Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM3KJBC)

Drug Name
Epinephrine Drug Info
Synonyms
ADROP; Adnephrine; Adrenal; Adrenalin; Adrenalina; Adrenaline; Adrenalinum; Adrenamine; Adrenan; Adrenapax; Adrenasol; Adrenatrate; Adrenine; Adrenodis; Adrenohorma; Adrenosan; Adrenutol; Adrin; Adrine; Antiasthmatique; Asthmanefrin; Astmahalin; Astminhal; Balmadren; Bernarenin; Biorenine; Bosmin; Brevirenin; Bronkaid; Chelafrin; Corisol; Drenamist; Dylephrin; Epifrin; Epiglaufrin; Epinefrin; Epinefrina; Epinephran; Epinephrin; Epinephrinum; Epipen; Epirenamine; Epirenan; Epirenin; Epitrate; Eppy; Esphygmogenina; Exadrin; Glaucon; Glaucosan; Glauposine; Glycirenan; Haemostasin; Haemostatin; Hektalin; Hemisine; Hemostasin; Hemostatin; Hypernephrin; Hyporenin; IOP; Intranefrin; Iontocaine; Isoptoepinal; Kidoline; Levoadrenaline; Levoepinephrine; Levorenen; Levorenin; Levorenine; Lyophrin; Metanephrin; Methylaminoethanolcatechol; Methylarterenol; Micronefrin; Micronephrine; Mucidrina; Myosthenine; Mytrate; Nephridine; Nieraline; Paranephrin; Primatene; Racepinephrine; Renagladin; Renaglandin; Renaglandulin; Renaleptine; Renalina; Renoform; Renostypricin; Renostypticin; Renostyptin; Scurenaline; Septocaine; Simplene; Sindrenina; Soladren; Sphygmogenin; Stryptirenal; Styptirenal; Supracapsulin; Supradin; Supranefran; Supranephrane; Supranephrine; Supranol; Suprarenaline; Suprarenin; Suprel; Surenine; Surrenine; Susphrine; Takamina; Takamine; Tokamina; Tonogen; Twinject; Vaponefrin; Vasoconstrictine; Vasoconstrictor; Vasodrine; Vasoton; Vasotonin; ADR ADRENALINE; Adrenalin in Oil; Adrenalina [DCIT]; Asmatane Mist; Asthma meter mist; Asthmahaler Mist; Bronkaid Mist; Bronkaid Suspension Mist; Bupivacaine Hcl and Epinephrine; Citanest Forte; EPI E Z PEN JR; EPIPEN E Z PEN; EPIPEN JR; Epi EZ Pen Jr; Epinefrin [Czech]; Epinephrine hydrochloride; Epipen EZ Pen; Primatene Mist; Racemic Epinephrine; Sympathin I; Adrenalin (TN); Adrenalin-Medihaler; Adrenaline (JP15); Adrenaline/Epinephrine; Ana-Guard; Asthma-nefrin; D-Adrenaline; D-Epifrin; D-Epinephrine; Dyspne-Inhal; Epinefrina [INN-Spanish]; Epinephrine (USP); Epinephrinum [INN-Latin]; Epipen (TN); Epipen Auto-Injector; Epipen Jr.; L-Adrenalin; L-Adrenaline; L-Adrenaline Base; L-Epinehphrine; L-Epinephine; L-Epirenamine; L-Methylaminoethanolcatechol; L-epinephrine; Levo-Methylaminoethanolcatechol; Medihaler-Epi; R-Adrenaline; Sus-Phrine; Twinject 0.15; Twinject 0.3; Twinject 0.30; Epinephrine (USP/INN); Epinephrine [USAN:INN:JAN]; Epipen Jr. Auto-Injector; L-Epinephrine (synthetic); SUS-PHRINE SULFITE-FREE; R-(-)-Epinephrine; L-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol; (-)-(R)-Epinephrine; (-)-3,4-Dihydroxy-alpha-((methylamino)methyl)benzyl alcohol; (-)-Adrenalin; (-)-Adrenaline; (-)-R-Epinephrine; (R)-(-)-Adnephrine; (R)-(-)-Adrenaline; (R)-(-)-Epinephrine; (R)-(-)-Epirenamine; (R)-4-[1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol; (R)-Adrenaline; (R)-Epinephrine; 1-1-(3,4-Dihydroxyphenyl)-2-methylaminoethanol; 1-Adrenalin; 1-Epinephrine; 4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-benzenediol; 4-(1-hydroxy-2-methylamino-ethyl)benzene-1,2-diol; 4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol; 4-[(1R)-1-hydroxy-2-(methylamino)ethyl]benzene-1,2-diol
Indication
Disease Entry ICD 11 Status REF
Acute asthma CA23 Approved [1]
Allergy 4A80-4A85 Approved [2]
Anaphylaxis Approved [1]
Bronchiectasis CA24 Approved [1]
Bronchitis CA20 Approved [1]
Periodontitis DA0C Approved [1]
Pulmonary emphysema CA21.Z Approved [1]
Severe asthma CA23 Approved [1]
Asthma CA23 Investigative [1]
Therapeutic Class
Vasoconstrictor Agents
Cross-matching ID
PubChem CID
5816
ChEBI ID
CHEBI:28918
CAS Number
CAS 51-43-4
TTD Drug ID
DM3KJBC
VARIDT Drug ID
DR00076
INTEDE Drug ID
DR0590
ACDINA Drug ID
D00234

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Adrenergic receptor beta-1 (ADRB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Propranolol DM79NTF Angina pectoris BA40 Approved [19]
Norepinephrine DMOUC09 Alopecia ED70 Approved [20]
Atenolol DMNKG1Z Angina pectoris BA40 Approved [21]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [21]
Metoprolol DMOJ0V6 Acute coronary syndrome BA41 Approved [21]
Timolol DM3NXRU High blood pressure BA00 Approved [22]
Isoproterenol DMK7MEY Atrioventricular block Approved [23]
Betaxolol DM6EUL5 Hypertension BA00-BA04 Approved [24]
Sotalol DML60TN Sinus rhythm disorder BC9Y Approved [25]
Nadolol DMW6GVL Angina pectoris BA40 Approved [26]
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Drug(s) Transported By Organic cation transporter 3 (SLC22A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Propranolol DM79NTF Angina pectoris BA40 Approved [27]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [4]
Metformin DM89QE1 Colorectal carcinoma Approved [28]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [27]
Entecavir DM7VTQO Hepatitis B virus infection 1E51.0 Approved [29]
Norepinephrine DMOUC09 Alopecia ED70 Approved [4]
Amphetamine DMSZQAK Attention deficit hyperactivity disorder 6A05.Z Approved [30]
Acetylcholine DMDF79Z Cataract 9B10 Approved [31]
Sodium chloride DMM3950 Skin burns ME65.0 Approved [32]
Etilefrine DM67PWD Cardiovascular disease BA00-BE2Z Withdrawn from market [33]
