Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMIAHVU)

• Drug Name: 2-deoxyglucose Drug Info
• Synonyms: 154-17-6; Deoxyglucose; 2-Deoxy-D-mannose; 2-Deoxy-D-arabinohexose; UNII-9G2MP84A8W; D-Arabino-hexose, 2-deoxy-; HSDB 5484; arabino-Hexose, 2-deoxy-; D-Glucose, 2-deoxy-; 9G2MP84A8W; (3R,4S,5R)-3,4,5,6-tetrahydroxyhexanal; AK-44445; 2 Deoxyglucose; 2 Deoxy D glucose; 2 Desoxy D glucose; D-arabino-2-desoxyhexose; d-2-glucodesose; D-2dGlc; deoxy-d-glucose, 2-; 2-DEOXYLGLUCOSE; 2-INNo-D-AEIIC; SCHEMBL7670; AC1L33KH; KSC175S5P; 4-01-00-04282 (Beilstein Handbook Reference); Jsp003004; CHEMBL2074932; CTK0H5957; MolPort-002-317-302; 2-deoxy-D-glucose

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Approved	[1]

• Cross-matching ID:
  PubChem CID: 108223
  CAS Number: CAS 154-17-6
  TTD Drug ID: DMIAHVU
  VARIDT Drug ID: DR00011

Molecule-Related Drug Atlas

Drug(s) Transported By Glucose transporter type 1, erythrocyte/brain (SLC2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[21]
D-glucose	DMMG2TO	Discovery agent	N.A.	Investigative	[22]
dehydroascorbic acid	DMKYQO4	Discovery agent	N.A.	Investigative	[23]
Arsenite	DMBCO4Q	Discovery agent	N.A.	Investigative	[24]

Drug(s) Transported By Glucose transporter type 14 (SLC2A14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
dehydroascorbic acid	DMKYQO4	Discovery agent	N.A.	Investigative	[9]

Drug(s) Transported By Glucose transporter type 7 (SLC2A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[6]

Drug(s) Transported By Sodium/glucose cotransporter 1 (SLC5A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fucose	DMAHMSV	N. A.	N. A.	Investigative	[10]

Drug(s) Transported By Sodium/glucose cotransporter 4 (SLC5A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[2]
D-mannose	DMT6X03	Discovery agent	N.A.	Investigative	[2]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[25]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[26]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[27]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[28]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[30]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[31]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 2 (SLC2A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[32]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[28]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[33]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[34]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[39]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[40]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[41]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[42]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[43]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[32]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[45]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[46]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[48]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[50]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[51]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[52]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[51]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[53]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[54]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[55]

Drug(s) Affected By Transmembrane protein 250 (TMEM250)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[14]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[14]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[56]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[57]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[58]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[14]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[59]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[60]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[61]

Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[62]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[63]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[66]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[67]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[70]

Drug(s) Affected By SLIT-ROBO Rho GTPase-activating protein 3 (SRGAP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[72]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[73]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[74]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[75]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[76]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[73]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[14]

Drug(s) Affected By Serine protease HTRA2, mitochondrial (HTRA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[77]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[70]
Bortezomib	DMNO38U	Leukemia		Approved	[83]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[84]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[85]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[86]
Fructose	DM43AN2	Vomiting	MD90	Approved	[87]
Ketoprofen	DMRKXPT	Bursitis		Approved	[87]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[88]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[89]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[90]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[91]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[92]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[93]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[94]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[95]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[96]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[97]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[97]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[99]
Selenium	DM25CGV	N. A.	N. A.	Approved	[100]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[101]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[102]

Drug(s) Affected By Integrin beta-1 (ITGB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[94]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[103]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[104]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[106]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[107]
Fructose	DM43AN2	Vomiting	MD90	Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[109]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[110]

Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[111]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[112]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[113]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[114]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[115]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[116]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[117]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[118]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[119]

Drug(s) Affected By Endoplasmin (HSP90B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[111]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[120]
Selenium	DM25CGV	N. A.	N. A.	Approved	[121]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[122]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[124]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[125]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[45]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[127]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[128]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[129]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[91]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[93]
Selenium	DM25CGV	N. A.	N. A.	Approved	[130]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[131]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[53]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[132]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[133]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[134]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[135]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[136]
Selenium	DM25CGV	N. A.	N. A.	Approved	[121]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[137]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[138]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[139]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[140]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[141]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[142]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[143]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[144]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[145]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[146]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[147]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[148]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[149]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[150]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[151]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[152]

Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[153]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[154]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[155]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[156]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[157]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[158]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[159]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[160]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[161]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[162]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[163]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[146]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[164]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[112]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[115]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[166]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[167]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]

Drug(s) Affected By Serpin B5 (SERPINB5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[168]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[169]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[171]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[171]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[172]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[173]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[165]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[174]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[175]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[176]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[177]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[178]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[179]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[180]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[181]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[182]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[183]

Drug(s) Affected By Collagenase 3 (MMP13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[184]
Clindamycin	DM15HL8	Acne vulgaris	ED80	Approved	[185]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[184]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[107]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[186]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[187]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[188]
Doxycycline	DM7ICNU	Acne vulgaris	ED80	Approved	[185]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[190]

Drug(s) Affected By Max-interacting protein 1 (MXI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[191]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[171]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[171]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[171]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[192]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[193]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[171]

Drug(s) Affected By Small ribosomal subunit protein eS6 (RPS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[194]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[28]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[195]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[160]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[196]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[197]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[199]
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[200]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[201]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[183]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[202]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[103]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[203]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[204]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[205]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[52]

Drug(s) Affected By Potassium voltage-gated channel subfamily H member 2 (KCNH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metoclopramide	DMFA5MY	Nausea	MD90	Approved	[206]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[207]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[208]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[209]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[209]
Disopyramide	DM5SYZP	Long QT syndrome	BC65.0	Approved	[210]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[211]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[212]
Dofetilide	DMPN1TW	Sinus rhythm disorder	BC9Y	Approved	[213]
Flecainide	DMSQDLE	Tachyarrhythmias	BC71	Approved	[209]

Drug(s) Affected By Unconventional myosin-Ie (MYO1E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[14]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[214]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[70]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[14]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[14]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[215]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[216]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[217]

Drug(s) Affected By Serine/threonine-protein kinase STK11 (STK11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[154]
Selenium	DM25CGV	N. A.	N. A.	Approved	[121]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[218]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[219]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[216]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[220]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[221]
GDC-0980/RG7422	DMF3MV1	Non-hodgkin lymphoma	2B33.5	Phase 2	[222]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[223]

Drug(s) Affected By 7SK snRNA methylphosphate capping enzyme (MEPCE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[224]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[214]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[14]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[215]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[58]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[225]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[226]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[227]

Drug(s) Affected By Transmembrane protein 87A (TMEM87A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[228]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[192]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[229]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[14]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[215]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[57]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[230]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[58]

Drug(s) Affected By Terminal nucleotidyltransferase 4B (TENT4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[14]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[231]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[226]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[232]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[227]
Scriptaid	DM9JZ21	Solid tumour/cancer	2A00-2F9Z	Preclinical	[14]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[60]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[233]

Drug(s) Affected By Lipase member H (LIPH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[228]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[234]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[14]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[14]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[216]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[235]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[236]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[237]

Drug(s) Affected By Small integral membrane protein 14 (SMIM14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[14]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[14]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[29]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[193]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[229]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[14]

Drug(s) Affected By Partner of Y14 and mago (PYM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[42]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[14]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[70]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[215]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[58]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[36]

Drug(s) Affected By Protein FAM117A (FAM117A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[228]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[14]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[238]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[214]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[14]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[215]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[14]

Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[154]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[239]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[168]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[240]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[241]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[242]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[243]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[244]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[245]

Drug(s) Affected By E3 ubiquitin-protein ligase Jade-2 (JADE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[44]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[246]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[247]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[193]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[248]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[58]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[14]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[246]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[249]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[250]

Drug(s) Affected By AP-5 complex subunit sigma-1 (AP5S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[14]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[14]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[214]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[229]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[215]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[14]
Pracinostat	DMTD7AB	Acute myeloid leukaemia	2A60	Phase 3	[14]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[59]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[14]

