Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMZSXQ)

• Drug Name: Azathioprine Drug Info
• Synonyms: Azamun; Azanin; Azasan; Azathioprin; Azathioprinum; Azathiopurine; Azatioprin; Azatioprina; Azothioprine; Ccucol; Cytostatics; Immuran; Imuran; Imurek; Imurel; Methylnitroimidazolylmercaptopurine; Muran; Azamun [Czech]; Azathioprine sodium; Azatiopr in; A 4638; BW 57322; Azamun (TN); Azasan (TN); Azathioprinum [INN-Latin]; Azatioprina [INN-Spanish]; BW 57-322; Imuran (TN); Imurel (TN); [Methyl(nitroimidazolyl)mercaptopurine]; AI-981/34845012; BW-57-322; Azathioprine (JP15/USP/INN); Azathioprine [USAN:INN:BAN:JAN]; B. W. 57-322; Thiopurine 6-(1-methyl-4-nitroimidazol-5-yl); Azasan, Imuran, Azamun, BW-57-322, NSC-39084, Azathioprine; 6-((1-Methyl-4-nitro-1H-imidazol-5-yl)thio)-1H-purine; 6-((1-Methyl-4-nitroimidazol-5-yl)thio)purine; 6-(1'-Methyl-4'-nitro-5'-imidazolyl)-mercaptopurine; 6-(1'-Methyl-4'-nitro-5'-imidazolyl)mercaptopurine; 6-(1-Methyl-4-nitroimidazol-5-yl)thiopurine; 6-(1-Methyl-4-nitroimidazol-5-ylthio)purin; 6-(1-Methyl-4-nitroimidazol-5-ylthio)purin [Czech]; 6-(1-Methyl-p-nitro-5-imidazolyl)-thiopurine; 6-(1-Methyl-p-nitro-5-imidazolyl)thiopurine; 6-(3-Methyl-5-nitro-3H-imidazol-4-ylsulfanyl)-7H-purine; 6-(3-methyl-5-nitroimidazol-4-yl)sulfanyl-7H-purine; 6-(Methyl-p-nitro-5-imidazolyl)-thiopurine; 6-(Methyl-p-nitro-5-imidazolyl)thiopurine; 6-({4-nitro-1-methyl-1H-imidazol-5-yl}sulfanyl)-7H-purine; 6-1'-Methyl,4'-nitro,5'-imidazolyl mercaptopurine; 6-[(1-Methyl-4-nitroimidazol-5-yl)-thio] purine; 6-[(1-Methyl-4-nitroimidazol-5-yl)thio]purine; 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)sulfanyl]-7H-purine; 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-Purine; 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-7H-purine; 6-[(1-methyl-4-nitro-1H-imidazol-5-yl)thio]-9H-purine

Indication

Disease Entry	ICD 11	Status	REF
Lupus nephritis	4A40.0Y	Approved	[1]
Organ transplant rejection	NE84	Approved	[2]

• Therapeutic Class: Immunosuppressive Agents
• Cross-matching ID:
  PubChem CID: 2265
  ChEBI ID: CHEBI:2948
  CAS Number: CAS 446-86-6
  TTD Drug ID: DMMZSXQ
  VARIDT Drug ID: DR00113
  INTEDE Drug ID: DR0164
  ACDINA Drug ID: D00054

Molecule-Related Drug Atlas

Drug(s) Targeting Amidophosphoribosyltransferase (PPAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[10]
Mycophenolic hydroxamic acid	DM4YRAH	Discovery agent	N.A.	Investigative	[11]
Tiazofurin adenine dinucleotide	DMEFVPH	Discovery agent	N.A.	Investigative	[12]
Mycophenolic bis(sulfonamide)	DMUQP3J	Discovery agent	N.A.	Investigative	[13]
6-Chloropurine Riboside, 5'-Monophosphate	DMWB43U	Discovery agent	N.A.	Investigative	[14]

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[15]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[16]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[17]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[18]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[17]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[17]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[19]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[17]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[20]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[21]

Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[22]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[23]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[24]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[25]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[26]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[27]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[28]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[29]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[30]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[31]

Drug(s) Metabolized By Thiopurine methyltransferase (TPMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[32]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[33]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[34]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[35]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[36]
Vitamin C	DMXJ7O8	Adenocarcinoma	2D40	Approved	[37]
Cefazolin	DMPDYFR	Bacteremia	1A73	Approved	[38]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[39]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[40]
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[41]

Drug(s) Metabolized By Glutathione S-transferase alpha-2 (GSTA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[42]

Drug(s) Metabolized By Glutathione S-transferase mu-1 (GSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[43]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[44]
Carboplatin	DMG281S	Adenocarcinoma	2D40	Approved	[44]
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[45]

Drug(s) Affected By Thiopurine S-methyltransferase (TPMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[46]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[47]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[48]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[49]
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[50]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[51]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[52]
Bendroflumethiazide	DM7EVLC	High blood pressure	BA00	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]

Drug(s) Affected By Glutathione S-transferase A2 (GSTA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[56]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[60]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[62]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[63]
Mefenamic acid	DMK7HFI	Dysmenorrhea	GA34.3	Approved	[64]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[65]

Drug(s) Affected By Glutathione S-transferase Mu 1 (GSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[69]
Methyldopa	DM5I621	Hypertension	BA00-BA04	Approved	[70]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[73]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[74]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[75]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[76]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[77]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[78]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[79]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[80]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[81]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[82]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[80]

Drug(s) Affected By Inosine triphosphate pyrophosphatase (ITPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[88]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[89]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[88]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]

Drug(s) Affected By Dipeptidyl peptidase 4 (DPP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Saxagliptin	DMGXENV	Type-2 diabetes	5A11	Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Alogliptin	DM8WI3R	Type-2 diabetes	5A11	Approved	[95]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[97]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]

Drug(s) Affected By Solute carrier family 15 member 1 (SLC15A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[99]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[100]
Repaglinide	DM5SXUV	Diabetic complication	5A2Y	Approved	[101]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[102]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[103]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[104]

Drug(s) Affected By Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[106]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[108]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[110]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[113]

Drug(s) Affected By Glutathione peroxidase 2 (GPX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[116]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[118]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[120]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[121]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]

Drug(s) Affected By Glutathione peroxidase 3 (GPX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[99]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[125]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[126]

Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[116]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[99]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[129]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[130]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[132]

Drug(s) Affected By Glutathione synthetase (GSS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[133]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[136]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[138]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[110]

Drug(s) Affected By CCN family member 1 (CCN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[139]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[142]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]

Drug(s) Affected By Phospholipid phosphatase 3 (PLPP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[99]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[146]

Drug(s) Affected By Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[147]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[73]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[149]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]

Drug(s) Affected By Calmegin (CLGN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[152]

Drug(s) Affected By D-3-phosphoglycerate dehydrogenase (PHGDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[99]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[153]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]

Drug(s) Affected By Receptor-interacting serine/threonine-protein kinase 2 (RIPK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[154]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[155]

Drug(s) Affected By Gasdermin-E (GSDME)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[156]
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[157]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]

Drug(s) Affected By Toll-like receptor 2 (TLR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[158]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[159]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[160]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[161]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[162]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[158]

Drug(s) Affected By Ectonucleoside triphosphate diphosphohydrolase 3 (ENTPD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[163]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[164]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[165]

Drug(s) Affected By Antiviral innate immune response receptor RIG-I (RIGI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[166]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[167]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[9]

Drug(s) Affected By 2'-5'-oligoadenylate synthase 1 (OAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[99]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[169]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]

Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[46]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[170]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[171]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[172]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[173]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[174]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[175]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[176]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[177]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[178]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Selenium	DM25CGV	N. A.	N. A.	Approved	[180]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[181]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[182]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[183]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[184]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[185]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[186]

Drug(s) Affected By Ubiquitin-like protein ISG15 (ISG15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[187]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[188]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[189]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[73]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[149]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[190]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[191]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[192]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[193]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[194]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[195]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[196]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[197]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]

Drug(s) Affected By Asparagine synthetase (ASNS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[198]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[199]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[200]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[199]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[201]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[202]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[199]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]

Drug(s) Affected By Hepatocyte growth factor receptor (MET)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cabozantinib	DMIYDT4	Medullary thyroid gland carcinoma		Approved	[203]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[204]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[205]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[205]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[205]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[205]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]

Drug(s) Affected By Steryl-sulfatase (STS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Tazarotene	DM8SMD1	Acne vulgaris	ED80	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]
Danazol	DML8KTN	Menorrhagia	GA20.50	Approved	[209]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[207]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[210]

Drug(s) Affected By Neuromedin-B (NMB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[211]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[212]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[9]

Drug(s) Affected By Stromelysin-2 (MMP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[54]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[191]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[139]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[69]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]
Haloperidol	DM96SE0	Delirium		Approved	[213]

Drug(s) Affected By Interferon alpha-inducible protein 6 (IFI6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[214]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[215]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[216]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[217]
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[218]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]

Drug(s) Affected By Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[219]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[220]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[221]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]

Drug(s) Affected By Granulocyte colony-stimulating factor (CSF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[191]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[194]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[222]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[223]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[225]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[226]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[227]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[228]
Pomalidomide	DMTGBAX	Plasma cell myeloma	2A83.1	Approved	[229]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[230]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[231]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[232]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[192]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[233]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[194]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[205]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[234]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[235]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[205]

Drug(s) Affected By Interleukin-1 receptor antagonist protein (IL1RN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[184]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[211]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[145]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[236]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[237]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]

Drug(s) Affected By Interferon-induced GTP-binding protein Mx1 (MX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[189]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[238]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[239]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[73]

Drug(s) Affected By Fibroblast growth factor 7 (FGF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[240]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[241]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[242]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[243]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[244]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[245]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[246]

Drug(s) Affected By Fibulin-1 (FBLN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[156]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[99]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[247]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]

Drug(s) Affected By Atypical chemokine receptor 3 (ACKR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[156]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[248]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]

Drug(s) Affected By 11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[118]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[249]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[69]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[250]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[251]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[118]

Drug(s) Affected By Adenosine receptor A2a (ADORA2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[252]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[253]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[254]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[9]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]

Drug(s) Affected By Myristoylated alanine-rich C-kinase substrate (MARCKS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[255]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[256]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]

Drug(s) Affected By Guanylate-binding protein 1 (GBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[172]
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[211]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[257]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[258]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[259]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[260]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[261]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[262]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[263]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[264]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[205]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[265]

Drug(s) Affected By Thrombospondin-2 (THBS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[200]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[241]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[266]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[153]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]

Drug(s) Affected By Macrophage metalloelastase (MMP12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[139]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[145]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[9]

Drug(s) Affected By Interferon alpha-inducible protein 27, mitochondrial (IFI27)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[96]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[73]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[149]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]

Drug(s) Affected By Signal transducer and activator of transcription 1-alpha/beta (STAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[200]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[267]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[268]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[269]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[270]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[166]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[167]

Drug(s) Affected By Retinoic acid receptor responder protein 1 (RARRES1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[172]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[271]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[272]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[172]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[172]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[273]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[274]

Drug(s) Affected By Regulator of G-protein signaling 4 (RGS4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[9]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[9]

Drug(s) Affected By Spermine synthase (SMS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[150]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[275]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[9]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[9]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[276]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[277]

Drug(s) Affected By C-X-C chemokine receptor type 4 (CXCR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[172]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[106]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[278]
Carfilzomib	DM48K0X	Multiple myeloma	2A83	Approved	[279]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[280]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[281]

Drug(s) Affected By C-C motif chemokine 20 (CCL20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[191]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[194]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[222]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[282]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[162]

Drug(s) Affected By Interferon-induced 35 kDa protein (IFI35)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[283]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[99]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[149]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]

Drug(s) Affected By DNA-binding protein inhibitor ID-3 (ID3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[192]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[284]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[219]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[285]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[286]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]

Drug(s) Affected By Tumor necrosis factor alpha-induced protein 2 (TNFAIP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[283]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[287]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]

Drug(s) Affected By Aldehyde oxidase (AOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[47]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[184]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[121]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]

Drug(s) Affected By Bone marrow stromal antigen 2 (BST2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[149]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]

Drug(s) Affected By EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[241]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[211]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[273]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[9]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[288]

Drug(s) Affected By Probable ATP-dependent RNA helicase DDX10 (DDX10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[289]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[290]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[291]

Drug(s) Affected By Neuronal membrane glycoprotein M6-b (GPM6B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[292]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[293]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[9]

Drug(s) Affected By Laminin subunit beta-3 (LAMB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[294]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[248]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[295]

Drug(s) Affected By Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (ENPP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[296]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[297]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[118]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[298]

Drug(s) Affected By Nidogen-2 (NID2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[156]
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[125]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]

Drug(s) Affected By Bcl-2-related protein A1 (BCL2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[299]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[145]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[300]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[301]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[302]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[303]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[9]

Drug(s) Affected By Lymphocyte antigen 6E (LY6E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[283]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[9]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[9]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[9]

Drug(s) Affected By Interferon-induced protein 44-like (IFI44L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[167]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[150]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]

Drug(s) Affected By Collectin-12 (COLEC12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[184]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[9]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]

Drug(s) Affected By Olfactomedin-like protein 2B (OLFML2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[9]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[9]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[9]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[305]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[164]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[165]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[156]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[306]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF19B (RNF19B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[285]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[307]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]

Drug(s) Affected By Amphoterin-induced protein 2 (AMIGO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[51]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[9]

Drug(s) Affected By Probable E3 ubiquitin-protein ligase HERC6 (HERC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[211]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[113]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[9]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[9]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[291]

Drug(s) Affected By Interferon-induced protein 44 (IFI44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[186]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[239]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[149]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Bortezomib	DMNO38U	Leukemia		Approved	[308]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[9]

Drug(s) Affected By S-adenosylmethionine-dependent nucleotide dehydratase RSAD2 (RSAD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[309]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[248]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[73]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[149]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]

Drug(s) Affected By Nuclear receptor subfamily 4 group A member 3 (NR4A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[46]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[238]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[273]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[303]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]

Drug(s) Affected By Interferon regulatory factor 7 (IRF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[118]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[218]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[310]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[311]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[118]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[9]

Drug(s) Affected By Interferon-stimulated gene 20 kDa protein (ISG20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[312]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[118]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]

Drug(s) Affected By Latexin (LXN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[211]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[313]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[273]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[9]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[314]

Drug(s) Affected By Interferon-induced helicase C domain-containing protein 1 (IFIH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[102]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[315]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[9]

Drug(s) Affected By Anthrax toxin receptor 1 (ANTXR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[108]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[146]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]

Drug(s) Affected By Spondin-1 (SPON1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[292]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[316]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[317]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[164]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[67]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]

Drug(s) Affected By Interleukin-23 subunit alpha (IL23A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[318]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Misoprostol	DMHVJFK	Medical abortion	JA00.1Z	Approved	[319]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[308]
Bortezomib	DMNO38U	Leukemia		Approved	[320]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[9]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[9]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[289]

Drug(s) Affected By Matrix-remodeling-associated protein 5 (MXRA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[156]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[96]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[321]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[113]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[322]

Drug(s) Affected By NADH dehydrogenase 1 alpha subcomplex subunit 4-like 2 (NDUFA4L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[323]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[273]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[9]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[9]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[324]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[165]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[325]

Drug(s) Affected By Serine/threonine-protein phosphatase 4 regulatory subunit 2 (PPP4R2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[153]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[153]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[153]
Indomethacin	DMSC4A7	Bursitis		Approved	[326]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[9]

Drug(s) Affected By E3 ISG15--protein ligase HERC5 (HERC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[9]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[9]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[327]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[289]

Drug(s) Affected By Paired immunoglobulin-like type 2 receptor alpha (PILRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[253]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[9]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[9]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[291]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[328]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[329]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[330]

Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[205]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[205]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[205]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[331]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[332]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[205]

Drug(s) Affected By Hypoxia-inducible lipid droplet-associated protein (HILPDA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[9]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[99]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]

Drug(s) Affected By 2'-5'-oligoadenylate synthase 3 (OAS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[9]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]

Drug(s) Affected By Transcription factor E2F8 (E2F8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[99]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[292]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]

Drug(s) Affected By Odontogenic ameloblast-associated protein (ODAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[334]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[317]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]

Drug(s) Affected By UPF0524 protein C3orf70 (C3ORF70)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[125]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[290]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[335]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[165]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[325]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[156]

Drug(s) Affected By Serine/threonine-protein kinase Sgk1 (SGK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[284]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[336]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[337]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[285]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[332]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[284]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[338]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]

Drug(s) Affected By Cell division cycle 7-related protein kinase (CDC7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[339]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[340]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[341]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[342]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[289]

Drug(s) Affected By Citron Rho-interacting kinase (CIT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[290]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]

Drug(s) Affected By Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[343]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[343]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[165]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[344]
fMet-Leu-Phe	DMQ391A	N. A.	N. A.	Investigative	[345]

Drug(s) Affected By Inositol monophosphatase 2 (IMPA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[294]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[125]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[346]

Drug(s) Affected By Serine/threonine-protein kinase Chk1 (CHEK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[348]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[349]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[350]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[351]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[352]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[353]

Drug(s) Affected By Kinetochore protein NDC80 homolog (NDC80)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[354]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[106]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]

Drug(s) Affected By Aurora kinase A (AURKA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[200]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[201]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[139]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[356]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[201]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]

Drug(s) Affected By Phosphatidylinositol 4-phosphate 5-kinase type-1 beta (PIP5K1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[357]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[358]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[67]

Drug(s) Affected By Matrilin-3 (MATN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[359]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[290]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[150]

Drug(s) Affected By Mitogen-activated protein kinase 13 (MAPK13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[294]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[360]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[342]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[354]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[361]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[362]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[363]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[364]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[201]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[365]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[366]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[367]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[368]

Drug(s) Affected By Monocarboxylate transporter 7 (SLC16A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[201]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[369]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[129]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[370]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[153]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]

Drug(s) Affected By Transforming growth factor beta-1-induced transcript 1 protein (TGFB1I1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[69]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[371]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[372]

Drug(s) Affected By Protein Mis18-beta (OIP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[373]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[295]

Drug(s) Affected By Prominin-1 (PROM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[374]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[331]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[375]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[376]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[248]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[297]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[377]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]

Drug(s) Affected By Band 4.1-like protein 2 (EPB41L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[255]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[378]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[379]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[380]

Drug(s) Affected By Protein regulator of cytokinesis 1 (PRC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[264]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[381]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[153]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]

Drug(s) Affected By Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[354]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]

Drug(s) Affected By Aldo-keto reductase family 1 member B10 (AKR1B10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[116]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[118]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[382]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[383]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[384]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[248]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[124]

Drug(s) Affected By Periplakin (PPL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[274]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[385]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[386]

Drug(s) Affected By Integral membrane protein GPR137B (GPR137B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[188]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[186]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[188]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]

Drug(s) Affected By Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[354]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[387]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[191]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[388]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[389]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[390]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[391]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]

Drug(s) Affected By Hyaluronan mediated motility receptor (HMMR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[339]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[201]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[201]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]

Drug(s) Affected By Cell division control protein 45 homolog (CDC45)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[139]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[349]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[145]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]

Drug(s) Affected By Geminin (GMNN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[295]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]

Drug(s) Affected By Transcription elongation factor A protein 3 (TCEA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[290]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[385]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[392]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[393]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[164]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[198]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[388]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[394]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[108]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[395]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[396]

Drug(s) Affected By Isocitrate dehydrogenase cytoplasmic (IDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[211]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[99]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[397]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[290]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[385]

Drug(s) Affected By Cytosolic 10-formyltetrahydrofolate dehydrogenase (ALDH1L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[273]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[398]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[399]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[165]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[400]

Drug(s) Affected By Rho-related BTB domain-containing protein 1 (RHOBTB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[211]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[401]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[290]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[358]

Drug(s) Affected By Sorbin and SH3 domain-containing protein 2 (SORBS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[379]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[385]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[54]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[402]

Drug(s) Affected By Dickkopf-related protein 1 (DKK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[403]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[404]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]

Drug(s) Affected By Centrosomal protein of 152 kDa (CEP152)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[405]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[406]

Drug(s) Affected By Fibrinogen silencer-binding protein (RAD54B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[152]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[150]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[303]

Drug(s) Affected By Kinesin-like protein KIF20A (KIF20A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[200]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[285]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]

Drug(s) Affected By Structural maintenance of chromosomes protein 2 (SMC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[213]

Drug(s) Affected By Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (GCNT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[407]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[408]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[384]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[153]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[156]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[211]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[369]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[146]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[321]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[335]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]

Drug(s) Affected By Caveolae-associated protein 2 (CAVIN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[222]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[292]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]

Drug(s) Affected By Reversion-inducing cysteine-rich protein with Kazal motifs (RECK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[409]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[321]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]

Drug(s) Affected By G1/S-specific cyclin-E2 (CCNE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[354]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[285]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[47]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[340]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[410]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[411]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[153]

Drug(s) Affected By Glutamate dehydrogenase 1, mitochondrial (GLUD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[189]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[412]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[412]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]

Drug(s) Affected By Phenylalanine-4-hydroxylase (PAH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[54]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[150]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[165]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[413]

Drug(s) Affected By Haptoglobin-related protein (HPR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[47]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[273]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[130]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]

Drug(s) Affected By Metalloproteinase inhibitor 1 (TIMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pentoxifylline	DMU3DNC	Alcoholic hepatitis	DB94.1	Approved	[46]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[414]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[415]
Selenium	DM25CGV	N. A.	N. A.	Approved	[416]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[415]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[417]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[283]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[418]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[419]

Drug(s) Affected By Cystatin-A (CSTA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[420]
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[174]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[187]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[332]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[421]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[240]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[422]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[388]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[422]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[420]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[423]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[424]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[425]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[426]

Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[427]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[46]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[428]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[429]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[430]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[431]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[432]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[433]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[434]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]

Drug(s) Affected By Apolipoprotein C-III (APOC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[435]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[435]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[435]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[435]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[436]

Drug(s) Affected By Fibrinogen alpha chain (FGA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[437]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[438]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[290]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[439]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[54]

Drug(s) Affected By Angiogenin (ANG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[118]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[211]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[440]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[327]
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[441]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[442]

Drug(s) Affected By 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[443]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[444]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[445]
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[46]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[446]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[447]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[448]

Drug(s) Affected By Platelet-derived growth factor subunit A (PDGFA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[449]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[389]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[211]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[450]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]

Drug(s) Affected By Thymidine kinase, cytosolic (TK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[451]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[452]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[453]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[186]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[454]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[455]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]

Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[456]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[222]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[457]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[458]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[459]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[460]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[461]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[121]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[341]

Drug(s) Affected By Complement factor I (CFI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[211]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[294]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[462]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[439]
Fructose	DM43AN2	Vomiting	MD90	Approved	[46]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[463]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[233]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[388]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[464]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[465]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[466]

Drug(s) Affected By Thyroxine-binding globulin (SERPINA7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leuprolide	DM5XPIJ	Plasma cell myeloma	2A83.1	Approved	[46]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[467]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[468]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[54]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[393]

Drug(s) Affected By Cyclin-dependent kinase 1 (CDK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[469]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[354]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Selenium	DM25CGV	N. A.	N. A.	Approved	[470]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[364]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[471]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[389]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[139]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[340]

Drug(s) Affected By Glia-derived nexin (SERPINE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[389]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]

Drug(s) Affected By Epoxide hydrolase 1 (EPHX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[472]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[121]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[473]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[474]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]

Drug(s) Affected By Fatty acid-binding protein, liver (FABP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[199]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[475]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[199]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[199]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[199]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[476]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[202]

Drug(s) Affected By Procathepsin L (CTSL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[255]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[477]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[478]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[479]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[477]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[480]

Drug(s) Affected By Cathepsin B (CTSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[481]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[172]
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[482]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Pyrimethamine	DM5X7VY	Malaria	1F40-1F45	Approved	[483]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[484]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[485]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[486]

Drug(s) Affected By DNA excision repair protein ERCC-1 (ERCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[99]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[150]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[487]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[488]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[489]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[490]

Drug(s) Affected By Rho-related GTP-binding protein RhoC (RHOC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[491]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[492]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[396]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[493]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]

Drug(s) Affected By Amino acid transporter heavy chain SLC3A2 (SLC3A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[201]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[369]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[332]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[332]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[153]

Drug(s) Affected By Stromelysin-1 (MMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[46]
Fluvastatin	DM4MDJY	Arteriosclerosis	BD40	Approved	[46]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[46]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[46]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[214]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[222]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[494]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[495]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[496]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[497]

Drug(s) Affected By Monocyte differentiation antigen CD14 (CD14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[388]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[498]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[108]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[499]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[500]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[501]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]

Drug(s) Affected By Interleukin-6 receptor subunit alpha (IL6R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[502]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[503]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[146]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[504]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[505]
Mebendazole	DMO14SG	Ascariasis	1F62	Approved	[504]

Drug(s) Affected By Glycodelin (PAEP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[245]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[506]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[507]

Drug(s) Affected By DNA polymerase alpha catalytic subunit (POLA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[241]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[508]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[509]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[510]

Drug(s) Affected By Histone H2A.Z (H2AZ1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[511]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[512]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[513]
Fenretinide	DMRD5SP	Macular degeneration	9B78.3	Phase 3	[514]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[512]

Drug(s) Affected By Myb-related protein A (MYBL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[284]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[337]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[515]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[284]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[396]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[125]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[337]

Drug(s) Affected By E3 SUMO-protein ligase EGR2 (EGR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[145]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[308]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 2 (SLC2A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[516]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[339]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[47]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[517]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[518]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]

Drug(s) Affected By Mannose-binding protein C (MBL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[118]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[118]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[54]
Bortezomib	DMNO38U	Leukemia		Approved	[519]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[165]

Drug(s) Affected By Serine/threonine-protein kinase pim-1 (PIM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[194]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[520]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[283]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[508]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[521]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]

Drug(s) Affected By DNA topoisomerase 2-alpha (TOP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[522]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[523]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[464]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[524]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[525]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[283]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[526]

Drug(s) Affected By Proliferating cell nuclear antigen (PCNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[191]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[420]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[339]
Selenium	DM25CGV	N. A.	N. A.	Approved	[470]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[446]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[527]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[528]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[389]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[139]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[529]

Drug(s) Affected By Creatine kinase B-type (CKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[264]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[530]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[531]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]

Drug(s) Affected By Interleukin-7 (IL7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[532]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[226]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[226]
Oxymetholone	DMFXUT8	Aplastic anemia	3A70	Approved	[533]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[534]

Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[469]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[464]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Selenium	DM25CGV	N. A.	N. A.	Approved	[470]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[364]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[535]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[536]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[201]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]

Drug(s) Affected By Leukemia inhibitory factor (LIF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[191]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[389]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[186]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[537]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[248]

Drug(s) Affected By Fos-related antigen 1 (FOSL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[222]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[121]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[508]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[294]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[538]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[539]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[279]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[540]
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[541]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[542]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[543]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[331]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[544]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[525]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[545]

Drug(s) Affected By Stathmin (STMN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[388]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[200]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[546]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[547]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[187]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[548]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]

Drug(s) Affected By Insulin-like growth factor-binding protein 3 (IGFBP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[156]
Selenium	DM25CGV	N. A.	N. A.	Approved	[549]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[174]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[550]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[407]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[551]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[552]

Drug(s) Affected By Early growth response protein 1 (EGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[198]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[47]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[270]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[553]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[554]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[555]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[188]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[556]

Drug(s) Affected By Hexokinase-1 (HK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Mebendazole	DMO14SG	Ascariasis	1F62	Approved	[557]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[290]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[558]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[83]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[46]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[428]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[559]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[47]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[349]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[560]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[561]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[562]

Drug(s) Affected By Transcription factor E3 (TFE3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[238]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[153]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[153]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[289]

Drug(s) Affected By Neutrophil cytosol factor 2 (NCF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[186]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[563]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[248]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[564]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]

Drug(s) Affected By Follistatin (FST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[194]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[394]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[565]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]

Drug(s) Affected By Cyclin-A2 (CCNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[566]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[469]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[420]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[527]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[567]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[139]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[568]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]

Drug(s) Affected By Lamin-B1 (LMNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[569]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[268]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[570]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[283]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[69]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]

Drug(s) Affected By Aromatic-L-amino-acid decarboxylase (DDC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[571]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[99]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[572]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[573]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[62]

Drug(s) Affected By Interleukin-11 (IL11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[222]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[574]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[575]

Drug(s) Affected By Ribonucleoside-diphosphate reductase large subunit (RRM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[576]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[200]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[455]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[295]

Drug(s) Affected By COUP transcription factor 2 (NR2F2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[283]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[577]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]

Drug(s) Affected By DNA replication licensing factor MCM3 (MCM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[349]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[508]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[539]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]

Drug(s) Affected By High mobility group protein B2 (HMGB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[240]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[339]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[186]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[578]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[411]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]

Drug(s) Affected By Deoxycytidine kinase (DCK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[187]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Emtricitabine	DMBMUWZ	Hepatitis virus infection	1E50-1E51	Approved	[579]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[289]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
DEOXYCYTIDINE	DMYE5LJ	Acute myeloid leukaemia	2A60	Approved	[579]

Drug(s) Affected By Proteasome subunit beta type-9 (PSMB9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[580]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[283]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[315]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[113]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[581]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[580]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[385]

Drug(s) Affected By Dual specificity protein phosphatase 1 (DUSP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[191]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[388]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[582]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[583]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[186]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[508]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[395]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]

Drug(s) Affected By Grancalcin (GCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[47]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[283]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[373]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[393]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[317]

Drug(s) Affected By M-phase inducer phosphatase 1 (CDC25A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[423]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[285]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[348]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[584]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[585]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[561]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[586]

Drug(s) Affected By M-phase inducer phosphatase 3 (CDC25C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[423]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[389]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[587]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[588]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]

Drug(s) Affected By Ribonucleoside-diphosphate reductase subunit M2 (RRM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[576]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[283]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[292]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[539]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]

Drug(s) Affected By Sodium- and chloride-dependent taurine transporter (SLC6A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[211]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[153]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[378]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[379]

Drug(s) Affected By 14-3-3 protein sigma (SFN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[216]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[174]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[188]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[390]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[188]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[130]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[589]

Drug(s) Affected By Protein S100-A11 (S100A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[238]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[396]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[590]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]

Drug(s) Affected By Dual specificity protein kinase TTK (TTK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[354]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]

Drug(s) Affected By DNA replication licensing factor MCM4 (MCM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[423]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[139]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[349]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[591]

Drug(s) Affected By DNA replication licensing factor MCM5 (MCM5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[186]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[508]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[292]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]

Drug(s) Affected By Ribonuclease 4 (RNASE4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[118]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[211]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[274]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[385]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[54]

Drug(s) Affected By Serine hydroxymethyltransferase, cytosolic (SHMT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[99]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[592]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[321]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[342]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[593]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]

Drug(s) Affected By Pro-adrenomedullin (ADM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[240]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[394]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[160]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[248]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[594]

Drug(s) Affected By Sodium channel protein type 1 subunit alpha (SCN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[595]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[596]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[156]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[290]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[54]

Drug(s) Affected By Phosphoenolpyruvate carboxykinase, cytosolic (PCK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[223]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[597]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[537]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[370]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[198]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[598]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[388]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[599]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[435]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[600]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[601]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]

