Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNH3PG)

Drug Name
Etoposide Drug Info
Synonyms
etoposide; 33419-42-0; VePesid; Toposar; trans-Etoposide; Lastet; (-)-Etoposide; Zuyeyidal; Etoposidum; Etoposido; Vepesid J; Eposin; Etoposidum [INN-Latin]; Etoposide (VP16); VP 16-213; VP 16 (pharmaceutical); Etoposido [INN-Spanish]; Etopophos (phosphate salt); VP-16-213; 4-Demethylepipodophyllotoxin beta-D-ethylideneglucoside; VP 16213; UNII-6PLQ3CP4P3; NK 171; NSC 141540; CCRIS 2392; HSDB 6517; 4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylidene-beta-D-glucopyranoside); EINECS 251-509-1; NSC-141540; Eposide; Etopol; Etosid; Vepeside; Demethyl EpipodophyllotoxinEthylidine Glucoside; E0675; Demethyl-epiodophyllotoxin ethylidene glucoside; Epipodophyllotoxin VP-16213; Eposin (TN); Etopophos (TN); Trans-Etoposide; VePESID (TN); Vepesid (TN); DEMETHY-EPIPODOPHYLLOTOXIN, ETHYLIDENE GLUCOSIDE; VP-16 (TN); Demethylepipodophyllotoxin-beta-D-ethylideneglucoside; Etoposide (JP15/USP/INN); Etoposide [USAN:INN:BAN:JAN]; Eposin, Vepesid, VP-16, Toposar, Etoposide; Epipodophyllotoxin, 4'-demethyl-, 4,6-O-ethylidene-beta-D-glucopyranoside; Epipodophyllotoxin, 4'-demethyl-, 4,6-O-ethylidene-beta-D-glucopyranoside (8CI); Epipodophyllotoxin, 4'-demethyl-, 9-(4,6-O-ethylidene-beta-D-glucopyranoside); 4'-Demethyl-epipodophyllotoxin 9-[4,6-O-(R)-ethylidene-beta-D-glucopyranoside; 4'-Demethylepipodophyllotoxin 9-(4,6-O-ethylidene-beta-D-glucopyranoside); 4'-Demethylepipodophyllotoxin ethylidene-beta-D-glucoside; 4'-O-Demethyl-1-O-(4,6-O-ethylidene-beta-D-glucopyranosyl)epipodophyllotoxin; 4-Demethylepipodophyllotoxin-beta-D-ethylideneglucoside
Indication
Disease Entry ICD 11 Status REF
Acute myelogenous leukaemia 2A41 Approved [1]
Adult acute monocytic leukemia Approved [1]
Adult kidney Wilms tumor Approved [1]
Beckwith-Wiedemann syndrome Approved [1]
Childhood kidney Wilms tumor Approved [1]
Hamartoma Approved [1]
Kidney neoplasm Approved [1]
Lung cancer 2C25.0 Approved [1]
Non-small-cell lung cancer 2C25.Y Approved [1]
Plasma cell myeloma 2A83.1 Approved [1]
Small-cell lung cancer 2C25.Y Approved [1]
Solid tumour/cancer 2A00-2F9Z Approved [2]
Testicular cancer 2C80 Approved [3]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 2 [4]
Neuroblastoma 2D11.2 Investigative [1]
Therapeutic Class
Anticancer Agents
Cross-matching ID
PubChem CID
36462
ChEBI ID
CHEBI:4911
CAS Number
CAS 33419-42-0
TTD Drug ID
DMNH3PG
VARIDT Drug ID
DR00162
INTEDE Drug ID
DR0669
ACDINA Drug ID
D00258

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Patented Agent(s)
Discontinued Drug(s)
Preclinical Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting DNA topoisomerase II (TOP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [24]
Teniposide DMLW57T Acute lymphoblastic leukaemia 2A85 Approved [24]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [25]
Idarubicin DMM0XGL Acute myelogenous leukaemia 2A41 Approved [24]
Epirubicin DMPDW6T Solid tumour/cancer 2A00-2F9Z Approved [24]
Lomefloxacin DMVRH9C Bacterial infection 1A00-1C4Z Approved [26]
Dexrazoxane DMD7X1O Breast cancer 2C60-2C65 Approved [24]
Podofilox DMT2EJP Condyloma 1A95 Approved [27]
Enoxacin DMYTE6L Acute gonococcal cervicitis Approved [28]
Amsacrine DMZKYIV Acute lymphoblastic leukaemia 2A85 Approved [29]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Multidrug resistance-associated protein 1 (ABCC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [30]
Methotrexate DM2TEOL Anterior urethra cancer Approved [31]
Folic Acid DMEMBJC Colorectal carcinoma Approved [32]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [33]
Verapamil DMA7PEW Angina pectoris BA40 Approved [34]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [35]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [36]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [37]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [38]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [34]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [210]
Folic Acid DMEMBJC Colorectal carcinoma Approved [32]
Methotrexate DM2TEOL Anterior urethra cancer Approved [211]
Quercetin DM3NC4M Obesity 5B81 Approved [212]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [213]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [214]
Epirubicin DMPDW6T Solid tumour/cancer 2A00-2F9Z Approved [215]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [216]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [217]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [217]
⏷ Show the Full List of 20 Drug(s)
Drug(s) Transported By Multidrug resistance-associated protein 2 (ABCC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [39]
Methotrexate DM2TEOL Anterior urethra cancer Approved [40]
Folic Acid DMEMBJC Colorectal carcinoma Approved [41]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [42]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [43]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [44]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [45]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [46]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [47]
Ampicillin DMHWE7P Acute epiglottitis Approved [48]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [34]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [49]
Methotrexate DM2TEOL Anterior urethra cancer Approved [48]
Folic Acid DMEMBJC Colorectal carcinoma Approved [50]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [48]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [48]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [51]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [48]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [52]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [53]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Breast cancer resistance protein (ABCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [54]
Methotrexate DM2TEOL Anterior urethra cancer Approved [55]
Folic Acid DMEMBJC Colorectal carcinoma Approved [56]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [57]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [58]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [59]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [60]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [59]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [61]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [62]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Organic anion transporting polypeptide 1B1 (SLCO1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [63]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [64]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [65]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [65]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [66]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [67]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [68]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [69]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [66]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [70]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Multidrug resistance-associated protein 3 (ABCC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [71]
Folic Acid DMEMBJC Colorectal carcinoma Approved [31]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [72]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [73]
Glibenclamide DM8JXPZ Diabetic complication 5A2Y Approved [74]
Morphine DMRMS0L Advanced cancer 2A00-2F9Z Approved [75]
Cefadroxil DMMC345 Bacterial infection 1A00-1C4Z Approved [76]
Teniposide DMLW57T Acute lymphoblastic leukaemia 2A85 Approved [77]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [78]
Efavirenz DMC0GSJ Human immunodeficiency virus infection 1C62 Approved [79]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Organic anion transporting polypeptide 1B3 (SLCO1B3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [80]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [65]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [81]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [65]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [82]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [67]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [69]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [83]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [69]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [84]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Transported By Organic anion transporting polypeptide 2B1 (SLCO2B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [85]
L-Glutamic Acid DM4PUDW Schizophrenia 6A20 Approved [86]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [87]
Pravastatin DM6A0X7 Adult acute monocytic leukemia Approved [88]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [89]
Cerivastatin DMXCM7H Hyperlipidaemia 5C80 Approved [90]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [91]
Digoxin DMQCTIH Arrhythmia BC9Z Approved [92]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [70]
Fluvastatin DM4MDJY Arteriosclerosis BD40 Approved [93]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [94]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [95]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [96]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [97]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [98]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [99]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [100]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [95]
Verapamil DMA7PEW Angina pectoris BA40 Approved [101]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [102]
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [159]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [160]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [161]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [162]
Proguanil DMBL79I Malaria 1F40-1F45 Approved [163]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [163]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [164]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [165]
Capsaicin DMGMF6V Back pain ME84.Z Approved [166]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [167]
⏷ Show the Full List of 20 Drug(s)
Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [103]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [104]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [105]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [106]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [107]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [108]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [109]
Verapamil DMA7PEW Angina pectoris BA40 Approved [110]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [111]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [112]
Zolmitriptan DM1IB4Q Migraine 8A80 Approved [168]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [168]
Etoricoxib DM6A4NW Rheumatoid arthritis FA20 Approved [168]
Capsaicin DMGMF6V Back pain ME84.Z Approved [169]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [170]
Stiripentol DMMSDOY Dravet syndrome 8A61.11 Approved [171]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [172]
Zileuton DMVRIC2 Allergic asthma CA23.0 Approved [173]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [174]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [175]
⏷ Show the Full List of 20 Drug(s)
Drug(s) Metabolized By UDP-glucuronosyltransferase 1A1 (UGT1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [113]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [114]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [115]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [116]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [117]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [118]
Metronidazole DMTIVEN Abscess Approved [119]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [120]
Ethanol DMDRQZU Chronic pain MG30 Approved [121]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [122]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [123]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [124]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [125]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [126]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [127]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [128]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [129]
Verapamil DMA7PEW Angina pectoris BA40 Approved [130]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [126]
Estrone DM5T6US Acne vulgaris ED80 Approved [131]
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [159]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [160]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [165]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [165]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [176]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [177]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [178]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [181]
⏷ Show the Full List of 20 Drug(s)
Drug(s) Metabolized By Cytochrome P450 2E1 (CYP2E1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Folic Acid DMEMBJC Colorectal carcinoma Approved [132]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [133]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [134]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [135]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [109]
Verapamil DMA7PEW Angina pectoris BA40 Approved [136]
Estrone DM5T6US Acne vulgaris ED80 Approved [137]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [138]
Ethanol DMDRQZU Chronic pain MG30 Approved [139]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [140]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Glutathione S-transferase pi (GSTP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [141]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [142]
Carboplatin DMG281S Adenocarcinoma 2D40 Approved [142]
Busulfan DMXYJ9C Chronic myelogenous leukaemia 2A20.0 Approved [143]
Chlorambucil DMRKE63 Chronic lymphocytic leukaemia 2A82.0 Approved [144]
Drug(s) Metabolized By Prostaglandin G/H synthase 1 (COX-1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [101]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Diazepam DM08E9O Alcohol withdrawal Approved [101]
Dapsone DM4LT8A Acne vulgaris ED80 Approved [101]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [101]
Nateglinide DMLK2QH Diabetic complication 5A2Y Approved [101]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [101]
Ketobemidone DMM3L6Z Pain MG30-MG3Z Approved [101]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [101]
Terbinafine DMI6HUW Fungal infection 1F29-1F2F Approved [101]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Glutathione S-transferase theta-1 (GSTT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [141]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [142]
Carboplatin DMG281S Adenocarcinoma 2D40 Approved [142]
Drug(s) Metabolized By Prostaglandin G/H synthase 2 (COX-2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dapsone DM4LT8A Acne vulgaris ED80 Approved [101]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [145]
Epanova DMHEAGL Hypertriglyceridemia 5C80.1 Approved [146]
Gamma-Homolinolenic acid DMSXKYG Malnutrition 5B50-5B71 Approved [145]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [145]
Omega-6-FA DMBWY8V N. A. N. A. Phase 3 [147]
Arachidonic Acid DMUOQZD Discovery agent N.A. Investigative [148]
alpha-linolenic acid DMY64HE Discovery agent N.A. Investigative [145]
Eicosadienoic acid DMVJK9W N. A. N. A. Investigative [145]
Icosapentum DMF1CM7 N. A. N. A. Investigative [145]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [149]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [150]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [151]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [152]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [153]
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [154]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [155]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [156]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [157]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [158]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutathione S-transferase P (GSTP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Busulfan DMXYJ9C Chronic myelogenous leukaemia 2A20.0 Approved [182]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [183]
Chlorambucil DMRKE63 Chronic lymphocytic leukaemia 2A82.0 Approved [184]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [185]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [186]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [187]
Selenium DM25CGV N. A. N. A. Approved [188]
Etretinate DM2CZFA Keratosis ED56 Approved [189]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [190]
Quercetin DM3NC4M Obesity 5B81 Approved [191]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [192]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [193]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [194]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [195]
Cepharanthine DM9Y5JB N. A. N. A. Approved [196]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [197]
Clozapine DMFC71L Schizophrenia 6A20 Approved [198]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [199]
Trifluoperazine DMKBYWI Anxiety Approved [200]
Olanzapine DMPFN6Y Bipolar depression Approved [198]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-binding cassette sub-family C member 3 (ABCC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [201]
Methotrexate DM2TEOL Anterior urethra cancer Approved [202]
Calcipotriol DM03CP7 Psoriasis EA90 Approved [203]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [186]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [204]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Prednisone DM2HG4X Acute asthma CA23 Approved [206]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [207]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [208]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [209]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-binding cassette sub-family C member 2 (ABCC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lopinavir DMITQS0 Human immunodeficiency virus infection 1C62 Approved [218]
Sulfinpyrazone DMEV954 Gout FA25 Approved [219]
Probenecid DMMFWOJ Acute gonococcal cervicitis Approved [220]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [221]
Methotrexate DM2TEOL Anterior urethra cancer Approved [211]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [222]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [209]
Epirubicin DMPDW6T Solid tumour/cancer 2A00-2F9Z Approved [215]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [201]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [223]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA topoisomerase 2-alpha (TOP2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [224]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [225]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [226]
Methotrexate DM2TEOL Anterior urethra cancer Approved [227]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [228]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [231]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [232]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [233]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [234]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [235]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [236]
Paclitaxel DMLB81S Breast carcinoma Approved [237]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [238]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [175]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [239]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [240]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [241]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [242]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [243]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [244]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [245]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [246]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [247]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [248]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [249]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [250]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [251]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [252]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [253]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [254]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [255]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [256]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [257]
Verapamil DMA7PEW Angina pectoris BA40 Approved [258]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [259]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [240]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [260]
Flucytosine DM13VTW Cryptococcal meningitis Approved [261]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-8 (CASP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [262]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [263]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [239]
Gefitinib DM15F0X Colon adenocarcinoma Approved [264]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [265]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [266]
Selenium DM25CGV N. A. N. A. Approved [188]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [267]
Methotrexate DM2TEOL Anterior urethra cancer Approved [268]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [269]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor protein p73 (TP73)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [270]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [271]
Etretinate DM2CZFA Keratosis ED56 Approved [272]
Quercetin DM3NC4M Obesity 5B81 Approved [273]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [274]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [275]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [276]
Menthol DMG2KW7 Back pain ME84.Z Approved [277]
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [272]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [278]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (CYP27B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcidiol DMN4CV5 Hypophosphatemia Approved [279]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [280]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [282]
Arsenic DMTL2Y1 N. A. N. A. Approved [283]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [284]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [285]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dihydropyrimidinase-related protein 4 (DPYSL4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [19]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [19]
Testosterone DM7HUNW Hot flushes GA30 Approved [286]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Clozapine DMFC71L Schizophrenia 6A20 Approved [287]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [288]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [183]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Copper chaperone for superoxide dismutase (CCS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [290]
Testosterone enanthate DMB6871 N. A. N. A. Approved [291]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Ethanol DMDRQZU Chronic pain MG30 Approved [293]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [294]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [183]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [223]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Urokinase-type plasminogen activator (PLAU)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [19]
Methotrexate DM2TEOL Anterior urethra cancer Approved [295]
Quercetin DM3NC4M Obesity 5B81 Approved [296]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [297]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [19]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [299]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [301]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [302]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [303]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [204]
Gefitinib DM15F0X Colon adenocarcinoma Approved [304]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [305]
Selenium DM25CGV N. A. N. A. Approved [306]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [307]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [308]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [309]
Methotrexate DM2TEOL Anterior urethra cancer Approved [268]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ubiquitin-like protein ISG15 (ISG15)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [310]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [311]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [310]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [19]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [312]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [313]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Testosterone enanthate DMB6871 N. A. N. A. Approved [291]
Tofacitinib DMBS370 Rheumatoid arthritis FA20 Approved [314]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Integrin alpha-IIb (ITGA2B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [315]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [19]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [305]
Asasantin DMCZIHT Cerebrovascular ischaemia 8B1Z Approved [315]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [316]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [183]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [317]
Abciximab DMJO6GV Acute disease Approved [175]
Tirofiban DMQG17S Acute coronary syndrome BA41 Approved [175]
Eptifibatide DMQXTJS Acute cardiac ischemic events BA40.Z Approved [175]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ras-related protein R-Ras (RRAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [318]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [19]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [297]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [319]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [322]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [303]
Gefitinib DM15F0X Colon adenocarcinoma Approved [323]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [324]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [325]
Methotrexate DM2TEOL Anterior urethra cancer Approved [326]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [19]
Quercetin DM3NC4M Obesity 5B81 Approved [273]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [327]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [328]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Stomatin (STOM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [329]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [19]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [288]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [330]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [331]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cellular retinoic acid-binding protein 2 (CRABP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [332]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [19]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [333]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [334]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [275]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [335]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tyrosine-protein kinase receptor UFO (AXL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [188]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [19]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [336]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [19]
Plicamycin DM7C8YV Hypercalcaemia 5B91.0 Approved [337]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [338]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [338]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [338]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 14-3-3 protein sigma (SFN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [339]
Gefitinib DM15F0X Colon adenocarcinoma Approved [323]
Methotrexate DM2TEOL Anterior urethra cancer Approved [340]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [19]
Quercetin DM3NC4M Obesity 5B81 Approved [341]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [290]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [19]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [342]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [343]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Galectin-7 (LGALS7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [19]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [19]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Arsenic DMTL2Y1 N. A. N. A. Approved [344]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [345]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [298]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [346]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [347]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [348]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Rho GDP-dissociation inhibitor 2 (ARHGDIB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [268]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [19]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [311]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [19]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [349]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [319]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [350]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Epithelial membrane protein 1 (EMP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [19]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [351]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [19]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [351]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [334]
Testosterone DM7HUNW Hot flushes GA30 Approved [286]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Epithelial membrane protein 3 (EMP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [188]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [19]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [352]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [19]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [319]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [353]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein ripply3 (RIPPLY3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [19]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [19]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [356]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [357]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [183]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Kinesin-like protein KIF1A (KIF1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [19]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [359]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [360]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [361]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [298]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [362]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Filamin-C (FLNC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [271]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [19]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [19]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [353]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [363]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [364]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Immediate early response gene 5 protein (IER5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [19]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [19]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [356]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [365]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Keratin, type II cytoskeletal 80 (KRT80)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [19]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [19]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [313]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [275]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [356]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [366]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By All-trans-retinol 13,14-reductase (RETSAT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [19]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [288]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [183]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [363]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitochondria-eating protein (SPATA18)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [19]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [298]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [357]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [357]
Indomethacin DMSC4A7 Bursitis Approved [367]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 14 (TNFRSF14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [231]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [19]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [368]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [369]
Exemestane DM9HPW3 Hormonally-responsive breast cancer 2C60-2C65 Approved [370]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Folic Acid DMEMBJC Colorectal carcinoma Approved [371]
Menthol DMG2KW7 Back pain ME84.Z Approved [277]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [356]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Major histocompatibility complex class I-related gene protein (MR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [372]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [372]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [372]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [19]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [372]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [372]
Repaglinide DM5SXUV Diabetic complication 5A2Y Approved [372]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [374]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Roundabout homolog 3 (ROBO3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [297]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Folic Acid DMEMBJC Colorectal carcinoma Approved [375]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Arsenic DMTL2Y1 N. A. N. A. Approved [344]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [376]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [360]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [347]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Neuronal PAS domain-containing protein 1 (NPAS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [305]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [183]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [377]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [378]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [379]
acetaldehyde DMJFKG4 Discovery agent N.A. Investigative [380]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ankyrin repeat domain-containing protein 10 (ANKRD10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [381]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [382]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [383]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [282]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase PLK2 (PLK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [384]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [334]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [275]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [288]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [385]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [19]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [288]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [386]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
Urethane DM7NSI0 N. A. N. A. Phase 4 [387]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [388]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutaminase liver isoform, mitochondrial (GLS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [183]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [330]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [179]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [389]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [390]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [391]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Endothelial protein C receptor (PROCR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [340]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [19]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [19]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [288]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [357]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fatty acid desaturase 3 (FADS3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [188]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [19]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [383]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [183]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [223]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [179]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Catalase (CAT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [392]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [393]
Haloperidol DM96SE0 Delirium Approved [175]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [394]
Selenium DM25CGV N. A. N. A. Approved [395]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [396]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [397]
Methotrexate DM2TEOL Anterior urethra cancer Approved [268]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [398]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NADH-ubiquinone oxidoreductase chain 4 (ND4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [399]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [400]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [334]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [401]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Cholecalciferol DMGU74E Adult acute monocytic leukemia Approved [402]
Arsenic DMTL2Y1 N. A. N. A. Approved [403]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
Urethane DM7NSI0 N. A. N. A. Phase 4 [387]
CERC-801 DM3SZ7P N. A. N. A. Phase 2 [404]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nitric oxide synthase, inducible (NOS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
Indomethacin DMSC4A7 Bursitis Approved [405]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [406]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [407]
Methotrexate DM2TEOL Anterior urethra cancer Approved [318]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [408]
Quercetin DM3NC4M Obesity 5B81 Approved [409]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [410]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [411]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [412]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor A, mitochondrial (TFAM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [413]
Quercetin DM3NC4M Obesity 5B81 Approved [414]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [415]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Testosterone DM7HUNW Hot flushes GA30 Approved [286]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [416]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [390]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [417]
Zalcitabine DMH7MUV Human immunodeficiency virus infection 1C62 Approved [418]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [419]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By TP53-binding protein 1 (TP53BP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [420]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [421]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [422]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [423]
Arsenic DMTL2Y1 N. A. N. A. Approved [424]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [425]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [359]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peroxisome proliferator-activated receptor gamma coactivator 1-beta (PPARGC1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Quercetin DM3NC4M Obesity 5B81 Approved [426]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [386]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [205]
Arsenic DMTL2Y1 N. A. N. A. Approved [344]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [330]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [427]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [298]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [415]
Fructose DM43AN2 Vomiting MD90 Approved [428]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [429]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [430]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [319]
Ketotifen DM74XKS Allergic conjunctivitis 9A60.02 Approved [431]
Riboflavin DM8YMWE Acne vulgaris ED80 Approved [432]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [432]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Calsequestrin-2 (CASQ2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [275]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [433]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [434]
Arsenic DMTL2Y1 N. A. N. A. Approved [344]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [389]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [360]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [379]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Telethonin (TCAP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone enanthate DMB6871 N. A. N. A. Approved [291]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [183]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [389]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [389]
Urethane DM7NSI0 N. A. N. A. Phase 4 [387]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [347]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [379]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By LIM domain-binding protein 3 (LDB3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [286]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [435]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [435]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [435]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [390]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [360]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [436]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [379]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [437]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Creatine kinase M-type (CKM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [438]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [319]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [435]
Salbutamol DMN9CWF Acute asthma CA23 Approved [439]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [440]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [435]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [363]
Carbimazole DMULAI4 Hyperthyroidism 5A02 Approved [441]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [435]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutathione peroxidase 1 (GPX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [324]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [183]
Amlexanox DM0DQM5 Respiratory tract inflammation CA07 Approved [442]
Selenium DM25CGV N. A. N. A. Approved [443]
Methotrexate DM2TEOL Anterior urethra cancer Approved [444]
Quercetin DM3NC4M Obesity 5B81 Approved [445]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [410]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [311]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [446]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [447]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myosin light chain 3 (MYL3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [356]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [389]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [360]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [347]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [379]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [271]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By Keratin, type I cytoskeletal 19 (KRT19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [448]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [449]
Selenium DM25CGV N. A. N. A. Approved [188]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [351]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [351]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [450]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [313]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [353]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [338]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Calmodulin-1 (CALM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Selenium DM25CGV N. A. N. A. Approved [188]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [325]
Methotrexate DM2TEOL Anterior urethra cancer Approved [318]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [325]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [451]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MYL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [452]
Ethanol DMDRQZU Chronic pain MG30 Approved [453]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [454]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [389]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [389]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [347]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [379]
QUERCITRIN DM1DH96 Discovery agent N.A. Investigative [455]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Glycogen phosphorylase, muscle form (PYGM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Prednisone DM2HG4X Acute asthma CA23 Approved [456]
Haloperidol DM96SE0 Delirium Approved [287]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [435]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [435]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [183]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [435]
Urethane DM7NSI0 N. A. N. A. Phase 4 [387]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [378]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [379]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dystrophin (DMD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [271]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [457]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [297]
Thioguanine DM7NKEV Acute lymphocytic leukaemia 2B33.3 Approved [458]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [381]
Gentamicin DMKINJO Bacteremia 1A73 Approved [459]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [435]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [435]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myosin-7 (MYH7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Folic Acid DMEMBJC Colorectal carcinoma Approved [433]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [435]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [433]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [435]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [435]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [460]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [460]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Leukemia inhibitory factor (LIF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [257]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [461]
Methotrexate DM2TEOL Anterior urethra cancer Approved [318]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [462]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [463]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [334]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [275]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [338]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [389]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [186]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [392]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [464]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [465]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [466]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [467]
Quercetin DM3NC4M Obesity 5B81 Approved [468]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [469]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ankyrin-1 (ANK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Testosterone enanthate DMB6871 N. A. N. A. Approved [291]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [390]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [183]
Arsenic DMTL2Y1 N. A. N. A. Approved [344]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [389]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [470]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [390]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Desmin (DES)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [457]
Selenium DM25CGV N. A. N. A. Approved [188]
Methotrexate DM2TEOL Anterior urethra cancer Approved [471]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Artesunate DMR27C8 Infection of P. falciparum 1F40 Approved [472]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [473]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [474]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [389]
Zalcitabine DMH7MUV Human immunodeficiency virus infection 1C62 Approved [175]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [448]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [461]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [266]
Methotrexate DM2TEOL Anterior urethra cancer Approved [475]
Epinephrine DM3KJBC Acute asthma CA23 Approved [476]
Quercetin DM3NC4M Obesity 5B81 Approved [477]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [478]
Fructose DM43AN2 Vomiting MD90 Approved [479]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [448]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [480]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CCN family member 2 (CCN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [257]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [155]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [449]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [481]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [329]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [310]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [482]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [313]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [322]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sodium/calcium exchanger 1 (SLC8A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Arsenic DMTL2Y1 N. A. N. A. Approved [344]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [483]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [285]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [389]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [360]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [484]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [485]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [379]
Geldanamycin DMS7TC5 Kidney cancer 2C90.0 Discontinued in Phase 2 [450]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Thrombospondin-4 (THBS4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [349]
Testosterone enanthate DMB6871 N. A. N. A. Approved [291]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [390]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [350]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [357]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [357]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [389]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [390]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Gap junction alpha-5 protein (GJA5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [486]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [389]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [360]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [347]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [379]
Sulforaphane DMQY3L0 Skin disease EA00-EM0Z Investigative [487]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By Vasopressin V1a receptor (AVPR1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [488]
Vasopressin DMQ2FPC Diabetes insipidus 5A61.5 Approved [489]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [490]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [389]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [377]
Insulin DMB7CE0 Diabetic complication 5A2Y Approved [175]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [175]
Alprostadil DMWH7NQ Aorta coarctation Approved [175]
Dinoprost Tromethamine DMXQKSL Abortion JA00 Approved [175]
Bardoxolone methyl DMODA2X Mixed connective tissue disease 4A43.3 Phase 3 [491]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sodium/potassium-transporting ATPase subunit alpha-2 (ATP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [492]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [435]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [357]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [435]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By cAMP-dependent protein kinase catalytic subunit PRKX (PRKX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [286]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [435]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [493]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [435]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [183]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [454]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [494]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Stanniocalcin-1 (STC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [271]
Quercetin DM3NC4M Obesity 5B81 Approved [495]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [481]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [496]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [334]
Testosterone DM7HUNW Hot flushes GA30 Approved [286]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Ethanol DMDRQZU Chronic pain MG30 Approved [293]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myomesin-2 (MYOM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [271]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [435]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [435]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [435]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [497]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [379]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [498]
QUERCITRIN DM1DH96 Discovery agent N.A. Investigative [455]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [271]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Actin, alpha skeletal muscle (ACTA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [271]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [275]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Folic Acid DMEMBJC Colorectal carcinoma Approved [375]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Iroquois-class homeodomain protein IRX-4 (IRX4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [448]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [452]
Testosterone DM7HUNW Hot flushes GA30 Approved [286]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [499]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [435]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [500]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [435]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [494]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [435]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Arginase-2, mitochondrial (ARG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [257]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [501]
Selenium DM25CGV N. A. N. A. Approved [188]
Methotrexate DM2TEOL Anterior urethra cancer Approved [227]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [349]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [313]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [502]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome c oxidase subunit 6A2, mitochondrial (COX6A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [481]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [473]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [330]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [389]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [377]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [360]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [179]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Pro-neuregulin-1, membrane-bound isoform (NRG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [339]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [271]
Methotrexate DM2TEOL Anterior urethra cancer Approved [318]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [19]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [374]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity protein phosphatase 4 (DUSP4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [257]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [349]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [503]
Testosterone DM7HUNW Hot flushes GA30 Approved [286]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [275]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [381]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Krueppel-like factor 5 (KLF5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [325]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [305]
Testosterone DM7HUNW Hot flushes GA30 Approved [286]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [275]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Four and a half LIM domains protein 2 (FHL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [271]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [325]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [297]
Estrone DM5T6US Acne vulgaris ED80 Approved [504]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [450]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [334]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transmembrane glycoprotein NMB (GPNMB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [462]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [450]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [338]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [338]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [381]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [356]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Periostin (POSTN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [188]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [469]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [450]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Paclitaxel DMLB81S Breast carcinoma Approved [505]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [288]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [223]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [506]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By kinase isozyme 1, mitochondrial (PDK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [338]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [229]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [338]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [381]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [507]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [473]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By kinase isozyme 4, mitochondrial (PDK4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [508]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [509]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [510]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [511]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [338]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [338]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [338]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Testosterone enanthate DMB6871 N. A. N. A. Approved [291]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By PDZ and LIM domain protein 3 (PDLIM3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [357]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [357]
