Details of the Drug Combination

General Information of Drug Combination (ID: DCIUFM5)

• Drug Combination Name: Gemcitabine + Irinotecan
• Indication: Pancreatic Cancer; Status: Phase 2 [1]
• Component Drugs:
  Gemcitabine (DMSE3I7): Small molecular drug
  Irinotecan (DMP6SC2): Small molecular drug

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Gemcitabine

Disease Entry	ICD 11	Status	REF
Anterior urethra cancer	N.A.	Approved	[2]
Biliary tract cancer	2C17	Approved	[2]
Carcinoma	2A00-2F9Z	Approved	[2]
Cervical cancer	2C77.0	Approved	[2]
Cholangiocarcinoma	2C12.10	Approved	[2]
Fallopian tube neoplasm	N.A.	Approved	[2]
Gallbladder carcinoma	N.A.	Approved	[2]
Leiomyosarcoma	2B58	Approved	[2]
Leukemia	N.A.	Approved	[2]
Lung cancer	2C25.0	Approved	[2]
MALT lymphoma	N.A.	Approved	[2]
Nodal marginal zone lymphoma	2A85.0	Approved	[2]
Non-small-cell lung cancer	2C25	Approved	[3]
Ovarian disorder	N.A.	Approved	[2]
Ovarian neoplasm	N.A.	Approved	[2]
Pancreatic adenocarcinoma	N.A.	Approved	[2]
Pancreatic ductal carcinoma	2C10.0	Approved	[2]
Pancreatic tumour	2C10	Approved	[2]
Posterior urethra cancer	N.A.	Approved	[2]
Recurrent adult burkitt lymphoma	2A85.6	Approved	[2]
Solid tumour/cancer	2A00-2F9Z	Approved	[4]
Splenic marginal zone lymphoma	N.A.	Approved	[2]
Urethral cancer	2C93	Approved	[2]
Urinary bladder neoplasm	N.A.	Approved	[2]
Middle East Respiratory Syndrome (MERS)	1D64	Preclinical	[5]
Severe acute respiratory syndrome (SARS)	1D65	Preclinical	[5]
Colon cancer	2B90.Z	Investigative	[2]

Gemcitabine Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Ribonucleoside-diphosphate reductase M2 (RRM2)	TTBWDI0	RIR2_HUMAN	Modulator	[14]

Gemcitabine Interacts with 3 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[15]
Multidrug resistance-associated protein 5 (ABCC5)	DTYVM24	MRP5_HUMAN	Substrate	[16]
Concentrative nucleoside transporter 1 (SLC28A1)	DT0EQPW	S28A1_HUMAN	Substrate	[17]

Gemcitabine Interacts with 5 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytidine aminohydrolase (CDA)	DEKEDRC	CDD_HUMAN	Metabolism	[18]
Uridine/cytidine monophosphate kinase (UMPK)	DEMPH4I	KCY_HUMAN	Metabolism	[19]
Cytidine deaminase (cdd)	DETX3A5	CDD_ECOLI	Metabolism	[20]
Cytidine deaminase (cdd)	DEFVABT	CDD_KLEP7	Metabolism	[20]
Cytidine deaminase (cdd)	DEYILK4	E0TLJ6_MYCHH	Metabolism	[21]

