Details of the Drug Combination

General Information of Drug Combination (ID: DCUFLM8)

Drug Combination Name
Gemcitabine MK-2206
Indication
Disease Entry Status REF
Malignant melanoma Investigative [1]
Component Drugs Gemcitabine   DMSE3I7 MK-2206   DMT1OZ6
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: HT144
Zero Interaction Potency (ZIP) Score: 5.02
Bliss Independence Score: 9.74
Loewe Additivity Score: 11.81
LHighest Single Agent (HSA) Score: 13.28

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Gemcitabine
Disease Entry ICD 11 Status REF
Anterior urethra cancer N.A. Approved [2]
Biliary tract cancer 2C17 Approved [2]
Carcinoma 2A00-2F9Z Approved [2]
Cervical cancer 2C77.0 Approved [2]
Cholangiocarcinoma 2C12.10 Approved [2]
Fallopian tube neoplasm N.A. Approved [2]
Gallbladder carcinoma N.A. Approved [2]
Leiomyosarcoma 2B58 Approved [2]
Leukemia N.A. Approved [2]
Lung cancer 2C25.0 Approved [2]
MALT lymphoma N.A. Approved [2]
Nodal marginal zone lymphoma 2A85.0 Approved [2]
Non-small-cell lung cancer 2C25 Approved [3]
Ovarian disorder N.A. Approved [2]
Ovarian neoplasm N.A. Approved [2]
Pancreatic adenocarcinoma N.A. Approved [2]
Pancreatic ductal carcinoma 2C10.0 Approved [2]
Pancreatic tumour 2C10 Approved [2]
Posterior urethra cancer N.A. Approved [2]
Recurrent adult burkitt lymphoma 2A85.6 Approved [2]
Solid tumour/cancer 2A00-2F9Z Approved [4]
Splenic marginal zone lymphoma N.A. Approved [2]
Urethral cancer 2C93 Approved [2]
Urinary bladder neoplasm N.A. Approved [2]
Middle East Respiratory Syndrome (MERS) 1D64 Preclinical [5]
Severe acute respiratory syndrome (SARS) 1D65 Preclinical [5]
Colon cancer 2B90.Z Investigative [2]
Gemcitabine Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Ribonucleoside-diphosphate reductase M2 (RRM2) TTBWDI0 RIR2_HUMAN Modulator [14]
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Gemcitabine Interacts with 3 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [15]
Multidrug resistance-associated protein 5 (ABCC5) DTYVM24 MRP5_HUMAN Substrate [16]
Concentrative nucleoside transporter 1 (SLC28A1) DT0EQPW S28A1_HUMAN Substrate [17]
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Gemcitabine Interacts with 5 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytidine aminohydrolase (CDA) DEKEDRC CDD_HUMAN Metabolism [18]
Uridine/cytidine monophosphate kinase (UMPK) DEMPH4I KCY_HUMAN Metabolism [19]
Cytidine deaminase (cdd) DETX3A5 CDD_ECOLI Metabolism [20]
Cytidine deaminase (cdd) DEFVABT CDD_KLEP7 Metabolism [20]
Cytidine deaminase (cdd) DEYILK4 E0TLJ6_MYCHH Metabolism [21]
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Gemcitabine Interacts with 244 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytidine deaminase (CDA) OT3HXP6N CDD_HUMAN Affects Response To Substance [12]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Decreases Expression [22]
Ribonucleoside-diphosphate reductase subunit M2 (RRM2) OTOB6J6R RIR2_HUMAN Affects Response To Substance [13]
Ribonucleoside-diphosphate reductase large subunit (RRM1) OTXGQOR9 RIR1_HUMAN Affects Response To Substance [13]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Increases Expression [23]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Decreases Expression [24]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [25]
NF-kappa-B inhibitor epsilon (NFKBIE) OTLAYEL9 IKBE_HUMAN Affects Expression [8]
