Details of Disease

General Information of Disease (ID: DISXA7GG)

Disease Name End-stage renal disease
Synonyms
renal disease, end stage; renal disease (ESRD), end stage; end stage renal disease (ESRD); end stage renal disease; end stage kidney failure; end stage kidney disease; disease (ESRD), end stage renal; chronic kidney disease, stage 5; ESRD, end stage renal disease; ESRD
Disease Class GB61: Chronic kidney disease
Definition Long-standing and persistent renal disease with glomerular filtration rate (GFR) less than 15 ml/min.
Disease Hierarchy
DISW82R7: Chronic kidney disease
DISXA7GG: End-stage renal disease
ICD Code
ICD-11
ICD-11: GB61.5
ICD-10
ICD-10: N18.5
Expand ICD-11
'GB61.5
Expand ICD-10
'N18.5
Disease Identifiers
MONDO ID
MONDO_0004375
UMLS CUI
C2316810
MedGen ID
384526
HPO ID
HP:0003774
SNOMED CT ID
433146000

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 2 Clinical Trial Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
ASC-J9 DMDQS4W Phase 2 Small molecular drug [1]
AB023 DMBG9HI Phase 1 Antibody [2]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 95 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
AHSG TTKF4WV Limited Altered Expression [3]
B2M TTY7FKA Limited Altered Expression [4]
BDKRB2 TTGY8IW Limited Genetic Variation [5]
FN1 TTPJ921 Limited Biomarker [6]
GLA TTIS03D Limited Genetic Variation [7]
GNG7 TTCMBKF Limited Genetic Variation [8]
KLK4 TT4319X Limited Genetic Variation [9]
KLKB1 TTN0PCX Limited Biomarker [10]
MTM1 TTY2TCU Limited Biomarker [11]
NRG4 TTWAGKJ Limited Biomarker [12]
PCSK7 TTD30LY Limited Altered Expression [13]
POR TTOQ9GZ Limited Genetic Variation [14]
SLC17A5 TTFSUIA Limited Biomarker [15]
SLCO2B1 TTDL3UZ Limited Biomarker [16]
SOST TTYRO4F Limited Biomarker [17]
ADAMTS13 TTUREBK Disputed Biomarker [18]
RGMA TTURJV4 Disputed Genetic Variation [19]
ATP4A TTF1QVM moderate Genetic Variation [20]
CCR5 TTJIH8Q moderate Genetic Variation [21]
GNAO1 TTAXD8Z moderate Genetic Variation [22]
GSTA1 TT4P8DE moderate Genetic Variation [23]
HLA-DQB2 TTL7VOU moderate Genetic Variation [22]
KCNJ1 TTJ13ST moderate Genetic Variation [24]
KIR2DS1 TTVWAGF moderate Genetic Variation [25]
KIR2DS2 TTV3CFI moderate Biomarker [25]
KIR3DL2 TTQH3N0 moderate Biomarker [25]
LIMK2 TTASMD8 moderate Biomarker [26]
MAP2K5 TTV3O87 moderate Biomarker [27]
SIK1 TT1H6LC moderate Genetic Variation [19]
SLC19A3 TT9BTWM moderate Genetic Variation [28]
TRPV2 TTBECWA moderate Biomarker [29]
VKORC1 TTEUC8H moderate Genetic Variation [30]
ABCB1 TT3OT40 Strong Genetic Variation [31]
ABCC2 TTFLHJV Strong Biomarker [32]
ABCC3 TTVLG21 Strong Biomarker [32]
ACAT1 TTK3C21 Strong Biomarker [33]
ARG2 TTV1AG6 Strong Biomarker [34]
BDKRB1 TTG5QIA Strong Genetic Variation [35]
BECN1 TT5M7LN Strong Biomarker [36]
CLCNKB TTR68GQ Strong Genetic Variation [37]
CUBN TT9YLCR Strong Biomarker [38]
CX3CR1 TT2T98G Strong Altered Expression [39]
CYBB TT5T8MR Strong Altered Expression [40]
CYP11B2 TT9MNE2 Strong Genetic Variation [41]
DDC TTN451K Strong Biomarker [42]
DRD1 TTZFYLI Strong Therapeutic [43]
EDN1 TTJR60Z Strong Genetic Variation [44]