Drug(s) Affected By Glutaredoxin-1 (GLRX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[283]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[275]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[602]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[410]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[240]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[464]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[361]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[603]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[364]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[604]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[535]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[285]

Drug(s) Affected By Flap endonuclease 1 (FEN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[191]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[295]

Drug(s) Affected By Pre-B-cell leukemia transcription factor 3 (PBX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[156]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[150]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Bortezomib	DMNO38U	Leukemia		Approved	[308]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[605]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]

Drug(s) Affected By Replication factor C subunit 5 (RFC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[139]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[283]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[295]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[213]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[360]

Drug(s) Affected By Replication factor C subunit 3 (RFC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]

Drug(s) Affected By Lamina-associated polypeptide 2, isoform alpha (TMPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[200]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[413]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[283]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[292]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]

Drug(s) Affected By Cyclin-dependent kinase 4 inhibitor B (CDKN2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[606]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[423]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[604]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[607]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[608]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]

Drug(s) Affected By DNA mismatch repair protein Msh2 (MSH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[609]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[508]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[610]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]

Drug(s) Affected By Lysophosphatidic acid receptor 6 (LPAR6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[396]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[602]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[290]

Drug(s) Affected By Proliferation marker protein Ki-67 (MKI67)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[611]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[413]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[186]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[612]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[508]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[613]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[614]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]

Drug(s) Affected By Radiation-inducible immediate-early gene IEX-1 (IER3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[191]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[423]
Selenium	DM25CGV	N. A.	N. A.	Approved	[180]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[283]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[332]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[99]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]

Drug(s) Affected By Microtubule-associated protein 1B (MAP1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[481]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[615]

Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[197]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[116]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[616]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[617]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[618]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[592]

Drug(s) Affected By Nuclear autoantigenic sperm protein (NASP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[619]

Drug(s) Affected By Flavin-containing monooxygenase 5 (FMO5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[553]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[554]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[118]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[118]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]

Drug(s) Affected By Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[292]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[620]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]

Drug(s) Affected By Histone H3-like centromeric protein A (CENPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[200]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[411]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]

Drug(s) Affected By Centromere protein F (CENPF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[621]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]

Drug(s) Affected By DNA primase small subunit (PRIM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[139]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]

Drug(s) Affected By DNA replication licensing factor MCM2 (MCM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[191]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[349]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[186]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[341]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[622]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]

Drug(s) Affected By Type I iodothyronine deiodinase (DIO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[485]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[253]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Ergocalciferol	DMHO0AR	Hypoparathyroidism	5A50	Approved	[623]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[624]
Masoprocol	DMMVNZ0	Prostate cancer	2C82.0	Approved	[623]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[625]
Oxytetracycline	DMOVH1M	Actinomycosis		Approved	[626]

Drug(s) Affected By Kinetochore-associated protein 1 (KNTC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[615]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF144A (RNF144A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[146]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[442]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[627]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[378]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[165]

Drug(s) Affected By DNA replication ATP-dependent helicase/nuclease DNA2 (DNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[290]

Drug(s) Affected By Breast cancer type 2 susceptibility protein (BRCA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[566]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[270]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[283]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[160]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]

Drug(s) Affected By Aldo-keto reductase family 1 member D1 (AKR1D1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[54]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[63]

Drug(s) Affected By Serine/threonine-protein kinase Nek2 (NEK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[354]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[339]
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[583]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[292]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[628]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[629]

Drug(s) Affected By DNA mismatch repair protein Msh6 (MSH6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[285]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[283]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]

Drug(s) Affected By Kinesin-like protein KIF11 (KIF11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[295]

Drug(s) Affected By 2-iminobutanoate/2-iminopropanoate deaminase (RIDA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[630]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[329]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[325]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[631]

Drug(s) Affected By Hexokinase-2 (HK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[529]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[632]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[633]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[634]

Drug(s) Affected By Thimet oligopeptidase (THOP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[635]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[636]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[406]

Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[637]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[638]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[639]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[637]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[408]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[637]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[242]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]

Drug(s) Affected By Epithelial membrane protein 3 (EMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[188]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[188]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]

Drug(s) Affected By Delta-1-pyrroline-5-carboxylate synthase (ALDH18A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]
Haloperidol	DM96SE0	Delirium		Approved	[213]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[153]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[153]
Bortezomib	DMNO38U	Leukemia		Approved	[308]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]

Drug(s) Affected By Hepatocyte nuclear factor 3-alpha (FOXA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[172]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[264]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[640]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[641]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]

Drug(s) Affected By DNA polymerase epsilon subunit 2 (POLE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]

Drug(s) Affected By Breast cancer anti-estrogen resistance protein 1 (BCAR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[264]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[213]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[213]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[290]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[264]

Drug(s) Affected By Sestrin-2 (SESN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[198]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[234]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[332]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[332]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[411]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[198]

Drug(s) Affected By Anthrax toxin receptor 2 (ANTXR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[290]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[385]

Drug(s) Affected By Protein FAM3B (FAM3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[290]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[291]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[150]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[165]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[344]

Drug(s) Affected By Histone H2B type 1-D (H2BC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[339]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[99]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[247]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[297]

Drug(s) Affected By Lysozyme C (LYZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[217]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[218]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[396]
Glibenclamide	DM8JXPZ	Diabetic complication	5A2Y	Approved	[642]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[643]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[644]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]

Drug(s) Affected By Histone H3.1 (H3C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[191]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[292]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[411]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[248]

Drug(s) Affected By Gamma-aminobutyric acid receptor subunit epsilon (GABRE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[108]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[273]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[645]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[646]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[647]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[165]

Drug(s) Affected By Iroquois-class homeodomain protein IRX-3 (IRX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[187]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[113]

Drug(s) Affected By Protein jagged-1 (JAG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[174]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[218]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[404]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[150]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[648]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]

Drug(s) Affected By 11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[649]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[650]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[651]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[652]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[653]
Oxymetholone	DMFXUT8	Aplastic anemia	3A70	Approved	[654]

Drug(s) Affected By Centromere-associated protein E (CENPE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[217]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[295]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]

Drug(s) Affected By Kinesin-like protein KIF23 (KIF23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[655]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]

Drug(s) Affected By Cyclic AMP-responsive element-binding protein 5 (CREB5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[102]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[656]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[248]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[297]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[379]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[303]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]

Drug(s) Affected By Hematopoietically-expressed homeobox protein HHEX (HHEX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[218]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[396]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[657]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[658]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[67]

Drug(s) Affected By Transforming growth factor beta receptor type 3 (TGFBR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[171]
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[292]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[628]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[401]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]

Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[659]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[637]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[638]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[660]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[637]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[637]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[139]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[661]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[660]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[637]

Drug(s) Affected By Max dimerization protein 1 (MXD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[389]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[662]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[391]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[184]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[586]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]

Drug(s) Affected By Forkhead box protein M1 (FOXM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[354]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[292]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[539]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[663]

Drug(s) Affected By Peroxisomal bifunctional enzyme (EHHADH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[664]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[664]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[665]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[666]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[664]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]

Drug(s) Affected By Putative sodium-coupled neutral amino acid transporter 11 (SLC38A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[644]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[54]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[373]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[667]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[165]

Drug(s) Affected By TBC1 domain family member 8B (TBC1D8B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[152]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[213]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[385]

Drug(s) Affected By Coiled-coil domain-containing protein 15 (CCDC15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[315]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[289]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[373]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[317]

Drug(s) Affected By Cell division cycle protein 20 homolog (CDC20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[354]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[423]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[668]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]

Drug(s) Affected By Dihydropyrimidine dehydrogenase (DPYD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[669]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[670]
Tegafur	DM31ZQM	Solid tumour/cancer	2A00-2F9Z	Approved	[671]
Flucytosine	DM13VTW	Cryptococcal meningitis		Approved	[46]
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]

Drug(s) Affected By Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[354]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[139]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[241]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[672]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]

Drug(s) Affected By Syntaxin-3 (STX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[321]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[118]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[401]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]

Drug(s) Affected By S-phase kinase-associated protein 2 (SKP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[191]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[673]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[283]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[455]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]

Drug(s) Affected By Growth factor receptor-bound protein 10 (GRB10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[156]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[201]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[166]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]

Drug(s) Affected By Origin recognition complex subunit 1 (ORC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[191]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[508]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[591]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[674]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[428]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[675]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[676]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[217]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[677]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[201]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[389]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[218]

Drug(s) Affected By Transformer-2 protein homolog alpha (TRA2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[213]
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[102]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[678]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]

Drug(s) Affected By Four and a half LIM domains protein 3 (FHL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[289]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[602]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[329]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[325]

Drug(s) Affected By Krueppel-like factor 5 (KLF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[201]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[102]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[248]

Drug(s) Affected By Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[309]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[447]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[332]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[99]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]

Drug(s) Affected By Transcription factor Dp-1 (TFDP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[349]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[283]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[508]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[341]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[154]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Bortezomib	DMNO38U	Leukemia		Approved	[308]

Drug(s) Affected By Glucokinase regulatory protein (GCKR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[329]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[344]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[679]
OXYQUINOLINE	DMZVS9Y	Discovery agent	N.A.	Investigative	[92]

Drug(s) Affected By Growth factor receptor-bound protein 14 (GRB14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[241]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[146]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[290]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[385]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[215]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[398]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[83]

Drug(s) Affected By Histone RNA hairpin-binding protein (SLBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[156]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[339]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[285]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[285]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[285]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[285]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[285]

Drug(s) Affected By Squalene monooxygenase (SQLE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[680]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[447]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[118]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[672]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[125]

Drug(s) Affected By DNA replication licensing factor MCM6 (MCM6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[349]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[189]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[539]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]

Drug(s) Affected By Separin (ESPL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[354]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[321]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]

Drug(s) Affected By Maternal embryonic leucine zipper kinase (MELK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[295]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]

Drug(s) Affected By DNA replication complex GINS protein PSF1 (GINS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[240]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[99]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[401]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]

Drug(s) Affected By Prostaglandin reductase 1 (PTGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[681]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[125]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]

Drug(s) Affected By Condensin complex subunit 2 (NCAPH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[200]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[145]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Haloperidol	DM96SE0	Delirium		Approved	[213]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[591]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]

Drug(s) Affected By PCNA-associated factor (PCLAF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[200]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[253]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[539]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[295]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]

Drug(s) Affected By DNA polymerase delta subunit 3 (POLD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[289]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[380]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]

Drug(s) Affected By Transcription elongation factor A protein-like 1 (TCEAL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Bortezomib	DMNO38U	Leukemia		Approved	[320]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[289]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[682]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[221]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[165]

Drug(s) Affected By Transcription factor E2F5 (E2F5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[341]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[154]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[683]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[342]

Drug(s) Affected By Disks large-associated protein 5 (DLGAP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[153]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[153]

Drug(s) Affected By SH2 domain-containing adapter protein B (SHB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[47]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[464]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[164]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]

Drug(s) Affected By SCL-interrupting locus protein (STIL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[295]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[406]

Drug(s) Affected By Pachytene checkpoint protein 2 homolog (TRIP13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[591]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[125]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]

Drug(s) Affected By High mobility group nucleosome-binding domain-containing protein 3 (HMGN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[380]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[684]

Drug(s) Affected By Methylsterol monooxygenase 1 (MSMO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[447]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[218]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[99]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[218]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]

Drug(s) Affected By Histone-lysine N-methyltransferase EZH2 (EZH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[543]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[413]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[685]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[686]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[687]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]

Drug(s) Affected By C-C motif chemokine 15 (CCL15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[54]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[165]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[688]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 3 (CDKN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]

Drug(s) Affected By Dual specificity protein phosphatase 5 (DUSP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[191]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[394]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[689]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[153]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]

Drug(s) Affected By Kynureninase (KYNU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[284]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[186]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[284]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[102]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]

Drug(s) Affected By Histone H2B type 2-E (H2BC21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[186]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[99]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[401]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[113]

Drug(s) Affected By Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HADH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[99]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[436]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[323]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]

Drug(s) Affected By Cytoplasmic polyadenylation element-binding protein 4 (CPEB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[539]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[690]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[385]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[393]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[83]

Drug(s) Affected By Sodium/glucose cotransporter 4 (SLC5A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[329]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[344]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[679]

Drug(s) Affected By Autophagy-related protein 2 homolog A (ATG2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[372]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[691]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[413]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[692]

Drug(s) Affected By Protein FAM161A (FAM161A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[693]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[694]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[695]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[636]

Drug(s) Affected By Renal cancer differentiation gene 1 protein (C4ORF46)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[291]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[406]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[696]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]

Drug(s) Affected By Centrosomal protein of 55 kDa (CEP55)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[295]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[359]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]

Drug(s) Affected By Pleckstrin homology-like domain family A member 2 (PHLDA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[211]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[255]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[99]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]

Drug(s) Affected By Borealin (CDCA8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[591]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[295]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[674]

Drug(s) Affected By Shugoshin 2 (SGO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]

Drug(s) Affected By Spindlin-4 (SPIN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[406]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[317]

Drug(s) Affected By N-acetyltransferase ESCO2 (ESCO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[308]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[289]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[697]

Drug(s) Affected By Transmembrane protein 170B (TMEM170B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[273]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[289]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[684]

Drug(s) Affected By KN motif and ankyrin repeat domain-containing protein 4 (KANK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[292]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[327]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[327]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[150]

Drug(s) Affected By Immediate early response gene 5-like protein (IER5L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[248]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[401]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[273]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[379]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[684]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[698]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[373]

Drug(s) Affected By Coiled-coil domain-containing protein 18 (CCDC18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[699]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]

Drug(s) Affected By DEP domain-containing protein 1A (DEPDC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[292]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]

Drug(s) Affected By PX domain-containing protein 1 (PXDC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[700]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Indomethacin	DMSC4A7	Bursitis		Approved	[326]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[150]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]

Drug(s) Affected By Mitochondrial amidoxime-reducing component 1 (MTARC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[701]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[355]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[558]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[402]

Drug(s) Affected By Interleukin-1 receptor-associated kinase 1-binding protein 1 (IRAK1BP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[54]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[325]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[702]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[150]
RESORCINOL	DMM37C0	Discovery agent	N.A.	Investigative	[8]
OXYQUINOLINE	DMZVS9Y	Discovery agent	N.A.	Investigative	[92]

Drug(s) Affected By Immediate early response gene 5 protein (IER5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[188]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[188]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[188]

Drug(s) Affected By Meteorin-like protein (METRNL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[156]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[248]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]

Drug(s) Affected By Protein sel-1 homolog 3 (SEL1L3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[292]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[703]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[273]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[289]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]

Drug(s) Affected By Cell division cycle-associated protein 2 (CDCA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[129]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[411]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[591]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]

Drug(s) Affected By Transcription factor Sp5 (SP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[297]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[62]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[150]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[83]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]

Drug(s) Affected By Phostensin (PPP1R18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[156]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[248]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[327]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[327]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[385]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[704]

Drug(s) Affected By Mis18-binding protein 1 (MIS18BP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[373]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[695]

Drug(s) Affected By Mitochondrial fission regulator 2 (MTFR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]

Drug(s) Affected By Rho GTPase-activating protein 11A (ARHGAP11A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[697]

Drug(s) Affected By Proline/serine-rich coiled-coil protein 1 (PSRC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[411]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[295]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[308]

Drug(s) Affected By Protein aurora borealis (BORA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[240]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[411]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[248]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[295]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[381]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]

Drug(s) Affected By ATPase family AAA domain-containing protein 2 (ATAD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[186]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[705]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[153]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[373]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[153]

Drug(s) Affected By Serine protease FAM111B (FAM111B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[191]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[674]

Drug(s) Affected By HHIP-like protein 2 (HHIPL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[294]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[358]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[706]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[165]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[706]

Drug(s) Affected By Nephronectin (NPNT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[290]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[605]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]

Drug(s) Affected By Calcium/manganese antiporter SLC30A10 (SLC30A10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[99]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[100]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[707]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[54]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[150]

Drug(s) Affected By Hydroxysteroid dehydrogenase-like protein 2 (HSDL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[315]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[700]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[558]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[67]

Drug(s) Affected By Lysosomal amino acid transporter 1 homolog (SLC66A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[289]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[290]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[385]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[97]

Drug(s) Affected By Solute carrier organic anion transporter family member 4C1 (SLCO4C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[99]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[644]

Drug(s) Affected By RNA-binding protein with multiple splicing 2 (RBPMS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[684]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[373]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[708]

Drug(s) Affected By Rho GTPase-activating protein 27 (ARHGAP27)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[709]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[328]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[165]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[325]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[710]

Drug(s) Affected By SH2 domain-containing protein 5 (SH2D5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[355]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[335]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[697]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[373]

Drug(s) Affected By Vesicle transport protein GOT1A (GOLT1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[711]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[165]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[344]

Drug(s) Affected By Membrane progestin receptor epsilon (PAQR9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[385]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[83]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[165]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[325]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[712]

Drug(s) Affected By Centromere protein U (CENPU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[401]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]

Drug(s) Affected By Histone H2A.V (H2AZ2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[321]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[713]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[83]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[67]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[714]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[695]

Drug(s) Affected By Carbohydrate sulfotransferase 9 (CHST9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[150]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[393]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[150]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[165]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[208]

Drug(s) Affected By Protein MCM10 homolog (MCM10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[285]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[186]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[591]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[295]

Drug(s) Affected By Transmembrane channel-like protein 7 (TMC7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[297]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[83]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[165]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[413]

Drug(s) Affected By Transmembrane channel-like protein 6 (TMC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[283]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[715]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[401]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]

Drug(s) Affected By Low-density lipoprotein receptor-related protein 10 (LRP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[716]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[401]

Drug(s) Affected By HAUS augmin-like complex subunit 6 (HAUS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[391]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Bortezomib	DMNO38U	Leukemia		Approved	[308]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[699]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]

Drug(s) Affected By Protein O-glucosyltransferase 3 (POGLUT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[403]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[289]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[385]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[329]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[325]

Drug(s) Affected By E3 ubiquitin-protein ligase SH3RF1 (SH3RF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[315]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[290]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[682]

Drug(s) Affected By Uncharacterized protein C11orf96 (C11ORF96)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[240]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[156]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[248]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[327]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[150]

Drug(s) Affected By Retrotransposon-derived protein PEG10 (PEG10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[118]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[186]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[219]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[717]

Drug(s) Affected By Suppressor APC domain-containing protein 2 (SAPCD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[292]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[295]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[327]

Drug(s) Affected By Condensin-2 complex subunit G2 (NCAPG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[219]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[295]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]

Drug(s) Affected By GAS2-like protein 3 (GAS2L3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[113]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]

Drug(s) Affected By Cilium assembly protein DZIP1 (DZIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[156]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[255]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[290]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[67]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[67]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[165]

Drug(s) Affected By Rab11 family-interacting protein 4 (RAB11FIP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[62]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[164]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[150]

Drug(s) Affected By Inactive tyrosine-protein kinase PRAG1 (PRAG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[248]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[289]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[290]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[693]

Drug(s) Affected By Transmembrane channel-like protein 8 (TMC8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[690]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[291]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[328]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[165]
2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE	DMNQL17	Discovery agent	N.A.	Investigative	[718]

Drug(s) Affected By Leucine rich adaptor protein 1-like (LURAP1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[191]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[591]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[691]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[54]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[164]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]

Drug(s) Affected By Immunoglobulin superfamily DCC subclass member 3 (IGDCC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[406]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[54]

Drug(s) Affected By Inositol 1,4,5-trisphosphate receptor-interacting protein (ITPRIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[289]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[719]

Drug(s) Affected By Volume-regulated anion channel subunit LRRC8A (LRRC8A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[118]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[373]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[83]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[97]

Drug(s) Affected By Protein FAM200C (FAM200C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[332]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[291]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[335]

Drug(s) Affected By Solute carrier family 22 member 15 (SLC22A15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[369]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[292]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[92]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[273]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]

Drug(s) Affected By Abnormal spindle-like microcephaly-associated protein (ASPM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[219]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[655]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]

Drug(s) Affected By EP300-interacting inhibitor of differentiation 3 (EID3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[54]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[165]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[325]

Drug(s) Affected By N-acetylglutamate synthase, mitochondrial (NAGS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[125]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[558]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[373]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[667]

Drug(s) Affected By Protein FAM43A (FAM43A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[192]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[401]

Drug(s) Affected By Mucin-20 (MUC20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[211]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[321]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[385]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[373]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[165]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[631]
cordycepin	DM72Y01	Discovery agent	N.A.	Investigative	[720]

Drug(s) Affected By Choline transporter-like protein 3 (SLC44A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[164]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[150]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[373]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[721]

Drug(s) Affected By Testis-expressed protein 9 (TEX9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[152]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[697]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[150]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[208]
OXYQUINOLINE	DMZVS9Y	Discovery agent	N.A.	Investigative	[92]

Drug(s) Affected By Mixed lineage kinase domain-like protein (MLKL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[121]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[722]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[723]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[118]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[327]

Drug(s) Affected By Golgi membrane protein 1 (GOLM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[358]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[165]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[724]

Drug(s) Affected By Aquaporin-11 (AQP11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[297]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[289]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[62]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[393]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[83]

Drug(s) Affected By Uncharacterized protein C1orf131 (C1ORF131)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[385]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[725]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[692]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[726]

Drug(s) Affected By Meiosis-specific nuclear structural protein 1 (MNS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[289]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[54]

Drug(s) Affected By SHC SH2 domain-binding protein 1 (SHCBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[339]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]

Drug(s) Affected By Methylcytosine dioxygenase TET1 (TET1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[727]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[47]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[728]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[303]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[728]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[83]

Drug(s) Affected By V-type proton ATPase subunit e 2 (ATP6V0E2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[329]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[156]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[729]

Drug(s) Affected By Kinesin-like protein KIF18A (KIF18A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[411]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]

Drug(s) Affected By (Lyso)-N-acylphosphatidylethanolamine lipase (ABHD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[153]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[153]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[153]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[730]

Drug(s) Affected By Arrestin domain-containing protein 2 (ARRDC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[401]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[327]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[327]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[62]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[731]

Drug(s) Affected By Nuclear protein MDM1 (MDM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[283]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[321]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[289]

Drug(s) Affected By Pantothenate kinase 1 (PANK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[153]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[153]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[118]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]

Drug(s) Affected By 2-phosphoxylose phosphatase 1 (PXYLP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[62]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[385]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[83]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]

Drug(s) Affected By Rhomboid-related protein 4 (RHBDD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Indomethacin	DMSC4A7	Bursitis		Approved	[732]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[290]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[291]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[733]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[156]

Drug(s) Affected By Centrosomal protein of 192 kDa (CEP192)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[51]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[733]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[413]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[406]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[726]

Drug(s) Affected By PDZ domain-containing protein GIPC2 (GIPC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[54]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[54]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[413]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[344]

Drug(s) Affected By Monocarboxylate transporter 10 (SLC16A10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[54]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[373]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[164]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]

Drug(s) Affected By Glycerophosphodiester phosphodiesterase domain-containing protein 5 (GDPD5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[401]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[378]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[355]

Drug(s) Affected By Sodium-dependent phosphate transporter 1 (SLC20A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phosphate	DMUXQG7	Constipation	DD91.1	Approved	[734]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[218]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[369]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[735]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]

Drug(s) Affected By DEP domain-containing protein 1B (DEPDC1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[373]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[295]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]

Drug(s) Affected By Kelch repeat and BTB domain-containing protein 7 (KBTBD7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[327]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[327]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[83]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]

Drug(s) Affected By Cytoskeleton-associated protein 2 (CKAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[339]
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]

Drug(s) Affected By Palladin (PALLD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[191]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[47]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[73]

Drug(s) Affected By Ras and Rab interactor 2 (RIN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[321]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[736]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[385]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[335]

Drug(s) Affected By Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 (ARAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[152]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]

Drug(s) Affected By Aquaporin-3 (AQP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[737]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[517]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[92]

Drug(s) Affected By Protein NDRG1 (NDRG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[195]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[738]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[471]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[309]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[218]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[125]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[401]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]

Drug(s) Affected By Gamma-glutamyl hydrolase (GGH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[739]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[740]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[339]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[391]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[275]

Drug(s) Affected By ATP-binding cassette sub-family C member 2 (ABCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lopinavir	DMITQS0	Human immunodeficiency virus infection	1C62	Approved	[741]
Sulfinpyrazone	DMEV954	Gout	FA25	Approved	[742]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[743]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[744]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[739]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[517]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[745]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[746]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[747]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[385]

Drug(s) Affected By GTP-binding protein Rit1 (RIT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[153]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[248]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[153]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[153]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[275]
Bortezomib	DMNO38U	Leukemia		Approved	[308]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]

Drug(s) Affected By Liver-expressed antimicrobial peptide 2 (LEAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[748]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[118]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[749]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[385]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[54]

Drug(s) Affected By Protein MAL2 (MAL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[750]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[385]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[83]

Drug(s) Affected By SOSS complex subunit B2 (NABP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[248]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]

Drug(s) Affected By Transcription factor E2F7 (E2F7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[401]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]

Drug(s) Affected By RAD51-associated protein 1 (RAD51AP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[172]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[295]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]

Drug(s) Affected By SPRY domain-containing SOCS box protein 1 (SPSB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[248]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[153]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[153]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[627]

Drug(s) Affected By Spindle and kinetochore-associated protein 1 (SKA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[186]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[289]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[290]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]

Drug(s) Affected By Solute carrier family 22 member 18 (SLC22A18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[211]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[369]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[99]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]

Drug(s) Affected By Endoplasmic reticulum resident protein 27 (ERP27)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[118]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[211]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[118]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[378]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[379]

Drug(s) Affected By Ankyrin repeat and SOCS box protein 9 (ASB9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[172]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[150]

Drug(s) Affected By RecQ-mediated genome instability protein 2 (RMI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[289]

Drug(s) Affected By Protein Spindly (SPDL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]

Drug(s) Affected By Sororin (CDCA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[125]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[295]

Drug(s) Affected By Aurora kinase B (AURKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[240]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[354]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[536]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[186]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[153]

Drug(s) Affected By Cell division cycle-associated 7-like protein (CDCA7L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[187]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[290]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[164]

Drug(s) Affected By Serine/threonine-protein kinase greatwall (MASTL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[240]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[289]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[324]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]

Drug(s) Affected By Coiled-coil domain-containing protein 34 (CCDC34)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[339]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[373]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[721]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[751]

Drug(s) Affected By Carboxypeptidase B2 (CPB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[752]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[753]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[754]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[393]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[667]

Drug(s) Affected By Lymphokine-activated killer T-cell-originated protein kinase (PBK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[499]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]

Drug(s) Affected By Leucine-rich repeat protein 1 (LRR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[406]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[630]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[696]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[329]

Drug(s) Affected By Coiled-coil domain-containing protein 138 (CCDC138)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[308]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[329]

Drug(s) Affected By Uncharacterized protein C5orf34 (C5ORF34)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[240]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[113]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]

Drug(s) Affected By Transmembrane protein 237 (TMEM237)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[248]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[619]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Indomethacin	DMSC4A7	Bursitis		Approved	[326]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[62]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[325]

Drug(s) Affected By Kinesin-like protein KIF20B (KIF20B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[241]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[201]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[755]

Drug(s) Affected By Sperm-associated antigen 5 (SPAG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]

Drug(s) Affected By PAS domain-containing serine/threonine-protein kinase (PASK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[83]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[329]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[325]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[413]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[156]

Drug(s) Affected By Tribbles homolog 3 (TRIB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[198]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[118]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[211]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[332]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[129]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[130]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[332]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[395]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]

Drug(s) Affected By Tribbles homolog 1 (TRIB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[191]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]

Drug(s) Affected By Serine incorporator 2 (SERINC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[321]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[118]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[751]

Drug(s) Affected By Cytochrome P450 2S1 (CYP2S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[756]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[315]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[757]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[757]

Drug(s) Affected By Krueppel-like factor 6 (KLF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[191]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[758]
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[285]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[139]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]

Drug(s) Affected By Cell division cycle-associated protein 3 (CDCA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[186]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[591]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[295]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]

Drug(s) Affected By Kinesin-like protein KIF2C (KIF2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[759]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[186]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[295]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]

Drug(s) Affected By BRCA1-associated RING domain protein 1 (BARD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[760]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[295]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]

Drug(s) Affected By Cell division control protein 6 homolog (CDC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[285]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[139]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[241]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[283]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[585]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]

Drug(s) Affected By Growth/differentiation factor 15 (GDF15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[198]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[285]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[201]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[241]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[761]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[762]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[169]

Drug(s) Affected By Condensin complex subunit 3 (NCAPG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[295]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]

Drug(s) Affected By SMC5-SMC6 complex localization factor protein 1 (SLF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[290]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[695]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[165]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[325]

Drug(s) Affected By Coiled-coil domain-containing protein 77 (CCDC77)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[335]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[83]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[695]

Drug(s) Affected By DNA replication complex GINS protein PSF3 (GINS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[401]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[289]

Drug(s) Affected By Centromere protein K (CENPK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]

Drug(s) Affected By RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 (RHNO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[113]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[406]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[329]

Drug(s) Affected By Protein PIMREG (PIMREG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[295]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[62]

Drug(s) Affected By Immediate early response gene 2 protein (IER2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[47]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[763]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[396]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[293]

Drug(s) Affected By EF-hand calcium-binding domain-containing protein 11 (EFCAB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[764]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[733]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[325]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[156]

Drug(s) Affected By Sister chromatid cohesion protein DCC1 (DSCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[191]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[289]

Drug(s) Affected By Acetyl-CoA acetyltransferase, cytosolic (ACAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[99]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[125]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[765]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[701]

Drug(s) Affected By Cell division cycle-associated protein 7 (CDCA7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[211]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[766]

Drug(s) Affected By Meiotic nuclear division protein 1 homolog (MND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[187]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[292]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[289]

Drug(s) Affected By RNA-binding protein 24 (RBM24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[378]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[379]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[303]

Drug(s) Affected By Nucleolar and spindle-associated protein 1 (NUSAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[186]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[539]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]

Drug(s) Affected By Cell adhesion molecule 1 (CADM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[47]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[283]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[672]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[767]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[768]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]

Drug(s) Affected By Sulfiredoxin-1 (SRXN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[383]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[769]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[332]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[153]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[153]

Drug(s) Affected By Kinetochore protein Nuf2 (NUF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[240]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[339]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]

Drug(s) Affected By Protein sprouty homolog 4 (SPRY4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[355]

Drug(s) Affected By Homeobox protein Hox-D1 (HOXD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[619]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[92]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[303]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]

Drug(s) Affected By Rac GTPase-activating protein 1 (RACGAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[200]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[139]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[295]

Drug(s) Affected By 2-aminomuconic semialdehyde dehydrogenase (ALDH8A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[770]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[332]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Racecadotril	DMFOTZ7	Diarrhea	ME05.1	Approved	[770]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[118]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[749]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[274]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[385]

Drug(s) Affected By Homeobox protein MIXL1 (MIXL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[771]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Dolutegravir	DMCZGRE	Human immunodeficiency virus infection	1C62	Approved	[772]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[355]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[83]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[164]

Drug(s) Affected By Centromere protein H (CENPH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[240]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[773]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]

Drug(s) Affected By Kinetochore-associated protein DSN1 homolog (DSN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[289]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]

