Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM6AVR4)

• Drug Name: Hydroquinone Drug Info
• Synonyms: hydroquinone; 1,4-benzenediol; Benzene-1,4-diol; 123-31-9; 1,4-Dihydroxybenzene; Quinol; p-Benzenediol; p-Hydroxyphenol; p-Hydroquinone; 4-Hydroxyphenol; Eldoquin; Benzoquinol; p-Dihydroxybenzene; hydroquinol; Eldopaque; Phiaquin; p-Dioxybenzene; Hydroquinole; Dihydroquinone; Tecquinol; Idrochinone; Benzohydroquinone; Tequinol; Hidroquinone; Arctuvin; Dihydroxybenzene; Solaquin forte; Derma-Blanch; Tenox HQ; Hydrochinone; Hydrochinon; Artra; Eldoquin Forte; Eldopaque Forte; Diak 5; Benzene, p-dihydroxy-; 1,4-Dihydroxy-benzol; Usaf ek-356; Accutin

Indication

Disease Entry	ICD 11	Status	REF
Melasma	ED60.1	Approved	[1]

• Cross-matching ID:
  PubChem CID: 785
  ChEBI ID: CHEBI:17594
  CAS Number: CAS 123-31-9
  TTD Drug ID: DM6AVR4
  INTEDE Drug ID: DR0835

Molecule-Related Drug Atlas

Drug(s) Targeting Glycoprotein IIb/IIIa receptor (GPIIb/IIIa)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eptifibatide	DMQXTJS	Acute cardiac ischemic events	BA40.Z	Approved	[11]
Tirofiban	DMQG17S	Acute coronary syndrome	BA41	Approved	[12]
Abciximab	DMJO6GV	Acute disease		Approved	[12]
DMP-444	DMO7BQS	Coronary artery disease	BA80	Phase 3	[13]
99mTc-rBitistatin	DMFAMNH	Pulmonary embolism	JB42	Phase 1/2	[14]
AjvW2	DM6PN4H	Thrombosis	DB61-GB90	Phase 1	[15]
SDZ-GPI-562	DMU9ZGN	Thrombosis	DB61-GB90	Phase 1	[16]
RGD-891	DMVJMF1	Thrombosis	DB61-GB90	Phase 1	[17]
Lefradafiban	DMKZVLH	Angina pectoris	BA40	Phase 1	[18]
XEMILOFIBAN	DMBRYT8	Cardiovascular disease	BA00-BE2Z	Discontinued in Phase 3	[19]

Drug(s) Targeting Tyrosinase (TYR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Monobenzone	DMVJS2K	Vitiligo	ED63.0	Approved	[3]
Multi-epitope peptide melanoma vaccine	DMZPEHY	Melanoma	2C30	Phase 3	[20]
Melanoma vaccine	DMQEC6Z	Melanoma	2C30	Phase 3	[21]
Polynoma-1	DM3QDA6	Melanoma	2C30	Phase 2	[22]
MKC-1106-MT	DMXKOW6	Melanoma	2C30	Phase 2	[23]
Multi-epitope tyrosinase/gp100 vaccine	DMN68ZL	Melanoma	2C30	Phase 2	[24]
PMID29130358-Compound-Figure11(3)	DMSME2B	N. A.	N. A.	Patented	[25]
Benzothiazole analog 1	DMHXFCQ	Albinism	EC23.2	Patented	[26]
Monoamine derivative 2	DMAZ6DI	Albinism	EC23.2	Patented	[26]
Benzimidazole derivative 3	DMY93WG	Albinism	EC23.2	Patented	[26]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[27]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[28]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[29]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[30]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[31]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[33]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[34]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[28]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[35]

Drug(s) Metabolized By Fumarate reductase flavoprotein (frdA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fumarate	DM9VLS2	Discovery agent	N.A.	Investigative	[5]

Drug(s) Affected By CCN family member 1 (CCN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[36]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[37]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[45]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[46]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[48]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Selenium	DM25CGV	N. A.	N. A.	Approved	[50]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[45]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[51]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[51]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 12 (TNFSF12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[55]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[56]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[60]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[61]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[62]

Drug(s) Affected By ATP-dependent DNA helicase Q4 (RECQL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Bortezomib	DMNO38U	Leukemia		Approved	[65]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[69]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[70]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[71]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[70]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[72]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[74]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[75]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[76]

Drug(s) Affected By Fibronectin (FN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[77]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[80]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[82]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[83]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[85]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[86]

Drug(s) Affected By Ferritin heavy chain (FTH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[87]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[88]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[89]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[91]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[92]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]

Drug(s) Affected By Aldehyde dehydrogenase, mitochondrial (ALDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[96]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[97]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[101]

Drug(s) Affected By Microsomal glutathione S-transferase 1 (MGST1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[106]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[108]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[71]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[48]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[110]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[111]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[112]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[113]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[114]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[115]

Drug(s) Affected By DnaJ homolog subfamily B member 1 (DNAJB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[116]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[118]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[119]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[120]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[113]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[121]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[122]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]

Drug(s) Affected By DnaJ homolog subfamily A member 1 (DNAJA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[125]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[116]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[126]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[128]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[129]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[130]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[131]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[132]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[133]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[134]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[135]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[136]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[137]

Drug(s) Affected By Death-associated protein 1 (DAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[55]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[139]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[140]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[141]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[142]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]

Drug(s) Affected By Matrix metalloproteinase-15 (MMP15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[72]
Selenium	DM25CGV	N. A.	N. A.	Approved	[144]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[145]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[148]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[149]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[150]

Drug(s) Affected By Heat shock-related 70 kDa protein 2 (HSPA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[152]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[153]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[154]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[155]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[156]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[157]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[158]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[159]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[160]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[161]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[162]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[163]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[164]

Drug(s) Affected By Caspase-6 (CASP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[165]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[166]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[167]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[168]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[169]

Drug(s) Affected By Peroxiredoxin-1 (PRDX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[171]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[145]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[172]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[125]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[173]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[174]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]

Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[120]
Quinolones	DM5GVHU	Bacterial infection	1A00-1C4Z	Approved	[175]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[176]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]

Drug(s) Affected By FAS-associated death domain protein (FADD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Selenium	DM25CGV	N. A.	N. A.	Approved	[177]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[178]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[160]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[172]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[120]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[179]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[180]
Acitretin	DM8BKU9	Psoriasis vulgaris	EA90	Approved	[181]

Drug(s) Affected By Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[182]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[55]
Hesperidin	DMI5DW1	Vascular purpura	3B60	Approved	[184]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[185]

Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[186]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[137]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[187]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[188]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[190]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[192]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 25 (TNFRSF25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[145]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[192]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[55]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[194]
Hesperidin	DMI5DW1	Vascular purpura	3B60	Approved	[184]

Drug(s) Affected By TNF receptor-associated factor 4 (TRAF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[195]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[196]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[55]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[197]
Haloperidol	DM96SE0	Delirium		Approved	[198]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[199]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[200]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[201]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[202]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[203]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[204]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[206]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[207]
Selenium	DM25CGV	N. A.	N. A.	Approved	[208]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[209]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[210]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[211]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[172]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[212]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]

Drug(s) Affected By C-C motif chemokine 3 (CCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[213]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[125]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[153]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[215]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[216]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[216]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[213]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[216]

Drug(s) Affected By C-C motif chemokine 4 (CCL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[125]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[153]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[92]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[216]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[216]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[218]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[216]

Drug(s) Affected By C-C motif chemokine 5 (CCL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[200]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[219]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[220]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[221]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[222]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[223]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[216]

Drug(s) Affected By Eotaxin (CCL11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[224]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[225]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[226]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[227]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Tacrolimus	DMZ7XNQ	Graft-versus-host disease	4B24	Approved	[229]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[230]

Drug(s) Affected By DNA-dependent protein kinase catalytic subunit (PRKDC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[231]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[232]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[233]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[120]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[180]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[218]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]

Drug(s) Affected By Glutathione synthetase (GSS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[234]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[235]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[236]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[237]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[238]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[237]

Drug(s) Affected By Protein phosphatase 1D (PPM1D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[231]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[36]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[161]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[45]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[239]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]

Drug(s) Affected By Stanniocalcin-2 (STC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[240]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[241]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[242]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]

Drug(s) Affected By G1/S-specific cyclin-E2 (CCNE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[243]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[244]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[45]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[245]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[246]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[247]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[93]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[248]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[249]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[250]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[251]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[252]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[125]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[253]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[126]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[254]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[255]

Drug(s) Affected By Histone H2A type 1 (H2AC11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[83]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[256]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[218]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[257]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]

Drug(s) Affected By Histone H1.4 (H1-4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[258]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[124]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[259]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[260]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[261]

Drug(s) Affected By Histone H1.5 (H1-5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[262]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[263]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[264]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[256]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[258]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]

Drug(s) Affected By Histone H1.3 (H1-3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[265]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[266]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[267]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[268]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[259]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[217]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[269]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[71]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[270]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[234]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[110]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[165]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[271]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[272]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[273]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[274]

Drug(s) Affected By High mobility group protein B2 (HMGB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[69]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[232]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[91]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[275]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[71]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[48]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[276]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[36]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[277]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[278]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[263]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[247]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[69]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[200]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[279]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[280]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[36]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[281]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[282]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[283]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[45]

Drug(s) Affected By Cyclin-F (CCNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[245]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[284]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[285]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]

Drug(s) Affected By Histone H3-like centromeric protein A (CENPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[231]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[36]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]

Drug(s) Affected By Sestrin-2 (SESN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[201]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[263]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[119]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[120]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]

Drug(s) Affected By Histone H4 (H4C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[36]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[110]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[286]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[287]

Drug(s) Affected By Histone H3.1 (H3C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[263]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[241]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]

Drug(s) Affected By Protein BTG2 (BTG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[36]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[45]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[288]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[289]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[284]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[92]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]

Drug(s) Affected By ETS-related transcription factor Elf-3 (ELF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[290]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[218]

Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[249]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[36]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[292]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[293]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[294]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[295]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[296]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[297]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[298]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[299]

Drug(s) Affected By Histone H2A type 2-C (H2AC20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[300]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[152]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[301]
Haloperidol	DM96SE0	Delirium		Approved	[300]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[300]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[300]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[124]

Drug(s) Affected By Cell division cycle-associated protein 2 (CDCA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[120]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[302]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[218]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[120]

Drug(s) Affected By Histone H2A type 2-A (H2AC18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[303]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[124]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[304]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[305]

Drug(s) Affected By Proline/serine-rich coiled-coil protein 1 (PSRC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[306]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[65]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[307]

Drug(s) Affected By Protein aurora borealis (BORA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[69]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[306]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[258]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[307]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[308]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]

Drug(s) Affected By Protein mono-ADP-ribosyltransferase TIPARP (TIPARP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[93]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]

Drug(s) Affected By Histone H2A type 2-B (H2AC21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[258]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[259]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[309]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[310]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[311]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[312]

Drug(s) Affected By Tripartite motif-containing protein 59 (TRIM59)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[261]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[313]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[310]

Drug(s) Affected By Holliday junction recognition protein (HJURP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[302]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[306]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[258]
Methamphetamine	DMPM4SK	Anxiety		Approved	[315]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[316]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[304]

Drug(s) Affected By Kinesin-like protein KIF18A (KIF18A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[307]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]

Drug(s) Affected By Apoptosis-enhancing nuclease (AEN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[317]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[318]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[142]

Drug(s) Affected By Tumor protein p53-inducible nuclear protein 1 (TP53INP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[319]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[93]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[93]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[93]

Drug(s) Affected By Histone H2A type 1-H (H2AC12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[320]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[321]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[267]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[322]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[323]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[259]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[324]