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) OTQ4W7MT TR11B_HUMAN Increases Expression [8]
Stearoyl-CoA desaturase (SCD) OTB1073G SCD_HUMAN Increases Expression [8]
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2) OT5I4Y9K PLCB_HUMAN Decreases Expression [8]
Insulin-induced gene 1 protein (INSIG1) OTZF5X1D INSI1_HUMAN Increases Expression [8]
E3 ubiquitin-protein ligase Praja-2 (PJA2) OT45TMC4 PJA2_HUMAN Increases Expression [8]
Interleukin-1 receptor-associated kinase-like 2 (IRAK2) OT6Y1QZN IRAK2_HUMAN Increases Expression [8]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Increases Expression [8]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L) OTJKOMXE BNI3L_HUMAN Increases Expression [8]
Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP) OTRNDZXB HNRPQ_HUMAN Decreases Expression [8]
Melanoma-associated antigen C1 (MAGEC1) OTHMFHH8 MAGC1_HUMAN Increases Expression [8]
Liprin-alpha-4 (PPFIA4) OTWXG0DO LIPA4_HUMAN Increases Expression [8]
Transcription factor Maf (MAF) OT1GR3IZ MAF_HUMAN Increases Expression [8]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) OTYG179K PR15A_HUMAN Increases Expression [8]
Krueppel-like factor 8 (KLF8) OTUC5CDB KLF8_HUMAN Increases Expression [8]
Urokinase-type plasminogen activator (PLAU) OTX0QGKK UROK_HUMAN Increases Expression [8]
Fibrinogen gamma chain (FGG) OT5BJSEX FIBG_HUMAN Affects Expression [8]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Increases Expression [8]
Keratin, type II cytoskeletal 8 (KRT8) OTTM4X11 K2C8_HUMAN Decreases Expression [8]
Growth-regulated alpha protein (CXCL1) OT3WCTZV GROA_HUMAN Increases Expression [8]
Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) OTXOQDSG IFIT1_HUMAN Increases Expression [8]
Transcriptional activator Myb (MYB) OTJH64IV MYB_HUMAN Increases Expression [8]
Osteopontin (SPP1) OTJGC23Y OSTP_HUMAN Increases Expression [8]
Endoplasmic reticulum chaperone BiP (HSPA5) OTFUIRAO BIP_HUMAN Increases Expression [8]
Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3) OT2HZK5M GTR3_HUMAN Increases Expression [8]
Creatine kinase B-type (CKB) OTUCKOTT KCRB_HUMAN Decreases Expression [8]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Increases Expression [8]
Homeobox protein Hox-B2 (HOXB2) OTTD6HMV HXB2_HUMAN Increases Expression [8]
Fos-related antigen 2 (FOSL2) OT3MT9HJ FOSL2_HUMAN Decreases Expression [8]
Methylated-DNA--protein-cysteine methyltransferase (MGMT) OT40A9WH MGMT_HUMAN Decreases Expression [8]
CCAAT/enhancer-binding protein beta (CEBPB) OTM9MQIA CEBPB_HUMAN Increases Expression [8]
Early growth response protein 1 (EGR1) OTCP6XGZ EGR1_HUMAN Increases Expression [8]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) OTC1UOHP ATF3_HUMAN Increases Expression [8]
C-X-C motif chemokine 2 (CXCL2) OTEJCYMY CXCL2_HUMAN Increases Expression [8]
C-X-C motif chemokine 3 (CXCL3) OTSL94KH CXCL3_HUMAN Increases Expression [8]
Endothelin-2 (EDN2) OTQ7RCPI EDN2_HUMAN Decreases Expression [8]
Tumor necrosis factor alpha-induced protein 3 (TNFAIP3) OTVLI4DD TNAP3_HUMAN Increases Expression [8]
Diamine acetyltransferase 1 (SAT1) OT52AU22 SAT1_HUMAN Increases Expression [8]
Prostaglandin G/H synthase 1 (PTGS1) OTHCRLEC PGH1_HUMAN Decreases Expression [8]
G1/S-specific cyclin-D1 (CCND1) OT8HPTKJ CCND1_HUMAN Decreases Expression [8]