Drug(s) Affected By Serine/threonine-protein kinase PLK3 (PLK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[156]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[153]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[113]

Drug(s) Affected By Protein FAM83D (FAM83D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[411]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[295]

Drug(s) Affected By Regulator of cell cycle RGCC (RGCC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[118]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[292]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[167]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[92]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[701]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[113]

Drug(s) Affected By ATP-dependent DNA helicase PIF1 (PIF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[289]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[291]

Drug(s) Affected By Syncoilin (SYNC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[721]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]

Drug(s) Affected By Thiol S-methyltransferase TMT1A (TMT1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[773]

Drug(s) Affected By Cytochrome P450 4F11 (CYP4F11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[774]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[775]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[774]

Drug(s) Affected By Kinetochore protein Spc25 (SPC25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[292]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[591]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]

Drug(s) Affected By DNA polymerase delta subunit 4 (POLD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[283]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[508]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[401]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[355]

Drug(s) Affected By Solute carrier family 40 member 1 (SLC40A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[369]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[438]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[776]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[214]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[222]
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[389]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[145]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]

Drug(s) Affected By Anillin (ANLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[591]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[295]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]

Drug(s) Affected By Unconventional myosin-Vc (MYO5C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[290]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[385]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[777]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[721]

Drug(s) Affected By Lymphoid-specific helicase (HELLS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 19 (TNFRSF19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[214]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[515]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[297]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[515]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[303]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]

Drug(s) Affected By Kinesin-like protein KIF15 (KIF15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[295]

Drug(s) Affected By Sal-like protein 1 (SALL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[165]
Indomethacin	DMSC4A7	Bursitis		Approved	[326]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[385]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[684]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[83]

Drug(s) Affected By FIGNL1-interacting regulator of recombination and mitosis (FIRRM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[83]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[696]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[709]

Drug(s) Affected By 1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 (PNPLA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[447]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[99]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[385]

Drug(s) Affected By Protein diaphanous homolog 3 (DIAPH3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[248]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]

Drug(s) Affected By Structural maintenance of chromosomes protein 4 (SMC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[283]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[201]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[591]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]

Drug(s) Affected By Serine palmitoyltransferase 3 (SPTLC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[385]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[163]

Drug(s) Affected By Transmembrane protein 140 (TMEM140)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[274]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[291]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[92]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]

Drug(s) Affected By Fanconi anemia group I protein (FANCI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[339]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[778]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[295]

Drug(s) Affected By Spermine oxidase (SMOX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[284]
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[283]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[284]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Mestranol	DMG3F94	Contraception	QA21	Approved	[284]

Drug(s) Affected By PCNA-interacting partner (PARPBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[304]

Drug(s) Affected By Membrane progestin receptor gamma (PAQR5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[156]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]

Drug(s) Affected By Protein Mis18-alpha (MIS18A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[380]

Drug(s) Affected By G2 and S phase-expressed protein 1 (GTSE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[186]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[591]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[674]

Drug(s) Affected By Denticleless protein homolog (DTL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[779]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[401]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]

Drug(s) Affected By Kelch-like protein 14 (KLHL14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[292]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[322]

Drug(s) Affected By DNA (DNMT3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[780]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[781]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[782]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[783]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[321]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[341]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[411]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[248]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[716]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[154]

Drug(s) Affected By CAP-Gly domain-containing linker protein 2 (CLIP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[401]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[442]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[646]

Drug(s) Affected By Doublecortin domain-containing protein 2 (DCDC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[291]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[83]

Drug(s) Affected By Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAIAP2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Streptozocin	DMOF7AT	Pancreatic cancer	2C10	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[292]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[644]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[327]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[327]

Drug(s) Affected By SERTA domain-containing protein 1 (SERTAD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[153]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[153]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[153]

Drug(s) Affected By Oxidative stress-induced growth inhibitor 1 (OSGIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[115]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[153]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[153]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[153]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[153]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[153]

Drug(s) Affected By F-box only protein 5 (FBXO5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[354]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[411]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]

Drug(s) Affected By Long-chain-fatty-acid--CoA ligase 5 (ACSL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[99]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[784]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[59]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[273]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[385]

Drug(s) Affected By Protein phosphatase 1H (PPM1H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[303]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[314]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]

Drug(s) Affected By Targeting protein for Xklp2 (TPX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[186]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[295]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]

Drug(s) Affected By Transcription factor MafF (MAFF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[264]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[639]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[99]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[121]

Drug(s) Affected By Sex comb on midleg-like protein 1 (SCML1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[373]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[373]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[646]

Drug(s) Affected By Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (SLC6A14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[92]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[785]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[355]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[54]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[90]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[785]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[165]

Drug(s) Affected By Exonuclease 1 (EXO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[591]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[295]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 3C (PPP1R3C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[198]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[47]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[186]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[118]

Drug(s) Affected By Transcription factor 19 (TCF19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[354]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[292]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[208]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]

Drug(s) Affected By DNA replication complex GINS protein PSF2 (GINS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[191]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[186]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[295]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]

Drug(s) Affected By Dexamethasone-induced Ras-related protein 1 (RASD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[191]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[118]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[150]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[273]

Drug(s) Affected By E3 ubiquitin-protein ligase DTX4 (DTX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[648]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[274]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[385]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[786]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 3 (NFE2L3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[332]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[332]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[308]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]

Drug(s) Affected By Beta/gamma crystallin domain-containing protein 1 (CRYBG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[125]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[787]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[385]

Drug(s) Affected By BTB/POZ domain-containing protein KCTD3 (KCTD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[67]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[97]
Fenretinide	DMRD5SP	Macular degeneration	9B78.3	Phase 3	[514]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[92]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[413]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[413]

Drug(s) Affected By Hairy/enhancer-of-split related with YRPW motif protein 1 (HEY1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[788]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[628]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[113]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]

Drug(s) Affected By Origin recognition complex subunit 6 (ORC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[347]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[98]

Drug(s) Affected By Mitochondrial pyruvate carrier 1 (MPC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[99]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[412]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[412]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[273]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[290]

Drug(s) Affected By Melanoma-associated antigen D1 (MAGED1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[273]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[62]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[393]

Drug(s) Affected By Lymphocyte antigen 96 (LY96)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[214]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[217]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[118]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[292]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]

Drug(s) Affected By Glutathione reductase, mitochondrial (GSR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[789]
Ketoprofen	DMRKXPT	Bursitis		Approved	[46]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[790]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[791]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[116]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[792]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[793]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[794]

Drug(s) Affected By Rap1 GTPase-activating protein 1 (RAP1GAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[118]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[248]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[150]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[703]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[509]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[795]

Drug(s) Affected By Ras-related protein R-Ras2 (RRAS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[117]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[255]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[256]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[248]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[372]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[273]

Drug(s) Affected By Glycerol-3-phosphate acyltransferase 3 (GPAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[153]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[153]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[384]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[146]

Drug(s) Affected By F-box only protein 30 (FBXO30)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[672]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[58]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[153]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[153]

Drug(s) Affected By Transmembrane protease serine 2 (TMPRSS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[796]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[796]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[796]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[796]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[796]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[796]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[796]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[796]

Drug(s) Affected By Serine protease inhibitor Kazal-type 1 (SPINK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[438]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[118]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[62]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[797]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[798]
Fructose	DM43AN2	Vomiting	MD90	Approved	[46]
Ketoprofen	DMRKXPT	Bursitis		Approved	[46]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[799]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[800]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[801]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[802]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[803]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[195]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[214]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[194]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[804]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[205]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[234]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[205]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[196]
Selenium	DM25CGV	N. A.	N. A.	Approved	[180]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[805]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[806]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[807]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[808]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[809]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[810]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[811]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[812]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[813]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[814]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[815]

Drug(s) Affected By Interleukin-4 (IL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[816]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[431]
Tolnaftate	DM28MU7	Dermatophytosis	1F28.2	Approved	[817]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[818]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[819]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[820]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[821]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[318]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[822]

Drug(s) Affected By Insulin-like growth factor 1 receptor (IGF1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[823]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[824]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[446]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[825]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[106]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[826]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[678]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[72]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[72]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[153]

Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[827]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[675]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[828]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[829]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[830]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[831]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[832]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[283]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[833]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[834]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[835]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[836]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[837]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[800]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[838]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[839]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[840]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[841]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[842]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[843]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[844]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[836]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[845]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[846]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[847]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[835]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[46]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[214]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[800]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[838]

Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[848]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[428]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[675]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[828]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[849]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[850]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[851]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[852]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[294]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[853]

Drug(s) Affected By Ras-related C3 botulinum toxin substrate 1 (RAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[583]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[854]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[169]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[854]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[855]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[372]

Drug(s) Affected By Heat shock factor protein 1 (HSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[856]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[857]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[857]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[858]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[859]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[857]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[107]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[857]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[857]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[857]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[566]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[860]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[861]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[862]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[108]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[561]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[863]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[154]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[813]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[864]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[363]
Selenium	DM25CGV	N. A.	N. A.	Approved	[123]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[865]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[389]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[866]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[867]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[349]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[553]

Drug(s) Affected By Protein patched homolog 1 (PTCH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[264]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Vismodegib	DM5IXKQ	Basal cell carcinoma	2C32	Approved	[868]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[869]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[773]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[870]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[290]

Drug(s) Affected By Angiotensin-converting enzyme 2 (ACE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Captopril	DM458UM	Chronic heart failure	BD1Z	Approved	[871]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[796]
Dantrolene	DM1D8XY	Hyperthermia	MG26	Approved	[796]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[796]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[796]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[796]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[796]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[796]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[796]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[796]

Drug(s) Affected By Inosine-5'-monophosphate dehydrogenase 1 (IMPDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[106]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[684]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]

Drug(s) Affected By Glutathione S-transferase A1 (GSTA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[872]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[873]
Thiotepa	DMIZKOP	Breast cancer	2C60-2C65	Approved	[874]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[875]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[876]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[877]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[878]
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[879]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[47]

Drug(s) Affected By HLA class II histocompatibility antigen, DQ alpha 1 chain (HLA-DQA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[880]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[396]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[96]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[73]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[881]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[882]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[883]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[291]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[880]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[884]

Drug(s) Affected By Purine nucleoside phosphorylase (PNP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[150]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[145]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[539]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[125]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]

Drug(s) Affected By HLA class II histocompatibility antigen, DRB1 beta chain (HLA-DRB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[885]
Clindamycin	DM15HL8	Acne vulgaris	ED80	Approved	[885]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[885]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Cefepime	DMHVWIK	Bacterial infection	1A00-1C4Z	Approved	[885]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[85]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[886]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[51]

Drug(s) Affected By Cytosolic 5'-nucleotidase 1A (NT5C1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[61]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[165]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Amidophosphoribosyltransferase (PPAT)	TTZFTY4	PUR1_HUMAN	Inhibitor	[3]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[4]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Substrate	[5]
Glutathione S-transferase mu-1 (GSTM1)	DEYZEJA	GSTM1_HUMAN	Substrate	[6]
Thiopurine methyltransferase (TPMT)	DEFQ8VO	TPMT_HUMAN	Substrate	[7]
Glutathione S-transferase alpha-2 (GSTA2)	DEH49YS	GSTA2_HUMAN	Substrate	[6]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
(Lyso)-N-acylphosphatidylethanolamine lipase (ABHD4)	OTQK3M9X	ABHD4_HUMAN	Gene/Protein Processing	[8]
1-acylglycerol-3-phosphate O-acyltransferase PNPLA3 (PNPLA3)	OTR4990X	PLPL3_HUMAN	Gene/Protein Processing	[8]
11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1)	OTO7FJA9	DHI1_HUMAN	Gene/Protein Processing	[9]
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)	OTHF4H9U	DHI2_HUMAN	Gene/Protein Processing	[8]
14-3-3 protein sigma (SFN)	OTLJCZ1U	1433S_HUMAN	Gene/Protein Processing	[8]
2'-5'-oligoadenylate synthase 1 (OAS1)	OT8ZLOCY	OAS1_HUMAN	Gene/Protein Processing	[9]
2'-5'-oligoadenylate synthase 3 (OAS3)	OT6E5FYS	OAS3_HUMAN	Gene/Protein Processing	[9]
2-aminomuconic semialdehyde dehydrogenase (ALDH8A1)	OTINY3MW	AL8A1_HUMAN	Gene/Protein Processing	[8]
2-iminobutanoate/2-iminopropanoate deaminase (RIDA)	OTW4098I	RIDA_HUMAN	Gene/Protein Processing	[8]
2-phosphoxylose phosphatase 1 (PXYLP1)	OTX8T7F6	PXYP1_HUMAN	Gene/Protein Processing	[8]