Drug(s) Affected By Centriolar and ciliogenesis-associated protein HYLS1 (HYLS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[218]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[325]

Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[161]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[110]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[326]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[327]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[38]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[153]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[328]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[329]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[330]

Drug(s) Affected By Histone H2A type 1-J (H2AC14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[108]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[259]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[324]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[331]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[310]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[332]

Drug(s) Affected By Growth/differentiation factor 15 (GDF15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[36]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[45]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[333]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[334]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[334]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[335]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[336]

Drug(s) Affected By Protein FAM83D (FAM83D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[306]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[337]

Drug(s) Affected By DNA damage-inducible transcript 4 protein (DDIT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[262]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[45]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[338]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[339]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[120]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[287]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[218]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[340]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[55]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]

Drug(s) Affected By F-box only protein 5 (FBXO5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[244]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[218]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[306]

Drug(s) Affected By Sestrin-1 (SESN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[201]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[45]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[287]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[122]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]

Drug(s) Affected By Transcription regulator protein BACH1 (BACH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[87]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[341]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[342]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[120]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[343]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[120]

Drug(s) Affected By Cytochrome P450 2E1 (CYP2E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fomepizole	DM6VOWQ	Athylene glycol or methanol poisoning	NE61	Approved	[344]
Ademetionine	DMYQDBO	Hepatic fibrosis	DB93.0	Approved	[345]
Theophylline	DMRJFN9	Bronchitis	CA20	Approved	[198]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[346]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[347]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[348]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[349]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Didanosine	DMI2QPE	Human immunodeficiency virus infection	1C62	Approved	[198]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[350]

Drug(s) Affected By Death-associated protein-like 1 (DAPL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[351]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[312]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[352]

Drug(s) Affected By Killer cell lectin-like receptor subfamily G member 2 (KLRG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[351]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[353]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[291]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[352]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[265]

Drug(s) Affected By Rho GTPase-activating protein 42 (ARHGAP42)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[354]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[305]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[313]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[291]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[310]

Drug(s) Affected By Leucine-rich repeat and IQ domain-containing protein 3 (LRRIQ3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[94]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[311]
2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE	DMNQL17	Discovery agent	N.A.	Investigative	[355]

Drug(s) Affected By Cysteine-rich tail protein 1 (CYSRT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[356]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[313]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[310]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[356]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[312]

Drug(s) Affected By Rab GTPase-activating protein 1-like, isoform 10 (RABGAP1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[357]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[358]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[265]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[155]

Drug(s) Affected By Thymidine kinase 2, mitochondrial (TK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[359]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[360]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[361]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[305]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[362]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[363]

Drug(s) Affected By Unconventional myosin-If (MYO1F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[303]
Coprexa	DMA0WEK	Neurological disorder	6B60	Phase 3	[364]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[365]

Drug(s) Affected By Eukaryotic elongation factor 2 kinase (EEF2K)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[235]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[304]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[305]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[318]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[127]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[366]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]

Drug(s) Affected By Interferon-related developmental regulator 1 (IFRD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[231]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[119]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[367]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[235]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[39]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]

Drug(s) Affected By Butyrophilin subfamily 3 member A3 (BTN3A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[290]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[368]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[369]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[370]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[305]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[371]

Drug(s) Affected By Golgi SNAP receptor complex member 2 (GOSR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[372]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[148]
Bortezomib	DMNO38U	Leukemia		Approved	[65]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[261]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[127]

Drug(s) Affected By Putative transcription factor Ovo-like 1 (OVOL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[124]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[373]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[374]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[265]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 11 (TNFSF11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[375]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[376]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[377]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[378]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[379]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[378]

Drug(s) Affected By Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[380]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[37]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[381]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[382]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[218]

Drug(s) Affected By Proepiregulin (EREG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[243]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[383]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[383]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[383]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[384]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[383]

Drug(s) Affected By Inositol polyphosphate 4-phosphatase type II (INPP4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[290]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[83]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[218]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[304]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[385]

Drug(s) Affected By E3 ubiquitin-protein ligase Midline-1 (MID1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[372]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[386]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[387]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]

Drug(s) Affected By Monocarboxylate transporter 7 (SLC16A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[359]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[120]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[388]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[93]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]

Drug(s) Affected By ATP-binding cassette sub-family C member 3 (ABCC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[389]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[390]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[391]
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[392]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[87]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[72]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[393]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[394]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[395]

Drug(s) Affected By Toll-like receptor 3 (TLR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[145]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[290]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[242]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[381]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[396]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[397]

Drug(s) Affected By CASP8 and FADD-like apoptosis regulator (CFLAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[199]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[398]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[399]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[400]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[401]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[402]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[403]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[404]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[405]

Drug(s) Affected By Lysine-specific demethylase 6A (KDM6A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[381]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[261]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[406]

Drug(s) Affected By Mitotic checkpoint protein BUB3 (BUB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[218]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[407]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[408]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[325]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[268]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[409]

Drug(s) Affected By Calcineurin B homologous protein 2 (CHP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[372]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[410]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[291]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[352]

Drug(s) Affected By Aldo-keto reductase family 1 member B10 (AKR1B10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[411]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[412]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[413]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[414]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[415]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[416]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]

Drug(s) Affected By Serine protease inhibitor Kazal-type 4 (SPINK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[417]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[418]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[419]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[420]
Octanal	DMTN0OK	N. A.	N. A.	Investigative	[421]

Drug(s) Affected By Calcium-transporting ATPase type 2C member 2 (ATP2C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[291]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[312]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[422]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[265]

Drug(s) Affected By Arachidonate 12-lipoxygenase, 12R-type (ALOX12B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[211]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[423]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[423]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[312]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[352]

Drug(s) Affected By Jerky protein homolog (JRK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[351]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[267]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[313]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[366]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[424]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[425]

Drug(s) Affected By PR domain zinc finger protein 1 (PRDM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[92]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[93]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[93]
Ibrutinib	DMHZCPO	Mantle cell lymphoma	2A85.5	Approved	[426]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[71]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[263]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[287]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[121]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[92]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[93]

Drug(s) Affected By Krueppel-like factor 7 (KLF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[65]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Morphine	DMRMS0L	Advanced cancer	2A00-2F9Z	Approved	[427]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[313]
Fenretinide	DMRD5SP	Macular degeneration	9B78.3	Phase 3	[428]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[309]

Drug(s) Affected By DNA fragmentation factor subunit beta (DFFB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[429]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[120]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]

Drug(s) Affected By N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (DDAH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[108]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[430]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]

Drug(s) Affected By Extracellular matrix protein 2 (ECM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[348]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[431]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[261]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[312]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[218]

Drug(s) Affected By Protein transport protein Sec24D (SEC24D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[267]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[432]

Drug(s) Affected By Protein FAM13A (FAM13A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[218]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[321]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[433]
Vandetanib	DMRICNP	Solid tumour/cancer	2A00-2F9Z	Approved	[434]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[435]

Drug(s) Affected By Olfactory receptor 2C1 (OR2C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]

Drug(s) Affected By Interleukin-33 (IL33)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[369]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[351]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[436]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[437]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[438]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[439]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[440]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[441]

Drug(s) Affected By Caveolae-associated protein 2 (CAVIN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[240]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[241]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[307]

Drug(s) Affected By Chloride intracellular channel protein 3 (CLIC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[290]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[39]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[325]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[442]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[406]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[313]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[261]

Drug(s) Affected By Reversion-inducing cysteine-rich protein with Kazal motifs (RECK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[443]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[444]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[258]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[307]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]

Drug(s) Affected By Cholesterol 25-hydroxylase (CH25H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[235]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[108]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[387]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[419]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[445]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[123]

Drug(s) Affected By 2'-5'-oligoadenylate synthase 1 (OAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[246]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[37]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[83]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[336]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[446]

Drug(s) Affected By Serine protease inhibitor Kazal-type 1 (SPINK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[447]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[413]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[448]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[124]

Drug(s) Affected By Interleukin-1 alpha (IL1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[383]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[383]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[449]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[383]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[402]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[383]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[125]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[450]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[118]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[383]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[201]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[383]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[451]
Selenium	DM25CGV	N. A.	N. A.	Approved	[208]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[452]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[453]

Drug(s) Affected By Estrogen receptor (ESR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[454]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[455]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[456]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[457]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[458]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[459]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[460]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[461]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[457]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[462]

Drug(s) Affected By Interstitial collagenase (MMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[243]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[463]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[464]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[465]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[145]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[466]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[467]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[468]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[469]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]

Drug(s) Affected By Annexin A1 (ANXA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[470]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[211]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[290]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[287]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[92]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[471]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[211]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]

Drug(s) Affected By Arginase-1 (ARG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[472]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[39]

Drug(s) Affected By Ubiquitin-like protein ISG15 (ISG15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[37]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[271]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[473]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[381]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[382]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]

Drug(s) Affected By Endothelin-1 (EDN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[474]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[475]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[145]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[476]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[477]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[478]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[479]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[480]

Drug(s) Affected By Neuroendocrine protein 7B2 (SCG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[481]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[348]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[419]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[127]

Drug(s) Affected By Collagen alpha-2(V) chain (COL5A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[83]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[381]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[482]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[108]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[483]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[124]

Drug(s) Affected By Glia-derived nexin (SERPINE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]

Drug(s) Affected By Carbonic anhydrase 3 (CA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[291]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[419]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[331]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[365]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[265]
BICARBONATE	DMT5E36	Discovery agent	N.A.	Investigative	[484]

Drug(s) Affected By Asparagine synthetase (ASNS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[485]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[231]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[485]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[110]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[486]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[485]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]

Drug(s) Affected By Stromelysin-1 (MMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[198]
Fluvastatin	DM4MDJY	Arteriosclerosis	BD40	Approved	[198]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[198]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[198]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[240]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[465]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[487]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[488]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[468]

Drug(s) Affected By Inhibin beta A chain (INHBA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[489]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[490]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[108]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[435]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[491]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[325]

Drug(s) Affected By Keratin, type I cytoskeletal 19 (KRT19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[199]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[240]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[334]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[334]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[241]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[369]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]

Drug(s) Affected By Interferon alpha-inducible protein 6 (IFI6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[492]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[270]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[262]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[493]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[37]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[369]

Drug(s) Affected By Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[37]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[256]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[494]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[495]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[496]

Drug(s) Affected By Calcitonin gene-related peptide 2 (CALCB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[497]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[498]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[325]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[261]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[499]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[123]

Drug(s) Affected By Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial (DBT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[361]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[348]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[361]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[500]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[424]

Drug(s) Affected By Glycogen phosphorylase, brain form (PYGB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[501]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[313]

Drug(s) Affected By Serine/threonine-protein kinase pim-1 (PIM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[450]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[502]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[284]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[503]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]

Drug(s) Affected By C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[504]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[504]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[124]

Drug(s) Affected By Neurofilament heavy polypeptide (NEFH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[505]
Scopolamine	DMOM8AL	Addictive disorder	6C50-6C5Z	Approved	[506]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[507]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[267]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[508]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[509]

Drug(s) Affected By Annexin A3 (ANXA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[211]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[211]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]

Drug(s) Affected By Protein L-Myc (MYCL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[148]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[510]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[313]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[495]

Drug(s) Affected By Interferon-induced transmembrane protein 1 (IFITM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[511]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[83]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[369]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[382]

Drug(s) Affected By Keratin, type I cytoskeletal 13 (KRT13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[38]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[512]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[513]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[154]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[266]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[510]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[514]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[515]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[61]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]