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Drug(s) Transported By Organic cation transporter 1 (SLC22A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [34]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [35]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [36]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [37]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [5]
Verapamil DMA7PEW Angina pectoris BA40 Approved [38]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [39]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [40]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [41]
Propranolol DM79NTF Angina pectoris BA40 Approved [27]
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Drug(s) Metabolized By UDP-glucuronosyltransferase 1A1 (UGT1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [42]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [43]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [44]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [45]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [46]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [47]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [48]
Metronidazole DMTIVEN Abscess Approved [49]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [50]
Ethanol DMDRQZU Chronic pain MG30 Approved [51]
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Drug(s) Metabolized By Sulfotransferase 1A1 (SULT1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [52]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [53]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [54]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [55]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [56]
Warfarin DMJYCVW Atrial fibrillation BC81.3 Approved [57]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [58]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [59]
Benzyl alcohol DMBVYDI Head and body lice 1G00.0 Approved [60]
Teicoplanin DMAQ2LK Bacterial infection 1A00-1C4Z Approved [61]
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Drug(s) Metabolized By Thiopurine methyltransferase (TPMT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [62]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [63]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [64]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [65]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [66]
Vitamin C DMXJ7O8 Adenocarcinoma 2D40 Approved [67]
Cefazolin DMPDYFR Bacteremia 1A73 Approved [68]
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [69]
Thioguanine DM7NKEV Acute lymphocytic leukaemia 2B33.3 Approved [70]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [71]
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Drug(s) Metabolized By Catechol O-methyltransferase (COMT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [72]
Dobutamine DMD1B8Z Heart failure BD10-BD13 Approved [73]
METHYLENEDIOXYMETHAMPHETAMINE DMYVU47 Discovery agent N.A. Investigative [74]
Dobutamine DMD1B8Z Heart failure BD10-BD13 Approved [18]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [18]
Modafinil DMYILBE Malignant glioma 2A00.0 Approved [80]
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [18]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [81]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Tolcapone DM8MNVO Parkinson disease 8A00.0 Approved [84]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [86]
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Drug(s) Metabolized By Monoamine oxidase type A (MAO-A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zolmitriptan DM1IB4Q Migraine 8A80 Approved [75]
Naratriptan DMO50U2 Headache 8A80-8A84 Approved [76]
Safinamide mesylate DM0J2ZT Parkinson disease 8A00.0 Approved [77]
Almotriptan malate DMFG5ST N. A. N. A. Approved [78]
SEROTONIN DMOFCRY Discovery agent N.A. Investigative [79]
PHENETHYLAMINE DMX0G4F Discovery agent N.A. Investigative [79]
Benzylamine DMRM6ES N. A. N. A. Investigative [79]
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Drug(s) Affected By Solute carrier family 22 member 3 (SLC22A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [87]
Norepinephrine DMOUC09 Alopecia ED70 Approved [87]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [88]
Quercetin DM3NC4M Obesity 5B81 Approved [89]
Phenoxybenzamine DM8KSQH Malignant essential hypertension BA00 Approved [90]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [91]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [92]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [93]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [94]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [95]
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Drug(s) Affected By Superoxide dismutase (SOD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [96]
Haloperidol DM96SE0 Delirium Approved [12]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [97]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [98]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [99]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [100]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [101]
Methotrexate DM2TEOL Anterior urethra cancer Approved [102]
Quercetin DM3NC4M Obesity 5B81 Approved [103]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [104]
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Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [105]
Selenium DM25CGV N. A. N. A. Approved [106]