EHMT1 TTOFXD7 Strong Genetic Variation [45]
ENPP1 TTZTIWS Strong Biomarker [46]
EPOR TTAUX24 Strong Biomarker [47]
F2 TT6L509 Strong Therapeutic [48]
FCAR TTGUJAO Strong Biomarker [49]
FCGR3A TTIFOC0 Strong Altered Expression [50]
FGF21 TTQ916P Strong Altered Expression [51]
GCG TT6Y4PN Strong Biomarker [52]
GIP TT40HS5 Strong Altered Expression [52]
GLP1R TTVIMDE Strong Biomarker [53]
GSN TTUH7OM Strong Biomarker [54]
HMGCR TTPADOQ Strong Biomarker [55]
ICAM1 TTA1L39 Strong Genetic Variation [56]
IL20 TTNZMY2 Strong Biomarker [57]
IRS1 TTAJSQ0 Strong Biomarker [58]
KEAP1 TT3Z6Y9 Strong Biomarker [59]
KLK1 TT5T3P6 Strong Biomarker [43]
KNG1 TTDJ4MY Strong Genetic Variation [5]
LCAT TTGZ91P Strong Biomarker [60]
LHCGR TT2O4W9 Strong Biomarker [61]
LPL TTOF3WZ Strong Biomarker [62]
LTB TTHQ6US Strong Altered Expression [63]
MUC1 TTBHFYQ Strong Genetic Variation [64]
NEK8 TT8AH9I Strong Genetic Variation [65]
NOS1 TTZUFI5 Strong Therapeutic [66]
NR3C1 TTOZRK6 Strong Genetic Variation [67]
OLR1 TTKSND3 Strong Biomarker [68]
PGF TT48I1Y Strong Biomarker [69]
PLAU TTGY7WI Strong Biomarker [70]
POSTN TT8ALTZ Strong Biomarker [71]
PRTN3 TT5MLC4 Strong Genetic Variation [72]
PTGER4 TT79WV3 Strong Therapeutic [73]
PTH1R TTFPD47 Strong Altered Expression [74]
SCGB1A1 TTONPVW Strong Genetic Variation [75]
SERPINE1 TTTO43N Strong Therapeutic [76]
SLC12A3 TTP362L Strong Genetic Variation [77]
SLC5A2 TTF8JAT Strong Biomarker [78]
SOAT2 TTAK0IN Strong Biomarker [79]
ST8SIA4 TTDP8YM Strong Genetic Variation [80]
LRP2 TTPH1AJ Definitive Biomarker [81]
MTOR TTCJG29 Definitive Therapeutic [82]
PCSK9 TTNIZ2B Definitive Biomarker [83]
PDXP TT9UYG4 Definitive Biomarker [84]
SELP TTE5VG0 Definitive Biomarker [4]
SLC22A2 TT0XOJN Definitive Biomarker [85]
SREBF2 TTRQ4AP Definitive Biomarker [86]
TRPC6 TTRBT3W Definitive Biomarker [87]
WT1 TTZ8UT4 Definitive Genetic Variation [88]
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⏷ Show the Full List of 95 DTT(s)
This Disease Is Related to 8 DTP Molecule(s)
Gene Name DTP ID Evidence Level Mode of Inheritance REF
SLC4A1 DTB0Q3P Limited Genetic Variation [89]
SLC3A1 DTBCKVM Disputed Genetic Variation [90]
ATP12A DT5NLZA moderate Genetic Variation [20]
SLC24A5 DTAWCS9 moderate Genetic Variation [19]
SLC7A7 DTE4HJ8 Strong Genetic Variation [91]
SLC9A6 DTN0JXW Strong Biomarker [92]
SLC9C1 DT9J8DO Strong Genetic Variation [93]
SLC34A1 DT42EWA Definitive Biomarker [94]
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⏷ Show the Full List of 8 DTP(s)
This Disease Is Related to 6 DME Molecule(s)
Gene Name DME ID Evidence Level Mode of Inheritance REF
ABO DESIA7R Strong Biomarker [95]
ACP5 DESITDW Strong Biomarker [17]
APRT DE2MV1R Strong Altered Expression [96]
CYP1A1 DE6OQ3W Strong Biomarker [97]
GSTT1 DE3PKUG Strong Genetic Variation [98]
NAT2 DER7TA0 Strong Biomarker [99]
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⏷ Show the Full List of 6 DME(s)
This Disease Is Related to 139 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
ATF7IP OTU6ZA7F Limited Genetic Variation [100]
CEBPZ OT11BATG Limited Biomarker [101]
CFHR1 OT72R16T Limited Genetic Variation [102]