Drug(s) Affected By Sodium/glucose cotransporter 1 (SLC5A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[87]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[516]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[435]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[406]
3,4-Dihydroxycinnamic Acid	DMVZL26	Thrombocytopenia	3B64	Phase 4	[517]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[518]
CERC-801	DM3SZ7P	N. A.	N. A.	Phase 2	[519]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[310]

Drug(s) Affected By Nidogen-1 (NID1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[520]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[372]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[521]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[108]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[522]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]

Drug(s) Affected By Glutamine synthetase (GLUL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[334]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[334]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[493]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[235]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[340]
Promegestone	DMK4S8I	Gynecological disease	GA6Z	Approved	[523]

Drug(s) Affected By Fos-related antigen 1 (FOSL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[240]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[113]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[284]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[524]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[525]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[122]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[93]

Drug(s) Affected By Transcription factor 4 (TCF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[526]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[527]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[526]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[381]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[528]
Bortezomib	DMNO38U	Leukemia		Approved	[529]

Drug(s) Affected By Aspartate aminotransferase, cytoplasmic (GOT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[530]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[93]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[531]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[93]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[93]

Drug(s) Affected By Insulin-like growth factor-binding protein 3 (IGFBP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Selenium	DM25CGV	N. A.	N. A.	Approved	[532]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[338]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[189]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[334]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[533]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[534]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[535]

Drug(s) Affected By Polyunsaturated fatty acid lipoxygenase ALOX12 (ALOX12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[536]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[537]
Masoprocol	DMMVNZ0	Prostate cancer	2C82.0	Approved	[536]
Bortezomib	DMNO38U	Leukemia		Approved	[538]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[536]
BAICALEIN	DM4C7E6	Influenza virus infection	1E30-1E32	Phase 2	[536]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[539]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[312]

Drug(s) Affected By Glutathione peroxidase 2 (GPX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[87]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[36]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[412]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[172]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[413]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[540]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[541]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[113]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[36]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[110]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[542]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[38]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[543]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[413]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[120]

Drug(s) Affected By Neutrophil cytosol factor 2 (NCF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[544]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[218]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[545]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[307]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]

Drug(s) Affected By Elafin (PI3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[413]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[546]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[430]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[419]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[547]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]

Drug(s) Affected By Ras-related protein Rab-3B (RAB3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[548]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[549]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[550]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[551]

Drug(s) Affected By Interferon-induced GTP-binding protein Mx1 (MX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[37]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[473]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[138]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[446]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[381]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[382]

Drug(s) Affected By Endothelin-2 (EDN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[552]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[483]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[553]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[554]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[348]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[94]

Drug(s) Affected By 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3 (FUT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[444]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[555]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[318]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[556]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[318]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]

Drug(s) Affected By Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[246]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[124]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[557]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[362]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[353]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[313]

Drug(s) Affected By Fibroblast growth factor receptor 3 (FGFR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[290]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[83]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[558]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[558]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[559]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]

Drug(s) Affected By Calretinin (CALB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[372]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[560]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[561]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[322]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[431]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[562]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[563]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[564]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[218]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[433]
Mirtazapine	DML53ZJ	Depression	6A70-6A7Z	Approved	[565]
Methamphetamine	DMPM4SK	Anxiety		Approved	[566]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[267]

Drug(s) Affected By Liver carboxylesterase 1 (CES1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[567]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[69]
Dextropropoxyphene	DM23HCX	Pain	MG30-MG3Z	Approved	[568]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[569]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[570]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[571]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[572]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[573]

Drug(s) Affected By Proteinase-activated receptor 1 (F2R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[200]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[574]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[575]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[576]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[576]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[265]

Drug(s) Affected By Zinc-alpha-2-glycoprotein (AZGP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[367]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[369]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[577]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[578]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[579]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[410]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[577]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]

Drug(s) Affected By Protein S100-P (S100P)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[580]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[36]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[96]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[581]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[582]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]

Drug(s) Affected By G0/G1 switch protein 2 (G0S2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Selenium	DM25CGV	N. A.	N. A.	Approved	[208]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[413]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[524]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[413]

Drug(s) Affected By Calmodulin-like protein 3 (CALML3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[38]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[83]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[369]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[495]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]

Drug(s) Affected By CCN family member 2 (CCN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[583]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[240]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[413]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[290]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[37]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[584]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]

Drug(s) Affected By Transketolase (TKT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[412]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[493]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[585]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[557]

Drug(s) Affected By 2'-5'-oligoadenylate synthase 2 (OAS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[586]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[489]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[381]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[382]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[587]
Amantadine	DMS3YE9	Influenza A virus infection	1E30	Approved	[588]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[348]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[589]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[590]

Drug(s) Affected By Aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[591]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[38]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[592]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[593]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[594]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[557]

Drug(s) Affected By Protein S100-A7 (S100A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[334]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[334]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[369]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[595]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[334]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[590]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[312]
all-trans-4-oxo-retinoic acid	DMM2R1N	Discovery agent	N.A.	Investigative	[334]

Drug(s) Affected By Glycerol kinase (GK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[172]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[596]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[594]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[413]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[65]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[597]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[303]

Drug(s) Affected By Guanylate-binding protein 2 (GBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[381]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[218]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]

Drug(s) Affected By Cystathionine gamma-lyase (CTH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[262]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[83]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[120]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[116]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[302]

Drug(s) Affected By Ribonuclease 4 (RNASE4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[413]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[290]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[307]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[435]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[305]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[94]

Drug(s) Affected By Trypsin-3 (PRSS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[65]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[351]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[598]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[547]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[352]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[599]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[600]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[601]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[602]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[603]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[604]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[605]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[583]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[383]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[606]

Drug(s) Affected By Cystathionine beta-synthase (CBS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[238]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[607]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[195]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[413]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[361]

Drug(s) Affected By Insulin receptor substrate 1 (IRS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[72]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[608]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[609]

Drug(s) Affected By Transcription factor SOX-11 (SOX11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[504]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[504]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[439]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[261]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[610]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[291]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]

Drug(s) Affected By Glutaredoxin-1 (GLRX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[307]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[550]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[553]

Drug(s) Affected By ADP-ribosylation factor-like protein 3 (ARL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[305]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[292]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[291]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[292]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[611]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]

Drug(s) Affected By GMP reductase 1 (GMPR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[612]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[304]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[613]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[261]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[612]

Drug(s) Affected By 17-beta-hydroxysteroid dehydrogenase type 2 (HSD17B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[614]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[614]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[367]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[615]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[495]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]

Drug(s) Affected By Pre-B-cell leukemia transcription factor 1 (PBX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[262]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[320]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[148]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[258]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[616]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[348]

Drug(s) Affected By DNA-binding protein inhibitor ID-1 (ID1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[617]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[299]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[246]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[618]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[119]

Drug(s) Affected By Signal transducer and activator of transcription 1-alpha/beta (STAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[231]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[619]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[178]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[620]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[272]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[511]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[489]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[381]

Drug(s) Affected By ETS translocation variant 4 (ETV4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[495]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Bortezomib	DMNO38U	Leukemia		Approved	[65]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[621]

Drug(s) Affected By Nuclear receptor subfamily 4 group A member 2 (NR4A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[622]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[623]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[241]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[121]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[446]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[261]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[218]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[624]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[623]

Drug(s) Affected By Radiation-inducible immediate-early gene IEX-1 (IER3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Selenium	DM25CGV	N. A.	N. A.	Approved	[208]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[119]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[83]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]

Drug(s) Affected By Microtubule-associated protein 1B (MAP1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[625]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[626]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[300]

Drug(s) Affected By DNA-binding protein inhibitor ID-4 (ID4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[550]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[627]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[435]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[551]

Drug(s) Affected By DNA-binding protein RFX5 (RFX5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[304]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[305]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[127]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[514]

Drug(s) Affected By Transcription factor SOX-2 (SOX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[299]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[628]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[629]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[584]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[630]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[631]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]

Drug(s) Affected By Lanosterol synthase (LSS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[485]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[412]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[485]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[485]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[485]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[172]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[413]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[486]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[485]

Drug(s) Affected By Heat shock 70 kDa protein 13 (HSPA13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[625]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[490]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[370]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[305]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[94]

Drug(s) Affected By Selenoprotein P (SELENOP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[122]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[596]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1C (CDKN1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[245]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[334]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[334]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[65]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[351]

Drug(s) Affected By Serpin B9 (SERPINB9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[334]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[334]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[632]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]

Drug(s) Affected By Sodium/myo-inositol cotransporter (SLC5A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[357]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[359]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[516]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[108]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[257]

Drug(s) Affected By Growth arrest-specific protein 1 (GAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[241]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[369]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[354]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[553]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[633]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[325]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[634]

Drug(s) Affected By ADP-ribosylhydrolase ARH1 (ADPRH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[265]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[310]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[123]
OAADPR	DM458IH	Discovery agent	N.A.	Investigative	[635]

Drug(s) Affected By GTP-binding protein RAD (RRAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[381]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[218]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[636]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[354]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[637]

Drug(s) Affected By SH3 domain-binding glutamic acid-rich protein (SH3BGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[509]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[261]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[127]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[406]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[261]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]

Drug(s) Affected By Claudin-8 (CLDN8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[638]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[639]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[639]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[356]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[640]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[577]

Drug(s) Affected By Serine/threonine-protein kinase SIK1 (SIK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[93]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[372]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[93]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[93]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[354]

Drug(s) Affected By Caspase recruitment domain-containing protein 18 (CARD18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[55]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[304]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[123]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[312]

Drug(s) Affected By Sestrin-3 (SESN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[201]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[291]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[139]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[490]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[550]

Drug(s) Affected By cAMP-dependent protein kinase inhibitor alpha (PKIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[372]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Bortezomib	DMNO38U	Leukemia		Approved	[65]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[304]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[348]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[142]

Drug(s) Affected By SH3 domain-binding protein 2 (SH3BP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[407]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[348]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[318]

Drug(s) Affected By Cyclin-A1 (CCNA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[193]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[641]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[489]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[444]
Atropine	DMEN6X7	Organophosphate poisoning	NE6Z	Approved	[642]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[643]

Drug(s) Affected By Arginase-2, mitochondrial (ARG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[411]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[263]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[302]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[644]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]

Drug(s) Affected By Neutrophil gelatinase-associated lipocalin (LCN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[334]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[334]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[319]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[369]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[645]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[351]

Drug(s) Affected By DNA-binding protein SATB1 (SATB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[497]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[148]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[507]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[267]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[305]

Drug(s) Affected By Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[83]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[258]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[108]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[354]

Drug(s) Affected By Guanylate cyclase soluble subunit beta-1 (GUCY1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[257]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[362]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[533]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[547]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[547]
Glyceryl trinitrate	DMF72W3	N. A.	N. A.	Phase 4	[646]

Drug(s) Affected By DNA-binding protein inhibitor ID-3 (ID3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[299]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[647]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[256]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[45]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[648]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[37]

Drug(s) Affected By Transforming growth factor beta receptor type 3 (TGFBR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[649]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[241]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[86]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[148]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[108]

Drug(s) Affected By Tumor necrosis factor alpha-induced protein 2 (TNFAIP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[37]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[650]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[55]

Drug(s) Affected By Peroxisome proliferator-activated receptor delta (PPARD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[87]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[651]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[652]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[653]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[654]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[594]
Gemfibrozil	DMD8Q3J	Hyperlipidaemia	5C80	Approved	[655]

Drug(s) Affected By 2-5A-dependent ribonuclease (RNASEL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[265]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[304]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[656]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[265]

Drug(s) Affected By Glutamine--fructose-6-phosphate aminotransferase 1 (GFPT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
L-glutamine	DM69G8X	Short bowel syndrome	KB89.1	Approved	[198]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[198]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[424]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[300]

