Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMU8ANS)

• Drug Name: Ximelegatran Drug Info
• Synonyms: Cyclohexanecarboxamide, 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-, trans-; y-27632; 146986-50-7; Y-27632 dihydrochloride; Y27632; UNII-0X370ROP6H; Y 27632; cyclohexanecarboxamide, 4-[(1R)-1-aminoethyl]-N-4-pyridinyl-, trans-; 0X370ROP6H; CHEBI:75393; 4-[(1R)-1-aminoethyl]-N-(pyridin-4-yl)cyclohexane-1-carboxamide; (R)-TRANS-4-(1-AMINOETHYL)-N-(4-PYRIDYL) CYCLOHEXANECARBOXAMIDE; 4-[(1R)-1-aminoethyl]-N-(4-pyridyl)cyclohexanecarboxamide; 4-[(1R)-1-aminoethyl]-N-pyridin-4-ylcyclohexane-1-carboxamide; (R)-(+)-trans-N-(4-pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide; Y-27632

Indication

Disease Entry	ICD 11	Status	REF
Myocardial infarction	BA41-BA43	Approved	[1]
Asthma	CA23	Terminated	[2]

• Cross-matching ID:
  PubChem CID: 448042
  ChEBI ID: CHEBI:75393
  CAS Number: CAS 146986-50-7
  TTD Drug ID: DMU8ANS
  VARIDT Drug ID: DR00750

Molecule-Related Drug Atlas

Drug(s) Targeting Rho-associated protein kinase (ROCK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Netarsudil	DM0LPI9	Open-angle glaucoma	9C61	Approved	[9]
Roclatan	DMVQ5X1	Glaucoma/ocular hypertension	9C61	Phase 3	[10]
AR-12286	DM5TC43	Glaucoma/ocular hypertension	9C61	Phase 2	[11]
AMA-76	DMBWNX5	Glaucoma/ocular hypertension	9C61	Phase 2	[12]
Cethrin	DMD3XMW	Spinal cord injury	ND51.2	Phase 1/2	[13]
Y-39983	DMXSEHF	Glaucoma/ocular hypertension	9C61	Phase 1/2	[14]
STM 434	DMDF29A	Ovarian cancer	2C73	Phase 1	[15]
AT13148	DMYIPKJ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[16]
Hexahydro azepinone derivative 1	DMC1ZIX	N. A.	N. A.	Patented	[15]
Isoquinoline sulfonyl derivative 2	DMT5E7M	N. A.	N. A.	Patented	[15]

Drug(s) Targeting Coagulation factor IIa (F2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Argatroban	DMFI46A	Thrombosis	DB61-GB90	Approved	[17]
Pyridoxal Phosphate	DMO2K0J	Malnutrition	5B50-5B71	Approved	[18]
Bivalirudin	DMECRX1	Thrombocytopenia	3B64	Approved	[19]
Dabigatran	DMDI6R4	Stroke	8B20	Approved	[20]
Desirudin Recombinant	DM2BTFN	Coagulation defect	3B10.0	Approved	[21]
Human prothrombin complex concentrate	DMPHVQ1	Bleeding disorder	GA20-GA21	Approved	[22]
Lepirudin	DM1I3D5	Thrombocytopenia	3B64	Approved	[23]
Anisindione	DM2C48U	Coagulation defect	3B10.0	Approved	[24]
ATryn antithrombin	DM79Y2T	Multiple sclerosis	8A40	Approved	[25]
Hirudin	DMYOC29	N. A.	N. A.	Phase 4	[26]

Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[27]
Selenium	DM25CGV	N. A.	N. A.	Approved	[28]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[29]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[30]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[33]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[34]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[35]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[36]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[37]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[38]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[39]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[40]
Selenium	DM25CGV	N. A.	N. A.	Approved	[28]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[41]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[42]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[43]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[44]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[45]

Drug(s) Affected By Rho-associated protein kinase 1 (ROCK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[46]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[49]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[50]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[51]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[54]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[55]

Drug(s) Affected By Ribosomal protein S6 kinase alpha-5 (RPS6KA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[54]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[62]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[63]