Arsenic DMTL2Y1 N. A. N. A. Approved [344]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [285]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [389]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [376]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [360]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nebulin-related-anchoring protein (NRAP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [334]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [435]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [435]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [435]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [378]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [379]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By Sodium channel subunit beta-4 (SCN4B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [329]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [450]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [389]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [298]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [298]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [347]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [379]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [421]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Actin-binding Rho-activating protein (ABRA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Folic Acid DMEMBJC Colorectal carcinoma Approved [375]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [360]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [378]
Drug(s) Affected By Transient receptor potential cation channel subfamily V member 1 (TRPV1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [512]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [513]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [514]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Menthol DMG2KW7 Back pain ME84.Z Approved [515]
Capsaicin DMGMF6V Back pain ME84.Z Approved [516]
Lidocaine DML4ZOT Anaesthesia 9A78.6 Approved [517]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ryanodine receptor 2 (RYR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [518]
Isoproterenol DMK7MEY Atrioventricular block Approved [519]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [435]
Atenolol DMNKG1Z Angina pectoris BA40 Approved [518]
Metoprolol DMOJ0V6 Acute coronary syndrome BA41 Approved [518]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [435]
Arsenic DMTL2Y1 N. A. N. A. Approved [344]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [435]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [359]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Small conductance calcium-activated potassium channel protein 2 (KCNN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [450]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Tubocurarine DMBZIVP Anaesthesia 9A78.6 Approved [520]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [381]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [389]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [376]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [521]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Regulator of cell cycle RGCC (RGCC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [481]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [450]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [522]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Ampicillin DMHWE7P Acute epiglottitis Approved [229]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [523]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [366]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myotilin (MYOT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [378]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [379]
Torcetrapib DMDHYM7 Hyperlipidaemia 5C80 Discontinued in Phase 2 [524]
Drug(s) Affected By Protein ATP1B4 (ATP1B4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [271]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [389]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [347]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [379]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [271]
Drug(s) Affected By Junctional adhesion molecule A (F11R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [271]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Selenium DM25CGV N. A. N. A. Approved [188]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [183]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [525]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Succinate dehydrogenase assembly factor 1, mitochondrial (SDHAF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [22]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [22]
Adenine DMZLHKJ Malnutrition 5B50-5B71 Approved [22]
Urethane DM7NSI0 N. A. N. A. Phase 4 [387]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [347]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [288]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [526]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Agrin (AGRN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [188]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [338]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [338]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [338]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [338]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [527]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [528]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [288]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By E3 ubiquitin-protein ligase TRIM38 (TRIM38)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [188]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [481]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [529]
Testosterone DM7HUNW Hot flushes GA30 Approved [286]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [499]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Torsin-1A (TOR1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [488]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [22]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [22]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [22]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Etoposide-induced protein 2.4 homolog (EI24)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [349]
Amifostine DM5FL14 Mucositis CA00 Approved [530]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Menthol DMG2KW7 Back pain ME84.Z Approved [277]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [531]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [183]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [22]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [532]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [239]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [533]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [534]
Selenium DM25CGV N. A. N. A. Approved [535]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [536]
Methotrexate DM2TEOL Anterior urethra cancer Approved [295]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [536]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tax1-binding protein 3 (TAX1BP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [188]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [531]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [183]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [537]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [538]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [359]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [539]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [540]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [541]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [297]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [539]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [542]
Testosterone DM7HUNW Hot flushes GA30 Approved [286]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Ibrutinib DMHZCPO Mantle cell lymphoma 2A85.5 Approved [543]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [544]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proepiregulin (EREG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [339]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [156]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [156]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [156]
Methotrexate DM2TEOL Anterior urethra cancer Approved [318]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [545]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [156]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor EC (TFEC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [412]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [22]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [22]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [22]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [434]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [271]
acetaldehyde DMJFKG4 Discovery agent N.A. Investigative [380]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [546]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [208]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [547]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [548]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [334]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [549]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [550]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein phosphatase 1D (PPM1D)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [364]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [461]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [266]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [297]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [551]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [552]
Testosterone DM7HUNW Hot flushes GA30 Approved [286]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [338]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [553]
Gefitinib DM15F0X Colon adenocarcinoma Approved [554]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [555]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [266]
Etretinate DM2CZFA Keratosis ED56 Approved [272]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [325]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [556]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [557]
Quercetin DM3NC4M Obesity 5B81 Approved [558]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [559]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CASP8 and FADD-like apoptosis regulator (CFLAR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [448]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [560]
Methotrexate DM2TEOL Anterior urethra cancer Approved [561]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [562]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [563]
Quercetin DM3NC4M Obesity 5B81 Approved [564]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [559]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [565]
Ethacrynic acid DM60QMR Edema MG29 Approved [566]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By E3 ubiquitin-protein ligase RNF113A (RNF113A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Quercetin DM3NC4M Obesity 5B81 Approved [420]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [334]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [22]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [22]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [22]
Adenine DMZLHKJ Malnutrition 5B50-5B71 Approved [22]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Receptor-interacting serine/threonine-protein kinase 2 (RIPK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [310]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [297]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [310]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [499]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Menthol DMG2KW7 Back pain ME84.Z Approved [277]
Capsaicin DMGMF6V Back pain ME84.Z Approved [567]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Krueppel-like factor 4 (KLF4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [322]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [462]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [482]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [568]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [322]
Testosterone DM7HUNW Hot flushes GA30 Approved [569]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [499]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [276]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Forkhead box protein O3 (FOXO3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [570]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [571]
Quercetin DM3NC4M Obesity 5B81 Approved [273]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [329]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [572]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [573]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [574]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [374]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytoplasmic protein NCK2 (NCK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [275]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [390]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [531]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [183]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [330]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
Urethane DM7NSI0 N. A. N. A. Phase 4 [387]
Camptothecin DM6CHNJ Solid tumour/cancer 2A00-2F9Z Phase 3 [531]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein regulator of cytokinesis 1 (PRC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [155]
Methotrexate DM2TEOL Anterior urethra cancer Approved [531]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [319]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [338]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [338]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [339]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [553]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [501]
Methotrexate DM2TEOL Anterior urethra cancer Approved [227]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [297]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By HMG box-containing protein 1 (HBP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [297]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [573]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [319]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [339]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [553]
Methotrexate DM2TEOL Anterior urethra cancer Approved [227]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [575]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cell division control protein 45 homolog (CDC45)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [339]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [336]
Quercetin DM3NC4M Obesity 5B81 Approved [564]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [352]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [576]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [381]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [577]
Vidarabine DM0N85H Hepatosplenic T-cell lymphoma Approved [577]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [578]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [579]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [580]
Etidronic acid DM1XHYJ Bone Paget disease Approved [577]
Tiaprofenic acid DM23D7J Osteoarthritis FA00-FA05 Approved [577]
Bromperidol DM24XYQ Schizophrenia 6A20 Approved [577]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [581]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [582]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Kinesin-like protein KIF20A (KIF20A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [364]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Methotrexate DM2TEOL Anterior urethra cancer Approved [227]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myelin protein zero-like protein 1 (MPZL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [295]
Quercetin DM3NC4M Obesity 5B81 Approved [420]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [382]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [22]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [22]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [22]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase Chk2 (CHEK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [583]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [339]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [584]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [585]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [374]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [586]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Capsaicin DMGMF6V Back pain ME84.Z Approved [567]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aldehyde dehydrogenase 1A1 (ALDH1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [587]
Methotrexate DM2TEOL Anterior urethra cancer Approved [227]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [588]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [589]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [590]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [591]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [592]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Epidermal growth factor receptor (EGFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [593]
Gefitinib DM15F0X Colon adenocarcinoma Approved [594]
Erlotinib DMCMBHA Adrenal gland neoplasm Approved [595]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [596]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [597]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [598]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [303]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [457]
Selenium DM25CGV N. A. N. A. Approved [599]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [600]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein c-Fos (FOS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [319]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [601]
Verapamil DMA7PEW Angina pectoris BA40 Approved [602]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [303]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [602]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [204]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [187]
Methotrexate DM2TEOL Anterior urethra cancer Approved [603]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [604]
Quercetin DM3NC4M Obesity 5B81 Approved [605]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protransforming growth factor alpha (TGFA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [155]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [155]
Methotrexate DM2TEOL Anterior urethra cancer Approved [295]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [606]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [607]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [499]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By HLA class I histocompatibility antigen, B alpha chain (HLA-B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [608]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [609]
Allopurinol DMLPAOB Gout FA25 Approved [610]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [454]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [611]
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [372]
Abacavir DMMN36E Human immunodeficiency virus infection 1C62 Approved [612]
Flucloxacillin DMNUWST Bacterial infection 1A00-1C4Z Approved [613]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [614]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transferrin receptor protein 1 (TFRC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [225]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [615]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [616]
Quercetin DM3NC4M Obesity 5B81 Approved [617]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [469]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [352]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [349]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [573]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [618]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [619]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ferritin light chain (FTL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [186]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [461]
Selenium DM25CGV N. A. N. A. Approved [188]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [620]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [621]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [319]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [622]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Ethanol DMDRQZU Chronic pain MG30 Approved [623]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Metallothionein-2 (MT2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [624]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [257]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [461]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [625]
Quercetin DM3NC4M Obesity 5B81 Approved [626]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [410]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [573]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [374]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [627]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [338]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interstitial collagenase (MMP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [339]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [628]
Etretinate DM2CZFA Keratosis ED56 Approved [629]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [630]
Methotrexate DM2TEOL Anterior urethra cancer Approved [318]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [631]
Quercetin DM3NC4M Obesity 5B81 Approved [632]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [633]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [634]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [305]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [635]
Selenium DM25CGV N. A. N. A. Approved [636]
Methotrexate DM2TEOL Anterior urethra cancer Approved [310]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [467]
Epinephrine DM3KJBC Acute asthma CA23 Approved [637]
Quercetin DM3NC4M Obesity 5B81 Approved [638]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [469]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [290]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [639]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [462]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By HLA class I histocompatibility antigen, A alpha chain (HLA-A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [640]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [609]
Allopurinol DMLPAOB Gout FA25 Approved [641]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [642]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [614]
Ticlopidine DMO946V Acute coronary syndrome BA41 Approved [643]
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [614]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [372]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [372]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Trastuzumab DMZQOUX Breast cancer 2C60-2C65 Approved [175]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [644]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [645]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [204]
Gefitinib DM15F0X Colon adenocarcinoma Approved [646]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [187]
Selenium DM25CGV N. A. N. A. Approved [188]
Methotrexate DM2TEOL Anterior urethra cancer Approved [318]
Quercetin DM3NC4M Obesity 5B81 Approved [647]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [648]
Methotrexate DM2TEOL Anterior urethra cancer Approved [268]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [649]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [650]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [246]
Paclitaxel DMLB81S Breast carcinoma Approved [651]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [652]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [252]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [653]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [654]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [655]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [656]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [657]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [658]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [659]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [410]
Ethacrynic acid DM60QMR Edema MG29 Approved [660]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [661]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [662]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [663]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Retinoblastoma-associated protein (RB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [664]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [665]
Gefitinib DM15F0X Colon adenocarcinoma Approved [666]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [667]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [187]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [308]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [668]
Methotrexate DM2TEOL Anterior urethra cancer Approved [669]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [670]
Quercetin DM3NC4M Obesity 5B81 Approved [647]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor Sp1 (SP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fructose DM43AN2 Vomiting MD90 Approved [175]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [671]
Quercetin DM3NC4M Obesity 5B81 Approved [672]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [673]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [674]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [297]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [675]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [671]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [676]
Plicamycin DM7C8YV Hypercalcaemia 5B91.0 Approved [677]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By High mobility group protein B1 (HMGB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [364]
Gefitinib DM15F0X Colon adenocarcinoma Approved [678]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [679]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [496]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [680]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Annexin A4 (ANXA4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Quercetin DM3NC4M Obesity 5B81 Approved [681]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [488]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [682]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [350]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [288]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [257]
Gefitinib DM15F0X Colon adenocarcinoma Approved [683]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [684]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [266]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [685]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [686]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [685]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [687]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [688]
Methotrexate DM2TEOL Anterior urethra cancer Approved [689]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [690]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [691]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [692]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [693]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [694]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [695]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [156]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [392]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [696]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [156]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C motif chemokine 3 (CCL3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [697]
Methotrexate DM2TEOL Anterior urethra cancer Approved [268]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [410]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [411]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [311]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [576]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [698]
Betamethasone DMAHJEF Acute adrenal insufficiency Approved [699]
Emetine DMCT2YF Hepatitis virus infection 1E50-1E51 Approved [699]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [697]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Androgen receptor (AR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [700]
Nilutamide DMFN07X Prostate cancer 2C82.0 Approved [700]
Hydroxyflutamide DMGIZF5 Prostate cancer 2C82.0 Approved [700]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [701]
Bicalutamide DMZMSPF Prostate cancer 2C82.0 Approved [702]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [703]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [704]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [705]
Selenium DM25CGV N. A. N. A. Approved [706]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [707]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cholesteryl ester transfer protein (CETP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [708]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [709]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [710]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [711]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Teniposide DMLW57T Acute lymphoblastic leukaemia 2A85 Approved [709]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [712]
Bezafibrate DMZDCS0 Hypercholesterolaemia 5C80.0 Approved [713]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [347]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [381]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [469]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [329]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [349]
Testosterone DM7HUNW Hot flushes GA30 Approved [286]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [469]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [353]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Translationally-controlled tumor protein (TPT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [714]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [311]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [715]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [716]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [717]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [528]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [718]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [427]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tissue factor (F3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [719]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [720]
Methotrexate DM2TEOL Anterior urethra cancer Approved [721]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [722]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [723]
Quercetin DM3NC4M Obesity 5B81 Approved [724]
Fructose DM43AN2 Vomiting MD90 Approved [479]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [725]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [720]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [589]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By HLA class I histocompatibility antigen, alpha chain E (HLA-E)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [372]
Clindamycin DM15HL8 Acne vulgaris ED80 Approved [372]
Selenium DM25CGV N. A. N. A. Approved [188]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [372]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [372]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [231]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [349]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [576]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [372]
Testosterone DM7HUNW Hot flushes GA30 Approved [286]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [339]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [726]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [225]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Selenium DM25CGV N. A. N. A. Approved [306]
Etretinate DM2CZFA Keratosis ED56 Approved [272]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [686]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [727]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [325]
Methotrexate DM2TEOL Anterior urethra cancer Approved [227]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein C-ets-1 (ETS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [728]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [325]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [319]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [729]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [730]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [356]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Amphiregulin (AREG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [257]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [731]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [461]
Methotrexate DM2TEOL Anterior urethra cancer Approved [295]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [600]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [545]
Estrone DM5T6US Acne vulgaris ED80 Approved [504]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [368]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [334]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [732]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone H2AX (H2AX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [733]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [734]
Selenium DM25CGV N. A. N. A. Approved [188]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [735]
Etretinate DM2CZFA Keratosis ED56 Approved [736]
Methotrexate DM2TEOL Anterior urethra cancer Approved [737]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [738]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [739]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [228]
Quercetin DM3NC4M Obesity 5B81 Approved [740]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Syndecan-1 (SDC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [290]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [297]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [576]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [353]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [488]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [356]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [741]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-A2 (CCNA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [644]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [726]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [204]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [461]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [742]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [668]
Methotrexate DM2TEOL Anterior urethra cancer Approved [227]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [336]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [743]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Receptor tyrosine-protein kinase erbB-3 (ERBB3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [155]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [744]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [353]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [488]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [435]
Chloroquine DMSI5CB Malaria 1F40-1F45 Approved [745]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By rRNA 2'-O-methyltransferase fibrillarin (FBL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [746]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [334]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [746]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [746]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [747]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NADPH:adrenodoxin oxidoreductase, mitochondrial (FDXR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [461]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [381]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [531]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [748]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [461]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Brain-derived neurotrophic factor (BDNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Haloperidol DM96SE0 Delirium Approved [749]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [155]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [750]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Bupivacaine DM4PRFC Anaesthesia 9A78.6 Approved [751]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [752]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [334]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [499]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [275]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [290]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [753]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [349]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [401]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [754]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [755]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [260]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [756]
Gefitinib DM15F0X Colon adenocarcinoma Approved [594]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [667]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [757]
Selenium DM25CGV N. A. N. A. Approved [188]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [307]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [758]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [339]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [726]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [759]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [760]
Selenium DM25CGV N. A. N. A. Approved [306]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [686]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [761]
Methotrexate DM2TEOL Anterior urethra cancer Approved [561]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [762]
Quercetin DM3NC4M Obesity 5B81 Approved [647]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fructose DM43AN2 Vomiting MD90 Approved [175]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [251]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [239]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [695]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [635]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [539]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [763]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [208]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [764]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [238]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [235]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [765]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [240]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [241]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [242]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [766]
Gefitinib DM15F0X Colon adenocarcinoma Approved [767]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [768]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [769]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tripeptidyl-peptidase 2 (TPP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [286]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [770]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [223]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [770]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [771]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [772]
Torcetrapib DMDHYM7 Hyperlipidaemia 5C80 Discontinued in Phase 2 [524]
Geldanamycin DMS7TC5 Kidney cancer 2C90.0 Discontinued in Phase 2 [450]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [437]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By M-phase inducer phosphatase 1 (CDC25A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [339]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [187]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Methotrexate DM2TEOL Anterior urethra cancer Approved [669]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [773]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [774]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [586]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [775]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By M-phase inducer phosphatase 3 (CDC25C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [339]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [187]
Methotrexate DM2TEOL Anterior urethra cancer Approved [318]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [573]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [776]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [777]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity protein kinase TTK (TTK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [339]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [553]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA replication licensing factor MCM7 (MCM7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [339]
Selenium DM25CGV N. A. N. A. Approved [188]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [743]
Quercetin DM3NC4M Obesity 5B81 Approved [564]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [462]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [450]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Replication factor C subunit 1 (RFC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Quercetin DM3NC4M Obesity 5B81 Approved [420]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [275]
Ethanol DMDRQZU Chronic pain MG30 Approved [293]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [22]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [22]
Arsenic DMTL2Y1 N. A. N. A. Approved [344]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [223]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 3 (LTBR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [188]
Methotrexate DM2TEOL Anterior urethra cancer Approved [318]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [469]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Menthol DMG2KW7 Back pain ME84.Z Approved [277]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [778]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [779]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [780]
Diphenylpyraline DMW4X37 Allergic rhinitis CA08.0 Approved [781]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [359]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Breast cancer type 1 susceptibility protein (BRCA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [257]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [756]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [782]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [783]
Methotrexate DM2TEOL Anterior urethra cancer Approved [318]
Quercetin DM3NC4M Obesity 5B81 Approved [273]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [784]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [231]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [319]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [785]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [601]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [225]
Gefitinib DM15F0X Colon adenocarcinoma Approved [554]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [667]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [461]
Etretinate DM2CZFA Keratosis ED56 Approved [272]
Prednisone DM2HG4X Acute asthma CA23 Approved [786]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [686]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor ETV6 (ETV6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [787]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [748]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [223]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [359]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [788]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [788]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [789]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [362]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor ligand superfamily member 9 (TNFSF9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Methotrexate DM2TEOL Anterior urethra cancer Approved [268]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [19]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [369]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [334]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [338]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [790]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [546]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [791]
Gefitinib DM15F0X Colon adenocarcinoma Approved [792]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [793]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [307]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [794]
Quercetin DM3NC4M Obesity 5B81 Approved [795]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [590]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [796]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-2 (CASP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [259]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [797]
Methotrexate DM2TEOL Anterior urethra cancer Approved [295]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [798]
Quercetin DM3NC4M Obesity 5B81 Approved [799]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [369]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [800]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [334]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [801]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RNA-binding protein 34 (RBM34)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [390]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [22]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [278]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [22]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [278]
Adenine DMZLHKJ Malnutrition 5B50-5B71 Approved [22]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [347]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA repair protein RAD52 homolog (RAD52)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [275]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [514]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [347]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [802]
Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [665]
Gefitinib DM15F0X Colon adenocarcinoma Approved [594]
Prednisone DM2HG4X Acute asthma CA23 Approved [786]
Methotrexate DM2TEOL Anterior urethra cancer Approved [803]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [804]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [596]
Quercetin DM3NC4M Obesity 5B81 Approved [805]
Fluoxetine DM3PD2C Bipolar depression Approved [806]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [807]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [808]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [188]
Methotrexate DM2TEOL Anterior urethra cancer Approved [295]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [290]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [590]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [809]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [271]
Gefitinib DM15F0X Colon adenocarcinoma Approved [264]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [810]
Epinephrine DM3KJBC Acute asthma CA23 Approved [476]
Quercetin DM3NC4M Obesity 5B81 Approved [811]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [410]
Fructose DM43AN2 Vomiting MD90 Approved [479]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [812]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [813]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [565]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Stromal cell-derived factor 1 (CXCL12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [448]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [504]
Methotrexate DM2TEOL Anterior urethra cancer Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [814]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [349]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Estrone DM5T6US Acne vulgaris ED80 Approved [504]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [815]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [275]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [816]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Iron-responsive element-binding protein 2 (IREB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [381]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [383]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [817]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [223]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [818]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [379]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [420]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [271]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear receptor-interacting protein 1 (NRIP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [155]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [462]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [499]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Clorgyline DMCEUJD Parkinson disease 8A00.0 Approved [819]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [527]
Teniposide DMLW57T Acute lymphoblastic leukaemia 2A85 Approved [709]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fatty acid synthase (FASN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [820]
Selenium DM25CGV N. A. N. A. Approved [188]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [821]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [822]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [823]
Quercetin DM3NC4M Obesity 5B81 Approved [495]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [290]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [606]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [351]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [824]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Centromere protein F (CENPF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Methotrexate DM2TEOL Anterior urethra cancer Approved [227]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [825]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CCAAT/enhancer-binding protein alpha (CEBPA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [501]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [606]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [826]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [827]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [828]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [334]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Efavirenz DMC0GSJ Human immunodeficiency virus infection 1C62 Approved [828]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [401]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA replication licensing factor MCM2 (MCM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [257]
Quercetin DM3NC4M Obesity 5B81 Approved [564]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [462]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [369]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [829]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By LIM/homeobox protein Lhx2 (LHX2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [22]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [22]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [357]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [22]
Adenine DMZLHKJ Malnutrition 5B50-5B71 Approved [22]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase Nek2 (NEK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [553]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [457]
Selenium DM25CGV N. A. N. A. Approved [188]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA mismatch repair protein Msh6 (MSH6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [339]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [231]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [381]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Death-associated protein kinase 1 (DAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [187]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [297]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [499]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [514]
Menthol DMG2KW7 Back pain ME84.Z Approved [277]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [779]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 12 (MAPK12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [830]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [290]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [831]
Sorbitol DMAN0DE Constipation DD91.1 Approved [832]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [275]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [833]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [298]
Amsacrine DMZKYIV Acute lymphoblastic leukaemia 2A85 Approved [834]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [835]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RecQ-like DNA helicase BLM (BLM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [339]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ataxin-1 (ATXN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [271]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [836]
Selenium DM25CGV N. A. N. A. Approved [188]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Methotrexate DM2TEOL Anterior urethra cancer Approved [295]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [837]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [338]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [338]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [338]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Oxysterols receptor LXR-beta (NR1H2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [710]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [838]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Gemfibrozil DMD8Q3J Hyperlipidaemia 5C80 Approved [839]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [839]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [840]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [839]
Arsenic DMTL2Y1 N. A. N. A. Approved [841]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-7 (CASP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [842]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [303]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [843]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [844]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [845]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [845]
Methotrexate DM2TEOL Anterior urethra cancer Approved [318]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [269]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [846]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [228]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [801]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [847]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [257]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [259]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [848]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [406]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [266]
Meloxicam DM2AR7L Arthritis FA20 Approved [849]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [267]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [850]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By BH3-interacting domain death agonist (BID)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [239]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [266]
Selenium DM25CGV N. A. N. A. Approved [535]
Quercetin DM3NC4M Obesity 5B81 Approved [564]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [290]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [297]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [851]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [852]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [853]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Triosephosphate isomerase (TPI1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [188]
Etretinate DM2CZFA Keratosis ED56 Approved [189]
Methotrexate DM2TEOL Anterior urethra cancer Approved [854]
Quercetin DM3NC4M Obesity 5B81 Approved [681]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [297]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [717]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [855]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [856]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Small ribosomal subunit protein eS6 (RPS6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [857]
Methotrexate DM2TEOL Anterior urethra cancer Approved [295]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [858]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [859]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [860]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [861]
Testosterone DM7HUNW Hot flushes GA30 Approved [862]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [863]
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [864]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA-dependent protein kinase catalytic subunit (PRKDC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [364]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [457]
Quercetin DM3NC4M Obesity 5B81 Approved [477]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [231]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [573]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [865]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [334]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [866]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [381]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein BTG2 (BTG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [461]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [231]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [867]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [868]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [368]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [319]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [552]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [451]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hepcidin (HAMP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [501]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [869]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [870]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [275]
Cantharidin DMBP5N3 Molluscum contagiosum infection 1E76 Approved [871]
Papaverine DMCA9QP Brain ischaemia 8B1Z Approved [871]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Ethanol DMDRQZU Chronic pain MG30 Approved [872]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome c (CYCS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [239]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [873]
Gefitinib DM15F0X Colon adenocarcinoma Approved [683]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [848]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [874]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [844]
Methotrexate DM2TEOL Anterior urethra cancer Approved [268]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [415]
Pefloxacin DM49IGF Gonococcal urethritis 1A70.0Y Approved [875]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By E3 ubiquitin-protein ligase Mdm2 (MDM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [239]
Flucytosine DM13VTW Cryptococcal meningitis Approved [261]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [261]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [876]
Methotrexate DM2TEOL Anterior urethra cancer Approved [318]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [877]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [649]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [573]
Amifostine DM5FL14 Mucositis CA00 Approved [530]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Runt-related transcription factor 1 (RUNX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [271]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [231]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [499]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [338]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [338]
Cotinine DMCEZ1B Insecticide N.A. Approved [878]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myelin transcription factor 1 (MYT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [879]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [880]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [359]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [470]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [881]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [882]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [880]
Octanal DMTN0OK N. A. N. A. Investigative [883]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By POU domain, class 5, transcription factor 1 (POU5F1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [587]
Quercetin DM3NC4M Obesity 5B81 Approved [884]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [885]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [482]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [463]