Drug(s) Affected By Kelch-like protein 42 (KLHL42)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[251]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[14]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[248]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[231]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[252]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[58]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[253]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[226]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[14]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[253]

Drug(s) Affected By Inactive cell surface hyaluronidase CEMIP2 (CEMIP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[70]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[254]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[229]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[14]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[14]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[215]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[74]

Drug(s) Affected By ERBB receptor feedback inhibitor 1 (ERRFI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[255]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[256]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[45]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[214]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[257]

Drug(s) Affected By Transmembrane and coiled-coil domain protein 3 (TMCC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[251]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[258]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[14]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[74]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[253]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[258]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[253]
MGCD-0103	DM726HX	Non-small-cell lung cancer	2C25.Y	Phase 2	[14]

Drug(s) Affected By RING finger protein 24 (RNF24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[79]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[14]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[259]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[253]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[14]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[56]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[57]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[58]

Drug(s) Affected By Sodium/potassium-transporting ATPase subunit gamma (FXYD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[214]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[260]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[72]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[74]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[261]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[217]
Spermidine	DMVJNFI	Plaque psoriasis	EA90.0	Phase 3	[262]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[36]

Drug(s) Affected By Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[263]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[264]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[265]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[266]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[267]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[268]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[146]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[32]
Selenium	DM25CGV	N. A.	N. A.	Approved	[130]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[269]

Drug(s) Affected By Alpha-2-macroglobulin (A2M)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[270]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[271]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[272]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[273]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[124]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[273]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[274]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Aminocaproic Acid	DMFGND4	Bleeding disorder	GA20-GA21	Approved	[271]

Drug(s) Affected By Adiponectin (ADIPOQ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[275]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[275]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[276]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[277]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[275]
Cilazapril	DM4V6JA	Congestive heart failure	BD10	Approved	[278]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[279]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[275]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[280]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[281]

Drug(s) Affected By Insulin (INS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[282]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[283]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[284]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[285]
Fructose	DM43AN2	Vomiting	MD90	Approved	[286]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[287]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[288]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[289]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[290]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[291]

Molecular Interaction Atlas of This Drug

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Sodium/glucose cotransporter 4 (SLC5A9)	DT1CP40	SC5A9_HUMAN	Substrate	[2]
Sodium/glucose cotransporter 3 (SLC5A4)	DTO4FLB	SC5A4_HUMAN	Substrate	[3]
Sodium/glucose cotransporter 5 (SLC5A10)	DTQNIG7	SC5AA_HUMAN	Substrate	[3]
Glucose transporter type 12 (SLC2A12)	DTA5QI0	GTR12_HUMAN	Substrate	[4]
Proton-associated sugar transporter A (SLC45A1)	DTMSNOU	S45A1_HUMAN	Substrate	[5]
Glucose transporter type 6 (SLC2A6)	DTS4MKQ	GTR6_HUMAN	Substrate	[6]
Glucose transporter type 4, insulin-responsive (SLC2A4)	DT4827A	GLUT4_HUMAN	Substrate	[7]
Glucose transporter type 3, brain (SLC2A3)	DT9SQ3L	GTR3_HUMAN	Substrate	[8]
Glucose transporter type 14 (SLC2A14)	DT18YD9	GTR14_HUMAN	Substrate	[9]
Sodium/glucose cotransporter 1 (SLC5A1)	DTOKC04	SC5A1_HUMAN	Substrate	[10]
Glucose transporter type 8 (SLC2A8)	DT2I7BM	GTR8_HUMAN	Substrate	[6]
Glucose transporter type 7 (SLC2A7)	DT8SQBG	GTR7_HUMAN	Substrate	[6]
Glucose transporter type 2, liver (SLC2A2)	DTUJPOL	GTR2_HUMAN	Substrate	[11]
Glucose transporter type 10 (SLC2A10)	DT3BI6S	GTR10_HUMAN	Substrate	[12]
Glucose transporter type 1, erythrocyte/brain (SLC2A1)	DTG3T6X	GTR1_HUMAN	Substrate	[13]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
7SK snRNA methylphosphate capping enzyme (MEPCE)	OTRBQEYP	MEPCE_HUMAN	Gene/Protein Processing	[14]
Adiponectin (ADIPOQ)	OTNX23LE	ADIPO_HUMAN	Regulation of Drug Effects	[15]
Alpha-2-macroglobulin (A2M)	OTFTX90K	A2MG_HUMAN	Regulation of Drug Effects	[16]
AP-5 complex subunit sigma-1 (AP5S1)	OTGS53SC	AP5S1_HUMAN	Gene/Protein Processing	[14]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[17]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Protein Interaction/Cellular Processes	[18]
Collagenase 3 (MMP13)	OTY8BZIE	MMP13_HUMAN	Gene/Protein Processing	[19]
DNA damage-inducible transcript 3 protein (DDIT3)	OTI8YKKE	DDIT3_HUMAN	Gene/Protein Processing	[18]
E3 ubiquitin-protein ligase Jade-2 (JADE2)	OTVG2MYF	JADE2_HUMAN	Gene/Protein Processing	[14]
Endoplasmic reticulum chaperone BiP (HSPA5)	OTFUIRAO	BIP_HUMAN	Gene/Protein Processing	[20]

