sep;99(1):162-73.
• [579] Differentiation of human embryonic stem cells into smooth muscle cells in adherent monolayer culture. Biochem Biophys Res Commun. 2006 Dec 15;351(2):321-7. doi: 10.1016/j.bbrc.2006.09.171. Epub 2006 Oct 17.
• [580] The Bromodomain Inhibitor JQ1 and the Histone Deacetylase Inhibitor Panobinostat Synergistically Reduce N-Myc Expression and Induce Anticancer Effects. Clin Cancer Res. 2016 May 15;22(10):2534-44. doi: 10.1158/1078-0432.CCR-15-1666. Epub 2016 Jan 5.
• [581] 1-A680T variant in GUCY1A3 as a candidate conferring protection from pulmonary hypertension among Kyrgyz highlanders. Circ Cardiovasc Genet. 2014 Dec;7(6):920-9. doi: 10.1161/CIRCGENETICS.114.000763. Epub 2014 Nov 4.
• [582] Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways. Food Chem Toxicol. 2021 Dec;158:112664. doi: 10.1016/j.fct.2021.112664. Epub 2021 Nov 9.
• [583] Atheroprotective effects of methotrexate on reverse cholesterol transport proteins and foam cell transformation in human THP-1 monocyte/macrophages. Arthritis Rheum. 2008 Dec;58(12):3675-83.
• [584] PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine. J Lipid Res. 2007 Feb;48(2):373-84.
• [585] Organochloride pesticides modulated gut microbiota and influenced bile acid metabolism in mice. Environ Pollut. 2017 Jul;226:268-276.
• [586] Effects of rosiglitazone and atorvastatin on the expression of genes that control cholesterol homeostasis in differentiating monocytes. Biochem Pharmacol. 2006 Feb 28;71(5):605-14.
• [587] Circulating endothelial progenitor cells in multiple myeloma: implications and significance. Blood. 2005 Apr 15;105(8):3286-94. doi: 10.1182/blood-2004-06-2101. Epub 2004 Dec 23.
• [588] Propranolol inhibits proliferation and induces apoptosis of hemangioma-derived endothelial cells via Akt pathway by down-regulating Ang-2 expression. Chem Biol Interact. 2020 Jan 25;316:108925. doi: 10.1016/j.cbi.2019.108925. Epub 2019 Dec 12.
• [589] Malathion induced cancer-linked gene expression in human lymphocytes. Environ Res. 2020 Mar;182:109131. doi: 10.1016/j.envres.2020.109131. Epub 2020 Jan 10.
• [590] Rigosertib as a selective anti-tumor agent can ameliorate multiple dysregulated signaling transduction pathways in high-grade myelodysplastic syndrome. Sci Rep. 2014 Dec 4;4:7310. doi: 10.1038/srep07310.
• [591] Convergent transcriptional profiles induced by endogenous estrogen and distinct xenoestrogens in breast cancer cells. Carcinogenesis. 2006 Aug;27(8):1567-78.
• [592] Ouabain impairs cell migration, and invasion and alters gene expression of human osteosarcoma U-2 OS cells. Environ Toxicol. 2017 Nov;32(11):2400-2413. doi: 10.1002/tox.22453. Epub 2017 Aug 10.
• [593] Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies. J Biol Chem. 2019 Oct 18;294(42):15218-15234. doi: 10.1074/jbc.RA119.009147. Epub 2019 Jul 8.
• [594] Histamine up-regulates phosphodiesterase 4 activity and reduces prostaglandin E2-inhibitory effects in human neutrophils. Inflamm Res. 2000 Nov;49(11):600-9. doi: 10.1007/s000110050637.
• [595] Analysis of estrogen agonism and antagonism of tamoxifen, raloxifene, and ICI182780 in endometrial cancer cells: a putative role for the epidermal growth factor receptor ligand amphiregulin. J Soc Gynecol Investig. 2005 Oct;12(7):e55-67.
• [596] Antineoplastic effects of gamma linolenic Acid on hepatocellular carcinoma cell lines. J Clin Biochem Nutr. 2010 Jul;47(1):81-90.
• [597] Peroxisome proliferator activated receptor gamma (PPAR-gama) ligand pioglitazone regulated gene networks in term human primary trophoblast cells. Reprod Toxicol. 2018 Oct;81:99-107.
• [598] Prediction of the contact sensitizing potential of chemicals using analysis of gene expression changes in human THP-1 monocytes. Toxicol Lett. 2010 Nov 10;199(1):51-9.
• [599] BET bromodomain inhibition of MYC-amplified medulloblastoma. Clin Cancer Res. 2014 Feb 15;20(4):912-25.
• [600] White-to-brown metabolic conversion of human adipocytes by JAK inhibition. Nat Cell Biol. 2015 Jan;17(1):57-67. doi: 10.1038/ncb3075. Epub 2014 Dec 8.
• [601] Epidermal growth factor receptor signalling in human breast cancer cells operates parallel to estrogen receptor alpha signalling and results in tamoxifen insensitive proliferation. BMC Cancer. 2014 Apr 23;14:283.
• [602] A genomic approach to predict synergistic combinations for breast cancer treatment. Pharmacogenomics J. 2013 Feb;13(1):94-104. doi: 10.1038/tpj.2011.48. Epub 2011 Nov 15.
• [603] Dose- and time-dependent effects of phenobarbital on gene expression profiling in human hepatoma HepaRG cells. Toxicol Appl Pharmacol. 2009 Feb 1;234(3):345-60.
• [604] Genome-wide transcriptional and functional analysis of human T lymphocytes treated with benzo[alpha]pyrene. Int J Mol Sci. 2018 Nov 17;19(11).
• [605] 5-Aza-2'-deoxycytidine-mediated reductions in G9A histone methyltransferase and histone H3 K9 di-methylation levels are linked to tumor suppressor gene reactivation. Oncogene. 2007 Jan 4;26(1):77-90. doi: 10.1038/sj.onc.1209763. Epub 2006 Jun 26.
• [606] Expression and DNA methylation changes in human breast epithelial cells after bisphenol A exposure. Int J Oncol. 2012 Jul;41(1):369-77.
• [607] Proteomic analysis of antiproliferative effects by treatment of 5-fluorouracil in cervical cancer cells. DNA Cell Biol. 2004 Nov;23(11):769-76.
• [608] Targetome analysis of chaperone-mediated autophagy in cancer cells. Autophagy. 2019 Sep;15(9):1558-1571. doi: 10.1080/15548627.2019.1586255. Epub 2019 Mar 20.
• [609] Transcriptomic analysis of human primary bronchial epithelial cells after chloropicrin treatment. Chem Res Toxicol. 2015 Oct 19;28(10):1926-35.
• [610] Low-dose Bisphenol A exposure alters the functionality and cellular environment in a human cardiomyocyte model. Environ Pollut. 2023 Oct 15;335:122359. doi: 10.1016/j.envpol.2023.122359. Epub 2023 Aug 9.
• [611] Gene expression levels in normal human lymphoblasts with variable sensitivities to arsenite: identification of GGT1 and NFKBIE expression levels as possible biomarkers of susceptibility. Toxicol Appl Pharmacol. 2008 Jan 15;226(2):199-205. doi: 10.1016/j.taap.2007.09.004. Epub 2007 Sep 15.
• [612] Simvastatin modulates the Alzheimer's disease-related gene seladin-1. J Alzheimers Dis. 2012;28(2):297-301.
• [613] Comparative effects of DHEA and DHT on gene expression in human LNCaP prostate cancer cells. Anticancer Res. 2006 Sep-Oct;26(5A):3205-15.
• [614] Molecular mechanisms of quercitrin-induced apoptosis in non-small cell lung cancer. Arch Med Res. 2014 Aug;45(6):445-54.
• [615] Comprehensive transcriptome profiling of BET inhibitor-treated HepG2 cells. PLoS One. 2022 Apr 29;17(4):e0266966. doi: 10.1371/journal.pone.0266966. eCollection 2022.
• [616] Resveratrol induces apoptosis and alters gene expression in human fibrosarcoma cells. Anticancer Res. 2015 Feb;35(2):767-74.
• [617] A genetic network model of cellular responses to lithium treatment and cocaine abuse in bipolar disorder. BMC Syst Biol. 2010 Nov 19;4:158. doi: 10.1186/1752-0509-4-158.
• [618] Differential regulation of native estrogen receptor-regulatory elements by estradiol, tamoxifen, and raloxifene. Mol Endocrinol. 2008 Feb;22(2):287-303. doi: 10.1210/me.2007-0340. Epub 2007 Oct 25.
• [619] A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury. Nat Genet. 2010 Aug;42(8):711-4. doi: 10.1038/ng.632. Epub 2010 Jul 18.