Gemcitabine Interacts with 244 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Cytidine deaminase (CDA)	OT3HXP6N	CDD_HUMAN	Affects Response To Substance	[12]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Decreases Expression	[22]
Ribonucleoside-diphosphate reductase subunit M2 (RRM2)	OTOB6J6R	RIR2_HUMAN	Affects Response To Substance	[13]
Ribonucleoside-diphosphate reductase large subunit (RRM1)	OTXGQOR9	RIR1_HUMAN	Affects Response To Substance	[13]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)	OTA1CPBV	TR10B_HUMAN	Increases Expression	[23]
Epidermal growth factor receptor (EGFR)	OTAPLO1S	EGFR_HUMAN	Decreases Expression	[24]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Decreases Expression	[25]
NF-kappa-B inhibitor epsilon (NFKBIE)	OTLAYEL9	IKBE_HUMAN	Affects Expression	[8]
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B)	OTQ4W7MT	TR11B_HUMAN	Increases Expression	[8]
Stearoyl-CoA desaturase (SCD)	OTB1073G	SCD_HUMAN	Increases Expression	[8]
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2)	OT5I4Y9K	PLCB_HUMAN	Decreases Expression	[8]
Insulin-induced gene 1 protein (INSIG1)	OTZF5X1D	INSI1_HUMAN	Increases Expression	[8]
E3 ubiquitin-protein ligase Praja-2 (PJA2)	OT45TMC4	PJA2_HUMAN	Increases Expression	[8]
Interleukin-1 receptor-associated kinase-like 2 (IRAK2)	OT6Y1QZN	IRAK2_HUMAN	Increases Expression	[8]
Bcl-2-like protein 11 (BCL2L11)	OTNQQWFJ	B2L11_HUMAN	Increases Expression	[8]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L)	OTJKOMXE	BNI3L_HUMAN	Increases Expression	[8]
Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP)	OTRNDZXB	HNRPQ_HUMAN	Decreases Expression	[8]
Melanoma-associated antigen C1 (MAGEC1)	OTHMFHH8	MAGC1_HUMAN	Increases Expression	[8]
Liprin-alpha-4 (PPFIA4)	OTWXG0DO	LIPA4_HUMAN	Increases Expression	[8]
Transcription factor Maf (MAF)	OT1GR3IZ	MAF_HUMAN	Increases Expression	[8]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)	OTYG179K	PR15A_HUMAN	Increases Expression	[8]
Krueppel-like factor 8 (KLF8)	OTUC5CDB	KLF8_HUMAN	Increases Expression	[8]
Urokinase-type plasminogen activator (PLAU)	OTX0QGKK	UROK_HUMAN	Increases Expression	[8]
Fibrinogen gamma chain (FGG)	OT5BJSEX	FIBG_HUMAN	Affects Expression	[8]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Increases Expression	[8]
Keratin, type II cytoskeletal 8 (KRT8)	OTTM4X11	K2C8_HUMAN	Decreases Expression	[8]
Growth-regulated alpha protein (CXCL1)	OT3WCTZV	GROA_HUMAN	Increases Expression	[8]
Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1)	OTXOQDSG	IFIT1_HUMAN	Increases Expression	[8]
Transcriptional activator Myb (MYB)	OTJH64IV	MYB_HUMAN	Increases Expression	[8]
Osteopontin (SPP1)	OTJGC23Y	OSTP_HUMAN	Increases Expression	[8]
Endoplasmic reticulum chaperone BiP (HSPA5)	OTFUIRAO	BIP_HUMAN	Increases Expression	[8]
Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3)	OT2HZK5M	GTR3_HUMAN	Increases Expression	[8]
Creatine kinase B-type (CKB)	OTUCKOTT	KCRB_HUMAN	Decreases Expression	[8]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Increases Expression	[8]
Homeobox protein Hox-B2 (HOXB2)	OTTD6HMV	HXB2_HUMAN	Increases Expression	[8]
Fos-related antigen 2 (FOSL2)	OT3MT9HJ	FOSL2_HUMAN	Decreases Expression	[8]
Methylated-DNA--protein-cysteine methyltransferase (MGMT)	OT40A9WH	MGMT_HUMAN	Decreases Expression	[8]
CCAAT/enhancer-binding protein beta (CEBPB)	OTM9MQIA	CEBPB_HUMAN	Increases Expression	[8]
Early growth response protein 1 (EGR1)	OTCP6XGZ	EGR1_HUMAN	Increases Expression	[8]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3)	OTC1UOHP	ATF3_HUMAN	Increases Expression	[8]
C-X-C motif chemokine 2 (CXCL2)	OTEJCYMY	CXCL2_HUMAN	Increases Expression	[8]
C-X-C motif chemokine 3 (CXCL3)	OTSL94KH	CXCL3_HUMAN	Increases Expression	[8]
Endothelin-2 (EDN2)	OTQ7RCPI	EDN2_HUMAN	Decreases Expression	[8]
Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)	OTVLI4DD	TNAP3_HUMAN	Increases Expression	[8]
Diamine acetyltransferase 1 (SAT1)	OT52AU22	SAT1_HUMAN	Increases Expression	[8]
Prostaglandin G/H synthase 1 (PTGS1)	OTHCRLEC	PGH1_HUMAN	Decreases Expression	[8]
G1/S-specific cyclin-D1 (CCND1)	OT8HPTKJ	CCND1_HUMAN	Decreases Expression	[8]
Tumor necrosis factor receptor superfamily member 5 (CD40)	OT5YU2XB	TNR5_HUMAN	Decreases Expression	[8]
Myristoylated alanine-rich C-kinase substrate (MARCKS)	OT7N056G	MARCS_HUMAN	Increases Expression	[8]
Protein EVI2B (EVI2B)	OT98X1OE	EVI2B_HUMAN	Decreases Expression	[8]
Heat shock 70 kDa protein 1-like (HSPA1L)	OTC2V1K6	HS71L_HUMAN	Decreases Expression	[8]
Glutaredoxin-1 (GLRX)	OT0QHTAR	GLRX1_HUMAN	Increases Expression	[8]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Increases Expression	[8]
Nicotinamide N-methyltransferase (NNMT)	OTFM38GU	NNMT_HUMAN	Increases Expression	[8]
B-cell lymphoma 6 protein (BCL6)	OTQAWWO1	BCL6_HUMAN	Increases Expression	[8]
Regulator of G-protein signaling 2 (RGS2)	OT0FSRW7	RGS2_HUMAN	Increases Expression	[8]
Leukemia inhibitory factor receptor (LIFR)	OT36W9O5	LIFR_HUMAN	Increases Expression	[8]
Melanoma-associated antigen 10 (MAGEA10)	OTI4KPYB	MAGAA_HUMAN	Decreases Expression	[8]
Lysophosphatidic acid receptor 6 (LPAR6)	OT4BY3W4	LPAR6_HUMAN	Decreases Expression	[8]
Ras GTPase-activating-like protein IQGAP1 (IQGAP1)	OTZRWTGA	IQGA1_HUMAN	Increases Expression	[8]
Retinaldehyde dehydrogenase 3 (ALDH1A3)	OT1C9NKQ	AL1A3_HUMAN	Increases Expression	[8]
Max-interacting protein 1 (MXI1)	OTUQ9E0D	MXI1_HUMAN	Increases Expression	[8]
ETS translocation variant 1 (ETV1)	OT6PMJIK	ETV1_HUMAN	Increases Expression	[8]
Glypican-3 (GPC3)	OTWS8WSW	GPC3_HUMAN	Increases Expression	[8]
Transcription initiation factor IIA subunit 1 (GTF2A1)	OTWW4PN0	TF2AA_HUMAN	Affects Expression	[8]
Growth arrest-specific protein 1 (GAS1)	OTKJXG52	GAS1_HUMAN	Decreases Expression	[8]
Puromycin-sensitive aminopeptidase (NPEPPS)	OTMENFXR	PSA_HUMAN	Decreases Expression	[8]
Methionine--tRNA ligase, cytoplasmic (MARS1)	OTLJ6MHJ	SYMC_HUMAN	Increases Expression	[8]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)	OTOWDUNT	PTEN_HUMAN	Affects Expression	[8]
Ras-related protein Rab-8A (RAB8A)	OTPB54Y3	RAB8A_HUMAN	Decreases Expression	[8]
Lysozyme C (LYZ)	OTD7H0G6	LYSC_HUMAN	Decreases Expression	[8]
Transforming growth factor beta-2 proprotein (TGFB2)	OTC0TXEP	TGFB2_HUMAN	Increases Expression	[8]
Large ribosomal subunit protein eL37 (RPL37)	OTB6SDZ1	RL37_HUMAN	Increases Expression	[8]
Histone H4 (H4C1)	OTB71W46	H4_HUMAN	Decreases Expression	[8]
C-C motif chemokine 20 (CCL20)	OTUCJY4N	CCL20_HUMAN	Increases Expression	[8]
ADP-ribosylation factor 1 (ARF1)	OT5C4C3L	ARF1_HUMAN	Decreases Expression	[8]
Nuclear factor NF-kappa-B p100 subunit (NFKB2)	OTS231V7	NFKB2_HUMAN	Affects Expression	[8]
Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase , mitochondrial (ALDH6A1)	OT8LCZCT	MMSA_HUMAN	Increases Expression	[8]
Pro-neuregulin-1, membrane-bound isoform (NRG1)	OTZO6F1X	NRG1_HUMAN	Increases Expression	[8]
Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)	OTFH9M73	PTN11_HUMAN	Affects Expression	[8]
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1)	OTG2T749	CP24A_HUMAN	Decreases Expression	[8]
ATP-dependent RNA helicase A (DHX9)	OT5AAOQI	DHX9_HUMAN	Decreases Expression	[8]
Nuclear cap-binding protein subunit 1 (NCBP1)	OTYBR927	NCBP1_HUMAN	Increases Expression	[8]
TP53-binding protein 1 (TP53BP1)	OTL8879S	TP53B_HUMAN	Increases Expression	[8]
Ankyrin-3 (ANK3)	OTJ3IRBP	ANK3_HUMAN	Increases Expression	[8]
TNF receptor-associated factor 1 (TRAF1)	OTTLM5RU	TRAF1_HUMAN	Affects Expression	[8]
PDZK1-interacting protein 1 (PDZK1IP1)	OTWA6M5K	PDZ1I_HUMAN	Increases Expression	[8]
Treacle protein (TCOF1)	OT4BOYTM	TCOF_HUMAN	Decreases Expression	[8]
Baculoviral IAP repeat-containing protein 3 (BIRC3)	OT3E95KB	BIRC3_HUMAN	Affects Expression	[8]
Baculoviral IAP repeat-containing protein 2 (BIRC2)	OTFXFREP	BIRC2_HUMAN	Increases Expression	[8]
Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1)	OTD1KRKO	DYHC1_HUMAN	Decreases Expression	[8]
Enhancer of filamentation 1 (NEDD9)	OTGCFN4M	CASL_HUMAN	Increases Expression	[8]
Interferon regulatory factor 3 (IRF3)	OT81U8ME	IRF3_HUMAN	Decreases Expression	[8]
FXYD domain-containing ion transport regulator 3 (FXYD3)	OT9PPRHE	FXYD3_HUMAN	Increases Expression	[8]
Ankyrin repeat domain-containing protein 1 (ANKRD1)	OTHJ7JV9	ANKR1_HUMAN	Increases Expression	[8]
Disks large homolog 2 (DLG2)	OTQ3BD8U	DLG2_HUMAN	Increases Expression	[8]
Cysteine and glycine-rich protein 2 (CSRP2)	OT4SW0HI	CSRP2_HUMAN	Increases Expression	[8]
Cyclin-G2 (CCNG2)	OTII38K2	CCNG2_HUMAN	Increases Expression	[8]
Golgi-associated kinase 1B (GASK1B)	OT2HPHEI	GAK1B_HUMAN	Decreases Expression	[8]
SUZ domain-containing protein 1 (SZRD1)	OTJMEJWT	SZRD1_HUMAN	Decreases Expression	[8]
Leucine-rich repeat-containing protein 28 (LRRC28)	OTFTT6VN	LRC28_HUMAN	Increases Expression	[8]
Mitochondrial basic amino acids transporter (SLC25A29)	OT09PIFE	S2529_HUMAN	Increases Expression	[8]
Equilibrative nucleobase transporter 1 (SLC43A3)	OTR60ZLA	S43A3_HUMAN	Decreases Expression	[8]
Proprotein convertase subtilisin/kexin type 9 (PCSK9)	OTI0DU9Y	PCSK9_HUMAN	Increases Expression	[8]
E3 ubiquitin-protein ligase RNF149 (RNF149)	OT6SBKQV	RN149_HUMAN	Increases Expression	[8]
F-box only protein 25 (FBXO25)	OTDFA7F4	FBX25_HUMAN	Increases Expression	[8]
Solute carrier family 2, facilitated glucose transporter member 14 (SLC2A14)	OTBFIOVY	GTR14_HUMAN	Increases Expression	[8]
Membrane progestin receptor beta (PAQR8)	OTGZ8W9F	PAQR8_HUMAN	Increases Expression	[8]
Nuclear receptor subfamily 4 group A member 3 (NR4A3)	OTPBE9R1	NR4A3_HUMAN	Increases Expression	[8]
La-related protein 4B (LARP4B)	OT2HI0QE	LAR4B_HUMAN	Increases Expression	[8]
Collagen triple helix repeat-containing protein 1 (CTHRC1)	OTV88X2G	CTHR1_HUMAN	Increases Expression	[8]
BTB/POZ domain-containing protein KCTD12 (KCTD12)	OTPYKT4Z	KCD12_HUMAN	Decreases Expression	[8]
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (MAGI1)	OTMV4ASV	MAGI1_HUMAN	Increases Expression	[8]
Sialidase-1 (NEU1)	OTH9BY8Y	NEUR1_HUMAN	Increases Expression	[8]
Galactosylceramide sulfotransferase (GAL3ST1)	OTSFFZRD	G3ST1_HUMAN	Decreases Expression	[8]
Junctional adhesion molecule C (JAM3)	OTX0F9QL	JAM3_HUMAN	Decreases Expression	[8]
SLIT and NTRK-like protein 2 (SLITRK2)	OTPVI22J	SLIK2_HUMAN	Increases Expression	[8]
Anaphase-promoting complex subunit 1 (ANAPC1)	OT2YY35L	APC1_HUMAN	Increases Expression	[8]