Methotrexate DM2TEOL Anterior urethra cancer Approved [107]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [108]
Quercetin DM3NC4M Obesity 5B81 Approved [109]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [110]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [111]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [112]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [113]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [107]
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Drug(s) Affected By Carbonic anhydrase 2 (CA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetazolamide DM1AF5U Absence epilepsy Approved [114]
Quercetin DM3NC4M Obesity 5B81 Approved [89]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [113]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [115]
Methazolamide DM7J2TA Glaucoma/ocular hypertension 9C61 Approved [116]
Topiramate DM82Z30 Alcohol dependence 6C40.2 Approved [117]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [118]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [119]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [91]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [120]
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Drug(s) Affected By Integrin alpha-V (ITGAV)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [82]
Quercetin DM3NC4M Obesity 5B81 Approved [89]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [121]
Testosterone DM7HUNW Hot flushes GA30 Approved [122]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [123]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [124]
Testosterone enanthate DMB6871 N. A. N. A. Approved [125]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [86]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [126]
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Drug(s) Affected By Cathepsin K (CTSK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [127]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [128]
Testosterone DM7HUNW Hot flushes GA30 Approved [122]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [129]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [124]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [130]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [131]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [132]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [133]
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Drug(s) Affected By Renin (REN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [134]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [135]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [136]
Reboxetine DM26PRD Depression 6A70-6A7Z Approved [137]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [138]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [139]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [140]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [141]
Chlorthalidone DM4DMBT Edema MG29 Approved [142]
Trandolapril DM4L6EU Chronic heart failure BD1Z Approved [143]
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Drug(s) Affected By Insulin (INS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [144]
Methotrexate DM2TEOL Anterior urethra cancer Approved [145]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [146]
Fructose DM43AN2 Vomiting MD90 Approved [147]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [148]
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [149]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [150]
Propranolol DM79NTF Angina pectoris BA40 Approved [151]
Testosterone DM7HUNW Hot flushes GA30 Approved [152]
Glibenclamide DM8JXPZ Diabetic complication 5A2Y Approved [149]
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Drug(s) Affected By Beta-2 adrenergic receptor (ADRB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salmeterol DMIEU69 Allergic asthma CA23.0 Approved [153]
Bambuterol DMKLSHF Asthma CA23 Approved [154]
Terbutaline DMD4381 Asthma CA23 Approved [155]
Salbutamol DMN9CWF Acute asthma CA23 Approved [156]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [157]
Methotrexate DM2TEOL Anterior urethra cancer Approved [158]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [128]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [159]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [160]
Propranolol DM79NTF Angina pectoris BA40 Approved [161]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [162]
Gefitinib DM15F0X Colon adenocarcinoma Approved [163]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [165]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [166]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [167]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [166]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [168]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [169]
Methotrexate DM2TEOL Anterior urethra cancer Approved [170]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [171]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [172]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [173]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [174]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [12]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [162]