• [620] Transcriptomics and methylomics of CD4-positive T cells in arsenic-exposed women. Arch Toxicol. 2017 May;91(5):2067-2078. doi: 10.1007/s00204-016-1879-4. Epub 2016 Nov 12.
• [621] Induction of class II major histocompatibility complex expression in human multiple myeloma cells by retinoid. Haematologica. 2007 Jan;92(1):115-20.
• [622] Functional cardiotoxicity assessment of cosmetic compounds using human-induced pluripotent stem cell-derived cardiomyocytes. Arch Toxicol. 2018 Jan;92(1):371-381.
• [623] Anti-oncogenic and pro-differentiation effects of clorgyline, a monoamine oxidase A inhibitor, on high grade prostate cancer cells. BMC Med Genomics. 2009 Aug 20;2:55. doi: 10.1186/1755-8794-2-55.
• [624] Drinking-water arsenic exposure modulates gene expression in human lymphocytes from a U.S. population. Environ Health Perspect. 2008 Apr;116(4):524-31. doi: 10.1289/ehp.10861.
• [625] Arsenic trioxide inhibits Hedgehog, Notch and stem cell properties in glioblastoma neurospheres. Acta Neuropathol Commun. 2014 Mar 31;2:31. doi: 10.1186/2051-5960-2-31.
• [626] Genome-wide pharmacogenomic study of citalopram-induced side effects in STAR*D. Transl Psychiatry. 2012 Jul 3;2(7):e129. doi: 10.1038/tp.2012.57.
• [627] Exome-wide mutation profile in benzo[a]pyrene-derived post-stasis and immortal human mammary epithelial cells. Mutat Res Genet Toxicol Environ Mutagen. 2014 Dec;775-776:48-54. doi: 10.1016/j.mrgentox.2014.10.011. Epub 2014 Nov 4.
• [628] Polymerase I and transcript release factor (PTRF)/cavin-1 is a novel regulator of stress-induced premature senescence. J Biol Chem. 2011 Aug 19;286(33):28657-28661. doi: 10.1074/jbc.C111.235119. Epub 2011 Jun 24.
• [629] BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell. 2011 Sep 16;146(6):904-17.
• [630] DNA methylation inhibits p53-mediated survivin repression. Oncogene. 2009 May 14;28(19):2046-50. doi: 10.1038/onc.2009.62. Epub 2009 Apr 13.
• [631] Isobaric tags for relative and absolute quantitation-based proteomics analysis of the effect of ginger oil on bisphenol A-induced breast cancer cell proliferation. Oncol Lett. 2021 Feb;21(2):101. doi: 10.3892/ol.2020.12362. Epub 2020 Dec 8.
• [632] Vitamin K promotes mineralization, osteoblast-to-osteocyte transition, and an anticatabolic phenotype by {gamma}-carboxylation-dependent and -independent mechanisms. Am J Physiol Cell Physiol. 2009 Dec;297(6):C1358-67. doi: 10.1152/ajpcell.00216.2009. Epub 2009 Aug 12.
• [633] Cyclooxygenase-2 inhibition: effects on tumour growth, cell cycling and lymphangiogenesis in a xenograft model of breast cancer. Br J Cancer. 2007 Feb 26;96(4):575-82. doi: 10.1038/sj.bjc.6603593. Epub 2007 Feb 6.
• [634] Microarray-based detection and expression analysis of extracellular matrix proteins in drug?resistant ovarian cancer cell lines. Oncol Rep. 2014 Nov;32(5):1981-90. doi: 10.3892/or.2014.3468. Epub 2014 Sep 9.
• [635] Mitochondrial proteomics investigation of a cellular model of impaired dopamine homeostasis, an early step in Parkinson's disease pathogenesis. Mol Biosyst. 2014 Jun;10(6):1332-44.
• [636] Role of all-trans retinoic acid in neurite outgrowth and axonal elongation. J Neurobiol. 2006 Jun;66(7):739-56. doi: 10.1002/neu.20241.
• [637] Bisphenol A effects on gene expression in adipocytes from children: association with metabolic disorders. J Mol Endocrinol. 2015 Jun;54(3):289-303.
• [638] Mutant p53 reactivation by PRIMA-1MET induces multiple signaling pathways converging on apoptosis. Oncogene. 2010 Mar 4;29(9):1329-38. doi: 10.1038/onc.2009.425. Epub 2009 Nov 30.
• [639] Vitamin D3 transactivates the zinc and manganese transporter SLC30A10 via the Vitamin D receptor. J Steroid Biochem Mol Biol. 2016 Oct;163:77-87.
• [640] Arsenic trioxide increases expression of secreted frizzled-related protein 1 gene and inhibits the WNT/-catenin signaling pathway in Jurkat cells. Exp Ther Med. 2017 May;13(5):2050-2055. doi: 10.3892/etm.2017.4184. Epub 2017 Mar 6.
• [641] Unique transcriptome, pathways, and networks in the human endometrial fibroblast response to progesterone in endometriosis. Biol Reprod. 2011 Apr;84(4):801-15.
• [642] Positive association between aspirin-intolerant asthma and genetic polymorphisms of FSIP1: a case-case study. BMC Pulm Med. 2010 Jun 1;10:34. doi: 10.1186/1471-2466-10-34.
• [643] SLC39A2 and FSIP1 polymorphisms as potential modifiers of arsenic-related bladder cancer. Hum Genet. 2012 Mar;131(3):453-61. doi: 10.1007/s00439-011-1090-x. Epub 2011 Sep 25.
• [644] Gene expression profiling of human primary astrocytes exposed to manganese chloride indicates selective effects on several functions of the cells. Neurotoxicology. 2007 May;28(3):478-89.
• [645] Epigenetic changes in individuals with arsenicosis. Chem Res Toxicol. 2011 Feb 18;24(2):165-7. doi: 10.1021/tx1004419. Epub 2011 Feb 4.
• [646] Differently expressed long noncoding RNAs and mRNAs in TK6 cells exposed to low dose hydroquinone. Oncotarget. 2017 Oct 4;8(56):95554-95567. doi: 10.18632/oncotarget.21481. eCollection 2017 Nov 10.
• [647] Gene induction and apoptosis in human hepatocellular carci-noma cells SMMC-7721 exposed to 5-aza-2'-deoxycytidine. Chin Med J (Engl). 2007 Sep 20;120(18):1626-31.
• [648] Interindividual variation in gene expression responses and metabolite formation in acetaminophen-exposed primary human hepatocytes. Arch Toxicol. 2016 May;90(5):1103-15. doi: 10.1007/s00204-015-1545-2. Epub 2015 Jun 24.
• [649] Gene expression in endometrial cancer cells (Ishikawa) after short time high dose exposure to progesterone. Steroids. 2008 Jan;73(1):116-28.
• [650] Nitric oxide suppresses tumor cell migration through N-Myc downstream-regulated gene-1 (NDRG1) expression: role of chelatable iron. J Biol Chem. 2011 Dec 2;286(48):41413-41424. doi: 10.1074/jbc.M111.287052. Epub 2011 Oct 5.
• [651] Differential gene expression of sulindac-treated human breast epithelial cells. Int J Oncol. 2005 Dec;27(6):1727-36.
• [652] Dermal hyaluronan is rapidly reduced by topical treatment with glucocorticoids. J Invest Dermatol. 2010 Jan;130(1):141-9. doi: 10.1038/jid.2009.210.
• [653] Epigenetic silencing of novel tumor suppressors in malignant melanoma. Cancer Res. 2006 Dec 1;66(23):11187-93. doi: 10.1158/0008-5472.CAN-06-1274.
• [654] Molecular mechanisms of action of angiopreventive anti-oxidants on endothelial cells: microarray gene expression analyses. Mutat Res. 2005 Dec 11;591(1-2):198-211.
• [655] New insights into BaP-induced toxicity: role of major metabolites in transcriptomics and contribution to hepatocarcinogenesis. Arch Toxicol. 2016 Jun;90(6):1449-58.
• [656] Comprehensive analysis of transcriptomic changes induced by low and high doses of bisphenol A in HepG2 spheroids in vitro and rat liver in vivo. Environ Res. 2019 Jun;173:124-134. doi: 10.1016/j.envres.2019.03.035. Epub 2019 Mar 18.
• [657] Characterization of the Molecular Alterations Induced by the Prolonged Exposure of Normal Colon Mucosa and Colon Cancer Cells to Low-Dose Bisphenol A. Int J Mol Sci. 2022 Oct 1;23(19):11620. doi: 10.3390/ijms231911620.
• [658] Gene expression profile analysis of gallic acid-induced cell death process. Sci Rep. 2021 Aug 18;11(1):16743. doi: 10.1038/s41598-021-96174-1.