Tumor necrosis factor receptor superfamily member 5 (CD40) OT5YU2XB TNR5_HUMAN Decreases Expression [8]
Myristoylated alanine-rich C-kinase substrate (MARCKS) OT7N056G MARCS_HUMAN Increases Expression [8]
Protein EVI2B (EVI2B) OT98X1OE EVI2B_HUMAN Decreases Expression [8]
Heat shock 70 kDa protein 1-like (HSPA1L) OTC2V1K6 HS71L_HUMAN Decreases Expression [8]
Glutaredoxin-1 (GLRX) OT0QHTAR GLRX1_HUMAN Increases Expression [8]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [8]
Nicotinamide N-methyltransferase (NNMT) OTFM38GU NNMT_HUMAN Increases Expression [8]
B-cell lymphoma 6 protein (BCL6) OTQAWWO1 BCL6_HUMAN Increases Expression [8]
Regulator of G-protein signaling 2 (RGS2) OT0FSRW7 RGS2_HUMAN Increases Expression [8]
Leukemia inhibitory factor receptor (LIFR) OT36W9O5 LIFR_HUMAN Increases Expression [8]
Melanoma-associated antigen 10 (MAGEA10) OTI4KPYB MAGAA_HUMAN Decreases Expression [8]
Lysophosphatidic acid receptor 6 (LPAR6) OT4BY3W4 LPAR6_HUMAN Decreases Expression [8]
Ras GTPase-activating-like protein IQGAP1 (IQGAP1) OTZRWTGA IQGA1_HUMAN Increases Expression [8]
Retinaldehyde dehydrogenase 3 (ALDH1A3) OT1C9NKQ AL1A3_HUMAN Increases Expression [8]
Max-interacting protein 1 (MXI1) OTUQ9E0D MXI1_HUMAN Increases Expression [8]
ETS translocation variant 1 (ETV1) OT6PMJIK ETV1_HUMAN Increases Expression [8]
Glypican-3 (GPC3) OTWS8WSW GPC3_HUMAN Increases Expression [8]
Transcription initiation factor IIA subunit 1 (GTF2A1) OTWW4PN0 TF2AA_HUMAN Affects Expression [8]
Growth arrest-specific protein 1 (GAS1) OTKJXG52 GAS1_HUMAN Decreases Expression [8]
Puromycin-sensitive aminopeptidase (NPEPPS) OTMENFXR PSA_HUMAN Decreases Expression [8]
Methionine--tRNA ligase, cytoplasmic (MARS1) OTLJ6MHJ SYMC_HUMAN Increases Expression [8]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN) OTOWDUNT PTEN_HUMAN Affects Expression [8]
Ras-related protein Rab-8A (RAB8A) OTPB54Y3 RAB8A_HUMAN Decreases Expression [8]
Lysozyme C (LYZ) OTD7H0G6 LYSC_HUMAN Decreases Expression [8]
Transforming growth factor beta-2 proprotein (TGFB2) OTC0TXEP TGFB2_HUMAN Increases Expression [8]
Large ribosomal subunit protein eL37 (RPL37) OTB6SDZ1 RL37_HUMAN Increases Expression [8]
Histone H4 (H4C1) OTB71W46 H4_HUMAN Decreases Expression [8]
C-C motif chemokine 20 (CCL20) OTUCJY4N CCL20_HUMAN Increases Expression [8]
ADP-ribosylation factor 1 (ARF1) OT5C4C3L ARF1_HUMAN Decreases Expression [8]
Nuclear factor NF-kappa-B p100 subunit (NFKB2) OTS231V7 NFKB2_HUMAN Affects Expression [8]
Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase , mitochondrial (ALDH6A1) OT8LCZCT MMSA_HUMAN Increases Expression [8]
Pro-neuregulin-1, membrane-bound isoform (NRG1) OTZO6F1X NRG1_HUMAN Increases Expression [8]
Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) OTFH9M73 PTN11_HUMAN Affects Expression [8]
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1) OTG2T749 CP24A_HUMAN Decreases Expression [8]
ATP-dependent RNA helicase A (DHX9) OT5AAOQI DHX9_HUMAN Decreases Expression [8]
Nuclear cap-binding protein subunit 1 (NCBP1) OTYBR927 NCBP1_HUMAN Increases Expression [8]
TP53-binding protein 1 (TP53BP1) OTL8879S TP53B_HUMAN Increases Expression [8]
Ankyrin-3 (ANK3) OTJ3IRBP ANK3_HUMAN Increases Expression [8]
TNF receptor-associated factor 1 (TRAF1) OTTLM5RU TRAF1_HUMAN Affects Expression [8]
PDZK1-interacting protein 1 (PDZK1IP1) OTWA6M5K PDZ1I_HUMAN Increases Expression [8]