Drug(s) Affected By Early growth response protein 3 (EGR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[647]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[83]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[581]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[241]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[265]

Drug(s) Affected By Transcription factor SOX-4 (SOX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[657]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[381]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]

Drug(s) Affected By 3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[658]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[218]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[148]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[522]
Roflumilast	DMPGHY8	Asthma	CA23	Approved	[659]

Drug(s) Affected By Bone marrow stromal antigen 2 (BST2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[382]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[37]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]

Drug(s) Affected By BMP and activin membrane-bound inhibitor homolog (BAMBI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[411]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[657]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[218]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]

Drug(s) Affected By Growth factor receptor-bound protein 10 (GRB10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[511]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[307]

Drug(s) Affected By Interferon-induced protein with tetratricopeptide repeats 5 (IFIT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[590]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[127]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[313]

Drug(s) Affected By Gamma-sarcoglycan (SGCG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[590]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[406]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[310]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[353]

Drug(s) Affected By Phospholipase D1 (PLD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[262]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[490]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[660]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[351]

Drug(s) Affected By Nuclear factor of activated T-cells, cytoplasmic 2 (NFATC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[424]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[55]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Hydroxychloroquine	DMSIVND	Chronic renal failure	GB61.Z	Approved	[661]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[373]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[385]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[662]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 3 (BIRC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[663]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[137]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[161]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[145]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[319]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[664]

Drug(s) Affected By Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[665]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[666]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[667]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[511]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[668]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[669]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[97]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[549]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]

Drug(s) Affected By Septin-6 (SEPTIN6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[85]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[348]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[261]

Drug(s) Affected By Frizzled-2 (FZD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[338]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[670]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[108]

Drug(s) Affected By Raftlin (RFTN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[357]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[218]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[316]

Drug(s) Affected By Calcium-activated chloride channel regulator 4 (CLCA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[123]

Drug(s) Affected By Ribosomal protein S6 kinase alpha-2 (RPS6KA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[172]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[195]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[660]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[266]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[504]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]

Drug(s) Affected By Corneodesmosin (CDSN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[211]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[211]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[435]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[312]

Drug(s) Affected By Ras-related protein Rab-30 (RAB30)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[386]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[313]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[671]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[515]

Drug(s) Affected By Cystatin-M (CST6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[145]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[495]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[257]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[587]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[418]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[127]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[406]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[291]

Drug(s) Affected By Cysteine and glycine-rich protein 2 (CSRP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[215]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]

Drug(s) Affected By Lymphocyte antigen 6E (LY6E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[37]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[37]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[37]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[37]

Drug(s) Affected By Dual specificity protein phosphatase 5 (DUSP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[672]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[93]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]

Drug(s) Affected By Glutaminyl-peptide cyclotransferase (QPCT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[449]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[235]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[587]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]

Drug(s) Affected By Carbonic anhydrase 9 (CA9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetazolamide	DM1AF5U	Absence epilepsy		Approved	[673]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[674]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[675]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[369]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[39]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Bortezomib	DMNO38U	Leukemia		Approved	[676]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[435]

Drug(s) Affected By Phosphoenolpyruvate carboxykinase , mitochondrial (PCK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[413]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[493]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[473]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[300]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[677]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[413]

Drug(s) Affected By Dual specificity protein phosphatase 6 (DUSP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[678]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[679]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[218]

Drug(s) Affected By Keratin, type I cytoskeletal 24 (KRT24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[562]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[406]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[312]

Drug(s) Affected By Hereditary hemochromatosis protein (HFE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[489]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[623]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[348]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[556]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[261]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[500]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[680]
cinnamaldehyde	DMZDUXG	Discovery agent	N.A.	Investigative	[681]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[682]

Drug(s) Affected By Mitochondrial 10-formyltetrahydrofolate dehydrogenase (ALDH1L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[302]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[258]
Indomethacin	DMSC4A7	Bursitis		Approved	[683]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[304]
Mitotane	DMU1GX0	Adrenocortical carcinoma	2D11.Z	Approved	[684]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[259]

Drug(s) Affected By Galectin-related protein (LGALSL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[305]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[510]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[551]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[142]

Drug(s) Affected By Ankyrin repeat and death domain-containing protein 1A (ANKDD1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[218]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[504]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[504]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[261]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[357]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[123]

Drug(s) Affected By Serine/threonine-protein kinase SBK1 (SBK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[369]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[528]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[261]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[685]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[310]
UNC0379	DMD1E4J	Hepatocellular carcinoma	2C12.02	Preclinical	[686]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[123]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[218]

Drug(s) Affected By Programmed cell death protein 4 (PDCD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[687]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[688]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[687]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[120]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[689]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[687]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]

Drug(s) Affected By Glycerol-3-phosphate acyltransferase 3 (GPAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[411]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[93]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[93]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[416]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[265]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[93]

Drug(s) Affected By Interferon-induced protein 44-like (IFI44L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[37]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[489]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[381]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[291]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[218]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[37]

Drug(s) Affected By Retroviral-like aspartic protease 1 (ASPRV1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[61]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[310]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[123]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[312]

Drug(s) Affected By Sigma intracellular receptor 2 (TMEM97)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[690]

Drug(s) Affected By UMP-CMP kinase 2, mitochondrial (CMPK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[691]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[148]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[361]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[267]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[304]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[305]

Drug(s) Affected By RRP12-like protein (RRP12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[263]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[424]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[93]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[692]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[93]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]

Drug(s) Affected By Signal-regulatory protein beta-2 (SIRPB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[331]

Drug(s) Affected By Calcium homeostasis modulator protein 6 (CALHM6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[613]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[261]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[261]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[685]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[312]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[352]

Drug(s) Affected By Exosome complex component MTR3 (EXOSC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[232]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[94]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[500]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[312]

Drug(s) Affected By Synaptonemal complex protein 2-like (SYCP2L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[235]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[267]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[693]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[265]

Drug(s) Affected By Proline-rich protein 9 (PRR9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[351]

Drug(s) Affected By Protein furry homolog (FRY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[265]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[218]
Bortezomib	DMNO38U	Leukemia		Approved	[65]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[354]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[305]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[430]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[551]

Drug(s) Affected By NEDD4-binding protein 2-like 1 (N4BP2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[493]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[413]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[65]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[148]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[504]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]

Drug(s) Affected By Transcription initiation factor TFIID subunit 3 (TAF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[361]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[325]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[417]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[361]
Josamycin	DMKJ8LB	Bacterial infection	1A00-1C4Z	Approved	[694]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[313]

Drug(s) Affected By LEM domain-containing protein 1 (LEMD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[351]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[419]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[695]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[127]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[291]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[696]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[61]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[312]

Drug(s) Affected By Scavenger receptor class A member 3 (SCARA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[233]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[241]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[108]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[697]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]

Drug(s) Affected By Multiple C2 and transmembrane domain-containing protein 2 (MCTP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flucloxacillin	DMNUWST	Bacterial infection	1A00-1C4Z	Approved	[698]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[372]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[261]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[406]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[547]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[424]

Drug(s) Affected By Multiple C2 and transmembrane domain-containing protein 1 (MCTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[351]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[318]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[261]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[127]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[313]

Drug(s) Affected By Elongator complex protein 2 (ELP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[305]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[127]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[310]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[123]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[699]

Drug(s) Affected By Centriole, cilia and spindle-associated protein (CCSAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[357]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[235]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[305]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[577]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[313]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]

Drug(s) Affected By Pyrin and HIN domain-containing protein 1 (PYHIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[218]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[700]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[685]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[352]

Drug(s) Affected By Keratin, type II cytoskeletal 80 (KRT80)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[271]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[271]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[351]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[271]

Drug(s) Affected By Teneurin-4 (TENM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[590]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[261]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[310]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[365]

Drug(s) Affected By Proactivator polypeptide-like 1 (PSAPL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[510]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[419]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[313]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[312]

Drug(s) Affected By Protein FAM117B (FAM117B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[267]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[370]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[313]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]

Drug(s) Affected By NIPA-like protein 3 (NIPAL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[241]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[313]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[261]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[310]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[123]

Drug(s) Affected By Glutamate-rich protein 5 (ERICH5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[305]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[310]

Drug(s) Affected By Surfactant-associated protein 2 (SFTA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[613]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[419]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]

Drug(s) Affected By Golgi-associated kinase 1B (GASK1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[258]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]

Drug(s) Affected By Protein GPR15LG (GPR15LG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]

Drug(s) Affected By Ly6/PLAUR domain-containing protein 5 (LYPD5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[312]

Drug(s) Affected By Serine protease inhibitor Kazal-type 6 (SPINK6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[351]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[312]

Drug(s) Affected By Myelin protein zero-like protein 3 (MPZL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[291]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[267]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[348]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[313]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[309]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[62]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[701]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[702]

Drug(s) Affected By Teashirt homolog 1 (TSHZ1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[381]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[218]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[304]

Drug(s) Affected By Tumor protein p63-regulated gene 1 protein (TPRG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[703]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[123]

Drug(s) Affected By Rho GTPase-activating protein 27 (ARHGAP27)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[307]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[269]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[685]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[310]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[352]

Drug(s) Affected By Lysophospholipid acyltransferase 2 (MBOAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[550]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[704]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[577]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[310]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[699]

Drug(s) Affected By Small integral membrane protein 5 (SMIM5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[61]

Drug(s) Affected By Lysophospholipase D GDPD3 (GDPD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[485]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[705]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[485]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[486]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[486]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[485]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Haloperidol	DM96SE0	Delirium		Approved	[486]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]

Drug(s) Affected By Lysosomal cholesterol signaling protein (GPR155)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[304]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[406]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[261]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[425]

Drug(s) Affected By Transmembrane channel-like protein 6 (TMC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[706]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[148]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[307]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]

Drug(s) Affected By MOB kinase activator 3B (MOB3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[551]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[291]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[707]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[265]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[708]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[709]

Drug(s) Affected By E3 ubiquitin-protein ligase MARCHF3 (MARCHF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[258]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[348]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[419]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[562]

Drug(s) Affected By Kelch repeat and BTB domain-containing protein 6 (KBTBD6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[385]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[313]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[701]

Drug(s) Affected By Transmembrane protein 200A (TMEM200A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[369]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[354]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[316]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[562]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[313]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[123]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[218]

Drug(s) Affected By Cilium assembly protein DZIP1 (DZIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[307]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[304]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[547]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[547]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]

Drug(s) Affected By E3 ubiquitin-protein ligase SIAH1 (SIAH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[411]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[710]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[55]
Hexachlorophene	DMLKSE0	Bacterial infection	1A00-1C4Z	Approved	[711]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]

Drug(s) Affected By Serpin A12 (SERPINA12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[313]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[712]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[312]

Drug(s) Affected By DCN1-like protein 3 (DCUN1D3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[108]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[348]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[313]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[312]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[218]

Drug(s) Affected By Cadherin-like protein 26 (CDH26)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[351]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[257]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[304]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[418]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[312]
2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE	DMNQL17	Discovery agent	N.A.	Investigative	[355]

Drug(s) Affected By Protein mono-ADP-ribosyltransferase PARP9 (PARP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[290]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[305]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[94]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[406]

Drug(s) Affected By Probable ATP-dependent RNA helicase DDX60 (DDX60)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[218]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[351]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[305]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[590]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]

Drug(s) Affected By Threonine synthase-like 1 (THNSL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[381]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[351]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[597]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[305]

Drug(s) Affected By EP300-interacting inhibitor of differentiation 3 (EID3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[235]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[307]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[94]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[313]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[310]

Drug(s) Affected By Keratin, type II cytoskeletal 78 (KRT78)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[671]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[331]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[312]