Anthrax toxin receptor 1 (ANTXR1)	OT5W1GPC	ANTR1_HUMAN	Affects Expression	[8]
Ras-related GTP-binding protein D (RRAGD)	OTXLVWAH	RRAGD_HUMAN	Increases Expression	[8]
DNA damage-inducible transcript 4 protein (DDIT4)	OTHY8SY4	DDIT4_HUMAN	Affects Expression	[8]
Intersectin-2 (ITSN2)	OT8S0OO8	ITSN2_HUMAN	Increases Expression	[8]
Probable ribosome biogenesis protein RLP24 (RSL24D1)	OT6KI56F	RLP24_HUMAN	Increases Expression	[8]
Transcription elongation factor A protein-like 9 (TCEAL9)	OT4UHDB5	TCAL9_HUMAN	Increases Expression	[8]
Histone deacetylase 9 (HDAC9)	OTO8O0LF	HDAC9_HUMAN	Increases Expression	[8]
Phosphoserine aminotransferase (PSAT1)	OTVV1YV9	SERC_HUMAN	Increases Expression	[8]
Chloride intracellular channel protein 4 (CLIC4)	OT6KTPKD	CLIC4_HUMAN	Increases Expression	[8]
Alpha-2-macroglobulin (A2M)	OTFTX90K	A2MG_HUMAN	Increases Expression	[9]
Pro-epidermal growth factor (EGF)	OTANRJ0L	EGF_HUMAN	Decreases Expression	[9]
Insulin (INS)	OTZ85PDU	INS_HUMAN	Increases Expression	[9]
Lymphotoxin-alpha (LTA)	OTUC3S76	TNFB_HUMAN	Increases Expression	[9]
Tumor necrosis factor (TNF)	OT4IE164	TNFA_HUMAN	Increases Expression	[9]
Interferon gamma (IFNG)	OTXG9JM7	IFNG_HUMAN	Decreases Expression	[9]
Interleukin-1 alpha (IL1A)	OTPSGILV	IL1A_HUMAN	Decreases Expression	[9]
Interleukin-1 beta (IL1B)	OT0DWXXB	IL1B_HUMAN	Decreases Expression	[9]
Serum amyloid P-component (APCS)	OT76JZ8Z	SAMP_HUMAN	Decreases Expression	[9]
Beta-2-glycoprotein 1 (APOH)	OTFMUX6O	APOH_HUMAN	Increases Expression	[9]
Alpha-fetoprotein (AFP)	OT9GG3ZI	FETA_HUMAN	Decreases Expression	[9]
Granulocyte-macrophage colony-stimulating factor (CSF2)	OT1M7D28	CSF2_HUMAN	Decreases Expression	[9]
Interleukin-4 (IL4)	OTOXBWAU	IL4_HUMAN	Decreases Expression	[9]
Myeloperoxidase (MPO)	OTOOXLIN	PERM_HUMAN	Increases Expression	[9]
Endothelin-1 (EDN1)	OTZCACEG	EDN1_HUMAN	Decreases Expression	[9]
Intercellular adhesion molecule 1 (ICAM1)	OTTOIX77	ICAM1_HUMAN	Decreases Expression	[9]
Stromelysin-1 (MMP3)	OTGBI74Z	MMP3_HUMAN	Decreases Expression	[9]
Coagulation factor VII (F7)	OTGNJ97M	FA7_HUMAN	Decreases Expression	[9]
Fibroblast growth factor 2 (FGF2)	OT7YUJ9F	FGF2_HUMAN	Increases Expression	[9]
Granulocyte colony-stimulating factor (CSF3)	OT9GC6TP	CSF3_HUMAN	Decreases Expression	[9]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Decreases Expression	[9]
C-C motif chemokine 3 (CCL3)	OTW2H3ND	CCL3_HUMAN	Increases Expression	[9]
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Decreases Expression	[9]
Prostatic acid phosphatase (ACP3)	OTSIM0YG	PPAP_HUMAN	Decreases Expression	[9]
Kit ligand (KITLG)	OTB9AVQ4	SCF_HUMAN	Decreases Expression	[9]
Interleukin-10 (IL10)	OTIRFRXC	IL10_HUMAN	Decreases Expression	[9]
Brain-derived neurotrophic factor (BDNF)	OTLGH7EW	BDNF_HUMAN	Decreases Expression	[9]
CD40 ligand (CD40LG)	OT75Z6A6	CD40L_HUMAN	Decreases Expression	[9]
Interleukin-13 (IL13)	OTI4YS3Y	IL13_HUMAN	Increases Expression	[9]
Thrombopoietin (THPO)	OTO73DZ2	TPO_HUMAN	Increases Expression	[9]
Interleukin-15 (IL15)	OTQSYWQS	IL15_HUMAN	Decreases Expression	[9]
Leptin (LEP)	OT5Q7ODW	LEP_HUMAN	Decreases Expression	[9]
Pappalysin-1 (PAPPA)	OTTTG9PG	PAPP1_HUMAN	Decreases Expression	[9]
Pro-interleukin-16 (IL16)	OTZ2MO6B	IL16_HUMAN	Increases Expression	[9]
Adiponectin (ADIPOQ)	OTNX23LE	ADIPO_HUMAN	Increases Expression	[9]
Aldehyde dehydrogenase 1A1 (ALDH1A1)	OTCUWZKB	AL1A1_HUMAN	Decreases Expression	[26]
Neurogenic locus notch homolog protein 1 (NOTCH1)	OTI1WADQ	NOTC1_HUMAN	Increases Expression	[26]
Proto-oncogene c-Rel (REL)	OTTCKMAC	REL_HUMAN	Decreases Expression	[26]
Telomerase reverse transcriptase (TERT)	OT085VVA	TERT_HUMAN	Decreases Activity	[27]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Decreases Expression	[28]
Nuclear protein 1 (NUPR1)	OT4FU8C0	NUPR1_HUMAN	Decreases Expression	[29]
Collagen alpha-1(I) chain (COL1A1)	OTI31178	CO1A1_HUMAN	Decreases Expression	[30]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Increases Expression	[31]
Insulin-like growth factor 1 receptor (IGF1R)	OTXJIF13	IGF1R_HUMAN	Decreases Expression	[24]
Heme oxygenase 1 (HMOX1)	OTC1W6UX	HMOX1_HUMAN	Increases Expression	[32]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Increases Cleavage	[33]
Zinc finger protein GLI2 (GLI2)	OTIRV97L	GLI2_HUMAN	Affects Expression	[24]
Clusterin (CLU)	OTQGG0JM	CLUS_HUMAN	Increases Expression	[34]
G2/mitotic-specific cyclin-B1 (CCNB1)	OT19S7E5	CCNB1_HUMAN	Decreases Expression	[24]
Serine/threonine-protein kinase B-raf (BRAF)	OT7S81XQ	BRAF_HUMAN	Decreases Expression	[24]
NAD(P)H dehydrogenase 1 (NQO1)	OTZGGIVK	NQO1_HUMAN	Increases Expression	[32]
CD44 antigen (CD44)	OT9TTJ41	CD44_HUMAN	Affects Expression	[22]
Histone H2AX (H2AX)	OT18UX57	H2AX_HUMAN	Increases Expression	[35]
Insulin-like growth factor-binding protein 3 (IGFBP3)	OTIX63TX	IBP3_HUMAN	Affects Expression	[24]
Cannabinoid receptor 1 (CNR1)	OTEALO6G	CNR1_HUMAN	Increases Expression	[36]
Tumor necrosis factor receptor superfamily member 6 (FAS)	OTP9XG86	TNR6_HUMAN	Increases Expression	[37]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Increases Phosphorylation	[25]
Aryl hydrocarbon receptor nuclear translocator (ARNT)	OTMSIEZY	ARNT_HUMAN	Increases Expression	[24]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Increases Phosphorylation	[25]
14-3-3 protein sigma (SFN)	OTLJCZ1U	1433S_HUMAN	Increases Methylation	[38]
Cannabinoid receptor 2 (CNR2)	OTYP9P43	CNR2_HUMAN	Increases Expression	[36]
Catenin beta-1 (CTNNB1)	OTZ932A3	CTNB1_HUMAN	Increases Expression	[39]
Breast cancer type 1 susceptibility protein (BRCA1)	OT5BN6VH	BRCA1_HUMAN	Increases Expression	[24]
Signal transducer and activator of transcription 3 (STAT3)	OTAAGKYZ	STAT3_HUMAN	Decreases Activity	[40]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Increases Activity	[41]
Proliferation marker protein Ki-67 (MKI67)	OTA8N1QI	KI67_HUMAN	Decreases Expression	[28]
Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)	OTI2OREX	MP2K3_HUMAN	Increases Phosphorylation	[42]
Transcription factor SOX-2 (SOX2)	OTFAWCAU	SOX2_HUMAN	Increases Expression	[39]
Glycogen synthase kinase-3 beta (GSK3B)	OTL3L14B	GSK3B_HUMAN	Increases Phosphorylation	[43]
Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6)	OTK13JKC	MP2K6_HUMAN	Increases Phosphorylation	[42]
Serine/threonine-protein kinase PLK1 (PLK1)	OTRZX45T	PLK1_HUMAN	Decreases Expression	[24]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Increases Activity	[41]
BH3-interacting domain death agonist (BID)	OTOSHSHU	BID_HUMAN	Increases Cleavage	[44]
C-X-C chemokine receptor type 4 (CXCR4)	OTUFSBX2	CXCR4_HUMAN	Affects Expression	[24]
E3 ubiquitin-protein ligase Mdm2 (MDM2)	OTOVXARF	MDM2_HUMAN	Decreases Expression	[24]
POU domain, class 5, transcription factor 1 (POU5F1)	OTDHHN7O	PO5F1_HUMAN	Decreases Expression	[22]
Transcription factor p65 (RELA)	OTUJP9CN	TF65_HUMAN	Increases Expression	[45]
Regenerating islet-derived protein 3-alpha (REG3A)	OT0BVQRB	REG3A_HUMAN	Decreases Expression	[43]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Decreases Expression	[25]
Protein patched homolog 1 (PTCH1)	OTMG07H5	PTC1_HUMAN	Affects Expression	[24]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Increases Activity	[41]
Sonic hedgehog protein (SHH)	OTOG2BXF	SHH_HUMAN	Decreases Expression	[24]
Nuclear factor erythroid 2-related factor 2 (NFE2L2)	OT0HENJ5	NF2L2_HUMAN	Increases Expression	[32]
Tumor protein p53-inducible nuclear protein 1 (TP53INP1)	OT2363Z9	T53I1_HUMAN	Increases Expression	[43]
Protein smoothened (SMO)	OTXXE208	SMO_HUMAN	Increases Expression	[39]
Homeobox protein NANOG (NANOG)	OTUEY1FM	NANOG_HUMAN	Decreases Expression	[39]
Axin-2 (AXIN2)	OTRMGQNU	AXIN2_HUMAN	Affects Expression	[24]
3',5'-cyclic-AMP phosphodiesterase 4D (PDE4D)	OT1RWFV0	PDE4D_HUMAN	Increases ADR	[46]
Focal adhesion kinase 1 (PTK2)	OT3Q1JDY	FAK1_HUMAN	Decreases Response To Substance	[47]
RAC-alpha serine/threonine-protein kinase (AKT1)	OT8H2YY7	AKT1_HUMAN	Affects Response To Substance	[48]
Splicing factor 45 (RBM17)	OT9ROJCL	SPF45_HUMAN	Decreases Response To Substance	[49]
Hypoxia-inducible factor 1-alpha (HIF1A)	OTADSC03	HIF1A_HUMAN	Affects Response To Substance	[50]
Neuropilin-1 (NRP1)	OTCGULYV	NRP1_HUMAN	Decreases Response To Substance	[51]
Oxysterol-binding protein 2 (OSBP2)	OTDGLB4J	OSBP2_HUMAN	Increases ADR	[46]
Proto-oncogene tyrosine-protein kinase Src (SRC)	OTETYX40	SRC_HUMAN	Decreases Response To Substance	[52]
Equilibrative nucleoside transporter 3 (SLC29A3)	OTGLX8XU	S29A3_HUMAN	Affects Transport	[53]
Probable ATP-dependent RNA helicase DDX53 (DDX53)	OTHK3EGZ	DDX53_HUMAN	Affects Response To Substance	[54]
Amphiregulin (AREG)	OTJFOR67	AREG_HUMAN	Decreases Response To Substance	[55]
Pyruvate kinase PKM (PKM)	OTLHHMC2	KPYM_HUMAN	Affects Response To Substance	[28]
Equilibrative nucleoside transporter 1 (SLC29A1)	OTLOOZZS	S29A1_HUMAN	Increases Response To Substance	[56]
Alpha-protein kinase 3 (ALPK3)	OTLUYSMO	ALPK3_HUMAN	Increases ADR	[46]
Transcription factor AP-2-alpha (TFAP2A)	OTMYT3NK	AP2A_HUMAN	Increases Response To Substance	[57]
Death-associated protein kinase 1 (DAPK1)	OTNCNUCO	DAPK1_HUMAN	Increases ADR	[58]
Cytochrome c oxidase subunit 3 (COX3)	OTNNGBYJ	COX3_HUMAN	Decreases Response To Substance	[59]
Cyclin-dependent kinase inhibitor 1B (CDKN1B)	OTNY5LLZ	CDN1B_HUMAN	Decreases Response To Substance	[60]
Receptor tyrosine-protein kinase erbB-2 (ERBB2)	OTOAUNCK	ERBB2_HUMAN	Increases ADR	[61]
Myc proto-oncogene protein (MYC)	OTPV5LUK	MYC_HUMAN	Affects Response To Substance	[62]
3-phosphoinositide-dependent protein kinase 1 (PDPK1)	OTT09ZVP	PDPK1_HUMAN	Decreases Response To Substance	[63]
Nucleophosmin (NPM1)	OTTBYYT0	NPM_HUMAN	Decreases Response To Substance	[64]
Serine/threonine-protein kinase SMG1 (SMG1)	OTTS3SXE	SMG1_HUMAN	Decreases Response To Substance	[65]
ATP-dependent DNA helicase PIF1 (PIF1)	OTUHKKVP	PIF1_HUMAN	Decreases Response To Substance	[35]
Transforming growth factor beta-1 proprotein (TGFB1)	OTV5XHVH	TGFB1_HUMAN	Decreases Response To Substance	[66]
Ribonucleoside-diphosphate reductase large subunit (RRM1)	OTXGQOR9	RIR1_HUMAN	Increases ADR	[67]
Olfactory receptor 4D6 (OR4D6)	OTXJKUT1	OR4D6_HUMAN	Affects Response To Substance	[54]
PDZ domain-containing protein GIPC1 (GIPC1)	OTXLVCPJ	GIPC1_HUMAN	Affects Response To Substance	[68]
Integrin-linked protein kinase (ILK)	OTYG2FD1	ILK_HUMAN	Affects Response To Substance	[48]
Poly polymerase 2 (PARP2)	OTYL81ZI	PARP2_HUMAN	Decreases Response To Substance	[69]