CFHR3 OTYL8SDO Limited Genetic Variation [102]
CLTC OTBFASMA Limited Genetic Variation [89]
CPD OT2CS64Y Limited Genetic Variation [103]
DNAJB9 OT38EQT6 Limited Biomarker [104]
ENHO OT91QASK Limited Biomarker [105]
EPB41L4B OT2K30P7 Limited Biomarker [11]
ERFE OTSES1HA Limited Biomarker [106]
ESPN OT7Z6LX2 Limited Biomarker [107]
ETF1 OTH8C5U5 Limited Genetic Variation [108]
FNDC5 OT5CSK9X Limited Altered Expression [109]
GOLGA6A OTHU9MRX Limited Biomarker [110]
GRAMD2B OTGT3E98 Limited Genetic Variation [8]
GYPA OTABU4YV Limited Biomarker [111]
KLF15 OTGMQMVR Limited Altered Expression [112]
KTN1 OTQAV541 Limited Biomarker [11]
MAMLD1 OT9EVMQY Limited Biomarker [11]
MGAT4C OTQ2R629 Limited Genetic Variation [8]
MTRF1 OTRTUUM4 Limited Genetic Variation [108]
NPHS1 OT21JD3P Limited Genetic Variation [113]
NUP42 OTADT64E Limited Biomarker [11]
OPTN OT2UXWH9 Limited Genetic Variation [114]
PKD2 OTIXBU8H Limited Genetic Variation [115]
PLA2G10 OTRZ2L5A Limited Altered Expression [116]
PRSS54 OTZVEVQZ Limited Biomarker [117]
PSMA6 OTJ6RPX5 Limited Genetic Variation [118]
PTER OTBYJHDG Limited Biomarker [119]
RBBP4 OTG3BT3M Limited Altered Expression [13]
SMARCA2 OTSGJ8SV Limited Genetic Variation [120]
SMARCAL1 OTTKXLUZ Limited Biomarker [120]
TMEM245 OTR7KEXW Limited Biomarker [11]
AFF3 OTR0705Z Disputed Genetic Variation [121]
FRMD3 OT0CD2GG Disputed Biomarker [87]
KIR3DL1 OTPOSXFX Disputed Biomarker [122]
MGP OTZWU3FU Disputed Altered Expression [123]
ABCG8 OTIJ76XW moderate Genetic Variation [124]
BSND OTYWZWPD moderate Altered Expression [125]
COL4A2 OTJK1LKN moderate Biomarker [126]
CORO7 OTG7MEAJ moderate Genetic Variation [127]
CPT2 OTIN6G20 moderate Altered Expression [128]
CREBRF OT2GK1HI moderate Genetic Variation [129]
CYBA OT16N9ZO moderate Genetic Variation [130]
DBP OTE0W7LN moderate Biomarker [131]
ELMO1 OTY2ORXK moderate Biomarker [132]
FCN1 OTK6ZHXH moderate Genetic Variation [133]
FLOT2 OTZ0QR5L moderate Biomarker [134]
FOXD3 OTXYV6GO moderate Biomarker [135]
KIR3DS1 OTJWIO4T moderate Genetic Variation [25]
MEIS1 OTH9DKAD moderate Genetic Variation [27]
MEST OT8Q4U8Y moderate Biomarker [136]
MTFMT OT1OIVJL moderate Genetic Variation [137]
PLCE1 OTJISZOX moderate Genetic Variation [138]
RFXANK OTDX1026 moderate Biomarker [139]
RNASE2 OT8Z4FNE moderate Genetic Variation [44]
RNLS OTVP2WJM moderate Genetic Variation [140]
RTN1 OTCX1SMK moderate Genetic Variation [141]
SCEL OT46SDNQ moderate Altered Expression [142]
SEMA6D OTU0UAZS moderate Genetic Variation [19]
SFI1 OTI1P52G moderate Biomarker [26]
SPESP1 OTWXKKTJ moderate Genetic Variation [143]
TINAG OTY7BSD7 moderate Genetic Variation [144]
TNIP1 OTRAOTEW moderate Genetic Variation [145]
ACTN4 OTCNZAJ5 Strong Biomarker [146]
ADIPOR1 OT65ZFZN Strong Biomarker [128]
ADIPOR2 OT2HDTL8 Strong Biomarker [147]
AQP2 OTQLBKK6 Strong Genetic Variation [148]
ARID4B OTYLPILE Strong Biomarker [149]
BGLAP OTK1YLWQ Strong Altered Expression [150]
BNIP3 OT4SO7J4 Strong Biomarker [36]
C6 OTCKR304 Strong ModifyingMutation [151]
CABIN1 OT4G5CIK Strong Biomarker [152]
CCL14 OT8QETQU Strong Biomarker [153]