Drug(s) Affected By Serine/threonine-protein kinase 40 (STK40)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[65]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[304]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[305]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[142]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[127]

Drug(s) Affected By Protein FAM43A (FAM43A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[299]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[148]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]

Drug(s) Affected By Angiogenic factor with G patch and FHA domains 1 (AGGF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[381]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[361]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[303]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[304]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[305]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[261]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[361]

Drug(s) Affected By ELMO domain-containing protein 1 (ELMOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[241]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[406]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[291]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[291]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[123]

Drug(s) Affected By Secreted frizzled-related protein 1 (SFRP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[713]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[321]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[397]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[55]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[490]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]

Drug(s) Affected By Actin filament-associated protein 1 (AFAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[424]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[626]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[304]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[348]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]

Drug(s) Affected By Transcription elongation factor A N-terminal and central domain-containing protein (TCEANC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[310]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[714]

Drug(s) Affected By Prostaglandin reductase 2 (PTGR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[357]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[325]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[293]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[313]

Drug(s) Affected By Fibrous sheath-interacting protein 1 (FSIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[261]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[562]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[715]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[716]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[430]

Drug(s) Affected By Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[717]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[113]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[718]
Ceritinib	DMB920Z	Non-small-cell lung cancer	2C25.Y	Approved	[719]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[720]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[721]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[721]

Drug(s) Affected By Short-chain dehydrogenase/reductase family 9C member 7 (SDR9C7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[312]

Drug(s) Affected By V-type proton ATPase subunit C 2 (ATP6V1C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[320]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[304]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[510]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[722]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[261]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[723]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[312]

Drug(s) Affected By Retinoic acid-induced protein 3 (GPRC5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[240]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[338]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[489]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[550]

Drug(s) Affected By BPI fold-containing family C protein (BPIFC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[312]

Drug(s) Affected By Delta and Notch-like epidermal growth factor-related receptor (DNER)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[69]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]

Drug(s) Affected By Syntaxin-binding protein 6 (STXBP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[241]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[724]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[725]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[318]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[406]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[721]

Drug(s) Affected By Protein phosphatase PTC7 homolog (PPTC7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[304]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[305]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[318]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[406]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[312]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[218]

Drug(s) Affected By Fin bud initiation factor homolog (FIBIN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[369]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[291]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[726]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[310]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[123]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[312]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[352]

Drug(s) Affected By Polyamine-modulated factor 1-binding protein 1 (PMFBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[267]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[313]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[712]

Drug(s) Affected By Interferon-induced protein 44 (IFI44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[446]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[382]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[218]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[37]
Bortezomib	DMNO38U	Leukemia		Approved	[65]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[37]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[727]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[549]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[444]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[148]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[725]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[291]

Drug(s) Affected By E3 ubiquitin-protein ligase DTX3L (DTX3L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[550]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[305]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[386]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[261]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[406]

Drug(s) Affected By Chondroitin sulfate N-acetylgalactosaminyltransferase 1 (CSGALNACT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[577]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]

Drug(s) Affected By Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[483]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[728]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[406]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[310]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[729]

Drug(s) Affected By SH3 domain and tetratricopeptide repeat-containing protein 1 (SH3TC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[93]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[93]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[93]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[93]

Drug(s) Affected By E3 ubiquitin-protein ligase SH3RF2 (SH3RF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[730]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[316]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[510]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[613]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[562]

Drug(s) Affected By Dual specificity protein phosphatase 19 (DUSP19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[420]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[352]

Drug(s) Affected By Sec1 family domain-containing protein 2 (SCFD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[110]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[316]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[305]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[127]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[685]

Drug(s) Affected By Cell migration-inducing and hyaluronan-binding protein (CEMIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[108]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[316]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[325]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[385]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]

Drug(s) Affected By Pleckstrin homology-like domain family A member 1 (PHLDA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[381]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]

Drug(s) Affected By Kelch repeat and BTB domain-containing protein 7 (KBTBD7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[307]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[504]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[504]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[348]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[127]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[313]

Drug(s) Affected By Glycosylated lysosomal membrane protein (GLMP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[348]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[510]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[577]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[310]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[365]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[312]

Drug(s) Affected By Interleukin-1 family member 10 (IL1F10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[312]

Drug(s) Affected By Protein N-lysine methyltransferase METTL21A (METTL21A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[232]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Bortezomib	DMNO38U	Leukemia		Approved	[65]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[304]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[313]

Drug(s) Affected By E3 ubiquitin-protein ligase MYLIP (MYLIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[305]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[417]

Drug(s) Affected By Cysteine/serine-rich nuclear protein 3 (CSRNP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[348]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[291]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[310]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[500]

Drug(s) Affected By C-type lectin domain family 2 member B (CLEC2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[381]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[261]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[490]
Atenolol	DMNKG1Z	Angina pectoris	BA40	Approved	[731]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[303]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[616]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[348]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[261]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[685]

Drug(s) Affected By Aquaporin-3 (AQP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[399]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[564]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[39]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[732]

Drug(s) Affected By Kallikrein-6 (KLK6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[495]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[504]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[504]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[733]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[590]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[562]

Drug(s) Affected By Rho guanine nucleotide exchange factor 2 (ARHGEF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[734]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[246]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Mebendazole	DMO14SG	Ascariasis	1F62	Approved	[735]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[361]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[504]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]

Drug(s) Affected By Thymic stromal lymphopoietin (TSLP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[257]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[491]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[305]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[387]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[142]

Drug(s) Affected By Transmembrane protein 106A (TMEM106A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[241]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[94]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[94]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[310]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[424]

Drug(s) Affected By Ras-related protein Rab-7b (RAB7B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[235]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[148]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[351]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[291]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[611]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[365]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[265]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[708]

Drug(s) Affected By Transmembrane protein 125 (TMEM125)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[444]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[351]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[124]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[325]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[510]

Drug(s) Affected By Transmembrane protein 45B (TMEM45B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[93]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[351]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[93]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[124]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[353]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[313]

Drug(s) Affected By SH3 domain-containing kinase-binding protein 1 (SH3KBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[232]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[424]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[549]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[300]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[304]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[348]

Drug(s) Affected By Coiled-coil domain-containing protein 127 (CCDC127)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[313]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[310]

Drug(s) Affected By RalBP1-associated Eps domain-containing protein 1 (REPS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[218]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[597]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[127]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[736]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]

Drug(s) Affected By U8 snoRNA-decapping enzyme (NUDT16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[348]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[310]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[729]

Drug(s) Affected By Rho guanine nucleotide exchange factor 26 (ARHGEF26)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[737]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[737]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[737]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[737]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[590]

Drug(s) Affected By Phosphoinositide-3-kinase-interacting protein 1 (PIK3IP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[120]
Idelalisib	DM602WT	Chronic lymphocytic leukaemia	2A82.0	Approved	[738]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[92]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[120]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[148]

Drug(s) Affected By Fumarylacetoacetate hydrolase domain-containing protein 2A (FAHD2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[301]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[585]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
QUERCITRIN	DM1DH96	Discovery agent	N.A.	Investigative	[739]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[680]

Drug(s) Affected By Uncharacterized protein C16orf74 (C16ORF74)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[257]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[310]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[123]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[352]

Drug(s) Affected By Transmembrane protein 19 (TMEM19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[235]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[325]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[127]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[721]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[721]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[310]

Drug(s) Affected By Androgen-dependent TFPI-regulating protein (ADTRP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[740]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[685]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[352]

Drug(s) Affected By Peptidoglycan recognition protein 4 (PGLYRP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[65]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[406]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[312]

Drug(s) Affected By KICSTOR subunit 2 (KICS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[510]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[313]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[310]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[311]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[701]

Drug(s) Affected By Cilia- and flagella-associated protein 44 (CFAP44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[261]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[406]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[261]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[265]

Drug(s) Affected By Tetratricopeptide repeat protein 14 (TTC14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[306]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[305]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[366]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[424]

Drug(s) Affected By Retinol dehydrogenase 12 (RDH12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[351]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[741]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[123]
all-trans-retinal	DM6CEVB	Discovery agent	N.A.	Investigative	[741]

Drug(s) Affected By E3 ubiquitin-protein ligase NEDD4-like (NEDD4L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[549]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[730]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[316]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[742]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[304]

Drug(s) Affected By DEP domain-containing protein 7 (DEPDC7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[69]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[290]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]

Drug(s) Affected By Alpha-protein kinase 1 (ALPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[235]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[406]
Streptozocin	DMOF7AT	Pancreatic cancer	2C10	Approved	[743]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[744]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[291]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]

Drug(s) Affected By Tribbles homolog 3 (TRIB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[413]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[290]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[119]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[120]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[745]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[119]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[121]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]

Drug(s) Affected By Tribbles homolog 1 (TRIB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[307]

Drug(s) Affected By MAP7 domain-containing protein 2 (MAP7D2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[218]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[291]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[424]

Drug(s) Affected By Proheparin-binding EGF-like growth factor (HBEGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[87]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[746]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[747]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[334]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[334]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[301]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]

Drug(s) Affected By P2X purinoceptor 4 (P2RX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[748]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[489]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[267]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[304]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[325]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[386]

Drug(s) Affected By Pituitary homeobox 2 (PITX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[124]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[435]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[94]
Nicotinamide	DMUPE07	Acne vulgaris	ED80	Approved	[749]

Drug(s) Affected By ATP-sensitive inward rectifier potassium channel 15 (KCNJ15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[208]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[83]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[750]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[495]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[309]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[751]

Drug(s) Affected By BAG family molecular chaperone regulator 1 (BAG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[752]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[55]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[185]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[257]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[316]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[293]

Drug(s) Affected By Plakophilin-2 (PKP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[550]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[305]

Drug(s) Affected By Ferroptosis suppressor protein 1 (AIFM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[110]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[93]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[93]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[108]
Bortezomib	DMNO38U	Leukemia		Approved	[65]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]

Drug(s) Affected By Dehydrogenase/reductase SDR family member 6 (BDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[267]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[124]

Drug(s) Affected By E3 ubiquitin-protein ligase TRIM62 (TRIM62)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[348]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[753]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[313]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[754]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[310]

Drug(s) Affected By Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 (ST6GALNAC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[338]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[304]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[127]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[291]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[310]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[701]

Drug(s) Affected By Serine/threonine-protein kinase RIO2 (RIOK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[305]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[424]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[352]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[699]

Drug(s) Affected By Cell division cycle-associated protein 7 (CDCA7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[290]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[218]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[755]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[307]

Drug(s) Affected By GTP-binding protein 2 (GTPBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[65]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[656]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[267]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[348]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[94]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]

Drug(s) Affected By Leucine-rich repeat-containing G-protein coupled receptor 4 (LGR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[368]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[547]

Drug(s) Affected By Cornifelin (CNFN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[624]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[261]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[756]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[61]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[709]

Drug(s) Affected By Angiotensin-converting enzyme 2 (ACE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Captopril	DM458UM	Chronic heart failure	BD1Z	Approved	[757]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[758]
Dantrolene	DM1D8XY	Hyperthermia	MG26	Approved	[758]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[758]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[758]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[758]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[758]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[758]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[758]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[758]

Drug(s) Affected By Hydroperoxide isomerase ALOXE3 (ALOXE3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[211]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[348]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[510]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[61]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[312]

Drug(s) Affected By RanBP-type and C3HC4-type zinc finger-containing protein 1 (RBCK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[195]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[108]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[348]

Drug(s) Affected By Interferon-induced helicase C domain-containing protein 1 (IFIH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[37]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[320]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[37]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[37]

Drug(s) Affected By Protein Niban 1 (NIBAN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[759]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[302]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[549]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[195]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]