References

• [1] ClinicalTrials.gov (NCT00633087) A Phase I/II Trial of 2-Deoxyglucose (2DG) for the Treatment of Advanced Cancer and Hormone Refractory Prostate Cancer. U.S. National Institutes of Health.
• [2] SLC5A9/SGLT4, a new Na+-dependent glucose transporter, is an essential transporter for mannose, 1,5-anhydro-D-glucitol, and fructose. Life Sci. 2005 Jan 14;76(9):1039-50.
• [3] The sodium/glucose cotransport family SLC5. Pflugers Arch. 2004 Feb;447(5):510-8.
• [4] The human facilitative glucose transporter GLUT12: Expression and regulation in Caco-2 and 3T3-L1cells.
• [5] Dysfunction of the Cerebral Glucose Transporter SLC45A1 in Individuals with Intellectual Disability and Epilepsy. Am J Hum Genet. 2017 May 4;100(5):824-830.
• [6] Functional Properties and Genomics of Glucose Transporters. Curr Genomics. 2007 Apr; 8(2): 113128.
• [7] Need for GLUT4 activation to reach maximum effect of insulin-mediated glucose uptake in brown adipocytes isolated from GLUT4myc-expressing mice. Diabetes. 2002 Sep;51(9):2719-26.
• [8] Ascorbic acid-dependent GLUT3 inhibition is a critical step for switching neuronal metabolism. J Cell Physiol. 2011 Dec;226(12):3286-94.
• [9] The SLC2A14 gene, encoding the novel glucose/dehydroascorbate transporter GLUT14, is associated with inflammatory bowel disease. Am J Clin Nutr. 2017 Dec;106(6):1508-1513.
• [10] The role of SGLT1 and GLUT2 in intestinal glucose transport and sensing. PLoS One. 2014 Feb 26;9(2):e89977.
• [11] GLUT2 (SLC2A2) is not the principal glucose transporter in human pancreatic beta cells: implications for understanding genetic association signals at this locus. Mol Genet Metab. 2011 Dec;104(4):648-53.
• [12] Sequence and functional analysis of GLUT10: a glucose transporter in the Type 2 diabetes-linked region of chromosome 20q12-13.1. Mol Genet Metab. 2001 Sep-Oct;74(1-2):186-99.
• [13] Glutamine 161 of Glut1 glucose transporter is critical for transport activity and exofacial ligand binding. J Biol Chem. 1994 Aug 12;269(32):20533-8.
• [14] Development and validation of the TGx-HDACi transcriptomic biomarker to detect histone deacetylase inhibitors in human TK6 cells. Arch Toxicol. 2021 May;95(5):1631-1645. doi: 10.1007/s00204-021-03014-2. Epub 2021 Mar 26.
• [15] A collagen domain-derived short adiponectin peptide activates APPL1 and AMPK signaling pathways and improves glucose and fatty acid metabolisms. J Biol Chem. 2018 Aug 31;293(35):13509-13523. doi: 10.1074/jbc.RA118.001801. Epub 2018 Jul 10.
• [16] Activated 2-macroglobulin binding to human prostate cancer cells triggers insulin-like responses. J Biol Chem. 2015 Apr 10;290(15):9571-87. doi: 10.1074/jbc.M114.617837. Epub 2015 Feb 26.
• [17] Cytotoxic effects of mithramycin DIG-MSK can depend on the rise of autophagy. Toxicol In Vitro. 2015 Oct;29(7):1537-44. doi: 10.1016/j.tiv.2015.06.008. Epub 2015 Jun 13.
• [18] 2-Deoxy-D-glucose activates autophagy via endoplasmic reticulum stress rather than ATP depletion. Cancer Chemother Pharmacol. 2011 Apr;67(4):899-910. doi: 10.1007/s00280-010-1391-0. Epub 2010 Jul 1.
• [19] IKK inibition by a glucosamine derivative enhances Maspin expression in osteosarcoma cell line. Chem Biol Interact. 2017 Jan 25;262:19-28. doi: 10.1016/j.cbi.2016.12.005. Epub 2016 Dec 6.
• [20] HHQ-4, a quinoline derivate, preferentially inhibits proliferation of glucose-deprived breast cancer cells as a GRP78 down-regulator. Toxicol Appl Pharmacol. 2019 Jun 15;373:10-25. doi: 10.1016/j.taap.2019.04.017. Epub 2019 Apr 22.
• [21] Oral Bioavailability and Disposition of Phytochemicals
• [22] The SLC2 (GLUT) family of membrane transporters. Mol Aspects Med. 2013 Apr-Jun;34(2-3):121-38.
• [23] Glucose transporter isoforms GLUT1 and GLUT3 transport dehydroascorbic acid. J Biol Chem. 1997 Jul 25;272(30):18982-9.
• [24] Mammalian glucose permease GLUT1 facilitates transport of arsenic trioxide and methylarsonous acid. Biochem Biophys Res Commun. 2006 Dec 15;351(2):424-30.
• [25] Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Redox Biol. 2020 Jan;28:101321. doi: 10.1016/j.redox.2019.101321. Epub 2019 Sep 5.
• [26] A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system. Toxicol Sci. 2005 Feb;83(2):282-92.
• [27] In vitro detection of drug-induced phospholipidosis using gene expression and fluorescent phospholipid based methodologies. Toxicol Sci. 2007 Sep;99(1):162-73.
• [28] Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
• [29] Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
• [30] Retinoic acid represses a cassette of candidate pluripotency chromosome 12p genes during induced loss of human embryonal carcinoma tumorigenicity. Biochim Biophys Acta. 2005 Oct 15;1731(1):48-56. doi: 10.1016/j.bbaexp.2005.08.006. Epub 2005 Sep 1.
• [31] Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23. doi: 10.1007/s00204-013-1169-3. Epub 2013 Nov 30.
• [32] Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
• [33] Rifampin Regulation of Drug Transporters Gene Expression and the Association of MicroRNAs in Human Hepatocytes. Front Pharmacol. 2016 Apr 26;7:111.
• [34] In vitro study of transporters involved in intestinal absorption of inorganic arsenic. Chem Res Toxicol. 2012 Feb 20;25(2):446-53. doi: 10.1021/tx200491f. Epub 2012 Jan 26.
• [35] Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
• [36] Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
• [37] Involvement of pregnane X receptor in the impaired glucose utilization induced by atorvastatin in hepatocytes. Biochem Pharmacol. 2016 Jan 15;100:98-111.
• [38] Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
• [39] The effect of folate status on the uptake of physiologically relevant compounds by Caco-2 cells. Eur J Pharmacol. 2010 Aug 25;640(1-3):29-37. doi: 10.1016/j.ejphar.2010.04.056. Epub 2010 May 11.
• [40] Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy. Med Oncol. 2011 Dec;28(4):1395-404. doi: 10.1007/s12032-010-9603-3. Epub 2010 Jul 2.
• [41] Effects of troglitazone on cellular differentiation, insulin signaling, and glucose metabolism in cultured human skeletal muscle cells. Biochem Biophys Res Commun. 2001 Jan 26;280(3):664-74. doi: 10.1006/bbrc.2000.4216.
• [42] Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
• [43] Disturbance of cellular glucose transport by two prevalently used fluoroquinolone antibiotics ciprofloxacin and levofloxacin involves glucose transporter type 1. Toxicol Lett. 2009 Jan 30;184(2):81-4. doi: 10.1016/j.toxlet.2008.10.017. Epub 2008 Oct 28.
• [44] Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
• [45] Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
• [46] Aluminum toxicity triggers the nuclear translocation of HIF-1alpha and promotes anaerobiosis in hepatocytes. Toxicol In Vitro. 2007 Feb;21(1):16-24. doi: 10.1016/j.tiv.2006.07.013. Epub 2006 Aug 5.
• [47] Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
• [48] Evidence of securin-mediated resistance to gefitinib-induced apoptosis in human cancer cells. Chem Biol Interact. 2013 Apr 25;203(2):412-22. doi: 10.1016/j.cbi.2013.03.011. Epub 2013 Mar 22.
• [49] Cigarette smoke and asbestos activate poly-ADP-ribose polymerase in alveolar epithelial cells. J Investig Med. 2001 Jan;49(1):68-76. doi: 10.2310/6650.2001.34092.
• [50] Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
• [51] The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation. J Biochem Mol Toxicol. 1999;13(6):338-47. doi: 10.1002/(sici)1099-0461(1999)13:6<338::aid-jbt8>3.0.co;2-7.
• [52] Ciprofloxacin mediated cell growth inhibition, S/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line. Clin Cancer Res. 2000 Mar;6(3):891-900.