• [659] Fulvestrant induces resistance by modulating GPER and CDK6 expression: implication of methyltransferases, deacetylases and the hSWI/SNF chromatin remodelling complex. Br J Cancer. 2013 Nov 12;109(10):2751-62. doi: 10.1038/bjc.2013.583. Epub 2013 Oct 29.
• [660] Transcriptome-based functional classifiers for direct immunotoxicity. Arch Toxicol. 2014 Mar;88(3):673-89.
• [661] Epigenetic influences of low-dose bisphenol A in primary human breast epithelial cells. Toxicol Appl Pharmacol. 2010 Oct 15;248(2):111-21.
• [662] Interactions between Oroxylin A with the solute carrier transporters and ATP-binding cassette transporters: Drug transporters profile for this flavonoid. Chem Biol Interact. 2020 Jun 1;324:109097. doi: 10.1016/j.cbi.2020.109097. Epub 2020 Apr 16.
• [663] Molecular identification and functional characterization of rat multidrug and toxin extrusion type transporter 1 as an organic cation/H+ antiporter in the kidney. Drug Metab Dispos. 2006 Nov;34(11):1868-74. doi: 10.1124/dmd.106.010876. Epub 2006 Aug 23.
• [664] Neonicotinoid pesticides poorly interact with human drug transporters. J Biochem Mol Toxicol. 2019 Oct;33(10):e22379. doi: 10.1002/jbt.22379. Epub 2019 Jul 31.
• [665] Wnt signaling pathway is epigenetically regulated by methylation of Wnt antagonists in acute myeloid leukemia. Leukemia. 2009 Sep;23(9):1658-66. doi: 10.1038/leu.2009.86. Epub 2009 Apr 23.
• [666] Characterization of DOK1, a candidate tumor suppressor gene, in epithelial ovarian cancer. Mol Oncol. 2011 Oct;5(5):438-53. doi: 10.1016/j.molonc.2011.07.003. Epub 2011 Jul 26.
• [667] Anthracycline inhibits recruitment of hypoxia-inducible transcription factors and suppresses tumor cell migration and cardiac angiogenic response in the host. J Biol Chem. 2012 Oct 12;287(42):34866-34882. doi: 10.1074/jbc.M112.374587. Epub 2012 Aug 20.
• [668] Proteomic analysis of the cellular response to a potent sensitiser unveils the dynamics of haptenation in living cells. Toxicology. 2020 Dec 1;445:152603. doi: 10.1016/j.tox.2020.152603. Epub 2020 Sep 28.
• [669] Environmental pollutant induced cellular injury is reflected in exosomes from placental explants. Placenta. 2020 Jan 1;89:42-49. doi: 10.1016/j.placenta.2019.10.008. Epub 2019 Oct 17.
• [670] Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNF-mediated hepatotoxicity. Toxicol Sci. 2014 Jul;140(1):144-59. doi: 10.1093/toxsci/kfu072. Epub 2014 Apr 20.
• [671] Gene expression profiling of breast cancer cells in response to gemcitabine: NF-kappaB pathway activation as a potential mechanism of resistance. Breast Cancer Res Treat. 2007 Apr;102(2):157-72.
• [672] Dehydroepiandrosterone Activation of G-protein-coupled Estrogen Receptor Rapidly Stimulates MicroRNA-21 Transcription in Human Hepatocellular Carcinoma Cells. J Biol Chem. 2015 Jun 19;290(25):15799-15811. doi: 10.1074/jbc.M115.641167. Epub 2015 May 11.
• [673] Prediction of the combined effects of multiple estrogenic chemicals on MCF-7 human breast cancer cells and a preliminary molecular exploration of the estrogenic proliferative effects and related gene expression. Ecotoxicol Environ Saf. 2018 Sep 30;160:1-9. doi: 10.1016/j.ecoenv.2018.05.025. Epub 2018 May 21.
• [674] Geraniol suppresses prostate cancer growth through down-regulation of E2F8. Cancer Med. 2016 Oct;5(10):2899-2908.
• [675] Gene expression profile of the nucleus accumbens of human cocaine abusers: evidence for dysregulation of myelin. J Neurochem. 2004 Mar;88(5):1211-9. doi: 10.1046/j.1471-4159.2003.02247.x.
• [676] Quantitative proteomics and transcriptomics addressing the estrogen receptor subtype-mediated effects in T47D breast cancer cells exposed to the phytoestrogen genistein. Mol Cell Proteomics. 2011 Jan;10(1):M110.002170.
• [677] Gene expression profiling identifies activating transcription factor 3 as a novel contributor to the proapoptotic effect of curcumin. Mol Cancer Ther. 2005 Feb;4(2):233-41.
• [678] TNF enhances trovafloxacin-induced in vitro hepatotoxicity by inhibiting protective autophagy. Toxicol Lett. 2021 May 15;342:73-84. doi: 10.1016/j.toxlet.2021.02.009. Epub 2021 Feb 17.
• [679] Ca2+-activated K+ channels in human leukemic Jurkat T cells. Molecular cloning, biochemical and functional characterization. J Biol Chem. 2000 Dec 22;275(51):39954-63. doi: 10.1074/jbc.M001562200.
• [680] Gene-expression profiling during curcumin-induced apoptosis reveals downregulation of CXCR4. Exp Hematol. 2007 Jan;35(1):84-95.
• [681] Cannabinoid derivatives induce cell death in pancreatic MIA PaCa-2 cells via a receptor-independent mechanism. FEBS Lett. 2006 Mar 20;580(7):1733-9.
• [682] Cell-type-specific responses to chemotherapeutics in breast cancer. Cancer Res. 2004 Jun 15;64(12):4218-26.
• [683] Role of oxidative stress in the induction of metallothionein-2A and heme oxygenase-1 gene expression by the antineoplastic agent gallium nitrate in human lymphoma cells. Free Radic Biol Med. 2008 Sep 15;45(6):763-72.
• [684] Effects of SIDT2 on the miR-25/NOX4/HuR axis and SIRT3 mRNA stability lead to ROS-mediated TNF- expression in hydroquinone-treated leukemia cells. Cell Biol Toxicol. 2023 Oct;39(5):2207-2225. doi: 10.1007/s10565-022-09705-5. Epub 2022 Mar 18.
• [685] Role of calcitriol and cortisol on human adipocyte proliferation and oxidative and inflammatory stress: a microarray study. J Nutrigenet Nutrigenomics. 2008;1(1-2):30-48. doi: 10.1159/000109873. Epub 2007 Oct 16.
• [686] Capsaicin inhibits cell proliferation by enhancing oxidative stress and apoptosis through SIRT1/NOX4 signaling pathways in HepG2 and HL-7702 cells. J Biochem Mol Toxicol. 2022 Mar;36(3):e22974. doi: 10.1002/jbt.22974. Epub 2021 Dec 23.
• [687] Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures. Arch Toxicol. 2018 Jun;92(6):1939-1952.
• [688] Hesperetin relieves cisplatin-induced acute kidney injury by mitigating oxidative stress, inflammation and apoptosis. Chem Biol Interact. 2019 Aug 1;308:269-278.
• [689] Effect of prenatal arsenic exposure on DNA methylation and leukocyte subpopulations in cord blood. Epigenetics. 2014 May;9(5):774-82. doi: 10.4161/epi.28153. Epub 2014 Feb 13.
• [690] Comparison of transcriptome expression alterations by chronic exposure to low-dose bisphenol A in different subtypes of breast cancer cells. Toxicol Appl Pharmacol. 2019 Dec 15;385:114814. doi: 10.1016/j.taap.2019.114814. Epub 2019 Nov 9.
• [691] Differential DNA methylation profile of key genes in malignant prostate epithelial cells transformed by inorganic arsenic or cadmium. Toxicol Appl Pharmacol. 2015 Aug 1;286(3):159-67.
• [692] PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies. Nature. 2014 Oct 9;514(7521):247-51.
• [693] High-throughput ectopic expression screen for tamoxifen resistance identifies an atypical kinase that blocks autophagy. Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2058-63.
• [694] Association of Arsenic Exposure with Whole Blood DNA Methylation: An Epigenome-Wide Study of Bangladeshi Adults. Environ Health Perspect. 2019 May;127(5):57011. doi: 10.1289/EHP3849. Epub 2019 May 28.
• [695] 10mM glucosamine prevents activation of proADAMTS5 (aggrecanase-2) in transfected cells by interference with post-translational modification of furin. Osteoarthritis Cartilage. 2010 Mar;18(3):455-63. doi: 10.1016/j.joca.2009.10.014. Epub 2009 Nov 4.
• [696] Arsenic alters transcriptional responses to Pseudomonas aeruginosa infection and decreases antimicrobial defense of human airway epithelial cells. Toxicol Appl Pharmacol. 2017 Sep 15;331:154-163.