CD151 OTF3UZS7 Strong Biomarker [154]
CD2AP OTC76KQM Strong Genetic Variation [155]
CHP1 OTHTXN1A Strong Biomarker [156]
CLCN5 OT9YXZSO Strong Genetic Variation [157]
CLDN16 OTTHAIKR Strong Genetic Variation [158]
CLDN19 OTVD6IBL Strong Genetic Variation [159]
CNDP1 OTOYSQG7 Strong Biomarker [160]
COL4A4 OT9G0MCT Strong Genetic Variation [161]
COL4A5 OTHG60RE Strong Genetic Variation [162]
COQ8B OTBY50BD Strong Genetic Variation [163]
DHX16 OTW8KZAU Strong Biomarker [164]
DNAJB11 OTDDK2SY Strong Biomarker [165]
EDN3 OTN7Q9BE Strong Genetic Variation [166]
ERAL1 OTSH78HD Strong Genetic Variation [167]
FGB OT6RKLI9 Strong Genetic Variation [168]
GALNT3 OT7M67WT Strong Biomarker [169]
GCKR OTSIWXGG Strong Genetic Variation [170]
GUCA2A OTUSF75G Strong Biomarker [171]
GUCA2B OTZERX04 Strong Biomarker [172]
HILPDA OTEID3ZM Strong Altered Expression [173]
INF2 OT8ZM13C Strong Biomarker [174]
KL OTD4VWU6 Strong Altered Expression [175]
KNSTRN OTYA7UXS Strong Biomarker [176]
LIPC OTZY5SC9 Strong Biomarker [177]
LPIN1 OTQ75KF2 Strong Biomarker [178]
MCTP2 OTFMZ8I2 Strong Genetic Variation [19]
MFN1 OTCBXQZF Strong Altered Expression [179]
MMP24 OTF8T3JM Strong Biomarker [180]
NPHP1 OTZHCFFQ Strong Biomarker [181]
NPHS2 OTLCNUII Strong Genetic Variation [182]
NXPH1 OTGKX860 Strong Biomarker [183]
PAPPA OTTTG9PG Strong Biomarker [184]
PAX2 OTKP1N8F Strong Genetic Variation [185]
PKD1 OT5ALRZ5 Strong Genetic Variation [186]
PLCL1 OTJL2C79 Strong Genetic Variation [138]
PLP1 OT8CM9CX Strong Genetic Variation [187]
POU2F3 OTIOOJWD Strong Genetic Variation [188]
PPP6R3 OTIXD60Q Strong Genetic Variation [189]
PTHLH OTI1JF13 Strong Altered Expression [190]
PTPRF OTH5KF2D Strong Genetic Variation [191]
RBM39 OTCMPTF9 Strong Biomarker [153]
RBM45 OTWTHD77 Strong Genetic Variation [192]
RHOV OTW4N3QN Strong Biomarker [156]
RREB1 OT62460U Strong Altered Expression [193]
SARNP OTE0OVK5 Strong Biomarker [153]
SDCCAG8 OTV2ZGV9 Strong Genetic Variation [194]
TPD52 OTPKSK43 Strong Genetic Variation [195]
TTC21B OTXXA87U Strong Genetic Variation [196]
BTBD9 OTWQ6GA3 Definitive Genetic Variation [197]
CFHR5 OT7BMOYE Definitive Genetic Variation [198]
CHGA OTXYX5JH Definitive Biomarker [199]
CXCL16 OTD49T9R Definitive Biomarker [200]
EXOSC3 OTNCF906 Definitive Biomarker [4]
GRHPR OTLV63QV Definitive Genetic Variation [201]
GTPBP4 OT6ZHAWC Definitive Biomarker [202]
HNF1B OTSYIC3T Definitive Genetic Variation [203]
HOGA1 OT7XETW4 Definitive Genetic Variation [201]
INVS OT8KPESR Definitive Genetic Variation [204]
LMX1B OTM8145D Definitive Genetic Variation [185]
NPHP3 OT8U8ELA Definitive Genetic Variation [204]
NT5C1A OTS7UF36 Definitive Genetic Variation [205]
RAPGEF5 OT53VS75 Definitive Genetic Variation [206]
RELA OTUJP9CN Definitive Biomarker [207]
RETN OTW5Z1NH Definitive Altered Expression [208]
S100A10 OTI71243 Definitive Biomarker [4]
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⏷ Show the Full List of 139 DOT(s)

References

1 ClinicalTrials.gov (NCT03612856) Safety and Efficacy Study of AB023 (Xisomab 3G3) in End Stage Renal Disease Patients on Chronic Hemodialysis. U.S. National Institutes of Health.