Verapamil DMA7PEW Angina pectoris BA40 Approved [175]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [176]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [177]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [178]
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Drug(s) Affected By Proliferating cell nuclear antigen (PCNA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [162]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [179]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [180]
Selenium DM25CGV N. A. N. A. Approved [181]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [182]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [183]
Meloxicam DM2AR7L Arthritis FA20 Approved [184]
Methotrexate DM2TEOL Anterior urethra cancer Approved [185]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [186]
Quercetin DM3NC4M Obesity 5B81 Approved [187]
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Drug(s) Affected By Pyruvate kinase PKM (PKM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [188]
Selenium DM25CGV N. A. N. A. Approved [189]
Quercetin DM3NC4M Obesity 5B81 Approved [89]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [190]
Panobinostat DM58WKG Chronic graft versus host disease Approved [191]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [192]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [193]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [194]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [195]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [196]
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Drug(s) Affected By Alpha-1D adrenergic receptor (ADRA1D)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Alfuzosin DMZVMKF Benign prostatic hyperplasia GA90 Approved [197]
Verapamil DMA7PEW Angina pectoris BA40 Approved [198]
Oxymetazoline DM8ZXT6 Arrhythmia BC9Z Approved [199]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
Terbutaline DMD4381 Asthma CA23 Approved [200]
Methoxamine DMF5XQH Hypertension BA00-BA04 Approved [199]
Quinidine DMLPICK N. A. N. A. Approved [198]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [200]
Norepinephrine DMOUC09 Alopecia ED70 Approved [199]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [201]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [97]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [202]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [165]
Methotrexate DM2TEOL Anterior urethra cancer Approved [203]
Quercetin DM3NC4M Obesity 5B81 Approved [204]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [205]
Fructose DM43AN2 Vomiting MD90 Approved [206]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [97]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [207]
Vismodegib DM5IXKQ Basal cell carcinoma 2C32 Approved [208]
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Drug(s) Affected By Alpha-1A adrenergic receptor (ADRA1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamsulosin DM5QF9V Benign prostatic hyperplasia GA90 Approved [209]
SILODOSIN DMJSBT6 Benign prostatic hyperplasia GA90 Approved [11]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [12]
Verapamil DMA7PEW Angina pectoris BA40 Approved [198]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [210]
Oxymetazoline DM8ZXT6 Arrhythmia BC9Z Approved [209]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [91]
Quinidine DMLPICK N. A. N. A. Approved [198]
Norepinephrine DMOUC09 Alopecia ED70 Approved [197]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [211]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Alpha-1B adrenergic receptor (ADRA1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [198]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [212]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [118]
Oxymetazoline DM8ZXT6 Arrhythmia BC9Z Approved [213]
Terbutaline DMD4381 Asthma CA23 Approved [200]
Quinidine DMLPICK N. A. N. A. Approved [198]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [200]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [214]
Arsenic DMTL2Y1 N. A. N. A. Approved [215]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [216]
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Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [217]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [218]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [219]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [220]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [221]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [222]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [223]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [224]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [225]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [226]
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Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [227]
Gefitinib DM15F0X Colon adenocarcinoma Approved [228]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [229]
Quercetin DM3NC4M Obesity 5B81 Approved [230]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [104]
Fructose DM43AN2 Vomiting MD90 Approved [206]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [231]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [232]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [233]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [234]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hexokinase-2 (HK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [235]