Testosterone DM7HUNW Hot flushes GA30 Approved [886]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [550]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [887]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA topoisomerase 2-beta (TOP2B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [224]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [364]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [231]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Menthol DMG2KW7 Back pain ME84.Z Approved [277]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [205]
Arsenic DMTL2Y1 N. A. N. A. Approved [888]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [363]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone-lysine N-methyltransferase 2A (KMT2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [889]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [890]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [334]
Testosterone enanthate DMB6871 N. A. N. A. Approved [291]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Ethanol DMDRQZU Chronic pain MG30 Approved [891]
Clozapine DMFC71L Schizophrenia 6A20 Approved [892]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [386]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [454]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Antigen peptide transporter 1 (TAP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Selenium DM25CGV N. A. N. A. Approved [188]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [19]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [231]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [19]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [576]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [381]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CCAAT/enhancer-binding protein zeta (CEBPZ)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [352]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [319]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [531]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [285]
Camptothecin DM6CHNJ Solid tumour/cancer 2A00-2F9Z Phase 3 [531]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [298]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [253]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [251]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [257]
Verapamil DMA7PEW Angina pectoris BA40 Approved [258]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [448]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [848]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [667]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [187]
Meloxicam DM2AR7L Arthritis FA20 Approved [893]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [686]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [240]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [448]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [894]
Methotrexate DM2TEOL Anterior urethra cancer Approved [561]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [895]
Quercetin DM3NC4M Obesity 5B81 Approved [477]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [411]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [448]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [896]
Ethacrynic acid DM60QMR Edema MG29 Approved [566]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Forkhead box protein O1 (FOXO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [897]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [898]
Quercetin DM3NC4M Obesity 5B81 Approved [420]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [899]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [353]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Chromatin assembly factor 1 subunit A (CHAF1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Quercetin DM3NC4M Obesity 5B81 Approved [420]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [22]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [350]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Oxysterols receptor LXR-alpha (NR1H3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [352]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [401]
Gemfibrozil DMD8Q3J Hyperlipidaemia 5C80 Approved [839]
Ethanol DMDRQZU Chronic pain MG30 Approved [900]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [839]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [901]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [840]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [902]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine-protein kinase ATM (ATM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [903]
Paromomycin DM1AGXN Amoebiasis 1A36 Approved [904]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [782]
Etretinate DM2CZFA Keratosis ED56 Approved [272]
Quercetin DM3NC4M Obesity 5B81 Approved [477]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [297]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [572]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [573]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [412]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [274]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA topoisomerase 3-alpha (TOP3A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Testosterone DM7HUNW Hot flushes GA30 Approved [286]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [275]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [22]
Adenine DMZLHKJ Malnutrition 5B50-5B71 Approved [22]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [347]
Torcetrapib DMDHYM7 Hyperlipidaemia 5C80 Discontinued in Phase 2 [524]
Lithium chloride DMHYLQ2 Discovery agent N.A. Investigative [905]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Baculoviral IAP repeat-containing protein 3 (BIRC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [906]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [251]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [271]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [266]
Methotrexate DM2TEOL Anterior urethra cancer Approved [318]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [290]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [297]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [480]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [274]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [907]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Baculoviral IAP repeat-containing protein 2 (BIRC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [906]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [251]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [563]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [908]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [909]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [482]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [910]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [907]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [911]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [912]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [322]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [501]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [266]
Methotrexate DM2TEOL Anterior urethra cancer Approved [737]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [913]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [914]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [411]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [915]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [573]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein BTG3 (BTG3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [368]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [22]
Paclitaxel DMLB81S Breast carcinoma Approved [916]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [22]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [917]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [386]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone RNA hairpin-binding protein (SLBP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [271]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [457]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Testosterone DM7HUNW Hot flushes GA30 Approved [286]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [22]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [365]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [22]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [22]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hypermethylated in cancer 1 protein (HIC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [311]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [334]
Testosterone DM7HUNW Hot flushes GA30 Approved [286]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [381]
Folic Acid DMEMBJC Colorectal carcinoma Approved [918]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [919]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [920]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
Urethane DM7NSI0 N. A. N. A. Phase 4 [387]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA replication licensing factor MCM6 (MCM6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [339]
Methotrexate DM2TEOL Anterior urethra cancer Approved [227]
Quercetin DM3NC4M Obesity 5B81 Approved [564]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [312]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [627]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Receptor tyrosine-protein kinase erbB-4 (ERBB4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [297]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [921]
Testosterone DM7HUNW Hot flushes GA30 Approved [286]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [922]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [298]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [493]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [787]
Arsenic DMTL2Y1 N. A. N. A. Approved [344]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [923]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neutral amino acid transporter B(0) (SLC1A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [338]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [338]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [338]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [22]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [338]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [924]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mothers against decapentaplegic homolog 2 (SMAD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [925]
Quercetin DM3NC4M Obesity 5B81 Approved [926]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [231]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [927]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [496]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [928]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [928]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-G2 (CCNG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [504]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Fluoxetine DM3PD2C Bipolar depression Approved [480]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Estrone DM5T6US Acne vulgaris ED80 Approved [504]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [319]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [499]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [338]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [338]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase inhibitor 3 (CDKN3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [339]
Methotrexate DM2TEOL Anterior urethra cancer Approved [227]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [929]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [229]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Quinone oxidoreductase PIG3 (TP53I3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [266]
Methotrexate DM2TEOL Anterior urethra cancer Approved [318]
Quercetin DM3NC4M Obesity 5B81 Approved [341]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [930]
Amifostine DM5FL14 Mucositis CA00 Approved [530]
Testosterone DM7HUNW Hot flushes GA30 Approved [286]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [931]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [338]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [338]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [338]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ribosomal protein eS27-like (RPS27L)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [188]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [334]
Testosterone DM7HUNW Hot flushes GA30 Approved [286]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [338]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [932]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [338]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [933]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [381]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein MCM10 homolog (MCM10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [339]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [462]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [502]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [390]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [934]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By EPM2A-interacting protein 1 (EPM2AIP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [531]
Arsenic DMTL2Y1 N. A. N. A. Approved [344]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [223]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [935]
Urethane DM7NSI0 N. A. N. A. Phase 4 [387]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [318]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [936]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [936]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [334]
Testosterone DM7HUNW Hot flushes GA30 Approved [286]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [338]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [338]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [932]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Partner and localizer of BRCA2 (PALB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [390]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [22]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [22]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [454]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
Adenine DMZLHKJ Malnutrition 5B50-5B71 Approved [22]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Jouberin (AHI1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [937]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Omacetaxine mepesuccinate DMPU2WX Adult acute monocytic leukemia Approved [937]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [183]
Arsenic DMTL2Y1 N. A. N. A. Approved [344]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [937]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [298]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Leucine-rich repeat-containing protein 47 (LRRC47)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [329]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [22]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [22]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [22]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
Adenine DMZLHKJ Malnutrition 5B50-5B71 Approved [22]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [188]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RelA-associated inhibitor (PPP1R13L)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [297]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Arsenic DMTL2Y1 N. A. N. A. Approved [344]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA repair and recombination protein RAD54-like (RAD54L)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [339]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [938]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Arsenic DMTL2Y1 N. A. N. A. Approved [344]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [363]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome c oxidase assembly factor 7 (COA7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [22]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [22]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [22]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [330]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitochondrial potassium channel (CCDC51)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [22]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [22]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [22]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [330]
Adenine DMZLHKJ Malnutrition 5B50-5B71 Approved [22]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [179]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Integrator complex subunit 15 (INTS15)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [188]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [22]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [22]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [22]
Adenine DMZLHKJ Malnutrition 5B50-5B71 Approved [22]
Urethane DM7NSI0 N. A. N. A. Phase 4 [387]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [188]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [266]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [325]
Methotrexate DM2TEOL Anterior urethra cancer Approved [737]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [939]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [336]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [411]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [574]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [940]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [941]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proheparin-binding EGF-like growth factor (HBEGF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [186]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [942]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [943]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [351]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [351]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [496]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [313]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [334]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Krueppel-like factor 6 (KLF6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [257]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [944]
Selenium DM25CGV N. A. N. A. Approved [188]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [336]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 5 (MAP3K5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [188]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [290]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [945]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [946]
Efavirenz DMC0GSJ Human immunodeficiency virus infection 1C62 Approved [947]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [809]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [948]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cell division control protein 6 homolog (CDC6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [339]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [336]
Quercetin DM3NC4M Obesity 5B81 Approved [508]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [231]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [774]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Growth/differentiation factor 15 (GDF15)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [322]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [461]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [325]
Quercetin DM3NC4M Obesity 5B81 Approved [508]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [949]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [351]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [351]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [950]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [951]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By SOSS complex subunit B1 (NABP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [390]
Nicotinamide DMUPE07 Acne vulgaris ED80 Approved [952]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [953]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [954]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [952]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By Protein pelota homolog (PELO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [384]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [334]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [514]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [22]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [22]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By TIMELESS-interacting protein (TIPIN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Testosterone enanthate DMB6871 N. A. N. A. Approved [291]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [22]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [955]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [22]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [22]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cell cycle regulator of non-homologous end joining (CYREN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [488]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [223]
Urethane DM7NSI0 N. A. N. A. Phase 4 [387]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [298]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [347]
Torcetrapib DMDHYM7 Hyperlipidaemia 5C80 Discontinued in Phase 2 [524]
COUMESTROL DM40TBU Discovery agent N.A. Investigative [956]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase recruitment domain-containing protein 10 (CARD10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [223]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [353]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [932]
Menthol DMG2KW7 Back pain ME84.Z Approved [277]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [356]
Arsenic DMTL2Y1 N. A. N. A. Approved [957]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [780]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Angiotensin-converting enzyme 2 (ACE2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Captopril DM458UM Chronic heart failure BD1Z Approved [958]
Diazepam DM08E9O Alcohol withdrawal Approved [959]
Dantrolene DM1D8XY Hyperthermia MG26 Approved [959]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [959]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [959]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [959]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [959]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [959]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [959]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [959]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sulfiredoxin-1 (SRXN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [186]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [297]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [960]
Ethacrynic acid DM60QMR Edema MG29 Approved [961]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [480]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [338]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [338]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By tRNA pseudouridine(38/39) synthase (PUS3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [334]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [22]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [22]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [22]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Homeodomain-interacting protein kinase 2 (HIPK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [188]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [329]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [334]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [527]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase PLK3 (PLK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [271]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [334]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [338]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [338]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [366]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transmembrane protein 185B (TMEM185B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [22]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [22]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [22]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [363]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [285]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interferon-stimulated 20 kDa exonuclease-like 2 (ISG20L2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [22]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [22]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [22]
Indomethacin DMSC4A7 Bursitis Approved [367]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [205]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [285]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
Adenine DMZLHKJ Malnutrition 5B50-5B71 Approved [22]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By GrpE protein homolog 1, mitochondrial (GRPEL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Quercetin DM3NC4M Obesity 5B81 Approved [962]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [349]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [334]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [22]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [22]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [22]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [239]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [449]
Selenium DM25CGV N. A. N. A. Approved [188]
Methotrexate DM2TEOL Anterior urethra cancer Approved [318]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [576]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [313]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [334]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Programmed cell death 1 ligand 1 (CD274)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [963]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Panobinostat DM58WKG Chronic graft versus host disease Approved [964]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [325]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [965]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [499]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [966]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Forkhead box protein J2 (FOXJ2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [297]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [22]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [22]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [22]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
Adenine DMZLHKJ Malnutrition 5B50-5B71 Approved [22]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [420]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [271]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By rRNA methyltransferase 2, mitochondrial (MRM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [22]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [350]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [22]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [22]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA helicase MCM8 (MCM8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [339]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [457]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [955]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [386]
Arsenic DMTL2Y1 N. A. N. A. Approved [344]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Frizzled-1 (FZD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [319]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [334]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [499]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [22]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [967]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [22]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Calcium-binding protein 39 (CAB39)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [499]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [531]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
Camptothecin DM6CHNJ Solid tumour/cancer 2A00-2F9Z Phase 3 [531]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [436]
Geldanamycin DMS7TC5 Kidney cancer 2C90.0 Discontinued in Phase 2 [450]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [968]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By 5'-AMP-activated protein kinase subunit beta-1 (PRKAB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [338]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [338]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [338]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [381]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [969]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [22]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [970]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sestrin-1 (SESN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [392]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [374]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [552]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [627]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [338]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [830]
Verapamil DMA7PEW Angina pectoris BA40 Approved [971]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [303]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [392]
Selenium DM25CGV N. A. N. A. Approved [188]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [972]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [466]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [467]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [973]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Molybdenum cofactor sulfurase (MOCOS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [349]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [319]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [183]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [285]
Lucanthone DMZLBUO Solid tumour/cancer 2A00-2F9Z Approved [974]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tripartite motif-containing protein 2 (TRIM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [271]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [325]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [499]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [205]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By V-type proton ATPase 116 kDa subunit a 4 (ATP6V0A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [514]
Folic Acid DMEMBJC Colorectal carcinoma Approved [375]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [356]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [975]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [881]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [347]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [421]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Insulin-like growth factor-binding protein 7 (IGFBP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [449]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [297]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [503]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [716]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Folic Acid DMEMBJC Colorectal carcinoma Approved [375]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [955]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Acid ceramidase (ASAH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [976]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [448]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [977]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [925]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [976]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [977]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Fluoxetine DM3PD2C Bipolar depression Approved [976]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [977]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By D-3-phosphoglycerate dehydrogenase (PHGDH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [310]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [310]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [349]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [338]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [338]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Calcipressin-1 (RCAN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [978]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [979]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [357]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [357]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [978]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Melanoma antigen recognized by T-cells 1 (MLANA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [349]
Vemurafenib DM62UG5 Melanoma 2C30 Approved [980]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
PDX-101 DM6OC53 Plasma cell myeloma 2A83.1 Phase 2 [359]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [347]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [271]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By Serine palmitoyltransferase small subunit A (SPTSSA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [488]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [183]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [490]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [390]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [981]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [982]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Large neutral amino acids transporter small subunit 1 (SLC7A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [504]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [187]
Selenium DM25CGV N. A. N. A. Approved [188]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [352]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [385]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [349]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [342]
Estrone DM5T6US Acne vulgaris ED80 Approved [504]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Chitinase-3-like protein 1 (CHI3L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [462]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [349]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [983]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [576]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [334]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [353]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [955]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [984]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Syncytin-2 (ERVFRD-1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [985]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [986]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [21]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [21]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [987]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [986]
Milchsaure DM462BT Pruritus EC90 Investigative [988]
Forskolin DM6ITNG Solid tumour/cancer 2A00-2F9Z Investigative [989]
Anandamide DMCKH3P Discovery agent N.A. Investigative [990]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By DNA-directed RNA polymerase I subunit RPA12 (POLR1H)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [457]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [334]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [275]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
Sodium phenylbutyrate DMXLBCQ Spinal muscular atrophy 8B61 Approved [991]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [935]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein FAM171A1 (FAM171A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [366]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [748]
Arsenic DMTL2Y1 N. A. N. A. Approved [344]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [223]
Methotrexate DM2TEOL Anterior urethra cancer Approved [21]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fatty acid CoA ligase Acsl3 (ACSL3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluoxetine DM3PD2C Bipolar depression Approved [992]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [349]
Testosterone DM7HUNW Hot flushes GA30 Approved [286]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [905]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Capsaicin DMGMF6V Back pain ME84.Z Approved [993]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [528]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Platelet-derived growth factor C (PDGFC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [601]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [275]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [356]
Arsenic DMTL2Y1 N. A. N. A. Approved [994]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [298]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin receptor substrate 2 (IRS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [462]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [451]
Testosterone DM7HUNW Hot flushes GA30 Approved [995]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [275]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [996]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [997]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [183]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [998]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear protein 1 (NUPR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [257]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [976]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [977]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [999]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [976]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [976]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Fluoxetine DM3PD2C Bipolar depression Approved [976]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [462]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [977]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proteinase-activated receptor 1 (F2R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [225]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [187]
Selenium DM25CGV N. A. N. A. Approved [188]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1000]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [1001]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [313]
Lenalidomide DM6Q7U4 Adult T-cell leukemia/lymphoma Approved [1002]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [1002]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Roundabout homolog 1 (ROBO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [503]
Testosterone DM7HUNW Hot flushes GA30 Approved [286]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [390]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [1003]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [1004]
Arsenic DMTL2Y1 N. A. N. A. Approved [344]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA repair nuclease/redox regulator APEX1 (APEX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [782]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [294]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [1003]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [386]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [1005]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [538]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lymphokine-activated killer T-cell-originated protein kinase (PBK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [227]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [1006]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G-protein-signaling modulator 2 (GPSM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [925]
Methotrexate DM2TEOL Anterior urethra cancer Approved [227]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Testosterone enanthate DMB6871 N. A. N. A. Approved [291]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [934]
Promegestone DMK4S8I Gynecological disease GA6Z Approved [1007]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CD40 ligand (CD40LG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1008]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1009]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [1001]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [1010]
Asasantin DMCZIHT Cerebrovascular ischaemia 8B1Z Approved [315]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [1011]
Menthol DMG2KW7 Back pain ME84.Z Approved [277]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [779]
Eptifibatide DMQXTJS Acute cardiac ischemic events BA40.Z Approved [1012]
Candesartan DMRK8OT Chronic heart failure BD1Z Approved [1011]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Monocarboxylate transporter 7 (SLC16A6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [325]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [385]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [573]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [313]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [1013]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [338]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Homeobox protein engrailed-2 (EN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [285]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [21]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [347]
Calphostin C DM9X2D0 N. A. N. A. Terminated [1014]
CH-223191 DMMJZYC Solid tumour/cancer 2A00-2F9Z Investigative [1015]
Drug(s) Affected By Ras-related protein Rab-17 (RAB17)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [353]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [330]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [1016]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [390]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [21]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [298]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fibroblast growth factor 2 (FGF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [1017]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [601]
Diazepam DM08E9O Alcohol withdrawal Approved [1018]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [1019]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [943]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [1020]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [374]
Isradipine DMA5XGH Hypertension BA00-BA04 Approved [1021]
Valdecoxib DMAY7H4 Osteoarthritis FA00-FA05 Approved [1022]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myelin proteolipid protein (PLP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [450]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [421]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Ethanol DMDRQZU Chronic pain MG30 Approved [1023]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [1024]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [470]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [470]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [864]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [1025]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [252]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [260]
Gefitinib DM15F0X Colon adenocarcinoma Approved [1026]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [897]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [1027]
Selenium DM25CGV N. A. N. A. Approved [188]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [821]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [307]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phosphatidylinositol 4-phosphate 5-kinase type-1 beta (PIP5K1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Cholecalciferol DMGU74E Adult acute monocytic leukemia Approved [1028]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [365]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [363]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [1029]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neuronal membrane glycoprotein M6-b (GPM6B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [310]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [310]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [450]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Testosterone enanthate DMB6871 N. A. N. A. Approved [291]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [310]
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [1030]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Melanoma-associated antigen 12 (MAGEA12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [295]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [1031]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [345]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [21]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [347]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By Solute carrier family 22 member 18 (SLC22A18)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Selenium DM25CGV N. A. N. A. Approved [188]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [329]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [385]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [349]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [503]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [229]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Thymosin beta-4 (TMSB4X)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [351]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [1032]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [451]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [528]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [288]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [1033]
Indomethacin DMSC4A7 Bursitis Approved [1034]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [1035]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Follicle-stimulating hormone receptor (FSHR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [238]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [238]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [238]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [1036]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [347]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [1037]
MICROCYSTIN-LR DMTMLRN Discovery agent N.A. Investigative [1038]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By Oxidoreductase HTATIP2 (HTATIP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [305]
Testosterone DM7HUNW Hot flushes GA30 Approved [286]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [338]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [338]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [928]
Testosterone enanthate DMB6871 N. A. N. A. Approved [291]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [928]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 (ST6GALNAC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1039]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [353]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [382]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [366]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [1016]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [485]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [379]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [421]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Splicing factor 45 (RBM17)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [287]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [319]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [1040]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [205]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [1041]
Pemetrexed DMMX2E6 Central nervous system lymphoma 2B33.5 Approved [1041]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CD44 antigen (CD44)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [239]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [504]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Selenium DM25CGV N. A. N. A. Approved [1042]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [587]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [1043]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [231]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [1044]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [482]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tissue factor pathway inhibitor (TFPI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [504]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Estrone DM5T6US Acne vulgaris ED80 Approved [504]
Testosterone DM7HUNW Hot flushes GA30 Approved [1045]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [381]
Ethanol DMDRQZU Chronic pain MG30 Approved [1023]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Medium-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [329]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [349]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [1046]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [499]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [1047]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [1048]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By POM121 and ZP3 fusion protein (POMZP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [932]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
Paclitaxel DMLB81S Breast carcinoma Approved [21]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [21]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [981]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [379]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [348]
Milchsaure DM462BT Pruritus EC90 Investigative [988]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [381]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transmembrane protein 47 (TMEM47)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [748]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [223]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [1049]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [538]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [390]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [21]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutathione S-transferase theta-2 (GSTT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [382]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [840]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [350]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [454]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [1050]
Artesunate DMR27C8 Infection of P. falciparum 1F40 Approved [1051]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [362]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [1052]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1053]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [336]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [1054]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [588]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [313]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [401]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [183]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 5-hydroxytryptamine receptor 4 (HTR4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [188]
Testosterone DM7HUNW Hot flushes GA30 Approved [286]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [383]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [347]
GR-113808 DMFU9VH Discovery agent N.A. Investigative [1055]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By High mobility group protein HMGI-C (HMGA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [601]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [381]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [955]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [282]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [748]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Chondroitin sulfate N-acetylgalactosaminyltransferase 1 (CSGALNACT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [319]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [313]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [275]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [521]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Microtubule-associated tumor suppressor 1 (MTUS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [313]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [499]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Testosterone enanthate DMB6871 N. A. N. A. Approved [291]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [359]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [183]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [223]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cystathionine gamma-lyase (CTH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [322]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [925]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [349]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [573]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1056]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [313]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [322]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [338]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Melanocyte protein PMEL (PMEL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluoxetine DM3PD2C Bipolar depression Approved [992]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [349]
Vemurafenib DM62UG5 Melanoma 2C30 Approved [980]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [932]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [357]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [183]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [454]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [285]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [359]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By BMP and activin membrane-bound inhibitor homolog (BAMBI)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [501]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [297]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [503]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [313]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [381]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Alkaline phosphatase, germ cell type (ALPG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [1057]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [924]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [1058]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [1057]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [1059]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [1060]
Lithium chloride DMHYLQ2 Discovery agent N.A. Investigative [905]
Hydroxyestradiol DMJXQME N. A. N. A. Investigative [1058]
Sulforaphane DMQY3L0 Skin disease EA00-EM0Z Investigative [487]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Creatine kinase U-type, mitochondrial (CKMT1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [297]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Folic Acid DMEMBJC Colorectal carcinoma Approved [375]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [360]
Methotrexate DM2TEOL Anterior urethra cancer Approved [21]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [21]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [21]
Afimoxifene DMFORDT Breast cancer 2C60-2C65 Phase 2 [1061]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [347]
dibutyl phthalate DMEDGKO Discovery agent N.A. Investigative [1062]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Reserpine DM6VM38 Hypertension BA00-BA04 Approved [175]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [356]
Chloroquine DMSI5CB Malaria 1F40-1F45 Approved [1063]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [183]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [363]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [538]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ras-interacting protein 1 (RASIP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Arsenic DMTL2Y1 N. A. N. A. Approved [344]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [359]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [347]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [379]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [1064]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By Collagen alpha-3(IX) chain (COL9A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [390]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [21]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [298]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [179]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [1065]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By A-kinase anchor protein 12 (AKAP12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [501]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [481]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [462]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [929]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [1066]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [499]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interferon-stimulated gene 20 kDa protein (ISG20)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [310]
Aripiprazole DM3NUMH Bipolar I disorder Approved [1067]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [310]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [481]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [310]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Stathmin (STMN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [303]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [364]
Etretinate DM2CZFA Keratosis ED56 Approved [189]
Quercetin DM3NC4M Obesity 5B81 Approved [962]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [311]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1068]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [1069]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [187]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [1070]
Methotrexate DM2TEOL Anterior urethra cancer Approved [318]
Quercetin DM3NC4M Obesity 5B81 Approved [1071]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [297]
Levamisole DM5EN79 Parasitic infection 1D0Y-1G2Z Approved [1072]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1073]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [1074]
Promethazine DM6I5GR Hyperemesis gravidarum Approved [1075]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dickkopf-related protein 3 (DKK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [271]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [297]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [319]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [334]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [275]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Folic Acid DMEMBJC Colorectal carcinoma Approved [918]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [924]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By P protein (OCA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [350]
Arsenic DMTL2Y1 N. A. N. A. Approved [344]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [347]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [271]
acetaldehyde DMJFKG4 Discovery agent N.A. Investigative [380]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By Cystatin-SN (CST1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Lucanthone DMZLBUO Solid tumour/cancer 2A00-2F9Z Approved [974]
Methotrexate DM2TEOL Anterior urethra cancer Approved [21]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [347]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [982]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By Alternative prion protein (PRNP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [187]
Methotrexate DM2TEOL Anterior urethra cancer Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [231]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [499]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [932]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [1076]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [1077]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [1077]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fructose-bisphosphate aldolase C (ALDOC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [287]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Fluoxetine DM3PD2C Bipolar depression Approved [992]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [290]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [297]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [503]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [1078]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interferon-induced transmembrane protein 1 (IFITM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Selenium DM25CGV N. A. N. A. Approved [188]
Methotrexate DM2TEOL Anterior urethra cancer Approved [295]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [908]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [349]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [313]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [353]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [275]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Epidermal growth factor-like protein 8 (EGFL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [390]