References

• [1] Azathioprine FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7120).
• [3] IMPDH activity in thiopurine-treated patients with inflammatory bowel disease - relation to TPMT activity and metabolite concentrations. Br J Clin Pharmacol. 2008 Jan;65(1):69-77.
• [4] Caco-2 permeability, P-glycoprotein transport ratios and brain penetration of heterocyclic drugs. Int J Pharm. 2003 Sep 16;263(1-2):113-22.
• [5] Brassica vegetables increase and apiaceous vegetables decrease cytochrome P450 1A2 activity in humans: changes in caffeine metabolite ratios in response to controlled vegetable diets. Carcinogenesis. 2000 Jun;21(6):1157-62.
• [6] PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA2040)
• [7] Nodular regenerative liver hyperplasia as a complication of azathioprine-containing immunosuppressive treatment for Crohn's disease. Immunopharmacol Immunotoxicol. 2011 Jun;33(2):398-402.
• [8] A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo. Carcinogenesis. 2012 Jul;33(7):1421-9.
• [9] Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
• [10] 6-mercaptopurine (6-MP) induces p53-mediated apoptosis of neural progenitor cells in the developing fetal rodent brain. Neurotoxicol Teratol. 2009 Jul-Aug;31(4):198-202.
• [11] Structure-activity relationships for inhibition of inosine monophosphate dehydrogenase and differentiation induction of K562 cells among the mycoph... Bioorg Med Chem. 2010 Nov 15;18(22):8106-11.
• [12] Dual inhibitors of inosine monophosphate dehydrogenase and histone deacetylases for cancer treatment. J Med Chem. 2007 Dec 27;50(26):6685-91.
• [13] Bis(sulfonamide) isosters of mycophenolic adenine dinucleotide analogues: inhibition of inosine monophosphate dehydrogenase. Bioorg Med Chem. 2008 Aug 1;16(15):7462-9.
• [14] How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
• [15] Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
• [16] MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents. Cancer Chemother Pharmacol. 2009 Jun;64(1):183-8.
• [17] Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
• [18] Folate transporter expression decreases in the human placenta throughout pregnancy and in pre-eclampsia. Pregnancy Hypertens. 2012 Apr;2(2):123-31.
• [19] Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8.
• [20] Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92.
• [21] Association of genetic polymorphisms in the influx transporter SLCO1B3 and the efflux transporter ABCB1 with imatinib pharmacokinetics in patients with chronic myeloid leukemia. Ther Drug Monit. 2011 Apr;33(2):244-50.
• [22] Roles of cytochromes P450 1A2, 2A6, and 2C8 in 5-fluorouracil formation from tegafur, an anticancer prodrug, in human liver microsomes. Drug Metab Dispos. 2000 Dec;28(12):1457-63.
• [23] Effects of polyunsaturated fatty acids on prostaglandin synthesis and cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines in human adenocarcinoma colon cells. Mol Carcinog. 2004 Jul;40(3):180-8.
• [24] Endoxifen and other metabolites of tamoxifen inhibit human hydroxysteroid sulfotransferase 2A1 (hSULT2A1). Drug Metab Dispos. 2014 Nov;42(11):1843-50.
• [25] Cytochrome P450 1A2 (CYP1A2) activity and risk factors for breast cancer: a cross-sectional study. Breast Cancer Res. 2004;6(4):R352-65.
• [26] PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses. Pharmacogenet Genomics. 2015 Aug;25(8):416-26.
• [27] The effect of apigenin on pharmacokinetics of imatinib and its metabolite N-desmethyl imatinib in rats. Biomed Res Int. 2013;2013:789184.
• [28] Effects of morin on the pharmacokinetics of etoposide in rats. Biopharm Drug Dispos. 2007 Apr;28(3):151-6.
• [29] The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers. Sci Total Environ. 2007 Aug 1;381(1-3):38-46.
• [30] Identification of P450 enzymes involved in metabolism of verapamil in humans. Naunyn Schmiedebergs Arch Pharmacol. 1993 Sep;348(3):332-7.
• [31] Metabolism and metabolic inhibition of xanthotoxol in human liver microsomes. Evid Based Complement Alternat Med. 2016;2016:5416509.
• [32] Genetics of rheumatoid arthritis. Mayo Clin Proc. 2006 Jan;81(1):94-101.
• [33] Polymorphism of estrogen metabolism genes and cataract. Med Hypotheses. 2004;63(3):494-7.
• [34] Influence of estradiol-17 beta and progesterone on catechol-O-methyltransferase and monoamine oxidase activities in uterine artery and myometrium of ovariectomized pigs. Arch Vet Pol. 1993;33(1-2):29-37.
• [35] The degree of myelosuppression during maintenance therapy of adolescents with B-lineage intermediate risk acute lymphoblastic leukemia predicts risk of relapse. Leukemia. 2010 Apr;24(4):715-20.
• [36] Histamine-N-methyl transferase polymorphism and risk for multiple sclerosis. Eur J Neurol. 2010 Feb;17(2):335-8.
• [37] Ascorbic acid inhibits spinal meningeal catechol-o-methyl transferase in vitro, markedly increasing epinephrine bioavailability. Anesthesiology. 1997 Feb;86(2):405-9.
• [38] Cefazolin administration and 2-methyl-1,3,4-thiadiazole-5-thiol in human tissue: possible relationship to hypoprothrombinemia. Drug Metab Dispos. 2002 Oct;30(10):1123-8.
• [39] Adrenal catecholamines and their metabolism in the vitamin A deficient rat. Ann Nutr Metab. 1983;27(3):220-7.
• [40] Reduced 3-O-methyl-dopa levels in OCD patients and their unaffected parents is associated with the low activity M158 COMT allele. Am J Med Genet B Neuropsychiatr Genet. 2010 Mar 5;153B(2):542-548.
• [41] Usefulness of thiopurine methyltransferase and thiopurine metabolite analysis in clinical practice in patients with inflammatory bowel diseases. Acta Gastroenterol Belg. 2010 Jul-Sep;73(3):331-5.
• [42] Endothelial cells do not express GSTA1: potential relevance to busulfan-mediated endothelial damage during haematopoietic stem cell transplantation. Eur J Haematol. 2008 Apr;80(4):299-302.
• [43] Glutathione S-transferase genetic polymorphisms and individual sensitivity to the ototoxic effect of cisplatin. Anticancer Drugs. 2000 Sep;11(8):639-43.
• [44] PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA150642262)
• [45] Busulfan conjugation by glutathione S-transferases alpha, mu, and pi. Drug Metab Dispos. 1996 Sep;24(9):1015-9.
• [46] ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
• [47] Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
• [48] Human drug metabolism genes in parathion-and estrogen-treated breast cells. Int J Mol Med. 2007 Dec;20(6):875-81.
• [49] Low-dose azathioprine is effective and safe for maintenance of remission in patients with ulcerative colitis. J Gastroenterol. 2003;38(8):740-6. doi: 10.1007/s00535-003-1139-2.
• [50] Clinical Pharmacogenetics Implementation Consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing. Clin Pharmacol Ther. 2011 Mar;89(3):387-91. doi: 10.1038/clpt.2010.320. Epub 2011 Jan 26.
• [51] Clinical determinants of response to irinotecan-based therapy derived from cell line models. Clin Cancer Res. 2008 Oct 15;14(20):6647-55.
• [52] Genetic polymorphisms of drug-metabolising enzymes and drug transporters in the chemotherapeutic treatment of cancer. Clin Pharmacokinet. 2006;45(3):253-85. doi: 10.2165/00003088-200645030-00003.
• [53] Inhibition of human thiopurine methyltransferase by furosemide, bendroflumethiazide and trichlormethiazide. Eur J Clin Pharmacol. 1996;49(5):393-6.
• [54] Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
• [55] Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
• [56] Overexpression of GSTA2 protects against cell cycle arrest and apoptosis induced by the DNA inter-strand crosslinking nitrogen mustard, mechlorethamine. J Cell Biochem. 2005 May 15;95(2):339-51. doi: 10.1002/jcb.20440.
• [57] The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
• [58] Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
• [59] Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes. Toxicol Lett. 2018 Jun 1;289:1-13.
• [60] Capturing time-dependent activation of genes and stress-response pathways using transcriptomics in iPSC-derived renal proximal tubule cells. Cell Biol Toxicol. 2023 Aug;39(4):1773-1793. doi: 10.1007/s10565-022-09783-5. Epub 2022 Dec 31.
• [61] Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
• [62] Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
• [63] Dose- and time-dependent effects of phenobarbital on gene expression profiling in human hepatoma HepaRG cells. Toxicol Appl Pharmacol. 2009 Feb 1;234(3):345-60.
• [64] Cytochrome P450-mediated bioactivation of mefenamic acid to quinoneimine intermediates and inactivation by human glutathione S-transferases. Chem Res Toxicol. 2014 Dec 15;27(12):2071-81.
• [65] Stereoselective conjugation of prostaglandin A2 and prostaglandin J2 with glutathione, catalyzed by the human glutathione S-transferases A1-1, A2-2, M1a-1a, and P1-1. Chem Res Toxicol. 1997 Mar;10(3):310-7. doi: 10.1021/tx9601770.
• [66] Influence of glutathione S-transferase A1, P1, M1, T1 polymorphisms on oral busulfan pharmacokinetics in children with congenital hemoglobinopathies undergoing hematopoietic stem cell transplantation. Pediatr Blood Cancer. 2010 Dec 1;55(6):1172-9. doi: 10.1002/pbc.22739.
• [67] Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
• [68] Association of polymorphism in alcohol dehydrogenase and interaction with other genetic risk factors with alcoholic liver cirrhosis. Drug Alcohol Depend. 2010 Jun 1;109(1-3):190-7. doi: 10.1016/j.drugalcdep.2010.01.010. Epub 2010 Feb 18.
• [69] Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
• [70] Inhibition of human glutathione S-transferases by dopamine, alpha-methyldopa and their 5-S-glutathionyl conjugates. Chem Biol Interact. 1994 Jan;90(1):87-99.
• [71] Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
• [72] Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
• [73] Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
• [74] Characteristics of P388/VMDRC.04, a simple, sensitive model for studying P-glycoprotein antagonists. Cancer Res. 1994 Feb 1;54(3):730-7.
• [75] Michaelis-Menten kinetic analysis of drugs of abuse to estimate their affinity to human P-glycoprotein. Toxicol Lett. 2013 Feb 27;217(2):137-42. doi: 10.1016/j.toxlet.2012.12.012. Epub 2012 Dec 27.
• [76] Editor's Highlight: PlacentalDisposition and Effects of Crizotinib: An Ex Vivo Study in the Isolated Dual-Side Perfused Human Cotyledon. Toxicol Sci. 2017 Jun 1;157(2):500-509. doi: 10.1093/toxsci/kfx063.
• [77] Functional evaluation of polymorphisms in the human ABCB1 gene and the impact on clinical responses of antiepileptic drugs. Pharmacogenet Genomics. 2008 May;18(5):390-402. doi: 10.1097/FPC.0b013e3282f85e36.
• [78] Cepharanthine potently enhances the sensitivity of anticancer agents in K562 cells. Cancer Sci. 2005 Jun;96(6):372-6. doi: 10.1111/j.1349-7006.2005.00057.x.
• [79] Clinical pharmacokinetic monitoring of itraconazole is warranted in only a subset of patients. Ther Drug Monit. 2005 Jun;27(3):322-33. doi: 10.1097/01.ftd.0000150135.22645.ea.
• [80] Evaluation of antipsychotic drugs as inhibitors of multidrug resistance transporter P-glycoprotein. Psychopharmacology (Berl). 2006 Sep;187(4):415-23. doi: 10.1007/s00213-006-0437-9. Epub 2006 Jun 30.
• [81] Actions of the selective protein kinase C inhibitor PKC412 on B-chronic lymphocytic leukemia cells in vitro. Haematologica. 2002 Feb;87(2):167-76.
• [82] Characterization of the ATPase activity of the Mr 170,000 to 180,000 membrane glycoprotein (P-glycoprotein) associated with multidrug resistance in K562/ADM cells. Cancer Res. 1988 Sep 1;48(17):4926-32.
• [83] Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
• [84] Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
• [85] Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
• [86] Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
• [87] Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
• [88] ITPA polymorphism affects ribavirin-induced anemia and outcomes of therapy--a genome-wide study of Japanese HCV virus patients. Gastroenterology. 2010 Oct;139(4):1190-7. doi: 10.1053/j.gastro.2010.06.071. Epub 2010 Jul 14.
• [89] Relationship between genetic variants in the adenosine pathway and outcome of methotrexate treatment in patients with recent-onset rheumatoid arthritis. Arthritis Rheum. 2006 Sep;54(9):2830-9. doi: 10.1002/art.22032.
• [90] Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
• [91] Design and synthesis of pyrimidinone and pyrimidinedione inhibitors of dipeptidyl peptidase IV. J Med Chem. 2011 Jan 27;54(2):510-24.
• [92] Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
• [93] Grouping of histone deacetylase inhibitors and other toxicants disturbing neural crest migration by transcriptional profiling. Neurotoxicology. 2015 Sep;50:56-70.
• [94] The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
• [95] Novel hydrazine derivatives as selective DPP-IV inhibitors: findings from virtual screening and validation through molecular dynamics simulations. J Mol Model. 2014 Apr;20(4):2118. doi: 10.1007/s00894-014-2118-7. Epub 2014 Apr 1.
• [96] Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
• [97] LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
• [98] Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.
• [99] Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
• [100] Rifampin Regulation of Drug Transporters Gene Expression and the Association of MicroRNAs in Human Hepatocytes. Front Pharmacol. 2016 Apr 26;7:111.
• [101] In vitro and pharmacophore-based discovery of novel hPEPT1 inhibitors. Pharm Res. 2005 Apr;22(4):512-7. doi: 10.1007/s11095-005-2505-y. Epub 2005 Apr 7.
• [102] Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
• [103] Enhancement effect of resveratrol on the intestinal absorption of bestatin by regulating PEPT1, MDR1 and MRP2 in vivo and in vitro. Int J Pharm. 2015 Nov 10;495(1):588-598. doi: 10.1016/j.ijpharm.2015.09.042. Epub 2015 Sep 21.
• [104] Affinity and translocation relationships via hPEPT1 of H-X aa-Ser-OH dipeptides: evaluation of H-Phe-Ser-OH as a pro-moiety for ibuprofen and benzoic acid prodrugs. Eur J Pharm Biopharm. 2011 Feb;77(2):327-31. doi: 10.1016/j.ejpb.2010.12.009. Epub 2010 Dec 13.
• [105] Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
• [106] Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy. Med Oncol. 2011 Dec;28(4):1395-404. doi: 10.1007/s12032-010-9603-3. Epub 2010 Jul 2.
• [107] Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
• [108] Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Toxicol Appl Pharmacol. 2012 Jun 1;261(2):204-16.
• [109] THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
• [110] Petit E, Langouet S, Akhdar H, Nicolas-Nicolaz C, Guillouzo A, Morel F. Differential toxic effects of azathioprine, 6-mercaptopurine and 6-thioguanine on human hepatocytes. Toxicol In Vitro. 2008;22(3):632-642. [PMID: 18222062]
• [111] Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
• [112] Gene expression profiling of early primary biliary cirrhosis: possible insights into the mechanism of action of ursodeoxycholic acid. Liver Int. 2008 Aug;28(7):997-1010. doi: 10.1111/j.1478-3231.2008.01744.x. Epub 2008 Apr 15.
• [113] CXCL14 downregulation in human keratinocytes is a potential biomarker for a novel in vitro skin sensitization test. Toxicol Appl Pharmacol. 2020 Jan 1;386:114828. doi: 10.1016/j.taap.2019.114828. Epub 2019 Nov 14.
• [114] Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Redox Biol. 2020 Jan;28:101321. doi: 10.1016/j.redox.2019.101321. Epub 2019 Sep 5.
• [115] Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
• [116] Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways. Food Chem Toxicol. 2021 Dec;158:112664. doi: 10.1016/j.fct.2021.112664. Epub 2021 Nov 9.
• [117] Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
• [118] Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
• [119] Retinoic acid induces Gpx2 gene expression in MCF-7 human breast cancer cells. J Nutr. 1999 Oct;129(10):1846-54. doi: 10.1093/jn/129.10.1846.
• [120] Expression of gastrointestinal glutathione peroxidase is inversely correlated to the presence of hepatitis C virus subgenomic RNA in human liver cells. J Biol Chem. 2005 Mar 11;280(10):8831-41. doi: 10.1074/jbc.M413730200. Epub 2004 Dec 28.
• [121] Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury. Arch Toxicol. 2020 Apr;94(4):1151-1172. doi: 10.1007/s00204-020-02691-9. Epub 2020 Mar 10.
• [122] Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
• [123] Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
• [124] Keratinocyte gene expression profiles discriminate sensitizing and irritating compounds. Toxicol Sci. 2010 Sep;117(1):81-9.
• [125] The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
• [126] Plasma glutathione peroxidase and its relationship to renal proximal tubule function. Mol Genet Metab. 1998 Nov;65(3):238-45. doi: 10.1006/mgme.1998.2760.
• [127] Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun. 2008 Dec 19;377(3):797-802.
• [128] Essential role of Nrf2 in keratinocyte protection from UVA by quercetin. Biochem Biophys Res Commun. 2009 Sep 11;387(1):109-14. doi: 10.1016/j.bbrc.2009.06.136. Epub 2009 Jul 1.
• [129] Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
• [130] Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq. Arch Toxicol. 2018 Aug;92(8):2517-2531.
• [131] Changes in gene expression profiles of multiple myeloma cells induced by arsenic trioxide (ATO): possible mechanisms to explain ATO resistance in vivo. Br J Haematol. 2005 Mar;128(5):636-44.
• [132] An in vitro skin sensitization assay termed EpiSensA for broad sets of chemicals including lipophilic chemicals and pre/pro-haptens. Toxicol In Vitro. 2017 Apr;40:11-25. doi: 10.1016/j.tiv.2016.12.005. Epub 2016 Dec 10.
• [133] Chromium III histidinate exposure modulates gene expression in HaCaT human keratinocytes exposed to oxidative stress. Biol Trace Elem Res. 2010 Oct;137(1):23-39.
• [134] Essential role of Nrf2 in protection against hydroquinone- and benzoquinone-induced cytotoxicity. Toxicol In Vitro. 2011 Mar;25(2):521-9.
• [135] Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
• [136] Ursodeoxycholic acid induces glutathione synthesis through activation of PI3K/Akt pathway in HepG2 cells. Biochem Pharmacol. 2009 Mar 1;77(5):858-66. doi: 10.1016/j.bcp.2008.11.012. Epub 2008 Nov 25.
• [137] Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
• [138] Interplay between cellular methyl metabolism and adaptive efflux during oncogenic transformation from chronic arsenic exposure in human cells. J Biol Chem. 2008 Jul 11;283(28):19342-50.
• [139] Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer Sci. 2007 Jun;98(6):890-9.
• [140] Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
• [141] Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
• [142] Survival of retinal pigment epithelium after exposure to prolonged oxidative injury: a detailed gene expression and cellular analysis. Invest Ophthalmol Vis Sci. 2004 Oct;45(10):3767-77.
• [143] Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
• [144] Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
• [145] Global effects of inorganic arsenic on gene expression profile in human macrophages. Mol Immunol. 2009 Feb;46(4):649-56.
• [146] From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
• [147] Targeted removal of PML-RARalpha protein is required prior to inhibition of histone deacetylase for overcoming all-trans retinoic acid differentiation resistance in acute promyelocytic leukemia. Blood. 2002 Aug 1;100(3):1008-13. doi: 10.1182/blood.v100.3.1008.
• [148] Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
• [149] White-to-brown metabolic conversion of human adipocytes by JAK inhibition. Nat Cell Biol. 2015 Jan;17(1):57-67. doi: 10.1038/ncb3075. Epub 2014 Dec 8.
• [150] A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
• [151] Classification of heavy-metal toxicity by human DNA microarray analysis. Environ Sci Technol. 2007 May 15;41(10):3769-74.
• [152] Anti-oncogenic and pro-differentiation effects of clorgyline, a monoamine oxidase A inhibitor, on high grade prostate cancer cells. BMC Med Genomics. 2009 Aug 20;2:55. doi: 10.1186/1755-8794-2-55.
• [153] Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
• [154] Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
• [155] Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner. Carcinogenesis. 2009 Aug;30(8):1320-9. doi: 10.1093/carcin/bgp138. Epub 2009 Jun 5.
• [156] DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
• [157] Dihydroartemisinin mediating PKM2-caspase-8/3-GSDME axis for pyroptosis in esophageal squamous cell carcinoma. Chem Biol Interact. 2021 Dec 1;350:109704. doi: 10.1016/j.cbi.2021.109704. Epub 2021 Oct 13.
• [158] Differential effects of statins on relevant functions of human monocyte-derived dendritic cells. J Leukoc Biol. 2006 Mar;79(3):529-38. doi: 10.1189/jlb.0205064. Epub 2005 Dec 30.
• [159] Quercetin regulates oxidized LDL induced inflammatory changes in human PBMCs by modulating the TLR-NF-B signaling pathway. Immunobiology. 2011 Mar;216(3):367-73. doi: 10.1016/j.imbio.2010.07.011. Epub 2010 Aug 19.
• [160] Synergistic antiproliferative effect of arsenic trioxide combined with bortezomib in HL60 cell line and primary blasts from patients affected by myeloproliferative disorders. Cancer Genet Cytogenet. 2010 Jun;199(2):110-20. doi: 10.1016/j.cancergencyto.2010.02.010.
• [161] A microarray study on the effect of four hormone therapy regimens on gene transcription in whole blood from healthy postmenopausal women. Thromb Res. 2012 Jul;130(1):45-51. doi: 10.1016/j.thromres.2011.12.009. Epub 2012 Jan 2.
• [162] Mechanical stress-activated immune response genes via Sirtuin 1 expression in human periodontal ligament cells. Clin Exp Immunol. 2012 Apr;168(1):113-24. doi: 10.1111/j.1365-2249.2011.04549.x.
• [163] Characterizing the genetic basis for nicotine induced cancer development: a transcriptome sequencing study. PLoS One. 2013 Jun 18;8(6):e67252.
• [164] Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
• [165] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
• [166] Benzodithiophenes potentiate differentiation of acute promyelocytic leukemia cells by lowering the threshold for ligand-mediated corepressor/coactivator exchange with retinoic acid receptor alpha and enhancing changes in all-trans-retinoic acid-regulated gene expression. Cancer Res. 2005 Sep 1;65(17):7856-65. doi: 10.1158/0008-5472.CAN-05-1056.
• [167] Cyclosporine A--induced oxidative stress in human renal mesangial cells: a role for ERK 1/2 MAPK signaling. Toxicol Sci. 2012 Mar;126(1):101-13.
• [168] Retinoic acid-induced downmodulation of telomerase activity in human cancer cells. Exp Mol Pathol. 2005 Oct;79(2):108-17.
• [169] DNA array analysis of the effects of aspirin on colon cancer cells: involvement of Rac1. Carcinogenesis. 2004 Jul;25(7):1293-8.
• [170] Investigation of in vitro odonto/osteogenic capacity of cannabidiol on human dental pulp cell. J Dent. 2021 Jun;109:103673. doi: 10.1016/j.jdent.2021.103673. Epub 2021 Apr 16.
• [171] Patterns of some extracellular matrix gene expression are similar in cells from cleft lip-palate patients and in human palatal fibroblasts exposed to diazepam in culture. Toxicology. 2009 Mar 4;257(1-2):10-6. doi: 10.1016/j.tox.2008.12.002. Epub 2008 Dec 9.
• [172] Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
• [173] Protective effects of myricitrin against osteoporosis via reducing reactive oxygen species and bone-resorbing cytokines. Toxicol Appl Pharmacol. 2014 Nov 1;280(3):550-60.
• [174] Gene expression profiling of rheumatoid arthritis synovial cells treated with antirheumatic drugs. J Biomol Screen. 2007 Apr;12(3):328-40. doi: 10.1177/1087057107299261. Epub 2007 Mar 22.
• [175] Acinar cell-specific knockout of the PTHrP gene decreases the proinflammatory and profibrotic responses in pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2014 Sep 1;307(5):G533-49. doi: 10.1152/ajpgi.00428.2013. Epub 2014 Jul 17.
• [176] The effects of particulate wear debris, cytokines, and growth factors on the functions of MG-63 osteoblasts. J Bone Joint Surg Am. 2001 Feb;83(2):201-11. doi: 10.2106/00004623-200102000-00007.
• [177] Inhibition of systemic sclerosis dermal fibroblast type I collagen production and gene expression by simvastatin. Arthritis Rheum. 2006 Apr;54(4):1298-308. doi: 10.1002/art.21723.
• [178] Antifibrotic effects of quercetin in primary orbital fibroblasts and orbital fat tissue cultures of Graves' orbitopathy. Invest Ophthalmol Vis Sci. 2012 Aug 31;53(9):5921-9. doi: 10.1167/iovs.12-9646.
• [179] Neuroprotective effects of glucomoringin-isothiocyanate against H(2)O(2)-Induced cytotoxicity in neuroblastoma (SH-SY5Y) cells. Neurotoxicology. 2019 Dec;75:89-104. doi: 10.1016/j.neuro.2019.09.008. Epub 2019 Sep 12.
• [180] Changes in gene expression profiles in response to selenium supplementation among individuals with arsenic-induced pre-malignant skin lesions. Toxicol Lett. 2007 Mar 8;169(2):162-76. doi: 10.1016/j.toxlet.2007.01.006. Epub 2007 Jan 19.
• [181] P450 3A-catalyzed O-dealkylation of lapatinib induces mitochondrial stress and activates Nrf2. Chem Res Toxicol. 2016 May 16;29(5):784-96.
• [182] Epinephrine upregulates superoxide dismutase in human coronary artery endothelial cells. Free Radic Biol Med. 2001 Jan 15;30(2):148-53.
• [183] Cissus quadrangularis ethanol extract upregulates superoxide dismutase, glutathione peroxidase and endothelial nitric oxide synthase expression in hydrogen peroxide-injured human ECV304 cells. J Ethnopharmacol. 2012 Sep 28;143(2):664-72.
• [184] Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
• [185] Manganese superoxide dismutase is a promising target for enhancing chemosensitivity of basal-like breast carcinoma. Antioxid Redox Signal. 2014 May 20;20(15):2326-46. doi: 10.1089/ars.2013.5295. Epub 2013 Nov 14.
• [186] Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4050-61.
• [187] Pharmacogenomic analysis of acute promyelocytic leukemia cells highlights CYP26 cytochrome metabolism in differential all-trans retinoic acid sensitivity. Blood. 2007 May 15;109(10):4450-60.
• [188] Genomic profiling uncovers a molecular pattern for toxicological characterization of mutagens and promutagens in vitro. Toxicol Sci. 2011 Jul;122(1):185-97.
• [189] Proteomic and functional analyses reveal a dual molecular mechanism underlying arsenic-induced apoptosis in human multiple myeloma cells. J Proteome Res. 2009 Jun;8(6):3006-19.
• [190] Mechanisms of dexamethasone-induced disturbed sleep and fatigue in paediatric patients receiving treatment for ALL. Eur J Cancer. 2010 Jul;46(10):1848-55. doi: 10.1016/j.ejca.2010.03.026. Epub 2010 Apr 17.
• [191] Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
• [192] Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x. Epub 2009 Apr 8.
• [193] Some HIV antiretrovirals increase oxidative stress and alter chemokine, cytokine or adiponectin production in human adipocytes and macrophages. Antivir Ther. 2007;12(4):489-500.
• [194] ERE-independent ERalpha target genes differentially expressed in human breast tumors. Mol Cell Endocrinol. 2005 Dec 21;245(1-2):53-9. doi: 10.1016/j.mce.2005.10.003. Epub 2005 Nov 17.
• [195] Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts. Biomed Res Int. 2015;2015:257090. doi: 10.1155/2015/257090. Epub 2015 Aug 3.
• [196] (9)-Tetrahydrocannabinol Suppresses Monocyte-Mediated Astrocyte Production of Monocyte Chemoattractant Protein 1 and Interleukin-6 in a Toll-Like Receptor 7-Stimulated Human Coculture. J Pharmacol Exp Ther. 2019 Oct;371(1):191-201. doi: 10.1124/jpet.119.260661. Epub 2019 Aug 5.
• [197] Blood cell oxidative stress precedes hemolysis in whole blood-liver slice co-cultures of rat, dog, and human tissues. Toxicol Appl Pharmacol. 2010 May 1;244(3):354-65. doi: 10.1016/j.taap.2010.01.017. Epub 2010 Feb 6.
• [198] Inhibiting Heat Shock Proteins Can Potentiate the Cytotoxic Effect of Cannabidiol in Human Glioma Cells. Anticancer Res. 2015 Nov;35(11):5827-37.
• [199] A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system. Toxicol Sci. 2005 Feb;83(2):282-92.
• [200] Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells. J Cell Biochem. 2006 Aug 1;98(5):1163-84.
• [201] Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
• [202] Determination of phospholipidosis potential based on gene expression analysis in HepG2 cells. Toxicol Sci. 2007 Mar;96(1):101-14.
• [203] ROS-dependent DNA damage contributes to crizotinib-induced hepatotoxicity via the apoptotic pathway. Toxicol Appl Pharmacol. 2019 Nov 15;383:114768. doi: 10.1016/j.taap.2019.114768. Epub 2019 Oct 19.
• [204] Antitumor action of the MET tyrosine kinase inhibitor crizotinib (PF-02341066) in gastric cancer positive for MET amplification. Mol Cancer Ther. 2012 Jul;11(7):1557-64. doi: 10.1158/1535-7163.MCT-11-0934. Epub 2012 Jun 22.
• [205] An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
• [206] All-trans retinoic acid inhibits the cell proliferation but enhances the cell invasion through up-regulation of c-met in pancreatic cancer cells. Cancer Lett. 2005 Jun 28;224(2):303-10. doi: 10.1016/j.canlet.2004.10.016. Epub 2004 Dec 8.
• [207] Retinoid-mediated stimulation of steroid sulfatase activity in myeloid leukemic cell lines requires RARalpha and RXR and involves the phosphoinositide 3-kinase and ERK-MAP kinase pathways. J Cell Biochem. 2006 Feb 1;97(2):327-50. doi: 10.1002/jcb.20579.
• [208] Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
• [209] Synthesis and steroid sulphatase inhibitory activity of C19- and C21-steroidal derivatives bearing a benzyl-inhibiting group. Eur J Med Chem. 2001 Jul-Aug;36(7-8):659-71. doi: 10.1016/s0223-5234(01)01262-4.
• [210] Stilbene-based inhibitors of estrone sulfatase with a dual mode of action in human breast cancer cells. Arch Pharm (Weinheim). 2004 Dec;337(12):634-44. doi: 10.1002/ardp.200400904.
• [211] Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
• [212] Folic acid induces cell type-specific changes in the transcriptome of breast cancer cell lines: a proof-of-concept study. J Nutr Sci. 2016 Apr 26;5:e17. doi: 10.1017/jns.2016.8. eCollection 2016.
• [213] Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
• [214] Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
• [215] Analysis of estrogen agonism and antagonism of tamoxifen, raloxifene, and ICI182780 in endometrial cancer cells: a putative role for the epidermal growth factor receptor ligand amphiregulin. J Soc Gynecol Investig. 2005 Oct;12(7):e55-67.
• [216] Identification of genes linked to gefitinib treatment in prostate cancer cell lines with or without resistance to androgen: a clue to application of gefitinib to hormone-resistant prostate cancer. Oncol Rep. 2006 Jun;15(6):1453-60.
• [217] MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia. Cell Biol Toxicol. 2023 Feb;39(1):201-216. doi: 10.1007/s10565-021-09639-4. Epub 2021 Sep 28.