Quercetin DM3NC4M Obesity 5B81 Approved [89]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [128]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [236]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [237]
Leflunomide DMR8ONJ Arthritis FA20 Approved [238]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [124]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [239]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [240]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ephrin type-A receptor 4 (EPHA4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [241]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Panobinostat DM58WKG Chronic graft versus host disease Approved [191]
Estrone DM5T6US Acne vulgaris ED80 Approved [241]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [242]
Testosterone DM7HUNW Hot flushes GA30 Approved [122]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [91]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
Mestranol DMG3F94 Contraception QA21 Approved [241]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [243]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hormone-sensitive lipase (LIPE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [244]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [245]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [246]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [247]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [131]
Vitamin B3 DMQVRZH Chronic renal failure GB61.Z Approved [248]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [214]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [133]
CS-038 DM67P0F Type-2 diabetes 5A11 Phase 3 [247]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [249]
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Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [250]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [251]
Prednisone DM2HG4X Acute asthma CA23 Approved [252]
Triamterene DM2HU9I Congestive heart failure BD10 Approved [252]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [253]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [254]
Quercetin DM3NC4M Obesity 5B81 Approved [204]
Fluoxetine DM3PD2C Bipolar depression Approved [255]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [256]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [257]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By P2X purinoceptor 7 (P2RX7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [257]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [258]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [91]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [211]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [259]
AZ11645373 DMDRXCP Discovery agent N.A. Investigative [260]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [261]
BzATP DM37GYA Discovery agent N.A. Investigative [262]
Milchsaure DM462BT Pruritus EC90 Investigative [263]
Ethidium DMMEQUR Discovery agent N.A. Investigative [264]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Leptin (LEP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [265]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [266]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [267]
Quercetin DM3NC4M Obesity 5B81 Approved [268]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [269]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [265]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [265]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [270]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [271]
Amlodipine DMBDAZV Angina pectoris BA40 Approved [272]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Catalase (CAT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [99]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [273]
Haloperidol DM96SE0 Delirium Approved [12]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [274]
Selenium DM25CGV N. A. N. A. Approved [275]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [276]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [277]
Methotrexate DM2TEOL Anterior urethra cancer Approved [145]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [278]
Quercetin DM3NC4M Obesity 5B81 Approved [89]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sulfotransferase 1A3 (SULT1A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [211]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [279]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
Ethanol DMDRQZU Chronic pain MG30 Approved [280]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [281]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [282]
Vitamin C DMXJ7O8 Adenocarcinoma 2D40 Approved [283]
Benzyl alcohol DMBVYDI Head and body lice 1G00.0 Approved [60]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [284]
Estrone DM5T6US Acne vulgaris ED80 Approved [285]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutathione reductase, mitochondrial (GSR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [286]
Ketoprofen DMRKXPT Bursitis Approved [12]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [274]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [287]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [288]