• [53] Investigation of molecular mechanisms underlying the antiproliferative effects of colchicine against PC3 prostate cancer cells. Toxicol In Vitro. 2021 Jun;73:105138. doi: 10.1016/j.tiv.2021.105138. Epub 2021 Mar 6.
• [54] Sulindac enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human lung cancer. Mol Cancer Ther. 2005 Feb;4(2):291-304.
• [55] Methotrexate induces poly(ADP-ribose) polymerase-dependent, caspase 3-independent apoptosis in subsets of proliferating CD4+ T cells. Clin Exp Immunol. 2007 May;148(2):288-95. doi: 10.1111/j.1365-2249.2007.03335.x. Epub 2007 Feb 7.
• [56] Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
• [57] Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
• [58] Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
• [59] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
• [60] DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
• [61] Gene expression profile analysis of gallic acid-induced cell death process. Sci Rep. 2021 Aug 18;11(1):16743. doi: 10.1038/s41598-021-96174-1.
• [62] Transcriptomic Analysis of Stem Cells Treated with Moringin or Cannabidiol: Analogies and Differences in Inflammation Pathways. Int J Mol Sci. 2019 Nov 30;20(23):6039. doi: 10.3390/ijms20236039.
• [63] Activation of nuclear factor-kappa B pathway by simvastatin and RhoA silencing increases doxorubicin cytotoxicity in human colon cancer HT29 cells. Mol Pharmacol. 2008 Aug;74(2):476-84.
• [64] A peptidyl-glucosamine derivative affects IKKalpha kinase activity in human chondrocytes. Arthritis Res Ther. 2010;12(1):R18. doi: 10.1186/ar2920. Epub 2010 Jan 29.
• [65] Arsenic trioxide exerts antimyeloma effects by inhibiting activity in the cytoplasmic substrates of histone deacetylase 6. PLoS One. 2012;7(2):e32215. doi: 10.1371/journal.pone.0032215. Epub 2012 Feb 22.
• [66] THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
• [67] Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen. Oncogene. 1999 Dec 2;18(51):7389-94. doi: 10.1038/sj.onc.1203160.
• [68] Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
• [69] Antiepileptic drugs are endocrine disruptors for the human fetal testis ex vivo. Toxicol Sci. 2023 Sep 28;195(2):169-183. doi: 10.1093/toxsci/kfad076.
• [70] Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
• [71] Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
• [72] Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
• [73] Influence of resveratrol on rheumatoid fibroblast-like synoviocytes analysed with gene chip transcription. Phytomedicine. 2013 Feb 15;20(3-4):310-8. doi: 10.1016/j.phymed.2012.09.020. Epub 2012 Nov 6.
• [74] Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
• [75] Research resource: STR DNA profile and gene expression comparisons of human BG-1 cells and a BG-1/MCF-7 clonal variant. Mol Endocrinol. 2014 Dec;28(12):2072-81.
• [76] Cytosine arabinoside induces ectoderm and inhibits mesoderm expression in human embryonic stem cells during multilineage differentiation. Br J Pharmacol. 2011 Apr;162(8):1743-56.
• [77] Gingival Stromal Cells as an In Vitro Model: Cannabidiol Modulates Genes Linked With Amyotrophic Lateral Sclerosis. J Cell Biochem. 2017 Apr;118(4):819-828. doi: 10.1002/jcb.25757. Epub 2016 Nov 28.
• [78] Statin-triggered cell death in primary human lung mesenchymal cells involves p53-PUMA and release of Smac and Omi but not cytochrome c. Biochim Biophys Acta. 2010 Apr;1803(4):452-67. doi: 10.1016/j.bbamcr.2009.12.005. Epub 2010 Jan 4.
• [79] Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
• [80] Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Toxicol Appl Pharmacol. 2012 Jun 1;261(2):204-16.
• [81] Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
• [82] Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
• [83] Differential regulation of noxa in normal melanocytes and melanoma cells by proteasome inhibition: therapeutic implications. Cancer Res. 2005 Jul 15;65(14):6294-304. doi: 10.1158/0008-5472.CAN-05-0686.
• [84] Regulation of HtrA2/Omi by X-linked inhibitor of apoptosis protein in chemoresistance in human ovarian cancer cells. Gynecol Oncol. 2005 May;97(2):413-21. doi: 10.1016/j.ygyno.2004.12.055.
• [85] Indomethacin and juglone inhibit inflammatory molecules to induce apoptosis in colon cancer cells. J Biochem Mol Toxicol. 2020 Feb;34(2):e22433. doi: 10.1002/jbt.22433. Epub 2020 Jan 9.
• [86] A cell impedance-based real-time in vitro assay to assess the toxicity of amphotericin B formulations. Toxicol Appl Pharmacol. 2017 Nov 1;334:18-23. doi: 10.1016/j.taap.2017.08.017. Epub 2017 Sep 1.
• [87] ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
• [88] CBD Promotes Oral Ulcer Healing via Inhibiting CMPK2-Mediated Inflammasome. J Dent Res. 2022 Feb;101(2):206-215. doi: 10.1177/00220345211024528. Epub 2021 Jul 16.
• [89] Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
• [90] Anti-inflammatory effects of the GABA(B) receptor agonist baclofen in allergic contact dermatitis. Exp Dermatol. 2010 Jul 1;19(7):661-6. doi: 10.1111/j.1600-0625.2010.01076.x. Epub 2010 Feb 25.
• [91] Frankincense myrrh attenuates hepatocellular carcinoma by regulating tumor blood vessel development through multiple epidermal growth factor receptor-mediated signaling pathways. World J Gastrointest Oncol. 2022 Feb 15;14(2):450-477. doi: 10.4251/wjgo.v14.i2.450.
• [92] Sulfasalazine unveils a contact-independent HSV-TK/ganciclovir gene therapy bystander effect in malignant gliomas. Int J Oncol. 2007 Jan;30(1):283-90.
• [93] Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts. Biomed Res Int. 2015;2015:257090. doi: 10.1155/2015/257090. Epub 2015 Aug 3.
• [94] Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
• [95] ERE-independent ERalpha target genes differentially expressed in human breast tumors. Mol Cell Endocrinol. 2005 Dec 21;245(1-2):53-9. doi: 10.1016/j.mce.2005.10.003. Epub 2005 Nov 17.
• [96] Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction. J Toxicol Sci. 2020;45(11):673-680. doi: 10.2131/jts.45.673.
• [97] An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
• [98] Gypenosides protect retinal pigment epithelium cells from oxidative stress. Food Chem Toxicol. 2018 Feb;112:76-85.
• [99] (9)-Tetrahydrocannabinol Suppresses Monocyte-Mediated Astrocyte Production of Monocyte Chemoattractant Protein 1 and Interleukin-6 in a Toll-Like Receptor 7-Stimulated Human Coculture. J Pharmacol Exp Ther. 2019 Oct;371(1):191-201. doi: 10.1124/jpet.119.260661. Epub 2019 Aug 5.
• [100] Changes in gene expression profiles in response to selenium supplementation among individuals with arsenic-induced pre-malignant skin lesions. Toxicol Lett. 2007 Mar 8;169(2):162-76. doi: 10.1016/j.toxlet.2007.01.006. Epub 2007 Jan 19.
• [101] Profiling the immunotoxicity of chemicals based on in vitro evaluation by a combination of the Multi-ImmunoTox assay and the IL-8 Luc assay. Arch Toxicol. 2018 Jun;92(6):2043-2054. doi: 10.1007/s00204-018-2199-7. Epub 2018 Mar 29.
• [102] Spironolactone induces apoptosis in human mononuclear cells. Association between apoptosis and cytokine suppression. Apoptosis. 2006 Apr;11(4):573-9. doi: 10.1007/s10495-006-4919-3.
• [103] Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
• [104] Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res. 2002 Aug 1;62(15):4419-26.
• [105] Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
• [106] Distinct genetic profile in peripheral blood mononuclear cells of psoriatic arthritis patients treated with methotrexate and TNF-inhibitors. Clin Rheumatol. 2014 Dec;33(12):1815-21. doi: 10.1007/s10067-014-2807-8. Epub 2014 Oct 24.
• [107] Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer Sci. 2007 Jun;98(6):890-9.