Treacle protein (TCOF1) OT4BOYTM TCOF_HUMAN Decreases Expression [8]
Baculoviral IAP repeat-containing protein 3 (BIRC3) OT3E95KB BIRC3_HUMAN Affects Expression [8]
Baculoviral IAP repeat-containing protein 2 (BIRC2) OTFXFREP BIRC2_HUMAN Increases Expression [8]
Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) OTD1KRKO DYHC1_HUMAN Decreases Expression [8]
Enhancer of filamentation 1 (NEDD9) OTGCFN4M CASL_HUMAN Increases Expression [8]
Interferon regulatory factor 3 (IRF3) OT81U8ME IRF3_HUMAN Decreases Expression [8]
FXYD domain-containing ion transport regulator 3 (FXYD3) OT9PPRHE FXYD3_HUMAN Increases Expression [8]
Ankyrin repeat domain-containing protein 1 (ANKRD1) OTHJ7JV9 ANKR1_HUMAN Increases Expression [8]
Disks large homolog 2 (DLG2) OTQ3BD8U DLG2_HUMAN Increases Expression [8]
Cysteine and glycine-rich protein 2 (CSRP2) OT4SW0HI CSRP2_HUMAN Increases Expression [8]
Cyclin-G2 (CCNG2) OTII38K2 CCNG2_HUMAN Increases Expression [8]
Golgi-associated kinase 1B (GASK1B) OT2HPHEI GAK1B_HUMAN Decreases Expression [8]
SUZ domain-containing protein 1 (SZRD1) OTJMEJWT SZRD1_HUMAN Decreases Expression [8]
Leucine-rich repeat-containing protein 28 (LRRC28) OTFTT6VN LRC28_HUMAN Increases Expression [8]
Mitochondrial basic amino acids transporter (SLC25A29) OT09PIFE S2529_HUMAN Increases Expression [8]
Equilibrative nucleobase transporter 1 (SLC43A3) OTR60ZLA S43A3_HUMAN Decreases Expression [8]
Proprotein convertase subtilisin/kexin type 9 (PCSK9) OTI0DU9Y PCSK9_HUMAN Increases Expression [8]
E3 ubiquitin-protein ligase RNF149 (RNF149) OT6SBKQV RN149_HUMAN Increases Expression [8]
F-box only protein 25 (FBXO25) OTDFA7F4 FBX25_HUMAN Increases Expression [8]
Solute carrier family 2, facilitated glucose transporter member 14 (SLC2A14) OTBFIOVY GTR14_HUMAN Increases Expression [8]
Membrane progestin receptor beta (PAQR8) OTGZ8W9F PAQR8_HUMAN Increases Expression [8]
Nuclear receptor subfamily 4 group A member 3 (NR4A3) OTPBE9R1 NR4A3_HUMAN Increases Expression [8]
La-related protein 4B (LARP4B) OT2HI0QE LAR4B_HUMAN Increases Expression [8]
Collagen triple helix repeat-containing protein 1 (CTHRC1) OTV88X2G CTHR1_HUMAN Increases Expression [8]
BTB/POZ domain-containing protein KCTD12 (KCTD12) OTPYKT4Z KCD12_HUMAN Decreases Expression [8]
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (MAGI1) OTMV4ASV MAGI1_HUMAN Increases Expression [8]
Sialidase-1 (NEU1) OTH9BY8Y NEUR1_HUMAN Increases Expression [8]
Galactosylceramide sulfotransferase (GAL3ST1) OTSFFZRD G3ST1_HUMAN Decreases Expression [8]
Junctional adhesion molecule C (JAM3) OTX0F9QL JAM3_HUMAN Decreases Expression [8]
SLIT and NTRK-like protein 2 (SLITRK2) OTPVI22J SLIK2_HUMAN Increases Expression [8]
Anaphase-promoting complex subunit 1 (ANAPC1) OT2YY35L APC1_HUMAN Increases Expression [8]
Anthrax toxin receptor 1 (ANTXR1) OT5W1GPC ANTR1_HUMAN Affects Expression [8]
Ras-related GTP-binding protein D (RRAGD) OTXLVWAH RRAGD_HUMAN Increases Expression [8]
DNA damage-inducible transcript 4 protein (DDIT4) OTHY8SY4 DDIT4_HUMAN Affects Expression [8]
Intersectin-2 (ITSN2) OT8S0OO8 ITSN2_HUMAN Increases Expression [8]
Probable ribosome biogenesis protein RLP24 (RSL24D1) OT6KI56F RLP24_HUMAN Increases Expression [8]
Transcription elongation factor A protein-like 9 (TCEAL9) OT4UHDB5 TCAL9_HUMAN Increases Expression [8]
Histone deacetylase 9 (HDAC9) OTO8O0LF HDAC9_HUMAN Increases Expression [8]