• [218] Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7653-8.
• [219] Monitoring of deiodinase deficiency based on transcriptomic responses in SH-SY5Y cells. Arch Toxicol. 2013 Jun;87(6):1103-13. doi: 10.1007/s00204-013-1018-4. Epub 2013 Feb 10.
• [220] Evaluation of early biomarkers of muscle anabolic response to testosterone. J Cachexia Sarcopenia Muscle. 2011 Mar;2(1):45-56. doi: 10.1007/s13539-011-0021-y. Epub 2011 Feb 26.
• [221] Expression profiling in squamous carcinoma cells reveals pleiotropic effects of vitamin D3 analog EB1089 signaling on cell proliferation, differentiation, and immune system regulation. Mol Endocrinol. 2002 Jun;16(6):1243-56.
• [222] Unique signatures of stress-induced senescent human astrocytes. Exp Neurol. 2020 Dec;334:113466. doi: 10.1016/j.expneurol.2020.113466. Epub 2020 Sep 17.
• [223] Adipogenic Effects and Gene Expression Profiling of Firemaster? 550 Components in Human Primary Preadipocytes. Environ Health Perspect. 2017 Sep 14;125(9):097013. doi: 10.1289/EHP1318.
• [224] Direct and indirect effects of retinoic acid on human Th2 cytokine and chemokine expression by human T lymphocytes. BMC Immunol. 2006 Nov 21;7:27. doi: 10.1186/1471-2172-7-27.
• [225] Combination of thalidomide and cisplatin in an head and neck squamous cell carcinomas model results in an enhanced antiangiogenic activity in vitro and in vivo. Int J Cancer. 2007 Oct 15;121(8):1697-704. doi: 10.1002/ijc.22867.
• [226] Alcohol and Cannabinoids Differentially Affect HIV Infection and Function of Human Monocyte-Derived Dendritic Cells (MDDC). Front Microbiol. 2015 Dec 22;6:1452. doi: 10.3389/fmicb.2015.01452. eCollection 2015.
• [227] Glucocorticoids inhibit cell death in ovarian cancer and up-regulate caspase inhibitor cIAP2. Clin Cancer Res. 2005 Sep 1;11(17):6325-32. doi: 10.1158/1078-0432.CCR-05-0182.
• [228] Metronomic gemcitabine suppresses tumour growth, improves perfusion, and reduces hypoxia in human pancreatic ductal adenocarcinoma. Br J Cancer. 2010 Jun 29;103(1):52-60.
• [229] Immunomodulatory derivative of thalidomide (IMiD CC-4047) induces a shift in lineage commitment by suppressing erythropoiesis and promoting myelopoiesis. Blood. 2005 May 15;105(10):3833-40. doi: 10.1182/blood-2004-03-0828. Epub 2004 Aug 3.
• [230] Monomeric and oligomeric flavanols maintain the endogenous glucocorticoid response in human macrophages in pro-oxidant conditions in vitro. Chem Biol Interact. 2018 Aug 1;291:237-244.
• [231] Nicotine up-regulates IL-8 expression in human gingival epithelial cells following stimulation with IL-1 or P. gingivalis lipopolysaccharide via nicotinic acetylcholine receptor signalling. Arch Oral Biol. 2012 May;57(5):483-90. doi: 10.1016/j.archoralbio.2011.10.007. Epub 2011 Nov 25.
• [232] Ca(2+) Signaling and IL-8 Secretion in Human Testicular Peritubular Cells Involve the Cation Channel TRPV2. Int J Mol Sci. 2018 Sep 19;19(9):2829. doi: 10.3390/ijms19092829.
• [233] Nitrogen mustard prevents transport of Fra-1 into the nucleus to promote c-Fos- and FosB-dependent IL-8 induction in injured mouse epidermis. Toxicol Lett. 2020 Feb 1;319:256-263. doi: 10.1016/j.toxlet.2019.10.006. Epub 2019 Oct 19.
• [234] Gypenosides protect retinal pigment epithelium cells from oxidative stress. Food Chem Toxicol. 2018 Feb;112:76-85.
• [235] Nitric oxide synthase inhibitors attenuate ozone-induced airway inflammation in guinea pigs. Possible role of interleukin-8. Am J Respir Crit Care Med. 2000 Jan;161(1):249-56. doi: 10.1164/ajrccm.161.1.9804096.
• [236] Altered cytokine profiles of human retinal pigment epithelium: oxidant injury and replicative senescence. Mol Vis. 2013;19:718-28. Epub 2013 Mar 21.
• [237] Indomethacin and ibuprofen effect on IL-1ra production by mononuclear cells of preterm newborns and adults. Biol Neonate. 2002 Aug;82(2):73-7. doi: 10.1159/000063090.
• [238] Expression profile analysis of human peripheral blood mononuclear cells in response to aspirin. Arch Immunol Ther Exp (Warsz). 2005 Mar-Apr;53(2):151-8.
• [239] Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound. Toxicol In Vitro. 2021 Jun;73:105112. doi: 10.1016/j.tiv.2021.105112. Epub 2021 Feb 22.
• [240] Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
• [241] Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur J Nutr. 2005 Mar;44(3):143-56. doi: 10.1007/s00394-004-0503-1. Epub 2004 Apr 30.
• [242] Thyroid hormone responsive genes in cultured human fibroblasts. J Clin Endocrinol Metab. 2005 Feb;90(2):936-43.
• [243] Regulation of keratinocyte growth factor and scatter factor in cyclosporin-induced gingival overgrowth. J Oral Pathol Med. 2004 Aug;33(7):391-7. doi: 10.1111/j.1600-0714.2004.00223.x.
• [244] Keratinocyte growth factor is upregulated by the hyperplasia-inducing drug nifedipine. Cytokine. 2000 Oct;12(10):1566-9. doi: 10.1006/cyto.2000.0756.
• [245] The effect of DNA methylation inhibitor 5-Aza-2'-deoxycytidine on human endometrial stromal cells. Hum Reprod. 2010 Nov;25(11):2859-69.
• [246] Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling. Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21737-42. doi: 10.1073/pnas.1007863107. Epub 2010 Nov 22.
• [247] Synergistic effects of arsenic trioxide combined with ascorbic acid in human osteosarcoma MG-63 cells: a systems biology analysis. Eur Rev Med Pharmacol Sci. 2014;18(24):3877-88.
• [248] Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
• [249] Adipocyte differentiation, mitochondrial gene expression and fat distribution: differences between zidovudine and tenofovir after 6 months. Antivir Ther. 2009;14(8):1089-100. doi: 10.3851/IMP1457.
• [250] Testosterone stimulates adipose tissue 11beta-hydroxysteroid dehydrogenase type 1 expression in a depot-specific manner in children. J Clin Endocrinol Metab. 2010 Jul;95(7):3300-8.
• [251] Role of calcitriol and cortisol on human adipocyte proliferation and oxidative and inflammatory stress: a microarray study. J Nutrigenet Nutrigenomics. 2008;1(1-2):30-48. doi: 10.1159/000109873. Epub 2007 Oct 16.
• [252] Adenosine receptor expression in rheumatoid synovium: a basis for methotrexate action. Arthritis Res Ther. 2012 Jun 8;14(3):R138. doi: 10.1186/ar3871.
• [253] Integrated analysis of rifampicin-induced microRNA and gene expression changes in human hepatocytes. Drug Metab Pharmacokinet. 2014;29(4):333-40.
• [254] New 2,6,9-trisubstituted adenines as adenosine receptor antagonists: a preliminary SAR profile. Purinergic Signal. 2007 Sep;3(4):339-46. doi: 10.1007/s11302-007-9068-9. Epub 2007 Sep 19.
• [255] Comparative gene expression analysis of a chronic myelogenous leukemia cell line resistant to cyclophosphamide using oligonucleotide arrays and response to tyrosine kinase inhibitors. Leuk Res. 2007 Nov;31(11):1511-20.
• [256] Proteomics-based identification of differentially abundant proteins from human keratinocytes exposed to arsenic trioxide. J Proteomics Bioinform. 2014 Jul;7(7):166-178.
• [257] Docosahexaenoic acid regulates gene expression in HUVEC cells treated with polycyclic aromatic hydrocarbons. Toxicol Lett. 2015 Jul 16;236(2):75-81.
• [258] Etoposide induces necrosis through p53-mediated antiapoptosis in human kidney proximal tubule cells. Toxicol Sci. 2015 Nov;148(1):204-19.
• [259] Conjugated linoleic acid, unlike other unsaturated fatty acids, strongly induces glutathione synthesis without any lipoperoxidation. Br J Nutr. 2006 Nov;96(5):811-9.
• [260] COX-2 and PPAR-gama confer cannabidiol-induced apoptosis of human lung cancer cells. Mol Cancer Ther. 2013 Jan;12(1):69-82.
• [261] Mitochondrial involvement in schizophrenia and other functional psychoses. Neurochem Res. 1996 Sep;21(9):995-1004.
• [262] Immunomodulatory effect of selective serotonin reuptake inhibitors (SSRIs) on human T lymphocyte function and gene expression. Eur Neuropsychopharmacol. 2007 Dec;17(12):774-80.
• [263] Stimulation of cyclooxygenase-2 expression by bone-derived transforming growth factor-beta enhances bone metastases in breast cancer. Cancer Res. 2006 Feb 15;66(4):2067-73.
• [264] Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
• [265] A2E selectively induces cox-2 in ARPE-19 and human neural cells. Curr Eye Res. 2006 Mar;31(3):259-63.
• [266] Primary Human Hepatocyte Spheroids as Tools to Study the Hepatotoxic Potential of Non-Pharmaceutical Chemicals. Int J Mol Sci. 2021 Oct 12;22(20):11005. doi: 10.3390/ijms222011005.
• [267] Oxidative stress triggers STAT3 tyrosine phosphorylation and nuclear translocation in human lymphocytes. J Biol Chem. 1999 Jun 18;274(25):17580-6. doi: 10.1074/jbc.274.25.17580.
• [268] Response rate of fibrosarcoma cells to cytotoxic drugs on the expression level correlates to the therapeutic response rate of fibrosarcomas and is mediated by regulation of apoptotic pathways. BMC Cancer. 2005 Jul 7;5:74. doi: 10.1186/1471-2407-5-74.
• [269] Molecular mechanisms underlying the inhibition of IFN--induced, STAT1-mediated gene transcription in human macrophages by simvastatin and agonists of PPARs and LXRs. J Cell Biochem. 2011 Feb;112(2):675-83. doi: 10.1002/jcb.22976.
• [270] Quercetin and Its Fermented Extract as a Potential Inhibitor of Bisphenol A-Exposed HT-29 Colon Cancer Cells' Viability. Int J Mol Sci. 2023 Mar 15;24(6):5604. doi: 10.3390/ijms24065604.
• [271] 13-cis Retinoic acid induces apoptosis and cell cycle arrest in human SEB-1 sebocytes. J Invest Dermatol. 2006 Oct;126(10):2178-89. doi: 10.1038/sj.jid.5700289. Epub 2006 Mar 30.
• [272] DNA microarray analysis of vitamin D-induced gene expression in a human colon carcinoma cell line. Physiol Genomics. 2004 Apr 13;17(2):122-9. doi: 10.1152/physiolgenomics.00002.2003.
• [273] Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
• [274] Differential expression of microRNAs and their predicted targets in renal cells exposed to amphotericin B and its complex with copper (II) ions. Toxicol Mech Methods. 2017 Sep;27(7):537-543. doi: 10.1080/15376516.2017.1333554. Epub 2017 Jun 8.
• [275] Identification of biomarkers and outcomes of endocrine disruption in human ovarian cortex using In Vitro Models. Toxicology. 2023 Feb;485:153425. doi: 10.1016/j.tox.2023.153425. Epub 2023 Jan 5.
• [276] 5-Fluorouracil: identification of novel downstream mediators of tumour response. Anticancer Res. 2004 Mar-Apr;24(2A):417-23.
• [277] Unique bisphenol A transcriptome in prostate cancer: novel effects on ERbeta expression that correspond to androgen receptor mutation status. Environ Health Perspect. 2007 Nov;115(11):1646-53. doi: 10.1289/ehp.10283.
• [278] Omeprazole inhibits pancreatic cancer cell invasion through a nongenomic aryl hydrocarbon receptor pathway. Chem Res Toxicol. 2015 May 18;28(5):907-18.
• [279] Cannabinoids synergize with carfilzomib, reducing multiple myeloma cells viability and migration. Oncotarget. 2016 Nov 22;7(47):77543-77557. doi: 10.18632/oncotarget.12721.
• [280] Arsenic trioxide inhibits CXCR4-mediated metastasis by interfering miR-520h/PP2A/NF-B signaling in cervical cancer. Ann Surg Oncol. 2014 Dec;21 Suppl 4:S687-95. doi: 10.1245/s10434-014-3812-5. Epub 2014 Jul 22.
• [281] Etodolac induces apoptosis and inhibits cell adhesion to bone marrow stromal cells in human myeloma cells. Leuk Res. 2006 Feb;30(2):123-35. doi: 10.1016/j.leukres.2005.06.009. Epub 2005 Jul 25.
• [282] Chemokine induction by all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia: triggering the differentiation syndrome. Blood. 2009 Dec 24;114(27):5512-21. doi: 10.1182/blood-2009-02-204834. Epub 2009 Oct 14.
• [283] Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
• [284] Moving toward integrating gene expression profiling into high-throughput testing: a gene expression biomarker accurately predicts estrogen receptor alpha modulation in a microarray compendium. Toxicol Sci. 2016 May;151(1):88-103.
• [285] Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity. Toxicology. 2014 Jan 6;315:8-16. doi: 10.1016/j.tox.2013.10.009. Epub 2013 Nov 6.
• [286] Expression of the helix-loop-helix protein inhibitor of DNA binding-1 (ID-1) is activated by all-trans retinoic acid in normal human keratinocytes. Toxicol Appl Pharmacol. 2006 Aug 1;214(3):219-29. doi: 10.1016/j.taap.2005.12.015. Epub 2006 Feb 21.
• [287] Immediate up-regulation of the calcium-binding protein S100P and its involvement in the cytokinin-induced differentiation of human myeloid leukemia cells. Biochim Biophys Acta. 2005 Sep 10;1745(2):156-65.
• [288] Frequent inactivation of RAMP2, EFEMP1 and Dutt1 in lung cancer by promoter hypermethylation. Clin Cancer Res. 2007 Aug 1;13(15 Pt 1):4336-44. doi: 10.1158/1078-0432.CCR-07-0015.
• [289] Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
• [290] Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
• [291] Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
• [292] Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. Arch Toxicol. 2016 Jan;90(1):159-80.
• [293] Identification of biomarkers modulated by the rexinoid LGD1069 (bexarotene) in human breast cells using oligonucleotide arrays. Cancer Res. 2006 Dec 15;66(24):12009-18.
• [294] A comprehensive analysis of Wnt/beta-catenin signaling pathway-related genes and crosstalk pathways in the treatment of As2O3 in renal cancer. Ren Fail. 2018 Nov;40(1):331-339.
• [295] Cdk4/6 inhibition induces epithelial-mesenchymal transition and enhances invasiveness in pancreatic cancer cells. Mol Cancer Ther. 2012 Oct;11(10):2138-48. doi: 10.1158/1535-7163.MCT-12-0562. Epub 2012 Aug 6.
• [296] Exocrine pancreatic carcinogenesis and autotaxin expression. PLoS One. 2012;7(8):e43209. doi: 10.1371/journal.pone.0043209. Epub 2012 Aug 29.
• [297] Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells. Chem Res Toxicol. 2014 Mar 17;27(3):408-20.
• [298] Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell. 2009 Aug 21;138(4):645-659. doi: 10.1016/j.cell.2009.06.034. Epub 2009 Aug 13.
• [299] Arsenic trioxide-induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemia. Leukemia. 2000 Feb;14(2):262-70. doi: 10.1038/sj.leu.2401650.
• [300] 1,25-Dihydroxyvitamin D3 suppresses gene expression of eukaryotic translation initiation factor 2 in human promyelocytic leukemia HL-60 cells. Cell Struct Funct. 2005;30(1):1-6. doi: 10.1247/csf.30.1.
• [301] Fenofibrate induces effective apoptosis in mantle cell lymphoma by inhibiting the TNFalpha/NF-kappaB signaling axis. Leukemia. 2010 Aug;24(8):1476-86. doi: 10.1038/leu.2010.117. Epub 2010 Jun 3.
• [302] Effect of zoledronic acid on oral fibroblasts and epithelial cells: a potential mechanism of bisphosphonate-associated osteonecrosis. Br J Haematol. 2009 Mar;144(5):667-76. doi: 10.1111/j.1365-2141.2008.07504.x. Epub 2008 Nov 20.
• [303] Bone marrow osteoblast damage by chemotherapeutic agents. PLoS One. 2012;7(2):e30758. doi: 10.1371/journal.pone.0030758. Epub 2012 Feb 17.
• [304] Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
• [305] Unique transcriptome, pathways, and networks in the human endometrial fibroblast response to progesterone in endometriosis. Biol Reprod. 2011 Apr;84(4):801-15.
• [306] Transcriptome and DNA methylation changes modulated by sulforaphane induce cell cycle arrest, apoptosis, DNA damage, and suppression of proliferation in human liver cancer cells. Food Chem Toxicol. 2020 Feb;136:111047. doi: 10.1016/j.fct.2019.111047. Epub 2019 Dec 12.
• [307] Motexafin gadolinium disrupts zinc metabolism in human cancer cell lines. Cancer Res. 2005 May 1;65(9):3837-45.
• [308] The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
• [309] Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells. Exp Eye Res. 2009 Dec;89(6):995-1002. doi: 10.1016/j.exer.2009.08.011. Epub 2009 Sep 1.
• [310] Arsenic trioxide induces regulatory functions of plasmacytoid dendritic cells through interferon- inhibition. Acta Pharm Sin B. 2020 Jun;10(6):1061-1072. doi: 10.1016/j.apsb.2020.01.016. Epub 2020 Jan 31.
• [311] Regulation of inflammatory responses in tumor necrosis factor-activated and rheumatoid arthritis synovial macrophages by JAK inhibitors. Arthritis Rheum. 2012 Dec;64(12):3856-66. doi: 10.1002/art.37691.
• [312] Small Molecule Antipsychotic Aripiprazole Potentiates Ozone-Induced Inflammation in Airway Epithelium. Chem Res Toxicol. 2019 Oct 21;32(10):1997-2005. doi: 10.1021/acs.chemrestox.9b00149. Epub 2019 Sep 11.
• [313] Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium. Mol Hum Reprod. 2007 Sep;13(9):641-54.
• [314] Epigenetic silencing of novel tumor suppressors in malignant melanoma. Cancer Res. 2006 Dec 1;66(23):11187-93. doi: 10.1158/0008-5472.CAN-06-1274.
• [315] Effects of lithium and valproic acid on gene expression and phenotypic markers in an NT2 neurosphere model of neural development. PLoS One. 2013;8(3):e58822.
• [316] Cell-type-specific responses to chemotherapeutics in breast cancer. Cancer Res. 2004 Jun 15;64(12):4218-26.
• [317] Cytosine arabinoside induces ectoderm and inhibits mesoderm expression in human embryonic stem cells during multilineage differentiation. Br J Pharmacol. 2011 Apr;162(8):1743-56.
• [318] Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes. J Immunol. 2008 May 15;180(10):6988-96. doi: 10.4049/jimmunol.180.10.6988.
• [319] Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling. J Exp Med. 2009 Mar 16;206(3):535-48. doi: 10.1084/jem.20082293. Epub 2009 Mar 9.
• [320] Induction of heme oxygenase-1 by cobalt protoporphyrin enhances the antitumour effect of bortezomib in adult T-cell leukaemia cells. Br J Cancer. 2007 Oct 22;97(8):1099-105. doi: 10.1038/sj.bjc.6604003. Epub 2007 Sep 25.
• [321] Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92. doi: 10.1016/j.bbrc.2011.08.027. Epub 2011 Aug 16.
• [322] The genomic response of Ishikawa cells to bisphenol A exposure is dose- and time-dependent. Toxicology. 2010 Apr 11;270(2-3):137-49. doi: 10.1016/j.tox.2010.02.008. Epub 2010 Feb 17.
• [323] Growth inhibition of ovarian tumor-initiating cells by niclosamide. Mol Cancer Ther. 2012 Aug;11(8):1703-12.
• [324] Epigenetic changes in individuals with arsenicosis. Chem Res Toxicol. 2011 Feb 18;24(2):165-7. doi: 10.1021/tx1004419. Epub 2011 Feb 4.
• [325] Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
• [326] Mechanisms of indomethacin-induced alterations in the choline phospholipid metabolism of breast cancer cells. Neoplasia. 2006 Sep;8(9):758-71.
• [327] Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. PLoS One. 2012;7(12):e53003. doi: 10.1371/journal.pone.0053003. Epub 2012 Dec 27.
• [328] Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells. J Biol Chem. 2012 Dec 14;287(51):43137-55.
• [329] Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297. doi: 10.1016/j.fct.2020.111297. Epub 2020 Mar 28.
• [330] Bisphenol A and bisphenol S induce distinct transcriptional profiles in differentiating human primary preadipocytes. PLoS One. 2016 Sep 29;11(9):e0163318.
• [331] Actinomycin D inhibits the expression of the cystine/glutamate transporter xCT via attenuation of CD133 synthesis in CD133(+) HCC. Chem Biol Interact. 2019 Aug 25;309:108713. doi: 10.1016/j.cbi.2019.06.026. Epub 2019 Jun 19.
• [332] Transcriptome-based functional classifiers for direct immunotoxicity. Arch Toxicol. 2014 Mar;88(3):673-89.
• [333] Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells. Eur J Pharmacol. 2014 Jun 5;732:60-7.
• [334] Exposure to Insecticides Modifies Gene Expression and DNA Methylation in Hematopoietic Tissues In Vitro. Int J Mol Sci. 2023 Mar 26;24(7):6259. doi: 10.3390/ijms24076259.
• [335] 17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.
• [336] A novel, integrated in vitro carcinogenicity test to identify genotoxic and non-genotoxic carcinogens using human lymphoblastoid cells. Arch Toxicol. 2018 Feb;92(2):935-951. doi: 10.1007/s00204-017-2102-y. Epub 2017 Nov 6.
• [337] A Gene Expression Biomarker Identifies Chemical Modulators of Estrogen Receptor in an MCF-7 Microarray Compendium. Chem Res Toxicol. 2021 Feb 15;34(2):313-329. doi: 10.1021/acs.chemrestox.0c00243. Epub 2021 Jan 6.
• [338] Gene expression profile of multiple myeloma cell line treated by arsenic trioxide. J Huazhong Univ Sci Technolog Med Sci. 2007 Dec;27(6):646-9. doi: 10.1007/s11596-007-0606-z.
• [339] Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
• [340] Inhibition of prostate cancer cell colony formation by the flavonoid quercetin correlates with modulation of specific regulatory genes. Clin Diagn Lab Immunol. 2004 Jan;11(1):63-9. doi: 10.1128/cdli.11.1.63-69.2004.
• [341] Arsenic trioxide induces different gene expression profiles of genes related to growth and apoptosis in glioma cells dependent on the p53 status. Mol Biol Rep. 2008 Sep;35(3):421-9.
• [342] Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNF-mediated hepatotoxicity. Toxicol Sci. 2014 Jul;140(1):144-59. doi: 10.1093/toxsci/kfu072. Epub 2014 Apr 20.
• [343] The effects of dasatinib on IgE receptor-dependent activation and histamine release in human basophils. Blood. 2008 Mar 15;111(6):3097-107.
• [344] Comprehensive analysis of transcriptomic changes induced by low and high doses of bisphenol A in HepG2 spheroids in vitro and rat liver in vivo. Environ Res. 2019 Jun;173:124-134. doi: 10.1016/j.envres.2019.03.035. Epub 2019 Mar 18.
• [345] Stimulus-specific regulation of CD63 and CD203c membrane expression in human basophils by the flavonoid quercetin. Int Immunopharmacol. 2010 Feb;10(2):183-92. doi: 10.1016/j.intimp.2009.10.014. Epub 2009 Nov 1.
• [346] Pharmacogenomic identification of novel determinants of response to chemotherapy in colon cancer. Cancer Res. 2006 Mar 1;66(5):2765-77.
• [347] Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
• [348] Melanoma coordinates general and cell-specific mechanisms to promote methotrexate resistance. Exp Cell Res. 2012 Jun 10;318(10):1146-59.
• [349] Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells. Biol Pharm Bull. 2013;36(6):944-51. doi: 10.1248/bpb.b12-01004.
• [350] Involvement of the activation of Nrf2/HO-1, p38 MAPK signaling pathways and endoplasmic reticulum stress in furazolidone induced cytotoxicity and S phase arrest in human hepatocyte L02 cells: modulation of curcumin. Toxicol Mech Methods. 2017 Mar;27(3):165-172. doi: 10.1080/15376516.2016.1273424. Epub 2017 Jan 8.
• [351] Long-term exposure to zidovudine delays cell cycle progression, induces apoptosis, and decreases telomerase activity in human hepatocytes. Toxicol Sci. 2009 Sep;111(1):120-30. doi: 10.1093/toxsci/kfp136. Epub 2009 Jun 18.
• [352] ATR, PML, and CHK2 play a role in arsenic trioxide-induced apoptosis. J Biol Chem. 2006 Sep 29;281(39):28764-71. doi: 10.1074/jbc.M604392200. Epub 2006 Aug 3.
• [353] Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication. J Biol Chem. 2012 Apr 20;287(17):14289-300. doi: 10.1074/jbc.M112.353201. Epub 2012 Mar 1.
• [354] mTOR inhibition reverses acquired endocrine therapy resistance of breast cancer cells at the cell proliferation and gene-expression levels. Cancer Sci. 2008 Oct;99(10):1992-2003. doi: 10.1111/j.1349-7006.2008.00955.x.
• [355] Time series analysis of oxidative stress response patterns in HepG2: a toxicogenomics approach. Toxicology. 2013 Apr 5;306:24-34.
• [356] Aurora-A overexpression associates with Ha-ras codon-12 mutation and blackfoot disease endemic area in bladder cancer. Cancer Lett. 2006 Sep 8;241(1):93-101. doi: 10.1016/j.canlet.2005.10.014. Epub 2005 Dec 9.
• [357] Targeting iron homeostasis induces cellular differentiation and synergizes with differentiating agents in acute myeloid leukemia. J Exp Med. 2010 Apr 12;207(4):731-50. doi: 10.1084/jem.20091488. Epub 2010 Apr 5.
• [358] Long-term estrogen exposure promotes carcinogen bioactivation, induces persistent changes in gene expression, and enhances the tumorigenicity of MCF-7 human breast cancer cells. Toxicol Appl Pharmacol. 2009 Nov 1;240(3):355-66.
• [359] Effects of acute ethanol treatment on NCCIT cells and NCCIT cell-derived embryoid bodies (EBs). Toxicol In Vitro. 2010 Sep;24(6):1696-704. doi: 10.1016/j.tiv.2010.05.017. Epub 2010 May 26.
• [360] Proteomic analysis of anti-cancer effects by paclitaxel treatment in cervical cancer cells. Gynecol Oncol. 2005 Jul;98(1):45-53. doi: 10.1016/j.ygyno.2005.04.010.
• [361] Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
• [362] Assessment of the cytotoxic, genotoxic, and apoptotic potential of flurbiprofen in HeLa and HepG2 cell lines. J Biochem Mol Toxicol. 2021 Jun;35(6):1-11. doi: 10.1002/jbt.22770. Epub 2021 Mar 11.
• [363] Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
• [364] Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. Br J Dermatol. 2009 Mar;160(3):519-26. doi: 10.1111/j.1365-2133.2008.08931.x. Epub 2008 Nov 25.
• [365] Apoptotic induction by simvastatin in human lung cancer A549 cells via Akt signaling dependent down-regulation of survivin. Invest New Drugs. 2011 Oct;29(5):945-52. doi: 10.1007/s10637-010-9450-2. Epub 2010 May 13.
• [366] Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells. Oncogene. 2005 Sep 15;24(41):6213-21. doi: 10.1038/sj.onc.1208774.
• [367] Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway. Cancer Invest. 2009 Jul;27(6):604-12. doi: 10.1080/07357900802337191.
• [368] Troglitazone sensitizes tumor cells to TRAIL-induced apoptosis via down-regulation of FLIP and Survivin. Apoptosis. 2006 Sep;11(9):1503-12. doi: 10.1007/s10495-006-8896-3.
• [369] Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23. doi: 10.1007/s00204-013-1169-3. Epub 2013 Nov 30.
• [370] Similarities and differences between two modes of antagonism of the thyroid hormone receptor. ACS Chem Biol. 2011 Oct 21;6(10):1096-106.
• [371] A pilot study on the transcriptional response of androgen- and insulin-related genes in peripheral blood mononuclear cells induced by testosterone administration in hypogonadal men. J Biol Regul Homeost Agents. 2011 Apr-Jun;25(2):291-4.
• [372] Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity. Arch Toxicol. 2018 Jan;92(1):469-485.
• [373] Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
• [374] Ciprofloxacin mediates cancer stem cell phenotypes in lung cancer cells through caveolin-1-dependent mechanism. Chem Biol Interact. 2016 Apr 25;250:1-11.
• [375] Enhancement of the antiproliferative activity of gemcitabine by modulation of c-Met pathway in pancreatic cancer. Curr Pharm Des. 2013;19(5):940-50.
• [376] Arsenic oxide targets stem cell marker CD133/prominin-1 in gallbladder carcinoma. Cancer Lett. 2011 Nov 28;310(2):181-7. doi: 10.1016/j.canlet.2011.06.035. Epub 2011 Jul 5.
• [377] Melatonin reduces lung cancer stemness through inhibiting of PLC, ERK, p38, -catenin, and Twist pathways. Environ Toxicol. 2019 Feb;34(2):203-209. doi: 10.1002/tox.22674. Epub 2018 Nov 12.
• [378] Gene expression profiling in Ishikawa cells: a fingerprint for estrogen active compounds. Toxicol Appl Pharmacol. 2009 Apr 1;236(1):85-96.
• [379] The genomic response of a human uterine endometrial adenocarcinoma cell line to 17alpha-ethynyl estradiol. Toxicol Sci. 2009 Jan;107(1):40-55.
• [380] Apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma. PLoS One. 2011;6(8):e23569.
• [381] Characterization of DNA reactive and non-DNA reactive anticancer drugs by gene expression profiling. Mutat Res. 2007 Jun 1;619(1-2):16-29. doi: 10.1016/j.mrfmmm.2006.12.007. Epub 2007 Feb 8.
• [382] Identification of approved drugs as potent inhibitors of pregnane X receptor activation with differential receptor interaction profiles. Arch Toxicol. 2018 Apr;92(4):1435-1451.
• [383] Characterization of drug-specific signaling between primary human hepatocytes and immune cells. Toxicol Sci. 2017 Jul 1;158(1):76-89.
• [384] Oxidative stress mechanisms do not discriminate between genotoxic and nongenotoxic liver carcinogens. Chem Res Toxicol. 2015 Aug 17;28(8):1636-46.
• [385] Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
• [386] Coordinate up-regulation of TMEM97 and cholesterol biosynthesis genes in normal ovarian surface epithelial cells treated with progesterone: implications for pathogenesis of ovarian cancer. BMC Cancer. 2007 Dec 11;7:223.
• [387] Heat shock protein inhibitors, 17-DMAG and KNK437, enhance arsenic trioxide-induced mitotic apoptosis. Toxicol Appl Pharmacol. 2009 Apr 15;236(2):231-8. doi: 10.1016/j.taap.2009.02.003. Epub 2009 Feb 12.
• [388] Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
• [389] Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
• [390] Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2/M arrest and inducing apoptosis. Food Chem Toxicol. 2008 Jun;46(6):2042-53. doi: 10.1016/j.fct.2008.01.049. Epub 2008 Feb 7.
• [391] Endoplasmic reticulum stress contributes to arsenic trioxide-induced intrinsic apoptosis in human umbilical and bone marrow mesenchymal stem cells. Environ Toxicol. 2016 Mar;31(3):314-28.
• [392] Comparison of the global gene expression profiles produced by methylparaben, n-butylparaben and 17beta-oestradiol in MCF7 human breast cancer cells. J Appl Toxicol. 2007 Jan-Feb;27(1):67-77. doi: 10.1002/jat.1200.
• [393] Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions. Toxicol In Vitro. 2009 Apr;23(3):466-75. doi: 10.1016/j.tiv.2008.12.018. Epub 2008 Dec 30.
• [394] Novel functional view of the crocidolite asbestos-treated A549 human lung epithelial transcriptome reveals an intricate network of pathways with opposing functions. BMC Genomics. 2008 Aug 7;9:376.
• [395] Polyunsaturated fatty acids synergize with lipid droplet binding thalidomide analogs to induce oxidative stress in cancer cells. Lipids Health Dis. 2010 Jun 2;9:56. doi: 10.1186/1476-511X-9-56.
• [396] Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 Feb 26;10(1):3450. doi: 10.1038/s41598-020-59827-1.
• [397] Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells. Toxicol Sci. 2011 Mar;120(1):109-22.
• [398] Proteomic analysis of hepatic effects of phenobarbital in mice with humanized liver. Arch Toxicol. 2022 Oct;96(10):2739-2754. doi: 10.1007/s00204-022-03338-7. Epub 2022 Jul 26.
• [399] Regulation of folate-mediated one-carbon metabolism by 10-formyltetrahydrofolate dehydrogenase. J Biol Chem. 2006 Jul 7;281(27):18335-42. doi: 10.1074/jbc.M510623200. Epub 2006 Apr 20.
• [400] Alternatives for the worse: Molecular insights into adverse effects of bisphenol a and substitutes during human adipocyte differentiation. Environ Int. 2021 Nov;156:106730. doi: 10.1016/j.envint.2021.106730. Epub 2021 Jun 27.
• [401] Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029.
• [402] Endometrial receptivity is affected in women with high circulating progesterone levels at the end of the follicular phase: a functional genomics analysis. Hum Reprod. 2011 Jul;26(7):1813-25.
• [403] Quercetin induced cell apoptosis and altered gene expression in AGS human gastric cancer cells. Environ Toxicol. 2018 Nov;33(11):1168-1181. doi: 10.1002/tox.22623. Epub 2018 Aug 27.