Arsenic DMTL2Y1 N. A. N. A. Approved [344]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [330]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [379]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [421]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By dTDP-D-glucose 4,6-dehydratase (TGDS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [935]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [21]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [347]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [379]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [1079]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [1080]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [1081]
Gefitinib DM15F0X Colon adenocarcinoma Approved [1082]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [635]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [1083]
Quercetin DM3NC4M Obesity 5B81 Approved [564]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [1084]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [1085]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [1083]
Ethacrynic acid DM60QMR Edema MG29 Approved [1086]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ras association domain-containing protein 1 (RASSF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [188]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1087]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [334]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [390]
Folic Acid DMEMBJC Colorectal carcinoma Approved [918]
Procainamide DMNMXR8 Ventricular arrhythmias BC71 Approved [1088]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [1089]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [386]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor SOX-10 (SOX10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [353]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Folic Acid DMEMBJC Colorectal carcinoma Approved [433]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [433]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [298]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [347]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [421]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Eukaryotic translation initiation factor 3 subunit A (EIF3A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Quercetin DM3NC4M Obesity 5B81 Approved [962]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [231]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [381]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [1090]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [1091]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [363]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sortilin (SORT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [287]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [349]
Testosterone DM7HUNW Hot flushes GA30 Approved [1092]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [288]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Kelch-like ECH-associated protein 1 (KEAP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [1093]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [501]
Selenium DM25CGV N. A. N. A. Approved [188]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [621]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [1094]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [338]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [338]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [338]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [856]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [1095]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myelin basic protein (MBP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [1096]
Testosterone DM7HUNW Hot flushes GA30 Approved [286]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [421]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [933]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Clozapine DMFC71L Schizophrenia 6A20 Approved [1097]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [288]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein AF1q (MLLT11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [19]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [290]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [496]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [390]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [356]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Bortezomib DMNO38U Leukemia Approved [383]
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [1030]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tudor domain-containing protein 3 (TDRD3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [295]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [231]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [275]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [357]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [357]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [363]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [21]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Enhancer of filamentation 1 (NEDD9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [351]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [351]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [338]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [338]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [338]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [338]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Squalene synthase (FDFT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [1098]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Fluoxetine DM3PD2C Bipolar depression Approved [992]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [297]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [349]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [1099]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [401]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Voltage-gated potassium channel subunit beta-2 (KCNAB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [231]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [386]
Arsenic DMTL2Y1 N. A. N. A. Approved [344]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [360]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [1100]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [21]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [1100]
Urethane DM7NSI0 N. A. N. A. Phase 4 [387]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual specificity protein phosphatase 2 (DUSP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Methotrexate DM2TEOL Anterior urethra cancer Approved [268]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [297]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [319]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [1101]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [276]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [381]
Epanova DMHEAGL Hypertriglyceridemia 5C80.1 Approved [1102]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [366]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [282]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sigma intracellular receptor 2 (TMEM97)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [297]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [349]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [319]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [313]
Testosterone DM7HUNW Hot flushes GA30 Approved [286]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [356]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Melanoma-associated antigen C1 (MAGEC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [423]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [454]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [747]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [981]
Drug(s) Affected By Tribbles homolog 2 (TRIB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [188]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [930]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [319]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [382]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [214]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [223]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [1103]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA damage-inducible transcript 4 protein (DDIT4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [322]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [925]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [22]
Methotrexate DM2TEOL Anterior urethra cancer Approved [340]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [1104]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [573]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [374]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [552]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By BAG family molecular chaperone regulator 2 (BAG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [925]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [353]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Menthol DMG2KW7 Back pain ME84.Z Approved [277]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nucleosome assembly protein 1-like 1 (NAP1L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [925]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [1105]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [231]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [319]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [931]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [275]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [933]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Melanoma-associated antigen 6 (MAGEA6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [1106]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [345]
Methotrexate DM2TEOL Anterior urethra cancer Approved [21]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [21]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [21]
GALLICACID DM6Y3A0 Discovery agent N.A. Investigative [1107]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By Prosaposin receptor GPR37 (GPR37)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [450]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Folic Acid DMEMBJC Colorectal carcinoma Approved [375]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [454]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [285]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [377]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [360]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Kynureninase (KYNU)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [504]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [836]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [462]
Estrone DM5T6US Acne vulgaris ED80 Approved [504]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [305]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [334]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [381]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lysosomal acid lipase/cholesteryl ester hydrolase (LIPA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Haloperidol DM96SE0 Delirium Approved [287]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [932]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Benzatropine DMF7EXL Parkinsonian disorder Approved [287]
Clozapine DMFC71L Schizophrenia 6A20 Approved [287]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [288]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [386]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Baculoviral IAP repeat-containing protein 7 (BIRC7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1009]
Testosterone DM7HUNW Hot flushes GA30 Approved [286]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Bortezomib DMNO38U Leukemia Approved [1108]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [1109]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [1110]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [1111]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [1111]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [1112]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Runt-related transcription factor 3 (RUNX3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [1113]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [276]
Gentamicin DMKINJO Bacteremia 1A73 Approved [1113]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [997]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [1113]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [1114]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [1113]
Arsenic DMTL2Y1 N. A. N. A. Approved [344]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein S100-P (S100P)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [257]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [1115]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [461]
Quercetin DM3NC4M Obesity 5B81 Approved [508]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [462]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [589]
Estrone DM5T6US Acne vulgaris ED80 Approved [1116]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [313]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [1117]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Osteopontin (SPP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [1118]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [155]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1119]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [1120]
Quercetin DM3NC4M Obesity 5B81 Approved [477]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [1121]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [231]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [1122]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [342]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By cAMP-responsive element modulator (CREM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [295]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [319]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [1003]
Bortezomib DMNO38U Leukemia Approved [383]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [473]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [223]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [427]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Alpha-(1,6)-fucosyltransferase (FUT8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [271]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [349]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [353]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [390]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [356]
Pyridoxal Phosphate DMO2K0J Malnutrition 5B50-5B71 Approved [1123]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Trefoil factor 3 (TFF3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [731]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [1124]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [205]
Arsenic DMTL2Y1 N. A. N. A. Approved [1125]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [454]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [731]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [376]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [21]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor-like 5 protein (TCFL5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [295]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [488]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
PHENOL DM1QSM3 N. A. N. A. Phase 2/3 [929]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [347]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Uncharacterized protein C4orf19 (C4ORF19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [356]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [223]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [1049]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [298]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [362]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [347]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [379]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sorbin and SH3 domain-containing protein 2 (SORBS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Testosterone DM7HUNW Hot flushes GA30 Approved [286]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [365]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [924]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [223]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [179]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myc box-dependent-interacting protein 1 (BIN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Selenium DM25CGV N. A. N. A. Approved [188]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [329]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Ethanol DMDRQZU Chronic pain MG30 Approved [1126]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Paclitaxel DMLB81S Breast carcinoma Approved [505]
Bortezomib DMNO38U Leukemia Approved [1127]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transmembrane channel-like protein 6 (TMC6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [295]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [231]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [313]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [499]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [1128]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [350]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [365]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [186]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [156]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [836]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [156]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [156]
Methotrexate DM2TEOL Anterior urethra cancer Approved [310]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [738]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Fluoxetine DM3PD2C Bipolar depression Approved [480]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [156]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By B-cell receptor-associated protein 31 (BCAP31)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [349]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [183]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
Diphenylpyraline DMW4X37 Allergic rhinitis CA08.0 Approved [781]
Aminoglutethimide DMWFHMZ Cushing disease 5A70 Approved [1129]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [1057]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [188]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myelin P2 protein (PMP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [334]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Folic Acid DMEMBJC Colorectal carcinoma Approved [375]
Urethane DM7NSI0 N. A. N. A. Phase 4 [387]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [359]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [347]
Milchsaure DM462BT Pruritus EC90 Investigative [988]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By Cytochrome P450 26A1 (CYP26A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [1130]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [1131]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [1130]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [1132]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [730]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [401]
Dolutegravir DMCZGRE Human immunodeficiency virus infection 1C62 Approved [1133]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [1130]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [1134]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [486]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone-binding protein RBBP7 (RBBP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [364]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [1076]
Promegestone DMK4S8I Gynecological disease GA6Z Approved [1007]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [223]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [364]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glycylpeptide N-tetradecanoyltransferase 2 (NMT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [319]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [998]
Arsenic DMTL2Y1 N. A. N. A. Approved [344]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [21]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tyrosine-protein kinase Fyn (FYN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [1135]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [231]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [589]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Ethanol DMDRQZU Chronic pain MG30 Approved [1136]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [481]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [997]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [748]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Homeobox protein Hox-A5 (HOXA5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1137]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [183]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [285]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA cytosine-5)-methyltransferase 1 (DNMT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [553]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1138]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [1139]
Quercetin DM3NC4M Obesity 5B81 Approved [477]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1140]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [1141]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [1142]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1143]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [1144]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lymphocyte antigen 6E (LY6E)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [188]
Methotrexate DM2TEOL Anterior urethra cancer Approved [310]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [231]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [310]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [313]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [310]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [310]
Prednisolone DMQ8FR2 Acute adrenal insufficiency Approved [310]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bridging integrator 3 (BIN3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Paclitaxel DMLB81S Breast carcinoma Approved [916]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [21]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [436]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [271]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Bcl-2-like protein 2 (BCL2L2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [155]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [1145]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1009]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [661]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Menthol DMG2KW7 Back pain ME84.Z Approved [277]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [779]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [1146]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone-lysine N-methyltransferase 2B (KMT2B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [188]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [231]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Ethanol DMDRQZU Chronic pain MG30 Approved [891]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [231]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [188]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [379]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [420]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Copper-transporting ATPase 1 (ATP7A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [930]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Paclitaxel DMLB81S Breast carcinoma Approved [201]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [1147]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [1148]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [1149]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [1149]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [1150]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor AP-2-alpha (TFAP2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [1151]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [504]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [1152]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1153]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Paroxetine DM5PVQE Anxiety disorder 6B00-6B0Z Approved [1151]
Testosterone DM7HUNW Hot flushes GA30 Approved [286]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [353]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [338]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [338]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein kinase C zeta type (PRKCZ)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [286]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [1154]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Arsenic DMTL2Y1 N. A. N. A. Approved [344]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [223]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [818]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [1155]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Four and a half LIM domains protein 1 (FHL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1156]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Folic Acid DMEMBJC Colorectal carcinoma Approved [1157]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [383]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [955]
Isoproterenol DMK7MEY Atrioventricular block Approved [1158]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [523]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Epithelial splicing regulatory protein 1 (ESRP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [1159]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1160]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [353]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [205]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [390]
Topotecan DMP6G8T Central nervous system neoplasm Approved [21]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [298]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Beta-secretase 2 (BACE2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [275]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Clozapine DMFC71L Schizophrenia 6A20 Approved [1161]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [183]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [363]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [1049]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [360]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [297]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [305]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [313]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [1162]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [499]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [381]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [356]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [350]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [787]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hypoxanthine-guanine phosphoribosyltransferase (HPRT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Thioguanine DM7NKEV Acute lymphocytic leukaemia 2B33.3 Approved [1163]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [782]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [1164]
Methotrexate DM2TEOL Anterior urethra cancer Approved [268]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [410]
Fructose DM43AN2 Vomiting MD90 Approved [479]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [1165]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myeloperoxidase (MPO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dapsone DM4LT8A Acne vulgaris ED80 Approved [175]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [386]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [175]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [175]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1166]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [1167]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [1168]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [1169]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1170]
Propylthiouracil DM6D7N8 Hyperthyroidism 5A02 Approved [1171]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutathione S-transferase Mu 4 (GSTM4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [448]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [374]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Bortezomib DMNO38U Leukemia Approved [383]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [1172]
Arsenic DMTL2Y1 N. A. N. A. Approved [344]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [359]
Methotrexate DM2TEOL Anterior urethra cancer Approved [1173]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [252]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [271]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1174]
Methotrexate DM2TEOL Anterior urethra cancer Approved [268]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [1139]
Quercetin DM3NC4M Obesity 5B81 Approved [273]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [297]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1175]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [1176]
Testosterone DM7HUNW Hot flushes GA30 Approved [286]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-4 (IL4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [1177]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [1178]
Tolnaftate DM28MU7 Dermatophytosis 1F28.2 Approved [1179]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [1180]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [1181]
Prednisone DM2HG4X Acute asthma CA23 Approved [1182]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [1183]
Methotrexate DM2TEOL Anterior urethra cancer Approved [268]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [1184]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [1185]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ras-related protein Rab-20 (RAB20)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [295]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [381]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [527]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [1057]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [223]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [334]
Testosterone DM7HUNW Hot flushes GA30 Approved [286]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Testosterone enanthate DMB6871 N. A. N. A. Approved [291]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [390]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [381]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Artesunate DMR27C8 Infection of P. falciparum 1F40 Approved [1186]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Epithelial membrane protein 2 (EMP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [188]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1187]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1188]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [205]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [223]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [1189]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [490]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ropporin-1A (ROPN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [347]
Drug(s) Affected By Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [830]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Ethanol DMDRQZU Chronic pain MG30 Approved [1126]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [1190]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [205]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [284]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclic GMP-AMP phosphodiesterase SMPDL3A (SMPDL3A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [205]
Arsenic DMTL2Y1 N. A. N. A. Approved [841]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [363]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [1049]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [474]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [376]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone deacetylase 4 (HDAC4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [271]
Quercetin DM3NC4M Obesity 5B81 Approved [477]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [374]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [1032]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [1191]
Bortezomib DMNO38U Leukemia Approved [1127]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [748]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (ANKRD28)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [297]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [933]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [381]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [282]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [214]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [223]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [252]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1192]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [266]
Selenium DM25CGV N. A. N. A. Approved [188]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [1193]
Methotrexate DM2TEOL Anterior urethra cancer Approved [318]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [261]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [563]
Quercetin DM3NC4M Obesity 5B81 Approved [564]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [410]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Disabled homolog 2 (DAB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1153]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [374]
Exemestane DM9HPW3 Hormonally-responsive breast cancer 2C60-2C65 Approved [370]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [275]
Testosterone enanthate DMB6871 N. A. N. A. Approved [291]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Ethanol DMDRQZU Chronic pain MG30 Approved [293]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Large ribosomal subunit protein eL6 (RPL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [364]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1073]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [933]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [363]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [364]
Artesunate DMR27C8 Infection of P. falciparum 1F40 Approved [1194]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [1195]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Band 4.1-like protein 3 (EPB41L3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [313]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [382]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [1196]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [386]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutathione S-transferase Mu 1 (GSTM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Busulfan DMXYJ9C Chronic myelogenous leukaemia 2A20.0 Approved [182]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [1197]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [21]
Ethanol DMDRQZU Chronic pain MG30 Approved [1198]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [351]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [351]
Methyldopa DM5I621 Hypertension BA00-BA04 Approved [1199]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [319]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heat shock-related 70 kDa protein 2 (HSPA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [257]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Quercetin DM3NC4M Obesity 5B81 Approved [617]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [411]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [860]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [1200]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [627]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By MyoD family inhibitor domain-containing protein (MDFIC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [589]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [499]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [183]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [818]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [1201]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [359]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Terminal nucleotidyltransferase 5A (TENT5A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [836]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [621]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [298]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [350]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [386]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Collagen alpha-1(XV) chain (COL15A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [334]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [730]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [390]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [288]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [924]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [183]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [1201]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [1202]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [1203]
Methotrexate DM2TEOL Anterior urethra cancer Approved [1204]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl-2-interacting killer (BIK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1205]
Methotrexate DM2TEOL Anterior urethra cancer Approved [326]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [433]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [589]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [940]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Clozapine DMFC71L Schizophrenia 6A20 Approved [1206]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase Chk1 (CHEK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [339]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [461]
Methotrexate DM2TEOL Anterior urethra cancer Approved [669]
Quercetin DM3NC4M Obesity 5B81 Approved [564]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [784]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [585]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1207]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [1208]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Max-interacting protein 1 (MXI1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [352]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [338]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [338]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [338]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [381]
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [1209]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [350]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Calcium-dependent secretion activator 2 (CADPS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [1029]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [1210]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [360]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [21]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [521]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Forkhead box protein F2 (FOXF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [188]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [353]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [183]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [360]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [1100]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [21]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [1100]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [1211]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Metastasis-associated in colon cancer protein 1 (MACC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [271]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [1049]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [390]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [298]
PDX-101 DM6OC53 Plasma cell myeloma 2A83.1 Phase 2 [298]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [881]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [347]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutathione S-transferase LANCL1 (LANCL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [21]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [379]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [1212]
taurine DMVW7N3 Discovery agent N.A. Investigative [1213]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Matrilin-2 (MATN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [462]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [1214]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [450]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [481]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [214]
Arsenic DMTL2Y1 N. A. N. A. Approved [344]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [454]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5 (MACF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [271]
Selenium DM25CGV N. A. N. A. Approved [188]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [297]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [621]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [522]
Testosterone enanthate DMB6871 N. A. N. A. Approved [291]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [183]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Poly polymerase tankyrase-1 (TNKS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [334]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [21]
Urethane DM7NSI0 N. A. N. A. Phase 4 [387]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [1215]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [379]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ensconsin (MAP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [305]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [353]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [421]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [357]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [183]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [363]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [474]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [390]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Integrin beta-3 (ITGB3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [1216]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [1217]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1218]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [928]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [1219]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [316]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [484]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [183]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [330]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [494]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By N-myc proto-oncogene protein (MYCN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [252]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [693]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1220]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [333]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1221]
LY2835219 DM93VBZ Breast cancer 2C60-2C65 Approved [1222]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Emetine DMCT2YF Hepatitis virus infection 1E50-1E51 Approved [1223]
Menthol DMG2KW7 Back pain ME84.Z Approved [277]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sorbin and SH3 domain-containing protein 1 (SORBS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [420]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [349]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [412]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Testosterone enanthate DMB6871 N. A. N. A. Approved [291]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [932]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [381]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [288]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [183]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [434]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Anamorsin (CIAPIN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [564]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [334]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [1224]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [747]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [347]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [420]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [1212]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Inositol 1,4,5-trisphosphate receptor type 1 (ITPR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [836]
Methotrexate DM2TEOL Anterior urethra cancer Approved [318]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [297]
Procaine DM4LSNE Anaesthesia 9A78.6 Approved [1225]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1160]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [381]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [374]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [390]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [484]
Arsenic DMTL2Y1 N. A. N. A. Approved [344]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [935]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [21]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [21]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [21]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Long-chain fatty acid transport protein 3 (SLC27A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [257]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [1226]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [288]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [183]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [363]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin-like growth factor 1 receptor (IGF1R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [1227]
Gefitinib DM15F0X Colon adenocarcinoma Approved [1228]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [821]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [1229]
Quercetin DM3NC4M Obesity 5B81 Approved [477]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [921]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [837]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [338]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Estrogen receptor beta (ESR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [155]
Gefitinib DM15F0X Colon adenocarcinoma Approved [1230]
Quercetin DM3NC4M Obesity 5B81 Approved [426]
Estrone DM5T6US Acne vulgaris ED80 Approved [1231]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [1232]
Testosterone DM7HUNW Hot flushes GA30 Approved [1233]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [1234]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [1235]
Mestranol DMG3F94 Contraception QA21 Approved [1236]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [1237]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Coiled-coil domain-containing protein 6 (CCDC6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [836]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [390]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Bortezomib DMNO38U Leukemia Approved [383]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [386]
Arsenic DMTL2Y1 N. A. N. A. Approved [344]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [420]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Arginine vasopressin-induced protein 1 (AVPI1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone DM7HUNW Hot flushes GA30 Approved [286]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [356]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [350]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [748]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [223]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [935]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Carbamoyl-phosphate synthase , mitochondrial (CPS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Quercetin DM3NC4M Obesity 5B81 Approved [617]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [401]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [481]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [840]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Flucloxacillin DMNUWST Bacterial infection 1A00-1C4Z Approved [1238]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peripheral myelin protein 22 (PMP22)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Testosterone DM7HUNW Hot flushes GA30 Approved [286]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [421]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [288]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [1239]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [183]
Arsenic DMTL2Y1 N. A. N. A. Approved [1240]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related (HMG20B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [522]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [537]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [21]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [21]
Urethane DM7NSI0 N. A. N. A. Phase 4 [387]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [747]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [379]
geraniol DMS3CBD Discovery agent N.A. Investigative [1241]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Protein Niban 1 (NIBAN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [188]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [297]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1242]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [313]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [499]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [502]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [932]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Ethanol DMDRQZU Chronic pain MG30 Approved [1023]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [356]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By LIM and calponin homology domains-containing protein 1 (LIMCH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [188]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [349]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [499]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [522]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Ethanol DMDRQZU Chronic pain MG30 Approved [1023]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [356]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Galectin-3 (LGALS3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [869]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [915]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [319]
Testosterone DM7HUNW Hot flushes GA30 Approved [286]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [915]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [932]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By L-dopachrome tautomerase (DCT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [765]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [330]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [185]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [185]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [21]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [1243]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [175]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [1244]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [1245]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By PRA1 family protein 3 (ARL6IP5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1246]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [1032]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [451]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [932]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [1030]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA (DNMT3B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1140]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1247]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [1144]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [390]
Ethanol DMDRQZU Chronic pain MG30 Approved [891]
Folic Acid DMEMBJC Colorectal carcinoma Approved [375]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Calcitonin (CALCA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [1248]
Fructose DM43AN2 Vomiting MD90 Approved [479]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [932]
Folic Acid DMEMBJC Colorectal carcinoma Approved [375]
Nizatidine DMGFV3Z Acid-reflux disorder DA22 Approved [1248]
Capsaicin DMGMF6V Back pain ME84.Z Approved [1249]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [1250]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hephaestin (HEPH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [205]
Selenium DM25CGV N. A. N. A. Approved [188]
Testosterone enanthate DMB6871 N. A. N. A. Approved [291]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [381]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [955]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [205]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [298]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [347]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Complement decay-accelerating factor (CD55)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [239]
Methotrexate DM2TEOL Anterior urethra cancer Approved [1251]
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [462]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [590]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [451]
Testosterone DM7HUNW Hot flushes GA30 Approved [286]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tissue factor pathway inhibitor 2 (TFPI2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [297]
Panobinostat DM58WKG Chronic graft versus host disease Approved [298]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [334]
Testosterone DM7HUNW Hot flushes GA30 Approved [286]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [179]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [356]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin-induced gene 1 protein (INSIG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [925]
Fluoxetine DM3PD2C Bipolar depression Approved [992]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [481]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [621]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [824]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [349]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [621]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [1032]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [338]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Suppressor of tumorigenicity 7 protein (ST7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [355]
Testosterone DM7HUNW Hot flushes GA30 Approved [320]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [320]
Testosterone enanthate DMB6871 N. A. N. A. Approved [291]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [289]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [748]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [454]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [21]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By UPF0489 protein C5orf22 (C5ORF22)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Leflunomide DMR8ONJ Arthritis FA20 Approved [300]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [321]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [354]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [358]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [747]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [420]
Geldanamycin DMS7TC5 Kidney cancer 2C90.0 Discontinued in Phase 2 [450]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [421]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Alkaline phosphatase, placental type (ALPP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lidocaine DML4ZOT Anaesthesia 9A78.6 Approved [175]
Paricalcitol DMYBV3G Hyperparathyroidism 5A51 Approved [175]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [457]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [329]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1242]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [985]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Isoproterenol DMK7MEY Atrioventricular block Approved [1252]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [924]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [1033]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Drebrin (DBN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [229]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [349]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [576]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [275]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [180]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [292]
Ethanol DMDRQZU Chronic pain MG30 Approved [1253]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [281]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [1003]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
DNA topoisomerase II (TOP2) TT0IHXV TOP2A_HUMAN; TOP2B_HUMAN Modulator [5]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Multidrug resistance-associated protein 3 (ABCC3) DTQ3ZHF MRP3_HUMAN Substrate [6]
Multidrug resistance-associated protein 2 (ABCC2) DTFI42L MRP2_HUMAN Substrate [7]
Organic anion transporting polypeptide 2B1 (SLCO2B1) DTPFTEQ SO2B1_HUMAN Substrate [8]
Multidrug resistance-associated protein 1 (ABCC1) DTSYQGK MRP1_HUMAN Substrate [9]
Breast cancer resistance protein (ABCG2) DTI7UX6 ABCG2_HUMAN Substrate [10]
Organic anion transporting polypeptide 1B1 (SLCO1B1) DT3D8F0 SO1B1_HUMAN Substrate [8]
Organic anion transporting polypeptide 1B3 (SLCO1B3) DT9C1TS SO1B3_HUMAN Substrate [11]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [12]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [13]
Cytochrome P450 2E1 (CYP2E1) DEVDYN7 CP2E1_HUMAN Substrate [14]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Substrate [15]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Substrate [13]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Substrate [16]
Prostaglandin G/H synthase 2 (COX-2) DE492CE PGH2_HUMAN Substrate [17]
Prostaglandin G/H synthase 1 (COX-1) DE073H6 PGH1_HUMAN Substrate [17]
Glutathione S-transferase pi (GSTP1) DEK6079 GSTP1_HUMAN Substrate [18]
Glutathione S-transferase theta-1 (GSTT1) DE3PKUG GSTT1_HUMAN Substrate [18]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Gene/Protein Processing [19]
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (CYP27B1) OTTK98BH CP27B_HUMAN Gene/Protein Processing [20]
3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B) OTOA8WU2 PDE4B_HUMAN Drug Response [21]
5'-AMP-activated protein kinase subunit beta-1 (PRKAB1) OT1OG4QZ AAKB1_HUMAN Gene/Protein Processing [22]
5,6-dihydroxyindole-2-carboxylic acid oxidase OTRK49R4 TYRP1_HUMAN Drug Response [21]
5-hydroxytryptamine receptor 4 (HTR4) OTBIB44K 5HT4R_HUMAN Drug Response [21]
A-kinase anchor protein 12 (AKAP12) OTCVRDDX AKA12_HUMAN Drug Response [21]
Acid ceramidase (ASAH1) OT1DNGXL ASAH1_HUMAN Drug Response [21]
Actin, alpha skeletal muscle (ACTA1) OTOVGLPG ACTS_HUMAN Gene/Protein Processing [23]
Actin-binding Rho-activating protein (ABRA) OTBQ2C1J ABRA_HUMAN Gene/Protein Processing [23]

References

1 Etoposide FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6815).
3 FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (ANDA) 075635.
4 ClinicalTrials.gov (NCT04356690) Etoposide in Patients With COVID-19 Infection. U.S. National Institutes of Health.
5 Etoposide, topoisomerase II and cancer.Curr Med Chem Anticancer Agents.2005 Jul;5(4):363-72.
6 Functional reconstitution of human ABCC3 into proteoliposomes reveals a transport mechanism with positive cooperativity. Biochemistry. 2009 May 26;48(20):4423-30.
7 Delineating the contribution of secretory transporters in the efflux of etoposide using Madin-Darby canine kidney (MDCK) cells overexpressing P-glycoprotein (Pgp), multidrug resistance-associated protein (MRP1), and canalicular multispecific organic anion transporter (cMOAT). Drug Metab Dispos. 2002 Apr;30(4):457-63.
8 Identification of drugs and drug metabolites as substrates of multidrug resistance protein 2 (MRP2) using triple-transfected MDCK-OATP1B1-UGT1A1-MRP2 cells. Br J Pharmacol. 2012 Mar;165(6):1836-1847.
9 Multidrug resistance-associated protein-1 functional activity in Calu-3 cells. J Pharmacol Exp Ther. 2001 Sep;298(3):1199-205.
10 Characterization of 3-methoxy flavones for their interaction with ABCG2 as suggested by ATPase activity. Biochim Biophys Acta. 2014 Nov;1838(11):2929-38.
11 Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3. Eur J Pharmacol. 2008 Apr 14;584(1):57-65.
12 Efflux ratio cannot assess P-glycoprotein-mediated attenuation of absorptive transport: asymmetric effect of P-glycoprotein on absorptive and secretory transport across Caco-2 cell monolayers. Pharm Res. 2003 Aug;20(8):1200-9.