Indication(s) of Irinotecan

Disease Entry	ICD 11	Status	REF
Adenocarcinoma	2D40	Approved	[6]
Advanced cancer	2A00-2F9Z	Approved	[6]
Appendiceal neoplasm	N.A.	Approved	[6]
Astrocytoma	2A00.0Y	Approved	[6]
Brain glioma	N.A.	Approved	[6]
Colon adenocarcinoma	N.A.	Approved	[6]
Colorectal cancer	2B91.Z	Approved	[7]
Endocrine gland neoplasm	N.A.	Approved	[6]
Kidney neoplasm	N.A.	Approved	[6]
Metastasis from malignant tumor of colon	N.A.	Approved	[6]
Peritoneal neoplasm	N.A.	Approved	[6]
Rectal adenocarcinoma	2B92	Approved	[6]
Rectal neoplasm	N.A.	Approved	[6]
Rectum mucinous adenocarcinoma	N.A.	Approved	[6]
Adult glioblastoma	N.A.	Investigative	[6]
Colon cancer	2B90.Z	Investigative	[6]
Colon mucinous adenocarcinoma	N.A.	Investigative	[6]
Diarrhea	ME05.1	Investigative	[6]
Gastric cancer	2B72	Investigative	[6]
Neuroblastoma	2D11.2	Investigative	[6]

Irinotecan Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
DNA topoisomerase I (TOP1)	TTGTQHC	TOP1_HUMAN	Modulator	[14]

Irinotecan Interacts with 6 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
Multidrug resistance-associated protein 1 (ABCC1)	DTSYQGK	MRP1_HUMAN	Substrate	[78]
Multidrug resistance-associated protein 2 (ABCC2)	DTFI42L	MRP2_HUMAN	Substrate	[79]
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[79]
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[80]
Multidrug resistance-associated protein 4 (ABCC4)	DTCSGPB	MRP4_HUMAN	Substrate	[81]
Multidrug resistance-associated protein 5 (ABCC5)	DTYVM24	MRP5_HUMAN	Substrate	[82]

Irinotecan Interacts with 8 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[83]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Metabolism	[84]
Cytochrome P450 3A7 (CYP3A7)	DERD86B	CP3A7_HUMAN	Metabolism	[85]
Cytochrome P450 2B6 (CYP2B6)	DEPKLMQ	CP2B6_HUMAN	Metabolism	[86]
Carboxylesterase 1 (CES1)	DEB30C5	EST1_HUMAN	Metabolism	[83]
Carboxylesterase 3 (CES3)	DEMI4VE	EST3_HUMAN	Metabolism	[87]
Carboxylesterase 2 (CES2)	DETHCPD	EST2_HUMAN	Metabolism	[87]
Beta-glucuronidase (uidA)	DE9RA0I	BGLR_ECOLI	Metabolism	[88]