• [697] Ochratoxin a lowers mRNA levels of genes encoding for key proteins of liver cell metabolism. Cancer Genomics Proteomics. 2008 Nov-Dec;5(6):319-32.
• [698] Glucosamine decreases expression of anabolic and catabolic genes in human osteoarthritic cartilage explants. Osteoarthritis Cartilage. 2006 Mar;14(3):250-7. doi: 10.1016/j.joca.2005.10.001. Epub 2005 Nov 18.
• [699] Arsenic exposure from drinking water is associated with decreased gene expression and increased DNA methylation in peripheral blood. Toxicol Appl Pharmacol. 2017 Apr 15;321:57-66. doi: 10.1016/j.taap.2017.02.019. Epub 2017 Feb 24.
• [700] Ouabain at pathological concentrations might induce damage in human vascular endothelial cells. Acta Pharmacol Sin. 2006 Feb;27(2):165-72. doi: 10.1111/j.1745-7254.2006.00244.x.
• [701] A trichostatin A expression signature identified by TempO-Seq targeted whole transcriptome profiling. PLoS One. 2017 May 25;12(5):e0178302. doi: 10.1371/journal.pone.0178302. eCollection 2017.
• [702] TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons. J Neurosci. 2008 Jun 11;28(24):6231-8.
• [703] Activation of TRPV3 by Wood Smoke Particles and Roles in Pneumotoxicity. Chem Res Toxicol. 2018 May 21;31(5):291-301. doi: 10.1021/acs.chemrestox.7b00336. Epub 2018 Apr 30.
• [704] Ca(2+) Signaling and IL-8 Secretion in Human Testicular Peritubular Cells Involve the Cation Channel TRPV2. Int J Mol Sci. 2018 Sep 19;19(9):2829. doi: 10.3390/ijms19092829.
• [705] Transcriptomic?pathway?and?benchmark dose analysis of Bisphenol A, Bisphenol S, Bisphenol F, and 3,3',5,5'-Tetrabromobisphenol A in H9 human embryonic stem cells. Toxicol In Vitro. 2021 Apr;72:105097. doi: 10.1016/j.tiv.2021.105097. Epub 2021 Jan 18.
• [706] 2', 3'-Dideoxycytidine represses thymidine kinases 1 and 2 expression in T-lymphoid cells. Life Sci. 2004 Jan 2;74(7):835-42. doi: 10.1016/j.lfs.2003.07.023.
• [707] Regulation of DR-5 protein and mitochondrial transmembrane potential by gemcitabine, a possible mechanism of gemcitabine-enhanced TRAIL-induced apoptosis. Oncol Rep. 2007 Sep;18(3):523-9.
• [708] Death receptor 5 regulation during selenium-mediated apoptosis in human prostate cancer cells. Cancer Biol Ther. 2002 May-Jun;1(3):287-90. doi: 10.4161/cbt.83.
• [709] Death receptor regulation and celecoxib-induced apoptosis in human lung cancer cells. J Natl Cancer Inst. 2004 Dec 1;96(23):1769-80. doi: 10.1093/jnci/djh322.
• [710] Characterization of DNA reactive and non-DNA reactive anticancer drugs by gene expression profiling. Mutat Res. 2007 Jun 1;619(1-2):16-29. doi: 10.1016/j.mrfmmm.2006.12.007. Epub 2007 Feb 8.
• [711] JWA, a novel signaling molecule, involved in all-trans retinoic acid induced differentiation of HL-60 cells. J Biomed Sci. 2006 May;13(3):357-71. doi: 10.1007/s11373-005-9068-0. Epub 2006 Feb 9.
• [712] [Colchicine in chronic liver disease of alcoholic etiology. Double-blind, randomized study of its effects on blood levels of plasma proteins and clinical course in patients]. Rev Assoc Med Bras (1992). 1995 May-Jun;41(3):207-12.
• [713] Antithrombotic effects of aspirin based on PLA1/A2 glycoprotein IIIa polymorphism in patients with coronary artery disease. Thromb Res. 2007;119(3):301-3. doi: 10.1016/j.thromres.2006.03.005. Epub 2006 May 3.
• [714] Specificity of increased des-gamma-carboxyprothrombin in hepatocellular carcinoma after vitamin K1 injection. J Hepatol. 1987 Aug;5(1):27-9. doi: 10.1016/s0168-8278(87)80057-0.
• [715] Haemostatic effects of supraphysiological levels of testosterone in normal men. Thromb Haemost. 1995 Aug;74(2):693-7.
• [716] Atorvastatin and quinapril inhibit blood coagulation in patients with coronary artery disease following 28 days of therapy. J Thromb Haemost. 2006 Nov;4(11):2397-404. doi: 10.1111/j.1538-7836.2006.02165.x. Epub 2006 Aug 14.
• [717] Arsenic trioxide downregulates the expression of annexin II in bone marrow cells from patients with acute myelogenous leukemia. Chin Med J (Engl). 2009 Sep 5;122(17):1969-73.
• [718] Effects of oral and transvaginal ethinyl estradiol on hemostatic factors and hepatic proteins in a randomized, crossover study. J Clin Endocrinol Metab. 2007 Jun;92(6):2074-9. doi: 10.1210/jc.2007-0026. Epub 2007 Mar 20.
• [719] Effect of clofibrate on plasma proteins including components of the hemostatic mechanism. Clin Chim Acta. 1976 Jan 2;66(1):9-17. doi: 10.1016/0009-8981(76)90366-1.
• [720] Verapamil-induced hyperprolactinemia complicated by a pituitary incidentaloma. Ann Pharmacother. 1995 Oct;29(10):999-1001. doi: 10.1177/106002809502901009.
• [721] [Impotence and gynecomastia secondary to hyperprolactinemia induced by ranitidine]. Therapie. 1994 Jul-Aug;49(4):361-2.
• [722] Differential effects of estrogen receptor antagonists on pituitary lactotroph proliferation and prolactin release. Mol Cell Endocrinol. 2005 Jul 15;239(1-2):27-36. doi: 10.1016/j.mce.2005.04.008.
• [723] Cholinergic modulation of the cerebral metabolic response to citalopram in Alzheimer's disease. Brain. 2009 Feb;132(Pt 2):392-401. doi: 10.1093/brain/awn326. Epub 2009 Jan 19.
• [724] The effect of thioridazine on prolactinoma growth in a schizophrenic man: case report. Gen Hosp Psychiatry. 1985 Oct;7(4):364-6. doi: 10.1016/0163-8343(85)90053-2.
• [725] Influence of naloxone on muscle sympathetic nerve activity, systemic and calf haemodynamics and ambulatory blood pressure after exercise in mild essential hypertension. J Hypertens. 1995 Apr;13(4):447-61.
• [726] The efficacy, safety, and tolerability of aripiprazole for the treatment of schizoaffective disorder: results from a pooled analysis of a sub-population of subjects from two randomized, double-blind, placebo-controlled, pivotal trials. J Affect Disord. 2009 May;115(1-2):18-26. doi: 10.1016/j.jad.2008.12.017. Epub 2009 Feb 23.
• [727] Serum prolactin levels among outpatients with major depressive disorder during the acute phase of treatment with fluoxetine. J Clin Psychiatry. 2006 Jun;67(6):952-7. doi: 10.4088/jcp.v67n0612.
• [728] Massive breast enlargement in a patient receiving D-penicillamine for systemic sclerosis. J Rheumatol. 1985 Oct;12(5):990-1.
• [729] Indomethacin and juglone inhibit inflammatory molecules to induce apoptosis in colon cancer cells. J Biochem Mol Toxicol. 2020 Feb;34(2):e22433. doi: 10.1002/jbt.22433. Epub 2020 Jan 9.
• [730] A cell impedance-based real-time in vitro assay to assess the toxicity of amphotericin B formulations. Toxicol Appl Pharmacol. 2017 Nov 1;334:18-23. doi: 10.1016/j.taap.2017.08.017. Epub 2017 Sep 1.
• [731] CBD Promotes Oral Ulcer Healing via Inhibiting CMPK2-Mediated Inflammasome. J Dent Res. 2022 Feb;101(2):206-215. doi: 10.1177/00220345211024528. Epub 2021 Jul 16.
• [732] Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
• [733] Anti-inflammatory effects of the GABA(B) receptor agonist baclofen in allergic contact dermatitis. Exp Dermatol. 2010 Jul 1;19(7):661-6. doi: 10.1111/j.1600-0625.2010.01076.x. Epub 2010 Feb 25.