• [404] How benzene and its metabolites affect human marrow derived mesenchymal stem cells. Toxicol Lett. 2012 Oct 17;214(2):145-53. doi: 10.1016/j.toxlet.2012.08.015. Epub 2012 Aug 30.
• [405] Identification of biomarkers for the initiation of apoptosis in human preneoplastic colonocytes by proteome analysis. Int J Cancer. 2004 Mar 20;109(2):220-9. doi: 10.1002/ijc.11692.
• [406] Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens. Food Chem Toxicol. 2009 Apr;47(4):787-95.
• [407] Gene microarray analysis of human renal cell carcinoma: the effects of HDAC inhibition and retinoid treatment. Cancer Biol Ther. 2008 Oct;7(10):1607-18.
• [408] Aberrantly expressed genes in HaCaT keratinocytes chronically exposed to arsenic trioxide. Biomark Insights. 2011 Feb 8;6:7-16.
• [409] Emetine inhibits migration and invasion of human non-small-cell lung cancer cells via regulation of ERK and p38 signaling pathways. Chem Biol Interact. 2015 Dec 5;242:25-33. doi: 10.1016/j.cbi.2015.08.014. Epub 2015 Aug 30.
• [410] Zidovudine induces S-phase arrest and cell cycle gene expression changes in human cells. Mutagenesis. 2005 Mar;20(2):139-46. doi: 10.1093/mutage/gei019. Epub 2005 Mar 22.
• [411] In vitro effects of aldehydes present in tobacco smoke on gene expression in human lung alveolar epithelial cells. Toxicol In Vitro. 2013 Apr;27(3):1072-81.
• [412] Sevoflurane but not propofol enhances ovarian cancer cell biology through regulating cellular metabolic and signaling mechanisms. Cell Biol Toxicol. 2023 Aug;39(4):1395-1411. doi: 10.1007/s10565-022-09766-6. Epub 2022 Oct 8.
• [413] Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
• [414] Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1. FASEB J. 2012 Apr;26(4):1535-48. doi: 10.1096/fj.11-198184. Epub 2011 Dec 23.
• [415] Discovery of molecular mechanisms of neuroprotection using cell-based bioassays and oligonucleotide arrays. Physiol Genomics. 2002 Oct 29;11(2):45-52. doi: 10.1152/physiolgenomics.00064.2002.
• [416] Inhibition of invasion and induction of apoptosis by selenium in human malignant brain tumour cells in vitro. Int J Oncol. 2007 May;30(5):1263-71.
• [417] Dietary supplementation with the anti-tumour promoter quercetin: its effects on matrix metalloproteinase gene regulation. Mutat Res. 2001 Sep 1;480-481:269-76. doi: 10.1016/s0027-5107(01)00184-1.
• [418] Arsenic trioxide (As2O3) inhibits invasion of HT1080 human fibrosarcoma cells: role of nuclear factor-kappaB and reactive oxygen species. J Cell Biochem. 2005 Aug 1;95(5):955-69. doi: 10.1002/jcb.20452.
• [419] Aspirin inhibits MMP-2 and MMP-9 expressions and activities through upregulation of PPARalpha/gamma and TIMP gene expressions in ox-LDL-stimulated macrophages derived from human monocytes. Pharmacology. 2009;83(1):18-25. doi: 10.1159/000166183. Epub 2008 Oct 30.
• [420] Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
• [421] Effects of aspirin on metastasis-associated gene expression detected by cDNA microarray. Acta Pharmacol Sin. 2004 Oct;25(10):1327-33.
• [422] Selection of drugs to test the specificity of the Tg.AC assay by screening for induction of the gadd153 promoter in vitro. Toxicol Sci. 2003 Aug;74(2):260-70. doi: 10.1093/toxsci/kfg113. Epub 2003 May 2.
• [423] Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
• [424] Methotrexate induces production of IL-1 and IL-6 in the monocytic cell line U937. Arthritis Res Ther. 2014 Jan 20;16(1):R17. doi: 10.1186/ar4444.
• [425] Simvastatin inhibits NOR-1 expression induced by hyperlipemia by interfering with CREB activation. Cardiovasc Res. 2005 Aug 1;67(2):333-41. doi: 10.1016/j.cardiores.2005.03.016. Epub 2005 Apr 21.
• [426] The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells. J Biol Chem. 2004 Jun 25;279(26):27008-16. doi: 10.1074/jbc.M403588200. Epub 2004 Apr 16.
• [427] Oxidative stress in kidney transplant patients with calcineurin inhibitor-induced hypertension: effect of ramipril. J Cardiovasc Pharmacol. 2002 Oct;40(4):625-31.
• [428] Transcriptomic Analysis of Stem Cells Treated with Moringin or Cannabidiol: Analogies and Differences in Inflammation Pathways. Int J Mol Sci. 2019 Nov 30;20(23):6039. doi: 10.3390/ijms20236039.
• [429] Antiestrogens induce transforming growth factor beta-mediated immunosuppression in breast cancer. Cancer Res. 2010 Feb 15;70(4):1314-22. doi: 10.1158/0008-5472.CAN-09-3292. Epub 2010 Feb 9.
• [430] PPAR-alpha ligands inhibit H2O2-mediated activation of transforming growth factor-beta1 in human mesangial cells. Antioxid Redox Signal. 2002 Dec;4(6):877-84. doi: 10.1089/152308602762197416.
• [431] Cannabidiol selectively modulates interleukin (IL)-1 and IL-6 production in toll-like receptor activated human peripheral blood monocytes. Toxicology. 2021 Dec;464:153016. doi: 10.1016/j.tox.2021.153016. Epub 2021 Nov 2.
• [432] Cytokine abnormalities in a patient with eosinophilic fasciitis. Ann Allergy Asthma Immunol. 2003 Apr;90(4):452-5. doi: 10.1016/S1081-1206(10)61832-7.
• [433] Ciprofloxacin decreases survival in HT-29 cells via the induction of TGF-beta1 secretion and enhances the anti-proliferative effect of 5-fluorouracil. Br J Pharmacol. 2009 Jun;157(3):362-70. doi: 10.1111/j.1476-5381.2009.00161.x. Epub 2009 Apr 9.
• [434] Enhanced apoptosis and transforming growth factor-beta1 expression in colorectal adenomas and carcinomas after Sulindac therapy. Dis Colon Rectum. 2001 Jul;44(7):1008-15. doi: 10.1007/BF02235490.
• [435] Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity. Cell Biol Toxicol. 2021 Apr;37(2):151-175. doi: 10.1007/s10565-020-09537-1. Epub 2020 Jun 14.
• [436] Linalool is a PPARalpha ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome. J Lipid Res. 2014 Jun;55(6):1098-110.
• [437] Moderation of the platelet releasate response by aspirin. Blood. 2007 Jun 1;109(11):4786-92. doi: 10.1182/blood-2006-07-038539. Epub 2007 Feb 15.
• [438] High folic acid increases cell turnover and lowers differentiation and iron content in human HT29 colon cancer cells. Br J Nutr. 2008 Apr;99(4):703-8.
• [439] Gene expression data from acetaminophen-induced toxicity in human hepatic in vitro systems and clinical liver samples. Data Brief. 2016 Mar 26;7:1052-1057. doi: 10.1016/j.dib.2016.03.069. eCollection 2016 Jun.
• [440] Effects of enalapril maleate on blood pressure, renin-angiotensin-aldosterone system, and peripheral sympathetic activity in essential hypertension. Clin Ther. 1987;9(4):390-9.
• [441] Valsartan improves adipose tissue function in humans with impaired glucose metabolism: a randomized placebo-controlled double-blind trial. PLoS One. 2012;7(6):e39930. doi: 10.1371/journal.pone.0039930. Epub 2012 Jun 29.
• [442] The thioxotriazole copper(II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cells. J Biol Chem. 2009 Sep 4;284(36):24306-19.
• [443] Desmosterol can replace cholesterol in sustaining cell proliferation and regulating the SREBP pathway in a sterol-Delta24-reductase-deficient cell line. Biochem J. 2009 May 13;420(2):305-15.
• [444] Differential regulation of apolipoprotein B secretion from HepG2 cells by two HMG-CoA reductase inhibitors, atorvastatin and simvastatin. J Lipid Res. 1999 Jun;40(6):1078-89.
• [445] Alternative splicing of 3-hydroxy-3-methylglutaryl coenzyme A reductase is associated with plasma low-density lipoprotein cholesterol response to simvastatin. Circulation. 2008 Jul 22;118(4):355-62. doi: 10.1161/CIRCULATIONAHA.108.773267. Epub 2008 Jun 16.
• [446] Low-expressional IGF1 mediated methimazole-induced liver developmental toxicity in fetal mice. Toxicology. 2018 Sep 1;408:70-79. doi: 10.1016/j.tox.2018.07.004. Epub 2018 Jul 7.
• [447] Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics. Sci Rep. 2023 Jun 29;13(1):10519. doi: 10.1038/s41598-023-37488-0.
• [448] PPAR gamma ligands, troglitazone and pioglitazone, up-regulate expression of HMG-CoA synthase and HMG-CoA reductase gene in THP-1 macrophages. FEBS Lett. 2002 Jun 5;520(1-3):177-81.
• [449] Ramipril inhibits in vitro human mesangial cell proliferation and platelet-derived growth factor expression. Exp Nephrol. 1999 May-Jun;7(3):229-35. doi: 10.1159/000020606.
• [450] Atheroprotective effect of estriol and estrone sulfate on human vascular smooth muscle cells. J Steroid Biochem Mol Biol. 2000 Jan-Feb;72(1-2):71-8. doi: 10.1016/s0960-0760(99)00149-1.
• [451] AZT-induced hypermethylation of human thymidine kinase gene in the absence of total DNA hypermethylation. FEBS Lett. 1996 Nov 4;396(2-3):323-6. doi: 10.1016/0014-5793(96)01124-6.
• [452] Fluorodeoxyuridine modulates cellular expression of the DNA base excision repair enzyme uracil-DNA glycosylase. Cancer Res. 2006 Sep 1;66(17):8829-37. doi: 10.1158/0008-5472.CAN-06-0540.
• [453] Delivery method, target gene structure, and growth properties of target cells impact mutagenic responses to reactive nitrogen and oxygen species. Chem Res Toxicol. 2012 Apr 16;25(4):873-83. doi: 10.1021/tx2004882. Epub 2012 Feb 21.
• [454] Development of an integrated assay in human TK6 cells to permit comprehensive genotoxicity analysis in vitro. Mutat Res Genet Toxicol Environ Mutagen. 2020 Jan;849:503129. doi: 10.1016/j.mrgentox.2019.503129. Epub 2019 Dec 27.
• [455] E2F1 downregulation by arsenic trioxide in lung adenocarcinoma. Int J Oncol. 2014 Nov;45(5):2033-43. doi: 10.3892/ijo.2014.2609. Epub 2014 Aug 19.
• [456] Decrease of plasminogen activator inhibitor-1 may contribute to the anti-invasive action of cannabidiol on human lung cancer cells. Pharm Res. 2010 Oct;27(10):2162-74. doi: 10.1007/s11095-010-0219-2. Epub 2010 Jul 29.
• [457] Effect of spironolactone on impaired fibrinolysis of hypertensive patients. Kidney Blood Press Res. 2002;25(4):260-4. doi: 10.1159/000066348.
• [458] Association of cell cycle arrest with anticancer drug-induced epithelial-mesenchymal transition in alveolar epithelial cells. Toxicology. 2019 Aug 1;424:152231. doi: 10.1016/j.tox.2019.06.002. Epub 2019 Jun 4.
• [459] Simvastatin inhibits tissue factor and plasminogen activator inhibitor-1 secretion by peripheral blood mononuclear cells in patients with primary nephrotic syndrome. Eur J Med Res. 2007 May 29;12(5):216-21.
• [460] Polyphenols downregulate PAI-1 gene expression in cultured human coronary artery endothelial cells: molecular contributor to cardiovascular protection. Thromb Res. 2007;121(1):59-65. doi: 10.1016/j.thromres.2007.02.001. Epub 2007 Mar 26.
• [461] Troglitazone reduces plasminogen activator inhibitor-1 expression and secretion in cultured human adipocytes. Diabetologia. 2000 Mar;43(3):377-83. doi: 10.1007/s001250050057.
• [462] High-dose mitoxantrone induces programmed cell death or apoptosis in human myeloid leukemia cells. Blood. 1993 Nov 15;82(10):3133-40.
• [463] Inhibition of autophagic flux differently modulates cannabidiol-induced death in 2D and 3D glioblastoma cell cultures. Sci Rep. 2020 Feb 14;10(1):2687. doi: 10.1038/s41598-020-59468-4.
• [464] Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res. 2002 Aug 1;62(15):4419-26.
• [465] Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cells. J Biol Chem. 2002 Nov 15;277(46):43648-58. doi: 10.1074/jbc.M203214200. Epub 2002 Sep 6.
• [466] [Regulation mechanism of autophagy-related protein LC3 by c-Jun in methotrexate resistant human choriocarcinoma JEG-3 cells]. Zhonghua Fu Chan Ke Za Zhi. 2014 Jul;49(7):531-5.
• [467] Structure-based investigation on the binding interaction of hydroxylated polybrominated diphenyl ethers with thyroxine transport proteins. Toxicology. 2010 Nov 9;277(1-3):20-8. doi: 10.1016/j.tox.2010.08.012. Epub 2010 Sep 8.
• [468] Thyroid function and plasma concentrations of polyhalogenated compounds in Inuit adults. Environ Health Perspect. 2009 Sep;117(9):1380-6. doi: 10.1289/ehp.0900633. Epub 2009 May 12.
• [469] G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently. J Biol Chem. 1993 Apr 15;268(11):8298-308.
• [470] Selenite and selenomethionine promote HL-60 cell cycle progression. J Nutr. 2002 Apr;132(4):674-9. doi: 10.1093/jn/132.4.674.
• [471] Differential gene expression of sulindac-treated human breast epithelial cells. Int J Oncol. 2005 Dec;27(6):1727-36.
• [472] Transcriptional profiling of genes induced in the livers of patients treated with carbamazepine. Clin Pharmacol Ther. 2006 Nov;80(5):440-456.
• [473] Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins. Cell Biol Toxicol. 2012 Apr;28(2):69-87.
• [474] Sp1 and Sp3 transcription factors regulate the basal expression of human microsomal epoxide hydrolase (EPHX1) through interaction with the E1b far upstream promoter. Gene. 2014 Feb 15;536(1):135-44. doi: 10.1016/j.gene.2013.11.053. Epub 2013 Dec 4.
• [475] In vitro detection of drug-induced phospholipidosis using gene expression and fluorescent phospholipid based methodologies. Toxicol Sci. 2007 Sep;99(1):162-73.
• [476] Species-specific toxicity of diclofenac and troglitazone in primary human and rat hepatocytes. Chem Biol Interact. 2009 Apr 15;179(1):17-24.
• [477] Phenytoin and cyclosporin A suppress the expression of MMP-1, TIMP-1, and cathepsin L, but not cathepsin B in cultured gingival fibroblasts. J Periodontol. 2000 Jun;71(6):955-60. doi: 10.1902/jop.2000.71.6.955.
• [478] The antimalarial amodiaquine causes autophagic-lysosomal and proliferative blockade sensitizing human melanoma cells to starvation- and chemotherapy-induced cell death. Autophagy. 2013 Dec;9(12):2087-102. doi: 10.4161/auto.26506. Epub 2013 Oct 8.
• [479] A role for the autophagy regulator Transcription Factor EB in amiodarone-induced phospholipidosis. Biochem Pharmacol. 2015 Jun 1;95(3):201-9. doi: 10.1016/j.bcp.2015.03.017. Epub 2015 Apr 13.
• [480] Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray. Cancer Sci. 2006 Jan;97(1):64-71.
• [481] Gingival Stromal Cells as an In Vitro Model: Cannabidiol Modulates Genes Linked With Amyotrophic Lateral Sclerosis. J Cell Biochem. 2017 Apr;118(4):819-828. doi: 10.1002/jcb.25757. Epub 2016 Nov 28.
• [482] Proton pump inhibitors interfere with the anti-tumor potency of RC48ADC. Toxicol In Vitro. 2022 Mar;79:105292. doi: 10.1016/j.tiv.2021.105292. Epub 2021 Dec 3.
• [483] Pyrimethamine induces apoptosis of melanoma cells via a caspase and cathepsin double-edged mechanism. Cancer Res. 2008 Jul 1;68(13):5291-300. doi: 10.1158/0008-5472.CAN-08-0222.
• [484] Synergistic effects of arsenic trioxide and silibinin on apoptosis and invasion in human glioblastoma U87MG cell line. Neurochem Res. 2012 Feb;37(2):370-80. doi: 10.1007/s11064-011-0620-1. Epub 2011 Oct 4.
• [485] Thyroid organotypic rat and human cultures used to investigate drug effects on thyroid function, hormone synthesis and release pathways. Toxicol Appl Pharmacol. 2012 Apr 1;260(1):81-8. doi: 10.1016/j.taap.2012.01.029. Epub 2012 Feb 8.
• [486] Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization. Autophagy. 2016 Nov;12(11):2213-2229. doi: 10.1080/15548627.2016.1213927. Epub 2016 Sep 16.
• [487] Melatonin attenuates cisplatin-induced HepG2 cell death via the regulation of mTOR and ERCC1 expressions. World J Hepatol. 2014 Apr 27;6(4):230-42. doi: 10.4254/wjh.v6.i4.230.
• [488] Pemetrexed downregulates ERCC1 expression and enhances cytotoxicity effected by resveratrol in human nonsmall cell lung cancer cells. Naunyn Schmiedebergs Arch Pharmacol. 2013 Dec;386(12):1047-59. doi: 10.1007/s00210-013-0905-9. Epub 2013 Aug 3.
• [489] Combination of oxaliplatin and irinotecan on human colon cancer cell lines: activity in vitro and in vivo. Anticancer Drugs. 2001 Oct;12(9):741-51. doi: 10.1097/00001813-200110000-00006.
• [490] DNA demethylation by 5-aza-2-deoxycytidine treatment abrogates 17 beta-estradiol-induced cell growth and restores expression of DNA repair genes in human breast cancer cells. Cancer Lett. 2012 Mar;316(1):62-9. doi: 10.1016/j.canlet.2011.10.022. Epub 2011 Oct 23.
• [491] Cytoskeletal activation and altered gene expression in endothelial barrier regulation by simvastatin. Am J Respir Cell Mol Biol. 2004 May;30(5):662-70. doi: 10.1165/rcmb.2003-0267OC. Epub 2003 Nov 20.
• [492] N-acylation of glucosamine modulates chondrocyte growth, proteoglycan synthesis, and gene expression. J Rheumatol. 2005 Sep;32(9):1775-86.
• [493] Combination of atorvastatin and celecoxib synergistically induces cell cycle arrest and apoptosis in colon cancer cells. Int J Cancer. 2008 May 1;122(9):2115-24. doi: 10.1002/ijc.23315.
• [494] Ciprofloxacin enhances the stimulation of matrix metalloproteinase 3 expression by interleukin-1beta in human tendon-derived cells. A potential mechanism of fluoroquinolone-induced tendinopathy. Arthritis Rheum. 2002 Nov;46(11):3034-40. doi: 10.1002/art.10617.
• [495] Reduction of synovial sublining layer inflammation and proinflammatory cytokine expression in psoriatic arthritis treated with methotrexate. Arthritis Rheum. 2004 Oct;50(10):3286-95. doi: 10.1002/art.20518.
• [496] Quercetin inhibits IL-1-induced proliferation and production of MMPs, COX-2, and PGE2 by rheumatoid synovial fibroblast. Inflammation. 2012 Aug;35(4):1585-94. doi: 10.1007/s10753-012-9473-2.
• [497] Rofecoxib regulates the expression of genes related to the matrix metalloproteinase pathway in humans: implication for the adverse effects of cyclooxygenase-2 inhibitors. Clin Pharmacol Ther. 2006 Apr;79(4):303-15. doi: 10.1016/j.clpt.2005.12.306.
• [498] Real-time PCR analysis of the apoptosis related genes in ATRA treated APL t(15;17) patients. Exp Mol Med. 2003 Oct 31;35(5):454-9. doi: 10.1038/emm.2003.59.
• [499] Epigenetic activation of O-linked -N-acetylglucosamine transferase overrides the differentiation blockage in acute leukemia. EBioMedicine. 2020 Apr;54:102678. doi: 10.1016/j.ebiom.2020.102678. Epub 2020 Apr 6.
• [500] Histamine downregulates CD14 expression via H2 receptors on human monocytes. Clin Immunol. 2003 Sep;108(3):274-81. doi: 10.1016/s1521-6616(03)00140-2.
• [501] The anti-proliferative effect of calcitriol on HL-60 cells is neutralized by uraemic biological fluids. Nephrol Dial Transplant. 2001 Feb;16(2):246-52. doi: 10.1093/ndt/16.2.246.
• [502] Dimethyl Fumarate Therapy Significantly Improves the Responsiveness of T Cells in Multiple Sclerosis Patients for Immunoregulation by Regulatory T Cells. Int J Mol Sci. 2017 Jan 28;18(2):271. doi: 10.3390/ijms18020271.
• [503] In vitro antitumoral effects of the steroid ouabain on human thyroid papillary carcinoma cell lines. Environ Toxicol. 2021 Jul;36(7):1338-1348. doi: 10.1002/tox.23130. Epub 2021 Mar 24.
• [504] Cell-based and cytokine-directed chemical screen to identify potential anti-multiple myeloma agents. Leuk Res. 2010 Jul;34(7):917-24. doi: 10.1016/j.leukres.2009.12.002. Epub 2010 Feb 8.
• [505] Structural and functional studies on the human hepatic interleukin-6 receptor. Molecular cloning and overexpression in HepG2 cells. Biochem J. 1991 Aug 1;277 ( Pt 3)(Pt 3):659-64. doi: 10.1042/bj2770659.
• [506] Gene expression profiling of human peri-implantation endometria between natural and stimulated cycles. Fertil Steril. 2008 Dec;90(6):2152-64.
• [507] Gene expression profile induced by BCNU in human glioma cell lines with differential MGMT expression. J Neurooncol. 2005 Jul;73(3):189-98.
• [508] Effects of chlorpromazine with and without UV irradiation on gene expression of HepG2 cells. Mutat Res. 2005 Aug 4;575(1-2):47-60. doi: 10.1016/j.mrfmmm.2005.03.002. Epub 2005 Apr 26.
• [509] Analysis of gene expression induced by diethylstilbestrol (DES) in human primitive Mullerian duct cells using microarray. Cancer Lett. 2005 Apr 8;220(2):197-210.
• [510] Ornithine decarboxylase antizyme upregulates DNA-dependent protein kinase and enhances the nonhomologous end-joining repair of DNA double-strand breaks in human oral cancer cells. Biochemistry. 2007 Aug 7;46(31):8920-32. doi: 10.1021/bi7000328. Epub 2007 Jul 14.
• [511] Cell cycle and anti-estrogen effects synergize to regulate cell proliferation and ER target gene expression. PLoS One. 2010 Jun 8;5(6):e11011. doi: 10.1371/journal.pone.0011011.
• [512] Convergent transcriptional profiles induced by endogenous estrogen and distinct xenoestrogens in breast cancer cells. Carcinogenesis. 2006 Aug;27(8):1567-78.
• [513] Proteomic profile of aminoglutethimide-induced apoptosis in HL-60 cells: role of myeloperoxidase and arylamine free radicals. Chem Biol Interact. 2015 Sep 5;239:129-38.
• [514] Regulation of lipocalin-2 gene by the cancer chemopreventive retinoid 4-HPR. Int J Cancer. 2006 Oct 1;119(7):1599-606.
• [515] Development and validation of the TGx-HDACi transcriptomic biomarker to detect histone deacetylase inhibitors in human TK6 cells. Arch Toxicol. 2021 May;95(5):1631-1645. doi: 10.1007/s00204-021-03014-2. Epub 2021 Mar 26.
• [516] Kinetic analysis of the liver-type (GLUT2) and brain-type (GLUT3) glucose transporters in Xenopus oocytes: substrate specificities and effects of transport inhibitors. Biochem J. 1993 Mar 15;290 ( Pt 3)(Pt 3):701-6. doi: 10.1042/bj2900701.
• [517] In vitro study of transporters involved in intestinal absorption of inorganic arsenic. Chem Res Toxicol. 2012 Feb 20;25(2):446-53. doi: 10.1021/tx200491f. Epub 2012 Jan 26.
• [518] Involvement of pregnane X receptor in the impaired glucose utilization induced by atorvastatin in hepatocytes. Biochem Pharmacol. 2016 Jan 15;100:98-111.
• [519] Mechanisms of peripheral neuropathy associated with bortezomib and vincristine in patients with newly diagnosed multiple myeloma: a prospective analysis of data from the HOVON-65/GMMG-HD4 trial. Lancet Oncol. 2010 Nov;11(11):1057-65. doi: 10.1016/S1470-2045(10)70206-0. Epub 2010 Sep 21.
• [520] Resveratrol attenuates senescence of adipose-derived mesenchymal stem cells and restores their paracrine effects on promoting insulin secretion of INS-1 cells through Pim-1. Eur Rev Med Pharmacol Sci. 2016;20(6):1203-13.
• [521] Thalidomide alters c-MYB and PIM-1 signaling in K-562 cells. Pharmacol Res. 2006 Aug;54(2):91-6. doi: 10.1016/j.phrs.2006.02.010. Epub 2006 Mar 8.
• [522] Incidence of mutation and deletion in topoisomerase II alpha mRNA of etoposide and mAMSA-resistant cell lines. Jpn J Cancer Res. 2001 Oct;92(10):1133-7. doi: 10.1111/j.1349-7006.2001.tb01069.x.
• [523] HU-331 and Oxidized Cannabidiol Act as Inhibitors of Human Topoisomerase II and . Chem Res Toxicol. 2018 Feb 19;31(2):137-144. doi: 10.1021/acs.chemrestox.7b00302. Epub 2018 Jan 8.
• [524] Interactions between the etoposide derivative F14512 and human type II topoisomerases: implications for the C4 spermine moiety in promoting enzyme-mediated DNA cleavage. Biochemistry. 2011 Apr 19;50(15):3240-9. doi: 10.1021/bi200094z. Epub 2011 Mar 28.
• [525] The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib. Toxicol Sci. 2023 Dec 21;197(1):69-78. doi: 10.1093/toxsci/kfad099.
• [526] Arsenic trioxide exposure to ovarian carcinoma cells leads to decreased level of topoisomerase II and cytotoxicity. Int J Gynecol Cancer. 2006 Jul-Aug;16(4):1552-6. doi: 10.1111/j.1525-1438.2006.00626.x.
• [527] Ribavirin inhibits colorectal cancer growth by downregulating PRMT5 expression and H3R8me2s and H4R3me2s accumulation. Toxicol Appl Pharmacol. 2021 Mar 15;415:115450. doi: 10.1016/j.taap.2021.115450. Epub 2021 Feb 9.
• [528] Combining kallistatin gene therapy and meloxicam to treat hepatocellular carcinoma in mice. Cancer Sci. 2009 Nov;100(11):2226-33. doi: 10.1111/j.1349-7006.2009.01306.x. Epub 2009 Aug 4.
• [529] Epinephrine facilitates the growth of T cell lymphoma by altering cell proliferation, apoptosis, and glucose metabolism. Chem Biol Interact. 2023 Jan 5;369:110278. doi: 10.1016/j.cbi.2022.110278. Epub 2022 Nov 22.
• [530] Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells. Nat Commun. 2018 Aug 9;9(1):3069. doi: 10.1038/s41467-018-05402-2.
• [531] Genomic and proteomic analysis of the effects of cannabinoids on normal human astrocytes. Brain Res. 2008 Jan 29;1191:1-11.
• [532] Zinc induces chemokine and inflammatory cytokine release from human promonocytes. J Hazard Mater. 2011 Nov 30;196:335-41. doi: 10.1016/j.jhazmat.2011.09.035. Epub 2011 Sep 19.
• [533] Direct and indirect effects of androgens on survival of hematopoietic progenitor cells in vitro. J Korean Med Sci. 2005 Jun;20(3):409-16. doi: 10.3346/jkms.2005.20.3.409.
• [534] Isoproterenol effects evaluated in heart slices of human and rat in comparison to rat heart in vivo. Toxicol Appl Pharmacol. 2014 Jan 15;274(2):302-12.
• [535] Ciprofloxacin mediated cell growth inhibition, S/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line. Clin Cancer Res. 2000 Mar;6(3):891-900.
• [536] Synthesis and antitumor evaluation of nitrovinyl biphenyls: anticancer agents based on allocolchicines. ChemMedChem. 2011 May 2;6(5):859-68. doi: 10.1002/cmdc.201100019. Epub 2011 Apr 6.
• [537] Arsenic trioxide induces differentiation of cancer stem cells in hepatocellular carcinoma through inhibition of LIF/JAK1/STAT3 and NF-kB signaling pathways synergistically. Clin Transl Med. 2021 Feb;11(2):e335. doi: 10.1002/ctm2.335.
• [538] Antitumor effect of aspirin in glioblastoma cells by modulation of -catenin/T-cell factor-mediated transcriptional activity. J Neurosurg. 2011 Oct;115(4):780-8. doi: 10.3171/2011.5.JNS113. Epub 2011 Jul 1.
• [539] JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Oncogene. 2008 Aug 28;27(37):5033-44.
• [540] Hsa-let-7g miRNA regulates the anti-tumor effects of gastric cancer cells under oxidative stress through the expression of DDR genes. J Toxicol Sci. 2015 Jun;40(3):329-38. doi: 10.2131/jts.40.329.
• [541] Inhibition of cardiomyocyte differentiation of human induced pluripotent stem cells by Ribavirin: Implication for its cardiac developmental toxicity. Toxicology. 2020 Apr 15;435:152422. doi: 10.1016/j.tox.2020.152422. Epub 2020 Feb 26.
• [542] Synthesis and structure-activity relationships of new antiproliferative and proapoptotic retinoid-related biphenyl-4-yl-acrylic acids. Bioorg Med Chem. 2007 Jul 15;15(14):4863-75. doi: 10.1016/j.bmc.2007.04.057. Epub 2007 May 3.
• [543] Methotrexate induces apoptosis through p53/p21-dependent pathway and increases E-cadherin expression through downregulation of HDAC/EZH2. Biochem Pharmacol. 2011 Feb 15;81(4):510-7. doi: 10.1016/j.bcp.2010.11.014. Epub 2010 Nov 27.
• [544] Simvastatin and purine analogs have a synergic effect on apoptosis of chronic lymphocytic leukemia cells. Ann Hematol. 2010 Nov;89(11):1115-24. doi: 10.1007/s00277-010-0988-z. Epub 2010 May 25.
• [545] The isoflavonoids genistein and quercetin activate different stress signaling pathways as shown by analysis of site-specific phosphorylation of ATM, p53 and histone H2AX. DNA Repair (Amst). 2004 Mar 4;3(3):235-44. doi: 10.1016/j.dnarep.2003.10.014.
• [546] Consequences of the natural retinoid/retinoid X receptor ligands action in human breast cancer MDA-MB-231 cell line: Focus on functional proteomics. Toxicol Lett. 2017 Nov 5;281:26-34. doi: 10.1016/j.toxlet.2017.09.001. Epub 2017 Sep 5.
• [547] Protein expression profiling identifies molecular targets of quercetin as a major dietary flavonoid in human colon cancer cells. Proteomics. 2004 Jul;4(7):2160-74.
• [548] Stathmin is involved in arsenic trioxide-induced apoptosis in human cervical cancer cell lines via PI3K linked signal pathway. Cancer Biol Ther. 2010 Sep 15;10(6):632-43. doi: 10.4161/cbt.10.6.12654. Epub 2010 Sep 13.
• [549] Selenium is critical for cancer-signaling gene expression but not cell proliferation in human colon Caco-2 cells. Biofactors. 2007;31(3-4):155-64. doi: 10.1002/biof.5520310302.
• [550] Quercetin regulates insulin like growth factor signaling and induces intrinsic and extrinsic pathway mediated apoptosis in androgen independent prostate cancer cells (PC-3). Mol Cell Biochem. 2010 Nov;344(1-2):173-84. doi: 10.1007/s11010-010-0540-4. Epub 2010 Jul 25.
• [551] Curcumin reduces the expression of survivin, leading to enhancement of arsenic trioxide-induced apoptosis in myelodysplastic syndrome and leukemia stem-like cells. Oncol Rep. 2016 Sep;36(3):1233-42. doi: 10.3892/or.2016.4944. Epub 2016 Jul 15.
• [552] DHT and testosterone, but not DHEA or E2, differentially modulate IGF-I, IGFBP-2, and IGFBP-3 in human prostatic stromal cells. Am J Physiol Endocrinol Metab. 2006 May;290(5):E952-60. doi: 10.1152/ajpendo.00451.2005. Epub 2005 Dec 20.
• [553] Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model. Toxicol In Vitro. 2009 Oct;23(7):1387-95.
• [554] D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis. Apoptosis. 2012 Oct;17(10):1079-94.
• [555] The retinoid anticancer signal: mechanisms of target gene regulation. Br J Cancer. 2005 Aug 8;93(3):310-8. doi: 10.1038/sj.bjc.6602700.
• [556] Gene expression changes in human small airway epithelial cells exposed to Delta9-tetrahydrocannabinol. Toxicol Lett. 2005 Aug 14;158(2):95-107.
• [557] Mebendazole targets essential proteins in glucose metabolism leading gastric cancer cells to death. Toxicol Appl Pharmacol. 2023 Sep 15;475:116630. doi: 10.1016/j.taap.2023.116630. Epub 2023 Jul 18.
• [558] Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain. Toxicol Lett. 2015 Apr 16;234(2):139-50.
• [559] Iron-mediated H2O2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha-induced but not interleukin-1beta-induced IkappaB kinase complex/nuclear factor-kappaB activation. J Biol Chem. 2005 Jan 28;280(4):2912-23. doi: 10.1074/jbc.M409524200. Epub 2004 Nov 17.
• [560] Suppression of mammary carcinoma growth by retinoic acid: proapoptotic genes are targets for retinoic acid receptor and cellular retinoic acid-binding protein II signaling. Cancer Res. 2005 Sep 15;65(18):8193-9. doi: 10.1158/0008-5472.CAN-05-1177.
• [561] Lunasin, a novel seed peptide, sensitizes human breast cancer MDA-MB-231 cells to aspirin-arrested cell cycle and induced apoptosis. Chem Biol Interact. 2010 Jul 30;186(2):127-34. doi: 10.1016/j.cbi.2010.04.027. Epub 2010 May 21.
• [562] Hydroquinone Exposure Worsens Rheumatoid Arthritis through the Activation of the Aryl Hydrocarbon Receptor and Interleukin-17 Pathways. Antioxidants (Basel). 2021 Jun 7;10(6):929. doi: 10.3390/antiox10060929.
• [563] NADPH oxidase-produced superoxide mediates EGFR transactivation by c-Src in arsenic trioxide-stimulated human keratinocytes. Arch Toxicol. 2012 Jun;86(6):935-45. doi: 10.1007/s00204-012-0856-9. Epub 2012 Apr 25.
• [564] Activation of peroxisome proliferator-activated receptor gamma contributes to the survival of T lymphoma cells by affecting cellular metabolism. Am J Pathol. 2007 Feb;170(2):722-32. doi: 10.2353/ajpath.2007.060651.
• [565] 1,25-dihydroxyvitamin D3 stimulates activin A production to fine-tune osteoblast-induced mineralization. J Cell Physiol. 2013 Nov;228(11):2167-74. doi: 10.1002/jcp.24388.
• [566] Cannabidiol and Oxygen-Ozone Combination Induce Cytotoxicity in Human Pancreatic Ductal Adenocarcinoma Cell Lines. Cancers (Basel). 2020 Sep 27;12(10):2774. doi: 10.3390/cancers12102774.