Drug(s) Affected By Normal mucosa of esophagus-specific gene 1 protein (C15ORF48)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[290]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[215]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[106]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[419]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[760]

Drug(s) Affected By Protein sprouty homolog 4 (SPRY4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[411]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[235]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[761]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[307]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[411]

Drug(s) Affected By Keratin, type I cytoskeletal 23 (KRT23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[369]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[444]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[483]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[266]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[124]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[94]

Drug(s) Affected By Leucine-rich repeat-containing protein 27 (LRRC27)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[430]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[313]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[310]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[123]

Drug(s) Affected By B-cell lymphoma/leukemia 11B (BCL11B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[123]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[265]

Drug(s) Affected By Very long chain fatty acid elongase 4 (ELOVL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[433]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[419]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[406]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[313]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[309]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]

Drug(s) Affected By Paternally-expressed gene 3 protein (PEG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[632]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
PD-0325901	DM27D4J	Breast cancer	2C60-2C65	Phase 2	[762]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[424]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[763]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[352]

Drug(s) Affected By Cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[369]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[490]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[258]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[435]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[439]

Drug(s) Affected By Coiled-coil domain-containing protein 8 (CCDC8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[351]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[701]

Drug(s) Affected By B-cell lymphoma/leukemia 11A (BCL11A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[265]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[433]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[304]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[291]

Drug(s) Affected By Ribonuclease 7 (RNASE7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[312]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[701]

Drug(s) Affected By Kelch-like protein 31 (KLHL31)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[382]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[313]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[310]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[123]

Drug(s) Affected By CXADR-like membrane protein (CLMP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[549]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[510]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[740]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[309]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[123]

Drug(s) Affected By Thiol S-methyltransferase TMT1A (TMT1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[357]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[321]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[764]

Drug(s) Affected By DNA-directed RNA polymerase I subunit RPA2 (POLR1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[305]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[318]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[293]

Drug(s) Affected By Sp110 nuclear body protein (SP110)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[489]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[381]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[587]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[304]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[305]

Drug(s) Affected By Centrosomal protein 15 (CEP15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[318]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[261]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[547]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[765]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[331]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[310]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[311]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[353]

Drug(s) Affected By Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (PDE11A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[348]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[61]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[766]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[123]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[265]

Drug(s) Affected By Palmdelphin (PALMD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[483]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[305]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[510]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[240]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[215]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]

Drug(s) Affected By Lactosylceramide 4-alpha-galactosyltransferase (A4GALT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[504]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[504]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[406]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[313]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[767]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[310]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[352]

Drug(s) Affected By Arf-GAP with dual PH domain-containing protein 2 (ADAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[351]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[768]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[729]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[312]

Drug(s) Affected By Exosome complex component RRP40 (EXOSC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[261]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[261]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[313]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[366]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[310]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[311]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[353]

Drug(s) Affected By PI-PLC X domain-containing protein 1 (PLCXD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[264]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[218]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[413]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[108]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[62]

Drug(s) Affected By Muscleblind-like protein 3 (MBNL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[321]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[504]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[267]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[348]

Drug(s) Affected By S-acyl fatty acid synthase thioesterase, medium chain (OLAH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[290]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[83]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[594]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[304]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[109]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]

Drug(s) Affected By Syntabulin (SYBU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[304]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[590]

Drug(s) Affected By Very long chain fatty acid elongase 5 (ELOVL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[231]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[215]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[110]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[108]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[305]

Drug(s) Affected By Interleukin-36 gamma (IL36G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[218]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[351]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[419]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[769]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[312]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[218]

Drug(s) Affected By Grainyhead-like protein 1 homolog (GRHL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[594]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[351]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[305]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[406]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[313]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]

Drug(s) Affected By Protein Daple (CCDC88C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[218]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[304]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[318]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[424]

Drug(s) Affected By Ammonium transporter Rh type C (RHCG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ammonia	DMOEVK6	Coronary artery disease	BA80	Approved	[770]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[312]
BRN-3548355	DM4KXT0	N. A.	N. A.	Investigative	[771]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[708]
3-iodothyronamine	DM3L0F8	Discovery agent	N.A.	Investigative	[772]

Drug(s) Affected By Interleukin-36 receptor antagonist protein (IL36RN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[351]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[356]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[352]

Drug(s) Affected By Regulator of G-protein signaling 17 (RGS17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[773]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[304]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[773]
Methamphetamine	DMPM4SK	Anxiety		Approved	[774]

Drug(s) Affected By Cysteine-rich C-terminal protein 1 (CRCT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[172]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[444]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[351]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[491]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[740]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[312]

Drug(s) Affected By E3 ISG15--protein ligase HERC5 (HERC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[37]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[37]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[37]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[37]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[504]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[267]

Drug(s) Affected By TRAF2 and NCK-interacting protein kinase (TNIK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[549]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[550]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[775]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[590]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[291]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[406]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[291]

Drug(s) Affected By Histone deacetylase 9 (HDAC9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[776]
Pirfenidone	DM6VZFQ	Idiopathic pulmonary fibrosis	CB03.4	Approved	[776]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[594]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[218]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Indomethacin	DMSC4A7	Bursitis		Approved	[777]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[553]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[348]

Drug(s) Affected By ETS-related transcription factor Elf-5 (ELF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[444]
Promegestone	DMK4S8I	Gynecological disease	GA6Z	Approved	[778]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[612]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[385]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
SB-431542	DM0YOXQ	Pulmonary fibrosis	CB03.4	Preclinical	[779]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[265]
ORG2058	DMH1M6N	Discovery agent	N.A.	Investigative	[778]

Drug(s) Affected By Phospholipase A and acyltransferase 4 (PLAAT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[92]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[218]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[199]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[351]

Drug(s) Affected By Microtubule-associated tumor suppressor 1 (MTUS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[381]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[261]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[305]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[94]

Drug(s) Affected By NACHT and WD repeat domain-containing protein 2 (NWD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[291]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[424]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[265]

Drug(s) Affected By Polyadenylate-binding protein-interacting protein 2B (PAIP2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[780]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[148]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[406]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[781]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[310]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[312]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[425]

Drug(s) Affected By Transcription factor MafF (MAFF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[87]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[583]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[782]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[172]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[83]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[113]

Drug(s) Affected By Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide (DAPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[232]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[267]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[510]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[352]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[709]

Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[87]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[383]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[357]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[383]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[383]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[783]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[119]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[383]

Drug(s) Affected By Band 4.1-like protein 3 (EPB41L3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[490]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[784]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[267]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[370]

Drug(s) Affected By Guanine deaminase (GDA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[785]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[305]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[313]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[318]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[786]

Drug(s) Affected By Plasmolipin (PLLP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[510]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[562]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[406]

Drug(s) Affected By Sorting nexin-24 (SNX24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[510]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[291]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[94]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[353]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[312]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[265]
cinnamaldehyde	DMZDUXG	Discovery agent	N.A.	Investigative	[681]

Drug(s) Affected By Carbohydrate sulfotransferase 2 (CHST2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[195]
Bortezomib	DMNO38U	Leukemia		Approved	[65]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[325]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[127]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[577]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[261]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]

Drug(s) Affected By Krueppel-like factor 2 (KLF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[241]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[528]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[504]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[305]

Drug(s) Affected By Endothelial lipase (LIPG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[195]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[413]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[148]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]

Drug(s) Affected By Lymphocyte antigen 96 (LY96)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[262]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[413]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[241]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]

Drug(s) Affected By E3 ubiquitin-protein ligase NEURL1B (NEURL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[531]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[406]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[261]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[310]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[787]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[353]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[218]

Drug(s) Affected By Galectin-9 (LGALS9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[304]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[217]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[495]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]

Drug(s) Affected By Late cornified envelope protein 2B (LCE2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[595]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[595]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[304]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[312]
Manganese	DMKT129	N. A.	N. A.	Investigative	[788]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[244]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[279]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[789]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[161]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[281]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[110]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[790]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[791]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[792]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[403]

Drug(s) Affected By Core histone macro-H2A.1 (MACROH2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[267]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[793]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[325]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[261]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[291]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[291]

Drug(s) Affected By Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[794]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[71]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[795]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[276]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[796]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[276]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[111]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[112]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[276]

Drug(s) Affected By Transient receptor potential cation channel subfamily A member 1 (TRPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[797]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[258]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[798]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[799]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[261]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[800]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[309]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]

Drug(s) Affected By Leukocyte cell-derived chemotaxin 1 (CNMD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[801]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[372]
Indomethacin	DMSC4A7	Bursitis		Approved	[777]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[127]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[406]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[291]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[291]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[265]

Drug(s) Affected By Ubiquitin-like protein ATG12 (ATG12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[802]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[145]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[803]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[804]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[805]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[806]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[305]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[560]

Drug(s) Affected By Dickkopf-related protein 1 (DKK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[36]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[264]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[367]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[447]

Drug(s) Affected By 6-phosphogluconolactonase (PGLS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[807]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[267]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[616]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[685]

Drug(s) Affected By Ubiquitin-like modifier-activating enzyme ATG7 (ATG7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[808]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[802]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[717]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[113]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[803]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[809]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[810]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]

Drug(s) Affected By Cytochrome c oxidase subunit 1 (COX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[811]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[328]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[382]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[528]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[812]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[813]
Nicotinamide	DMUPE07	Acne vulgaris	ED80	Approved	[814]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[815]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[71]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[72]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[816]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[193]
Selenium	DM25CGV	N. A.	N. A.	Approved	[817]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[666]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[818]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[819]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]

Drug(s) Affected By GTPase NRas (NRAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[820]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[86]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[821]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[361]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[822]

Drug(s) Affected By GTPase HRas (HRAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[823]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[824]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[820]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[524]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[821]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[825]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]

Drug(s) Affected By GTPase KRas (KRAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[826]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[272]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[83]
Tiazofurin	DM5JWV9	Solid tumour/cancer	2A00-2F9Z	Approved	[827]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[358]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[821]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[381]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[825]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[235]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[828]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[829]
Fructose	DM43AN2	Vomiting	MD90	Approved	[198]
Ketoprofen	DMRKXPT	Bursitis		Approved	[198]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[691]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[830]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[831]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[832]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[833]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[449]

Drug(s) Affected By Immunoglobulin J chain (JCHAIN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[834]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[218]
Coprexa	DMA0WEK	Neurological disorder	6B60	Phase 3	[364]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[685]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[218]
Octanal	DMTN0OK	N. A.	N. A.	Investigative	[421]

Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[198]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[835]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[649]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[199]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[376]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[338]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[836]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[837]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[838]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[839]

Drug(s) Affected By Collagen alpha-1(IV) chain (COL4A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[199]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[258]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[840]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[93]

Drug(s) Affected By Prelamin-A/C (LMNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[145]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[166]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[841]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[572]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[218]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[55]

Drug(s) Affected By Glycophorin-A (GYPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[842]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[843]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[844]
Teriflunomide	DMQ2FKJ	Hyperlipidaemia	5C80	Approved	[845]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[846]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[198]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[847]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[848]
APIGENIN	DMI3491	Discovery agent	N.A.	Investigative	[849]
Butanoic Acid	DMTAJP7	Discovery agent	N.A.	Investigative	[850]

Drug(s) Affected By Protein AMBP (AMBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[851]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[368]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Benazepril	DMH1M9B	Hypertension	BA00-BA04	Approved	[852]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[348]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[291]

Drug(s) Affected By Transferrin receptor protein 1 (TFRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[200]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[853]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[854]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[152]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[211]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[246]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[83]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[120]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[855]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[122]