13 Effects of morin on the pharmacokinetics of etoposide in rats. Biopharm Drug Dispos. 2007 Apr;28(3):151-6.
14 A study on the metabolism of etoposide and possible interactions with antitumor or supporting agents by human liver microsomes. J Pharmacol Exp Ther. 1998 Sep;286(3):1294-300.
15 UDP-glucuronosyltransferase 1A1 is the principal enzyme responsible for etoposide glucuronidation in human liver and intestinal microsomes: structural characterization of phenolic and alcoholic glucuronides of etoposide and estimation of enzyme kinetics. Drug Metab Dispos. 2007 Mar;35(3):371-80.
16 Kinetics and regulation of cytochrome P450-mediated etoposide metabolism. Drug Metab Dispos. 2004 Sep;32(9):993-1000.
17 Peroxidative free radical formation and O-demethylation of etoposide(VP-16) and teniposide(VM-26). Biochem Biophys Res Commun. 1986 Feb 26;135(1):215-20.
18 Reactions of glutathione with the catechol, the ortho-quinone and the semi-quinone free radical of etoposide. Consequences for DNA inactivation. Biochem Pharmacol. 1992 Apr 15;43(8):1761-8.
19 Genomic profiling uncovers a molecular pattern for toxicological characterization of mutagens and promutagens in vitro. Toxicol Sci. 2011 Jul;122(1):185-97.
20 Differential regulation of vitamin D receptor (VDR) by the p53 Family: p73-dependent induction of VDR upon DNA damage. J Biol Chem. 2007 Oct 12;282(41):29847-54.
21 Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
22 Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity. Toxicology. 2014 Jan 6;315:8-16. doi: 10.1016/j.tox.2013.10.009. Epub 2013 Nov 6.
23 Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells. Arch Toxicol. 2018 Apr;92(4):1507-1524.
24 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
25 Mitoxantrone, a topoisomerase II inhibitor, induces apoptosis of B-chronic lymphocytic leukaemia cells. Br J Haematol. 1998 Jan;100(1):142-6.
26 Inhibition of human topoisomerase IIalpha by fluoroquinolones and ultraviolet A irradiation. Toxicol Sci. 2002 Sep;69(1):16-22.
27 Antitumor properties of podophyllotoxin and related compounds. Curr Pharm Des. 2000 Dec;6(18):1811-39.
28 Clinical pharmacokinetics of the newer antibacterial 4-quinolones. Clin Pharmacokinet. 1988 Feb;14(2):96-121.
29 Design of two etoposide-amsacrine conjugates: topoisomerase II and tubuline polymerization inhibition and relation to cytotoxicity. Anticancer Drug Des. 2000 Dec;15(6):413-21.
30 The role of bioreductive activation of doxorubicin in cytotoxic activity against leukaemia HL60-sensitive cell line and its multidrug-resistant sublines. Br J Cancer. 2005 Jul 11;93(1):89-97.
31 Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport. Cancer Res. 2001 Oct 1;61(19):7225-32.
32 Folate concentration dependent transport activity of the Multidrug Resistance Protein 1 (ABCC1). Biochem Pharmacol. 2004 Apr 15;67(8):1541-8.
33 Hammerhead ribozyme against gamma-glutamylcysteine synthetase sensitizes human colonic cancer cells to cisplatin by down-regulating both the glutathione synthesis and the expression of multidrug resistance proteins. Cancer Gene Ther. 2001 Oct;8(10):803-14.
34 Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
35 ATP-Dependent efflux of CPT-11 and SN-38 by the multidrug resistance protein (MRP) and its inhibition by PAK-104P. Mol Pharmacol. 1999 May;55(5):921-8.
36 Structural determinants of substrate specificity differences between human multidrug resistance protein (MRP) 1 (ABCC1) and MRP3 (ABCC3). Drug Metab Dispos. 2008 Dec;36(12):2571-81.
37 Evaluation of transport of common antiepileptic drugs by human multidrug resistance-associated proteins (MRP1, 2 and 5) that are overexpressed in pharmacoresistant epilepsy. Neuropharmacology. 2010 Jun;58(7):1019-32.
38 Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export. Br J Cancer. 2000 Aug;83(3):375-83.
39 Involvement of the drug transporters p glycoprotein and multidrug resistance-associated protein Mrp2 in telithromycin transport. Antimicrob Agents Chemother. 2006 Jan;50(1):80-7.
40 Dose-dependent disposition of methotrexate in Abcc2 and Abcc3 gene knockout murine models. Drug Metab Dispos. 2011 Nov;39(11):2155-61.
41 Mammalian multidrug-resistance proteins (MRPs). Essays Biochem. 2011 Sep 7;50(1):179-207.
42 Enhancing chemosensitivity in oral squamous cell carcinoma by lentivirus vector-mediated RNA interference targeting EGFR and MRP2. Oncol Lett. 2016 Sep;12(3):2107-2114.
43 Multidrug resistance associated protein 2 mediates transport of prostaglandin E2. Liver Int. 2006 Apr;26(3):362-8.
44 Lentivirus-mediated RNAi silencing targeting ABCC2 increasing the sensitivity of a human nasopharyngeal carcinoma cell line against cisplatin. J Transl Med. 2008 Oct 4;6:55.
45 Effect of acetaminophen on expression and activity of rat liver multidrug resistance-associated protein 2 and P-glycoprotein. Biochem Pharmacol. 2004 Aug 15;68(4):791-8.
46 Small intestinal efflux mediated by MRP2 and BCRP shifts sulfasalazine intestinal permeability from high to low, enabling its colonic targeting. Am J Physiol Gastrointest Liver Physiol. 2009 Aug;297(2):G371-7.
47 Multidrug Resistance-Associated Protein 2 (MRP2) Mediated Transport of Oxaliplatin-Derived Platinum in Membrane Vesicles. PLoS One. 2015 Jul 1;10(7):e0130727.
48 Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
49 MDR1 (ABCB1) G1199A (Ser400Asn) polymorphism alters transepithelial permeability and sensitivity to anticancer agents. Cancer Chemother Pharmacol. 2009 Jun;64(1):183-8.
50 Folate transporter expression decreases in the human placenta throughout pregnancy and in pre-eclampsia. Pregnancy Hypertens. 2012 Apr;2(2):123-31.
51 Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8.
52 Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92.
53 Association of genetic polymorphisms in the influx transporter SLCO1B3 and the efflux transporter ABCB1 with imatinib pharmacokinetics in patients with chronic myeloid leukemia. Ther Drug Monit. 2011 Apr;33(2):244-50.
54 Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer. Int J Oncol. 2007 Mar;30(3):717-25.
55 Wild-type breast cancer resistance protein (BCRP/ABCG2) is a methotrexate polyglutamate transporter. Cancer Res. 2003 Sep 1;63(17):5538-43.
56 The effect of low pH on breast cancer resistance protein (ABCG2)-mediated transport of methotrexate, 7-hydroxymethotrexate, methotrexate diglutamate, folic acid, mitoxantrone, topotecan, and resveratrol in in vitro drug transport models. Mol Pharmacol. 2007 Jan;71(1):240-9.
57 Role of BCRP as a biomarker for predicting resistance to 5-fluorouracil in breast cancer. Cancer Chemother Pharmacol. 2009 May;63(6):1103-10.
58 Inhibiting the function of ABCB1 and ABCG2 by the EGFR tyrosine kinase inhibitor AG1478. Biochem Pharmacol. 2009 Mar 1;77(5):781-93.
59 Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis. J Biol Chem. 2003 Jun 6;278(23):20645-51.
60 The phytoestrogen genistein enhances multidrug resistance in breast cancer cell lines by translational regulation of ABC transporters. Cancer Lett. 2016 Jun 28;376(1):165-72.
61 Curcumin inhibits the activity of ABCG2/BCRP1, a multidrug resistance-linked ABC drug transporter in mice. Pharm Res. 2009 Feb;26(2):480-7.
62 Imatinib mesylate (STI571) is a substrate for the breast cancer resistance protein (BCRP)/ABCG2 drug pump. Blood. 2004 Nov 1;104(9):2940-2.
63 Preclinical Mouse Models To Study Human OATP1B1- and OATP1B3-Mediated Drug-Drug Interactions in Vivo. Mol Pharm. 2015 Dec 7;12(12):4259-69.
64 Organic anion transporting polypeptide 1B1: a genetically polymorphic transporter of major importance for hepatic drug uptake. Pharmacol Rev. 2011 Mar;63(1):157-81.
65 Contribution of OATP1B1 and OATP1B3 to the disposition of sorafenib and sorafenib-glucuronide. Clin Cancer Res. 2013 Mar 15;19(6):1458-66.
66 The effect of SLCO1B1*15 on the disposition of pravastatin and pitavastatin is substrate dependent: the contribution of transporting activity changes by SLCO1B1*15. Pharmacogenet Genomics. 2008 May;18(5):424-33.
67 Influence of SLCO1B1, 1B3, 2B1 and ABCC2 genetic polymorphisms on mycophenolic acid pharmacokinetics in Japanese renal transplant recipients. Eur J Clin Pharmacol. 2007 Dec;63(12):1161-9.
68 Rifampicin alters atorvastatin plasma concentration on the basis of SLCO1B1 521T>C polymorphism. Clin Chim Acta. 2009 Jul;405(1-2):49-52.
69 FDA Drug Development and Drug Interactions
70 Involvement of multiple transporters in the hepatobiliary transport of rosuvastatin. Drug Metab Dispos. 2008 Oct;36(10):2014-23.
71 Multidrug resistance protein (MRP) 1 and MRP3 attenuate cytotoxic and transactivating effects of the cyclopentenone prostaglandin, 15-deoxy-Delta(12,14)prostaglandin J2 in MCF7 breast cancer cells. Biochemistry. 2003 May 13;42(18):5429-37.
72 ATP-binding cassette C transporters in human pancreatic carcinoma cell lines. Upregulation in 5-fluorouracil-resistant cells. Pancreatology. 2009;9(1-2):136-44.
73 Complex pharmacokinetic behavior of ezetimibe depends on abcc2, abcc3, and abcg2. Drug Metab Dispos. 2009 Aug;37(8):1698-702.
74 Transport of glyburide by placental ABC transporters: implications in fetal drug exposure. Placenta. 2006 Nov-Dec;27(11-12):1096-102.
75 Multidrug resistance-associated proteins 3, 4, and 5. Pflugers Arch. 2007 Feb;453(5):661-73.
76 Oral availability of cefadroxil depends on ABCC3 and ABCC4. Drug Metab Dispos. 2012 Mar;40(3):515-21.
77 Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3). J Biol Chem. 2001 Dec 7;276(49):46400-7.
78 Involvement of multiple efflux transporters in hepatic disposition of fexofenadine. Mol Pharmacol. 2008 May;73(5):1474-83.
79 Induction of multiple drug transporters by efavirenz. J Pharmacol Sci. 2009 Feb;109(2):242-50.
80 LST-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. Gastroenterology. 2001 Jun;120(7):1689-99.
81 Influence of non-steroidal anti-inflammatory drugs on organic anion transporting polypeptide (OATP) 1B1- and OATP1B3-mediated drug transport. Drug Metab Dispos. 2011 Jun;39(6):1047-53.
82 Relevance of conserved lysine and arginine residues in transmembrane helices for the transport activity of organic anion transporting polypeptide 1B3. Br J Pharmacol. 2010 Feb 1;159(3):698-708.
83 Impact of OATP transporters on pharmacokinetics. Br J Pharmacol. 2009 Oct;158(3):693-705.
84 Contribution of OATP2 (OATP1B1) and OATP8 (OATP1B3) to the hepatic uptake of pitavastatin in humans. J Pharmacol Exp Ther. 2004 Oct;311(1):139-46.
85 Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun. 2000 Jun 24;273(1):251-60.
86 The Transporter Classification Database (TCDB): recent advances. Nucleic Acids Res. 2016 Jan 4;44(D1):D372-9. (ID: 2.A.60.1.20)
87 Small-Dosing Clinical Study: Pharmacokinetic, Pharmacogenomic (SLCO2B1 and ABCG2), and Interaction (Atorvastatin and Grapefruit Juice) Profiles of 5 Probes for OATP2B1 and BCRP. J Pharm Sci. 2017 Sep;106(9):2688-2694.
88 Functional characterization of pH-sensitive organic anion transporting polypeptide OATP-B in human. J Pharmacol Exp Ther. 2004 Feb;308(2):438-45.
89 Human platelets express organic anion-transporting peptide 2B1, an uptake transporter for atorvastatin. Drug Metab Dispos. 2009 May;37(5):1129-37.
90 pH-sensitive interaction of HMG-CoA reductase inhibitors (statins) with organic anion transporting polypeptide 2B1. Mol Pharm. 2011 Aug 1;8(4):1303-13.
91 Drug-drug interaction between pitavastatin and various drugs via OATP1B1. Drug Metab Dispos. 2006 Jul;34(7):1229-36.
92 Drug Interactions in Infectious Diseases.
93 Substrate-dependent drug-drug interactions between gemfibrozil, fluvastatin and other organic anion-transporting peptide (OATP) substrates on OATP1B1, OATP2B1, and OATP1B3. Drug Metab Dispos. 2007 Aug;35(8):1308-14.
94 Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines. Cancer. 2007 Mar 1;109(5):957-65.
95 Contribution of human hepatic cytochrome P450 isoforms to regioselective hydroxylation of steroid hormones. Xenobiotica. 1998 Jun;28(6):539-47.
96 Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6. J Pharmacol Exp Ther. 2004 Sep;310(3):1062-75.
97 Isoform-specific regulation of cytochromes P450 expression by estradiol and progesterone. Drug Metab Dispos. 2013 Feb;41(2):263-9.
98 Metabolic interactions between acetaminophen (paracetamol) and two flavonoids, luteolin and quercetin, through in-vitro inhibition studies. J Pharm Pharmacol. 2017 Dec;69(12):1762-1772.
99 Potent mechanism-based inhibition of CYP3A4 by imatinib explains its liability to interact with CYP3A4 substrates. Br J Pharmacol. 2012 Apr;165(8):2787-98.
100 The metabolism of zidovudine by human liver microsomes in vitro: formation of 3'-amino-3'-deoxythymidine. Biochem Pharmacol. 1994 Jul 19;48(2):267-76.
101 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
102 Cytochrome P450 3A4-mediated interaction of diclofenac and quinidine. Drug Metab Dispos. 2000 Sep;28(9):1043-50.
103 Roles of cytochromes P450 1A2, 2A6, and 2C8 in 5-fluorouracil formation from tegafur, an anticancer prodrug, in human liver microsomes. Drug Metab Dispos. 2000 Dec;28(12):1457-63.
104 Effects of polyunsaturated fatty acids on prostaglandin synthesis and cyclooxygenase-mediated DNA adduct formation by heterocyclic aromatic amines in human adenocarcinoma colon cells. Mol Carcinog. 2004 Jul;40(3):180-8.
105 Endoxifen and other metabolites of tamoxifen inhibit human hydroxysteroid sulfotransferase 2A1 (hSULT2A1). Drug Metab Dispos. 2014 Nov;42(11):1843-50.
106 Cytochrome P450 1A2 (CYP1A2) activity and risk factors for breast cancer: a cross-sectional study. Breast Cancer Res. 2004;6(4):R352-65.
107 PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses. Pharmacogenet Genomics. 2015 Aug;25(8):416-26.
108 The effect of apigenin on pharmacokinetics of imatinib and its metabolite N-desmethyl imatinib in rats. Biomed Res Int. 2013;2013:789184.
109 The influence of metabolic gene polymorphisms on urinary 1-hydroxypyrene concentrations in Chinese coke oven workers. Sci Total Environ. 2007 Aug 1;381(1-3):38-46.
110 Identification of P450 enzymes involved in metabolism of verapamil in humans. Naunyn Schmiedebergs Arch Pharmacol. 1993 Sep;348(3):332-7.
111 Metabolism and metabolic inhibition of xanthotoxol in human liver microsomes. Evid Based Complement Alternat Med. 2016;2016:5416509.
112 Ontogeny and sorafenib metabolism. Clin Cancer Res. 2012 Oct 15;18(20):5788-95.
113 Functional significance of UDP-glucuronosyltransferase variants in the metabolism of active tamoxifen metabolites. Cancer Res. 2009 Mar 1;69(5):1892-900.
114 Functional characterization of human and cynomolgus monkey UDP-glucuronosyltransferase 1A1 enzymes. Life Sci. 2010 Aug 14;87(7-8):261-8.
115 Effect of UDP-glucuronosyltransferase (UGT) 1A polymorphism (rs8330 and rs10929303) on glucuronidation status of acetaminophen. Dose Response. 2017 Sep 11;15(3):1559325817723731.
116 Interindividual variability in pharmacokinetics of generic nucleoside reverse transcriptase inhibitors in TB/HIV-coinfected Ghanaian patients: UGT2B7*1c is associated with faster zidovudine clearance and glucuronidation. J Clin Pharmacol. 2009 Sep;49(9):1079-90.
117 Effect of aging on glucuronidation of valproic acid in human liver microsomes and the role of UDP-glucuronosyltransferase UGT1A4, UGT1A8, and UGT1A10. Drug Metab Dispos. 2009 Jan;37(1):229-36.
118 Characterization of rat intestinal microsomal UDP-glucuronosyltransferase activity toward mycophenolic acid. Drug Metab Dispos. 2006 Sep;34(9):1632-9.
119 Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios. Drug Metab Dispos. 2004 Nov;32(11):1201-8.
120 Substrate-dependent modulation of UDP-glucuronosyltransferase 1A1 (UGT1A1) by propofol in recombinant human UGT1A1 and human liver microsomes. Basic Clin Pharmacol Toxicol. 2007 Sep;101(3):211-4.
121 Identification and preliminary characterization of UDP-glucuronosyltransferases catalyzing formation of ethyl glucuronide. Anal Bioanal Chem. 2014 Apr;406(9-10):2325-32.
122 Atorvastatin glucuronidation is minimally and nonselectively inhibited by the fibrates gemfibrozil, fenofibrate, and fenofibric acid. Drug Metab Dispos. 2007 Aug;35(8):1315-24.
123 Drug related genetic polymorphisms affecting adverse reactions to methotrexate, vinblastine, doxorubicin and cisplatin in patients with urothelial cancer. J Urol. 2008 Dec;180(6):2389-95.
124 Human prostate CYP3A5: identification of a unique 5'-untranslated sequence and characterization of purified recombinant protein. Biochem Biophys Res Commun. 1999 Jul 14;260(3):676-81.
125 Polymorphisms in cytochrome P4503A5 (CYP3A5) may be associated with race and tumor characteristics, but not metabolism and side effects of tamoxifen in breast cancer patients. Cancer Lett. 2005 Jan 10;217(1):61-72.
126 Drug Interactions Flockhart Table
127 Induction of hepatic CYP2E1 by a subtoxic dose of acetaminophen in rats: increase in dichloromethane metabolism and carboxyhemoglobin elevation. Drug Metab Dispos. 2007 Oct;35(10):1754-8.
128 Urinary 6 beta-hydroxycortisol excretion in rheumatoid arthritis. Br J Rheumatol. 1997 Jan;36(1):54-8.
129 Clinical pharmacokinetics of imatinib. Clin Pharmacokinet. 2005;44(9):879-94.
130 Differential mechanism-based inhibition of CYP3A4 and CYP3A5 by verapamil. Drug Metab Dispos. 2005 May;33(5):664-71.
131 16Alpha-hydroxylation of estrone by human cytochrome P4503A4/5. Carcinogenesis. 1998 May;19(5):867-72.
132 Chronic ethanol feeding and folate deficiency activate hepatic endoplasmic reticulum stress pathway in micropigs. Am J Physiol Gastrointest Liver Physiol. 2005 Jul;289(1):G54-63.
133 Cytochrome P450 2E1 null mice provide novel protection against cisplatin-induced nephrotoxicity and apoptosis. Kidney Int. 2003 May;63(5):1687-96.
134 Genotoxicity of tamoxifen, tamoxifen epoxide and toremifene in human lymphoblastoid cells containing human cytochrome P450s. Carcinogenesis. 1994 Jan;15(1):5-9.
135 Acetaminophen induced acute liver failure via oxidative stress and JNK activation: protective role of taurine by the suppression of cytochrome P450 2E1. Free Radic Res. 2010 Mar;44(3):340-55.
136 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
137 Novel metabolic pathway of estrone and 17beta-estradiol catalyzed by cytochrome P-450. Drug Metab Dispos. 2000 Feb;28(2):110-2.
138 Inhibition of cytochrome P450 2E1 by propofol in human and porcine liver microsomes. Biochem Pharmacol. 2002 Oct 1;64(7):1151-6.
139 CYP2E1 and clinical features in alcoholics. Neuropsychobiology. 2003;47(2):86-9.
140 Effects of nicotine on cytochrome P450 2A6 and 2E1 activities. Br J Clin Pharmacol. 2010 Feb;69(2):152-9.
141 Glutathione S-transferase genetic polymorphisms and individual sensitivity to the ototoxic effect of cisplatin. Anticancer Drugs. 2000 Sep;11(8):639-43.
142 PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA150642262)
143 Busulfan conjugation by glutathione S-transferases alpha, mu, and pi. Drug Metab Dispos. 1996 Sep;24(9):1015-9.
144 The anti-cancer drug chlorambucil as a substrate for the human polymorphic enzyme glutathione transferase P1-1: kinetic properties and crystallographic characterisation of allelic variants. J Mol Biol. 2008 Jun 27;380(1):131-44.
145 Divergent cyclooxygenase responses to fatty acid structure and peroxide level in fish and mammalian prostaglandin H synthases. FASEB J. 2006 Jun;20(8):1097-108.
146 Structural basis of fatty acid substrate binding to cyclooxygenase-2. J Biol Chem. 2010 Jul 16;285(29):22152-63.
147 Health implications of high dietary omega-6 polyunsaturated Fatty acids. J Nutr Metab. 2012;2012:539426.
148 PharmGKB summary: very important pharmacogene information for PTGS2. Pharmacogenet Genomics. 2011 Sep;21(9):607-13.
149 Docosahexaenoic acid regulates gene expression in HUVEC cells treated with polycyclic aromatic hydrocarbons. Toxicol Lett. 2015 Jul 16;236(2):75-81.
150 Conjugated linoleic acid, unlike other unsaturated fatty acids, strongly induces glutathione synthesis without any lipoperoxidation. Br J Nutr. 2006 Nov;96(5):811-9.
151 COX-2 and PPAR-gama confer cannabidiol-induced apoptosis of human lung cancer cells. Mol Cancer Ther. 2013 Jan;12(1):69-82.
152 Mitochondrial involvement in schizophrenia and other functional psychoses. Neurochem Res. 1996 Sep;21(9):995-1004.
153 Immunomodulatory effect of selective serotonin reuptake inhibitors (SSRIs) on human T lymphocyte function and gene expression. Eur Neuropsychopharmacol. 2007 Dec;17(12):774-80.
154 Stimulation of cyclooxygenase-2 expression by bone-derived transforming growth factor-beta enhances bone metastases in breast cancer. Cancer Res. 2006 Feb 15;66(4):2067-73.
155 Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
156 An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
157 A2E selectively induces cox-2 in ARPE-19 and human neural cells. Curr Eye Res. 2006 Mar;31(3):259-63.
158 Pharmacodynamic of cyclooxygenase inhibitors in humans. Prostaglandins Other Lipid Mediat. 2007 Jan;82(1-4):85-94.
159 The relative role of CYP3A4 and CYP3A5 in eplerenone metabolism. Toxicol Lett. 2019 Oct 15;315:9-13.
160 Characterization of the structural determinants required for potent mechanism-based inhibition of human cytochrome P450 1A1 by cannabidiol. Chem Biol Interact. 2014 May 25;215:62-8.
161 Retinoids activate the RXR/SXR-mediated pathway and induce the endogenous CYP3A4 activity in Huh7 human hepatoma cells. Toxicol Sci. 2006 Jul;92(1):51-60.
162 The novel azole R126638 is a selective inhibitor of ergosterol synthesis in Candida albicans, Trichophyton spp., and Microsporum canis. Antimicrob Agents Chemother. 2004 Sep;48(9):3272-8.
163 Application of higher throughput screening (HTS) inhibition assays to evaluate the interaction of antiparasitic drugs with cytochrome P450s. Drug Metab Dispos. 2001 Jan;29(1):30-5.
164 Cetirizine and loratadine-based antihistamines with 5-lipoxygenase inhibitory activity. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5591-4.
165 Mechanism-based inactivation of CYP3A by HIV protease inhibitors. J Pharmacol Exp Ther. 2005 Feb;312(2):583-91.
166 Studies of the toxicological potential of capsinoids, XIII: inhibitory effects of capsaicin and capsinoids on cytochrome P450 3A4 in human liver microsomes. Int J Toxicol. 2010 Mar;29(2 Suppl):22S-6S.
167 Investigation of the effects of axitinib on the pharmacokinetics of loperamide and its main metabolite N-demethylated loperamide in rats by UPLC-MS/MS. Chem Biol Interact. 2019 Sep 1;310:108744. doi: 10.1016/j.cbi.2019.108744. Epub 2019 Jul 9.
168 In vitro inhibition of CYP1A2 by model inhibitors, anti-inflammatory analgesics and female sex steroids: predictability of in vivo interactions. Basic Clin Pharmacol Toxicol. 2008 Aug;103(2):157-65.
169 Effects of capsaicin and dihydrocapsaicin on human and rat liver microsomal CYP450 enzyme activities in vitro and in vivo. J Asian Nat Prod Res. 2012;14(4):382-95.
170 Drug interaction study of flavonoids toward CYP3A4 and their quantitative structure activity relationship (QSAR) analysis for predicting potential effects. Toxicol Lett. 2018 Sep 15;294:27-36.
171 Stiripentol. Expert Opin Investig Drugs. 2005 Jul;14(7):905-11.
172 Inhibition of human cytochrome P450 enzymes by 1,4-dihydropyridine calcium antagonists: prediction of in vivo drug-drug interactions. Eur J Clin Pharmacol. 2000 Feb-Mar;55(11-12):843-52.
173 Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor. Drug Metab Dispos. 2003 Nov;31(11):1352-60.
174 Predictive three-dimensional quantitative structure-activity relationship of cytochrome P450 1A2 inhibitors. J Med Chem. 2005 Jun 2;48(11):3808-15.
175 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
176 Contribution of CYP3A5 to hepatic and renal ifosfamide N-dechloroethylation. Drug Metab Dispos. 2005 Jul;33(7):1074-81. doi: 10.1124/dmd.104.002279. Epub 2005 Apr 8.
177 Use of mRNA expression to detect the induction of drug metabolising enzymes in rat and human hepatocytes. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):86-96.
178 Induction of human cytochrome P450 3A enzymes in cultured placental cells by thalidomide and relevance to bioactivation and toxicity. J Toxicol Sci. 2017;42(3):343-348.
179 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
180 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
181 Induction of hepatic CYP3A enzymes by pregnancy-related hormones: studies in human hepatocytes and hepatic cell lines. Drug Metab Dispos. 2013 Feb;41(2):281-90.
182 Influence of glutathione S-transferase A1, P1, M1, T1 polymorphisms on oral busulfan pharmacokinetics in children with congenital hemoglobinopathies undergoing hematopoietic stem cell transplantation. Pediatr Blood Cancer. 2010 Dec 1;55(6):1172-9. doi: 10.1002/pbc.22739.
183 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
184 The influence of coordinate overexpression of glutathione phase II detoxification gene products on drug resistance. J Pharmacol Exp Ther. 2000 Aug;294(2):480-7.