• [734] Frankincense myrrh attenuates hepatocellular carcinoma by regulating tumor blood vessel development through multiple epidermal growth factor receptor-mediated signaling pathways. World J Gastrointest Oncol. 2022 Feb 15;14(2):450-477. doi: 10.4251/wjgo.v14.i2.450.
• [735] Sulfasalazine unveils a contact-independent HSV-TK/ganciclovir gene therapy bystander effect in malignant gliomas. Int J Oncol. 2007 Jan;30(1):283-90.
• [736] AZT-induced hypermethylation of human thymidine kinase gene in the absence of total DNA hypermethylation. FEBS Lett. 1996 Nov 4;396(2-3):323-6. doi: 10.1016/0014-5793(96)01124-6.
• [737] Fluorodeoxyuridine modulates cellular expression of the DNA base excision repair enzyme uracil-DNA glycosylase. Cancer Res. 2006 Sep 1;66(17):8829-37. doi: 10.1158/0008-5472.CAN-06-0540.
• [738] Delivery method, target gene structure, and growth properties of target cells impact mutagenic responses to reactive nitrogen and oxygen species. Chem Res Toxicol. 2012 Apr 16;25(4):873-83. doi: 10.1021/tx2004882. Epub 2012 Feb 21.
• [739] Development of an integrated assay in human TK6 cells to permit comprehensive genotoxicity analysis in vitro. Mutat Res Genet Toxicol Environ Mutagen. 2020 Jan;849:503129. doi: 10.1016/j.mrgentox.2019.503129. Epub 2019 Dec 27.
• [740] E2F1 downregulation by arsenic trioxide in lung adenocarcinoma. Int J Oncol. 2014 Nov;45(5):2033-43. doi: 10.3892/ijo.2014.2609. Epub 2014 Aug 19.
• [741] Response rate of fibrosarcoma cells to cytotoxic drugs on the expression level correlates to the therapeutic response rate of fibrosarcomas and is mediated by regulation of apoptotic pathways. BMC Cancer. 2005 Jul 7;5:74. doi: 10.1186/1471-2407-5-74.
• [742] Consequences of the natural retinoid/retinoid X receptor ligands action in human breast cancer MDA-MB-231 cell line: Focus on functional proteomics. Toxicol Lett. 2017 Nov 5;281:26-34. doi: 10.1016/j.toxlet.2017.09.001. Epub 2017 Sep 5.
• [743] Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21.
• [744] Mechanisms of dexamethasone-induced disturbed sleep and fatigue in paediatric patients receiving treatment for ALL. Eur J Cancer. 2010 Jul;46(10):1848-55. doi: 10.1016/j.ejca.2010.03.026. Epub 2010 Apr 17.
• [745] Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x. Epub 2009 Apr 8.
• [746] Some HIV antiretrovirals increase oxidative stress and alter chemokine, cytokine or adiponectin production in human adipocytes and macrophages. Antivir Ther. 2007;12(4):489-500.
• [747] ERE-independent ERalpha target genes differentially expressed in human breast tumors. Mol Cell Endocrinol. 2005 Dec 21;245(1-2):53-9. doi: 10.1016/j.mce.2005.10.003. Epub 2005 Nov 17.
• [748] (9)-Tetrahydrocannabinol Suppresses Monocyte-Mediated Astrocyte Production of Monocyte Chemoattractant Protein 1 and Interleukin-6 in a Toll-Like Receptor 7-Stimulated Human Coculture. J Pharmacol Exp Ther. 2019 Oct;371(1):191-201. doi: 10.1124/jpet.119.260661. Epub 2019 Aug 5.
• [749] Blood cell oxidative stress precedes hemolysis in whole blood-liver slice co-cultures of rat, dog, and human tissues. Toxicol Appl Pharmacol. 2010 May 1;244(3):354-65. doi: 10.1016/j.taap.2010.01.017. Epub 2010 Feb 6.
• [750] High-dose mitoxantrone induces programmed cell death or apoptosis in human myeloid leukemia cells. Blood. 1993 Nov 15;82(10):3133-40.
• [751] Gene expression data from acetaminophen-induced toxicity in human hepatic in vitro systems and clinical liver samples. Data Brief. 2016 Mar 26;7:1052-1057. doi: 10.1016/j.dib.2016.03.069. eCollection 2016 Jun.
• [752] Inhibition of autophagic flux differently modulates cannabidiol-induced death in 2D and 3D glioblastoma cell cultures. Sci Rep. 2020 Feb 14;10(1):2687. doi: 10.1038/s41598-020-59468-4.
• [753] Nitrogen mustard prevents transport of Fra-1 into the nucleus to promote c-Fos- and FosB-dependent IL-8 induction in injured mouse epidermis. Toxicol Lett. 2020 Feb 1;319:256-263. doi: 10.1016/j.toxlet.2019.10.006. Epub 2019 Oct 19.
• [754] Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res. 2002 Aug 1;62(15):4419-26.
• [755] Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cells. J Biol Chem. 2002 Nov 15;277(46):43648-58. doi: 10.1074/jbc.M203214200. Epub 2002 Sep 6.
• [756] [Regulation mechanism of autophagy-related protein LC3 by c-Jun in methotrexate resistant human choriocarcinoma JEG-3 cells]. Zhonghua Fu Chan Ke Za Zhi. 2014 Jul;49(7):531-5.
• [757] Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction. J Toxicol Sci. 2020;45(11):673-680. doi: 10.2131/jts.45.673.
• [758] Activation of inflammasomes by tyrosine kinase inhibitors of vascular endothelial growth factor receptor: Implications for VEGFR TKIs-induced immune related adverse events. Toxicol In Vitro. 2021 Mar;71:105063. doi: 10.1016/j.tiv.2020.105063. Epub 2020 Dec 1.
• [759] Dihydroartemisinin induces pyroptosis by promoting the AIM2/caspase-3/DFNA5 axis in breast cancer cells. Chem Biol Interact. 2021 May 1;340:109434. doi: 10.1016/j.cbi.2021.109434. Epub 2021 Mar 6.
• [760] Evidence of securin-mediated resistance to gefitinib-induced apoptosis in human cancer cells. Chem Biol Interact. 2013 Apr 25;203(2):412-22. doi: 10.1016/j.cbi.2013.03.011. Epub 2013 Mar 22.
• [761] Cigarette smoke and asbestos activate poly-ADP-ribose polymerase in alveolar epithelial cells. J Investig Med. 2001 Jan;49(1):68-76. doi: 10.2310/6650.2001.34092.
• [762] Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
• [763] The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation. J Biochem Mol Toxicol. 1999;13(6):338-47. doi: 10.1002/(sici)1099-0461(1999)13:6<338::aid-jbt8>3.0.co;2-7.
• [764] Ciprofloxacin mediated cell growth inhibition, S/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line. Clin Cancer Res. 2000 Mar;6(3):891-900.
• [765] Investigation of molecular mechanisms underlying the antiproliferative effects of colchicine against PC3 prostate cancer cells. Toxicol In Vitro. 2021 Jun;73:105138. doi: 10.1016/j.tiv.2021.105138. Epub 2021 Mar 6.
• [766] Sulindac enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human lung cancer. Mol Cancer Ther. 2005 Feb;4(2):291-304.
• [767] Methotrexate induces poly(ADP-ribose) polymerase-dependent, caspase 3-independent apoptosis in subsets of proliferating CD4+ T cells. Clin Exp Immunol. 2007 May;148(2):288-95. doi: 10.1111/j.1365-2249.2007.03335.x. Epub 2007 Feb 7.
• [768] 4.8% sevoflurane induces activation of autophagy in human neuroblastoma SH-SY5Y cells by the AMPK/mTOR signaling pathway. Neurotoxicology. 2022 May;90:256-264. doi: 10.1016/j.neuro.2022.04.008. Epub 2022 Apr 23.
• [769] Enhanced chemotherapeutic efficacy of docetaxel in human lung cancer cell line via GLUT1 inhibitor. J Biochem Mol Toxicol. 2023 Jun;37(6):e23348. doi: 10.1002/jbt.23348. Epub 2023 Mar 31.
• [770] Breast cancer cells response to the antineoplastic agents cisplatin, carboplatin, and doxorubicin at the mRNA expression levels of distinct apoptosis-related genes, including the new member, BCL2L12. Ann N Y Acad Sci. 2007 Jan;1095:35-44. doi: 10.1196/annals.1397.005.
• [771] Extracellular signal-regulated kinase activation and Bcl-2 downregulation mediate apoptosis after gemcitabine treatment partly via a p53-independent pathway. Eur J Pharmacol. 2004 Oct 19;502(3):169-83. doi: 10.1016/j.ejphar.2004.09.006.
• [772] Verapamil potentiates anti-glioblastoma efficacy of temozolomide by modulating apoptotic signaling. Toxicol In Vitro. 2018 Oct;52:306-313. doi: 10.1016/j.tiv.2018.07.001. Epub 2018 Jul 9.