Drug(s) Affected By RAF proto-oncogene serine/threonine-protein kinase (RAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[856]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[857]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[858]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[859]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[192]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[860]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[861]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[86]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[857]

Drug(s) Affected By Granulocyte-macrophage colony-stimulating factor (CSF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[862]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[863]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[125]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[864]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[865]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[866]
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[867]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[868]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]

Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trastuzumab	DMZQOUX	Breast cancer	2C60-2C65	Approved	[198]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[856]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[869]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[72]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[870]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[245]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[871]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[872]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[873]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[131]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[874]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[875]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[876]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[877]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[878]

Drug(s) Affected By Integrin beta-2 (ITGB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[145]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[879]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[880]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Josamycin	DMKJ8LB	Bacterial infection	1A00-1C4Z	Approved	[881]

Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[71]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[231]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[882]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[883]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[153]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[246]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[111]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[884]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[885]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[37]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[886]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[299]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[213]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[450]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[449]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[451]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[102]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[887]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[438]
Fructose	DM43AN2	Vomiting	MD90	Approved	[198]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[888]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[889]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[71]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[200]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[357]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[890]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[891]

Drug(s) Affected By Integrin beta-1 (ITGB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[199]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[200]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[892]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[38]
Fructose	DM43AN2	Vomiting	MD90	Approved	[893]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[894]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[895]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[896]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[897]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[898]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[280]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[818]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[899]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[900]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[901]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[245]

Drug(s) Affected By Protein S100-A9 (S100A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[448]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[38]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[334]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[334]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[92]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[902]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]

Drug(s) Affected By Involucrin (IVL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[903]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[199]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[904]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[154]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[903]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[905]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[218]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[906]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[199]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[595]

Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[463]
Selenium	DM25CGV	N. A.	N. A.	Approved	[144]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[907]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[908]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[909]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[910]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[911]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[912]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[913]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[578]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[299]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[914]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[450]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[207]
Selenium	DM25CGV	N. A.	N. A.	Approved	[915]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[916]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[917]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[145]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[918]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[919]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[161]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[920]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[283]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[920]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[921]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[922]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[923]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[924]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[925]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[926]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[299]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[889]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[450]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[383]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[201]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[927]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[383]

Drug(s) Affected By Transcriptional activator Myb (MYB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[647]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[245]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[928]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[647]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[503]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[173]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[929]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[930]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[931]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[932]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[198]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[933]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[158]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[830]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[934]

Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[935]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[276]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[936]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[171]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[277]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[937]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[938]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[939]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[940]

Drug(s) Affected By DNA topoisomerase 2-alpha (TOP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[941]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[942]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[200]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[943]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[263]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[944]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[945]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[213]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[583]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[946]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[449]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[947]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[256]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[916]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[948]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[949]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[950]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[583]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[832]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[449]
Selenium	DM25CGV	N. A.	N. A.	Approved	[144]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[951]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[921]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[399]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[952]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[953]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-2 (ATF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[71]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[357]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[954]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[550]
Bortezomib	DMNO38U	Leukemia		Approved	[65]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[93]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[955]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[87]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[201]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[956]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[89]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[957]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[209]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[958]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[211]

Drug(s) Affected By Erythroid transcription factor (GATA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[959]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[842]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Aclarubicin	DMLFZHD	Acute myeloid leukaemia	2A60	Approved	[960]
Pomalidomide	DMTGBAX	Plasma cell myeloma	2A83.1	Approved	[961]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[962]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[963]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[964]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[965]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[966]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[967]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[968]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[969]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[326]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[783]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[970]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[944]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[971]

Drug(s) Affected By Cyclic AMP-responsive element-binding protein 1 (CREB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[972]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[973]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[357]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[892]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[974]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[974]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[975]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[594]

Drug(s) Affected By Transcription factor PU.1 (SPI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[214]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[976]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[977]
Pomalidomide	DMTGBAX	Plasma cell myeloma	2A83.1	Approved	[961]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[978]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[685]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]

Drug(s) Affected By Interleukin-1 receptor antagonist protein (IL1RN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[211]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[290]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[37]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[215]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[979]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[276]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[264]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[276]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[111]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[885]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[113]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[276]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[980]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[981]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[198]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[982]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[983]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[402]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[984]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[120]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[192]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[576]

Drug(s) Affected By Galactoside alpha-(1,2)-fucosyltransferase 1 (FUT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[632]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[489]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[124]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[695]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[410]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[578]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[336]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[71]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[270]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[985]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[204]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[178]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[986]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[402]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[270]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[576]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[576]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[235]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[226]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[55]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]

Drug(s) Affected By Filaggrin (FLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[903]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[334]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[334]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[903]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[444]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[906]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[595]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[334]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[987]

Drug(s) Affected By Kit ligand (KITLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[243]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[402]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[549]
Oxymetholone	DMFXUT8	Aplastic anemia	3A70	Approved	[988]

Drug(s) Affected By Interleukin-10 (IL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[862]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[220]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[989]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[990]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[991]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[992]
Bisoprolol	DM3UZ95	Hypertension	BA00-BA04	Approved	[993]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[994]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[995]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[415]

Drug(s) Affected By Loricrin (LORICRIN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[996]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[906]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[595]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[406]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
SB 203580	DMAET6F	N. A.	N. A.	Terminated	[997]
PD98059	DMZC90M	Cardiac arrest	MC82	Investigative	[997]

Drug(s) Affected By Endothelial transcription factor GATA-2 (GATA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[232]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[842]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[314]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[267]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[998]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[999]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[934]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[455]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1000]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[280]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[502]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[666]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1001]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[199]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[36]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[161]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[1002]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[1003]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[233]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1004]
Fructose	DM43AN2	Vomiting	MD90	Approved	[893]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[199]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[119]

Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[198]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[137]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[450]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[207]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[1005]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1006]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[395]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[166]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]

Drug(s) Affected By DNA cytosine-5)-methyltransferase 1 (DNMT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[244]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1007]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[1008]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[233]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1009]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[1010]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[1011]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1012]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1013]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[1014]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[973]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[830]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[1015]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[1016]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[1017]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1018]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[1019]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1020]

Drug(s) Affected By Aryl hydrocarbon receptor nuclear translocator (ARNT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1021]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1022]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[1023]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[361]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[1024]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[510]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[361]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1025]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[1014]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[1026]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[1027]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[1028]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1013]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[198]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[830]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[1015]

Drug(s) Affected By Caspase-1 (CASP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[118]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1029]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[451]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[1030]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[493]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[96]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[329]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[1031]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[1032]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[876]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[934]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1033]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1034]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[1035]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[1036]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[666]

Drug(s) Affected By 14-3-3 protein sigma (SFN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[243]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[270]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[338]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[271]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1037]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[172]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[271]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[745]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[93]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[888]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1038]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[233]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[910]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1039]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1040]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[1041]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[1042]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[1043]

Drug(s) Affected By Small proline-rich protein 2B (SPRR2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[595]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[439]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[431]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[311]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[312]

Drug(s) Affected By Transaldolase (TALDO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[93]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]

Drug(s) Affected By Breast cancer type 1 susceptibility protein (BRCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[455]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1044]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1045]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[272]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[940]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]

Drug(s) Affected By Thrombopoietin receptor (MPL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[844]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[313]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[312]

Drug(s) Affected By Interleukin-15 (IL15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[243]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[265]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[218]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[1046]
Bortezomib	DMNO38U	Leukemia		Approved	[65]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[1047]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]

Drug(s) Affected By T-lymphocyte activation antigen CD86 (CD86)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1048]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[220]
Kanamycin	DM2DMPO	Bacteremia	1A73	Approved	[1049]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[854]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[1049]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[854]

Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[1050]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[982]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[1051]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[808]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1052]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[666]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[1053]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1054]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[524]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[1053]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 2A (CDKN2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[243]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[232]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[282]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[667]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[402]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[648]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[872]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1055]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[1056]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1057]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[888]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[832]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[207]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[890]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[402]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[884]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[1058]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[890]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[1059]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1060]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1061]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[1003]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1062]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[125]
Fructose	DM43AN2	Vomiting	MD90	Approved	[893]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1063]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[1064]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[404]

Drug(s) Affected By Stromal cell-derived factor 1 (CXCL12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[199]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[647]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1065]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[83]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[647]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[1066]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[1066]

Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[87]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[207]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[102]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[412]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[394]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1067]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[1068]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[116]

Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[87]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[357]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[412]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1069]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[83]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[120]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[745]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[657]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[1070]

Drug(s) Affected By Caspase-4 (CASP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[71]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[200]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[264]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[168]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[180]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]

Drug(s) Affected By Interleukin-1 receptor-associated kinase 1 (IRAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[402]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1071]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[397]
Bortezomib	DMNO38U	Leukemia		Approved	[1072]

Drug(s) Affected By Rho GDP-dissociation inhibitor 1 (ARHGDIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[171]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[581]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[1073]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[39]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[155]

Drug(s) Affected By Caspase-7 (CASP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[950]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[71]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1074]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[1075]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[1076]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[1076]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[145]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[178]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1077]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[944]

Drug(s) Affected By BH3-interacting domain death agonist (BID)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[161]
Selenium	DM25CGV	N. A.	N. A.	Approved	[50]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[402]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1078]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1079]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]

Drug(s) Affected By Gasdermin-D (GSDMD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[691]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[1080]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[1081]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[1080]
Ropivacaine	DMSPJG2	Anaesthesia	9A78.6	Approved	[1082]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[1083]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]

Drug(s) Affected By Inhibin beta E chain (INHBE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[485]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[705]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[485]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[485]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[485]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[413]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[486]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[485]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]

Drug(s) Affected By Growth factor receptor-bound protein 2 (GRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[232]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1084]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[86]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[1085]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[207]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1086]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[97]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[660]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[1087]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[1088]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[1089]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[325]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[1090]

Drug(s) Affected By Hemoglobin subunit beta (HBB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[262]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[1091]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Voxelotor	DMCS6M5	Sickle-cell disorder	3A51	Approved	[1092]
Ibrutinib	DMHZCPO	Mantle cell lymphoma	2A85.5	Approved	[1093]
Flucloxacillin	DMNUWST	Bacterial infection	1A00-1C4Z	Approved	[1094]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[1095]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[1096]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[439]

Drug(s) Affected By Protein jagged-1 (JAG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[338]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[493]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[291]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[531]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[258]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]

Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[55]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[531]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[1097]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[266]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[554]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[1098]

Drug(s) Affected By Protein S100-A12 (S100A12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[399]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Miglitol	DMXBQAM	Diabetic complication	5A2Y	Approved	[1099]
Arecoline	DMFJZK3	Parkinson disease	8A00.0	Phase 1	[1100]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[312]
D-glucose	DMMG2TO	Discovery agent	N.A.	Investigative	[1101]

Drug(s) Affected By Cytochrome c (CYCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[1102]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[918]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[159]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[936]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[1075]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1103]
Pefloxacin	DM49IGF	Gonococcal urethritis	1A70.0Y	Approved	[1104]

Drug(s) Affected By Nuclear factor NF-kappa-B p100 subunit (NFKB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[71]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[524]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[594]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]

Drug(s) Affected By E3 ubiquitin-protein ligase Mdm2 (MDM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Flucytosine	DM13VTW	Cryptococcal meningitis		Approved	[1105]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[1105]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1106]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[145]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1107]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[872]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[120]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[1108]

Drug(s) Affected By Transcription factor E2F1 (E2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1109]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[1110]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1111]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[45]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[899]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[38]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]