Irinotecan Interacts with 469 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Cocaine esterase (CES2)	OTC647SQ	EST2_HUMAN	Increases Expression	[89]
Carboxylesterase 3 (CES3)	OT00OP43	EST3_HUMAN	Increases Hydrolysis	[87]
Cytochrome P450 3A4 (CYP3A4)	OTQGYY83	CP3A4_HUMAN	Increases Response To Substance	[90]
Liver carboxylesterase 1 (CES1)	OT9L0LR8	EST1_HUMAN	Increases Response To Substance	[90]
Multidrug resistance-associated protein 1 (ABCC1)	OTGUN89S	MRP1_HUMAN	Decreases Expression	[73]
ATP-binding cassette sub-family C member 2 (ABCC2)	OTJSIGV5	MRP2_HUMAN	Decreases Response To Substance	[91]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)	OTW8V2V1	ABCG2_HUMAN	Increases Response To Substance	[90]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Decreases Response To Substance	[91]
Solute carrier organic anion transporter family member 1B1 (SLCO1B1)	OTNEN8QK	SO1B1_HUMAN	Increases ADR	[92]
Thiopurine S-methyltransferase (TPMT)	OTFOX70W	TPMT_HUMAN	Increases Expression	[73]
Cytochrome P450 2A6 (CYP2A6)	OT52TWG3	CP2A6_HUMAN	Decreases Activity	[93]
Cytochrome P450 2C9 (CYP2C9)	OTGLBN29	CP2C9_HUMAN	Decreases Activity	[93]
Annexin A2 (ANXA2)	OTFNS0CC	ANXA2_HUMAN	Increases Expression	[94]
Diamine acetyltransferase 1 (SAT1)	OT52AU22	SAT1_HUMAN	Increases Expression	[94]
FXYD domain-containing ion transport regulator 3 (FXYD3)	OT9PPRHE	FXYD3_HUMAN	Increases Expression	[94]
B-cell CLL/lymphoma 9 protein (BCL9)	OTRBIPR4	BCL9_HUMAN	Increases Expression	[72]
Chromodomain-helicase-DNA-binding protein 1 (CHD1)	OT9R9G0H	CHD1_HUMAN	Decreases Expression	[72]
Prostaglandin E synthase (PTGES)	OTB7YQFU	PTGES_HUMAN	Increases Expression	[72]
tRNA (TRDMT1)	OTAYQ8ZF	TRDMT_HUMAN	Decreases Expression	[72]
Guanine nucleotide exchange factor DBS (MCF2L)	OTEURA8N	MCF2L_HUMAN	Decreases Expression	[72]
Fanconi anemia group G protein (FANCG)	OT7MC8TZ	FANCG_HUMAN	Increases Expression	[72]
Monocarboxylate transporter 5 (SLC16A4)	OT1YXBKC	MOT5_HUMAN	Decreases Expression	[72]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Decreases Expression	[72]
Prominin-1 (PROM1)	OTBHV8NX	PROM1_HUMAN	Decreases Expression	[72]
A-kinase anchor protein 10, mitochondrial (AKAP10)	OTPNFTOU	AKA10_HUMAN	Decreases Expression	[72]
Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1)	OT80DZMT	BUB1_HUMAN	Decreases Expression	[72]
Hyaluronan mediated motility receptor (HMMR)	OT4M0JTZ	HMMR_HUMAN	Decreases Expression	[72]
G2/mitotic-specific cyclin-B2 (CCNB2)	OTIEXTDK	CCNB2_HUMAN	Decreases Expression	[72]
Heat shock 70 kDa protein 4L (HSPA4L)	OT181WZB	HS74L_HUMAN	Decreases Expression	[72]
Aldehyde dehydrogenase 1A1 (ALDH1A1)	OTCUWZKB	AL1A1_HUMAN	Decreases Expression	[72]
Protein c-Fos (FOS)	OTJBUVWS	FOS_HUMAN	Increases Expression	[72]
Interleukin-1 beta (IL1B)	OT0DWXXB	IL1B_HUMAN	Increases Expression	[72]
Lactotransferrin (LTF)	OT8JWCZ0	TRFL_HUMAN	Decreases Expression	[72]
Histidine-rich glycoprotein (HRG)	OTPLUFOG	HRG_HUMAN	Increases Expression	[72]
Thy-1 membrane glycoprotein (THY1)	OTVONVTB	THY1_HUMAN	Increases Expression	[72]
Insulin-like growth factor I (IGF1)	OTIIZR61	IGF1_HUMAN	Increases Expression	[72]
Myeloperoxidase (MPO)	OTOOXLIN	PERM_HUMAN	Decreases Expression	[72]
Transcription factor Jun (JUN)	OTCYBO6X	JUN_HUMAN	Increases Expression	[72]
Cyclin-dependent kinase 1 (CDK1)	OTW1SC2N	CDK1_HUMAN	Decreases Expression	[72]
Integrin alpha-V (ITGAV)	OTAM7JTR	ITAV_HUMAN	Decreases Expression	[72]
Annexin A6 (ANXA6)	OT9KIQ0Y	ANXA6_HUMAN	Increases Expression	[72]
Fibroblast growth factor 2 (FGF2)	OT7YUJ9F	FGF2_HUMAN	Increases Expression	[72]
Sulfotransferase 1A3 (SULT1A4)	OTHJ8WWV	ST1A3_HUMAN	Increases Expression	[72]
Serine/threonine-protein kinase A-Raf (ARAF)	OTZJ0FNO	ARAF_HUMAN	Increases Expression	[72]
DNA topoisomerase 2-alpha (TOP2A)	OT6LPS08	TOP2A_HUMAN	Decreases Expression	[72]
Collagen alpha-1(VI) chain (COL6A1)	OTYKSCOB	CO6A1_HUMAN	Increases Expression	[72]
Keratin, type II cytoskeletal 5 (KRT5)	OTVGI9HT	K2C5_HUMAN	Decreases Expression	[72]
Nidogen-1 (NID1)	OTKLBLS6	NID1_HUMAN	Increases Expression	[72]
Matrix metalloproteinase-9 (MMP9)	OTB2QDAV	MMP9_HUMAN	Increases Expression	[72]
Protein C-ets-2 (ETS2)	OTPVHOZ7	ETS2_HUMAN	Increases Expression	[72]
Histone H2AX (H2AX)	OT18UX57	H2AX_HUMAN	Increases Expression	[72]
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (PPP3CB)	OTEGNEHW	PP2BB_HUMAN	Decreases Expression	[72]
SH2/SH3 adapter protein NCK1 (NCK1)	OTKYZ4OP	NCK1_HUMAN	Decreases Expression	[72]
Early growth response protein 1 (EGR1)	OTCP6XGZ	EGR1_HUMAN	Increases Expression	[72]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3)	OTC1UOHP	ATF3_HUMAN	Increases Expression	[72]
Cyclin-A2 (CCNA2)	OTPHHYZJ	CCNA2_HUMAN	Decreases Expression	[72]
Interferon-induced GTP-binding protein Mx2 (MX2)	OT05NF37	MX2_HUMAN	Decreases Expression	[72]
Integrin alpha-X (ITGAX)	OTOGIMHE	ITAX_HUMAN	Increases Expression	[72]
Myelin and lymphocyte protein (MAL)	OTBM30SW	MAL_HUMAN	Increases Expression	[72]
Glutathione peroxidase 3 (GPX3)	OT6PK94R	GPX3_HUMAN	Increases Expression	[72]
5-aminolevulinate synthase, erythroid-specific, mitochondrial (ALAS2)	OTJXOUCL	HEM0_HUMAN	Increases Expression	[72]
Receptor-type tyrosine-protein phosphatase delta (PTPRD)	OTZPJ3GX	PTPRD_HUMAN	Increases Expression	[72]
Trans-acting T-cell-specific transcription factor GATA-3 (GATA3)	OTGP7D5Y	GATA3_HUMAN	Decreases Expression	[72]
Adenomatous polyposis coli protein (APC)	OTKV0TIK	APC_HUMAN	Decreases Expression	[72]
Retinoblastoma-like protein 1 (RBL1)	OTDEBFYC	RBL1_HUMAN	Decreases Expression	[72]
AT-rich interactive domain-containing protein 4A (ARID4A)	OT1XKBZ0	ARI4A_HUMAN	Decreases Expression	[72]
M-phase inducer phosphatase 2 (CDC25B)	OT12MSRY	MPIP2_HUMAN	Decreases Expression	[72]
Syndecan-4 (SDC4)	OTKUVUGZ	SDC4_HUMAN	Increases Expression	[72]
C-C chemokine receptor type 1 (CCR1)	OT4FC783	CCR1_HUMAN	Increases Expression	[72]
G-protein coupled receptor 183 (GPR183)	OTRILX7G	GP183_HUMAN	Increases Expression	[72]
CD70 antigen (CD70)	OTHB2AL1	CD70_HUMAN	Increases Expression	[72]
T-lymphocyte activation antigen CD80 (CD80)	OTJBLUQE	CD80_HUMAN	Increases Expression	[72]
Dual specificity protein kinase TTK (TTK)	OTBY1Z5H	TTK_HUMAN	Decreases Expression	[72]
DNA replication licensing factor MCM4 (MCM4)	OT19PNNG	MCM4_HUMAN	Decreases Expression	[72]
Replication factor C subunit 3 (RFC3)	OT1MS7AO	RFC3_HUMAN	Decreases Expression	[72]
Cyclin-F (CCNF)	OTJFVU43	CCNF_HUMAN	Decreases Expression	[72]
Transcription factor ETV6 (ETV6)	OTCZMG61	ETV6_HUMAN	Decreases Expression	[72]
DNA mismatch repair protein Msh2 (MSH2)	OT10H1AB	MSH2_HUMAN	Decreases Expression	[72]
Hydroxycarboxylic acid receptor 3 (HCAR3)	OTJBHLX0	HCAR3_HUMAN	Increases Expression	[72]
Centromere protein F (CENPF)	OT7AG0SW	CENPF_HUMAN	Decreases Expression	[72]
Caspase-4 (CASP4)	OTVQTV1L	CASP4_HUMAN	Decreases Expression	[72]
5-formyltetrahydrofolate cyclo-ligase (MTHFS)	OTZ39JNR	MTHFS_HUMAN	Decreases Expression	[72]
Protein Tob1 (TOB1)	OTNW949D	TOB1_HUMAN	Increases Expression	[72]
C-C chemokine receptor type 6 (CCR6)	OT61JMYX	CCR6_HUMAN	Decreases Expression	[72]
Serine/threonine-protein kinase Nek2 (NEK2)	OT1H27HO	NEK2_HUMAN	Decreases Expression	[72]
Serine/threonine-protein kinase PLK1 (PLK1)	OTRZX45T	PLK1_HUMAN	Decreases Expression	[72]
Protein FosB (FOSB)	OTW6C05J	FOSB_HUMAN	Increases Expression	[72]
UV excision repair protein RAD23 homolog B (RAD23B)	OT0PGOG3	RD23B_HUMAN	Decreases Expression	[72]
Sestrin-2 (SESN2)	OT889IXY	SESN2_HUMAN	Increases Expression	[72]
Neutrophil defensin 1 (DEFA1)	OT5N1B9B	DEF1_HUMAN	Decreases Expression	[72]
Ras-related C3 botulinum toxin substrate 3 (RAC3)	OT2RE7A7	RAC3_HUMAN	Increases Expression	[72]
Tumor necrosis factor-inducible gene 6 protein (TNFAIP6)	OT1SLUZH	TSG6_HUMAN	Decreases Expression	[72]
E3 ubiquitin-protein ligase Mdm2 (MDM2)	OTOVXARF	MDM2_HUMAN	Increases Expression	[72]
Runt-related transcription factor 1 (RUNX1)	OTU7J84H	RUNX1_HUMAN	Decreases Expression	[72]
Transcription factor Spi-B (SPIB)	OTO4YKYI	SPIB_HUMAN	Increases Expression	[72]
Myocyte-specific enhancer factor 2B (MEF2B)	OT880SE6	MEF2B_HUMAN	Increases Expression	[72]
DNA-binding protein inhibitor ID-2 (ID2)	OT0U1D53	ID2_HUMAN	Decreases Expression	[72]
Dual specificity protein phosphatase 2 (DUSP2)	OTH54FMR	DUS2_HUMAN	Increases Expression	[72]
3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B)	OTOA8WU2	PDE4B_HUMAN	Decreases Expression	[72]
Regulator of G-protein signaling 1 (RGS1)	OTGXJYMG	RGS1_HUMAN	Increases Expression	[72]
Dystrophia myotonica WD repeat-containing protein (DMWD)	OT0CBZ6F	DMWD_HUMAN	Increases Expression	[72]
Histone acetyltransferase p300 (EP300)	OTL8QJDX	EP300_HUMAN	Decreases Expression	[72]
Dihydropyrimidine dehydrogenase (DPYD)	OTWRF2NR	DPYD_HUMAN	Decreases Expression	[72]
Tyrosine-protein phosphatase non-receptor type 13 (PTPN13)	OTESFZSO	PTN13_HUMAN	Decreases Expression	[72]
Rho GTPase-activating protein 5 (ARHGAP5)	OTOQELUN	RHG05_HUMAN	Decreases Expression	[72]
MAL-like protein (MALL)	OTKGZ89D	MALL_HUMAN	Increases Expression	[72]
TNF receptor-associated factor 1 (TRAF1)	OTTLM5RU	TRAF1_HUMAN	Decreases Expression	[72]
Mitotic spindle assembly checkpoint protein MAD2A (MAD2L1)	OTXNGZCG	MD2L1_HUMAN	Decreases Expression	[72]
Cyclin-dependent kinase 5 activator 2 (CDK5R2)	OTNUTLPU	CD5R2_HUMAN	Increases Expression	[72]
Centromere protein R (ITGB3BP)	OT6Q7GR3	CENPR_HUMAN	Decreases Expression	[72]
Dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A)	OTPLXCDN	DYR1A_HUMAN	Decreases Expression	[72]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)	OTXEE550	APR_HUMAN	Increases Expression	[72]
Krueppel-like factor 9 (KLF9)	OTBFEJRQ	KLF9_HUMAN	Increases Expression	[72]
Cyclin-dependent kinase 13 (CDK13)	OT3P7JF1	CDK13_HUMAN	Decreases Expression	[72]
Protein Tob2 (TOB2)	OTEEHL60	TOB2_HUMAN	Increases Expression	[72]
Serine/threonine-protein kinase 38 (STK38)	OTKMYCYR	STK38_HUMAN	Increases Expression	[72]
Retinoblastoma-binding protein 5 (RBBP5)	OT12W2MK	RBBP5_HUMAN	Decreases Expression	[72]
Receptor tyrosine-protein kinase erbB-4 (ERBB4)	OT9L6C41	ERBB4_HUMAN	Increases Expression	[72]
Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF2)	OTRHB9SR	NHRF2_HUMAN	Increases Expression	[72]
Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD)	OTBOSJHO	TRADD_HUMAN	Increases Expression	[72]
Nuclear receptor coactivator 1 (NCOA1)	OTLIUJQD	NCOA1_HUMAN	Increases Expression	[72]