• [108] Non-nutritional sweeteners effects on endothelial vascular function. Toxicol In Vitro. 2020 Feb;62:104694. doi: 10.1016/j.tiv.2019.104694. Epub 2019 Oct 23.
• [109] Regulation of epithelial cell morphology and functions approaching to more in vivo-like by modifying polyethylene glycol on polysulfone membranes. PLoS One. 2012;7(4):e36110.
• [110] Gene expression profile changes in NB4 cells induced by arsenic trioxide. Acta Pharmacol Sin. 2003 Jul;24(7):646-50.
• [111] Cannabidiol Modulates the Expression of Alzheimer's Disease-Related Genes in Mesenchymal Stem Cells. Int J Mol Sci. 2016 Dec 23;18(1):26. doi: 10.3390/ijms18010026.
• [112] Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity. Cell Biol Toxicol. 2021 Apr;37(2):151-175. doi: 10.1007/s10565-020-09537-1. Epub 2020 Jun 14.
• [113] K-RAS transformation in prostate epithelial cell overcomes H2O2-induced apoptosis via upregulation of gamma-glutamyltransferase-2. Toxicol In Vitro. 2012 Apr;26(3):429-34. doi: 10.1016/j.tiv.2012.01.013. Epub 2012 Jan 17.
• [114] Consequences of the natural retinoid/retinoid X receptor ligands action in human breast cancer MDA-MB-231 cell line: Focus on functional proteomics. Toxicol Lett. 2017 Nov 5;281:26-34. doi: 10.1016/j.toxlet.2017.09.001. Epub 2017 Sep 5.
• [115] High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities. Arch Toxicol. 2017 Mar;91(3):1367-1383. doi: 10.1007/s00204-016-1781-0. Epub 2016 Jun 29.
• [116] Enhanced GRP78 protein expression via the IRE1/ASK1/p38 MAPK pathway during As(2)O(3)-induced endoplasmic reticulum stress in BEAS-2B cells. Toxicology. 2021 Oct;462:152962. doi: 10.1016/j.tox.2021.152962. Epub 2021 Sep 21.
• [117] [Simvastatin-induced apoptosis of K562 cells is mediated by endoplasmic reticulum stress]. Yao Xue Xue Bao. 2008 Apr;43(4):371-7.
• [118] Chronic oxycodone induces integrated stress response in rat brain. BMC Neurosci. 2015 Sep 16;16:58. doi: 10.1186/s12868-015-0197-8.
• [119] Involvement of the activation of Nrf2/HO-1, p38 MAPK signaling pathways and endoplasmic reticulum stress in furazolidone induced cytotoxicity and S phase arrest in human hepatocyte L02 cells: modulation of curcumin. Toxicol Mech Methods. 2017 Mar;27(3):165-172. doi: 10.1080/15376516.2016.1273424. Epub 2017 Jan 8.
• [120] Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells. J Cell Biochem. 2006 Aug 1;98(5):1163-84.
• [121] Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
• [122] Protein expression profiling identifies molecular targets of quercetin as a major dietary flavonoid in human colon cancer cells. Proteomics. 2004 Jul;4(7):2160-74.
• [123] Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
• [124] Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
• [125] Glucosamine-induced endoplasmic reticulum stress promotes ApoB100 degradation: evidence for Grp78-mediated targeting to proteasomal degradation. Arterioscler Thromb Vasc Biol. 2005 Mar;25(3):571-7. doi: 10.1161/01.ATV.0000154142.61859.94. Epub 2004 Dec 23.
• [126] Inter-laboratory comparison of human renal proximal tubule (HK-2) transcriptome alterations due to Cyclosporine A exposure and medium exhaustion. Toxicol In Vitro. 2009 Apr;23(3):486-99.
• [127] Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
• [128] Cannabidiol Effectively Promoted Cell Death in Bladder Cancer and the Improved Intravesical Adhesion Drugs Delivery Strategy Could Be Better Used for Treatment. Pharmaceutics. 2021 Sep 7;13(9):1415. doi: 10.3390/pharmaceutics13091415.
• [129] Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
• [130] Inhibition of invasion and induction of apoptosis by selenium in human malignant brain tumour cells in vitro. Int J Oncol. 2007 May;30(5):1263-71.
• [131] Pentosan polysulfate decreases proliferation and extracellular matrix deposition by vascular smooth muscle cells isolated from failed hemodialysis access grafts. Clin Nephrol. 2000 Aug;54(2):121-7.
• [132] Peripheral blood expression of nuclear factor-kappab-regulated genes is associated with rheumatoid arthritis disease activity and responds differentially to anti-tumor necrosis factor-alpha versus methotrexate. J Rheumatol. 2007 Sep;34(9):1817-22. Epub 2007 Aug 1.
• [133] Matrix metalloproteinase-9 is involved in chronic lymphocytic leukemia cell response to fludarabine and arsenic trioxide. PLoS One. 2014 Jun 23;9(6):e99993. doi: 10.1371/journal.pone.0099993. eCollection 2014.
• [134] Simvastatin, an HMG-CoA reductase inhibitor, reduced the expression of matrix metalloproteinase-9 (Gelatinase B) in osteoblastic cells and HT1080 fibrosarcoma cells. J Pharmacol Sci. 2004 Apr;94(4):403-9. doi: 10.1254/jphs.94.403.
• [135] Cannabinoids synergize with carfilzomib, reducing multiple myeloma cells viability and migration. Oncotarget. 2016 Nov 22;7(47):77543-77557. doi: 10.18632/oncotarget.12721.
• [136] Hsa-let-7g miRNA regulates the anti-tumor effects of gastric cancer cells under oxidative stress through the expression of DDR genes. J Toxicol Sci. 2015 Jun;40(3):329-38. doi: 10.2131/jts.40.329.
• [137] Inhibition of cardiomyocyte differentiation of human induced pluripotent stem cells by Ribavirin: Implication for its cardiac developmental toxicity. Toxicology. 2020 Apr 15;435:152422. doi: 10.1016/j.tox.2020.152422. Epub 2020 Feb 26.
• [138] Synthesis and structure-activity relationships of new antiproliferative and proapoptotic retinoid-related biphenyl-4-yl-acrylic acids. Bioorg Med Chem. 2007 Jul 15;15(14):4863-75. doi: 10.1016/j.bmc.2007.04.057. Epub 2007 May 3.
• [139] Methotrexate induces apoptosis through p53/p21-dependent pathway and increases E-cadherin expression through downregulation of HDAC/EZH2. Biochem Pharmacol. 2011 Feb 15;81(4):510-7. doi: 10.1016/j.bcp.2010.11.014. Epub 2010 Nov 27.
• [140] Actinomycin D inhibits the expression of the cystine/glutamate transporter xCT via attenuation of CD133 synthesis in CD133(+) HCC. Chem Biol Interact. 2019 Aug 25;309:108713. doi: 10.1016/j.cbi.2019.06.026. Epub 2019 Jun 19.
• [141] Simvastatin and purine analogs have a synergic effect on apoptosis of chronic lymphocytic leukemia cells. Ann Hematol. 2010 Nov;89(11):1115-24. doi: 10.1007/s00277-010-0988-z. Epub 2010 May 25.
• [142] The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib. Toxicol Sci. 2023 Dec 21;197(1):69-78. doi: 10.1093/toxsci/kfad099.
• [143] The isoflavonoids genistein and quercetin activate different stress signaling pathways as shown by analysis of site-specific phosphorylation of ATM, p53 and histone H2AX. DNA Repair (Amst). 2004 Mar 4;3(3):235-44. doi: 10.1016/j.dnarep.2003.10.014.
• [144] Dexamethasone and the inflammatory response in explants of human omental adipose tissue. Mol Cell Endocrinol. 2010 Feb 5;315(1-2):292-8.
• [145] DNA array analysis of the effects of aspirin on colon cancer cells: involvement of Rac1. Carcinogenesis. 2004 Jul;25(7):1293-8.
• [146] Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
• [147] Identification of genes linked to gefitinib treatment in prostate cancer cell lines with or without resistance to androgen: a clue to application of gefitinib to hormone-resistant prostate cancer. Oncol Rep. 2006 Jun;15(6):1453-60.
• [148] The thioredoxin system mediates redox-induced cell death in human colon cancer cells: implications for the mechanism of action of anticancer agents. Cancer Res. 2008 Oct 15;68(20):8269-77. doi: 10.1158/0008-5472.CAN-08-2010.
• [149] Development of an alternative zebrafish model for drug-induced intestinal toxicity. J Appl Toxicol. 2018 Feb;38(2):259-273. doi: 10.1002/jat.3520. Epub 2017 Oct 13.
• [150] Response rate of fibrosarcoma cells to cytotoxic drugs on the expression level correlates to the therapeutic response rate of fibrosarcomas and is mediated by regulation of apoptotic pathways. BMC Cancer. 2005 Jul 7;5:74. doi: 10.1186/1471-2407-5-74.