Quercetin DM3NC4M Obesity 5B81 Approved [289]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [111]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [290]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [291]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [292]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neuron-specific vesicular protein calcyon (CALY)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [293]
Sodium chloride DMM3950 Skin burns ME65.0 Approved [294]
Norepinephrine DMOUC09 Alopecia ED70 Approved [294]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [294]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [259]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [295]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [296]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [297]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [298]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [299]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [300]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [301]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [99]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [302]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [301]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Equilibrative nucleoside transporter 4 (SLC29A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [87]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [257]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [303]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [304]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [305]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [243]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [306]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [214]
Norepinephrine DMOUC09 Alopecia ED70 Approved [87]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Alpha-2A adrenergic receptor (ADRA2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [307]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [12]
Rilmenidine DM13PQW Hypertension BA00-BA04 Approved [308]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [121]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [309]
Oxymetazoline DM8ZXT6 Arrhythmia BC9Z Approved [213]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [310]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [85]
Indapamide DMGN1PW Edema MG29 Approved [311]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Adrenergic receptor beta-1 (ADRB1) TTR6W5O ADRB1_HUMAN Agonist [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Organic cation transporter 3 (SLC22A3) DT6201N S22A3_HUMAN Substrate [4]
Organic cation transporter 1 (SLC22A1) DTT79CX S22A1_HUMAN Substrate [5]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Substrate [6]
Sulfotransferase 1A1 (SULT1A1) DEYWLRK ST1A1_HUMAN Substrate [7]
Monoamine oxidase type A (MAO-A) DERE4TU AOFA_HUMAN Substrate [8]
Catechol O-methyltransferase (COMT) DEV3T4A COMT_HUMAN Substrate [9]
Thiopurine methyltransferase (TPMT) DEFQ8VO TPMT_HUMAN Substrate [10]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Alpha-1A adrenergic receptor (ADRA1A) OTUIWCL5 ADA1A_HUMAN Gene/Protein Processing [11]
Alpha-1B adrenergic receptor (ADRA1B) OTSAYAFD ADA1B_HUMAN Gene/Protein Processing [11]
Alpha-1D adrenergic receptor (ADRA1D) OTW2CD1O ADA1D_HUMAN Gene/Protein Processing [11]
Alpha-2A adrenergic receptor (ADRA2A) OTZFGOTP ADA2A_HUMAN Drug Response [12]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [13]
Beta-2 adrenergic receptor (ADRB2) OTSDOX4Q ADRB2_HUMAN Gene/Protein Processing [14]
Carbonic anhydrase 2 (CA2) OTJRMUAG CAH2_HUMAN Gene/Protein Processing [15]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [16]
Catalase (CAT) OTHEBX9R CATA_HUMAN Drug Response [17]
Catechol O-methyltransferase (COMT) OTPWKTQG COMT_HUMAN Biotransformations [18]

References

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4 Differential pharmacological in vitro properties of organic cation transporters and regional distribution in rat brain. Neuropharmacology. 2006 Jun;50(8):941-52.
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25 beta(2)-adrenoceptors are critical for antidepressant treatment of neuropathic pain. Ann Neurol. 2009 Feb;65(2):218-25.
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28 Expression of organic cation transporters OCT1 (SLC22A1) and OCT3 (SLC22A3) is affected by genetic factors and cholestasis in human liver. Hepatology. 2009 Oct;50(4):1227-40.
29 Multiple SLC and ABC Transporters Contribute to the Placental Transfer of Entecavir. Drug Metab Dispos. 2017 Mar;45(3):269-278.
30 Interaction of organic cation transporter 3 (SLC22A3) and amphetamine. J Neurochem. 2010 Jul;114(1):142-9.
31 Organic cation transporters: physiology, toxicology and special focus on ethidium as a novel substrate. Curr Drug Metab. 2009 Jul;10(6):617-31.
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34 Are organic cation transporters capable of transporting prostaglandins? Naunyn Schmiedebergs Arch Pharmacol. 2005 Aug;372(2):125-30.
35 Cisplatin and oxaliplatin, but not carboplatin and nedaplatin, are substrates for human organic cation transporters (SLC22A1-3 and multidrug and toxin extrusion family). J Pharmacol Exp Ther. 2006 Nov;319(2):879-86.
36 Pharmacologic markers and predictors of responses to imatinib therapy in patients with chronic myeloid leukemia. Leuk Lymphoma. 2008 Apr;49(4):639-42.