2 ClinicalTrials.gov (NCT03097341) Safety and Tolerability Study of Xisomab 3G3 in Healthy Adult Subjects. U.S. National Institutes of Health.
3 Chronic Kidney Disease Circulating Calciprotein Particles and Extracellular Vesicles Promote Vascular Calcification: A Role for GRP (Gla-Rich Protein).Arterioscler Thromb Vasc Biol. 2018 Mar;38(3):575-587. doi: 10.1161/ATVBAHA.117.310578. Epub 2018 Jan 4.
4 CD62P and P10 as predictive markers for assessing the efficacy of hemodialysis in treating end-stage renal disease.J Clin Lab Anal. 2019 Feb;33(2):e22662. doi: 10.1002/jcla.22662. Epub 2018 Oct 15.
5 Association of the human bradykinin B2 receptor gene with chronic renal failure.Mol Diagn. 2004;8(3):157-61. doi: 10.1007/BF03260059.
6 Fibronectin glomerulopathy complicated with persistent cloaca and congenital esophageal atresia: a case report and literature review.BMC Nephrol. 2017 Sep 6;18(1):288. doi: 10.1186/s12882-017-0704-5.
7 Mutation spectrum of -Galactosidase gene in Japanese patients with Fabry disease.J Hum Genet. 2019 Jul;64(7):695-699. doi: 10.1038/s10038-019-0599-z. Epub 2019 Apr 15.
8 Genome-wide association study identifies novel loci for type 2 diabetes-attributed end-stage kidney disease in African Americans.Hum Genomics. 2019 May 15;13(1):21. doi: 10.1186/s40246-019-0205-7.
9 Human tissue kallikrein gene delivery attenuates hypertension, renal injury, and cardiac remodeling in chronic renal failure.Kidney Int. 2000 Aug;58(2):730-9. doi: 10.1046/j.1523-1755.2000.00219.x.
10 Genomic structure of the human plasma prekallikrein gene, identification of allelic variants, and analysis in end-stage renal disease.Genomics. 2000 Oct 15;69(2):225-34. doi: 10.1006/geno.2000.6330.
11 A grading system that predicts the risk of dialysis induction in IgA nephropathy patients based on the combination of the clinical and histological severity.Clin Exp Nephrol. 2019 Jan;23(1):16-25. doi: 10.1007/s10157-018-1657-0. Epub 2018 Oct 26.
12 The brown fat-secreted adipokine neuregulin 4 is decreased in human and murine chronic kidney disease.Eur J Endocrinol. 2019 Aug;181(2):151-159. doi: 10.1530/EJE-19-0017.
13 A network-based variable selection approach for identification of modules and biomarker genes associated with end-stage kidney disease.Nephrology (Carlton). 2020 Oct;25(10):775-784. doi: 10.1111/nep.13655. Epub 2019 Sep 9.
14 Evaluation of the CPR video decision aid with patients with end stage renal disease.BMC Nephrol. 2018 Sep 12;19(1):226. doi: 10.1186/s12882-018-1018-y.
15 Potential Hepatoprotective Role of Galectin-3 during HCV Infection in End-Stage Renal Disease Patients.Dis Markers. 2017;2017:6275987. doi: 10.1155/2017/6275987. Epub 2017 Apr 11.
16 Uremic serum residue decreases SN-38 sensitivity through suppression of organic anion transporter polypeptide 2B1 in LS-180 colon cancer cells.Sci Rep. 2019 Oct 29;9(1):15464. doi: 10.1038/s41598-019-51640-9.
17 A distinct bone phenotype in ADPKD patients with end-stage renal disease.Kidney Int. 2019 Feb;95(2):412-419. doi: 10.1016/j.kint.2018.09.018.