Phosphoserine aminotransferase (PSAT1) OTVV1YV9 SERC_HUMAN Increases Expression [8]
Chloride intracellular channel protein 4 (CLIC4) OT6KTPKD CLIC4_HUMAN Increases Expression [8]
Alpha-2-macroglobulin (A2M) OTFTX90K A2MG_HUMAN Increases Expression [9]
Pro-epidermal growth factor (EGF) OTANRJ0L EGF_HUMAN Decreases Expression [9]
Insulin (INS) OTZ85PDU INS_HUMAN Increases Expression [9]
Lymphotoxin-alpha (LTA) OTUC3S76 TNFB_HUMAN Increases Expression [9]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Increases Expression [9]
Interferon gamma (IFNG) OTXG9JM7 IFNG_HUMAN Decreases Expression [9]
Interleukin-1 alpha (IL1A) OTPSGILV IL1A_HUMAN Decreases Expression [9]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Decreases Expression [9]
Serum amyloid P-component (APCS) OT76JZ8Z SAMP_HUMAN Decreases Expression [9]
Beta-2-glycoprotein 1 (APOH) OTFMUX6O APOH_HUMAN Increases Expression [9]
Alpha-fetoprotein (AFP) OT9GG3ZI FETA_HUMAN Decreases Expression [9]
Granulocyte-macrophage colony-stimulating factor (CSF2) OT1M7D28 CSF2_HUMAN Decreases Expression [9]
Interleukin-4 (IL4) OTOXBWAU IL4_HUMAN Decreases Expression [9]
Myeloperoxidase (MPO) OTOOXLIN PERM_HUMAN Increases Expression [9]
Endothelin-1 (EDN1) OTZCACEG EDN1_HUMAN Decreases Expression [9]
Intercellular adhesion molecule 1 (ICAM1) OTTOIX77 ICAM1_HUMAN Decreases Expression [9]
Stromelysin-1 (MMP3) OTGBI74Z MMP3_HUMAN Decreases Expression [9]
Coagulation factor VII (F7) OTGNJ97M FA7_HUMAN Decreases Expression [9]
Fibroblast growth factor 2 (FGF2) OT7YUJ9F FGF2_HUMAN Increases Expression [9]
Granulocyte colony-stimulating factor (CSF3) OT9GC6TP CSF3_HUMAN Decreases Expression [9]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Decreases Expression [9]
C-C motif chemokine 3 (CCL3) OTW2H3ND CCL3_HUMAN Increases Expression [9]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Decreases Expression [9]
Prostatic acid phosphatase (ACP3) OTSIM0YG PPAP_HUMAN Decreases Expression [9]
Kit ligand (KITLG) OTB9AVQ4 SCF_HUMAN Decreases Expression [9]
Interleukin-10 (IL10) OTIRFRXC IL10_HUMAN Decreases Expression [9]
Brain-derived neurotrophic factor (BDNF) OTLGH7EW BDNF_HUMAN Decreases Expression [9]
CD40 ligand (CD40LG) OT75Z6A6 CD40L_HUMAN Decreases Expression [9]
Interleukin-13 (IL13) OTI4YS3Y IL13_HUMAN Increases Expression [9]
Thrombopoietin (THPO) OTO73DZ2 TPO_HUMAN Increases Expression [9]
Interleukin-15 (IL15) OTQSYWQS IL15_HUMAN Decreases Expression [9]
Leptin (LEP) OT5Q7ODW LEP_HUMAN Decreases Expression [9]
Pappalysin-1 (PAPPA) OTTTG9PG PAPP1_HUMAN Decreases Expression [9]
Pro-interleukin-16 (IL16) OTZ2MO6B IL16_HUMAN Increases Expression [9]
Adiponectin (ADIPOQ) OTNX23LE ADIPO_HUMAN Increases Expression [9]
Aldehyde dehydrogenase 1A1 (ALDH1A1) OTCUWZKB AL1A1_HUMAN Decreases Expression [26]
Neurogenic locus notch homolog protein 1 (NOTCH1) OTI1WADQ NOTC1_HUMAN Increases Expression [26]
Proto-oncogene c-Rel (REL) OTTCKMAC REL_HUMAN Decreases Expression [26]
Telomerase reverse transcriptase (TERT) OT085VVA TERT_HUMAN Decreases Activity [27]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [28]
Nuclear protein 1 (NUPR1) OT4FU8C0 NUPR1_HUMAN Decreases Expression [29]
Collagen alpha-1(I) chain (COL1A1) OTI31178 CO1A1_HUMAN Decreases Expression [30]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Expression [31]