Tubulin-specific chaperone C (TBCC)	OTBF0X8R	TBCC_HUMAN	Increases Expression	[72]
Cyclin-dependent kinase inhibitor 3 (CDKN3)	OTBE3H07	CDKN3_HUMAN	Decreases Expression	[72]
Receptor-type tyrosine-protein phosphatase-like N (PTPRN)	OTAP7NOL	PTPRN_HUMAN	Increases Expression	[72]
B-cell CLL/lymphoma 7 protein family member A (BCL7A)	OTYFUJTP	BCL7A_HUMAN	Increases Expression	[72]
Transmembrane protein 41B (TMEM41B)	OTW0B0KS	TM41B_HUMAN	Decreases Expression	[72]
Transcription initiation factor TFIID subunit 2 (TAF2)	OTTIGJ9M	TAF2_HUMAN	Decreases Expression	[72]
DNA cross-link repair 1A protein (DCLRE1A)	OT68PVSD	DCR1A_HUMAN	Decreases Expression	[72]
C-myc promoter-binding protein (DENND4A)	OT8FFZ29	MYCPP_HUMAN	Decreases Expression	[72]
COMM domain-containing protein 6 (COMMD6)	OTRZQJFW	COMD6_HUMAN	Increases Expression	[72]
Bone morphogenetic protein 8A (BMP8A)	OT1997IN	BMP8A_HUMAN	Increases Expression	[72]
Pleckstrin homology domain-containing family H member 3 (PLEKHH3)	OTREOQBO	PKHH3_HUMAN	Increases Expression	[72]
DNA damage-binding protein 2 (DDB2)	OTO8HVVB	DDB2_HUMAN	Increases Expression	[72]
Dual specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2)	OTMDVWPS	DYRK2_HUMAN	Decreases Expression	[72]
Histone H2A type 1-C (H2AC6)	OTF3YK7V	H2A1C_HUMAN	Decreases Expression	[72]
Aurora kinase B (AURKB)	OTIY4VHU	AURKB_HUMAN	Decreases Expression	[72]
Sorting nexin-18 (SNX18)	OT68KT3X	SNX18_HUMAN	Decreases Expression	[72]
Oncostatin-M-specific receptor subunit beta (OSMR)	OTORWHPL	OSMR_HUMAN	Increases Expression	[72]
Mitogen-activated protein kinase kinase kinase 5 (MAP3K5)	OTQR6ENW	M3K5_HUMAN	Decreases Expression	[72]
Growth/differentiation factor 15 (GDF15)	OTWQN50N	GDF15_HUMAN	Increases Expression	[72]
Ubiquitin-like-conjugating enzyme ATG10 (ATG10)	OTVRPC5X	ATG10_HUMAN	Decreases Expression	[72]
Serine/threonine-protein kinase PLK3 (PLK3)	OT19CT2Z	PLK3_HUMAN	Increases Expression	[72]
E3 ubiquitin-protein ligase Topors (TOPORS)	OT1ERFFQ	TOPRS_HUMAN	Decreases Expression	[72]
Serine/threonine-protein kinase PLK2 (PLK2)	OTKMJXJ8	PLK2_HUMAN	Increases Expression	[72]
Gamma-adducin (ADD3)	OTDRSHAZ	ADDG_HUMAN	Decreases Expression	[72]
Targeting protein for Xklp2 (TPX2)	OTWLJYH0	TPX2_HUMAN	Decreases Expression	[72]
Protocadherin gamma-C3 (PCDHGC3)	OTDXTUMI	PCDGK_HUMAN	Increases Expression	[72]
Tyrosine-protein phosphatase non-receptor type 22 (PTPN22)	OTDCNTC3	PTN22_HUMAN	Increases Expression	[72]
Structural maintenance of chromosomes flexible hinge domain-containing protein 1 (SMCHD1)	OTBV52DR	SMHD1_HUMAN	Decreases Expression	[73]
Serine/threonine-protein kinase Sgk1 (SGK1)	OT301T1U	SGK1_HUMAN	Increases Expression	[73]
Matrilin-2 (MATN2)	OTVDR68G	MATN2_HUMAN	Increases Expression	[73]
Krev interaction trapped protein 1 (KRIT1)	OT58AP1I	KRIT1_HUMAN	Decreases Expression	[73]
Proepiregulin (EREG)	OTRM4NQY	EREG_HUMAN	Decreases Expression	[73]
Calmegin (CLGN)	OTEWVFQV	CLGN_HUMAN	Increases Expression	[73]
Heterogeneous nuclear ribonucleoprotein D-like (HNRNPDL)	OTB3BFCV	HNRDL_HUMAN	Decreases Expression	[73]
Centrosomal protein of 290 kDa (CEP290)	OTVN52VH	CE290_HUMAN	Decreases Expression	[73]
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (ANKRD28)	OTRBREQ9	ANR28_HUMAN	Decreases Expression	[73]
FYN-binding protein 1 (FYB1)	OT6345CH	FYB1_HUMAN	Decreases Expression	[73]
Protein phosphatase 1D (PPM1D)	OT8NLZ9D	PPM1D_HUMAN	Increases Expression	[73]
Insulin-induced gene 1 protein (INSIG1)	OTZF5X1D	INSI1_HUMAN	Decreases Expression	[73]
Krueppel-like factor 4 (KLF4)	OT4O9RQW	KLF4_HUMAN	Increases Expression	[73]
Density-regulated protein (DENR)	OTXP9HOY	DENR_HUMAN	Decreases Expression	[73]
E3 ubiquitin-protein ligase MARCHF6 (MARCHF6)	OTBTA03N	MARH6_HUMAN	Increases Expression	[73]
Oligophrenin-1 (OPHN1)	OTDURZAV	OPHN1_HUMAN	Increases Expression	[73]
NEDD4-binding protein 1 (N4BP1)	OTN2TL6N	N4BP1_HUMAN	Decreases Expression	[73]
Ankyrin repeat domain-containing protein 17 (ANKRD17)	OTQ3DYEP	ANR17_HUMAN	Decreases Expression	[73]
Nuclear receptor corepressor 1 (NCOR1)	OT04XNOU	NCOR1_HUMAN	Decreases Expression	[73]
Death effector domain-containing protein (DEDD)	OTIL349E	DEDD_HUMAN	Decreases Expression	[73]
Glutaredoxin-3 (GLRX3)	OTUPAU1N	GLRX3_HUMAN	Affects Expression	[73]
Tubulin polymerization-promoting protein (TPPP)	OTCFMSUF	TPPP_HUMAN	Increases Expression	[73]
Protein transport protein Sec31A (SEC31A)	OT2U42AC	SC31A_HUMAN	Decreases Expression	[73]
SR-related and CTD-associated factor 4 (SCAF4)	OTFGHB1E	SCAF4_HUMAN	Decreases Expression	[73]
Reversion-inducing cysteine-rich protein with Kazal motifs (RECK)	OT9QIHEQ	RECK_HUMAN	Increases Expression	[73]
Tissue-type plasminogen activator (PLAT)	OTQPDNAB	TPA_HUMAN	Decreases Expression	[73]
Angiotensinogen (AGT)	OTBZLYR3	ANGT_HUMAN	Decreases Expression	[73]
HLA class I histocompatibility antigen, B alpha chain (HLA-B)	OTNXFWY2	HLAB_HUMAN	Decreases Expression	[73]
HLA class II histocompatibility antigen, DRB1 beta chain (HLA-DRB1)	OTRGGIFP	DRB1_HUMAN	Increases Expression	[73]
Myelin basic protein (MBP)	OTFZCEDB	MBP_HUMAN	Decreases Expression	[73]
Fibronectin (FN1)	OTB5ZN4Q	FINC_HUMAN	Increases Expression	[73]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Decreases Expression	[73]
Transferrin receptor protein 1 (TFRC)	OT8ZPBDL	TFR1_HUMAN	Increases Expression	[73]
Alpha-enolase (ENO1)	OTB1KWJS	ENOA_HUMAN	Decreases Expression	[73]
Transcription factor Sp1 (SP1)	OTISPT4X	SP1_HUMAN	Decreases Expression	[73]
Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1)	OTIRPN6B	ROA1_HUMAN	Decreases Expression	[73]
U2 small nuclear ribonucleoprotein A' (SNRPA1)	OTWJZFAP	RU2A_HUMAN	Decreases Expression	[73]
Interferon alpha-inducible protein 6 (IFI6)	OTWOOAM4	IFI6_HUMAN	Increases Expression	[73]
Chorionic somatomammotropin hormone 2 (CSH2)	OTW8JVAN	CSH2_HUMAN	Decreases Expression	[73]
Tissue factor pathway inhibitor (TFPI)	OTA0FX16	TFPI1_HUMAN	Decreases Expression	[73]
Breakpoint cluster region protein (BCR)	OTCN76C1	BCR_HUMAN	Decreases Expression	[73]
Interferon-induced transmembrane protein 1 (IFITM1)	OTECO1G8	IFM1_HUMAN	Increases Expression	[73]
HLA class II histocompatibility antigen, DR beta 4 chain (HLA-DRB4)	OTNXIHQU	DRB4_HUMAN	Increases Expression	[73]
NAD(P)H dehydrogenase 1 (NQO1)	OTZGGIVK	NQO1_HUMAN	Decreases Expression	[73]
Arylsulfatase B (ARSB)	OTTYDDNU	ARSB_HUMAN	Decreases Expression	[73]
Carboxypeptidase E (CPE)	OTXNTV79	CBPE_HUMAN	Increases Expression	[73]
Integrin alpha-2 (ITGA2)	OTPFL017	ITA2_HUMAN	Increases Expression	[73]
Gap junction alpha-1 protein (GJA1)	OTT94MKL	CXA1_HUMAN	Affects Expression	[73]
Peptidyl-glycine alpha-amidating monooxygenase (PAM)	OTX8HV5B	AMD_HUMAN	Decreases Expression	[73]
Glutathione hydrolase 1 proenzyme (GGT1)	OTYDA1Z7	GGT1_HUMAN	Decreases Expression	[73]
Ras GTPase-activating protein 1 (RASA1)	OTZJ3LP4	RASA1_HUMAN	Decreases Expression	[73]
Synaptotagmin-1 (SYT1)	OTVTPOI6	SYT1_HUMAN	Decreases Expression	[73]
Receptor-type tyrosine-protein phosphatase gamma (PTPRG)	OT9N2WOF	PTPRG_HUMAN	Decreases Expression	[73]
Paired box protein Pax-7 (PAX7)	OTDMQRPO	PAX7_HUMAN	Decreases Expression	[73]
Annexin A13 (ANXA13)	OTM33P73	ANX13_HUMAN	Decreases Expression	[73]
Lens fiber major intrinsic protein (MIP)	OTEBLU3E	MIP_HUMAN	Decreases Expression	[73]
Fibroblast growth factor 9 (FGF9)	OT2SKDGM	FGF9_HUMAN	Decreases Expression	[73]
Glycerol kinase (GK)	OTK2YRA0	GLPK_HUMAN	Decreases Expression	[73]
Cystathionine gamma-lyase (CTH)	OTC90LA0	CGL_HUMAN	Increases Expression	[73]
Myosin-10 (MYH10)	OTXN2WXS	MYH10_HUMAN	Decreases Expression	[73]
Large ribosomal subunit protein uL4 (RPL4)	OTTYJB0X	RL4_HUMAN	Decreases Expression	[73]
T-complex protein 1 subunit zeta (CCT6A)	OTCYWL5F	TCPZ_HUMAN	Decreases Expression	[73]
Reduced folate transporter (SLC19A1)	OTWB0BTO	S19A1_HUMAN	Decreases Expression	[73]
Matrin-3 (MATR3)	OTESJ5S7	MATR3_HUMAN	Decreases Expression	[73]
Transcriptional regulator ATRX (ATRX)	OT77RSQW	ATRX_HUMAN	Decreases Expression	[73]
Vesicle-fusing ATPase (NSF)	OTKRJ2ZT	NSF_HUMAN	Decreases Expression	[73]
Stromal cell-derived factor 1 (CXCL12)	OT2QX5LL	SDF1_HUMAN	Decreases Expression	[73]
Nuclear pore complex protein Nup153 (NUP153)	OTCAS0AR	NU153_HUMAN	Decreases Expression	[73]
Gastrotropin (FABP6)	OTIRQWLW	FABP6_HUMAN	Increases Expression	[73]
Host cell factor 1 (HCFC1)	OT0UCK62	HCFC1_HUMAN	Decreases Expression	[73]
Collagen alpha-4(IV) chain (COL4A4)	OT9G0MCT	CO4A4_HUMAN	Decreases Expression	[73]
Coatomer subunit alpha (COPA)	OTZ1DTXU	COPA_HUMAN	Increases Expression	[73]
Cadherin-4 (CDH4)	OT8LH3HN	CADH4_HUMAN	Decreases Expression	[73]
C-terminal-binding protein 2 (CTBP2)	OTGZGT87	CTBP2_HUMAN	Decreases Expression	[73]
ADP-ribosylation factor-like protein 4C (ARL4C)	OTQ3QNNU	ARL4C_HUMAN	Increases Expression	[73]
Epiplakin (EPPK1)	OT7BAU8C	EPIPL_HUMAN	Increases Expression	[73]
Lysyl oxidase homolog 3 (LOXL3)	OTLLY1QI	LOXL3_HUMAN	Decreases Expression	[73]
Histone H4 (H4C1)	OTB71W46	H4_HUMAN	Decreases Expression	[73]
AP-2 complex subunit beta (AP2B1)	OTL6LZJ4	AP2B1_HUMAN	Decreases Expression	[73]
Hemoglobin subunit gamma-1 (HBG1)	OTVL4NSU	HBG1_HUMAN	Decreases Expression	[73]
Mothers against decapentaplegic homolog 3 (SMAD3)	OTNA96MR	SMAD3_HUMAN	Decreases Expression	[73]
ADP-ribosylation factor 1 (ARF1)	OT5C4C3L	ARF1_HUMAN	Decreases Expression	[73]
Cyclin-dependent kinase 6 (CDK6)	OTR95N0X	CDK6_HUMAN	Affects Expression	[73]
Clathrin heavy chain 1 (CLTC)	OTBFASMA	CLH1_HUMAN	Decreases Expression	[73]
Centromere-associated protein E (CENPE)	OTQ7AP04	CENPE_HUMAN	Decreases Expression	[73]
Paired box protein Pax-5 (PAX5)	OTYBJJWX	PAX5_HUMAN	Decreases Expression	[73]
Dystonin (DST)	OTHZBM4X	DYST_HUMAN	Decreases Expression	[73]
Focal adhesion kinase 1 (PTK2)	OT3Q1JDY	FAK1_HUMAN	Decreases Expression	[73]
Recombining binding protein suppressor of hairless (RBPJ)	OTD7CUG0	SUH_HUMAN	Decreases Expression	[73]
KH domain-containing, RNA-binding, signal transduction-associated protein 1 (KHDRBS1)	OT5GO2PL	KHDR1_HUMAN	Decreases Expression	[73]
Protein phosphatase 3 catalytic subunit alpha (PPP3CA)	OT58PUEN	PP2BA_HUMAN	Decreases Expression	[73]
Leukocyte surface antigen CD47 (CD47)	OTLDZ0KZ	CD47_HUMAN	Increases Expression	[73]
Transmembrane protein 267 (TMEM267)	OTEAAVK7	TM267_HUMAN	Decreases Expression	[73]
Proline-rich nuclear receptor coactivator 1 (PNRC1)	OTQMLEE1	PNRC1_HUMAN	Increases Expression	[73]