• [151] Suppression of RAGE as a basis of simvastatin-dependent plaque stabilization in type 2 diabetes. Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2716-23.
• [152] Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells. Biol Pharm Bull. 2013;36(6):944-51. doi: 10.1248/bpb.b12-01004.
• [153] Rapamycin sensitizes multiple myeloma cells to apoptosis induced by dexamethasone. Blood. 2004 Apr 15;103(8):3138-47. doi: 10.1182/blood-2003-05-1543. Epub 2003 Dec 24.
• [154] Antidepressant drug sertraline modulates AMPK-MTOR signaling-mediated autophagy via targeting mitochondrial VDAC1 protein. Autophagy. 2021 Oct;17(10):2783-2799. doi: 10.1080/15548627.2020.1841953. Epub 2020 Nov 9.
• [155] EGFR tyrosine kinase inhibitors activate autophagy as a cytoprotective response in human lung cancer cells. PLoS One. 2011;6(6):e18691. doi: 10.1371/journal.pone.0018691. Epub 2011 Jun 2.
• [156] Oxidative stress induces parallel autophagy and mitochondria dysfunction in human glioma U251 cells. Toxicol Sci. 2009 Aug;110(2):376-88. doi: 10.1093/toxsci/kfp101. Epub 2009 May 18.
• [157] Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner. Clin Cancer Res. 2012 Aug 15;18(16):4345-55. doi: 10.1158/1078-0432.CCR-11-3227. Epub 2012 Jun 25.
• [158] Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105.
• [159] SU5416 inhibited VEGF and HIF-1alpha expression through the PI3K/AKT/p70S6K1 signaling pathway. Biochem Biophys Res Commun. 2004 Nov 12;324(2):471-80. doi: 10.1016/j.bbrc.2004.09.082.
• [160] D-glucosamine down-regulates HIF-1alpha through inhibition of protein translation in DU145 prostate cancer cells. Biochem Biophys Res Commun. 2009 Apr 24;382(1):96-101. doi: 10.1016/j.bbrc.2009.02.129. Epub 2009 Feb 28.
• [161] Arsenic trioxide inhibits translation of mRNA of bcr-abl, resulting in attenuation of Bcr-Abl levels and apoptosis of human leukemia cells. Cancer Res. 2003 Nov 15;63(22):7950-8.
• [162] Inhibiting Heat Shock Proteins Can Potentiate the Cytotoxic Effect of Cannabidiol in Human Glioma Cells. Anticancer Res. 2015 Nov;35(11):5827-37.
• [163] Induction of CCAAT/enhancer-binding protein-homologous protein by cigarette smoke through the superoxide anion-triggered PERK-eIF2 pathway. Toxicology. 2011 Sep 5;287(1-3):105-12. doi: 10.1016/j.tox.2011.06.005. Epub 2011 Jun 15.
• [164] Amiodarone sensitizes human glioma cells but not astrocytes to TRAIL-induced apoptosis via CHOP-mediated DR5 upregulation. Neuro Oncol. 2011 Mar;13(3):267-79. doi: 10.1093/neuonc/noq195. Epub 2011 Feb 3.
• [165] Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
• [166] Utilization of causal reasoning of hepatic gene expression in rats to identify molecular pathways of idiosyncratic drug-induced liver injury. Toxicol Sci. 2014 Jan;137(1):234-48. doi: 10.1093/toxsci/kft232. Epub 2013 Oct 17.
• [167] Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells. Eur J Pharmacol. 2014 Jun 5;732:60-7.
• [168] Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
• [169] Restoration by aspirin of impaired plasma maspin level in human breast cancer. Acta Oncol. 2006;45(2):184-7. doi: 10.1080/02841860500516584.
• [170] Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
• [171] Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
• [172] Effects of 5-Aza-CdR on cell proliferation of breast cancer cell line MDA-MB-435S and expression of maspin gene. J Huazhong Univ Sci Technolog Med Sci. 2007 Oct;27(5):543-6. doi: 10.1007/s11596-007-0517-z.
• [173] The thioxotriazole copper(II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cells. J Biol Chem. 2009 Sep 4;284(36):24306-19.
• [174] Different apoptosis ratios and gene expressions in two human cell lines after sevoflurane anaesthesia. Acta Anaesthesiol Scand. 2009 Oct;53(9):1192-9. doi: 10.1111/j.1399-6576.2009.02036.x. Epub 2009 Jun 30.
• [175] [Mechanisms underlying the effect of arsenic trioxide on proliferation inhibition and apoptosis induction in myeloma cell line u266]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2007 Oct;15(5):982-5.
• [176] Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPAR-dependent pathway. Oncotarget. 2016 Mar 1;7(9):10345-62. doi: 10.18632/oncotarget.7213.
• [177] Induction of apoptosis by cidofovir in human papillomavirus (HPV)-positive cells. Oncol Res. 2000;12(9-10):397-408. doi: 10.3727/096504001108747855.
• [178] Comparison of burst of reactive oxygen species and activation of caspase-3 in apoptosis of K562 and HL-60 cells induced by docetaxel. Cancer Lett. 2004 Oct 8;214(1):103-13. doi: 10.1016/j.canlet.2004.03.047.
• [179] Induction of mitochondrial manganese superoxide dismutase confers resistance to apoptosis in acute myeloblastic leukaemia cells exposed to etoposide. Br J Haematol. 2000 Mar;108(3):574-81. doi: 10.1046/j.1365-2141.2000.01852.x.
• [180] Cisplatin-enhanced sensitivity of glioblastoma multiforme U251 cells to adenovirus-delivered TRAIL in vitro. Tumour Biol. 2010 Dec;31(6):613-22. doi: 10.1007/s13277-010-0077-x. Epub 2010 Jul 11.
• [181] Insulin-like growth factor I is the key growth factor in serum that protects neuroblastoma cells from hyperosmotic-induced apoptosis. J Cell Physiol. 2000 Jan;182(1):24-32. doi: 10.1002/(SICI)1097-4652(200001)182:1<24::AID-JCP3>3.0.CO;2-6.
• [182] mRNA expression analysis of a variety of apoptosis-related genes, including the novel gene of the BCL2-family, BCL2L12, in HL-60 leukemia cells after treatment with carboplatin and doxorubicin. Biol Chem. 2004 Nov;385(11):1099-103. doi: 10.1515/BC.2004.143.
• [183] Neurokinin-1 receptor (NK1R) inhibition sensitizes APL cells to anti-tumor effect of arsenic trioxide via restriction of NF-B axis: Shedding new light on resistance to Aprepitant. Int J Biochem Cell Biol. 2018 Oct;103:105-114. doi: 10.1016/j.biocel.2018.08.010. Epub 2018 Aug 23.
• [184] Contrasting effects of fluoroquinolone antibiotics on the expression of the collagenases, matrix metalloproteinases (MMP)-1 and -13, in human tendon-derived cells. Rheumatology (Oxford). 2005 Dec;44(12):1514-7. doi: 10.1093/rheumatology/kei087. Epub 2005 Sep 7.
• [185] Chloramphenicol causes mitochondrial stress, decreases ATP biosynthesis, induces matrix metalloproteinase-13 expression, and solid-tumor cell invasion. Toxicol Sci. 2010 Jul;116(1):140-50. doi: 10.1093/toxsci/kfq085. Epub 2010 Mar 25.
• [186] Matrix metalloproteinases of epithelial origin in facial sebum of patients with acne and their regulation by isotretinoin. J Invest Dermatol. 2005 Oct;125(4):673-84. doi: 10.1111/j.0022-202X.2005.23848.x.
• [187] Glucosamine promotes chondrogenic phenotype in both chondrocytes and mesenchymal stem cells and inhibits MMP-13 expression and matrix degradation. Osteoarthritis Cartilage. 2007 Jun;15(6):646-55. doi: 10.1016/j.joca.2007.01.014. Epub 2007 Mar 6.
• [188] Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. Arch Toxicol. 2016 Jan;90(1):159-80.
• [189] Ouabain impairs cell migration, and invasion and alters gene expression of human osteosarcoma U-2 OS cells. Environ Toxicol. 2017 Nov;32(11):2400-2413. doi: 10.1002/tox.22453. Epub 2017 Aug 10.
• [190] Expression profiling in squamous carcinoma cells reveals pleiotropic effects of vitamin D3 analog EB1089 signaling on cell proliferation, differentiation, and immune system regulation. Mol Endocrinol. 2002 Jun;16(6):1243-56.
• [191] Retinoic acid-induced downmodulation of telomerase activity in human cancer cells. Exp Mol Pathol. 2005 Oct;79(2):108-17.
• [192] Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
• [193] Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029.
• [194] Cannabidiol Reduces Leukemic Cell Size - But Is It Important?. Front Pharmacol. 2017 Mar 24;8:144. doi: 10.3389/fphar.2017.00144. eCollection 2017.