• [567] Sulindac induces specific degradation of the HPV oncoprotein E7 and causes growth arrest and apoptosis in cervical carcinoma cells. Cancer Lett. 2007 Jan 8;245(1-2):103-11. doi: 10.1016/j.canlet.2005.12.034. Epub 2006 Feb 20.
• [568] CDK4/6 inhibition provides a potent adjunct to Her2-targeted therapies in preclinical breast cancer models. Genes Cancer. 2014 Jul;5(7-8):261-72. doi: 10.18632/genesandcancer.24.
• [569] TGF-1 signaling protects retinal ganglion cells from oxidative stress via modulation of the HO-1/Nrf2 pathway. Chem Biol Interact. 2020 Nov 1;331:109249. doi: 10.1016/j.cbi.2020.109249. Epub 2020 Sep 24.
• [570] 2-Chlorodeoxyadenosine alone and in combination with cyclophosphamide and mitoxantrone induce apoptosis in B chronic lymphocytic leukemia cells in vivo. Cancer Detect Prev. 2004;28(6):433-42. doi: 10.1016/j.cdp.2004.08.001.
• [571] Focal striatal dopamine may potentiate dyskinesias in parkinsonian monkeys. Exp Neurol. 2006 Feb;197(2):363-72. doi: 10.1016/j.expneurol.2005.10.022. Epub 2005 Dec 9.
• [572] Decarboxylases as hypothetical targets for actions of organophosphates: Molecular modeling for prediction of hidden and unexpected health threats. Food Chem Toxicol. 2022 Mar;161:112856. doi: 10.1016/j.fct.2022.112856. Epub 2022 Feb 11.
• [573] Nephrotoxicity induced by cisplatin is primarily due to the activation of the 5-hydroxytryptamine degradation system in proximal renal tubules. Chem Biol Interact. 2021 Nov 1;349:109662. doi: 10.1016/j.cbi.2021.109662. Epub 2021 Sep 21.
• [574] Darinaparsin: solid tumor hypoxic cytotoxin and radiosensitizer. Clin Cancer Res. 2012 Jun 15;18(12):3366-76.
• [575] Heme oxygenase-1 and interleukin-11 are overexpressed in stress-induced premature senescence of human WI-38 fibroblasts induced by tert-butylhydroperoxide and ethanol. Biogerontology. 2007 Aug;8(4):409-22. doi: 10.1007/s10522-007-9084-8. Epub 2007 Feb 13.
• [576] 14-3-3 regulation of and interaction with YAP1 in acquired gemcitabine resistance via promoting ribonucleotide reductase expression. Oncotarget. 2016 Apr 5;7(14):17726-36. doi: 10.18632/oncotarget.7394.
• [577] Nuclear and Mitochondrial DNA Methylation Patterns Induced by Valproic Acid in Human Hepatocytes. Chem Res Toxicol. 2017 Oct 16;30(10):1847-1854. doi: 10.1021/acs.chemrestox.7b00171. Epub 2017 Sep 13.
• [578] [Construction of subtracted cDNA library in human Jurkat T cell line induced by arsenic trioxide in vitro]. Zhonghua Yu Fang Yi Xue Za Zhi. 2003 Nov;37(6):403-7.
• [579] Nonenantioselectivity property of human deoxycytidine kinase explained by structures of the enzyme in complex with L- and D-nucleosides. J Med Chem. 2007 Jun 28;50(13):3004-14. doi: 10.1021/jm0700215. Epub 2007 May 27.
• [580] Pathophysiological roles of aldo-keto reductases (AKR1C1 and AKR1C3) in development of cisplatin resistance in human colon cancers. Chem Biol Interact. 2013 Feb 25;202(1-3):234-42.
• [581] Inhibition of PARP1 Increases IRF-dependent Gene Transcription in Jurkat Cells. Curr Med Sci. 2019 Jun;39(3):356-362. doi: 10.1007/s11596-019-2043-1. Epub 2019 Jun 17.
• [582] Complex genetic response of human cells to sublethal levels of pure nitric oxide. Cancer Res. 1998 Aug 1;58(15):3435-40.
• [583] Inflammation in methotrexate-induced pulmonary toxicity occurs via the p38 MAPK pathway. Toxicology. 2009 Feb 27;256(3):183-90. doi: 10.1016/j.tox.2008.11.016. Epub 2008 Nov 28.
• [584] A gene signature-based approach identifies thioridazine as an inhibitor of phosphatidylinositol-3'-kinase (PI3K)/AKT pathway in ovarian cancer cells. Gynecol Oncol. 2011 Jan;120(1):121-7. doi: 10.1016/j.ygyno.2010.10.003. Epub 2010 Oct 29.
• [585] Activation of the p38 MAPK/Akt/ERK1/2 signal pathways is required for the protein stabilization of CDC6 and cyclin D1 in low-dose arsenite-induced cell proliferation. J Cell Biochem. 2010 Dec 15;111(6):1546-55. doi: 10.1002/jcb.22886.
• [586] Vitamin D receptor as a master regulator of the c-MYC/MXD1 network. Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18827-32. doi: 10.1073/pnas.1210037109. Epub 2012 Oct 29.
• [587] Arsenic trioxide-mediated growth inhibition in MC/CAR myeloma cells via cell cycle arrest in association with induction of cyclin-dependent kinase inhibitor, p21, and apoptosis. Cancer Res. 2000 Jun 1;60(11):3065-71.
• [588] Delta9-tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulation. Cancer Res. 2006 Jul 1;66(13):6615-21. doi: 10.1158/0008-5472.CAN-05-4566.
• [589] Hydroquinone increases 5-hydroxymethylcytosine formation through ten eleven translocation 1 (TET1) 5-methylcytosine dioxygenase. J Biol Chem. 2013 Oct 4;288(40):28792-800. doi: 10.1074/jbc.M113.491365. Epub 2013 Aug 12.
• [590] Extracellular ATP drives breast cancer cell migration and metastasis via S100A4 production by cancer cells and fibroblasts. Cancer Lett. 2018 Aug 28;430:1-10. doi: 10.1016/j.canlet.2018.04.043. Epub 2018 May 5.
• [591] Inter-laboratory comparison of human renal proximal tubule (HK-2) transcriptome alterations due to Cyclosporine A exposure and medium exhaustion. Toxicol In Vitro. 2009 Apr;23(3):486-99.
• [592] Darinaparsin induces a unique cellular response and is active in an arsenic trioxide-resistant myeloma cell line. Mol Cancer Ther. 2009 May;8(5):1197-206.
• [593] Nucleophosmin in the pathogenesis of arsenic-related bladder carcinogenesis revealed by quantitative proteomics. Toxicol Appl Pharmacol. 2010 Jan 15;242(2):126-35. doi: 10.1016/j.taap.2009.09.016. Epub 2009 Oct 7.
• [594] Dexamethasone and the inflammatory response in explants of human omental adipose tissue. Mol Cell Endocrinol. 2010 Feb 5;315(1-2):292-8.
• [595] Association between SCN1A polymorphism and carbamazepine-resistant epilepsy. Br J Clin Pharmacol. 2008 Aug;66(2):304-7. doi: 10.1111/j.1365-2125.2008.03203.x. Epub 2008 Apr 11.
• [596] Inhibitory effects of cannabidiol on voltage-dependent sodium currents. J Biol Chem. 2018 Oct 26;293(43):16546-16558. doi: 10.1074/jbc.RA118.004929. Epub 2018 Sep 14.
• [597] Expression dynamics of pregnane X receptor-controlled genes in 3D primary human hepatocyte spheroids. Arch Toxicol. 2022 Jan;96(1):195-210. doi: 10.1007/s00204-021-03177-y. Epub 2021 Oct 23.
• [598] Induction of CCAAT/enhancer-binding protein-homologous protein by cigarette smoke through the superoxide anion-triggered PERK-eIF2 pathway. Toxicology. 2011 Sep 5;287(1-3):105-12. doi: 10.1016/j.tox.2011.06.005. Epub 2011 Jun 15.
• [599] Amiodarone sensitizes human glioma cells but not astrocytes to TRAIL-induced apoptosis via CHOP-mediated DR5 upregulation. Neuro Oncol. 2011 Mar;13(3):267-79. doi: 10.1093/neuonc/noq195. Epub 2011 Feb 3.
• [600] High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities. Arch Toxicol. 2017 Mar;91(3):1367-1383. doi: 10.1007/s00204-016-1781-0. Epub 2016 Jun 29.
• [601] Utilization of causal reasoning of hepatic gene expression in rats to identify molecular pathways of idiosyncratic drug-induced liver injury. Toxicol Sci. 2014 Jan;137(1):234-48. doi: 10.1093/toxsci/kft232. Epub 2013 Oct 17.
• [602] Gene expression profiling of breast cancer cells in response to gemcitabine: NF-kappaB pathway activation as a potential mechanism of resistance. Breast Cancer Res Treat. 2007 Apr;102(2):157-72.
• [603] BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile. J Biochem Mol Toxicol. 2019 May;33(5):e22286. doi: 10.1002/jbt.22286. Epub 2019 Jan 23.
• [604] Glucocorticoids induce G1 arrest of lymphoblastic cells through retinoblastoma protein Rb1 dephosphorylation in childhood acute lymphoblastic leukemia in vivo. Cancer Biol Ther. 2004 May;3(5):470-6. doi: 10.4161/cbt.3.5.838. Epub 2004 May 9.
• [605] Persistent and non-persistent changes in gene expression result from long-term estrogen exposure of MCF-7 breast cancer cells. J Steroid Biochem Mol Biol. 2011 Feb;123(3-5):140-50.
• [606] ZD1839 induces p15INK4b and causes G1 arrest by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway. Mol Cancer Ther. 2007 May;6(5):1579-87. doi: 10.1158/1535-7163.MCT-06-0814.
• [607] Constitutive gene expression predisposes morphogen-mediated cell fate responses of NT2/D1 and 27X-1 human embryonal carcinoma cells. Stem Cells. 2007 Mar;25(3):771-8. doi: 10.1634/stemcells.2006-0271. Epub 2006 Nov 30.
• [608] Arsenic trioxide inhibits P-glycoprotein expression in multidrug-resistant human leukemia K562/ADM cell line that overexpresses mdr-1 gene and enhances their chemotherapeutic sensitivity. Zhonghua Xue Ye Xue Za Zhi. 2003 Jan;24(1):28-31.
• [609] A novel mechanism for pergolide-induced neuroprotection: inhibition of NF-kappaB nuclear translocation. Biochem Pharmacol. 2004 May 1;67(9):1743-50. doi: 10.1016/j.bcp.2004.01.012.
• [610] Antitumor effects of aminobisphosphonates on renal cell carcinoma cell lines. J Urol. 2006 Nov;176(5):2255-61. doi: 10.1016/j.juro.2006.07.053.
• [611] Effect of menstrual cycle and hormonal treatment on ki-67 and bcl-2 expression and adenomyosis. Gynecol Endocrinol. 2005 Mar;20(3):127-31. doi: 10.1080/09513590400021086.
• [612] An in vitro study on anti-carcinogenic effect of remdesivir in human ovarian cancer cells via generation of reactive oxygen species. Hum Exp Toxicol. 2022 Jan-Dec;41:9603271221089257. doi: 10.1177/09603271221089257.
• [613] Mitophagy inhibits proliferation by decreasing cyclooxygenase-2 (COX-2) in arsenic trioxide-treated HepG2 cells. Environ Toxicol Pharmacol. 2016 Jul;45:212-21.
• [614] Thalidomide suppresses angiogenesis and immune evasion via lncRNA FGD5-AS1/miR-454-3p/ZEB1 axis-mediated VEGFA expression and PD-1/PD-L1 checkpoint in NSCLC. Chem Biol Interact. 2021 Nov 1;349:109652. doi: 10.1016/j.cbi.2021.109652. Epub 2021 Sep 11.
• [615] Folate deficiency in normal human fibroblasts leads to altered expression of genes primarily linked to cell signaling, the cytoskeleton and extracellular matrix. J Nutr Biochem. 2007 Aug;18(8):541-52. doi: 10.1016/j.jnutbio.2006.11.002. Epub 2007 Feb 22.
• [616] Induction of multidrug resistance proteins MRP1 and MRP3 and gamma-glutamylcysteine synthetase gene expression by nonsteroidal anti-inflammatory drugs in human colon cancer cells. Biochem Biophys Res Commun. 2002 Feb 8;290(5):1427-33. doi: 10.1006/bbrc.2002.6367.
• [617] Flavonoids increase the intracellular glutathione level by transactivation of the gamma-glutamylcysteine synthetase catalytical subunit promoter. Free Radic Biol Med. 2002 Mar 1;32(5):386-93. doi: 10.1016/s0891-5849(01)00812-7.
• [618] Glycidamide and cis-2-butene-1,4-dial (BDA) as potential carcinogens and promoters of liver cancer - An in vitro study. Food Chem Toxicol. 2022 Aug;166:113251. doi: 10.1016/j.fct.2022.113251. Epub 2022 Jun 21.
• [619] Gene expression signatures after ethanol exposure in differentiating embryoid bodies. Toxicol In Vitro. 2018 Feb;46:66-76.
• [620] Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21.
• [621] Synergistic interaction of lovastatin and paclitaxel in human cancer cells. Mol Cancer Ther. 2001 Dec;1(2):141-9.
• [622] High-throughput cell-based screening of 4910 known drugs and drug-like small molecules identifies disulfiram as an inhibitor of prostate cancer cell growth. Clin Cancer Res. 2009 Oct 1;15(19):6070-8.
• [623] Screening the ToxCast Phase 1, Phase 2, and e1k Chemical Libraries for Inhibitors of Iodothyronine Deiodinases. Toxicol Sci. 2019 Apr 1;168(2):430-442. doi: 10.1093/toxsci/kfy302.
• [624] Effects of all-trans and 9-cis retinoic acid on differentiating human neural stem cells in vitro. Toxicology. 2023 Mar 15;487:153461. doi: 10.1016/j.tox.2023.153461. Epub 2023 Feb 16.
• [625] Regulation of type 1 iodothyronine deiodinase in health and disease. Thyroid. 2005 Aug;15(8):835-40. doi: 10.1089/thy.2005.15.835.
• [626] Screening the ToxCast Phase 1 Chemical Library for Inhibition of Deiodinase Type 1 Activity. Toxicol Sci. 2018 Apr 1;162(2):570-581. doi: 10.1093/toxsci/kfx279.
• [627] Association of Arsenic Exposure with Whole Blood DNA Methylation: An Epigenome-Wide Study of Bangladeshi Adults. Environ Health Perspect. 2019 May;127(5):57011. doi: 10.1289/EHP3849. Epub 2019 May 28.
• [628] Ouabain impairs cell migration, and invasion and alters gene expression of human osteosarcoma U-2 OS cells. Environ Toxicol. 2017 Nov;32(11):2400-2413. doi: 10.1002/tox.22453. Epub 2017 Aug 10.
• [629] Sevoflurane-mediated activation of p38-mitogen-activated stresskinase is independent of apoptosis in Jurkat T-cells. Anesth Analg. 2008 Apr;106(4):1150-60, table of contents. doi: 10.1213/ane.0b013e3181683d37.
• [630] Epigallocatechin-3-gallate (EGCG) protects against chromate-induced toxicity in vitro. Toxicol Appl Pharmacol. 2012 Jan 15;258(2):166-75.
• [631] Comparison of transcriptome expression alterations by chronic exposure to low-dose bisphenol A in different subtypes of breast cancer cells. Toxicol Appl Pharmacol. 2019 Dec 15;385:114814. doi: 10.1016/j.taap.2019.114814. Epub 2019 Nov 9.
• [632] Systematic identification of arsenic-binding proteins reveals that hexokinase-2 is inhibited by arsenic. Proc Natl Acad Sci U S A. 2015 Dec 8;112(49):15084-9. doi: 10.1073/pnas.1521316112. Epub 2015 Nov 23.
• [633] Combination of imatinib and clotrimazole enhances cell growth inhibition in T47D breast cancer cells. Chem Biol Interact. 2015 May 25;233:147-56. doi: 10.1016/j.cbi.2015.03.028. Epub 2015 Apr 8.
• [634] Ivermectin accelerates autophagic death of glioma cells by inhibiting glycolysis through blocking GLUT4 mediated JAK/STAT signaling pathway activation. Environ Toxicol. 2022 Apr;37(4):754-764. doi: 10.1002/tox.23440. Epub 2021 Dec 14.
• [635] Endoplasmic reticulum stress impairs insulin signaling through mitochondrial damage in SH-SY5Y cells. Neurosignals. 2012;20(4):265-80.
• [636] Bisphenol A Exposure Changes the Transcriptomic and Proteomic Dynamics of Human Retinoblastoma Y79 Cells. Genes (Basel). 2021 Feb 11;12(2):264. doi: 10.3390/genes12020264.
• [637] Type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase (AKR1C3): role in breast cancer and inhibition by non-steroidal anti-inflammatory drug analogs. Chem Biol Interact. 2009 Mar 16;178(1-3):221-7.
• [638] Substrate specificity of human 3(20)alpha-hydroxysteroid dehydrogenase for neurosteroids and its inhibition by benzodiazepines. Biol Pharm Bull. 2002 Apr;25(4):441-5.
• [639] A new in vitro method for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells. Cutan Ocul Toxicol. 2010 Sep;29(3):171-92.
• [640] Activation of PPAR and inhibition of cell proliferation reduces key proteins associated with the basal subtype of bladder cancer in As3+-transformed UROtsa cells. PLoS One. 2020 Aug 21;15(8):e0237976. doi: 10.1371/journal.pone.0237976. eCollection 2020.
• [641] Analysis of the transcriptional regulation of cancer-related genes by aberrant DNA methylation of the cis-regulation sites in the promoter region during hepatocyte carcinogenesis caused by arsenic. Oncotarget. 2015 Aug 28;6(25):21493-506. doi: 10.18632/oncotarget.4085.
• [642] Regulation of antiprotease and antimicrobial protein secretion by airway submucosal gland serous cells. J Biol Chem. 2004 Sep 10;279(37):38854-60. doi: 10.1074/jbc.M407077200. Epub 2004 Jul 2.
• [643] DNA microarray analysis of changes in gene expression induced by 1,25-dihydroxyvitamin D3 in human promyelocytic leukemia HL-60 cells. Biomed Res. 2006 Jun;27(3):99-109. doi: 10.2220/biomedres.27.99.
• [644] Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons. PLoS One. 2009 Sep 23;4(9):e7155.
• [645] Gonadal steroids regulate GABAA receptor subunit mRNA expression in NT2-N neurons. Brain Res Mol Brain Res. 2005 Aug 18;138(2):105-15. doi: 10.1016/j.molbrainres.2004.10.047.
• [646] Dose- and time-dependent transcriptional response of Ishikawa cells exposed to genistein. Toxicol Sci. 2016 May;151(1):71-87.
• [647] BET bromodomain protein inhibition is a therapeutic option for medulloblastoma. Oncotarget. 2013 Nov;4(11):2080-95.
• [648] NOTCH signaling is activated in and contributes to resistance in enzalutamide-resistant prostate cancer cells. J Biol Chem. 2019 May 24;294(21):8543-8554. doi: 10.1074/jbc.RA118.006983. Epub 2019 Apr 2.
• [649] SGK1, a potential regulator of c-fms related breast cancer aggressiveness. Clin Exp Metastasis. 2004;21(6):477-83.
• [650] Species-specific differences in the inhibition of human and zebrafish 11beta-hydroxysteroid dehydrogenase 2 by thiram and organotins. Toxicology. 2012 Nov 15;301(1-3):72-8.
• [651] Antiepileptic drugs are endocrine disruptors for the human fetal testis ex vivo. Toxicol Sci. 2023 Sep 28;195(2):169-183. doi: 10.1093/toxsci/kfad076.
• [652] Inhibition of 11-hydroxysteroid dehydrogenase 2 by the fungicides itraconazole and posaconazole. Biochem Pharmacol. 2017 Apr 15;130:93-103. doi: 10.1016/j.bcp.2017.01.010. Epub 2017 Jan 25.
• [653] cAMP/PKA/EGR1 signaling mediates the molecular mechanism of ethanol-induced inhibition of placental 11beta-HSD2 expression. Toxicol Appl Pharmacol. 2018 Aug 1;352:77-86.
• [654] The anabolic androgenic steroid fluoxymesterone inhibits 11beta-hydroxysteroid dehydrogenase 2-dependent glucocorticoid inactivation. Toxicol Sci. 2012 Apr;126(2):353-61.
• [655] Riboflavin depletion impairs cell proliferation in adult human duodenum: identification of potential effectors. Dig Dis Sci. 2011 Apr;56(4):1007-19. doi: 10.1007/s10620-010-1374-3. Epub 2010 Sep 17.
• [656] Early Transcriptomic Changes upon Thalidomide Exposure Influence the Later Neuronal Development in Human Embryonic Stem Cell-Derived Spheres. Int J Mol Sci. 2020 Aug 3;21(15):5564. doi: 10.3390/ijms21155564.
• [657] Hematopoietically expressed homeobox is a target gene of farnesoid X receptor in chenodeoxycholic acid-induced liver hypertrophy. Hepatology. 2009 Mar;49(3):979-88. doi: 10.1002/hep.22712.
• [658] Self-assembled 3D spheroids and hollow-fibre bioreactors improve MSC-derived hepatocyte-like cell maturation in vitro. Arch Toxicol. 2017 Apr;91(4):1815-1832.
• [659] Progestin effects on expression of AKR1C1-AKR1C3, SRD5A1 and PGR in the Z-12 endometriotic epithelial cell line. Chem Biol Interact. 2013 Feb 25;202(1-3):218-25.
• [660] Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase. Cancer Res. 1999 Feb 1;59(3):607-14.
• [661] Initro inhibition of AKR1Cs by sulphonylureas and the structural basis. Chem Biol Interact. 2015 Oct 5;240:310-5.
• [662] Analysis of telomerase activity and RNA expression in a patient with acute promyelocytic leukemia treated with all-trans retinoic acid. Pediatr Blood Cancer. 2006 Apr;46(4):506-11. doi: 10.1002/pbc.20392.
• [663] Anthelmintic Niclosamide Disrupts the Interplay of p65 and FOXM1/-catenin and Eradicates Leukemia Stem Cells in Chronic Myelogenous Leukemia. Clin Cancer Res. 2017 Feb 1;23(3):789-803. doi: 10.1158/1078-0432.CCR-16-0226. Epub 2016 Aug 4.
• [664] Advantageous use of HepaRG cells for the screening and mechanistic study of drug-induced steatosis. Toxicol Appl Pharmacol. 2016 Jul 1;302:1-9. doi: 10.1016/j.taap.2016.04.007. Epub 2016 Apr 16.
• [665] In vitro assessment of drug-induced liver steatosis based on human dermal stem cell-derived hepatic cells. Arch Toxicol. 2016 Mar;90(3):677-89. doi: 10.1007/s00204-015-1483-z. Epub 2015 Feb 26.
• [666] Replacement per- and polyfluoroalkyl substances (PFAS) are potent modulators of lipogenic and drug metabolizing gene expression signatures in primary human hepatocytes. Toxicol Appl Pharmacol. 2022 May 1;442:115991. doi: 10.1016/j.taap.2022.115991. Epub 2022 Mar 23.
• [667] Comprehensive transcriptome profiling of BET inhibitor-treated HepG2 cells. PLoS One. 2022 Apr 29;17(4):e0266966. doi: 10.1371/journal.pone.0266966. eCollection 2022.
• [668] [Effects of Arsenic Trioxide on Cdc20 and Mad2 in Acute Myeloid Leukemia HL-60 Cell Line]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2018 Jun;26(3):710-715. doi: 10.7534/j.issn.1009-2137.2018.03.013.
• [669] Heterozygosity for a point mutation in an invariant splice donor site of dihydropyrimidine dehydrogenase and severe 5-fluorouracil related toxicity. Eur J Cancer. 1997 Nov;33(13):2258-64. doi: 10.1016/s0959-8049(97)00261-x.
• [670] DPD is a molecular determinant of capecitabine efficacy in colorectal cancer. Int J Oncol. 2007 Aug;31(2):413-8.
• [671] Dihydropyrimidine dehydrogenases and cytidine-deaminase gene polymorphisms as outcome predictors in resected gastric cancer patients treated with fluoropyrimidine adjuvant chemotherapy. J Surg Oncol. 2008 Aug 1;98(2):130-4.
• [672] Gene expression profile induced by arsenic trioxide in chronic lymphocytic leukemia cells reveals a central role for heme oxygenase-1 in apoptosis and regulation of matrix metalloproteinase-9. Oncotarget. 2016 Dec 13;7(50):83359-83377.
• [673] Troglitazone induces p27Kip1-associated cell-cycle arrest through down-regulating Skp2 in human hepatoma cells. Hepatology. 2003 May;37(5):1086-96. doi: 10.1053/jhep.2003.50186.
• [674] Computational discovery of niclosamide ethanolamine, a repurposed drug candidate that reduces growth of hepatocellular carcinoma cells initro and in mice by inhibiting cell division cycle 37 signaling. Gastroenterology. 2017 Jun;152(8):2022-2036.
• [675] Antidepressant drug sertraline modulates AMPK-MTOR signaling-mediated autophagy via targeting mitochondrial VDAC1 protein. Autophagy. 2021 Oct;17(10):2783-2799. doi: 10.1080/15548627.2020.1841953. Epub 2020 Nov 9.
• [676] Autophagy Inhibition Overcomes the Antagonistic Effect Between Gefitinib and Cisplatin in Epidermal Growth Factor Receptor Mutant Non--Small-Cell Lung Cancer Cells. Clin Lung Cancer. 2015 Sep;16(5):e55-66. doi: 10.1016/j.cllc.2015.03.006. Epub 2015 Apr 2.
• [677] Harnessing autophagy to overcome mitogen-activated protein kinase kinase inhibitor-induced resistance in metastatic melanoma. Br J Dermatol. 2019 Feb;180(2):346-356. doi: 10.1111/bjd.17333. Epub 2018 Nov 25.
• [678] Delta9-tetrahydrocannabinol inhibits cytotrophoblast cell proliferation and modulates gene transcription. Mol Hum Reprod. 2006 May;12(5):321-33. doi: 10.1093/molehr/gal036. Epub 2006 Apr 5.
• [679] Transcriptome profile analysis of saturated aliphatic aldehydes reveals carbon number-specific molecules involved in pulmonary toxicity. Chem Res Toxicol. 2014 Aug 18;27(8):1362-70.
• [680] Cholesterol increases protein levels of the E3 ligase MARCH6 and thereby stimulates protein degradation. J Biol Chem. 2019 Feb 15;294(7):2436-2448. doi: 10.1074/jbc.RA118.005069. Epub 2018 Dec 13.
• [681] Human prostaglandin reductase 1 (PGR1): Substrate specificity, inhibitor analysis and site-directed mutagenesis. Chem Biol Interact. 2015 Jun 5;234:105-13.
• [682] High-throughput ectopic expression screen for tamoxifen resistance identifies an atypical kinase that blocks autophagy. Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2058-63.
• [683] Effects of paclitaxel on proliferation and apoptosis in human acute myeloid leukemia HL-60 cells. Acta Pharmacol Sin. 2004 Mar;25(3):378-84.
• [684] Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. Genome Res. 2012 Nov;22(11):2153-62.
• [685] Differential responses to retinoic acid and endocrine disruptor compounds of subpopulations within human embryonic stem cell lines. Differentiation. 2012 Nov;84(4):330-43. doi: 10.1016/j.diff.2012.07.006. Epub 2012 Aug 18.
• [686] Interaction of EZH2 and P65 is involved in the arsenic trioxide-induced anti-angiogenesis in human triple-negative breast cancer cells. Cell Biol Toxicol. 2019 Aug;35(4):361-371. doi: 10.1007/s10565-018-09458-0. Epub 2019 Jan 5.
• [687] In vitro hydroquinone-induced instauration of histone bivalent mark on human retroelements (LINE-1) in HL60 cells. Toxicol In Vitro. 2017 Apr;40:1-10. doi: 10.1016/j.tiv.2016.12.007. Epub 2016 Dec 13.
• [688] Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors. Arch Toxicol. 2021 Feb;95(2):591-615. doi: 10.1007/s00204-020-02970-5. Epub 2021 Jan 29.
• [689] Different pathways are involved in arsenic-trioxide-induced cell proliferation and growth inhibition in human keratinocytes. Skin Pharmacol Physiol. 2010;23(2):68-78. doi: 10.1159/000265677. Epub 2009 Dec 14.
• [690] Drinking-water arsenic exposure modulates gene expression in human lymphocytes from a U.S. population. Environ Health Perspect. 2008 Apr;116(4):524-31. doi: 10.1289/ehp.10861.
• [691] Effect of prenatal arsenic exposure on DNA methylation and leukocyte subpopulations in cord blood. Epigenetics. 2014 May;9(5):774-82. doi: 10.4161/epi.28153. Epub 2014 Feb 13.
• [692] A trichostatin A expression signature identified by TempO-Seq targeted whole transcriptome profiling. PLoS One. 2017 May 25;12(5):e0178302. doi: 10.1371/journal.pone.0178302. eCollection 2017.
• [693] Epidermal growth factor receptor signalling in human breast cancer cells operates parallel to estrogen receptor alpha signalling and results in tamoxifen insensitive proliferation. BMC Cancer. 2014 Apr 23;14:283.
• [694] Mutant p53 reactivation by PRIMA-1MET induces multiple signaling pathways converging on apoptosis. Oncogene. 2010 Mar 4;29(9):1329-38. doi: 10.1038/onc.2009.425. Epub 2009 Nov 30.
• [695] Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies. J Biol Chem. 2019 Oct 18;294(42):15218-15234. doi: 10.1074/jbc.RA119.009147. Epub 2019 Jul 8.
• [696] Phenethyl isothiocyanate alters the gene expression and the levels of protein associated with cell cycle regulation in human glioblastoma GBM 8401 cells. Environ Toxicol. 2017 Jan;32(1):176-187.
• [697] RNA sequence analysis of inducible pluripotent stem cell-derived cardiomyocytes reveals altered expression of DNA damage and cell cycle genes in response to doxorubicin. Toxicol Appl Pharmacol. 2018 Oct 1;356:44-53.
• [698] Gene expression in endometrial cancer cells (Ishikawa) after short time high dose exposure to progesterone. Steroids. 2008 Jan;73(1):116-28.
• [699] DNA methylation inhibits p53-mediated survivin repression. Oncogene. 2009 May 14;28(19):2046-50. doi: 10.1038/onc.2009.62. Epub 2009 Apr 13.
• [700] The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells. Leukemia. 2009 Jun;23(6):1019-28.
• [701] Peroxisome proliferator activated receptor gamma (PPAR-gama) ligand pioglitazone regulated gene networks in term human primary trophoblast cells. Reprod Toxicol. 2018 Oct;81:99-107.
• [702] Bisphenolic compounds alter gene expression in MCF-7 cells through interaction with estrogen receptor . Toxicol Appl Pharmacol. 2020 Jul 15;399:115030. doi: 10.1016/j.taap.2020.115030. Epub 2020 May 6.
• [703] PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells. J Exp Med. 2006 Oct 2;203(10):2351-62.
• [704] Pregnancy exposure to synthetic phenols and placental DNA methylation - An epigenome-wide association study in male infants from the EDEN cohort. Environ Pollut. 2021 Dec 1;290:118024. doi: 10.1016/j.envpol.2021.118024. Epub 2021 Aug 21.
• [705] Combination of arsenic trioxide and Dasatinib: a new strategy to treat Philadelphia chromosome-positive acute lymphoblastic leukaemia. J Cell Mol Med. 2018 Mar;22(3):1614-1626.
• [706] Comparative proteomics reveals concordant and discordant biochemical effects of caffeine versus epigallocatechin-3-gallate in human endothelial cells. Toxicol Appl Pharmacol. 2019 Sep 1;378:114621. doi: 10.1016/j.taap.2019.114621. Epub 2019 Jun 10.
• [707] Vitamin D3 transactivates the zinc and manganese transporter SLC30A10 via the Vitamin D receptor. J Steroid Biochem Mol Biol. 2016 Oct;163:77-87.
• [708] Integrated transcriptomic and metabolomic analyses to characterize the anti-cancer effects of (-)-epigallocatechin-3-gallate in human colon cancer cells. Toxicol Appl Pharmacol. 2020 Aug 15;401:115100. doi: 10.1016/j.taap.2020.115100. Epub 2020 Jun 6.
• [709] Novel ATP-competitive Akt inhibitor afuresertib suppresses the proliferation of malignant pleural mesothelioma cells. Cancer Med. 2017 Nov;6(11):2646-2659. doi: 10.1002/cam4.1179. Epub 2017 Sep 27.
• [710] Cystathionine metabolic enzymes play a role in the inflammation resolution of human keratinocytes in response to sub-cytotoxic formaldehyde exposure. Toxicol Appl Pharmacol. 2016 Nov 1;310:185-194.
• [711] Research resource: STR DNA profile and gene expression comparisons of human BG-1 cells and a BG-1/MCF-7 clonal variant. Mol Endocrinol. 2014 Dec;28(12):2072-81.
• [712] Clarifying off-target effects for torcetrapib using network pharmacology and reverse docking approach. BMC Syst Biol. 2012 Dec 10;6:152.
• [713] Identification of novel low-dose bisphenol a targets in human foreskin fibroblast cells derived from hypospadias patients. PLoS One. 2012;7(5):e36711. doi: 10.1371/journal.pone.0036711. Epub 2012 May 4.
• [714] ON 01910.Na is selectively cytotoxic for chronic lymphocytic leukemia cells through a dual mechanism of action involving PI3K/AKT inhibition and induction of oxidative stress. Clin Cancer Res. 2012 Apr 1;18(7):1979-91. doi: 10.1158/1078-0432.CCR-11-2113. Epub 2012 Feb 20.
• [715] Propofol suppresses proliferation, migration, invasion, and tumor growth of liver cancer cells via suppressing cancer susceptibility candidate 9/phosphatase and tensin homolog/AKT serine/threonine kinase/mechanistic target of rapamycin kinase axis. Hum Exp Toxicol. 2022 Jan-Dec;41:9603271211065972. doi: 10.1177/09603271211065972.
• [716] Toxicoproteomics reveals an effect of clozapine on autophagy in human liver spheroids. Toxicol Mech Methods. 2023 Jun;33(5):401-410. doi: 10.1080/15376516.2022.2156005. Epub 2022 Dec 19.
• [717] Cardiac toxicity from ethanol exposure in human-induced pluripotent stem cell-derived cardiomyocytes. Toxicol Sci. 2019 May 1;169(1):280-292.
• [718] Preferential induction of the AhR gene battery in HepaRG cells after a single or repeated exposure to heterocyclic aromatic amines. Toxicol Appl Pharmacol. 2010 Nov 15;249(1):91-100.
• [719] Estrogenic GPR30 signalling induces proliferation and migration of breast cancer cells through CTGF. EMBO J. 2009 Mar 4;28(5):523-32.
• [720] Cordycepin inhibits the proliferation and progression of NPC by targeting the MAPK/ERK and -catenin pathways. Oncol Lett. 2022 Jan;23(1):20. doi: 10.3892/ol.2021.13138. Epub 2021 Nov 16.
• [721] Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma. Oncotarget. 2014 May 15;5(9):2355-71.
• [722] Arsenic trioxide promotes ERK1/2-mediated phosphorylation and degradation of BIM(EL) to attenuate apoptosis in BEAS-2B cells. Chem Biol Interact. 2023 Jan 5;369:110304. doi: 10.1016/j.cbi.2022.110304. Epub 2022 Dec 10.
• [723] Pterostilbene attenuates RIPK3-dependent hepatocyte necroptosis in alcoholic liver disease via SIRT2-mediated NFATc4 deacetylation. Toxicology. 2021 Sep;461:152923. doi: 10.1016/j.tox.2021.152923. Epub 2021 Aug 30.
• [724] Low-dose Bisphenol A exposure alters the functionality and cellular environment in a human cardiomyocyte model. Environ Pollut. 2023 Oct 15;335:122359. doi: 10.1016/j.envpol.2023.122359. Epub 2023 Aug 9.
• [725] Gene expression changes in primary human nasal epithelial cells exposed to formaldehyde in vitro. Toxicol Lett. 2010 Oct 5;198(2):289-95.
• [726] Toxicogenomics of kojic acid on gene expression profiling of a375 human malignant melanoma cells. Biol Pharm Bull. 2006 Apr;29(4):655-69.