18 Predictive value of ADAMTS-13 on concealed chronic renal failure in COPD patients.Int J Chron Obstruct Pulmon Dis. 2017 Dec 5;12:3495-3501. doi: 10.2147/COPD.S151983. eCollection 2017.
19 Novel genetic susceptibility loci for diabetic end-stage renal disease identified through robust naive Bayes classification.Diabetologia. 2014 Aug;57(8):1611-22. doi: 10.1007/s00125-014-3256-2. Epub 2014 May 29.
20 Associations of Proton-Pump Inhibitors and H2 Receptor Antagonists with Chronic Kidney Disease: A Meta-Analysis.Dig Dis Sci. 2017 Oct;62(10):2821-2827. doi: 10.1007/s10620-017-4725-5. Epub 2017 Aug 23.
21 Associations of fractalkine receptor (CX3CR1) and CCR5 gene variants with hypertension, diabetes and atherosclerosis in chronic renal failure patients undergoing hemodialysis.Int Urol Nephrol. 2016 Jul;48(7):1163-70. doi: 10.1007/s11255-016-1293-0. Epub 2016 Apr 27.
22 Human leucocyte antigens: their association with end-stage renal disease in Saudi patients awaiting transplantation.Br J Biomed Sci. 2012;69(4):159-63.
23 Associations of GSTM1*0 and GSTA1*A genotypes with the risk of cardiovascular death among hemodialyses patients.BMC Nephrol. 2014 Jan 14;15:12. doi: 10.1186/1471-2369-15-12.
24 Phenotype-genotype correlation in antenatal and neonatal variants of Bartter syndrome.Nephrol Dial Transplant. 2009 May;24(5):1455-64. doi: 10.1093/ndt/gfn689. Epub 2008 Dec 18.
25 Distribution of Killer cell immunoglobulin like receptor genes in end stage renal disease among North Indian population.Hum Immunol. 2013 Oct;74(10):1339-45. doi: 10.1016/j.humimm.2013.06.015. Epub 2013 Jun 15.
26 A genome-wide association study for diabetic nephropathy genes in African Americans.Kidney Int. 2011 Mar;79(5):563-72. doi: 10.1038/ki.2010.467. Epub 2010 Dec 8.
27 MEIS1 and BTBD9: genetic association with restless leg syndrome in end stage renal disease.J Med Genet. 2011 Jul;48(7):462-6. doi: 10.1136/jmg.2010.087858. Epub 2011 May 14.
28 Variation in SLC19A3 and Protection From Microvascular Damage in Type 1 Diabetes.Diabetes. 2016 Apr;65(4):1022-30. doi: 10.2337/db15-1247. Epub 2015 Dec 30.
29 Up-regulation of TRPV1 in mononuclear cells of end-stage kidney disease patients increases susceptibility to N-arachidonoyl-dopamine (NADA)-induced cell death.Biochim Biophys Acta. 2009 Oct;1792(10):1019-26. doi: 10.1016/j.bbadis.2009.07.008. Epub 2009 Jul 18.
30 Clinical and genetic factors influencing acenocoumarol dosing: a cross-sectional study.Blood Coagul Fibrinolysis. 2018 Sep;29(6):496-500. doi: 10.1097/MBC.0000000000000746.
31 Effect of MDR1 gene polymorphism on progression of end-stage renal disease.Acta Pharmacol Sin. 2007 Apr;28(4):579-83. doi: 10.1111/j.1745-7254.2007.00517.x.
32 Down-regulation of intestinal drug transporters in chronic renal failure in rats.J Pharmacol Exp Ther. 2007 Mar;320(3):978-85. doi: 10.1124/jpet.106.112631. Epub 2006 Nov 29.
33 Niacin improves renal lipid metabolism and slows progression in chronic kidney disease.Biochim Biophys Acta. 2010 Jan;1800(1):6-15. doi: 10.1016/j.bbagen.2009.10.009. Epub 2009 Oct 28.
34 Effect of chronic renal failure on arginase and argininosuccinate synthetase expression.Am J Nephrol. 2006;26(3):310-8. doi: 10.1159/000094344. Epub 2006 Jun 29.
35 Polymorphisms in the genes encoding for human kinin receptors and the risk of end-stage renal failure: results of transmission/disequilibrium test. The End-Stage Renal Disease Study Group.J Am Soc Nephrol. 1999 Oct;10(10):2120-4. doi: 10.1681/ASN.V10102120.