• [195] Crizotinib-resistant mutants of EML4-ALK identified through an accelerated mutagenesis screen. Chem Biol Drug Des. 2011 Dec;78(6):999-1005. doi: 10.1111/j.1747-0285.2011.01239.x. Epub 2011 Oct 31.
• [196] Proteomics-based identification of differentially abundant proteins from human keratinocytes exposed to arsenic trioxide. J Proteomics Bioinform. 2014 Jul;7(7):166-178.
• [197] Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling. Aging (Albany NY). 2012 Dec;4(12):952-65. doi: 10.18632/aging.100521.
• [198] Androgen receptor-mTOR crosstalk is regulated by testosterone availability: implication for prostate cancer cell survival. Anticancer Res. 2010 Oct;30(10):3895-901.
• [199] Imatinib disturbs lysosomal function and morphology and impairs the activity of mTORC1 in human hepatocyte cell lines. Food Chem Toxicol. 2022 Apr;162:112869. doi: 10.1016/j.fct.2022.112869. Epub 2022 Feb 16.
• [200] Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine in bladder cancer cells. Oncogene. 2016 Aug 25;35(34):4518-28. doi: 10.1038/onc.2015.511. Epub 2016 Feb 8.
• [201] 4.8% sevoflurane induces activation of autophagy in human neuroblastoma SH-SY5Y cells by the AMPK/mTOR signaling pathway. Neurotoxicology. 2022 May;90:256-264. doi: 10.1016/j.neuro.2022.04.008. Epub 2022 Apr 23.
• [202] Verapamil potentiates anti-glioblastoma efficacy of temozolomide by modulating apoptotic signaling. Toxicol In Vitro. 2018 Oct;52:306-313. doi: 10.1016/j.tiv.2018.07.001. Epub 2018 Jul 9.
• [203] Effects of gonadotrophin-releasing hormone agonists on apoptosis of granulosa cells. Ann N Y Acad Sci. 2005 May;1042:531-7. doi: 10.1196/annals.1338.065.
• [204] BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile. J Biochem Mol Toxicol. 2019 May;33(5):e22286. doi: 10.1002/jbt.22286. Epub 2019 Jan 23.
• [205] Combining kallistatin gene therapy and meloxicam to treat hepatocellular carcinoma in mice. Cancer Sci. 2009 Nov;100(11):2226-33. doi: 10.1111/j.1349-7006.2009.01306.x. Epub 2009 Aug 4.
• [206] Comparison of the effects of metoclopramide and domperidone on HERG channels. Pharmacology. 2005 Apr;74(1):31-6. doi: 10.1159/000083234. Epub 2005 Jan 7.
• [207] Further insights into the effect of quinidine in short QT syndrome caused by a mutation in HERG. J Cardiovasc Electrophysiol. 2005 Jan;16(1):54-8. doi: 10.1046/j.1540-8167.2005.04470.x.
• [208] Automated tight seal electrophysiology for assessing the potential hERG liability of pharmaceutical compounds. Assay Drug Dev Technol. 2004 Oct;2(5):497-506. doi: 10.1089/adt.2004.2.497.
• [209] Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model. Toxicol Sci. 2013 Dec;136(2):581-94. doi: 10.1093/toxsci/kft205. Epub 2013 Sep 19.
• [210] Pharmacology of the short QT syndrome N588K-hERG K+ channel mutation: differential impact on selected class I and class III antiarrhythmic drugs. Br J Pharmacol. 2008 Nov;155(6):957-66. doi: 10.1038/bjp.2008.325. Epub 2008 Aug 25.
• [211] Comparison of HERG channel blocking effects of various beta-blockers-- implication for clinical strategy. Br J Pharmacol. 2006 Mar;147(6):642-52. doi: 10.1038/sj.bjp.0706508.
• [212] Inhibitory effects of the class III antiarrhythmic drug amiodarone on cloned HERG potassium channels. Naunyn Schmiedebergs Arch Pharmacol. 1999 Mar;359(3):212-9. doi: 10.1007/pl00005344.
• [213] Redox state dependency of HERGS631C channel pharmacology: relation to C-type inactivation. FEBS Lett. 2000 May 26;474(1):111-5. doi: 10.1016/s0014-5793(00)01586-6.
• [214] Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
• [215] Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
• [216] Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
• [217] Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
• [218] eNOS activation mediated by AMPK after stimulation of endothelial cells with histamine or thrombin is dependent on LKB1. Biochim Biophys Acta. 2011 Feb;1813(2):322-31. doi: 10.1016/j.bbamcr.2010.12.001. Epub 2010 Dec 9.
• [219] Effects of metformin and pioglitazone combination on apoptosis and AMPK/mTOR signaling pathway in human anaplastic thyroid cancer cells. J Biochem Mol Toxicol. 2020 Oct;34(10):e22547. doi: 10.1002/jbt.22547. Epub 2020 Jun 26.
• [220] Resveratrol activates duodenal Sirt1 to reverse insulin resistance in rats through a neuronal network. Nat Med. 2015 May;21(5):498-505. doi: 10.1038/nm.3821. Epub 2015 Apr 6.
• [221] Mutant p53 reactivation by PRIMA-1MET induces multiple signaling pathways converging on apoptosis. Oncogene. 2010 Mar 4;29(9):1329-38. doi: 10.1038/onc.2009.425. Epub 2009 Nov 30.
• [222] Phosphoinositide 3-kinase (PI3K) pathway alterations are associated with histologic subtypes and are predictive of sensitivity to PI3K inhibitors in lung cancer preclinical models. Clin Cancer Res. 2012 Dec 15;18(24):6771-83. doi: 10.1158/1078-0432.CCR-12-2347. Epub 2012 Nov 7.
• [223] Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018 Nov;121:214-223. doi: 10.1016/j.fct.2018.08.034. Epub 2018 Aug 26.
• [224] Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
• [225] A genomic approach to predict synergistic combinations for breast cancer treatment. Pharmacogenomics J. 2013 Feb;13(1):94-104. doi: 10.1038/tpj.2011.48. Epub 2011 Nov 15.
• [226] Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
• [227] Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies. J Biol Chem. 2019 Oct 18;294(42):15218-15234. doi: 10.1074/jbc.RA119.009147. Epub 2019 Jul 8.
• [228] Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
• [229] Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
• [230] Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens. Food Chem Toxicol. 2009 Apr;47(4):787-95.
• [231] Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
• [232] Targeting MYCN in neuroblastoma by BET bromodomain inhibition. Cancer Discov. 2013 Mar;3(3):308-23.
• [233] A trichostatin A expression signature identified by TempO-Seq targeted whole transcriptome profiling. PLoS One. 2017 May 25;12(5):e0178302. doi: 10.1371/journal.pone.0178302. eCollection 2017.
• [234] Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
• [235] Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
• [236] Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery. Mol Cancer. 2006 May 18;5:20. doi: 10.1186/1476-4598-5-20.
• [237] Epidermal growth factor receptor signalling in human breast cancer cells operates parallel to estrogen receptor alpha signalling and results in tamoxifen insensitive proliferation. BMC Cancer. 2014 Apr 23;14:283.
• [238] The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
• [239] Repression of Kisspeptin1 weakens hydrogen peroxide-caused injury in HTR8 cells via adjusting PI3K/AKT/mTOR pathway. J Biochem Mol Toxicol. 2020 May;34(5):e22461. doi: 10.1002/jbt.22461. Epub 2020 Feb 11.
• [240] Low Autophagy (ATG) Gene Expression Is Associated with an Immature AML Blast Cell Phenotype and Can Be Restored during AML Differentiation Therapy. Oxid Med Cell Longev. 2018 Mar 18;2018:1482795. doi: 10.1155/2018/1482795. eCollection 2018.
• [241] Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury. Arch Toxicol. 2020 Apr;94(4):1151-1172. doi: 10.1007/s00204-020-02691-9. Epub 2020 Mar 10.
• [242] Inhibitory effect of PXR on ammonia-induced hepatocyte autophagy via P53. Toxicol Lett. 2018 Oct 1;295:153-161. doi: 10.1016/j.toxlet.2018.06.1066. Epub 2018 Jun 14.
• [243] Arsenic trioxide induces autophagic cell death in osteosarcoma cells via the ROS-TFEB signaling pathway. Biochem Biophys Res Commun. 2018 Jan 29;496(1):167-175. doi: 10.1016/j.bbrc.2018.01.018. Epub 2018 Jan 4.