• [773] Inhibition of caspase-dependent mitochondrial permeability transition protects airway epithelial cells against mustard-induced apoptosis. Apoptosis. 2006 Sep;11(9):1545-59. doi: 10.1007/s10495-006-8764-1.
• [774] -Carotene Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cell Lines via the Cav-1/AKT/NF-B Signaling Pathway. J Biochem Mol Toxicol. 2016 Mar;30(3):148-57. doi: 10.1002/jbt.21773. Epub 2016 Jan 6.
• [775] Hsa-let-7g miRNA regulates the anti-tumor effects of gastric cancer cells under oxidative stress through the expression of DDR genes. J Toxicol Sci. 2015 Jun;40(3):329-38. doi: 10.2131/jts.40.329.
• [776] Synthesis and structure-activity relationships of new antiproliferative and proapoptotic retinoid-related biphenyl-4-yl-acrylic acids. Bioorg Med Chem. 2007 Jul 15;15(14):4863-75. doi: 10.1016/j.bmc.2007.04.057. Epub 2007 May 3.
• [777] Methotrexate induces apoptosis through p53/p21-dependent pathway and increases E-cadherin expression through downregulation of HDAC/EZH2. Biochem Pharmacol. 2011 Feb 15;81(4):510-7. doi: 10.1016/j.bcp.2010.11.014. Epub 2010 Nov 27.
• [778] Actinomycin D inhibits the expression of the cystine/glutamate transporter xCT via attenuation of CD133 synthesis in CD133(+) HCC. Chem Biol Interact. 2019 Aug 25;309:108713. doi: 10.1016/j.cbi.2019.06.026. Epub 2019 Jun 19.
• [779] Simvastatin and purine analogs have a synergic effect on apoptosis of chronic lymphocytic leukemia cells. Ann Hematol. 2010 Nov;89(11):1115-24. doi: 10.1007/s00277-010-0988-z. Epub 2010 May 25.
• [780] The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib. Toxicol Sci. 2023 Dec 21;197(1):69-78. doi: 10.1093/toxsci/kfad099.
• [781] The isoflavonoids genistein and quercetin activate different stress signaling pathways as shown by analysis of site-specific phosphorylation of ATM, p53 and histone H2AX. DNA Repair (Amst). 2004 Mar 4;3(3):235-44. doi: 10.1016/j.dnarep.2003.10.014.
• [782] Chromium III histidinate exposure modulates gene expression in HaCaT human keratinocytes exposed to oxidative stress. Biol Trace Elem Res. 2010 Oct;137(1):23-39.
• [783] A dual role of p21waf1/cip1 gene in apoptosis of HEp-2 treated with cisplatin or methotrexate. Cancer Gene Ther. 2008 Sep;15(9):576-90. doi: 10.1038/cgt.2008.28. Epub 2008 May 16.
• [784] The Effect of GADD45a on Furazolidone-Induced S-Phase Cell-Cycle Arrest in Human Hepatoma G2 Cells. J Biochem Mol Toxicol. 2015 Oct;29(10):489-495. doi: 10.1002/jbt.21719. Epub 2015 Jun 11.
• [785] Signaling pathways involved in induction of GADD45 gene expression and apoptosis by troglitazone in human MCF-7 breast carcinoma cells. Oncogene. 2004 Jun 3;23(26):4614-23. doi: 10.1038/sj.onc.1207598.
• [786] Topotecan and methotrexate alter expression of the apoptosis-related genes BCL2, FAS and BCL2L12 in leukemic HL-60 cells. Biol Chem. 2006 Dec;387(12):1629-33. doi: 10.1515/BC.2006.203.
• [787] Carvedilol prevents epinephrine-induced apoptosis in human coronary artery endothelial cells: modulation of Fas/Fas ligand and caspase-3 pathway. Cardiovasc Res. 2000 Feb;45(3):788-94. doi: 10.1016/s0008-6363(99)00369-7.
• [788] Regulatory role of KEAP1 and NRF2 in PPAR expression and chemoresistance in human non-small-cell lung carcinoma cells. Free Radic Biol Med. 2012 Aug 15;53(4):758-68. doi: 10.1016/j.freeradbiomed.2012.05.041. Epub 2012 Jun 7.
• [789] Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
• [790] BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile. J Biochem Mol Toxicol. 2019 May;33(5):e22286. doi: 10.1002/jbt.22286. Epub 2019 Jan 23.
• [791] Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. Br J Dermatol. 2009 Mar;160(3):519-26. doi: 10.1111/j.1365-2133.2008.08931.x. Epub 2008 Nov 25.
• [792] Glucocorticoids induce G1 arrest of lymphoblastic cells through retinoblastoma protein Rb1 dephosphorylation in childhood acute lymphoblastic leukemia in vivo. Cancer Biol Ther. 2004 May;3(5):470-6. doi: 10.4161/cbt.3.5.838. Epub 2004 May 9.
• [793] Different apoptosis ratios and gene expressions in two human cell lines after sevoflurane anaesthesia. Acta Anaesthesiol Scand. 2009 Oct;53(9):1192-9. doi: 10.1111/j.1399-6576.2009.02036.x. Epub 2009 Jun 30.
• [794] [Mechanisms underlying the effect of arsenic trioxide on proliferation inhibition and apoptosis induction in myeloma cell line u266]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2007 Oct;15(5):982-5.
• [795] Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPAR-dependent pathway. Oncotarget. 2016 Mar 1;7(9):10345-62. doi: 10.18632/oncotarget.7213.
• [796] Induction of apoptosis by cidofovir in human papillomavirus (HPV)-positive cells. Oncol Res. 2000;12(9-10):397-408. doi: 10.3727/096504001108747855.
• [797] Comparison of burst of reactive oxygen species and activation of caspase-3 in apoptosis of K562 and HL-60 cells induced by docetaxel. Cancer Lett. 2004 Oct 8;214(1):103-13. doi: 10.1016/j.canlet.2004.03.047.
• [798] Induction of mitochondrial manganese superoxide dismutase confers resistance to apoptosis in acute myeloblastic leukaemia cells exposed to etoposide. Br J Haematol. 2000 Mar;108(3):574-81. doi: 10.1046/j.1365-2141.2000.01852.x.
• [799] Cisplatin-enhanced sensitivity of glioblastoma multiforme U251 cells to adenovirus-delivered TRAIL in vitro. Tumour Biol. 2010 Dec;31(6):613-22. doi: 10.1007/s13277-010-0077-x. Epub 2010 Jul 11.
• [800] Insulin-like growth factor I is the key growth factor in serum that protects neuroblastoma cells from hyperosmotic-induced apoptosis. J Cell Physiol. 2000 Jan;182(1):24-32. doi: 10.1002/(SICI)1097-4652(200001)182:1<24::AID-JCP3>3.0.CO;2-6.
• [801] mRNA expression analysis of a variety of apoptosis-related genes, including the novel gene of the BCL2-family, BCL2L12, in HL-60 leukemia cells after treatment with carboplatin and doxorubicin. Biol Chem. 2004 Nov;385(11):1099-103. doi: 10.1515/BC.2004.143.
• [802] Neurokinin-1 receptor (NK1R) inhibition sensitizes APL cells to anti-tumor effect of arsenic trioxide via restriction of NF-B axis: Shedding new light on resistance to Aprepitant. Int J Biochem Cell Biol. 2018 Oct;103:105-114. doi: 10.1016/j.biocel.2018.08.010. Epub 2018 Aug 23.
• [803] Differentiation-associated alteration in gene expression of importins and exportins in human leukemia HL-60 cells. Biomed Res. 2008 Jun;29(3):141-5. doi: 10.2220/biomedres.29.141.
• [804] Effect of Ivermectin and Atorvastatin on Nuclear Localization of Importin Alpha and Drug Target Expression Profiling in Host Cells from Nasopharyngeal Swabs of SARS-CoV-2- Positive Patients. Viruses. 2021 Oct 15;13(10):2084. doi: 10.3390/v13102084.
• [805] Gypenosides protect retinal pigment epithelium cells from oxidative stress. Food Chem Toxicol. 2018 Feb;112:76-85.
• [806] Capsaicin inhibits the migration, invasion and EMT of renal cancer cells by inducing AMPK/mTOR-mediated autophagy. Chem Biol Interact. 2022 Oct 1;366:110043. doi: 10.1016/j.cbi.2022.110043. Epub 2022 Aug 28.
• [807] A prospective evaluation of ifosfamide-related nephrotoxicity in children and young adults. Cancer. 1995 Dec 15;76(12):2557-64. doi: 10.1002/1097-0142(19951215)76:12<2557::aid-cncr2820761223>3.0.co;2-9.