Drug(s) Affected By Ribosomal protein S6 kinase alpha-3 (RPS6KA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[64]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[67]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[67]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[54]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[68]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]

Drug(s) Affected By Serine/threonine-protein kinase N2 (PKN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[54]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[74]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[63]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[75]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[76]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[77]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[79]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[80]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[81]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[84]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[85]

Drug(s) Affected By Myosin-2 (MYH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[86]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[87]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[88]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[89]

Drug(s) Affected By Toll-like receptor 4 (TLR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[90]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[94]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[96]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[97]

Drug(s) Affected By High affinity copper uptake protein 1 (SLC31A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[75]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[33]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[99]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
TRIENTINE	DMD2WPG	Inborn error of metabolism	5C50-5C59	Approved	[98]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[54]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[100]

Drug(s) Affected By Retinoschisin (RS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[101]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[102]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[103]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[104]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[105]
Fructose	DM43AN2	Vomiting	MD90	Approved	[106]
Ketoprofen	DMRKXPT	Bursitis		Approved	[106]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[107]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[108]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[109]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[39]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[110]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[40]

Drug(s) Affected By Antileukoproteinase (SLPI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[111]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[111]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[112]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[111]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[111]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[111]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[111]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[111]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[111]

Drug(s) Affected By Thy-1 membrane glycoprotein (THY1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[114]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[115]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[63]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[116]
Bortezomib	DMNO38U	Leukemia		Approved	[117]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[118]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[121]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[90]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[122]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[123]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[124]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[125]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[126]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[128]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[129]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[130]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[131]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[132]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[133]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[135]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[136]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[137]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[138]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[139]

Drug(s) Affected By DNA excision repair protein ERCC-1 (ERCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[140]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[141]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[142]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[75]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[143]

Drug(s) Affected By Monocyte differentiation antigen CD14 (CD14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[64]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[58]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[145]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[146]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[147]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[67]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[60]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[149]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[150]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[152]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[153]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[154]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[111]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[155]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[156]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[111]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[157]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[158]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[159]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[160]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[106]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[161]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[162]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[163]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[108]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[164]

Drug(s) Affected By Integrin alpha-M (ITGAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[166]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[167]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[168]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[169]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[170]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[171]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[172]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[173]

Drug(s) Affected By Proliferating cell nuclear antigen (PCNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[161]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[174]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[175]
Selenium	DM25CGV	N. A.	N. A.	Approved	[176]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[177]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[178]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[179]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[180]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[181]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[182]

Drug(s) Affected By Sodium/potassium-transporting ATPase subunit beta-2 (ATP1B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[184]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[185]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[85]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[186]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[187]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[188]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[189]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[190]

Drug(s) Affected By Fatty acid-binding protein, adipocyte (FABP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[191]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[192]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[193]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[194]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[191]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[195]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[196]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[197]

Drug(s) Affected By Endoglin (ENG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[198]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[199]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[62]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[63]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[200]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[75]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[201]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[202]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[203]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[64]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[204]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[205]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[207]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[208]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[209]

Drug(s) Affected By Cyclin-A2 (CCNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[210]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[211]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[174]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[178]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[136]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[213]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[181]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[214]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]

Drug(s) Affected By Cofilin-1 (CFL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[175]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[215]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[216]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[217]
Haloperidol	DM96SE0	Delirium		Approved	[218]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[219]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[54]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[220]

Drug(s) Affected By DNA excision repair protein ERCC-5 (ERCC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[221]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[221]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[85]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[63]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[75]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[222]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[223]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[224]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[225]

Drug(s) Affected By Nitric oxide synthase 3 (NOS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[226]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[227]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[106]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[228]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[229]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[230]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[231]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[232]
Fructose	DM43AN2	Vomiting	MD90	Approved	[233]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[234]

Drug(s) Affected By G1/S-specific cyclin-D3 (CCND3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[235]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[236]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[139]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[237]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[238]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[239]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[240]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[198]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[203]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[94]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[241]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[242]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[164]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[243]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[244]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[245]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[177]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[246]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[247]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[248]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[249]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[192]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[250]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[251]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[252]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[253]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[254]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[255]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[56]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[256]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[257]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[133]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[258]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[259]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[260]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[261]