185 Cell-type-specific responses to chemotherapeutics in breast cancer. Cancer Res. 2004 Jun 15;64(12):4218-26.
186 Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Redox Biol. 2020 Jan;28:101321. doi: 10.1016/j.redox.2019.101321. Epub 2019 Sep 5.
187 Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
188 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
189 Consequences of the natural retinoid/retinoid X receptor ligands action in human breast cancer MDA-MB-231 cell line: Focus on functional proteomics. Toxicol Lett. 2017 Nov 5;281:26-34. doi: 10.1016/j.toxlet.2017.09.001. Epub 2017 Sep 5.
190 Glutathione S-transferase pi as a target for tricyclic antidepressants in human brain. Acta Biochim Pol. 2004;51(1):207-12.
191 Single and concerted effects of benzo[a]pyrene and flavonoids on the AhR and Nrf2-pathway in the human colon carcinoma cell line Caco-2. Toxicol In Vitro. 2011 Apr;25(3):671-83.
192 Characteristics of P388/VMDRC.04, a simple, sensitive model for studying P-glycoprotein antagonists. Cancer Res. 1994 Feb 1;54(3):730-7.
193 Michaelis-Menten kinetic analysis of drugs of abuse to estimate their affinity to human P-glycoprotein. Toxicol Lett. 2013 Feb 27;217(2):137-42. doi: 10.1016/j.toxlet.2012.12.012. Epub 2012 Dec 27.
194 Editor's Highlight: PlacentalDisposition and Effects of Crizotinib: An Ex Vivo Study in the Isolated Dual-Side Perfused Human Cotyledon. Toxicol Sci. 2017 Jun 1;157(2):500-509. doi: 10.1093/toxsci/kfx063.
195 Functional evaluation of polymorphisms in the human ABCB1 gene and the impact on clinical responses of antiepileptic drugs. Pharmacogenet Genomics. 2008 May;18(5):390-402. doi: 10.1097/FPC.0b013e3282f85e36.
196 Cepharanthine potently enhances the sensitivity of anticancer agents in K562 cells. Cancer Sci. 2005 Jun;96(6):372-6. doi: 10.1111/j.1349-7006.2005.00057.x.
197 Clinical pharmacokinetic monitoring of itraconazole is warranted in only a subset of patients. Ther Drug Monit. 2005 Jun;27(3):322-33. doi: 10.1097/01.ftd.0000150135.22645.ea.
198 Evaluation of antipsychotic drugs as inhibitors of multidrug resistance transporter P-glycoprotein. Psychopharmacology (Berl). 2006 Sep;187(4):415-23. doi: 10.1007/s00213-006-0437-9. Epub 2006 Jun 30.
199 Actions of the selective protein kinase C inhibitor PKC412 on B-chronic lymphocytic leukemia cells in vitro. Haematologica. 2002 Feb;87(2):167-76.
200 Characterization of the ATPase activity of the Mr 170,000 to 180,000 membrane glycoprotein (P-glycoprotein) associated with multidrug resistance in K562/ADM cells. Cancer Res. 1988 Sep 1;48(17):4926-32.
201 Evaluation of drug transporters' significance for multidrug resistance in head and neck squamous cell carcinoma. Head Neck. 2011 Jul;33(7):959-68. doi: 10.1002/hed.21559. Epub 2010 Aug 24.
202 Gene expression profiling of leukemia T-cells resistant to methotrexate and 7-hydroxymethotrexate reveals alterations that preserve intracellular levels of folate and nucleotide biosynthesis. Biochem Pharmacol. 2009 Apr 15;77(8):1410-7.
203 Adaptive homeostasis of the vitamin D-vitamin D nuclear receptor axis in 8-methoxypsoralen-induced hepatotoxicity. Toxicol Appl Pharmacol. 2019 Jan 1;362:150-158. doi: 10.1016/j.taap.2018.11.002. Epub 2018 Nov 10.
204 Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
205 Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
206 Differential regulation of the human MRP2 and MRP3 gene expression by glucocorticoids. J Steroid Biochem Mol Biol. 2005 Aug;96(3-4):229-34. doi: 10.1016/j.jsbmb.2005.03.004.
207 Induction of multidrug resistance proteins MRP1 and MRP3 and gamma-glutamylcysteine synthetase gene expression by nonsteroidal anti-inflammatory drugs in human colon cancer cells. Biochem Biophys Res Commun. 2002 Feb 8;290(5):1427-33. doi: 10.1006/bbrc.2002.6367.
208 Activation of nuclear factor-kappa B pathway by simvastatin and RhoA silencing increases doxorubicin cytotoxicity in human colon cancer HT29 cells. Mol Pharmacol. 2008 Aug;74(2):476-84.
209 Potency of individual bile acids to regulate bile acid synthesis and transport genes in primary human hepatocyte cultures. Toxicol Sci. 2014 Oct;141(2):538-46. doi: 10.1093/toxsci/kfu151. Epub 2014 Jul 23.
210 Characterization of multidrug transporter-mediated efflux of avermectins in human and mouse neuroblastoma cell lines. Toxicol Lett. 2015 Jun 15;235(3):189-98. doi: 10.1016/j.toxlet.2015.04.005. Epub 2015 Apr 9.
211 Methotrexate normalizes up-regulated folate pathway genes in rheumatoid arthritis. Arthritis Rheum. 2013 Nov;65(11):2791-802.
212 Influence of redox-active compounds and PXR-activators on human MRP1 and MRP2 gene expression. Toxicology. 2002 Feb 28;171(2-3):137-46.
213 Enhanced in vitro invasiveness and drug resistance with altered gene expression patterns in a human lung carcinoma cell line after pulse selection with anticancer drugs. Int J Cancer. 2004 Sep 10;111(4):484-93. doi: 10.1002/ijc.20230.
214 Clinical determinants of response to irinotecan-based therapy derived from cell line models. Clin Cancer Res. 2008 Oct 15;14(20):6647-55.
215 Co-encapsulation of chrysophsin-1 and epirubicin in PEGylated liposomes circumvents multidrug resistance in HeLa cells. Chem Biol Interact. 2015 Dec 5;242:13-23. doi: 10.1016/j.cbi.2015.08.023. Epub 2015 Sep 1.
216 Upregulation of multi drug resistance genes in doxorubicin resistant human acute myelogeneous leukemia cells and reversal of the resistance. Hematology. 2007 Dec;12(6):511-7. doi: 10.1080/10245330701562535.
217 Functional analysis of MRP1 cloned from bovine. FEBS Lett. 2002 Jun 19;521(1-3):211-3. doi: 10.1016/s0014-5793(02)02816-8.
218 Functional defect caused by the 4544G>A SNP in ABCC2: potential impact for drug cellular disposition. Pharmacogenet Genomics. 2011 Dec;21(12):884-93. doi: 10.1097/FPC.0b013e32834d672b.
219 Role of multidrug resistance protein 2 (MRP2, ABCC2) in alkylating agent detoxification: MRP2 potentiates glutathione S-transferase A1-1-mediated resistance to chlorambucil cytotoxicity. J Pharmacol Exp Ther. 2004 Jan;308(1):260-7. doi: 10.1124/jpet.103.057729. Epub 2003 Oct 20.
220 MRP2 (ABCC2) transports taxanes and confers paclitaxel resistance and both processes are stimulated by probenecid. Int J Cancer. 2005 Sep 20;116(5):824-9. doi: 10.1002/ijc.21013.
221 Association of genetic polymorphisms in SLCO1B3 and ABCC2 with docetaxel-induced leukopenia. Cancer Sci. 2008 May;99(5):967-72.
222 In vitro study of transporters involved in intestinal absorption of inorganic arsenic. Chem Res Toxicol. 2012 Feb 20;25(2):446-53. doi: 10.1021/tx200491f. Epub 2012 Jan 26.
223 Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
224 HU-331 and Oxidized Cannabidiol Act as Inhibitors of Human Topoisomerase II and . Chem Res Toxicol. 2018 Feb 19;31(2):137-144. doi: 10.1021/acs.chemrestox.7b00302. Epub 2018 Jan 8.
225 Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res. 2002 Aug 1;62(15):4419-26.
226 Interactions between the etoposide derivative F14512 and human type II topoisomerases: implications for the C4 spermine moiety in promoting enzyme-mediated DNA cleavage. Biochemistry. 2011 Apr 19;50(15):3240-9. doi: 10.1021/bi200094z. Epub 2011 Mar 28.
227 Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells. Eur J Pharmacol. 2014 Jun 5;732:60-7.
228 The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib. Toxicol Sci. 2023 Dec 21;197(1):69-78. doi: 10.1093/toxsci/kfad099.
229 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
230 Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
231 Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
232 Arsenic trioxide exposure to ovarian carcinoma cells leads to decreased level of topoisomerase II and cytotoxicity. Int J Gynecol Cancer. 2006 Jul-Aug;16(4):1552-6. doi: 10.1111/j.1525-1438.2006.00626.x.
233 Trovafloxacin enhances lipopolysaccharide-stimulated production of tumor necrosis factor- by macrophages: role of the DNA damage response. J Pharmacol Exp Ther. 2014 Jul;350(1):164-70. doi: 10.1124/jpet.114.214189. Epub 2014 May 9.
234 Downregulation of mitogen-activated protein kinases (MAPKs) in chronic ethanol-induced fatty liver. Toxicol Mech Methods. 2020 Jul;30(6):407-416. doi: 10.1080/15376516.2020.1747126. Epub 2020 Apr 1.
235 Progesterone increases csk homologous kinase in HMC-1560 human mast cells and reduces cell proliferation. J Cell Biochem. 2007 Dec 1;102(5):1271-80. doi: 10.1002/jcb.21357.
236 A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16657-62. doi: 10.1073/pnas.0707936104. Epub 2007 Oct 9.
237 The stent-eluting drugs sirolimus and paclitaxel suppress healing of the endothelium by induction of autophagy. Am J Pathol. 2009 Nov;175(5):2226-34.
238 Treatment with anticancer agents induces dysregulation of specific Wnt signaling pathways in human ovarian luteinized granulosa cells in vitro. Toxicol Sci. 2013 Nov;136(1):183-92. doi: 10.1093/toxsci/kft175. Epub 2013 Aug 16.
239 Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
240 Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
241 Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2. Int J Cancer. 2006 Mar 15;118(6):1370-80. doi: 10.1002/ijc.21537.
242 Estrogen and pure antiestrogen fulvestrant (ICI 182 780) augment cell-matrigel adhesion of MCF-7 breast cancer cells through a novel G protein coupled estrogen receptor (GPR30)-to-calpain signaling axis. Toxicol Appl Pharmacol. 2014 Mar 1;275(2):176-81. doi: 10.1016/j.taap.2014.01.005. Epub 2014 Jan 17.
243 Different apoptosis ratios and gene expressions in two human cell lines after sevoflurane anaesthesia. Acta Anaesthesiol Scand. 2009 Oct;53(9):1192-9. doi: 10.1111/j.1399-6576.2009.02036.x. Epub 2009 Jun 30.
244 [Mechanisms underlying the effect of arsenic trioxide on proliferation inhibition and apoptosis induction in myeloma cell line u266]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2007 Oct;15(5):982-5.
245 Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPAR-dependent pathway. Oncotarget. 2016 Mar 1;7(9):10345-62. doi: 10.18632/oncotarget.7213.
246 Induction of apoptosis by cidofovir in human papillomavirus (HPV)-positive cells. Oncol Res. 2000;12(9-10):397-408. doi: 10.3727/096504001108747855.
247 Comparison of burst of reactive oxygen species and activation of caspase-3 in apoptosis of K562 and HL-60 cells induced by docetaxel. Cancer Lett. 2004 Oct 8;214(1):103-13. doi: 10.1016/j.canlet.2004.03.047.
248 Cisplatin-enhanced sensitivity of glioblastoma multiforme U251 cells to adenovirus-delivered TRAIL in vitro. Tumour Biol. 2010 Dec;31(6):613-22. doi: 10.1007/s13277-010-0077-x. Epub 2010 Jul 11.
249 Insulin-like growth factor I is the key growth factor in serum that protects neuroblastoma cells from hyperosmotic-induced apoptosis. J Cell Physiol. 2000 Jan;182(1):24-32. doi: 10.1002/(SICI)1097-4652(200001)182:1<24::AID-JCP3>3.0.CO;2-6.
250 mRNA expression analysis of a variety of apoptosis-related genes, including the novel gene of the BCL2-family, BCL2L12, in HL-60 leukemia cells after treatment with carboplatin and doxorubicin. Biol Chem. 2004 Nov;385(11):1099-103. doi: 10.1515/BC.2004.143.
251 Neurokinin-1 receptor (NK1R) inhibition sensitizes APL cells to anti-tumor effect of arsenic trioxide via restriction of NF-B axis: Shedding new light on resistance to Aprepitant. Int J Biochem Cell Biol. 2018 Oct;103:105-114. doi: 10.1016/j.biocel.2018.08.010. Epub 2018 Aug 23.
252 Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget. 2019 Jan 1;10(1):45-59. doi: 10.18632/oncotarget.26534. eCollection 2019 Jan 1.
253 4.8% sevoflurane induces activation of autophagy in human neuroblastoma SH-SY5Y cells by the AMPK/mTOR signaling pathway. Neurotoxicology. 2022 May;90:256-264. doi: 10.1016/j.neuro.2022.04.008. Epub 2022 Apr 23.
254 Enhanced chemotherapeutic efficacy of docetaxel in human lung cancer cell line via GLUT1 inhibitor. J Biochem Mol Toxicol. 2023 Jun;37(6):e23348. doi: 10.1002/jbt.23348. Epub 2023 Mar 31.
255 Breast cancer cells response to the antineoplastic agents cisplatin, carboplatin, and doxorubicin at the mRNA expression levels of distinct apoptosis-related genes, including the new member, BCL2L12. Ann N Y Acad Sci. 2007 Jan;1095:35-44. doi: 10.1196/annals.1397.005.
256 Extracellular signal-regulated kinase activation and Bcl-2 downregulation mediate apoptosis after gemcitabine treatment partly via a p53-independent pathway. Eur J Pharmacol. 2004 Oct 19;502(3):169-83. doi: 10.1016/j.ejphar.2004.09.006.
257 Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
258 Verapamil potentiates anti-glioblastoma efficacy of temozolomide by modulating apoptotic signaling. Toxicol In Vitro. 2018 Oct;52:306-313. doi: 10.1016/j.tiv.2018.07.001. Epub 2018 Jul 9.
259 Inhibition of caspase-dependent mitochondrial permeability transition protects airway epithelial cells against mustard-induced apoptosis. Apoptosis. 2006 Sep;11(9):1545-59. doi: 10.1007/s10495-006-8764-1.
260 -Carotene Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cell Lines via the Cav-1/AKT/NF-B Signaling Pathway. J Biochem Mol Toxicol. 2016 Mar;30(3):148-57. doi: 10.1002/jbt.21773. Epub 2016 Jan 6.
261 Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/ 5-fluorocytosine suicide gene therapy-induced cell death in glioma cells. Oncogene. 2005 Feb 10;24(7):1231-43. doi: 10.1038/sj.onc.1208290.
262 Statins activate the mitochondrial pathway of apoptosis in human lymphoblasts and myeloma cells. Carcinogenesis. 2005 May;26(5):883-91. doi: 10.1093/carcin/bgi036. Epub 2005 Feb 10.
263 Drug-induced caspase 8 upregulation sensitises cisplatin-resistant ovarian carcinoma cells to rhTRAIL-induced apoptosis. Br J Cancer. 2011 Apr 12;104(8):1278-87. doi: 10.1038/bjc.2011.84.
264 The anti-cancer drug gefitinib accelerates Fas-mediated apoptosis by enhancing caspase-8 activation in cancer cells. J Toxicol Sci. 2019;44(6):435-440. doi: 10.2131/jts.44.435.
265 Melatonin enhances hydrogen peroxide-induced apoptosis in human promyelocytic leukaemia HL-60 cells. Mol Cell Biochem. 2011 Jul;353(1-2):167-76. doi: 10.1007/s11010-011-0783-8. Epub 2011 Mar 23.
266 Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
267 Ciprofloxacin induces apoptosis and inhibits proliferation of human colorectal carcinoma cells. Br J Cancer. 2002 Feb 1;86(3):443-8. doi: 10.1038/sj.bjc.6600079.
268 The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
269 Response rate of fibrosarcoma cells to cytotoxic drugs on the expression level correlates to the therapeutic response rate of fibrosarcomas and is mediated by regulation of apoptotic pathways. BMC Cancer. 2005 Jul 7;5:74. doi: 10.1186/1471-2407-5-74.
270 The role of RelA (p65) threonine 505 phosphorylation in the regulation of cell growth, survival, and migration. Mol Biol Cell. 2011 Sep;22(17):3032-40. doi: 10.1091/mbc.E11-04-0280. Epub 2011 Jul 7.
271 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
272 Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. Br J Dermatol. 2009 Mar;160(3):519-26. doi: 10.1111/j.1365-2133.2008.08931.x. Epub 2008 Nov 25.
273 Quercetin and Its Fermented Extract as a Potential Inhibitor of Bisphenol A-Exposed HT-29 Colon Cancer Cells' Viability. Int J Mol Sci. 2023 Mar 15;24(6):5604. doi: 10.3390/ijms24065604.
274 Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP, cIAP2, BCL-XL and survivin. Med Oncol. 2010 Sep;27(3):833-42. doi: 10.1007/s12032-009-9294-9. Epub 2009 Sep 10.
275 Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
276 Nuclear and Mitochondrial DNA Methylation Patterns Induced by Valproic Acid in Human Hepatocytes. Chem Res Toxicol. 2017 Oct 16;30(10):1847-1854. doi: 10.1021/acs.chemrestox.7b00171. Epub 2017 Sep 13.
277 Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
278 The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells. Leukemia. 2009 Jun;23(6):1019-28.
279 Effects of 25-hydroxyvitamin D(3) on proliferation and osteoblast differentiation of human marrow stromal cells require CYP27B1/1alpha-hydroxylase. J Bone Miner Res. 2011 May;26(5):1145-53.
280 Down-regulation by nuclear factor kappaB of human 25-hydroxyvitamin D3 1alpha-hydroxylase promoter. Mol Endocrinol. 2004 Oct;18(10):2440-50. doi: 10.1210/me.2002-0441. Epub 2004 Jul 8.
281 Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
282 Bone marrow osteoblast damage by chemotherapeutic agents. PLoS One. 2012;7(2):e30758. doi: 10.1371/journal.pone.0030758. Epub 2012 Feb 17.
283 Association of Arsenic Exposure with Whole Blood DNA Methylation: An Epigenome-Wide Study of Bangladeshi Adults. Environ Health Perspect. 2019 May;127(5):57011. doi: 10.1289/EHP3849. Epub 2019 May 28.
284 Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain. Toxicol Lett. 2015 Apr 16;234(2):139-50.
285 17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.
286 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
287 Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
288 Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
289 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
290 Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
291 Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
292 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
293 Chronic ethanol exposure increases goosecoid (GSC) expression in human embryonic carcinoma cell differentiation. J Appl Toxicol. 2014 Jan;34(1):66-75.
294 Various concentrations of hesperetin induce different types of programmed cell death in human breast cancerous and normal cell lines in a ROS-dependent manner. Chem Biol Interact. 2023 Sep 1;382:110642. doi: 10.1016/j.cbi.2023.110642. Epub 2023 Jul 23.
295 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
296 Quercetin inhibits invasion, migration and signalling molecules involved in cell survival and proliferation of prostate cancer cell line (PC-3). Cell Biochem Funct. 2011 Mar;29(2):87-95. doi: 10.1002/cbf.1725. Epub 2011 Feb 9.
297 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
298 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
299 Arsenic trioxide (As2O3) inhibits invasion of HT1080 human fibrosarcoma cells: role of nuclear factor-kappaB and reactive oxygen species. J Cell Biochem. 2005 Aug 1;95(5):955-69. doi: 10.1002/jcb.20452.
300 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
301 Atorvastatin affects several angiogenic mediators in human endothelial cells. Endothelium. 2005 Sep-Dec;12(5-6):233-41.
302 Acetaminophen-induced proliferation of estrogen-responsive breast cancer cells is associated with increases in c-myc RNA expression and NF-kappaB activity. Toxicol Sci. 2002 Apr;66(2):233-43. doi: 10.1093/toxsci/66.2.233.
303 Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
304 ZD1839 induces p15INK4b and causes G1 arrest by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway. Mol Cancer Ther. 2007 May;6(5):1579-87. doi: 10.1158/1535-7163.MCT-06-0814.
305 Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
306 Selenite and selenomethionine promote HL-60 cell cycle progression. J Nutr. 2002 Apr;132(4):674-9. doi: 10.1093/jn/132.4.674.
307 Ribavirin augments doxorubicin's efficacy in human hepatocellular carcinoma through inhibiting doxorubicin-induced eIF4E activation. J Biochem Mol Toxicol. 2018 Jan;32(1). doi: 10.1002/jbt.22007. Epub 2017 Nov 7.
308 Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner. Clin Cancer Res. 2012 Aug 15;18(16):4345-55. doi: 10.1158/1078-0432.CCR-11-3227. Epub 2012 Jun 25.
309 Novel detection and differential utilization of a c-myc transcriptional block in colon cancer chemoprevention. Cancer Res. 2002 Nov 1;62(21):6006-10.
310 Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
311 Pharmacogenomic analysis of acute promyelocytic leukemia cells highlights CYP26 cytochrome metabolism in differential all-trans retinoic acid sensitivity. Blood. 2007 May 15;109(10):4450-60.
312 Proteomic and functional analyses reveal a dual molecular mechanism underlying arsenic-induced apoptosis in human multiple myeloma cells. J Proteome Res. 2009 Jun;8(6):3006-19.
313 Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
314 White-to-brown metabolic conversion of human adipocytes by JAK inhibition. Nat Cell Biol. 2015 Jan;17(1):57-67. doi: 10.1038/ncb3075. Epub 2014 Dec 8.
315 Magnitude and time course of platelet inhibition with Aggrenox and Aspirin in patients after ischemic stroke: the AGgrenox versus Aspirin Therapy Evaluation (AGATE) trial. Eur J Pharmacol. 2004 Sep 24;499(3):315-24. doi: 10.1016/j.ejphar.2004.07.114.
316 Proteomic analysis of human adipose tissue after rosiglitazone treatment shows coordinated changes to promote glucose uptake. Obesity (Silver Spring). 2010 Jan;18(1):27-34. doi: 10.1038/oby.2009.208. Epub 2009 Jun 25.
317 Cholinergic drugs inhibit in?vitro megakaryopoiesis via the alpha7-nicotinic acetylcholine receptor. Platelets. 2011;22(5):390-5. doi: 10.3109/09537104.2010.551304. Epub 2011 Mar 9.
318 Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
319 Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
320 Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
321 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
322 Inhibiting Heat Shock Proteins Can Potentiate the Cytotoxic Effect of Cannabidiol in Human Glioma Cells. Anticancer Res. 2015 Nov;35(11):5827-37.
323 Identification of genes linked to gefitinib treatment in prostate cancer cell lines with or without resistance to androgen: a clue to application of gefitinib to hormone-resistant prostate cancer. Oncol Rep. 2006 Jun;15(6):1453-60.
324 Chromium III histidinate exposure modulates gene expression in HaCaT human keratinocytes exposed to oxidative stress. Biol Trace Elem Res. 2010 Oct;137(1):23-39.
325 Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
326 A dual role of p21waf1/cip1 gene in apoptosis of HEp-2 treated with cisplatin or methotrexate. Cancer Gene Ther. 2008 Sep;15(9):576-90. doi: 10.1038/cgt.2008.28. Epub 2008 May 16.
327 The Effect of GADD45a on Furazolidone-Induced S-Phase Cell-Cycle Arrest in Human Hepatoma G2 Cells. J Biochem Mol Toxicol. 2015 Oct;29(10):489-495. doi: 10.1002/jbt.21719. Epub 2015 Jun 11.
328 Signaling pathways involved in induction of GADD45 gene expression and apoptosis by troglitazone in human MCF-7 breast carcinoma cells. Oncogene. 2004 Jun 3;23(26):4614-23. doi: 10.1038/sj.onc.1207598.
329 Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
330 Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
331 Evaluation of developmental toxicity using undifferentiated human embryonic stem cells. J Appl Toxicol. 2015 Feb;35(2):205-18.
332 Biological effects and metabolism of 9-cis-retinoic acid and its metabolite 9,13-di-cis-retinoic acid in HaCaT keratinocytes in vitro: comparison with all-trans-retinoic acid. Arch Dermatol Res. 2000 Dec;292(12):612-20. doi: 10.1007/s004030000189.
333 Molecular targeting of retinoic acid metabolism in neuroblastoma: the role of the CYP26 inhibitor R116010 in vitro and in vivo. Br J Cancer. 2007 Jun 4;96(11):1675-83.
334 THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
335 Molecular and metabolic retinoid pathways in human amniotic membranes. Biochem Biophys Res Commun. 2006 Aug 11;346(4):1207-16. doi: 10.1016/j.bbrc.2006.06.024. Epub 2006 Jun 12.
336 Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer Sci. 2007 Jun;98(6):890-9.
337 The human receptor tyrosine kinase Axl gene--promoter characterization and regulation of constitutive expression by Sp1, Sp3 and CpG methylation. Biosci Rep. 2008 Jun;28(3):161-76. doi: 10.1042/BSR20080046.
338 Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
339 Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
340 Gene expression profiling of rheumatoid arthritis synovial cells treated with antirheumatic drugs. J Biomol Screen. 2007 Apr;12(3):328-40. doi: 10.1177/1087057107299261. Epub 2007 Mar 22.
341 Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2/M arrest and inducing apoptosis. Food Chem Toxicol. 2008 Jun;46(6):2042-53. doi: 10.1016/j.fct.2008.01.049. Epub 2008 Feb 7.
342 Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq. Arch Toxicol. 2018 Aug;92(8):2517-2531.
343 Hydroquinone increases 5-hydroxymethylcytosine formation through ten eleven translocation 1 (TET1) 5-methylcytosine dioxygenase. J Biol Chem. 2013 Oct 4;288(40):28792-800. doi: 10.1074/jbc.M113.491365. Epub 2013 Aug 12.
344 Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
345 Dissecting progressive stages of 5-fluorouracil resistance in vitro using RNA expression profiling. Int J Cancer. 2004 Nov 1;112(2):200-12. doi: 10.1002/ijc.20401.
346 Quantitative proteomics and transcriptomics addressing the estrogen receptor subtype-mediated effects in T47D breast cancer cells exposed to the phytoestrogen genistein. Mol Cell Proteomics. 2011 Jan;10(1):M110.002170.
347 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
348 Identification of novel low-dose bisphenol a targets in human foreskin fibroblast cells derived from hypospadias patients. PLoS One. 2012;7(5):e36711. doi: 10.1371/journal.pone.0036711. Epub 2012 May 4.
349 Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
350 Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029.
351 Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
352 Retinoic acid-induced downmodulation of telomerase activity in human cancer cells. Exp Mol Pathol. 2005 Oct;79(2):108-17.
353 Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
354 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
355 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
356 Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
357 Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. PLoS One. 2012;7(12):e53003. doi: 10.1371/journal.pone.0053003. Epub 2012 Dec 27.
358 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
359 Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
360 Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
361 Mapping genes that contribute to daunorubicin-induced cytotoxicity. Cancer Res. 2007 Jun 1;67(11):5425-33. doi: 10.1158/0008-5472.CAN-06-4431.
362 Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma. Oncotarget. 2014 May 15;5(9):2355-71.
363 Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
364 Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells. J Cell Biochem. 2006 Aug 1;98(5):1163-84.