• [808] Serum clara-cell protein and beta2-microglobulin as early markers of occupational exposure to nitric oxides. Inhal Toxicol. 2005 Feb;17(2):87-97. doi: 10.1080/08958370590899460.
• [809] Changes of bone markers during long-term intravenous calcitriol therapy in maintenance dialysis patients. Miner Electrolyte Metab. 1996;22(4):219-23.
• [810] Pamidronate increases markers of bone formation in patients with multiple myeloma in plateau phase under interferon-alpha treatment. Calcif Tissue Int. 2001 May;68(5):285-90.
• [811] Suppression of RAGE as a basis of simvastatin-dependent plaque stabilization in type 2 diabetes. Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2716-23.
• [812] Prevention of deoxycholate-induced gastric apoptosis by aspirin: roles of NF-kappaB and PKC signaling. J Surg Res. 2008 Mar;145(1):66-73. doi: 10.1016/j.jss.2007.04.039. Epub 2007 Jul 20.
• [813] Peroxisome proliferator-activated receptor-gamma agonists inhibit respiratory syncytial virus-induced expression of intercellular adhesion molecule-1 in human lung epithelial cells. Immunology. 2007 May;121(1):71-81. doi: 10.1111/j.1365-2567.2006.02539.x.
• [814] Glucosamine regulation of LPS-mediated inflammation in human bronchial epithelial cells. Eur J Pharmacol. 2010 Jun 10;635(1-3):219-26. doi: 10.1016/j.ejphar.2010.02.044. Epub 2010 Mar 20.
• [815] Effects of gonadotrophin-releasing hormone agonists on apoptosis of granulosa cells. Ann N Y Acad Sci. 2005 May;1042:531-7. doi: 10.1196/annals.1338.065.
• [816] Combining kallistatin gene therapy and meloxicam to treat hepatocellular carcinoma in mice. Cancer Sci. 2009 Nov;100(11):2226-33. doi: 10.1111/j.1349-7006.2009.01306.x. Epub 2009 Aug 4.
• [817] The role of MITF and Mcl-1 proteins in the antiproliferative and proapoptotic effect of ciprofloxacin in amelanotic melanoma cells: In silico and in vitro study. Toxicol In Vitro. 2020 Aug;66:104884. doi: 10.1016/j.tiv.2020.104884. Epub 2020 May 8.
• [818] Quercetin downregulates Mcl-1 by acting on mRNA stability and protein degradation. Br J Cancer. 2011 Jul 12;105(2):221-30. doi: 10.1038/bjc.2011.229.
• [819] Anti-cancer properties of glucosamine-hydrochloride in YD-8 human oral cancer cells: Induction of the caspase-dependent apoptosis and down-regulation of HIF-1. Toxicol In Vitro. 2012 Feb;26(1):42-50. doi: 10.1016/j.tiv.2011.10.005. Epub 2011 Oct 13.
• [820] Ethacrynic acid and a derivative enhance apoptosis in arsenic trioxide-treated myeloid leukemia and lymphoma cells: the role of glutathione S-transferase p1-1. Clin Cancer Res. 2012 Dec 15;18(24):6690-701. doi: 10.1158/1078-0432.CCR-12-0770. Epub 2012 Oct 18.
• [821] Effect of all-trans retinoic acid on sodium/iodide symporter expression, radioiodine uptake and gene expression profiles in a human anaplastic thyroid carcinoma cell line. Nucl Med Biol. 2006 Oct;33(7):875-82. doi: 10.1016/j.nucmedbio.2006.07.004.
• [822] Systematic transcriptome-based comparison of cellular adaptive stress response activation networks in hepatic stem cell-derived progeny and primary human hepatocytes. Toxicol In Vitro. 2021 Jun;73:105107. doi: 10.1016/j.tiv.2021.105107. Epub 2021 Feb 3.
• [823] [Expression and function of Ahi-1 gene in Jurkat cells]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009 Apr;17(2):445-9.
• [824] Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide. Br J Pharmacol. 2001 Oct;134(4):845-52. doi: 10.1038/sj.bjp.0704327.
• [825] Comparison of protective effect of ascorbic acid on redox and endocannabinoid systems interactions in in vitro cultured human skin fibroblasts exposed to UV radiation and hydrogen peroxide. Arch Dermatol Res. 2017 May;309(4):285-303. doi: 10.1007/s00403-017-1729-0. Epub 2017 Mar 11.
• [826] The anthelminthic drug praziquantel is a selective agonist of the sensory transient receptor potential melastatin type 8 channel. Toxicol Appl Pharmacol. 2017 Dec 1;336:55-65. doi: 10.1016/j.taap.2017.10.012. Epub 2017 Oct 18.
• [827] The vanilloid receptor TRPV1 is activated and sensitized by local anesthetics in rodent sensory neurons. J Clin Invest. 2008 Feb;118(2):763-76. doi: 10.1172/JCI32751.
• [828] Genetic factors underlying the risk of thalidomide-related neuropathy in patients with multiple myeloma. J Clin Oncol. 2011 Mar 1;29(7):797-804. doi: 10.1200/JCO.2010.28.0792. Epub 2011 Jan 18.
• [829] Alcohol and Cannabinoids Differentially Affect HIV Infection and Function of Human Monocyte-Derived Dendritic Cells (MDDC). Front Microbiol. 2015 Dec 22;6:1452. doi: 10.3389/fmicb.2015.01452. eCollection 2015.
• [830] Tacrolimus suppressed the production of cytokines involved in atopic dermatitis by direct stimulation of human PBMC system. (Comparison with steroids). Int Immunopharmacol. 2001 Jun;1(6):1219-26. doi: 10.1016/s1567-5769(01)00059-5.
• [831] Effects of theophylline, dexamethasone and salbutamol on cytokine gene expression in human peripheral blood CD4+ T-cells. Eur Respir J. 1999 Nov;14(5):1106-12. doi: 10.1183/09031936.99.14511069.
• [832] Dietary flavonoids induce MLL translocations in primary human CD34+ cells. Carcinogenesis. 2007 Aug;28(8):1703-9. doi: 10.1093/carcin/bgm102. Epub 2007 Apr 29.
• [833] Differential responses to retinoic acid and endocrine disruptor compounds of subpopulations within human embryonic stem cell lines. Differentiation. 2012 Nov;84(4):330-43. doi: 10.1016/j.diff.2012.07.006. Epub 2012 Aug 18.
• [834] Alcohol triggered bile acid disequilibrium by suppressing BSEP to sustain hepatocellular carcinoma progression. Chem Biol Interact. 2022 Apr 1;356:109847. doi: 10.1016/j.cbi.2022.109847. Epub 2022 Feb 9.
• [835] Prefrontal dysfunction in schizophrenia involves mixed-lineage leukemia 1-regulated histone methylation at GABAergic gene promoters. J Neurosci. 2007 Oct 17;27(42):11254-62. doi: 10.1523/JNEUROSCI.3272-07.2007.
• [836] The broken MLL gene is frequently located outside the inherent chromosome territory in human lymphoid cells treated with DNA topoisomerase II poison etoposide. PLoS One. 2013 Sep 25;8(9):e75871. doi: 10.1371/journal.pone.0075871. eCollection 2013.
• [837] Pentosan polysulfate decreases proliferation and extracellular matrix deposition by vascular smooth muscle cells isolated from failed hemodialysis access grafts. Clin Nephrol. 2000 Aug;54(2):121-7.
• [838] Possible roles of a tumor suppressor gene PIG11 in hepatocarcinogenesis and As2O3-induced apoptosis in liver cancer cells. J Gastroenterol. 2009;44(5):460-9. doi: 10.1007/s00535-009-0030-1. Epub 2009 Apr 1.
• [839] Expression profiling of the estrogen responsive genes in response to phytoestrogens using a customized DNA microarray. FEBS Lett. 2005 Mar 14;579(7):1732-40.
• [840] Quercetin inhibits HGF/c-Met signaling and HGF-stimulated melanoma cell migration and invasion. Mol Cancer. 2015 May 14;14:103. doi: 10.1186/s12943-015-0367-4.
• [841] Agonists of the retinoic acid- and retinoid X-receptors inhibit hepatocyte growth factor secretion and expression in U87 human astrocytoma cells. Brain Res Mol Brain Res. 2001 Feb 19;87(1):100-8. doi: 10.1016/s0165-3806(00)00154-1.
• [842] Effects of nevirapine and efavirenz on human adipocyte differentiation, gene expression, and release of adipokines and cytokines. Antiviral Res. 2011 Aug;91(2):112-9. doi: 10.1016/j.antiviral.2011.04.018. Epub 2011 May 17.