Drug(s) Affected By Proliferation marker protein Ki-67 (MKI67)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[262]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[213]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[263]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[264]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[240]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[265]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[266]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[94]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[267]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[268]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[269]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[270]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[271]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[272]
Fructose	DM43AN2	Vomiting	MD90	Approved	[273]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[274]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[275]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[276]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[277]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[77]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[278]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[279]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[43]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[272]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[280]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[281]

Drug(s) Affected By LIM domain kinase 1 (LIMK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[282]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[75]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[283]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[284]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[285]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[286]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[287]

Drug(s) Affected By Solute carrier family 12 member 2 (SLC12A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[112]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[48]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[288]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[289]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[290]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[54]
Furosemide	DMMQ8ZG	Congestive heart failure	BD10	Approved	[289]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[288]

Drug(s) Affected By Transforming protein RhoA (RHOA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[210]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[180]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[291]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[292]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[293]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[293]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[145]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[294]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[52]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[295]

Drug(s) Affected By Myosin regulatory light chain 2, atrial isoform (MYL7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[296]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[67]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[297]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[201]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[298]
Phenylephrine	DMZHUO5	Allergic rhinitis	CA08.0	Approved	[299]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[300]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[184]

Drug(s) Affected By Dystonin (DST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[267]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[85]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[301]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[302]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[54]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[74]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[113]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[164]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[303]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[208]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[304]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[305]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[306]

Drug(s) Affected By Bcl-2-interacting killer (BIK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[307]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[308]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[309]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[310]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[311]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[312]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[301]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[313]

Drug(s) Affected By CD166 antigen (ALCAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[113]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[33]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[85]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[314]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[301]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[54]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[63]

Drug(s) Affected By Runt-related transcription factor 2 (RUNX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[315]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[316]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[317]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[318]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[319]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[198]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[320]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[59]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[97]

Drug(s) Affected By Laminin subunit alpha-3 (LAMA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[293]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[293]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[198]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[97]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[114]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[97]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[97]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[97]

Drug(s) Affected By Nuclear receptor subfamily 4 group A member 3 (NR4A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[106]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[321]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[321]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[322]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[312]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[200]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[321]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[323]

Drug(s) Affected By ATP-binding cassette sub-family C member 2 (ABCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lopinavir	DMITQS0	Human immunodeficiency virus infection	1C62	Approved	[324]
Sulfinpyrazone	DMEV954	Gout	FA25	Approved	[325]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[326]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[327]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[328]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[329]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[330]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[331]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[100]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[332]

Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[333]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[334]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[113]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[335]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[336]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[337]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[338]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[340]

Drug(s) Affected By Collagen alpha-1(XVII) chain (COL17A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[293]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[293]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[114]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[63]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[293]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[341]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[342]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[343]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[344]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[345]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Coagulation factor IIa (F2)	TT6L509	THRB_HUMAN	Inhibitor	[1]
Rho-associated protein kinase (ROCK)	TTMQO60	NOUNIPROTAC	Modulator	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[4]
Antileukoproteinase (SLPI)	OTUNFUU8	SLPI_HUMAN	Gene/Protein Processing	[5]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[6]
ATP-binding cassette sub-family C member 2 (ABCC2)	OTJSIGV5	MRP2_HUMAN	Gene/Protein Processing	[6]
Bcl-2-interacting killer (BIK)	OTTH1T3D	BIK_HUMAN	Gene/Protein Processing	[6]
Bcl2-associated agonist of cell death (BAD)	OT63ERYM	BAD_HUMAN	Gene/Protein Processing	[6]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Gene/Protein Processing	[7]
CD166 antigen (ALCAM)	OTCO4LP7	CD166_HUMAN	Gene/Protein Processing	[5]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Gene/Protein Processing	[6]
Cofilin-1 (CFL1)	OTT6D5MH	COF1_HUMAN	Gene/Protein Processing	[8]

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