Insulin-like growth factor 1 receptor (IGF1R) OTXJIF13 IGF1R_HUMAN Decreases Expression [24]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Increases Expression [32]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [33]
Zinc finger protein GLI2 (GLI2) OTIRV97L GLI2_HUMAN Affects Expression [24]
Clusterin (CLU) OTQGG0JM CLUS_HUMAN Increases Expression [34]
G2/mitotic-specific cyclin-B1 (CCNB1) OT19S7E5 CCNB1_HUMAN Decreases Expression [24]
Serine/threonine-protein kinase B-raf (BRAF) OT7S81XQ BRAF_HUMAN Decreases Expression [24]
NAD(P)H dehydrogenase 1 (NQO1) OTZGGIVK NQO1_HUMAN Increases Expression [32]
CD44 antigen (CD44) OT9TTJ41 CD44_HUMAN Affects Expression [22]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Increases Expression [35]
Insulin-like growth factor-binding protein 3 (IGFBP3) OTIX63TX IBP3_HUMAN Affects Expression [24]
Cannabinoid receptor 1 (CNR1) OTEALO6G CNR1_HUMAN Increases Expression [36]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Increases Expression [37]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Increases Phosphorylation [25]
Aryl hydrocarbon receptor nuclear translocator (ARNT) OTMSIEZY ARNT_HUMAN Increases Expression [24]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Increases Phosphorylation [25]
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Increases Methylation [38]
Cannabinoid receptor 2 (CNR2) OTYP9P43 CNR2_HUMAN Increases Expression [36]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Increases Expression [39]
Breast cancer type 1 susceptibility protein (BRCA1) OT5BN6VH BRCA1_HUMAN Increases Expression [24]
Signal transducer and activator of transcription 3 (STAT3) OTAAGKYZ STAT3_HUMAN Decreases Activity [40]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Activity [41]
Proliferation marker protein Ki-67 (MKI67) OTA8N1QI KI67_HUMAN Decreases Expression [28]
Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) OTI2OREX MP2K3_HUMAN Increases Phosphorylation [42]
Transcription factor SOX-2 (SOX2) OTFAWCAU SOX2_HUMAN Increases Expression [39]
Glycogen synthase kinase-3 beta (GSK3B) OTL3L14B GSK3B_HUMAN Increases Phosphorylation [43]
Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6) OTK13JKC MP2K6_HUMAN Increases Phosphorylation [42]
Serine/threonine-protein kinase PLK1 (PLK1) OTRZX45T PLK1_HUMAN Decreases Expression [24]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Increases Activity [41]
BH3-interacting domain death agonist (BID) OTOSHSHU BID_HUMAN Increases Cleavage [44]
C-X-C chemokine receptor type 4 (CXCR4) OTUFSBX2 CXCR4_HUMAN Affects Expression [24]
E3 ubiquitin-protein ligase Mdm2 (MDM2) OTOVXARF MDM2_HUMAN Decreases Expression [24]
POU domain, class 5, transcription factor 1 (POU5F1) OTDHHN7O PO5F1_HUMAN Decreases Expression [22]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Increases Expression [45]
Regenerating islet-derived protein 3-alpha (REG3A) OT0BVQRB REG3A_HUMAN Decreases Expression [43]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [25]
Protein patched homolog 1 (PTCH1) OTMG07H5 PTC1_HUMAN Affects Expression [24]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Increases Activity [41]
Sonic hedgehog protein (SHH) OTOG2BXF SHH_HUMAN Decreases Expression [24]
Nuclear factor erythroid 2-related factor 2 (NFE2L2) OT0HENJ5 NF2L2_HUMAN Increases Expression [32]
Tumor protein p53-inducible nuclear protein 1 (TP53INP1) OT2363Z9 T53I1_HUMAN Increases Expression [43]