36 Mitochondrial impairment in the five-sixth nephrectomy model of chronic renal failure: proteomic approach.BMC Nephrol. 2013 Oct 4;14:209. doi: 10.1186/1471-2369-14-209.
37 Chronic renal failure in a boy with classic Bartter's syndrome due to a novel mutation in CLCNKB coding for the chloride channel.Eur J Pediatr. 2009 Sep;168(9):1129-33. doi: 10.1007/s00431-008-0883-y. Epub 2008 Dec 3.
38 Cubilin Single Nucleotide Polymorphism Variants are Associated with Macroangiopathy While a Matrix Metalloproteinase-9 Single Nucleotide Polymorphism Flip-Flop may Indicate Susceptibility of Diabetic Nephropathy in Type-2 Diabetic Patients.Nephron. 2019;141(3):156-165. doi: 10.1159/000494391. Epub 2018 Dec 17.
39 Indoxyl sulfate (IS)-mediated immune dysfunction provokes endothelial damage in patients with end-stage renal disease (ESRD).Sci Rep. 2017 Jun 8;7(1):3057. doi: 10.1038/s41598-017-03130-z.
40 Expansion of polymorphonuclear myeloid-derived suppressor cells in patients with end-stage renal disease may lead to infectious complications.Kidney Int. 2017 May;91(5):1236-1242. doi: 10.1016/j.kint.2016.12.015. Epub 2017 Feb 16.
41 Association between the A1166C polymorphism of the angiotensin II receptor type 1 and progression of chronic renal insufficiency.J Nephrol. 2003 May-Jun;16(3):357-64.
42 Renal dopaminergic system activity in rat remnant kidney up to twenty-six weeks after surgery.Life Sci. 2009 Mar 27;84(13-14):409-14. doi: 10.1016/j.lfs.2008.12.018. Epub 2009 Jan 8.
43 Delivery of recombinant adeno-associated virus-mediated human tissue kallikrein for therapy of chronic renal failure in rats.Hum Gene Ther. 2008 Apr;19(4):318-30. doi: 10.1089/hum.2007.138.
44 Associations of genetic variants of endothelin with cardiovascular complications in patients with renal failure.BMC Nephrol. 2017 Sep 7;18(1):291. doi: 10.1186/s12882-017-0707-2.
45 Comparison of the Effects of Glucagon-Like Peptide Receptor Agonists and Sodium-Glucose Cotransporter 2 Inhibitors for Prevention of Major Adverse Cardiovascular and Renal Outcomes in Type 2 Diabetes Mellitus.Circulation. 2019 Apr 23;139(17):2022-2031. doi: 10.1161/CIRCULATIONAHA.118.038868.
46 Insulin resistance and left ventricular hypertrophy in end-stage renal disease: association between the ENPP1 gene and left ventricular concentric remodelling.Nephrol Dial Transplant. 2012 Feb;27(2):661-6. doi: 10.1093/ndt/gfr281. Epub 2011 May 19.
47 Down-Regulation of Cardiac Erythropoietin Receptor and its Downstream Activated Signal Transducer Phospho-STAT-5 in a Rat Model of Chronic Kidney Disease.Isr Med Assoc J. 2016 Jun;18(6):326-30.
48 5/6 nephrectomy as a validated rat model mimicking human warfarin-related nephropathy.Am J Nephrol. 2012;35(4):356-64. doi: 10.1159/000337918. Epub 2012 Apr 2.
49 Immune complex formation in IgA nephropathy: CD89 a 'saint' or a 'sinner'?.Kidney Int. 2010 Dec;78(12):1211-3. doi: 10.1038/ki.2010.365.
50 Could there be Haemodynamic Stress Effects on Pro-Inflammatory CD14+CD16+ Monocytes during Convective-Diffusive Treatments? A Prospective Randomized Controlled Trial.Blood Purif. 2019;47(4):385-394. doi: 10.1159/000494711. Epub 2019 Jan 2.
51 Fibroblast growth factor 21 in chronic kidney disease.Clin Chim Acta. 2019 Feb;489:196-202. doi: 10.1016/j.cca.2017.11.002. Epub 2017 Nov 6.
52 Effect of the Incretin Hormones on the Endocrine Pancreas in End-Stage Renal Disease.J Clin Endocrinol Metab. 2020 Jan 1;105(1):dgz048. doi: 10.1210/clinem/dgz048.
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