365 A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo. Carcinogenesis. 2012 Jul;33(7):1421-9.
366 CXCL14 downregulation in human keratinocytes is a potential biomarker for a novel in vitro skin sensitization test. Toxicol Appl Pharmacol. 2020 Jan 1;386:114828. doi: 10.1016/j.taap.2019.114828. Epub 2019 Nov 14.
367 Mechanisms of indomethacin-induced alterations in the choline phospholipid metabolism of breast cancer cells. Neoplasia. 2006 Sep;8(9):758-71.
368 Effects of chlorpromazine with and without UV irradiation on gene expression of HepG2 cells. Mutat Res. 2005 Aug 4;575(1-2):47-60. doi: 10.1016/j.mrfmmm.2005.03.002. Epub 2005 Apr 26.
369 Arsenic trioxide induces different gene expression profiles of genes related to growth and apoptosis in glioma cells dependent on the p53 status. Mol Biol Rep. 2008 Sep;35(3):421-9.
370 Effects of aromatase inhibitors on human osteoblast and osteoblast-like cells: a possible androgenic bone protective effects induced by exemestane. Bone. 2007 Apr;40(4):876-87. doi: 10.1016/j.bone.2006.11.029. Epub 2006 Dec 28.
371 Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells. Carcinogenesis. 2006 May;27(5):916-24. doi: 10.1093/carcin/bgi312. Epub 2005 Dec 16.
372 Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis. Chem Res Toxicol. 2015 May 18;28(5):927-34. doi: 10.1021/tx5005248. Epub 2015 Apr 3.
373 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
374 Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Toxicol Appl Pharmacol. 2012 Jun 1;261(2):204-16.
375 Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92. doi: 10.1016/j.bbrc.2011.08.027. Epub 2011 Aug 16.
376 Cytosine arabinoside induces ectoderm and inhibits mesoderm expression in human embryonic stem cells during multilineage differentiation. Br J Pharmacol. 2011 Apr;162(8):1743-56.
377 Gene expression profile induced by BCNU in human glioma cell lines with differential MGMT expression. J Neurooncol. 2005 Jul;73(3):189-98.
378 Benzo[a]pyrene-induced changes in microRNA-mRNA networks. Chem Res Toxicol. 2012 Apr 16;25(4):838-49.
379 Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
380 Transcriptome profile analysis of saturated aliphatic aldehydes reveals carbon number-specific molecules involved in pulmonary toxicity. Chem Res Toxicol. 2014 Aug 18;27(8):1362-70.
381 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
382 Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium. Mol Hum Reprod. 2007 Sep;13(9):641-54.
383 The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
384 The RET oncogene is a critical component of transcriptional programs associated with retinoic acid-induced differentiation in neuroblastoma. Mol Cancer Ther. 2007 Apr;6(4):1300-9.
385 Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23. doi: 10.1007/s00204-013-1169-3. Epub 2013 Nov 30.
386 Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
387 Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
388 Integrated transcriptomic and metabolomic analyses to characterize the anti-cancer effects of (-)-epigallocatechin-3-gallate in human colon cancer cells. Toxicol Appl Pharmacol. 2020 Aug 15;401:115100. doi: 10.1016/j.taap.2020.115100. Epub 2020 Jun 6.
389 Functional cardiotoxicity assessment of cosmetic compounds using human-induced pluripotent stem cell-derived cardiomyocytes. Arch Toxicol. 2018 Jan;92(1):371-381.
390 Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
391 Both GLS silencing and GLS2 overexpression synergize with oxidative stress against proliferation of glioma cells. J Mol Med (Berl). 2014 Mar;92(3):277-90. doi: 10.1007/s00109-013-1105-2. Epub 2013 Nov 26.
392 Gypenosides protect retinal pigment epithelium cells from oxidative stress. Food Chem Toxicol. 2018 Feb;112:76-85.
393 Role of antioxidant systems in human androgen-independent prostate cancer cells. Prostate. 2000 May 1;43(2):144-9. doi: 10.1002/(sici)1097-0045(20000501)43:2<144::aid-pros9>3.0.co;2-h.
394 Cytotoxic Effects of Cannabinoids on Human HT-29 Colorectal Adenocarcinoma Cells: Different Mechanisms of THC, CBD, and CB83. Int J Mol Sci. 2020 Aug 1;21(15):5533. doi: 10.3390/ijms21155533.
395 Selenium deficiency alters epithelial cell morphology and responses to influenza. Free Radic Biol Med. 2007 Jun 15;42(12):1826-37.
396 Hepatocellular peroxisomes in human alcoholic and drug-induced hepatitis: a quantitative study. Hepatology. 1991 Nov;14(5):811-7.
397 Antioxidant enzyme and malondialdehyde values in social phobia before and after citalopram treatment. Eur Arch Psychiatry Clin Neurosci. 2004 Aug;254(4):231-5.
398 The effect of statins on lipids peroxidation and activities of antioxidants enzymes in patients with dyslipidemia. Przegl Lek. 2006;63(9):738-42.
399 Morphological and molecular course of mitochondrial pathology in cultured human cells exposed long-term to Zidovudine. Environ Mol Mutagen. 2007 Apr-May;48(3-4):179-89. doi: 10.1002/em.20245.
400 [Construction of subtracted cDNA library in human Jurkat T cell line induced by arsenic trioxide in vitro]. Zhonghua Yu Fang Yi Xue Za Zhi. 2003 Nov;37(6):403-7.
401 Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes. Toxicol Lett. 2018 Jun 1;289:1-13.
402 Inhibition of mitochondrial function in HL60 cells is associated with an increased apoptosis and expression of CD14. Biochem Biophys Res Commun. 1999 Sep 24;263(2):294-300. doi: 10.1006/bbrc.1999.1356.
403 Aberrant cell proliferation by enhanced mitochondrial biogenesis via mtTFA in arsenical skin cancers. Am J Pathol. 2011 May;178(5):2066-76.
404 Respiration and growth defects in transmitochondrial cell lines carrying the 11778 mutation associated with Leber's hereditary optic neuropathy. J Biol Chem. 1996 May 31;271(22):13155-61. doi: 10.1074/jbc.271.22.13155.
405 Development of an alternative zebrafish model for drug-induced intestinal toxicity. J Appl Toxicol. 2018 Feb;38(2):259-273. doi: 10.1002/jat.3520. Epub 2017 Oct 13.
406 The effects of quercetin in cultured human RPE cells under oxidative stress and in Ccl2/Cx3cr1 double deficient mice. Exp Eye Res. 2010 Jul;91(1):15-25.
407 Gaseous nitrogen oxide promotes human lung cancer cell line A549 migration, invasion, and metastasis via iNOS-mediated MMP-2 production. Toxicol Sci. 2008 Dec;106(2):364-75. doi: 10.1093/toxsci/kfn195. Epub 2008 Sep 16.
408 Mechanism of simvastatin-induced K562 cell apoptosis. Pharmacology. 2009;84(4):191-5. doi: 10.1159/000235907. Epub 2009 Sep 2.
409 The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor kappaB pathway in Chang Liver cells. Eur J Pharmacol. 2007 Feb 28;557(2-3):221-9.
410 Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model. Toxicol In Vitro. 2009 Oct;23(7):1387-95.
411 D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis. Apoptosis. 2012 Oct;17(10):1079-94.
412 Integrated analysis of rifampicin-induced microRNA and gene expression changes in human hepatocytes. Drug Metab Pharmacokinet. 2014;29(4):333-40.
413 Trans-Resveratrol in Gnetum gnemon protects against oxidative-stress-induced endothelial senescence. J Nat Prod. 2013 Jul 26;76(7):1242-7.
414 Quercetin induces the expression of peroxiredoxins 3 and 5 via the Nrf2/NRF1 transcription pathway. Invest Ophthalmol Vis Sci. 2011 Feb 22;52(2):1055-63. doi: 10.1167/iovs.10-5777.
415 Troglitazone induces cytotoxicity in part by promoting the degradation of peroxisome proliferator-activated receptor co-activator-1 protein. Br J Pharmacol. 2010 Oct;161(4):771-81. doi: 10.1111/j.1476-5381.2010.00900.x.
416 Plasmatic concentration of organochlorine lindane acts as metabolic disruptors in HepG2 liver cell line by inducing mitochondrial disorder. Toxicol Appl Pharmacol. 2013 Oct 15;272(2):325-34.
417 The effect of ethidium bromide and chloramphenicol on mitochondrial biogenesis in primary human fibroblasts. Toxicol Appl Pharmacol. 2012 May 15;261(1):42-9. doi: 10.1016/j.taap.2012.03.009.
418 Deficiency of the human mitochondrial transcription factor h-mtTFA in infantile mitochondrial myopathy is associated with mtDNA depletion. Hum Mol Genet. 1994 Oct;3(10):1763-9. doi: 10.1093/hmg/3.10.1763.
419 PPARgama activation rescues mitochondrial function from inhibition of complex I and loss of PINK1. Exp Neurol. 2014 Mar;253:16-27.
420 Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
421 From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
422 High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities. Arch Toxicol. 2017 Mar;91(3):1367-1383. doi: 10.1007/s00204-016-1781-0. Epub 2016 Jun 29.
423 Gene expression profiling of breast cancer cells in response to gemcitabine: NF-kappaB pathway activation as a potential mechanism of resistance. Breast Cancer Res Treat. 2007 Apr;102(2):157-72.
424 Association of H3K79 monomethylation (an epigenetic signature) with arsenic-induced skin lesions. Mutat Res. 2018 Jan;807:1-9. doi: 10.1016/j.mrfmmm.2017.11.001. Epub 2017 Nov 14.
425 Effects of Benzophenone-3 and Propylparaben on Estrogen Receptor-Dependent R-Loops and DNA Damage in Breast Epithelial Cells and Mice. Environ Health Perspect. 2020 Jan;128(1):17002. doi: 10.1289/EHP5221. Epub 2020 Jan 15.
426 Quercetin exerts bidirectional regulation effects on the efficacy of tamoxifen in estrogen receptor-positive breast cancer therapy: An in vitro study. Environ Toxicol. 2020 Nov;35(11):1179-1193. doi: 10.1002/tox.22983. Epub 2020 Jun 12.
427 Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. Genome Res. 2012 Nov;22(11):2153-62.
428 Effects of four-week high-fructose diet on gene expression in skeletal muscle of healthy men. Diabetes Metab. 2008 Feb;34(1):82-5. doi: 10.1016/j.diabet.2007.08.004. Epub 2007 Dec 11.
429 Glucosamine-induced endoplasmic reticulum stress affects GLUT4 expression via activating transcription factor 6 in rat and human skeletal muscle cells. Diabetologia. 2010 May;53(5):955-65. doi: 10.1007/s00125-010-1676-1. Epub 2010 Feb 18.
430 AMPK activator acadesine fails to alleviate isoniazid-caused mitochondrial instability in HepG2 cells. J Appl Toxicol. 2017 Oct;37(10):1219-1224. doi: 10.1002/jat.3483. Epub 2017 May 29.
431 Advantageous use of HepaRG cells for the screening and mechanistic study of drug-induced steatosis. Toxicol Appl Pharmacol. 2016 Jul 1;302:1-9. doi: 10.1016/j.taap.2016.04.007. Epub 2016 Apr 16.
432 A cardiac-specific robotized cellular assay identified families of human ligands as inducers of PGC-1 expression and mitochondrial biogenesis. PLoS One. 2012;7(10):e46753. doi: 10.1371/journal.pone.0046753. Epub 2012 Oct 3.
433 Neuronal and cardiac toxicity of pharmacological compounds identified through transcriptomic analysis of human pluripotent stem cell-derived embryoid bodies. Toxicol Appl Pharmacol. 2021 Dec 15;433:115792. doi: 10.1016/j.taap.2021.115792. Epub 2021 Nov 3.
434 Differential expression of microRNAs and their predicted targets in renal cells exposed to amphotericin B and its complex with copper (II) ions. Toxicol Mech Methods. 2017 Sep;27(7):537-543. doi: 10.1080/15376516.2017.1333554. Epub 2017 Jun 8.
435 Identification of genomic biomarkers for anthracycline-induced cardiotoxicity in human iPSC-derived cardiomyocytes: an in vitro repeated exposure toxicity approach for safety assessment. Arch Toxicol. 2016 Nov;90(11):2763-2777.
436 Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018 Nov;121:214-223. doi: 10.1016/j.fct.2018.08.034. Epub 2018 Aug 26.
437 Low-dose Bisphenol A exposure alters the functionality and cellular environment in a human cardiomyocyte model. Environ Pollut. 2023 Oct 15;335:122359. doi: 10.1016/j.envpol.2023.122359. Epub 2023 Aug 9.
438 [Muscular damage during isotretinoin treatment]. Ann Dermatol Venereol. 1998 Feb;125(2):94-7.
439 Elevation of creatine kinase from skeletal muscle associated with inhaled albuterol. Ann Allergy Asthma Immunol. 1996 Dec;77(6):488-90. doi: 10.1016/S1081-1206(10)63356-X.
440 Myopathy and hypersensitivity to phenytoin. Neurology. 1983 Jun;33(6):790-1. doi: 10.1212/wnl.33.6.790.
441 Myositis in association with carbimazole therapy. Lancet. 1989 Apr 29;1(8644):964. doi: 10.1016/s0140-6736(89)92550-6.
442 Premature termination codon readthrough in human cells occurs in novel cytoplasmic foci and requires UPF proteins. J Cell Sci. 2017 Sep 15;130(18):3009-3022. doi: 10.1242/jcs.198176. Epub 2017 Jul 25.
443 Effects of Se-depletion on glutathione peroxidase and selenoprotein W gene expression in the colon. FEBS Lett. 2005 Jan 31;579(3):792-6. doi: 10.1016/j.febslet.2004.12.042.
444 Methotrexate-related response on human peripheral blood mononuclear cells may be modulated by the Ala16Val-SOD2 gene polymorphism. PLoS One. 2014 Oct 20;9(10):e107299. doi: 10.1371/journal.pone.0107299. eCollection 2014.
445 A high-throughput reporter gene assay to prove the ability of natural compounds to modulate glutathione peroxidase, superoxide dismutase and catalase gene promoters in V79 cells. Free Radic Res. 2008 Aug;42(8):746-53.
446 Role of oxidative stress in the apoptosis of hepatocellular carcinoma induced by combination of arsenic trioxide and ascorbic acid. Acta Pharmacol Sin. 2006 Aug;27(8):1078-84.
447 Involvement of oxidative stress in the impairment in biliary secretory function induced by intraperitoneal administration of aluminum to rats. Biol Trace Elem Res. 2007 Jun;116(3):329-48.
448 Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
449 Unique signatures of stress-induced senescent human astrocytes. Exp Neurol. 2020 Dec;334:113466. doi: 10.1016/j.expneurol.2020.113466. Epub 2020 Sep 17.
450 Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. Arch Toxicol. 2016 Jan;90(1):159-80.
451 Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 Feb 26;10(1):3450. doi: 10.1038/s41598-020-59827-1.
452 Atrial-like Engineered Heart Tissue: An In?Vitro Model of the Human Atrium. Stem Cell Reports. 2018 Dec 11;11(6):1378-1390. doi: 10.1016/j.stemcr.2018.10.008. Epub 2018 Nov 8.
453 Cardiac toxicity from ethanol exposure in human-induced pluripotent stem cell-derived cardiomyocytes. Toxicol Sci. 2019 May 1;169(1):280-292.
454 Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
455 Molecular mechanisms of quercitrin-induced apoptosis in non-small cell lung cancer. Arch Med Res. 2014 Aug;45(6):445-54.
456 Muscle glycogen of steroid myopathy patients. J Neurol Sci. 1996 Mar;136(1-2):192-5. doi: 10.1016/0022-510x(95)00331-u.
457 Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
458 The effect of 6-thioguanine on alternative splicing and antisense-mediated exon skipping treatment for duchenne muscular dystrophy. PLoS Curr. 2012 Dec 12;4:ecurrents.md.597d700f92eaa70de261ea0d91821377. doi: 10.1371/currents.md.597d700f92eaa70de261ea0d91821377.
459 Gentamicin administration in Duchenne patients with premature stop codon. Preliminary results. Acta Myol. 2003 May;22(1):15-21.
460 CRISPR/Cas9 editing in human pluripotent stem cell-cardiomyocytes highlights arrhythmias, hypocontractility, and energy depletion as potential therapeutic targets for hypertrophic cardiomyopathy. Eur Heart J. 2018 Nov 14;39(43):3879-3892. doi: 10.1093/eurheartj/ehy249.
461 Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
462 Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4050-61.
463 Arsenic trioxide induces differentiation of cancer stem cells in hepatocellular carcinoma through inhibition of LIF/JAK1/STAT3 and NF-kB signaling pathways synergistically. Clin Transl Med. 2021 Feb;11(2):e335. doi: 10.1002/ctm2.335.
464 Enhanced cytotoxicity of bioreductive antitumor agents with dimethyl fumarate in human glioblastoma cells. Anticancer Drugs. 2005 Feb;16(2):167-74.
465 Growth-suppressive effect of non-steroidal anti-inflammatory drugs on 11 colon-cancer cell lines and fluorescence differential display of genes whose expression is influenced by sulindac. Int J Cancer. 2000 Dec 15;88(6):873-80. doi: 10.1002/1097-0215(20001215)88:6<873::aid-ijc6>3.0.co;2-b.
466 Simvastatin protects dopaminergic neurons against MPP+-induced oxidative stress and regulates the endogenous anti-oxidant system through ERK. Cell Physiol Biochem. 2018;51(4):1957-1968.
467 P450 3A-catalyzed O-dealkylation of lapatinib induces mitochondrial stress and activates Nrf2. Chem Res Toxicol. 2016 May 16;29(5):784-96.
468 Induction of human NAD(P)H:quinone oxidoreductase (NQO1) gene expression by the flavonol quercetin. Toxicol Lett. 2001 Feb 3;119(1):49-57.
469 Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
470 Exposure to Insecticides Modifies Gene Expression and DNA Methylation in Hematopoietic Tissues In Vitro. Int J Mol Sci. 2023 Mar 26;24(7):6259. doi: 10.3390/ijms24076259.
471 Increased matrix proteins, collagen and transforming growth factor are early markers of hepatotoxicity in patients on long-term methotrexate therapy. J Toxicol Clin Toxicol. 1996;34(3):301-5. doi: 10.3109/15563659609013794.
472 Artesunate alleviates liver fibrosis by regulating ferroptosis signaling pathway. Biomed Pharmacother. 2019 Jan;109:2043-2053. doi: 10.1016/j.biopha.2018.11.030. Epub 2018 Nov 26.
473 The effect of DNA methylation inhibitor 5-Aza-2'-deoxycytidine on human endometrial stromal cells. Hum Reprod. 2010 Nov;25(11):2859-69.
474 Coordinate up-regulation of TMEM97 and cholesterol biosynthesis genes in normal ovarian surface epithelial cells treated with progesterone: implications for pathogenesis of ovarian cancer. BMC Cancer. 2007 Dec 11;7:223.
475 Topotecan and methotrexate alter expression of the apoptosis-related genes BCL2, FAS and BCL2L12 in leukemic HL-60 cells. Biol Chem. 2006 Dec;387(12):1629-33. doi: 10.1515/BC.2006.203.
476 Carvedilol prevents epinephrine-induced apoptosis in human coronary artery endothelial cells: modulation of Fas/Fas ligand and caspase-3 pathway. Cardiovasc Res. 2000 Feb;45(3):788-94. doi: 10.1016/s0008-6363(99)00369-7.
477 Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy. Med Oncol. 2011 Dec;28(4):1395-404. doi: 10.1007/s12032-010-9603-3. Epub 2010 Jul 2.
478 Regulatory role of KEAP1 and NRF2 in PPAR expression and chemoresistance in human non-small-cell lung carcinoma cells. Free Radic Biol Med. 2012 Aug 15;53(4):758-68. doi: 10.1016/j.freeradbiomed.2012.05.041. Epub 2012 Jun 7.
479 Non-nutritional sweeteners effects on endothelial vascular function. Toxicol In Vitro. 2020 Feb;62:104694. doi: 10.1016/j.tiv.2019.104694. Epub 2019 Oct 23.
480 Transcriptome-based functional classifiers for direct immunotoxicity. Arch Toxicol. 2014 Mar;88(3):673-89.
481 Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
482 The antipsychotic chlorpromazine suppresses YAP signaling, stemness properties, and drug resistance in breast cancer cells. Chem Biol Interact. 2019 Apr 1;302:28-35. doi: 10.1016/j.cbi.2019.01.033. Epub 2019 Jan 28.
483 Identification of potential biomarkers of hepatitis B-induced acute liver failure using hepatic cells derived from human skin precursors. Toxicol In Vitro. 2015 Sep;29(6):1231-9. doi: 10.1016/j.tiv.2014.10.012. Epub 2014 Oct 24.
484 Dose- and time-dependent transcriptional response of Ishikawa cells exposed to genistein. Toxicol Sci. 2016 May;151(1):71-87.
485 Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(a)pyrene. Toxicol Sci. 2010 Apr;114(2):247-59.
486 Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons. PLoS One. 2009 Sep 23;4(9):e7155.
487 Transcriptome and DNA methylation changes modulated by sulforaphane induce cell cycle arrest, apoptosis, DNA damage, and suppression of proliferation in human liver cancer cells. Food Chem Toxicol. 2020 Feb;136:111047. doi: 10.1016/j.fct.2019.111047. Epub 2019 Dec 12.
488 Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
489 Characterizing fucoxanthin as a selective dopamine D(3)/D(4) receptor agonist: Relevance to Parkinson's disease. Chem Biol Interact. 2019 Sep 1;310:108757. doi: 10.1016/j.cbi.2019.108757. Epub 2019 Jul 16.
490 Unique transcriptome, pathways, and networks in the human endometrial fibroblast response to progesterone in endometriosis. Biol Reprod. 2011 Apr;84(4):801-15.
491 Characterization of the potent, selective Nrf2 activator, 3-(pyridin-3-ylsulfonyl)-5-(trifluoromethyl)-2H-chromen-2-one, in cellular and in vivo models of pulmonary oxidative stress. J Pharmacol Exp Ther. 2017 Oct;363(1):114-125.
492 Response of sodium pump to ouabain challenge in human glioblastoma cells in culture. World J Biol Psychiatry. 2009;10(4 Pt 3):884-92. doi: 10.1080/15622970902995620.
493 Glucocorticoids inhibit cell death in ovarian cancer and up-regulate caspase inhibitor cIAP2. Clin Cancer Res. 2005 Sep 1;11(17):6325-32. doi: 10.1158/1078-0432.CCR-05-0182.
494 Progesterone regulation of implantation-related genes: new insights into the role of oestrogen. Cell Mol Life Sci. 2007 Apr;64(7-8):1009-32.
495 Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells. Exp Eye Res. 2009 Dec;89(6):995-1002. doi: 10.1016/j.exer.2009.08.011. Epub 2009 Sep 1.
496 Endoplasmic reticulum stress contributes to arsenic trioxide-induced intrinsic apoptosis in human umbilical and bone marrow mesenchymal stem cells. Environ Toxicol. 2016 Mar;31(3):314-28.
497 Exome-wide mutation profile in benzo[a]pyrene-derived post-stasis and immortal human mammary epithelial cells. Mutat Res Genet Toxicol Environ Mutagen. 2014 Dec;775-776:48-54. doi: 10.1016/j.mrgentox.2014.10.011. Epub 2014 Nov 4.
498 Chemical stresses fail to mimic the unfolded protein response resulting from luminal load with unfolded polypeptides. J Biol Chem. 2018 Apr 13;293(15):5600-5612.
499 Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
500 A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies. PLoS Med. 2006 Dec;3(12):e486. doi: 10.1371/journal.pmed.0030486.
501 Time series analysis of oxidative stress response patterns in HepG2: a toxicogenomics approach. Toxicology. 2013 Apr 5;306:24-34.
502 Inter-laboratory comparison of human renal proximal tubule (HK-2) transcriptome alterations due to Cyclosporine A exposure and medium exhaustion. Toxicol In Vitro. 2009 Apr;23(3):486-99.
503 Changes in gene expression profiles of multiple myeloma cells induced by arsenic trioxide (ATO): possible mechanisms to explain ATO resistance in vivo. Br J Haematol. 2005 Mar;128(5):636-44.
504 Moving toward integrating gene expression profiling into high-throughput testing: a gene expression biomarker accurately predicts estrogen receptor alpha modulation in a microarray compendium. Toxicol Sci. 2016 May;151(1):88-103.
505 Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell. 2009 Aug 21;138(4):645-659. doi: 10.1016/j.cell.2009.06.034. Epub 2009 Aug 13.
506 Effects of progesterone treatment on expression of genes involved in uterine quiescence. Reprod Sci. 2011 Aug;18(8):781-97.
507 Characterisation of cisplatin-induced transcriptomics responses in primary mouse hepatocytes, HepG2 cells and mouse embryonic stem cells shows conservation of regulating transcription factor networks. Mutagenesis. 2014 Jan;29(1):17-26.
508 Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur J Nutr. 2005 Mar;44(3):143-56. doi: 10.1007/s00394-004-0503-1. Epub 2004 Apr 30.
509 The PPAR gamma agonist troglitazone induces musclin mRNA expression in human myotubes. Horm Metab Res. 2006 Sep;38(9):614-6. doi: 10.1055/s-2006-951310.
510 Retinoic acids and trichostatin A (TSA), a histone deacetylase inhibitor, induce human pyruvate dehydrogenase kinase 4 (PDK4) gene expression. Biochim Biophys Acta. 2006 Mar-Apr;1759(3-4):141-51. doi: 10.1016/j.bbaexp.2006.04.005. Epub 2006 Apr 27.
511 Role of sirtuin 1 in the regulation of hepatic gene expression by thyroid hormone. J Biol Chem. 2013 Jan 11;288(2):807-18. doi: 10.1074/jbc.M112.437970. Epub 2012 Dec 3.
512 Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide. Br J Pharmacol. 2001 Oct;134(4):845-52. doi: 10.1038/sj.bjp.0704327.
513 Comparison of protective effect of ascorbic acid on redox and endocannabinoid systems interactions in in vitro cultured human skin fibroblasts exposed to UV radiation and hydrogen peroxide. Arch Dermatol Res. 2017 May;309(4):285-303. doi: 10.1007/s00403-017-1729-0. Epub 2017 Mar 11.
514 Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells. Chem Res Toxicol. 2014 Mar 17;27(3):408-20.
515 The anthelminthic drug praziquantel is a selective agonist of the sensory transient receptor potential melastatin type 8 channel. Toxicol Appl Pharmacol. 2017 Dec 1;336:55-65. doi: 10.1016/j.taap.2017.10.012. Epub 2017 Oct 18.
516 Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures. Exp Dermatol. 2004 Mar;13(3):129-39. doi: 10.1111/j.0906-6705.2004.0178.x.
517 The vanilloid receptor TRPV1 is activated and sensitized by local anesthetics in rodent sensory neurons. J Clin Invest. 2008 Feb;118(2):763-76. doi: 10.1172/JCI32751.
518 Beta-blockers restore calcium release channel function and improve cardiac muscle performance in human heart failure. Circulation. 2003 May 20;107(19):2459-66. doi: 10.1161/01.CIR.0000068316.53218.49. Epub 2003 May 12.
519 Carvedilol and its new analogs suppress arrhythmogenic store overload-induced Ca2+ release. Nat Med. 2011 Jul 10;17(8):1003-9. doi: 10.1038/nm.2406.
520 Ca2+-activated K+ channels in human leukemic Jurkat T cells. Molecular cloning, biochemical and functional characterization. J Biol Chem. 2000 Dec 22;275(51):39954-63. doi: 10.1074/jbc.M001562200.