• [727] Oxidative stress-induced TET1 upregulation mediates active DNA demethylation in human gastric epithelial cells. J Toxicol Sci. 2023;48(5):273-283. doi: 10.2131/jts.48.273.
• [728] Effects of Exposure to Acetaminophen and Ibuprofen on Fetal Germ Cell Development in Both Sexes in Rodent and Human Using Multiple Experimental Systems. Environ Health Perspect. 2018 Apr 16;126(4):047006. doi: 10.1289/EHP2307.
• [729] Gene expression profile analysis of gallic acid-induced cell death process. Sci Rep. 2021 Aug 18;11(1):16743. doi: 10.1038/s41598-021-96174-1.
• [730] Characterisation of cisplatin-induced transcriptomics responses in primary mouse hepatocytes, HepG2 cells and mouse embryonic stem cells shows conservation of regulating transcription factor networks. Mutagenesis. 2014 Jan;29(1):17-26.
• [731] Tumor necrosis factor-alpha-induced protein 3 as a putative regulator of nuclear factor-kappaB-mediated resistance to O6-alkylating agents in human glioblastomas. J Clin Oncol. 2006 Jan 10;24(2):274-87. doi: 10.1200/JCO.2005.02.9405. Epub 2005 Dec 19.
• [732] Evaluation of developmental toxicity using undifferentiated human embryonic stem cells. J Appl Toxicol. 2015 Feb;35(2):205-18.
• [733] Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(a)pyrene. Toxicol Sci. 2010 Apr;114(2):247-59.
• [734] High expression of the Pi-transporter SLC20A1/Pit1 in calcific aortic valve disease promotes mineralization through regulation of Akt-1. PLoS One. 2013;8(1):e53393. doi: 10.1371/journal.pone.0053393. Epub 2013 Jan 4.
• [735] Evidence for a role of claudin 2 as a proximal tubular stress responsive paracellular water channel. Toxicol Appl Pharmacol. 2014 Sep 1;279(2):163-72.
• [736] Real-time monitoring of cisplatin-induced cell death. PLoS One. 2011;6(5):e19714. doi: 10.1371/journal.pone.0019714. Epub 2011 May 16.
• [737] Peripheral blood expression of nuclear factor-kappab-regulated genes is associated with rheumatoid arthritis disease activity and responds differentially to anti-tumor necrosis factor-alpha versus methotrexate. J Rheumatol. 2007 Sep;34(9):1817-22. Epub 2007 Aug 1.
• [738] Nitric oxide suppresses tumor cell migration through N-Myc downstream-regulated gene-1 (NDRG1) expression: role of chelatable iron. J Biol Chem. 2011 Dec 2;286(48):41413-41424. doi: 10.1074/jbc.M111.287052. Epub 2011 Oct 5.
• [739] Methotrexate normalizes up-regulated folate pathway genes in rheumatoid arthritis. Arthritis Rheum. 2013 Nov;65(11):2791-802.
• [740] The reduced folate carrier (RFC) is cytotoxic to cells under conditions of severe folate deprivationRFC as a double edged sword in folate homeostasis. J Biol Chem. 2008 Jul 25;283(30):20687-95.
• [741] Functional defect caused by the 4544G>A SNP in ABCC2: potential impact for drug cellular disposition. Pharmacogenet Genomics. 2011 Dec;21(12):884-93. doi: 10.1097/FPC.0b013e32834d672b.
• [742] Role of multidrug resistance protein 2 (MRP2, ABCC2) in alkylating agent detoxification: MRP2 potentiates glutathione S-transferase A1-1-mediated resistance to chlorambucil cytotoxicity. J Pharmacol Exp Ther. 2004 Jan;308(1):260-7. doi: 10.1124/jpet.103.057729. Epub 2003 Oct 20.
• [743] MRP2 (ABCC2) transports taxanes and confers paclitaxel resistance and both processes are stimulated by probenecid. Int J Cancer. 2005 Sep 20;116(5):824-9. doi: 10.1002/ijc.21013.
• [744] Association of genetic polymorphisms in SLCO1B3 and ABCC2 with docetaxel-induced leukopenia. Cancer Sci. 2008 May;99(5):967-72.
• [745] Potency of individual bile acids to regulate bile acid synthesis and transport genes in primary human hepatocyte cultures. Toxicol Sci. 2014 Oct;141(2):538-46. doi: 10.1093/toxsci/kfu151. Epub 2014 Jul 23.
• [746] Co-encapsulation of chrysophsin-1 and epirubicin in PEGylated liposomes circumvents multidrug resistance in HeLa cells. Chem Biol Interact. 2015 Dec 5;242:13-23. doi: 10.1016/j.cbi.2015.08.023. Epub 2015 Sep 1.
• [747] Evaluation of drug transporters' significance for multidrug resistance in head and neck squamous cell carcinoma. Head Neck. 2011 Jul;33(7):959-68. doi: 10.1002/hed.21559. Epub 2010 Aug 24.
• [748] Histamine H4 receptor agonists have more activities than H4 agonism in antigen-specific human T-cell responses. Immunology. 2007 Jun;121(2):266-75. doi: 10.1111/j.1365-2567.2007.02574.x. Epub 2007 Mar 7.
• [749] Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures. Arch Toxicol. 2018 Jun;92(6):1939-1952.
• [750] Gene expression profile of the nucleus accumbens of human cocaine abusers: evidence for dysregulation of myelin. J Neurochem. 2004 Mar;88(5):1211-9. doi: 10.1046/j.1471-4159.2003.02247.x.
• [751] Benzo[a]pyrene-induced changes in microRNA-mRNA networks. Chem Res Toxicol. 2012 Apr 16;25(4):838-49.
• [752] Oral contraceptives, thrombosis and haemostasis. Eur J Obstet Gynecol Reprod Biol. 2001 Apr;95(2):193-7. doi: 10.1016/s0301-2115(00)00489-9.
• [753] Differential effects of omega-3 and omega-6 Fatty acids on gene expression in breast cancer cells. Breast Cancer Res Treat. 2007 Jan;101(1):7-16. doi: 10.1007/s10549-006-9269-x. Epub 2006 Jul 6.
• [754] Decrements in the thrombin activatable fibrinolysis inhibitor (TAFI) levels in association with orlistat treatment in obesity. Clin Appl Thromb Hemost. 2006 Jul;12(3):364-8. doi: 10.1177/1076029606291403.
• [755] Effect of mood stabilizers on gene expression in lymphoblastoid cells. J Neural Transm (Vienna). 2010 Feb;117(2):155-64.
• [756] Cutaneous expression of cytochrome P450 CYP2S1: individuality in regulation by therapeutic agents for psoriasis and other skin diseases. Lancet. 2003 Apr 19;361(9366):1336-43.
• [757] CYP2S1 is negatively regulated by corticosteroids in human cell lines. Toxicol Lett. 2012 Feb 25;209(1):30-4.
• [758] Oxidative stress modulates KLF6Full and its splice variants. Alcohol Clin Exp Res. 2012 Nov;36(11):1851-62. doi: 10.1111/j.1530-0277.2012.01798.x. Epub 2012 Apr 6.
• [759] DNA double-strand breaks and Aurora B mislocalization induced by exposure of early mitotic cells to H(2)O(2) appear to increase chromatin bridges and resultant cytokinesis failure. Free Radic Biol Med. 2017 Jul;108:129-145. doi: 10.1016/j.freeradbiomed.2017.03.025. Epub 2017 Mar 24.
• [760] Biological specificity of CDK4/6 inhibitors: dose response relationship, in vivo signaling, and composite response signature. Oncotarget. 2017 Jul 4;8(27):43678-43691. doi: 10.18632/oncotarget.18435.
• [761] Expression of NAG-1, a transforming growth factor-beta superfamily member, by troglitazone requires the early growth response gene EGR-1. J Biol Chem. 2004 Feb 20;279(8):6883-92. doi: 10.1074/jbc.M305295200. Epub 2003 Dec 8.
• [762] Growth differentiation factor 15 production is necessary for normal erythroid differentiation and is increased in refractory anaemia with ring-sideroblasts. Br J Haematol. 2009 Jan;144(2):251-62. doi: 10.1111/j.1365-2141.2008.07441.x. Epub 2008 Nov 19.
• [763] Patterns of gene expressions induced by arsenic trioxide in cultured human fibroblasts. Toxicol Lett. 2003 Jul 20;143(2):155-62. doi: 10.1016/s0378-4274(03)00171-1.
• [764] Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Pharmacogenomics J. 2014 Feb;14(1):35-40. doi: 10.1038/tpj.2013.3. Epub 2013 Feb 12.
• [765] Drug-induced activation of SREBP-controlled lipogenic gene expression in CNS-related cell lines: marked differences between various antipsychotic drugs. BMC Neurosci. 2006 Oct 20;7:69.
• [766] Marked regression of liver metastasis by combined therapy of ultrasound-mediated NF kappaB-decoy transfer and transportal injection of paclitaxel, in mouse. Int J Cancer. 2008 Apr 1;122(7):1645-56. doi: 10.1002/ijc.23280.
• [767] Folic acid inhibits nasopharyngeal cancer cell proliferation and invasion via activation of FR/ERK1/2/TSLC1 pathway. Biosci Rep. 2017 Dec 5;37(6):BSR20170772. doi: 10.1042/BSR20170772. Print 2017 Dec 22.
• [768] Downregulation of TSLC1 and DAL-1 expression occurs frequently in breast cancer. Breast Cancer Res Treat. 2007 Jul;103(3):283-91. doi: 10.1007/s10549-006-9377-7. Epub 2007 Jan 27.
• [769] Mapping the dynamics of Nrf2 antioxidant and NFB inflammatory responses by soft electrophilic chemicals in human liver cells defines the transition from adaptive to adverse responses. Toxicol In Vitro. 2022 Oct;84:105419. doi: 10.1016/j.tiv.2022.105419. Epub 2022 Jun 17.
• [770] Successful validation of genomic biomarkers for human immunotoxicity in Jurkat T cells in vitro. J Appl Toxicol. 2015 Jul;35(7):831-41.
• [771] Molecular characterization of a toxicological tipping point during human stem cell differentiation. Reprod Toxicol. 2020 Jan;91:1-13. doi: 10.1016/j.reprotox.2019.10.001. Epub 2019 Oct 7.
• [772] Dolutegravir Impairs Stem Cell-Based 3D Morphogenesis Models in a Manner Dependent on Dose and Timing of Exposure: An Implication for Its Developmental Toxicity. Toxicol Sci. 2021 Nov 24;184(2):191-203. doi: 10.1093/toxsci/kfab112.
• [773] Chronic ethanol exposure increases goosecoid (GSC) expression in human embryonic carcinoma cell differentiation. J Appl Toxicol. 2014 Jan;34(1):66-75.
• [774] Gene regulation of CYP4F11 in human keratinocyte HaCaT cells. Drug Metab Dispos. 2010 Jan;38(1):100-7. doi: 10.1124/dmd.109.029025.
• [775] CYP4F2 repression and a modified alpha-tocopherol (vitamin E) metabolism are two independent consequences of ethanol toxicity in human hepatocytes. Toxicol In Vitro. 2017 Apr;40:124-133.
• [776] Role of oxidative stress in the induction of metallothionein-2A and heme oxygenase-1 gene expression by the antineoplastic agent gallium nitrate in human lymphoma cells. Free Radic Biol Med. 2008 Sep 15;45(6):763-72.
• [777] The NRF2-mediated oxidative stress response pathway is associated with tumor cell resistance to arsenic trioxide across the NCI-60 panel. BMC Med Genomics. 2010 Aug 13;3:37. doi: 10.1186/1755-8794-3-37.
• [778] Ouabain, a cardiac glycoside, inhibits the Fanconi anemia/BRCA pathway activated by DNA interstrand cross-linking agents. PLoS One. 2013 Oct 4;8(10):e75905. doi: 10.1371/journal.pone.0075905. eCollection 2013.
• [779] Arsenic-induced sumoylation of Mus81 is involved in regulating genomic stability. Cell Cycle. 2017 Apr 18;16(8):802-811. doi: 10.1080/15384101.2017.1302628. Epub 2017 Mar 20.
• [780] The low-toxicity 9-cis UAB30 novel retinoid down-regulates the DNA methyltransferases and has anti-telomerase activity in human breast cancer cells. Int J Oncol. 2007 Mar;30(3):641-50.
• [781] [Arsenic trioxide induced p15INK4B gene expression in myelodysplastic syndrome cell line MUTZ-1]. Zhonghua Xue Ye Xue Za Zhi. 2002 Dec;23(12):638-41.
• [782] Hypomethylation mediated by decreased DNMTs involves in the activation of proto-oncogene MPL in TK6 cells treated with hydroquinone. Toxicol Lett. 2012 Mar 25;209(3):239-45. doi: 10.1016/j.toxlet.2011.12.020. Epub 2012 Jan 8.
• [783] Alcohol triggered bile acid disequilibrium by suppressing BSEP to sustain hepatocellular carcinoma progression. Chem Biol Interact. 2022 Apr 1;356:109847. doi: 10.1016/j.cbi.2022.109847. Epub 2022 Feb 9.
• [784] Effect of the Catechol-O-Methyltransferase Inhibitors Tolcapone and Entacapone on Fatty Acid Metabolism in HepaRG Cells. Toxicol Sci. 2018 Aug 1;164(2):477-488.
• [785] Oestrogenic potencies of Zeranol, oestradiol, diethylstilboestrol, Bisphenol-A and genistein: implications for exposure assessment of potential endocrine disrupters. Hum Reprod. 2001 May;16(5):1037-45.
• [786] Quantitative proteomics and transcriptomics addressing the estrogen receptor subtype-mediated effects in T47D breast cancer cells exposed to the phytoestrogen genistein. Mol Cell Proteomics. 2011 Jan;10(1):M110.002170.
• [787] Gene expression profile of human lymphoid CEM cells sensitive and resistant to glucocorticoid-evoked apoptosis. Genomics. 2003 Jun;81(6):543-55.
• [788] Arsenic trioxide inhibits Hedgehog, Notch and stem cell properties in glioblastoma neurospheres. Acta Neuropathol Commun. 2014 Mar 31;2:31. doi: 10.1186/2051-5960-2-31.
• [789] Mechanism of cisplatin proximal tubule toxicity revealed by integrating transcriptomics, proteomics, metabolomics and biokinetics. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):117-27.
• [790] Cytotoxic Effects of Cannabinoids on Human HT-29 Colorectal Adenocarcinoma Cells: Different Mechanisms of THC, CBD, and CB83. Int J Mol Sci. 2020 Aug 1;21(15):5533. doi: 10.3390/ijms21155533.
• [791] Comparison of characteristics of peroxide-conditioned immortal human lens-epithelial cell lines with their murine counterparts. Exp Eye Res. 2004 Sep;79(3):411-7.
• [792] Quercetin modulates Nrf2 and glutathione-related defenses in HepG2 cells: Involvement of p38. Chem Biol Interact. 2012 Jan 25;195(2):154-64.
• [793] Glutathione depletion in antioxidant defense of differentiated NT2-LHON cybrids. Neurobiol Dis. 2007 Mar;25(3):536-44.
• [794] An approach to elucidate potential mechanism of renal toxicity of arsenic trioxide. Exp Hematol. 2007 Feb;35(2):252-62.
• [795] Down-regulation of Rap1GAP via promoter hypermethylation promotes melanoma cell proliferation, survival, and migration. Cancer Res. 2009 Jan 15;69(2):449-57. doi: 10.1158/0008-5472.CAN-08-2399.
• [796] Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue. Arch Toxicol. 2020 Dec;94(12):4037-4041. doi: 10.1007/s00204-020-02869-1. Epub 2020 Aug 17.
• [797] Indomethacin and juglone inhibit inflammatory molecules to induce apoptosis in colon cancer cells. J Biochem Mol Toxicol. 2020 Feb;34(2):e22433. doi: 10.1002/jbt.22433. Epub 2020 Jan 9.
• [798] A cell impedance-based real-time in vitro assay to assess the toxicity of amphotericin B formulations. Toxicol Appl Pharmacol. 2017 Nov 1;334:18-23. doi: 10.1016/j.taap.2017.08.017. Epub 2017 Sep 1.
• [799] CBD Promotes Oral Ulcer Healing via Inhibiting CMPK2-Mediated Inflammasome. J Dent Res. 2022 Feb;101(2):206-215. doi: 10.1177/00220345211024528. Epub 2021 Jul 16.
• [800] Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
• [801] Anti-inflammatory effects of the GABA(B) receptor agonist baclofen in allergic contact dermatitis. Exp Dermatol. 2010 Jul 1;19(7):661-6. doi: 10.1111/j.1600-0625.2010.01076.x. Epub 2010 Feb 25.
• [802] Frankincense myrrh attenuates hepatocellular carcinoma by regulating tumor blood vessel development through multiple epidermal growth factor receptor-mediated signaling pathways. World J Gastrointest Oncol. 2022 Feb 15;14(2):450-477. doi: 10.4251/wjgo.v14.i2.450.
• [803] Sulfasalazine unveils a contact-independent HSV-TK/ganciclovir gene therapy bystander effect in malignant gliomas. Int J Oncol. 2007 Jan;30(1):283-90.
• [804] Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction. J Toxicol Sci. 2020;45(11):673-680. doi: 10.2131/jts.45.673.
• [805] Profiling the immunotoxicity of chemicals based on in vitro evaluation by a combination of the Multi-ImmunoTox assay and the IL-8 Luc assay. Arch Toxicol. 2018 Jun;92(6):2043-2054. doi: 10.1007/s00204-018-2199-7. Epub 2018 Mar 29.
• [806] Spironolactone induces apoptosis in human mononuclear cells. Association between apoptosis and cytokine suppression. Apoptosis. 2006 Apr;11(4):573-9. doi: 10.1007/s10495-006-4919-3.
• [807] p53-R175H mutant gains new function in regulation of doxorubicin-induced apoptosis. Int J Cancer. 2005 Apr 10;114(3):331-6. doi: 10.1002/ijc.20818.
• [808] Azidothymidine and cisplatin increase p14ARF expression in OVCAR-3 ovarian cancer cell line. Toxicol Appl Pharmacol. 2006 Oct 1;216(1):89-97. doi: 10.1016/j.taap.2006.04.015. Epub 2006 May 19.
• [809] Quantitative analysis of gene expression changes in response to genotoxic compounds. Toxicol In Vitro. 2017 Mar;39:15-28. doi: 10.1016/j.tiv.2016.11.004. Epub 2016 Nov 5.
• [810] Induction of apoptosis by cidofovir in human papillomavirus (HPV)-positive cells. Oncol Res. 2000;12(9-10):397-408. doi: 10.3727/096504001108747855.
• [811] Gallic acid potentiates the apoptotic effect of paclitaxel and carboplatin via overexpression of Bax and P53 on the MCF-7 human breast cancer cell line. J Biochem Mol Toxicol. 2021 Feb;35(2):e22638. doi: 10.1002/jbt.22638. Epub 2020 Oct 1.
• [812] Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage. Nucleic Acids Res. 2009 Jan;37(1):78-95. doi: 10.1093/nar/gkn910. Epub 2008 Nov 16.
• [813] Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget. 2019 Jan 1;10(1):45-59. doi: 10.18632/oncotarget.26534. eCollection 2019 Jan 1.
• [814] Nitrogen Mustard Alkylates and Cross-Links p53 in Human Keratinocytes. Chem Res Toxicol. 2022 Apr 18;35(4):636-650. doi: 10.1021/acs.chemrestox.1c00420. Epub 2022 Mar 21.
• [815] Fulvestrant induces resistance by modulating GPER and CDK6 expression: implication of methyltransferases, deacetylases and the hSWI/SNF chromatin remodelling complex. Br J Cancer. 2013 Nov 12;109(10):2751-62. doi: 10.1038/bjc.2013.583. Epub 2013 Oct 29.
• [816] Effects of theophylline, dexamethasone and salbutamol on cytokine gene expression in human peripheral blood CD4+ T-cells. Eur Respir J. 1999 Nov;14(5):1106-12. doi: 10.1183/09031936.99.14511069.
• [817] Anti-mycotics suppress interleukin-4 and interleukin-5 production in anti-CD3 plus anti-CD28-stimulated T cells from patients with atopic dermatitis. J Invest Dermatol. 2001 Dec;117(6):1635-46. doi: 10.1046/j.0022-202x.2001.01566.x.
• [818] Ribavirin polarizes human T cell responses towards a Type 1 cytokine profile. J Hepatol. 1999 Mar;30(3):376-82. doi: 10.1016/s0168-8278(99)80093-2.
• [819] Selective inhibition of interleukin-4 gene expression in human T cells by aspirin. Blood. 2001 Mar 15;97(6):1742-9. doi: 10.1182/blood.v97.6.1742.
• [820] Immune responses in autoimmune hepatitis: effect of prednisone and azathioprine treatment: case report. Int J Med Sci. 2009 Jun 30;6(4):177-83. doi: 10.7150/ijms.6.177.
• [821] Differential effects of three antibiotics on T helper cell cytokine expression. J Antimicrob Chemother. 2005 Sep;56(3):502-6. doi: 10.1093/jac/dki251. Epub 2005 Jul 8.
• [822] Paradoxical immunologic effects of 2-CdA therapy: comment on the article by Davis et al. Arthritis Rheum. 1998 Sep;41(9):1704-5. doi: 10.1002/1529-0131(199809)41:9<1704::AID-ART26>3.0.CO;2-9.
• [823] Estrogen utilization of IGF-1-R and EGF-R to signal in breast cancer cells. J Steroid Biochem Mol Biol. 2010 Feb 28;118(4-5):219-30. doi: 10.1016/j.jsbmb.2009.09.018. Epub 2009 Oct 6.
• [824] Implication of the insulin-like growth factor-IR pathway in the resistance of non-small cell lung cancer cells to treatment with gefitinib. Clin Cancer Res. 2007 May 1;13(9):2795-803. doi: 10.1158/1078-0432.CCR-06-2077.
• [825] Simvastatin inhibits the proliferation of human prostate cancer PC-3 cells via down-regulation of the insulin-like growth factor 1 receptor. Biochem Biophys Res Commun. 2008 Jul 25;372(2):356-61. doi: 10.1016/j.bbrc.2008.05.043. Epub 2008 May 19.
• [826] Arsenic trioxide and cisplatin synergism increase cytotoxicity in human ovarian cancer cells: therapeutic potential for ovarian cancer. Cancer Sci. 2009 Dec;100(12):2459-64.
• [827] Rapamycin sensitizes multiple myeloma cells to apoptosis induced by dexamethasone. Blood. 2004 Apr 15;103(8):3138-47. doi: 10.1182/blood-2003-05-1543. Epub 2003 Dec 24.
• [828] EGFR tyrosine kinase inhibitors activate autophagy as a cytoprotective response in human lung cancer cells. PLoS One. 2011;6(6):e18691. doi: 10.1371/journal.pone.0018691. Epub 2011 Jun 2.
• [829] Oxidative stress induces parallel autophagy and mitochondria dysfunction in human glioma U251 cells. Toxicol Sci. 2009 Aug;110(2):376-88. doi: 10.1093/toxsci/kfp101. Epub 2009 May 18.
• [830] Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner. Clin Cancer Res. 2012 Aug 15;18(16):4345-55. doi: 10.1158/1078-0432.CCR-11-3227. Epub 2012 Jun 25.
• [831] Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105.
• [832] SU5416 inhibited VEGF and HIF-1alpha expression through the PI3K/AKT/p70S6K1 signaling pathway. Biochem Biophys Res Commun. 2004 Nov 12;324(2):471-80. doi: 10.1016/j.bbrc.2004.09.082.
• [833] D-glucosamine down-regulates HIF-1alpha through inhibition of protein translation in DU145 prostate cancer cells. Biochem Biophys Res Commun. 2009 Apr 24;382(1):96-101. doi: 10.1016/j.bbrc.2009.02.129. Epub 2009 Feb 28.
• [834] Arsenic trioxide inhibits translation of mRNA of bcr-abl, resulting in attenuation of Bcr-Abl levels and apoptosis of human leukemia cells. Cancer Res. 2003 Nov 15;63(22):7950-8.
• [835] Treatment with anticancer agents induces dysregulation of specific Wnt signaling pathways in human ovarian luteinized granulosa cells in vitro. Toxicol Sci. 2013 Nov;136(1):183-92. doi: 10.1093/toxsci/kft175. Epub 2013 Aug 16.
• [836] Progesterone increases csk homologous kinase in HMC-1560 human mast cells and reduces cell proliferation. J Cell Biochem. 2007 Dec 1;102(5):1271-80. doi: 10.1002/jcb.21357.
• [837] Cannabidiol upregulates melanogenesis through CB1 dependent pathway by activating p38 MAPK and p42/44 MAPK. Chem Biol Interact. 2017 Aug 1;273:107-114. doi: 10.1016/j.cbi.2017.06.005. Epub 2017 Jun 7.
• [838] Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2. Int J Cancer. 2006 Mar 15;118(6):1370-80. doi: 10.1002/ijc.21537.
• [839] Estrogen and pure antiestrogen fulvestrant (ICI 182 780) augment cell-matrigel adhesion of MCF-7 breast cancer cells through a novel G protein coupled estrogen receptor (GPR30)-to-calpain signaling axis. Toxicol Appl Pharmacol. 2014 Mar 1;275(2):176-81. doi: 10.1016/j.taap.2014.01.005. Epub 2014 Jan 17.
• [840] Inhibition of activator protein 1 by barbiturates is mediated by differential effects on mitogen-activated protein kinases and the small G proteins ras and rac-1. J Pharmacol Exp Ther. 2004 Dec;311(3):1232-40. doi: 10.1124/jpet.104.071332. Epub 2004 Jul 19.
• [841] Growth of hormone-dependent MCF-7 breast cancer cells is promoted by constitutive caveolin-1 whose expression is lost in an EGF-R-mediated manner during development of tamoxifen resistance. Breast Cancer Res Treat. 2010 Feb;119(3):575-91. doi: 10.1007/s10549-009-0355-8. Epub 2009 Mar 15.
• [842] Effect of histamine H1 receptor antagonists on TARC/CCL17 and MDC/CCL22 production from CD14+ cells induced by antigenic stimulation in vitro. Int Arch Allergy Immunol. 2011;155(1):38-51. doi: 10.1159/000318720. Epub 2010 Nov 25.
• [843] SIRT3 Mediates the Antioxidant Effect of Hydrogen Sulfide in Endothelial Cells. Antioxid Redox Signal. 2016 Feb 20;24(6):329-43. doi: 10.1089/ars.2015.6331. Epub 2015 Nov 10.
• [844] Downregulation of mitogen-activated protein kinases (MAPKs) in chronic ethanol-induced fatty liver. Toxicol Mech Methods. 2020 Jul;30(6):407-416. doi: 10.1080/15376516.2020.1747126. Epub 2020 Apr 1.
• [845] A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16657-62. doi: 10.1073/pnas.0707936104. Epub 2007 Oct 9.
• [846] The stent-eluting drugs sirolimus and paclitaxel suppress healing of the endothelium by induction of autophagy. Am J Pathol. 2009 Nov;175(5):2226-34.
• [847] Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids. J Biol Chem. 2005 Sep 9;280(36):31498-507. doi: 10.1074/jbc.M505537200. Epub 2005 Jul 13.
• [848] eIF4E is a critical regulator of human papillomavirus (HPV)-immortalized cervical epithelial (H8) cell growth induced by nicotine. Toxicology. 2019 May 1;419:1-10. doi: 10.1016/j.tox.2019.02.017. Epub 2019 Mar 2.
• [849] Repression of Kisspeptin1 weakens hydrogen peroxide-caused injury in HTR8 cells via adjusting PI3K/AKT/mTOR pathway. J Biochem Mol Toxicol. 2020 May;34(5):e22461. doi: 10.1002/jbt.22461. Epub 2020 Feb 11.
• [850] Ribavirin augments doxorubicin's efficacy in human hepatocellular carcinoma through inhibiting doxorubicin-induced eIF4E activation. J Biochem Mol Toxicol. 2018 Jan;32(1). doi: 10.1002/jbt.22007. Epub 2017 Nov 7.
• [851] Establishment of a 13 genes-based molecular prediction score model to discriminate the neurotoxic potential of food relevant-chemicals. Toxicol Lett. 2022 Feb 1;355:1-18. doi: 10.1016/j.toxlet.2021.10.013. Epub 2021 Nov 5.
• [852] Quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting VEGFR- 2 regulated AKT/mTOR/P70S6K signaling pathways. PLoS One. 2012;7(10):e47516. doi: 10.1371/journal.pone.0047516. Epub 2012 Oct 18.
• [853] Hydroquinone-induced endoplasmic reticulum stress affects TK6 cell autophagy and apoptosis via ATF6-mTOR. Environ Toxicol. 2023 Aug;38(8):1874-1890. doi: 10.1002/tox.23814. Epub 2023 May 6.
• [854] Simvastatin and lovastatin inhibit breast cell invasion induced by H-Ras. Oncol Rep. 2009 May;21(5):1317-22. doi: 10.3892/or_00000357.
• [855] Positive signaling interactions between arsenic and ethanol for angiogenic gene induction in human microvascular endothelial cells. Toxicol Sci. 2008 Apr;102(2):319-27. doi: 10.1093/toxsci/kfn003. Epub 2008 Jan 8.
• [856] NRF2 transcriptionally activates the heat shock factor 1 promoter under oxidative stress and affects survival and migration potential of MCF7 cells. J Biol Chem. 2018 Dec 14;293(50):19303-19316. doi: 10.1074/jbc.RA118.003376. Epub 2018 Oct 11.
• [857] A Gene Expression Biomarker Predicts Heat Shock Factor 1 Activation in a Gene Expression Compendium. Chem Res Toxicol. 2021 Jul 19;34(7):1721-1737. doi: 10.1021/acs.chemrestox.0c00510. Epub 2021 Jun 25.
• [858] Non-steroidal anti-inflammatory drugs inhibit the expression of cytokines and induce HSP70 in human monocytes. Cytokine. 1999 May;11(5):347-58. doi: 10.1006/cyto.1998.0437.
• [859] Simvastatin induces heat shock factor 1 in vascular endothelial cells. Atherosclerosis. 2006 Oct;188(2):265-73. doi: 10.1016/j.atherosclerosis.2005.10.045. Epub 2005 Dec 20.
• [860] Inhibition of phosphatidylinostol 3-kinase uncouples H2O2-induced senescent phenotype and cell cycle arrest in normal human diploid fibroblasts. Exp Cell Res. 2004 Aug 1;298(1):188-96. doi: 10.1016/j.yexcr.2004.04.012.
• [861] Combination of all-trans retinoic acid and paclitaxel-induced differentiation and apoptosis in human glioblastoma U87MG xenografts in nude mice. Cancer. 2008 Feb 1;112(3):596-607. doi: 10.1002/cncr.23223.
• [862] Characterization of cell death induced by ethacrynic acid in a human colon cancer cell line DLD-1 and suppression by N-acetyl-L-cysteine. Cancer Sci. 2003 Oct;94(10):886-93.
• [863] Dominant roles of the Raf/MEK/ERK pathway in cell cycle progression, prevention of apoptosis and sensitivity to chemotherapeutic drugs. Cell Cycle. 2010 Apr 15;9(8):1629-38. doi: 10.4161/cc.9.8.11487. Epub 2010 Apr 15.
• [864] Expression of the retinoic acid-metabolizing enzyme CYP26A1 limits programmed cell death. Mol Pharmacol. 2005 May;67(5):1808-17. doi: 10.1124/mol.104.005769. Epub 2005 Feb 9.
• [865] Role of BAX in the apoptotic response to anticancer agents. Science. 2000 Nov 3;290(5493):989-92. doi: 10.1126/science.290.5493.989.
• [866] Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/ 5-fluorocytosine suicide gene therapy-induced cell death in glioma cells. Oncogene. 2005 Feb 10;24(7):1231-43. doi: 10.1038/sj.onc.1208290.
• [867] Simvastatin induces apoptosis in human colon cancer cells and in tumor xenografts, and attenuates colitis-associated colon cancer in mice. Int J Cancer. 2008 Aug 15;123(4):951-7. doi: 10.1002/ijc.23593.
• [868] Hedgehog signaling antagonist GDC-0449 (Vismodegib) inhibits pancreatic cancer stem cell characteristics: molecular mechanisms. PLoS One. 2011;6(11):e27306. doi: 10.1371/journal.pone.0027306. Epub 2011 Nov 8.
• [869] Arsenic trioxide prevents osteosarcoma growth by inhibition of GLI transcription via DNA damage accumulation. PLoS One. 2013 Jul 8;8(7):e69466. doi: 10.1371/journal.pone.0069466. Print 2013.
• [870] A fine-needle aspirate-based vulnerability assay identifies polo-like kinase 1 as a mediator of gemcitabine resistance in pancreatic cancer. Mol Cancer Ther. 2010 Feb;9(2):311-8. doi: 10.1158/1535-7163.MCT-09-0693. Epub 2010 Jan 26.
• [871] Polymorphisms of ACE2 gene are associated with essential hypertension and antihypertensive effects of Captopril in women. Clin Pharmacol Ther. 2007 Aug;82(2):187-96. doi: 10.1038/sj.clpt.6100214. Epub 2007 May 2.
• [872] Inhibition of glutathione S-transferases by antimalarial drugs possible implications for circumventing anticancer drug resistance. Int J Cancer. 2002 Feb 10;97(5):700-5.
• [873] Human glutathione S-transferase A (GSTA) family genes are regulated by steroidogenic factor 1 (SF-1) and are involved in steroidogenesis. FASEB J. 2013 Aug;27(8):3198-208. doi: 10.1096/fj.12-222745. Epub 2013 May 6.
• [874] Polymorphisms of drug-metabolizing enzymes (GST, CYP2B6 and CYP3A) affect the pharmacokinetics of thiotepa and tepa. Br J Clin Pharmacol. 2009 Jan;67(1):50-60. doi: 10.1111/j.1365-2125.2008.03321.x. Epub 2008 Nov 17.
• [875] Effects of phenytoin on glutathione status and oxidative stress biomarker gene mRNA levels in cultured precision human liver slices. Toxicol Sci. 2001 Jan;59(1):118-26.
• [876] Acetaminophen-induced hepatocyte injury: C2-ceramide and oltipraz intervention, hepatocyte nuclear factor 1 and glutathione S-transferase A1 changes. J Appl Toxicol. 2019 Dec;39(12):1640-1650. doi: 10.1002/jat.3881. Epub 2019 Aug 6.
• [877] Antineoplastic drug sensitivity of human MCF-7 breast cancer cells stably transfected with a human alpha class glutathione S-transferase gene. Cancer Res. 1991 Jan 15;51(2):587-94.
• [878] Establishment of cisplatin-resistant ovarian yolk sac tumor cells and investigation of the mechanism of cisplatin resistance using this cell line. Gynecol Obstet Invest. 2011;71(2):104-11. doi: 10.1159/000320744. Epub 2010 Dec 9.
• [879] Overexpression of glutathione S-transferase A1-1 in ECV 304 cells protects against busulfan mediated G2-arrest and induces tissue factor expression. Br J Pharmacol. 2002 Dec;137(7):1100-6. doi: 10.1038/sj.bjp.0704972.
• [880] A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury. Nat Genet. 2010 Aug;42(8):711-4. doi: 10.1038/ng.632. Epub 2010 Jul 18.
• [881] Glucocorticoid regulation of human eosinophil gene expression. J Steroid Biochem Mol Biol. 2003 Mar;84(4):441-52. doi: 10.1016/s0960-0760(03)00065-7.
• [882] Transcriptomics and methylomics of CD4-positive T cells in arsenic-exposed women. Arch Toxicol. 2017 May;91(5):2067-2078. doi: 10.1007/s00204-016-1879-4. Epub 2016 Nov 12.
• [883] Gene expression responses reflecting 5-FU-induced toxicity: Comparison between patient colon tissue and 3D human colon organoids. Toxicol Lett. 2022 Dec 1;371:17-24. doi: 10.1016/j.toxlet.2022.09.013. Epub 2022 Sep 29.
• [884] HLA-DQA1-HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants. Nat Genet. 2014 Oct;46(10):1131-4. doi: 10.1038/ng.3093. Epub 2014 Sep 14.
• [885] Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis. Chem Res Toxicol. 2015 May 18;28(5):927-34. doi: 10.1021/tx5005248. Epub 2015 Apr 3.
• [886] Sulfur mustard alkylates steroid hormones and impacts hormone function in vitro. Arch Toxicol. 2019 Nov;93(11):3141-3152. doi: 10.1007/s00204-019-02571-x. Epub 2019 Sep 12.