• [843] The effect of NSAIDs and a COX-2 specific inhibitor on Helicobacter pylori-induced PGE2 and HGF in human gastric fibroblasts. Aliment Pharmacol Ther. 2000 Apr;14 Suppl 1:44-9. doi: 10.1046/j.1365-2036.2000.014s1044.x.
• [844] Combination of thalidomide and cisplatin in an head and neck squamous cell carcinomas model results in an enhanced antiangiogenic activity in vitro and in vivo. Int J Cancer. 2007 Oct 15;121(8):1697-704. doi: 10.1002/ijc.22867.
• [845] Regulation of keratinocyte growth factor and scatter factor in cyclosporin-induced gingival overgrowth. J Oral Pathol Med. 2004 Aug;33(7):391-7. doi: 10.1111/j.1600-0714.2004.00223.x.
• [846] Characterization of multidrug transporter-mediated efflux of avermectins in human and mouse neuroblastoma cell lines. Toxicol Lett. 2015 Jun 15;235(3):189-98. doi: 10.1016/j.toxlet.2015.04.005. Epub 2015 Apr 9.
• [847] Folate concentration dependent transport activity of the Multidrug Resistance Protein 1 (ABCC1). Biochem Pharmacol. 2004 Apr 15;67(8):1541-8.
• [848] Methotrexate normalizes up-regulated folate pathway genes in rheumatoid arthritis. Arthritis Rheum. 2013 Nov;65(11):2791-802.
• [849] Influence of redox-active compounds and PXR-activators on human MRP1 and MRP2 gene expression. Toxicology. 2002 Feb 28;171(2-3):137-46.
• [850] Enhanced in vitro invasiveness and drug resistance with altered gene expression patterns in a human lung carcinoma cell line after pulse selection with anticancer drugs. Int J Cancer. 2004 Sep 10;111(4):484-93. doi: 10.1002/ijc.20230.
• [851] Co-encapsulation of chrysophsin-1 and epirubicin in PEGylated liposomes circumvents multidrug resistance in HeLa cells. Chem Biol Interact. 2015 Dec 5;242:13-23. doi: 10.1016/j.cbi.2015.08.023. Epub 2015 Sep 1.
• [852] Upregulation of multi drug resistance genes in doxorubicin resistant human acute myelogeneous leukemia cells and reversal of the resistance. Hematology. 2007 Dec;12(6):511-7. doi: 10.1080/10245330701562535.
• [853] Functional analysis of MRP1 cloned from bovine. FEBS Lett. 2002 Jun 19;521(1-3):211-3. doi: 10.1016/s0014-5793(02)02816-8.
• [854] p53-R175H mutant gains new function in regulation of doxorubicin-induced apoptosis. Int J Cancer. 2005 Apr 10;114(3):331-6. doi: 10.1002/ijc.20818.
• [855] Azidothymidine and cisplatin increase p14ARF expression in OVCAR-3 ovarian cancer cell line. Toxicol Appl Pharmacol. 2006 Oct 1;216(1):89-97. doi: 10.1016/j.taap.2006.04.015. Epub 2006 May 19.
• [856] Quantitative analysis of gene expression changes in response to genotoxic compounds. Toxicol In Vitro. 2017 Mar;39:15-28. doi: 10.1016/j.tiv.2016.11.004. Epub 2016 Nov 5.
• [857] Gallic acid potentiates the apoptotic effect of paclitaxel and carboplatin via overexpression of Bax and P53 on the MCF-7 human breast cancer cell line. J Biochem Mol Toxicol. 2021 Feb;35(2):e22638. doi: 10.1002/jbt.22638. Epub 2020 Oct 1.
• [858] Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage. Nucleic Acids Res. 2009 Jan;37(1):78-95. doi: 10.1093/nar/gkn910. Epub 2008 Nov 16.
• [859] Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget. 2019 Jan 1;10(1):45-59. doi: 10.18632/oncotarget.26534. eCollection 2019 Jan 1.
• [860] Nitrogen Mustard Alkylates and Cross-Links p53 in Human Keratinocytes. Chem Res Toxicol. 2022 Apr 18;35(4):636-650. doi: 10.1021/acs.chemrestox.1c00420. Epub 2022 Mar 21.
• [861] Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2/M arrest and inducing apoptosis. Food Chem Toxicol. 2008 Jun;46(6):2042-53. doi: 10.1016/j.fct.2008.01.049. Epub 2008 Feb 7.
• [862] Hydroquinone increases 5-hydroxymethylcytosine formation through ten eleven translocation 1 (TET1) 5-methylcytosine dioxygenase. J Biol Chem. 2013 Oct 4;288(40):28792-800. doi: 10.1074/jbc.M113.491365. Epub 2013 Aug 12.
• [863] Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95-independent manner in human gastric adenocarcinoma cells. Cancer Lett. 2000 Oct 1;158(2):125-32. doi: 10.1016/s0304-3835(00)00489-4.
• [864] Multi-level gene expression profiles affected by thymidylate synthase and 5-fluorouracil in colon cancer. BMC Genomics. 2006 Apr 3;7:68. doi: 10.1186/1471-2164-7-68.
• [865] Protein kinase Czeta abrogates the proapoptotic function of Bax through phosphorylation. J Biol Chem. 2007 Jul 20;282(29):21268-77. doi: 10.1074/jbc.M701613200. Epub 2007 May 24.
• [866] Regulation of aryl hydrocarbon receptor function by selective estrogen receptor modulators. Mol Endocrinol. 2010 Jan;24(1):33-46.
• [867] Astaxanthin protects mesenchymal stem cells from oxidative stress by direct scavenging of free radicals and modulation of cell signaling. Chem Biol Interact. 2021 Jan 5;333:109324. doi: 10.1016/j.cbi.2020.109324. Epub 2020 Nov 17.
• [868] Comparative effects of retinoic acid, vitamin D and resveratrol alone and in combination with adenosine analogues on methylation and expression of phosphatase and tensin homologue tumour suppressor gene in breast cancer cells. Br J Nutr. 2012 Mar;107(6):781-90. doi: 10.1017/S0007114511003631. Epub 2011 Aug 1.
• [869] Arsenic trioxide inhibits the proliferation of myeloma cell line through notch signaling pathway. Cancer Cell Int. 2013 Mar 13;13(1):25. doi: 10.1186/1475-2867-13-25.
• [870] Mechanism of thalidomide to enhance cytotoxicity of temozolomide in U251-MG glioma cells in vitro. Chin Med J (Engl). 2009 Jun 5;122(11):1260-6.
• [871] Influence of glutathione S-transferase A1, P1, M1, T1 polymorphisms on oral busulfan pharmacokinetics in children with congenital hemoglobinopathies undergoing hematopoietic stem cell transplantation. Pediatr Blood Cancer. 2010 Dec 1;55(6):1172-9. doi: 10.1002/pbc.22739.
• [872] Glutathione-S-transferase genotypes and the adverse effects of azathioprine in young patients with inflammatory bowel disease. Inflamm Bowel Dis. 2007 Jan;13(1):57-64. doi: 10.1002/ibd.20004.
• [873] Association of polymorphism in alcohol dehydrogenase and interaction with other genetic risk factors with alcoholic liver cirrhosis. Drug Alcohol Depend. 2010 Jun 1;109(1-3):190-7. doi: 10.1016/j.drugalcdep.2010.01.010. Epub 2010 Feb 18.
• [874] Inhibition of human glutathione S-transferases by dopamine, alpha-methyldopa and their 5-S-glutathionyl conjugates. Chem Biol Interact. 1994 Jan;90(1):87-99.
• [875] Functional inference of the methylenetetrahydrofolate reductase 677C > T and 1298A > C polymorphisms from a large-scale epidemiological study. Hum Genet. 2007 Mar;121(1):57-64. doi: 10.1007/s00439-006-0290-2. Epub 2006 Nov 18.
• [876] A common haplotype on methylenetetrahydrofolate reductase gene modifies the effect of angiotensin-converting enzyme inhibitor on blood pressure in essential hypertension patients--a family-based association study. Clin Exp Hypertens. 2005 Aug;27(6):509-21.
• [877] Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphism in normal tissue as predictors of fluorouracil sensitivity. J Clin Oncol. 2005 Mar 1;23(7):1365-9. doi: 10.1200/JCO.2005.06.219.
• [878] Homocysteine modulates the effect of simvastatin on expression of ApoA-I and NF-kappaB/iNOS. Cardiovasc Res. 2008 Oct 1;80(1):151-8.
• [879] Nonenantioselectivity property of human deoxycytidine kinase explained by structures of the enzyme in complex with L- and D-nucleosides. J Med Chem. 2007 Jun 28;50(13):3004-14. doi: 10.1021/jm0700215. Epub 2007 May 27.