Protein smoothened (SMO) OTXXE208 SMO_HUMAN Increases Expression [39]
Homeobox protein NANOG (NANOG) OTUEY1FM NANOG_HUMAN Decreases Expression [39]
Axin-2 (AXIN2) OTRMGQNU AXIN2_HUMAN Affects Expression [24]
3',5'-cyclic-AMP phosphodiesterase 4D (PDE4D) OT1RWFV0 PDE4D_HUMAN Increases ADR [46]
Focal adhesion kinase 1 (PTK2) OT3Q1JDY FAK1_HUMAN Decreases Response To Substance [47]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Affects Response To Substance [48]
Splicing factor 45 (RBM17) OT9ROJCL SPF45_HUMAN Decreases Response To Substance [49]
Hypoxia-inducible factor 1-alpha (HIF1A) OTADSC03 HIF1A_HUMAN Affects Response To Substance [50]
Neuropilin-1 (NRP1) OTCGULYV NRP1_HUMAN Decreases Response To Substance [51]
Oxysterol-binding protein 2 (OSBP2) OTDGLB4J OSBP2_HUMAN Increases ADR [46]
Proto-oncogene tyrosine-protein kinase Src (SRC) OTETYX40 SRC_HUMAN Decreases Response To Substance [52]
Equilibrative nucleoside transporter 3 (SLC29A3) OTGLX8XU S29A3_HUMAN Affects Transport [53]
Probable ATP-dependent RNA helicase DDX53 (DDX53) OTHK3EGZ DDX53_HUMAN Affects Response To Substance [54]
Amphiregulin (AREG) OTJFOR67 AREG_HUMAN Decreases Response To Substance [55]
Pyruvate kinase PKM (PKM) OTLHHMC2 KPYM_HUMAN Affects Response To Substance [28]
Equilibrative nucleoside transporter 1 (SLC29A1) OTLOOZZS S29A1_HUMAN Increases Response To Substance [56]
Alpha-protein kinase 3 (ALPK3) OTLUYSMO ALPK3_HUMAN Increases ADR [46]
Transcription factor AP-2-alpha (TFAP2A) OTMYT3NK AP2A_HUMAN Increases Response To Substance [57]
Death-associated protein kinase 1 (DAPK1) OTNCNUCO DAPK1_HUMAN Increases ADR [58]
Cytochrome c oxidase subunit 3 (COX3) OTNNGBYJ COX3_HUMAN Decreases Response To Substance [59]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Decreases Response To Substance [60]
Receptor tyrosine-protein kinase erbB-2 (ERBB2) OTOAUNCK ERBB2_HUMAN Increases ADR [61]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Affects Response To Substance [62]
3-phosphoinositide-dependent protein kinase 1 (PDPK1) OTT09ZVP PDPK1_HUMAN Decreases Response To Substance [63]
Nucleophosmin (NPM1) OTTBYYT0 NPM_HUMAN Decreases Response To Substance [64]
Serine/threonine-protein kinase SMG1 (SMG1) OTTS3SXE SMG1_HUMAN Decreases Response To Substance [65]
ATP-dependent DNA helicase PIF1 (PIF1) OTUHKKVP PIF1_HUMAN Decreases Response To Substance [35]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Decreases Response To Substance [66]
Ribonucleoside-diphosphate reductase large subunit (RRM1) OTXGQOR9 RIR1_HUMAN Increases ADR [67]
Olfactory receptor 4D6 (OR4D6) OTXJKUT1 OR4D6_HUMAN Affects Response To Substance [54]
PDZ domain-containing protein GIPC1 (GIPC1) OTXLVCPJ GIPC1_HUMAN Affects Response To Substance [68]
Integrin-linked protein kinase (ILK) OTYG2FD1 ILK_HUMAN Affects Response To Substance [48]
Poly polymerase 2 (PARP2) OTYL81ZI PARP2_HUMAN Decreases Response To Substance [69]
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⏷ Show the Full List of 244 DOT(s)
Indication(s) of MK-2206
Disease Entry ICD 11 Status REF
Rectal adenocarcinoma 2B92 Phase 2 [6]
Nasopharyngeal carcinoma 2B6B Investigative [7]
MK-2206 Interacts with 2 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
RAC-gamma serine/threonine-protein kinase (AKT3) TTAZ05C AKT3_HUMAN Modulator [71]