Alpha-globin transcription factor CP2 (TFCP2)	OTA246TE	TFCP2_HUMAN	Decreases Expression	[73]
Disks large homolog 1 (DLG1)	OTCRZYWT	DLG1_HUMAN	Decreases Expression	[73]
Serine/threonine-protein kinase 4 (STK4)	OTBRYNNH	STK4_HUMAN	Decreases Expression	[73]
Acetyl-CoA carboxylase 1 (ACACA)	OT5CQPZY	ACACA_HUMAN	Decreases Expression	[73]
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)	OT7TNF0L	AAPK1_HUMAN	Decreases Expression	[73]
BMP and activin membrane-bound inhibitor homolog (BAMBI)	OTCEJ8W5	BAMBI_HUMAN	Increases Expression	[73]
Dynactin subunit 2 (DCTN2)	OTMB4IXD	DCTN2_HUMAN	Increases Expression	[73]
Cullin-4A (CUL4A)	OTTBV70J	CUL4A_HUMAN	Decreases Expression	[73]
Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD)	OT5UO1FA	HNRPD_HUMAN	Decreases Expression	[73]
Guanine nucleotide-binding protein subunit alpha-13 (GNA13)	OTVDL515	GNA13_HUMAN	Increases Expression	[73]
Disco-interacting protein 2 homolog A (DIP2A)	OTXPTR8R	DIP2A_HUMAN	Decreases Expression	[73]
Uncharacterized protein KIAA0040 (KIAA0040)	OT27EBY3	K0040_HUMAN	Increases Expression	[73]
Kinesin-like protein KIF14 (KIF14)	OTXHT4JM	KIF14_HUMAN	Decreases Expression	[73]
Transforming growth factor-beta-induced protein ig-h3 (TGFBI)	OTR443C5	BGH3_HUMAN	Decreases Expression	[73]
Cyclin-G2 (CCNG2)	OTII38K2	CCNG2_HUMAN	Increases Expression	[73]
MICOS complex subunit MIC60 (IMMT)	OTBDSLE7	MIC60_HUMAN	Affects Expression	[73]
WD40 repeat-containing protein SMU1 (SMU1)	OTLCSLGL	SMU1_HUMAN	Decreases Expression	[73]
Neuroblastoma breakpoint family member 1 (NBPF1)	OTAZ55UQ	NBPF1_HUMAN	Decreases Expression	[73]
Cell adhesion molecule-related/down-regulated by oncogenes (CDON)	OT81X593	CDON_HUMAN	Decreases Expression	[73]
Protein LBH (LBH)	OT87AT1X	LBH_HUMAN	Decreases Expression	[73]
Shugoshin 2 (SGO2)	OTNGJDS8	SGO2_HUMAN	Decreases Expression	[73]
PAN2-PAN3 deadenylation complex subunit PAN3 (PAN3)	OTYBA69S	PAN3_HUMAN	Decreases Expression	[73]
Sterile alpha motif domain-containing protein 9 (SAMD9)	OTDG48P0	SAMD9_HUMAN	Increases Expression	[73]
Serine/threonine-protein phosphatase 4 regulatory subunit 3B (PPP4R3B)	OT1VTUL9	P4R3B_HUMAN	Decreases Expression	[73]
Acyl-coenzyme A thioesterase THEM4 (THEM4)	OTSIZU8Y	THEM4_HUMAN	Decreases Expression	[73]
MAGUK p55 subfamily member 7 (MPP7)	OT3G3HTZ	MPP7_HUMAN	Increases Expression	[73]
DDB1- and CUL4-associated factor 8 (DCAF8)	OT3VFSLG	DCAF8_HUMAN	Decreases Expression	[73]
Collagen alpha-1(XIII) chain (COL13A1)	OTM9IM6J	CODA1_HUMAN	Increases Expression	[73]
Probable E3 ubiquitin-protein ligase HECTD2 (HECTD2)	OTDIBGQV	HECD2_HUMAN	Decreases Expression	[73]
Serine/threonine-protein kinase MRCK alpha (CDC42BPA)	OTCPFOSA	MRCKA_HUMAN	Decreases Expression	[73]
Rho GTPase-activating protein SYDE2 (SYDE2)	OTOEIXSM	SYDE2_HUMAN	Increases Expression	[73]
Deubiquitinase MYSM1 (MYSM1)	OTO73N00	MYSM1_HUMAN	Decreases Expression	[73]
AT-rich interactive domain-containing protein 2 (ARID2)	OTIRJXWM	ARID2_HUMAN	Decreases Expression	[73]
Glucose 1,6-bisphosphate synthase (PGM2L1)	OTSBNRT5	PGM2L_HUMAN	Increases Expression	[73]
UPF0547 protein C16orf87 (C16ORF87)	OT658H5A	CP087_HUMAN	Decreases Expression	[73]
Kelch-like protein 24 (KLHL24)	OTWZSX5C	KLH24_HUMAN	Increases Expression	[73]
Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L)	OTV01EFP	C1TM_HUMAN	Decreases Expression	[73]
Rho-related GTP-binding protein RhoU (RHOU)	OTERIAD4	RHOU_HUMAN	Increases Expression	[73]
Protein ABHD13 (ABHD13)	OTF2E8M6	ABHDD_HUMAN	Decreases Expression	[73]
G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)	OT06BFRQ	G2E3_HUMAN	Decreases Expression	[73]
Diphthine--ammonia ligase (DPH6)	OTOJ7BXR	DPH6_HUMAN	Decreases Expression	[73]
Pogo transposable element with ZNF domain (POGZ)	OT4CYWC1	POGZ_HUMAN	Decreases Expression	[73]
FERM domain-containing protein 5 (FRMD5)	OTC73XJK	FRMD5_HUMAN	Decreases Expression	[73]
Phosphatidylinositol-glycan biosynthesis class W protein (PIGW)	OTT9SMTF	PIGW_HUMAN	Decreases Expression	[73]
Amphoterin-induced protein 2 (AMIGO2)	OTPAIT1O	AMGO2_HUMAN	Increases Expression	[73]
Dihydrofolate reductase 2, mitochondrial (DHFR2)	OTPHUWEY	DYR2_HUMAN	Decreases Expression	[73]
ELKS/Rab6-interacting/CAST family member 1 (ERC1)	OTYBGGNO	RB6I2_HUMAN	Decreases Expression	[73]
Armadillo repeat-containing protein 8 (ARMC8)	OTNAXGM7	ARMC8_HUMAN	Decreases Expression	[73]
Mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3)	OTNJX38T	M4K3_HUMAN	Decreases Expression	[73]
Protein FAM219A (FAM219A)	OTAFZHY9	F219A_HUMAN	Decreases Expression	[73]
Homeobox protein Mohawk (MKX)	OT7H7Z50	MKX_HUMAN	Decreases Expression	[73]
Threonine synthase-like 1 (THNSL1)	OTQNFH3E	THNS1_HUMAN	Decreases Expression	[73]
Porimin (TMEM123)	OTDMVZD6	PORIM_HUMAN	Decreases Expression	[73]
Rho guanine nucleotide exchange factor 39 (ARHGEF39)	OT9UKTQ5	ARG39_HUMAN	Decreases Expression	[73]
Type 2 DNA topoisomerase 6 subunit B-like (TOP6BL)	OTCYPUNK	TO6BL_HUMAN	Increases Expression	[73]
Protein SCAI (SCAI)	OTAK3TMO	SCAI_HUMAN	Decreases Expression	[73]
Diacylglycerol lipase-beta (DAGLB)	OT1S9869	DGLB_HUMAN	Decreases Expression	[73]
Regulator of G-protein signaling 22 (RGS22)	OTCTFGW6	RGS22_HUMAN	Decreases Expression	[73]
Phospholipase DDHD1 (DDHD1)	OTWTHOWK	DDHD1_HUMAN	Decreases Expression	[73]
Lysophosphatidylcholine acyltransferase 1 (LPCAT1)	OTCV7AGV	PCAT1_HUMAN	Decreases Expression	[73]
Biorientation of chromosomes in cell division protein 1-like 1 (BOD1L1)	OTTD5FJ8	BD1L1_HUMAN	Decreases Expression	[73]
Atlastin-2 (ATL2)	OT93AUOO	ATLA2_HUMAN	Increases Expression	[73]
Centrosomal protein of 192 kDa (CEP192)	OTBLFV7T	CE192_HUMAN	Decreases Expression	[73]
DEP domain-containing protein 1B (DEPDC1B)	OTMVFOT1	DEP1B_HUMAN	Decreases Expression	[73]
Pleckstrin homology-like domain family A member 1 (PHLDA1)	OTFTWMIQ	PHLA1_HUMAN	Decreases Expression	[73]
Microprocessor complex subunit DGCR8 (DGCR8)	OT62LXE4	DGCR8_HUMAN	Decreases Expression	[73]
Tribbles homolog 2 (TRIB2)	OTHSX3MX	TRIB2_HUMAN	Affects Expression	[73]
Protein FAM3C (FAM3C)	OTBR6U9G	FAM3C_HUMAN	Decreases Expression	[73]
CREB-binding protein (CREBBP)	OTPA4QGM	CBP_HUMAN	Decreases Expression	[73]
Histone acetyltransferase KAT2B (KAT2B)	OTWQITWK	KAT2B_HUMAN	Increases Expression	[73]
Homeobox protein DLX-4 (DLX4)	OTLWVCN4	DLX4_HUMAN	Increases Expression	[73]
Protein tyrosine phosphatase type IVA 1 (PTP4A1)	OTK0NFXJ	TP4A1_HUMAN	Decreases Expression	[73]
Tumor protein p53-inducible nuclear protein 1 (TP53INP1)	OT2363Z9	T53I1_HUMAN	Increases Expression	[73]
Exocyst complex component 4 (EXOC4)	OT5EWXAN	EXOC4_HUMAN	Decreases Expression	[73]
RalBP1-associated Eps domain-containing protein 1 (REPS1)	OTX4ERRK	REPS1_HUMAN	Decreases Expression	[73]
Protein LTV1 homolog (LTV1)	OTZILJDI	LTV1_HUMAN	Decreases Expression	[73]
PDZ and LIM domain protein 5 (PDLIM5)	OTLQVV22	PDLI5_HUMAN	Decreases Expression	[73]
DISP complex protein LRCH3 (LRCH3)	OTDLBLMU	LRCH3_HUMAN	Decreases Expression	[73]
Rho GTPase-activating protein 7 (DLC1)	OTP8LMCR	RHG07_HUMAN	Decreases Expression	[73]
Tribbles homolog 1 (TRIB1)	OTPEO17G	TRIB1_HUMAN	Increases Expression	[73]
Mitochondrial inner membrane protease subunit 2 (IMMP2L)	OT9WGAFD	IMP2L_HUMAN	Decreases Expression	[73]
Transcription factor 12 (TCF12)	OTZVONNU	HTF4_HUMAN	Decreases Expression	[73]
ATP synthase subunit s, mitochondrial (DMAC2L)	OT2OQ1UD	ATP5S_HUMAN	Decreases Expression	[73]
Semaphorin-3C (SEMA3C)	OTEGUY7F	SEM3C_HUMAN	Increases Expression	[73]
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 (DPH2)	OT9P91XR	DPH2_HUMAN	Decreases Expression	[73]
Mitochondrial 2-oxodicarboxylate carrier (SLC25A21)	OTB78IF4	ODC_HUMAN	Decreases Expression	[73]
Deubiquitinase DESI2 (DESI2)	OTHUOKOC	DESI2_HUMAN	Decreases Expression	[73]
Acireductone dioxygenase (ADI1)	OT8IOD03	MTND_HUMAN	Decreases Expression	[73]
Protein C1orf43 (C1ORF43)	OTT9CVZR	CA043_HUMAN	Decreases Expression	[73]
RNA-binding protein 24 (RBM24)	OTQI1AR1	RBM24_HUMAN	Increases Expression	[73]
Nucleolar and spindle-associated protein 1 (NUSAP1)	OT85HIJ5	NUSAP_HUMAN	Decreases Expression	[73]
E3 ubiquitin-protein ligase TRIM9 (TRIM9)	OTKYG33W	TRIM9_HUMAN	Increases Expression	[73]
E3 ubiquitin-protein ligase TRIM4 (TRIM4)	OTLKQNKQ	TRIM4_HUMAN	Increases Expression	[73]
Histone-lysine N-methyltransferase SETD5 (SETD5)	OTRPAVEO	SETD5_HUMAN	Decreases Expression	[73]
Alpha-ketoglutarate-dependent dioxygenase FTO (FTO)	OTXML85Y	FTO_HUMAN	Decreases Expression	[73]
Centrosomal protein of 295 kDa (CEP295)	OTVTTXRO	CE295_HUMAN	Decreases Expression	[73]
Sentrin-specific protease 6 (SENP6)	OT05LLF4	SENP6_HUMAN	Decreases Expression	[73]
Cytochrome c oxidase assembly factor 1 homolog (COA1)	OTHSX40F	COA1_HUMAN	Decreases Expression	[73]
Disintegrin and metalloproteinase domain-containing protein 19 (ADAM19)	OTH88TXU	ADA19_HUMAN	Increases Expression	[73]
Pterin-4-alpha-carbinolamine dehydratase 2 (PCBD2)	OTXV0ZD0	PHS2_HUMAN	Decreases Expression	[73]
Metal transporter CNNM2 (CNNM2)	OTZHO8WU	CNNM2_HUMAN	Increases Expression	[73]
Pleckstrin homology domain-containing family A member 5 (PLEKHA5)	OT2MNW8T	PKHA5_HUMAN	Decreases Expression	[73]
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCC2)	OTQDHSMI	MCCB_HUMAN	Decreases Expression	[73]
E3 ubiquitin-protein ligase SMURF1 (SMURF1)	OT5UIZR8	SMUF1_HUMAN	Affects Expression	[73]
Large ribosomal subunit protein mL65 (MRPS30)	OTDXIAGG	RT30_HUMAN	Decreases Expression	[73]
Transcription factor 7-like 2 (TCF7L2)	OTVWPZ8B	TF7L2_HUMAN	Decreases Expression	[73]
Muscleblind-like protein 1 (MBNL1)	OTOV7J85	MBNL1_HUMAN	Decreases Expression	[73]
Lymphoid-specific helicase (HELLS)	OTVVV668	HELLS_HUMAN	Decreases Expression	[73]
Phenylalanine--tRNA ligase beta subunit (FARSB)	OT8N9TT5	SYFB_HUMAN	Decreases Expression	[73]
Midasin (MDN1)	OTNBSPTW	MDN1_HUMAN	Affects Expression	[73]
tRNA:m(4)X modification enzyme TRM13 homolog (TRMT13)	OT2H0MCE	TRM13_HUMAN	Decreases Expression	[73]
E3 ubiquitin-protein ligase RLIM (RLIM)	OTEBRNHJ	RNF12_HUMAN	Decreases Expression	[73]
G patch domain-containing protein 2-like (GPATCH2L)	OTETUZ64	GPT2L_HUMAN	Decreases Expression	[73]
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (PAG1)	OTFOJUIQ	PHAG1_HUMAN	Increases Expression	[73]
Huntingtin-interacting protein K (HYPK)	OTRWRVWN	HYPK_HUMAN	Affects Expression	[73]
Inhibitor of growth protein 3 (ING3)	OTDIJXFP	ING3_HUMAN	Decreases Expression	[73]
Rho guanine nucleotide exchange factor 12 (ARHGEF12)	OTM2D3LT	ARHGC_HUMAN	Decreases Expression	[73]