37 Organic cation transporters are determinants of oxaliplatin cytotoxicity. Cancer Res. 2006 Sep 1;66(17):8847-57.
38 Implications of genetic polymorphisms in drug transporters for pharmacotherapy. Cancer Lett. 2006 Mar 8;234(1):4-33.
39 Upregulation of histone acetylation reverses organic anion transporter 2 repression and enhances 5-fluorouracil sensitivity in hepatocellular carcinoma
40 Comparison of type I and type II organic cation transport by organic cation transporters and organic anion-transporting polypeptides. J Pharmacol Exp Ther. 2001 Jul;298(1):110-5.
41 Organic cation transporters and their pharmacokinetic and pharmacodynamic consequences. Drug Metab Pharmacokinet. 2008;23(4):243-53.
42 Functional significance of UDP-glucuronosyltransferase variants in the metabolism of active tamoxifen metabolites. Cancer Res. 2009 Mar 1;69(5):1892-900.
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44 Effect of UDP-glucuronosyltransferase (UGT) 1A polymorphism (rs8330 and rs10929303) on glucuronidation status of acetaminophen. Dose Response. 2017 Sep 11;15(3):1559325817723731.
45 UDP-glucuronosyltransferase 1A1 is the principal enzyme responsible for etoposide glucuronidation in human liver and intestinal microsomes: structural characterization of phenolic and alcoholic glucuronides of etoposide and estimation of enzyme kinetics. Drug Metab Dispos. 2007 Mar;35(3):371-80.
46 Interindividual variability in pharmacokinetics of generic nucleoside reverse transcriptase inhibitors in TB/HIV-coinfected Ghanaian patients: UGT2B7*1c is associated with faster zidovudine clearance and glucuronidation. J Clin Pharmacol. 2009 Sep;49(9):1079-90.
47 Effect of aging on glucuronidation of valproic acid in human liver microsomes and the role of UDP-glucuronosyltransferase UGT1A4, UGT1A8, and UGT1A10. Drug Metab Dispos. 2009 Jan;37(1):229-36.
48 Characterization of rat intestinal microsomal UDP-glucuronosyltransferase activity toward mycophenolic acid. Drug Metab Dispos. 2006 Sep;34(9):1632-9.
49 Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios. Drug Metab Dispos. 2004 Nov;32(11):1201-8.
50 Substrate-dependent modulation of UDP-glucuronosyltransferase 1A1 (UGT1A1) by propofol in recombinant human UGT1A1 and human liver microsomes. Basic Clin Pharmacol Toxicol. 2007 Sep;101(3):211-4.
51 Identification and preliminary characterization of UDP-glucuronosyltransferases catalyzing formation of ethyl glucuronide. Anal Bioanal Chem. 2014 Apr;406(9-10):2325-32.
52 Progestagenic effects of tibolone are target gene-specific in human endometrial cells. J Soc Gynecol Investig. 2006 Sep;13(6):459-65.
53 Tamoxifen-induced adduct formation and cell stress in human endometrial glands. Drug Metab Dispos. 2010 Jan;38(1):200-7.
54 Proposed role of the sulfotransferase/sulfatase pathway in modulating yolk steroid effects. Integr Comp Biol. 2008 Sep;48(3):419-27.
55 Interindividual variability in acetaminophen sulfation by human fetal liver: implications for pharmacogenetic investigations of drug-induced birth defects. Birth Defects Res A Clin Mol Teratol. 2008 Mar;82(3):155-65.
56 Inhibition of human phenol and estrogen sulfotransferase by certain non-steroidal anti-inflammatory agents. Curr Drug Metab. 2006 Oct;7(7):745-53.
57 Natural products isolated from Mexican medicinal plants: novel inhibitors of sulfotransferases, SULT1A1 and SULT2A1. Phytomedicine. 2001 Nov;8(6):481-8.
58 Kinetic analysis of bile acid sulfation by stably expressed human sulfotransferase 2A1 (SULT2A1). Xenobiotica. 2010 Mar;40(3):184-94.
59 Characterization of human liver thermostable phenol sulfotransferase (SULT1A1) allozymes with 3,3',5-triiodothyronine as the substrate. J Endocrinol. 2001 Dec;171(3):525-32.
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