E2 ubiquitin-conjugating enzyme T (UBE2T) TT0A1R8 UBE2T_HUMAN Inhibitor [7]
------------------------------------------------------------------------------------
MK-2206 Interacts with 20 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Increases Expression [72]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Decreases Secretion [70]
Receptor tyrosine-protein kinase erbB-2 (ERBB2) OTOAUNCK ERBB2_HUMAN Increases Expression [72]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Decreases Secretion [70]
Endothelin-1 (EDN1) OTZCACEG EDN1_HUMAN Decreases Expression [70]
Tissue factor (F3) OT3MSU3B TF_HUMAN Increases Expression [73]
Vascular endothelial growth factor receptor 1 (FLT1) OTT0OGYS VGFR1_HUMAN Decreases Expression [70]
Interleukin-10 (IL10) OTIRFRXC IL10_HUMAN Increases Secretion [70]
Endothelin receptor type B (EDNRB) OTLLZV3P EDNRB_HUMAN Increases Expression [70]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Affects Response To Substance [74]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Decreases Phosphorylation [75]
T-lymphocyte activation antigen CD80 (CD80) OTJBLUQE CD80_HUMAN Decreases Expression [70]
T-lymphocyte activation antigen CD86 (CD86) OTJCSBPC CD86_HUMAN Decreases Expression [70]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Cleavage [75]
CCAAT/enhancer-binding protein alpha (CEBPA) OTOM9OE4 CEBPA_HUMAN Decreases Expression [70]
Actin, aortic smooth muscle (ACTA2) OTEDLG8E ACTA_HUMAN Decreases Expression [76]
Small ribosomal subunit protein eS6 (RPS6) OTT4D1LN RS6_HUMAN Decreases Phosphorylation [75]
Interferon regulatory factor 8 (IRF8) OT8YSNI4 IRF8_HUMAN Decreases Expression [70]
Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1) OTHBQVD5 4EBP1_HUMAN Decreases Phosphorylation [75]
Proline-rich AKT1 substrate 1 (AKT1S1) OT4JHN4Y AKTS1_HUMAN Decreases Phosphorylation [77]
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⏷ Show the Full List of 20 DOT(s)

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Adenocarcinoma DC7QG7G CAOV3 Investigative [1]
Adenocarcinoma DCOLOC8 A427 Investigative [1]
Adenocarcinoma DC6OSVF NCIH2122 Investigative [1]
Adenocarcinoma DCVNLWT NCIH520 Investigative [1]
Adenocarcinoma DCZ9LSZ COLO320DM Investigative [1]
Adenocarcinoma DCUA1HB DLD1 Investigative [1]
Adenocarcinoma DCJ37TA HT29 Investigative [1]
Amelanotic melanoma DCIUG4I A2058 Investigative [1]
Germ cell tumour DCPSN36 PA1 Investigative [1]
Large cell lung carcinoma DC1RE8W NCI-H460 Investigative [1]
Malignant melanoma DCTJX70 RPMI7951 Investigative [1]
Mesothelioma DC9OA2U MSTO Investigative [1]
Non small cell carcinoma DCUZQPU SKMES1 Investigative [1]
Ovarian serous cystadenocarcinoma DCANSG1 SK-OV-3 Investigative [1]
Prostate carcinoma DCNZLDF VCAP Investigative [1]
Breast and ovarian cancer syndrome DC66O4S UWB1289 Investigative [78]
Breast and ovarian cancer syndrome DCH9HXV UWB1289+BRCA1 Investigative [78]
Breast carcinoma DCTUPR4 OCUBM Investigative [78]
Carcinoma DCXYQO8 EFM192B Investigative [78]
Carcinoma DCCWN1J MDAMB436 Investigative [78]
Colon carcinoma DCRUE7G RKO Investigative [78]
Invasive ductal carcinoma DCCB7TE T-47D Investigative [78]
Rectal adenocarcinoma DCIV6TH SW837 Investigative [78]
------------------------------------------------------------------------------------
⏷ Show the Full List of 23 DrugCom(s)

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