Cysteine-rich motor neuron 1 protein (CRIM1)	OTTZNV6Y	CRIM1_HUMAN	Decreases Expression	[73]
Voltage-dependent T-type calcium channel subunit alpha-1I (CACNA1I)	OTRH8X8A	CAC1I_HUMAN	Decreases Expression	[73]
eIF-2-alpha kinase GCN2 (EIF2AK4)	OTLE1JY8	E2AK4_HUMAN	Affects Expression	[73]
DNA polymerase kappa (POLK)	OTKZ38JH	POLK_HUMAN	Decreases Expression	[73]
Mediator of RNA polymerase II transcription subunit 13 (MED13)	OTP5LEJE	MED13_HUMAN	Decreases Expression	[73]
Jupiter microtubule associated homolog 1 (JPT1)	OT6CRZEU	JUPI1_HUMAN	Decreases Expression	[73]
BTB/POZ domain-containing protein 3 (BTBD3)	OTZ607YT	BTBD3_HUMAN	Decreases Expression	[73]
Thyroid hormone receptor-associated protein 3 (THRAP3)	OTG25JOG	TR150_HUMAN	Decreases Expression	[73]
rRNA-processing protein FCF1 homolog (FCF1)	OTTI9M2D	FCF1_HUMAN	Affects Expression	[73]
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (SAMHD1)	OTBCIBC7	SAMH1_HUMAN	Affects Expression	[73]
Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 (HS3ST3B1)	OTK53GUD	HS3SB_HUMAN	Increases Expression	[73]
Calcineurin-binding protein cabin-1 (CABIN1)	OT4G5CIK	CABIN_HUMAN	Decreases Expression	[73]
Proton-coupled zinc antiporter SLC30A1 (SLC30A1)	OTY8J0S4	ZNT1_HUMAN	Decreases Expression	[73]
Serine/threonine-protein kinase Chk1 (CHEK1)	OTTTI622	CHK1_HUMAN	Increases Phosphorylation	[95]
CASP8 and FADD-like apoptosis regulator (CFLAR)	OTX14BAS	CFLAR_HUMAN	Decreases Expression	[96]
Ubiquinone biosynthesis protein COQ9, mitochondrial (COQ9)	OTM2T1FI	COQ9_HUMAN	Decreases Expression	[75]
Interleukin-33 (IL33)	OTT5YWK3	IL33_HUMAN	Increases Expression	[97]
Serine/threonine-protein kinase Chk2 (CHEK2)	OT8ZPCNS	CHK2_HUMAN	Increases Phosphorylation	[98]
Superoxide dismutase (SOD1)	OT39TA1L	SODC_HUMAN	Increases Expression	[97]
Urokinase-type plasminogen activator (PLAU)	OTX0QGKK	UROK_HUMAN	Decreases Secretion	[99]
Protransforming growth factor alpha (TGFA)	OTPD1LL9	TGFA_HUMAN	Increases Secretion	[100]
Tumor necrosis factor (TNF)	OT4IE164	TNFA_HUMAN	Increases Expression	[101]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Increases Expression	[98]
Protein kinase C beta type (PRKCB)	OTYQ0656	KPCB_HUMAN	Increases Phosphorylation	[100]
Retinoblastoma-associated protein (RB1)	OTQJUJMZ	RB_HUMAN	Affects Expression	[102]
DNA excision repair protein ERCC-1 (ERCC1)	OTNPYQHI	ERCC1_HUMAN	Decreases Expression	[74]
Heme oxygenase 1 (HMOX1)	OTC1W6UX	HMOX1_HUMAN	Increases Expression	[97]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Increases Expression	[103]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Increases Expression	[100]
Amphiregulin (AREG)	OTJFOR67	AREG_HUMAN	Increases Expression	[100]
Methylated-DNA--protein-cysteine methyltransferase (MGMT)	OT40A9WH	MGMT_HUMAN	Decreases Expression	[104]
Protein kinase C alpha type (PRKCA)	OT5UWNRD	KPCA_HUMAN	Increases Phosphorylation	[100]
Nuclear factor NF-kappa-B p105 subunit (NFKB1)	OTNRRD8I	NFKB1_HUMAN	Increases Activity	[101]
3-mercaptopyruvate sulfurtransferase (MPST)	OTCDPH5D	THTM_HUMAN	Decreases Expression	[75]
Tumor necrosis factor receptor superfamily member 6 (FAS)	OTP9XG86	TNR6_HUMAN	Increases Expression	[105]
CCN family member 2 (CCN2)	OTC39NSU	CCN2_HUMAN	Increases Expression	[75]
Nitric oxide synthase, inducible (NOS2)	OTKKIOJ1	NOS2_HUMAN	Increases Expression	[97]
Peroxisome proliferator-activated receptor gamma (PPARG)	OTHMARHO	PPARG_HUMAN	Decreases Expression	[97]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Increases Expression	[106]
Protein kinase C iota type (PRKCI)	OTKBAVT3	KPCI_HUMAN	Increases Phosphorylation	[100]
Signal transducer and activator of transcription 1-alpha/beta (STAT1)	OTLMBUZ6	STAT1_HUMAN	Increases Phosphorylation	[105]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Increases Activity	[107]
Cyclin-dependent kinase inhibitor 2A (CDKN2A)	OTN0ZWAE	CDN2A_HUMAN	Decreases Expression	[108]
Radiation-inducible immediate-early gene IEX-1 (IER3)	OTZJI5FZ	IEX1_HUMAN	Increases Expression	[75]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10)	OT4PXBTA	TNF10_HUMAN	Increases Activity	[96]
Caspase-9 (CASP9)	OTD4RFFG	CASP9_HUMAN	Increases Activity	[98]
BH3-interacting domain death agonist (BID)	OTOSHSHU	BID_HUMAN	Decreases Expression	[109]
Rho-related GTP-binding protein RhoB (RHOB)	OTHQFQF7	RHOB_HUMAN	Increases Expression	[75]
DNA-dependent protein kinase catalytic subunit (PRKDC)	OTJVS4EG	PRKDC_HUMAN	Increases Phosphorylation	[110]
Transcription factor p65 (RELA)	OTUJP9CN	TF65_HUMAN	Increases Activity	[101]
Protein kinase C delta type (PRKCD)	OTSEH90E	KPCD_HUMAN	Increases Phosphorylation	[100]
DNA repair protein RAD51 homolog 1 (RAD51)	OTNVWGC1	RAD51_HUMAN	Increases Expression	[111]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Decreases Expression	[108]
Serine-protein kinase ATM (ATM)	OTQVOHLT	ATM_HUMAN	Increases Phosphorylation	[98]
Transcription factor HES-1 (HES1)	OT8P19W2	HES1_HUMAN	Increases Activity	[112]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Increases Activity	[108]
Nuclear factor erythroid 2-related factor 2 (NFE2L2)	OT0HENJ5	NF2L2_HUMAN	Increases Expression	[97]
Extracellular tyrosine-protein kinase PKDCC (PKDCC)	OTVXJR26	PKDCC_HUMAN	Decreases Expression	[75]
Pleckstrin homology-like domain family A member 2 (PHLDA2)	OTMV9DPP	PHLA2_HUMAN	Increases Expression	[75]
Docking protein 6 (DOK6)	OTX55OIF	DOK6_HUMAN	Decreases Expression	[75]
tRNA-splicing endonuclease subunit Sen2 (TSEN2)	OT1UWYRI	SEN2_HUMAN	Decreases Expression	[75]
Protein FAN (NSMAF)	OTYNVZ23	FAN_HUMAN	Decreases Expression	[75]
Probable ATP-dependent RNA helicase DDX17 (DDX17)	OTXRMMBP	DDX17_HUMAN	Decreases Expression	[75]
F-box/WD repeat-containing protein 5 (FBXW5)	OT5TQK3H	FBXW5_HUMAN	Increases Expression	[75]
PRKC apoptosis WT1 regulator protein (PAWR)	OTKY7W52	PAWR_HUMAN	Decreases Expression	[75]
Proheparin-binding EGF-like growth factor (HBEGF)	OTLU00JS	HBEGF_HUMAN	Increases Expression	[100]
Homeobox protein HMX1 (HMX1)	OT65ZGE0	HMX1_HUMAN	Increases Expression	[75]
Abl interactor 2 (ABI2)	OT8GIIS5	ABI2_HUMAN	Decreases Expression	[75]
Inhibitor of Bruton tyrosine kinase (IBTK)	OTB2GM4G	IBTK_HUMAN	Decreases Expression	[75]
SERTA domain-containing protein 1 (SERTAD1)	OTBHKZQP	SRTD1_HUMAN	Increases Expression	[75]
Thrombospondin-1 (THBS1)	OT0ECWK3	TSP1_HUMAN	Decreases Response To Substance	[113]
Phospholipid phosphatase 1 (PLPP1)	OT0IIMI5	PLPP1_HUMAN	Decreases Response To Substance	[113]
DNA polymerase alpha catalytic subunit (POLA1)	OT1WXFVY	DPOLA_HUMAN	Increases Response To Substance	[113]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	OT2YYI1A	MCL1_HUMAN	Decreases Response To Substance	[114]
Collagen alpha-1(VII) chain (COL7A1)	OT3MIRZJ	CO7A1_HUMAN	Decreases Response To Substance	[113]
Integrin alpha-E (ITGAE)	OT41KCRX	ITAE_HUMAN	Increases Response To Substance	[113]
Nicastrin (NCSTN)	OT5QBTA4	NICA_HUMAN	Affects Response To Substance	[112]
V-type proton ATPase 21 kDa proteolipid subunit c'' (ATP6V0B)	OT8GTI1V	VATO_HUMAN	Increases Response To Substance	[113]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Affects Response To Substance	[115]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1)	OT9HYT7A	PLCB1_HUMAN	Increases ADR	[116]
DNA polymerase epsilon subunit 2 (POLE2)	OTAC9V6L	DPOE2_HUMAN	Increases Response To Substance	[113]
Protein DBF4 homolog A (DBF4)	OTBL7JHQ	DBF4A_HUMAN	Increases Response To Substance	[113]
Glucocorticoid receptor (NR3C1)	OTCI2YDI	GCR_HUMAN	Decreases Response To Substance	[113]
Cell division cycle protein 20 homolog (CDC20)	OTCOEZRV	CDC20_HUMAN	Increases Response To Substance	[113]
RNA-binding motif, single-stranded-interacting protein 1 (RBMS1)	OTD13PJN	RBMS1_HUMAN	Decreases Response To Substance	[113]
S-phase kinase-associated protein 2 (SKP2)	OTD5B41X	SKP2_HUMAN	Increases Response To Substance	[113]
Pre-B-cell leukemia transcription factor-interacting protein 1 (PBXIP1)	OTEAAUBY	PBIP1_HUMAN	Decreases Response To Substance	[113]
NF-kappa-B inhibitor alpha (NFKBIA)	OTFT924M	IKBA_HUMAN	Increases Response To Substance	[117]
DNA mismatch repair protein Mlh1 (MLH1)	OTG5XDD8	MLH1_HUMAN	Affects Response To Substance	[115]
Origin recognition complex subunit 1 (ORC1)	OTHWU8IJ	ORC1_HUMAN	Increases Response To Substance	[113]
U6 snRNA-associated Sm-like protein LSm7 (LSM7)	OTHZ2XPX	LSM7_HUMAN	Increases Response To Substance	[113]
Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)	OTJC60Q7	THIL_HUMAN	Increases Response To Substance	[113]
Transcriptional activator Myb (MYB)	OTJH64IV	MYB_HUMAN	Increases Response To Substance	[113]
CCN family member 1 (CCN1)	OTKJBEMD	CCN1_HUMAN	Decreases Response To Substance	[113]
Ras-related protein Rab-31 (RAB31)	OTMLXQZ0	RAB31_HUMAN	Decreases Response To Substance	[113]
Copper-transporting ATPase 1 (ATP7A)	OTMR3GXP	ATP7A_HUMAN	Decreases Response To Substance	[118]
Plasma membrane calcium-transporting ATPase 4 (ATP2B4)	OTMWFDAC	AT2B4_HUMAN	Decreases Response To Substance	[113]
E3 ubiquitin-protein ligase CCNB1IP1 (CCNB1IP1)	OTOTVMC8	CIP1_HUMAN	Increases Response To Substance	[113]
Protein FAM50B (FAM50B)	OTP3H38A	FA50B_HUMAN	Increases ADR	[46]
DNA fragmentation factor subunit beta (DFFB)	OTPBW5N5	DFFB_HUMAN	Increases Response To Substance	[113]
ATP-binding cassette sub-family B member 6 (ABCB6)	OTPGZFES	ABCB6_HUMAN	Decreases Response To Substance	[119]
E3 ubiquitin-protein ligase RNF34 (RNF34)	OTQY58LU	RNF34_HUMAN	Decreases Response To Substance	[107]
DNA-directed RNA polymerase III subunit RPC7 (POLR3G)	OTU3TGQ9	RPC7_HUMAN	Increases Response To Substance	[113]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Decreases Response To Substance	[120]
NADPH--cytochrome P450 reductase (POR)	OTVIDOCH	NCPR_HUMAN	Increases Response To Substance	[90]
Protein NDRG1 (NDRG1)	OTVO66BO	NDRG1_HUMAN	Decreases Response To Substance	[121]
Phosphoserine aminotransferase (PSAT1)	OTVV1YV9	SERC_HUMAN	Increases Response To Substance	[113]
Uncharacterized protein C8orf34 (C8ORF34)	OTXCTHDG	CH034_HUMAN	Increases ADR	[116]
Small nuclear ribonucleoprotein F (SNRPF)	OTZE5W6G	RUXF_HUMAN	Increases Response To Substance	[113]
Adenylate kinase 2, mitochondrial (AK2)	OTZG3X2H	KAD2_HUMAN	Increases Response To Substance	[113]

Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
Neoplasms, Unknown Primary	DCYE274	N. A.	Phase 1	[122]

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