Drug(s) Affected By Melanocyte-stimulating hormone receptor (MC1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[1112]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[124]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[313]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[1113]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[1113]
GUAIACOL	DMN4E7T	N. A.	N. A.	Phase 3	[1113]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[1113]
Puerarin	DMJIMXH	Alcohol dependence	6C40.2	Phase 2	[1113]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[934]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1045]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[986]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[166]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[1115]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 9 (TNFRSF9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[199]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1116]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[223]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[218]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[55]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[185]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[929]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[137]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[933]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[199]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[159]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[280]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[1117]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[283]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[876]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1118]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[161]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1119]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[145]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[1105]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[401]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[402]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[125]

Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[830]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[199]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[1120]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[399]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[1121]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[233]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[153]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[199]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[1122]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[405]

Drug(s) Affected By CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase (ST3GAL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1123]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[304]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[325]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[310]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[422]

Drug(s) Affected By TAR DNA-binding protein 43 (TARDBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]
Doxycycline	DM7ICNU	Acne vulgaris	ED80	Approved	[1124]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[1125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[572]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Hexachlorophene	DMLKSE0	Bacterial infection	1A00-1C4Z	Approved	[1126]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[504]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[982]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[1051]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1127]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[262]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[1128]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[110]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[493]

Drug(s) Affected By Histone deacetylase 1 (HDAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[511]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[594]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[1130]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[305]

Drug(s) Affected By Runt-related transcription factor 2 (RUNX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[835]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1131]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1132]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1133]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[1134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[43]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[93]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[93]

Drug(s) Affected By Interleukin-18 (IL18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1135]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[1136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[825]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[1137]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[825]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]

Drug(s) Affected By Kelch-like ECH-associated protein 1 (KEAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1138]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[411]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[493]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[93]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[174]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[1139]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[93]

Drug(s) Affected By Beclin-1 (BECN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[1140]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1052]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[717]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[1141]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1142]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1143]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[1144]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[1145]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[1146]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1147]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[1148]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1060]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1149]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[161]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[163]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]

Drug(s) Affected By LIM and SH3 domain protein 1 (LASP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[521]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[305]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[430]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[1150]

Drug(s) Affected By 2'-5'-oligoadenylate synthase-like protein (OASL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[413]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[37]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[495]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[489]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[413]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[108]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[37]

Drug(s) Affected By ELAV-like protein 1 (ELAVL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[1151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[549]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[1151]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[1152]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[325]
Amsacrine	DMZKYIV	Acute lymphoblastic leukaemia	2A85	Approved	[1153]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[1154]

Drug(s) Affected By Histone-lysine N-methyltransferase EZH2 (EZH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[326]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[424]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1155]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1156]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[596]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[625]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[914]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[71]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[201]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[342]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[957]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[209]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[1157]

Drug(s) Affected By Laminin subunit alpha-4 (LAMA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[40]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[381]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[372]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[413]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[413]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]

Drug(s) Affected By Mitogen-activated protein kinase 14 (MAPK14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1158]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[625]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[207]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[990]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1159]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[284]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[1059]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1160]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1161]

Drug(s) Affected By Filaggrin-2 (FLG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[595]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[595]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[680]

Drug(s) Affected By Transcription factor E4F1 (E4F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[1162]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[366]
ELLAGIC ACID	DMX8BS5	Discovery agent	N.A.	Investigative	[1162]

Drug(s) Affected By Thiol S-methyltransferase TMT1B (TMT1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[235]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[510]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[406]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[261]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[261]

Drug(s) Affected By Repetin (RPTN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[595]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[351]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[312]

Drug(s) Affected By Maestro heat-like repeat family member 5 (MROH5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[123]

Drug(s) Affected By Protein S100-A7A (S100A7A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[595]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[304]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[1163]

Drug(s) Affected By Beta/gamma crystallin domain-containing protein 2 (CRYBG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[356]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[613]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[142]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[313]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[261]

Drug(s) Affected By Leucine-rich repeat-containing protein 71 (LRRC71)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[325]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[539]

Drug(s) Affected By SID1 transmembrane family member 2 (SIDT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[218]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[504]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[124]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[370]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]

Drug(s) Affected By DEP domain-containing mTOR-interacting protein (DEPTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[107]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[258]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[108]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[756]

Drug(s) Affected By Histone deacetylase 2 (HDAC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1164]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[1068]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[976]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[1165]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[490]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[1166]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[124]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1167]

Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-1 (SIRT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1020]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1168]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[1169]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[319]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[1170]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Olaparib	DM8QB1D	Ovarian cancer	2C73	Approved	[1171]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]

Drug(s) Affected By Histone-lysine N-methyltransferase EHMT2 (EHMT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[1172]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[287]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[110]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Bortezomib	DMNO38U	Leukemia		Approved	[65]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]

Drug(s) Affected By NACHT, LRR and PYD domains-containing protein 3 (NLRP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Selenium	DM25CGV	N. A.	N. A.	Approved	[208]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1135]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[147]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[1173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[1174]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1175]
Atropine	DMEN6X7	Organophosphate poisoning	NE6Z	Approved	[448]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[448]

Drug(s) Affected By Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[119]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1176]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[302]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[1176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Racecadotril	DMFOTZ7	Diarrhea	ME05.1	Approved	[1177]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[65]

Drug(s) Affected By Late cornified envelope protein 3D (LCE3D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[595]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[595]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]

Drug(s) Affected By Small proline-rich protein 2G (SPRR2G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[595]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[595]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]

Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[1051]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1052]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1178]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[113]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[1179]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[803]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[804]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[1180]

Drug(s) Affected By Autophagy protein 5 (ATG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[808]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1178]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[803]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[804]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[809]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[1145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[929]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[261]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]

Drug(s) Affected By NADPH oxidase 4 (NOX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1181]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[242]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[1182]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[413]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[106]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[155]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[1183]
ANGIOTENSIN II	DMLWQ27	Increase blood pressure	BA04	Approved	[1184]

Drug(s) Affected By Nuclear receptor-binding protein 2 (NRBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[150]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]

Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1020]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[884]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[884]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[1185]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[1186]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1187]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[313]

Drug(s) Affected By Protein AATF (AATF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[1188]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[1189]
PF-3758309	DM36PKZ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[1190]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[366]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[424]

Drug(s) Affected By Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[794]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[71]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[276]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[276]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1191]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[276]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[111]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[112]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[114]

Drug(s) Affected By Methyl-CpG-binding domain protein 2 (MBD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[41]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1192]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[372]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[1193]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[1194]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[304]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1195]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[419]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[1196]

Drug(s) Affected By DNA (DNMT3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1009]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1197]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1198]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[444]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[307]

Drug(s) Affected By Small proline-rich protein 3 (SPRR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[595]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[533]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[595]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[304]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[417]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[61]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[312]

Drug(s) Affected By Tight junction protein ZO-2 (TJP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[241]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[369]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[57]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[108]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[504]

Drug(s) Affected By DnaJ homolog subfamily B member 4 (DNAJB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[125]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[119]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[120]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[193]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[121]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]

Drug(s) Affected By Lymphoid enhancer-binding factor 1 (LEF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[84]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[86]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[1199]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[1200]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[1201]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[1202]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[261]
Thymoquinone	DMVDTR2	Polycystic ovarian syndrome	5A80.1	Phase 2/3	[1203]

Drug(s) Affected By Apoptosis-associated speck-like protein containing a CARD (PYCARD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[291]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[329]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1204]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[55]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[1205]

Drug(s) Affected By Sialidase-3 (NEU3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1206]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[325]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[510]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[313]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[1207]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[310]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[424]

Drug(s) Affected By Proliferation-associated protein 2G4 (PA2G4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[232]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[246]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[100]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[444]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[39]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[550]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[616]

Drug(s) Affected By TNF receptor-associated factor 6 (TRAF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[264]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[191]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[110]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[104]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[196]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[55]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[1208]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[492]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]

Drug(s) Affected By DNA (DNMT3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1007]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1009]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1197]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[1209]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[235]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1198]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[1193]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[66]

Drug(s) Affected By Catalase (CAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[201]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1210]
Haloperidol	DM96SE0	Delirium		Approved	[198]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[1211]
Selenium	DM25CGV	N. A.	N. A.	Approved	[1212]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[1213]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[1214]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1215]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]

Drug(s) Affected By Glutathione S-transferase P (GSTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[1216]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[1217]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[1217]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[1218]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[87]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[73]
Selenium	DM25CGV	N. A.	N. A.	Approved	[109]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[171]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[1219]

Drug(s) Affected By DNA polymerase eta (POLH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[357]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[39]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[90]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[358]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[235]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[218]
Lomustine	DMMWSUL	Brain cancer	2A00	Approved	[1220]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[1220]

Drug(s) Affected By Myeloperoxidase (MPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[198]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[267]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[198]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[198]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1221]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[1222]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[986]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[1223]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1224]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[1225]

Drug(s) Affected By Glutathione S-transferase theta-1 (GSTT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1226]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[99]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[361]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[304]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[348]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[268]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[318]

Drug(s) Affected By Glutathione S-transferase Mu 1 (GSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[1216]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[1227]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[547]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1228]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[334]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[334]
Methyldopa	DM5I621	Hypertension	BA00-BA04	Approved	[1229]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[42]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[63]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Glycoprotein IIb/IIIa receptor (GPIIb/IIIa)	TT38RM1	ITA2B_HUMAN; ITB3_HUMAN	Antagonist	[2]
Tyrosinase (TYR)	TTULVH8	TYRO_HUMAN	Inhibitor	[3]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[4]
Fumarate reductase flavoprotein (frdA)	DEQUXZ5	FRDA_WOLSU	Substrate	[5]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
14-3-3 protein sigma (SFN)	OTLJCZ1U	1433S_HUMAN	Gene/Protein Processing	[6]
17-beta-hydroxysteroid dehydrogenase type 2 (HSD17B2)	OT3K7HY5	DHB2_HUMAN	Gene/Protein Processing	[7]
2'-5'-oligoadenylate synthase 1 (OAS1)	OT8ZLOCY	OAS1_HUMAN	Gene/Protein Processing	[7]
2'-5'-oligoadenylate synthase 2 (OAS2)	OT64CCTM	OAS2_HUMAN	Gene/Protein Processing	[7]
2'-5'-oligoadenylate synthase-like protein (OASL)	OTZ05YRP	OASL_HUMAN	Gene/Protein Processing	[8]
2-5A-dependent ribonuclease (RNASEL)	OTP6UQUP	RN5A_HUMAN	Gene/Protein Processing	[7]
3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B)	OTOA8WU2	PDE4B_HUMAN	Gene/Protein Processing	[7]
3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3 (FUT3)	OTXQ6P8R	FUT3_HUMAN	Gene/Protein Processing	[7]
6-phosphogluconolactonase (PGLS)	OTO6C0IQ	6PGL_HUMAN	Gene/Protein Processing	[9]
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[10]

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [2] Accutin, a new disintegrin, inhibits angiogenesis in vitro and in vivo by acting as integrin alphavbeta3 antagonist and inducing apoptosis. Blood. 1998 Nov 1;92(9):3268-76.
• [3] Identification of an Alkylhydroquinone from Rhus succedanea as an Inhibitor of Tyrosinase and Melanogenesis. J Agric Food Chem. 2009 Mar 25;57(6):2200-5.
• [4] Metabolism of (S)-5,6-difluoro-4-cyclopropylethynyl-4-trifluoromethyl-3, 4-dihydro-2(1H)-quinazolinone, a non-nucleoside reverse transcriptase inhibitor, in human liver microsomes. Metabolic activation and enzyme kinetics. Drug Metab Dispos. 2003 Jan;31(1):122-32.
• [5] Wolinella succinogenes quinol:fumarate reductase and its comparison to E. coli succinate:quinone reductase. FEBS Lett. 2003 Nov 27;555(1):21-8.
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