• [244] TNF enhances trovafloxacin-induced in vitro hepatotoxicity by inhibiting protective autophagy. Toxicol Lett. 2021 May 15;342:73-84. doi: 10.1016/j.toxlet.2021.02.009. Epub 2021 Feb 17.
• [245] Hydroquinone-induced endoplasmic reticulum stress affects TK6 cell autophagy and apoptosis via ATF6-mTOR. Environ Toxicol. 2023 Aug;38(8):1874-1890. doi: 10.1002/tox.23814. Epub 2023 May 6.
• [246] A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
• [247] From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
• [248] Bone marrow osteoblast damage by chemotherapeutic agents. PLoS One. 2012;7(2):e30758. doi: 10.1371/journal.pone.0030758. Epub 2012 Feb 17.
• [249] Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma. Oncotarget. 2014 May 15;5(9):2355-71.
• [250] New insights into BaP-induced toxicity: role of major metabolites in transcriptomics and contribution to hepatocarcinogenesis. Arch Toxicol. 2016 Jun;90(6):1449-58.
• [251] The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
• [252] 17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.
• [253] Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
• [254] Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92. doi: 10.1016/j.bbrc.2011.08.027. Epub 2011 Aug 16.
• [255] Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
• [256] Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
• [257] Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
• [258] LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
• [259] Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
• [260] Evidence for a role of claudin 2 as a proximal tubular stress responsive paracellular water channel. Toxicol Appl Pharmacol. 2014 Sep 1;279(2):163-72.
• [261] Drinking-water arsenic exposure modulates gene expression in human lymphocytes from a U.S. population. Environ Health Perspect. 2008 Apr;116(4):524-31. doi: 10.1289/ehp.10861.
• [262] Heterologous expression of the Na(+),K(+)-ATPase gamma subunit in Xenopus oocytes induces an endogenous, voltage-gated large diameter pore. J Physiol. 2001 Sep 1;535(Pt 2):407-17.
• [263] Cysteine mapping in conformationally distinct kinase nucleotide binding sites: application to the design of selective covalent inhibitors. J Med Chem. 2011 Mar 10;54(5):1347-55. doi: 10.1021/jm101396q. Epub 2011 Feb 15.
• [264] Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Cancer Res. 2006 Jun 1;66(11):5542-8. doi: 10.1158/0008-5472.CAN-05-4620.
• [265] Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 2004 May 20;350(21):2129-39. doi: 10.1056/NEJMoa040938. Epub 2004 Apr 29.
• [266] The dual ErbB1/ErbB2 inhibitor, lapatinib (GW572016), cooperates with tamoxifen to inhibit both cell proliferation- and estrogen-dependent gene expression in antiestrogen-resistant breast cancer. Cancer Res. 2005 Jan 1;65(1):18-25.
• [267] A fine-needle aspirate-based vulnerability assay identifies polo-like kinase 1 as a mediator of gemcitabine resistance in pancreatic cancer. Mol Cancer Ther. 2010 Feb;9(2):311-8. doi: 10.1158/1535-7163.MCT-09-0693. Epub 2010 Jan 26.
• [268] Prediction of chemosensitivity using multigene analysis in head and neck squamous cell carcinoma. Oncology. 2007;73(1-2):104-11. doi: 10.1159/000120998. Epub 2008 Mar 13.
• [269] Ligand-dependent activation of the epidermal growth factor receptor by secondary bile acids in polarizing colon cancer cells. Surgery. 2005 Sep;138(3):415-21. doi: 10.1016/j.surg.2005.06.030.
• [270] Selenium is critical for cancer-signaling gene expression but not cell proliferation in human colon Caco-2 cells. Biofactors. 2007;31(3-4):155-64. doi: 10.1002/biof.5520310302.
• [271] Plasma proteinase inhibitor activity and hemostasis tests in children with nephrotic syndrome. Effect of prednisone alone and prednisone plus epsilon-aminocaproic acid treatment regimens: a preliminary report. Am J Ther. 2001 Mar-Apr;8(2):97-107. doi: 10.1097/00045391-200103000-00004.
• [272] Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
• [273] Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells. Nat Commun. 2018 Aug 9;9(1):3069. doi: 10.1038/s41467-018-05402-2.
• [274] Proteomics analysis of the proliferative effect of low-dose ouabain on human endothelial cells. Biol Pharm Bull. 2007 Feb;30(2):247-53. doi: 10.1248/bpb.30.247.
• [275] Some HIV antiretrovirals increase oxidative stress and alter chemokine, cytokine or adiponectin production in human adipocytes and macrophages. Antivir Ther. 2007;12(4):489-500.
• [276] Additive beneficial cardiovascular and metabolic effects of combination therapy with ramipril and candesartan in hypertensive patients. Eur Heart J. 2007 Jun;28(12):1440-7. doi: 10.1093/eurheartj/ehm101. Epub 2007 May 5.
• [277] Adipogenic Effects and Gene Expression Profiling of Firemaster? 550 Components in Human Primary Preadipocytes. Environ Health Perspect. 2017 Sep 14;125(9):097013. doi: 10.1289/EHP1318.
• [278] Combination of an ACE inhibitor and indapamide improves blood pressure control, but attenuates the beneficial effects of ACE inhibition on plasma adiponectin in patients with essential hypertension. Circ J. 2009 Dec;73(12):2282-7. doi: 10.1253/circj.cj-09-0387. Epub 2009 Sep 29.
• [279] Role of PML SUMOylation in arsenic trioxide-induced fibrosis in HSCs. Life Sci. 2020 Jun 15;251:117607. doi: 10.1016/j.lfs.2020.117607. Epub 2020 Mar 30.
• [280] Effects of nevirapine and efavirenz on human adipocyte differentiation, gene expression, and release of adipokines and cytokines. Antiviral Res. 2011 Aug;91(2):112-9. doi: 10.1016/j.antiviral.2011.04.018. Epub 2011 May 17.
• [281] (9)-Tetrahydrocannabinol upregulates fatty acid 2-hydroxylase (FA2H) via PPAR induction: A possible evidence for the cancellation of PPAR/-mediated inhibition of PPAR in MDA-MB-231?cells. Arch Biochem Biophys. 2019 Feb 15;662:219-225. doi: 10.1016/j.abb.2018.12.011. Epub 2018 Dec 13.
• [282] Amino acid polymorphisms in the ATP-regulatable inward rectifier Kir6.2 and their relationships to glucose- and tolbutamide-induced insulin secretion, the insulin sensitivity index, and NIDDM. Diabetes. 1997 Mar;46(3):508-12. doi: 10.2337/diab.46.3.508.
• [283] The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
• [284] A receptor mechanism for the inhibition of insulin release by epinephrine in man. J Clin Invest. 1967 Jan;46(1):86-94. doi: 10.1172/JCI105514.
• [285] Vasodilatory effects of troglitazone improve blood pressure at rest and during mental stress in type 2 diabetes mellitus. Hypertension. 1999 Jul;34(1):83-8. doi: 10.1161/01.hyp.34.1.83.
• [286] Quinapril treatment restores the vasodilator action of insulin in fructose-hypertensive rats. Clin Exp Pharmacol Physiol. 2002 May-Jun;29(5-6):381-5. doi: 10.1046/j.1440-1681.2002.03668.x.
• [287] Retinoic acid can induce markers of endocrine transdifferentiation in pancreatic ductal adenocarcinoma: preliminary observations from an in vitro cell line model. J Clin Pathol. 2006 Jun;59(6):603-10. doi: 10.1136/jcp.2005.032003. Epub 2006 Feb 10.
• [288] Effects of prolonged in vitro exposure to sulphonylureas on the function and survival of human islets. J Diabetes Complications. 2005 Jan-Feb;19(1):60-4. doi: 10.1016/j.jdiacomp.2004.05.001.
• [289] Clonidine effect on insulin secretion and lipolysis in man. Acta Diabetol Lat. 1978 May-Aug;15(3-4):192-7. doi: 10.1007/BF02581064.
• [290] Beta-adrenergic contribution to glucagon-induced glucose production and insulin secretion in uremia. Am J Physiol. 1986 Sep;251(3 Pt 1):E322-7. doi: 10.1152/ajpendo.1986.251.3.E322.
• [291] Effect of testosterone replacement on whole body glucose utilisation and other cardiovascular risk factors in males with idiopathic hypogonadotrophic hypogonadism. Horm Metab Res. 1998 Oct;30(10):642-5. doi: 10.1055/s-2007-978950.