521 LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
522 Cyclosporine A--induced oxidative stress in human renal mesangial cells: a role for ERK 1/2 MAPK signaling. Toxicol Sci. 2012 Mar;126(1):101-13.
523 Peroxisome proliferator activated receptor gamma (PPAR-gama) ligand pioglitazone regulated gene networks in term human primary trophoblast cells. Reprod Toxicol. 2018 Oct;81:99-107.
524 Clarifying off-target effects for torcetrapib using network pharmacology and reverse docking approach. BMC Syst Biol. 2012 Dec 10;6:152.
525 Inhibition of CXCL12-mediated chemotaxis of Jurkat cells by direct immunotoxicants. Arch Toxicol. 2016 Jul;90(7):1685-94. doi: 10.1007/s00204-015-1585-7. Epub 2015 Aug 28.
526 Gene expression changes in primary human nasal epithelial cells exposed to formaldehyde in vitro. Toxicol Lett. 2010 Oct 5;198(2):289-95.
527 PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells. J Exp Med. 2006 Oct 2;203(10):2351-62.
528 Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity. Arch Toxicol. 2018 Jan;92(1):469-485.
529 Cannabis-induced cytotoxicity in leukemic cell lines: the role of the cannabinoid receptors and the MAPK pathway. Blood. 2005 Feb 1;105(3):1214-21. doi: 10.1182/blood-2004-03-1182. Epub 2004 Sep 28.
530 Amifostine impairs p53-mediated apoptosis of human myeloid leukemia cells. Mol Cancer Ther. 2003 Sep;2(9):893-900.
531 Characterization of DNA reactive and non-DNA reactive anticancer drugs by gene expression profiling. Mutat Res. 2007 Jun 1;619(1-2):16-29. doi: 10.1016/j.mrfmmm.2006.12.007. Epub 2007 Feb 8.
532 Regulation of DR-5 protein and mitochondrial transmembrane potential by gemcitabine, a possible mechanism of gemcitabine-enhanced TRAIL-induced apoptosis. Oncol Rep. 2007 Sep;18(3):523-9.
533 Amiodarone sensitizes human glioma cells but not astrocytes to TRAIL-induced apoptosis via CHOP-mediated DR5 upregulation. Neuro Oncol. 2011 Mar;13(3):267-79. doi: 10.1093/neuonc/noq195. Epub 2011 Feb 3.
534 Novel functional view of the crocidolite asbestos-treated A549 human lung epithelial transcriptome reveals an intricate network of pathways with opposing functions. BMC Genomics. 2008 Aug 7;9:376.
535 Death receptor 5 regulation during selenium-mediated apoptosis in human prostate cancer cells. Cancer Biol Ther. 2002 May-Jun;1(3):287-90. doi: 10.4161/cbt.83.
536 Death receptor regulation and celecoxib-induced apoptosis in human lung cancer cells. J Natl Cancer Inst. 2004 Dec 1;96(23):1769-80. doi: 10.1093/jnci/djh322.
537 Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery. Mol Cancer. 2006 May 18;5:20. doi: 10.1186/1476-4598-5-20.
538 Gene expression in endometrial cancer cells (Ishikawa) after short time high dose exposure to progesterone. Steroids. 2008 Jan;73(1):116-28.
539 Microtubules are required for NF-kappaB nuclear translocation in neuroblastoma IMR-32 cells: modulation by zinc. J Neurochem. 2006 Oct;99(2):402-15. doi: 10.1111/j.1471-4159.2006.04005.x.
540 Sulindac induces apoptotic cell death in susceptible human breast cancer cells through, at least in part, inhibition of IKKbeta. Apoptosis. 2009 Jul;14(7):913-22. doi: 10.1007/s10495-009-0367-1.
541 Simvastatin potentiates TNF-alpha-induced apoptosis through the down-regulation of NF-kappaB-dependent antiapoptotic gene products: role of IkappaBalpha kinase and TGF-beta-activated kinase-1. J Immunol. 2007 Feb 15;178(4):2507-16. doi: 10.4049/jimmunol.178.4.2507.
542 Pretreatment of acetylsalicylic acid promotes tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by down-regulating BCL-2 gene expression. J Biol Chem. 2005 Dec 9;280(49):41047-56. doi: 10.1074/jbc.M503713200. Epub 2005 Sep 30.
543 Blockade of oncogenic IB kinase activity in diffuse large B-cell lymphoma by bromodomain and extraterminal domain protein inhibitors. Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11365-70. doi: 10.1073/pnas.1411701111. Epub 2014 Jul 21.
544 Sulfasalazine and BAY 11-7082 interfere with the nuclear factor-kappa B and I kappa B kinase pathway to regulate the release of proinflammatory cytokines from human adipose tissue and skeletal muscle in vitro. Endocrinology. 2005 Mar;146(3):1491-7. doi: 10.1210/en.2004-0809. Epub 2004 Nov 24.
545 Retinoid-induced epidermal hyperplasia is mediated by epidermal growth factor receptor activation via specific induction of its ligands heparin-binding EGF and amphiregulin in human skin in vivo. J Invest Dermatol. 2006 Apr;126(4):732-9. doi: 10.1038/sj.jid.5700202.
546 Transcriptomic Analysis of Stem Cells Treated with Moringin or Cannabidiol: Analogies and Differences in Inflammation Pathways. Int J Mol Sci. 2019 Nov 30;20(23):6039. doi: 10.3390/ijms20236039.
547 A peptidyl-glucosamine derivative affects IKKalpha kinase activity in human chondrocytes. Arthritis Res Ther. 2010;12(1):R18. doi: 10.1186/ar2920. Epub 2010 Jan 29.
548 Arsenic trioxide exerts antimyeloma effects by inhibiting activity in the cytoplasmic substrates of histone deacetylase 6. PLoS One. 2012;7(2):e32215. doi: 10.1371/journal.pone.0032215. Epub 2012 Feb 22.
549 Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen. Oncogene. 1999 Dec 2;18(51):7389-94. doi: 10.1038/sj.onc.1203160.
550 Antiepileptic drugs are endocrine disruptors for the human fetal testis ex vivo. Toxicol Sci. 2023 Sep 28;195(2):169-183. doi: 10.1093/toxsci/kfad076.
551 microRNA expression alteration after arsenic trioxide treatment in HepG-2 cells. J Gastroenterol Hepatol. 2011 Jan;26(1):186-93. doi: 10.1111/j.1440-1746.2010.06317.x.
552 In vitro effects of aldehydes present in tobacco smoke on gene expression in human lung alveolar epithelial cells. Toxicol In Vitro. 2013 Apr;27(3):1072-81.
553 mTOR inhibition reverses acquired endocrine therapy resistance of breast cancer cells at the cell proliferation and gene-expression levels. Cancer Sci. 2008 Oct;99(10):1992-2003. doi: 10.1111/j.1349-7006.2008.00955.x.
554 Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
555 Assessment of the cytotoxic, genotoxic, and apoptotic potential of flurbiprofen in HeLa and HepG2 cell lines. J Biochem Mol Toxicol. 2021 Jun;35(6):1-11. doi: 10.1002/jbt.22770. Epub 2021 Mar 11.
556 Apoptotic induction by simvastatin in human lung cancer A549 cells via Akt signaling dependent down-regulation of survivin. Invest New Drugs. 2011 Oct;29(5):945-52. doi: 10.1007/s10637-010-9450-2. Epub 2010 May 13.
557 Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells. Oncogene. 2005 Sep 15;24(41):6213-21. doi: 10.1038/sj.onc.1208774.
558 Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway. Cancer Invest. 2009 Jul;27(6):604-12. doi: 10.1080/07357900802337191.
559 Troglitazone sensitizes tumor cells to TRAIL-induced apoptosis via down-regulation of FLIP and Survivin. Apoptosis. 2006 Sep;11(9):1503-12. doi: 10.1007/s10495-006-8896-3.
560 PGK1 induction by a hydrogen peroxide treatment is suppressed by antioxidants in human colon carcinoma cells. Biosci Biotechnol Biochem. 2008 Jul;72(7):1799-808. doi: 10.1271/bbb.80079. Epub 2008 Jul 7.
561 Peripheral blood expression of nuclear factor-kappab-regulated genes is associated with rheumatoid arthritis disease activity and responds differentially to anti-tumor necrosis factor-alpha versus methotrexate. J Rheumatol. 2007 Sep;34(9):1817-22. Epub 2007 Aug 1.
562 Combination of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and actinomycin D induces apoptosis even in TRAIL-resistant human pancreatic cancer cells. Clin Cancer Res. 2001 Feb;7(2):407-14.
563 Simvastatin induces apoptosis in human colon cancer cells and in tumor xenografts, and attenuates colitis-associated colon cancer in mice. Int J Cancer. 2008 Aug 15;123(4):951-7. doi: 10.1002/ijc.23593.
564 Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells. Biol Pharm Bull. 2013;36(6):944-51. doi: 10.1248/bpb.b12-01004.
565 Rifampicin inhibits CD95-mediated apoptosis of Jurkat T cells via glucocorticoid receptors by modifying the expression of molecules regulating apoptosis. J Clin Immunol. 2002 Jan;22(1):37-47. doi: 10.1023/a:1014256603539.
566 Ethacrynic acid and a derivative enhance apoptosis in arsenic trioxide-treated myeloid leukemia and lymphoma cells: the role of glutathione S-transferase p1-1. Clin Cancer Res. 2012 Dec 15;18(24):6690-701. doi: 10.1158/1078-0432.CCR-12-0770. Epub 2012 Oct 18.
567 Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner. Carcinogenesis. 2009 Aug;30(8):1320-9. doi: 10.1093/carcin/bgp138. Epub 2009 Jun 5.
568 Musashi-1 promotes chemoresistant granule formation by PKR/eIF2 signalling cascade in refractory glioblastoma. Biochim Biophys Acta Mol Basis Dis. 2018 May;1864(5 Pt A):1850-1861. doi: 10.1016/j.bbadis.2018.02.017. Epub 2018 Feb 24.
569 Expression of estrogen-, progesterone-, and androgen-responsive genes in MCF-7 and MDA-MB-231 cells treated with o,p'-DDT, p,p'-DDT, or endosulfan. J Biochem Mol Toxicol. 2021 Jun;35(6):1-8. doi: 10.1002/jbt.22773. Epub 2021 Mar 16.
570 Estrogen-mediated inactivation of FOXO3a by the G protein-coupled estrogen receptor GPER. BMC Cancer. 2015 Oct 15;15:702. doi: 10.1186/s12885-015-1699-6.
571 Differential expression of FOXO1 and FOXO3a confers resistance to oxidative cell death upon endometrial decidualization. Mol Endocrinol. 2006 Oct;20(10):2444-55. doi: 10.1210/me.2006-0118. Epub 2006 May 18.
572 An in vitro study on anti-carcinogenic effect of remdesivir in human ovarian cancer cells via generation of reactive oxygen species. Hum Exp Toxicol. 2022 Jan-Dec;41:9603271221089257. doi: 10.1177/09603271221089257.
573 Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
574 Involvement of mitochondrial dysfunction in nefazodone-induced hepatotoxicity. Food Chem Toxicol. 2016 Aug;94:148-58. doi: 10.1016/j.fct.2016.06.001. Epub 2016 Jun 8.
575 Heat shock protein inhibitors, 17-DMAG and KNK437, enhance arsenic trioxide-induced mitotic apoptosis. Toxicol Appl Pharmacol. 2009 Apr 15;236(2):231-8. doi: 10.1016/j.taap.2009.02.003. Epub 2009 Feb 12.
576 Global effects of inorganic arsenic on gene expression profile in human macrophages. Mol Immunol. 2009 Feb;46(4):649-56.
577 Screening of a chemical library reveals novel PXR-activating pharmacologic compounds. Toxicol Lett. 2015 Jan 5;232(1):193-202. doi: 10.1016/j.toxlet.2014.10.009. Epub 2014 Oct 16.
578 Induction of PXR-mediated metabolism by beta-carotene. Biochim Biophys Acta. 2005 May 30;1740(2):162-9. doi: 10.1016/j.bbadis.2004.11.013. Epub 2004 Dec 8.
579 Lignans, bacteriocides and organochlorine compounds activate the human pregnane X receptor (PXR). Toxicol Appl Pharmacol. 2005 Dec 1;209(2):123-33. doi: 10.1016/j.taap.2005.03.015.
580 Identification and validation of novel human pregnane X receptor activators among prescribed drugs via ligand-based virtual screening. Drug Metab Dispos. 2011 Feb;39(2):337-44. doi: 10.1124/dmd.110.035808. Epub 2010 Nov 10.
581 Identification of HMG-CoA reductase inhibitors as activators for human, mouse and rat constitutive androstane receptor. Drug Metab Dispos. 2005 Jul;33(7):924-9.
582 Acetylated deoxycholic (DCA) and cholic (CA) acids are potent ligands of pregnane X (PXR) receptor. Toxicol Lett. 2017 Jan 4;265:86-96.
583 Checkpoint signaling, base excision repair, and PARP promote survival of colon cancer cells treated with 5-fluorodeoxyuridine but not 5-fluorouracil. PLoS One. 2011;6(12):e28862. doi: 10.1371/journal.pone.0028862. Epub 2011 Dec 15.
584 Direct activation of ATM by resveratrol under oxidizing conditions. PLoS One. 2014 Jun 16;9(6):e97969. doi: 10.1371/journal.pone.0097969. eCollection 2014.
585 Long-term exposure to zidovudine delays cell cycle progression, induces apoptosis, and decreases telomerase activity in human hepatocytes. Toxicol Sci. 2009 Sep;111(1):120-30. doi: 10.1093/toxsci/kfp136. Epub 2009 Jun 18.
586 Lunasin, a novel seed peptide, sensitizes human breast cancer MDA-MB-231 cells to aspirin-arrested cell cycle and induced apoptosis. Chem Biol Interact. 2010 Jul 30;186(2):127-34. doi: 10.1016/j.cbi.2010.04.027. Epub 2010 May 21.
587 Ciprofloxacin mediates cancer stem cell phenotypes in lung cancer cells through caveolin-1-dependent mechanism. Chem Biol Interact. 2016 Apr 25;250:1-11.
588 RNAi-mediated knockdown of aldehyde dehydrogenase class-1A1 and class-3A1 is specific and reveals that each contributes equally to the resistance against 4-hydroperoxycyclophosphamide. Cancer Chemother Pharmacol. 2007 Jan;59(1):127-36. doi: 10.1007/s00280-006-0233-6. Epub 2006 Apr 14.
589 Comparative gene expression analysis of a chronic myelogenous leukemia cell line resistant to cyclophosphamide using oligonucleotide arrays and response to tyrosine kinase inhibitors. Leuk Res. 2007 Nov;31(11):1511-20.
590 A comprehensive analysis of Wnt/beta-catenin signaling pathway-related genes and crosstalk pathways in the treatment of As2O3 in renal cancer. Ren Fail. 2018 Nov;40(1):331-339.
591 Inhibition of aldehyde dehydrogenase-1 and p-glycoprotein-mediated multidrug resistance by curcumin and vitamin D3 increases sensitivity to paclitaxel in breast cancer. Chem Biol Interact. 2020 Jan 5;315:108865. doi: 10.1016/j.cbi.2019.108865. Epub 2019 Oct 16.
592 The interaction of disulfiram and H(2)S metabolism in inhibition of aldehyde dehydrogenase activity and liver cancer cell growth. Toxicol Appl Pharmacol. 2021 Sep 1;426:115642. doi: 10.1016/j.taap.2021.115642. Epub 2021 Jul 6.
593 Cysteine mapping in conformationally distinct kinase nucleotide binding sites: application to the design of selective covalent inhibitors. J Med Chem. 2011 Mar 10;54(5):1347-55. doi: 10.1021/jm101396q. Epub 2011 Feb 15.
594 Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Cancer Res. 2006 Jun 1;66(11):5542-8. doi: 10.1158/0008-5472.CAN-05-4620.
595 Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 2004 May 20;350(21):2129-39. doi: 10.1056/NEJMoa040938. Epub 2004 Apr 29.
596 The dual ErbB1/ErbB2 inhibitor, lapatinib (GW572016), cooperates with tamoxifen to inhibit both cell proliferation- and estrogen-dependent gene expression in antiestrogen-resistant breast cancer. Cancer Res. 2005 Jan 1;65(1):18-25.
597 A fine-needle aspirate-based vulnerability assay identifies polo-like kinase 1 as a mediator of gemcitabine resistance in pancreatic cancer. Mol Cancer Ther. 2010 Feb;9(2):311-8. doi: 10.1158/1535-7163.MCT-09-0693. Epub 2010 Jan 26.
598 Prediction of chemosensitivity using multigene analysis in head and neck squamous cell carcinoma. Oncology. 2007;73(1-2):104-11. doi: 10.1159/000120998. Epub 2008 Mar 13.
599 Inhibition of invasion and induction of apoptosis by selenium in human malignant brain tumour cells in vitro. Int J Oncol. 2007 May;30(5):1263-71.
600 Ligand-dependent activation of the epidermal growth factor receptor by secondary bile acids in polarizing colon cancer cells. Surgery. 2005 Sep;138(3):415-21. doi: 10.1016/j.surg.2005.06.030.
601 Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
602 Selection of drugs to test the specificity of the Tg.AC assay by screening for induction of the gadd153 promoter in vitro. Toxicol Sci. 2003 Aug;74(2):260-70. doi: 10.1093/toxsci/kfg113. Epub 2003 May 2.
603 Methotrexate induces production of IL-1 and IL-6 in the monocytic cell line U937. Arthritis Res Ther. 2014 Jan 20;16(1):R17. doi: 10.1186/ar4444.
604 Simvastatin inhibits NOR-1 expression induced by hyperlipemia by interfering with CREB activation. Cardiovasc Res. 2005 Aug 1;67(2):333-41. doi: 10.1016/j.cardiores.2005.03.016. Epub 2005 Apr 21.
605 The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells. J Biol Chem. 2004 Jun 25;279(26):27008-16. doi: 10.1074/jbc.M403588200. Epub 2004 Apr 16.
606 Species-specific toxicity of diclofenac and troglitazone in primary human and rat hepatocytes. Chem Biol Interact. 2009 Apr 15;179(1):17-24.
607 The psychoactive substance of cannabis 9-tetrahydrocannabinol (THC) negatively regulates CFTR in airway cells. Biochim Biophys Acta Gen Subj. 2018 Sep;1862(9):1988-1994. doi: 10.1016/j.bbagen.2018.06.008. Epub 2018 Jun 19.
608 Carbamazepine, HLA-B*1502 and risk of Stevens-Johnson syndrome and toxic epidermal necrolysis: US FDA recommendations. Pharmacogenomics. 2008 Oct;9(10):1543-6. doi: 10.2217/14622416.9.10.1543.
609 Common risk allele in aromatic antiepileptic-drug induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Han Chinese. Pharmacogenomics. 2010 Mar;11(3):349-56. doi: 10.2217/pgs.09.162.
610 HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol. Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):4134-9. doi: 10.1073/pnas.0409500102. Epub 2005 Mar 2.
611 HLA-B alleles associated with severe cutaneous reactions to antiepileptic drugs in Han Chinese. Epilepsia. 2013 Jul;54(7):1307-14. doi: 10.1111/epi.12217. Epub 2013 May 20.
612 Genetic variations in HLA-B region and hypersensitivity reactions to abacavir. Lancet. 2002 Mar 30;359(9312):1121-2. doi: 10.1016/S0140-6736(02)08158-8.
613 HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. Nat Genet. 2009 Jul;41(7):816-9. doi: 10.1038/ng.379. Epub 2009 May 31.
614 HLA alleles influence the clinical signature of amoxicillin-clavulanate hepatotoxicity. PLoS One. 2013 Jul 9;8(7):e68111. doi: 10.1371/journal.pone.0068111. Print 2013.
615 Relationships and distinctions in iron-regulatory networks responding to interrelated signals. Blood. 2003 May 1;101(9):3690-8. doi: 10.1182/blood-2002-07-2140. Epub 2002 Sep 26.
616 Differential effects of statins on relevant functions of human monocyte-derived dendritic cells. J Leukoc Biol. 2006 Mar;79(3):529-38. doi: 10.1189/jlb.0205064. Epub 2005 Dec 30.
617 Quantitative proteomic analysis of HepG2 cells treated with quercetin suggests IQGAP1 involved in quercetin-induced regulation of cell proliferation and migration. OMICS. 2009 Apr;13(2):93-103. doi: 10.1089/omi.2008.0075.
618 Arsenic trioxide induces apoptosis of human monocytes during macrophagic differentiation through nuclear factor-kappaB-related survival pathway down-regulation. J Pharmacol Exp Ther. 2006 Jan;316(1):304-14. doi: 10.1124/jpet.105.092874. Epub 2005 Sep 20.
619 Phenolic metabolites of benzene inhibited the erythroid differentiation of K562 cells. Toxicol Lett. 2011 Jun 24;203(3):190-9. doi: 10.1016/j.toxlet.2011.03.012. Epub 2011 Mar 23.
620 Fumarate Mediates a Chronic Proliferative Signal in Fumarate Hydratase-Inactivated Cancer Cells by Increasing Transcription and Translation of Ferritin Genes. Mol Cell Biol. 2017 May 16;37(11):e00079-17. doi: 10.1128/MCB.00079-17. Print 2017 Jun 1.
621 Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7653-8.
622 Keratinocyte gene expression profiles discriminate sensitizing and irritating compounds. Toxicol Sci. 2010 Sep;117(1):81-9.
623 Comparison of replicative senescence and stress-induced premature senescence combining differential display and low-density DNA arrays. FEBS Lett. 2005 Jul 4;579(17):3651-9. doi: 10.1016/j.febslet.2005.05.056.
624 Expression pattern of cisplatin-induced metallothionein isoforms in squamous cell carcinoma. Anticancer Res. 2003 Jan-Feb;23(1A):299-303.
625 Identification of novel activators of the metal responsive transcription factor (MTF-1) using a gene expression biomarker in a microarray compendium. Metallomics. 2020 Sep 23;12(9):1400-1415. doi: 10.1039/d0mt00071j.
626 Expression of antioxidant proteins in human intestinal Caco-2 cells treated with dietary flavonoids. Cancer Lett. 1999 Nov 15;146(2):161-7.
627 JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Oncogene. 2008 Aug 28;27(37):5033-44.
628 Oxidative Stress-Protective and Anti-Melanogenic Effects of Loliolide and Ethanol Extract from Fresh Water Green Algae, Prasiola japonica. Int J Mol Sci. 2018 Sep 18;19(9):2825. doi: 10.3390/ijms19092825.
629 The effects of a novel synthetic retinoid, seletinoid G, on the expression of extracellular matrix proteins in aged human skin in vivo. Clin Chim Acta. 2005 Dec;362(1-2):161-9. doi: 10.1016/j.cccn.2005.06.016. Epub 2005 Aug 1.
630 Ciprofloxacin enhances the stimulation of matrix metalloproteinase 3 expression by interleukin-1beta in human tendon-derived cells. A potential mechanism of fluoroquinolone-induced tendinopathy. Arthritis Rheum. 2002 Nov;46(11):3034-40. doi: 10.1002/art.10617.
631 Simvastatin reduces MMP1 expression in human smooth muscle cells cultured on polymerized collagen by inhibiting Rac1 activation. Arterioscler Thromb Vasc Biol. 2007 May;27(5):1043-9. doi: 10.1161/ATVBAHA.107.139881. Epub 2007 Feb 15.
632 Quercetin inhibits matrix metalloproteinase-1 expression in human vascular endothelial cells through extracellular signal-regulated kinase. Arch Biochem Biophys. 2001 Jul 1;391(1):72-8. doi: 10.1006/abbi.2001.2402.
633 Rofecoxib regulates the expression of genes related to the matrix metalloproteinase pathway in humans: implication for the adverse effects of cyclooxygenase-2 inhibitors. Clin Pharmacol Ther. 2006 Apr;79(4):303-15. doi: 10.1016/j.clpt.2005.12.306.
634 Interaction between the aryl hydrocarbon receptor and retinoic acid pathways increases matrix metalloproteinase-1 expression in keratinocytes. J Biol Chem. 2004 Jun 11;279(24):25284-93. doi: 10.1074/jbc.M402168200. Epub 2004 Apr 9.
635 Neuroprotective effects of glucomoringin-isothiocyanate against H(2)O(2)-Induced cytotoxicity in neuroblastoma (SH-SY5Y) cells. Neurotoxicology. 2019 Dec;75:89-104. doi: 10.1016/j.neuro.2019.09.008. Epub 2019 Sep 12.
636 Changes in gene expression profiles in response to selenium supplementation among individuals with arsenic-induced pre-malignant skin lesions. Toxicol Lett. 2007 Mar 8;169(2):162-76. doi: 10.1016/j.toxlet.2007.01.006. Epub 2007 Jan 19.
637 Epinephrine upregulates superoxide dismutase in human coronary artery endothelial cells. Free Radic Biol Med. 2001 Jan 15;30(2):148-53.
638 Cissus quadrangularis ethanol extract upregulates superoxide dismutase, glutathione peroxidase and endothelial nitric oxide synthase expression in hydrogen peroxide-injured human ECV304 cells. J Ethnopharmacol. 2012 Sep 28;143(2):664-72.
639 Manganese superoxide dismutase is a promising target for enhancing chemosensitivity of basal-like breast carcinoma. Antioxid Redox Signal. 2014 May 20;20(15):2326-46. doi: 10.1089/ars.2013.5295. Epub 2013 Nov 14.
640 HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans. N Engl J Med. 2011 Mar 24;364(12):1134-43. doi: 10.1056/NEJMoa1013297.
641 Positive and negative associations of HLA class I alleles with allopurinol-induced SCARs in Koreans. Pharmacogenet Genomics. 2011 May;21(5):303-7. doi: 10.1097/FPC.0b013e32834282b8.
642 A study of HLA class I and class II 4-digit allele level in Stevens-Johnson syndrome and toxic epidermal necrolysis. Int J Immunogenet. 2011 Aug;38(4):303-9. doi: 10.1111/j.1744-313X.2011.01011.x. Epub 2011 May 4.
643 Ticlopidine-induced hepatotoxicity is associated with specific human leukocyte antigen genomic subtypes in Japanese patients: a preliminary case-control study. Pharmacogenomics J. 2008 Feb;8(1):29-33. doi: 10.1038/sj.tpj.6500442. Epub 2007 Mar 6.
644 Cannabidiol and Oxygen-Ozone Combination Induce Cytotoxicity in Human Pancreatic Ductal Adenocarcinoma Cell Lines. Cancers (Basel). 2020 Sep 27;12(10):2774. doi: 10.3390/cancers12102774.
645 Down-regulation of HER-2 expression in human breast cancer cell HBC-4 and ZR75-1 by nitrogen-mustard-N-oxide. Kobe J Med Sci. 2007;53(4):135-42.
646 Epidermal growth factor receptor activity determines response of colorectal cancer cells to gefitinib alone and in combination with chemotherapy. Clin Cancer Res. 2005 Oct 15;11(20):7480-9. doi: 10.1158/1078-0432.CCR-05-0328.
647 Inhibition of prostate cancer cell colony formation by the flavonoid quercetin correlates with modulation of specific regulatory genes. Clin Diagn Lab Immunol. 2004 Jan;11(1):63-9. doi: 10.1128/cdli.11.1.63-69.2004.
648 p53-R175H mutant gains new function in regulation of doxorubicin-induced apoptosis. Int J Cancer. 2005 Apr 10;114(3):331-6. doi: 10.1002/ijc.20818.
649 Azidothymidine and cisplatin increase p14ARF expression in OVCAR-3 ovarian cancer cell line. Toxicol Appl Pharmacol. 2006 Oct 1;216(1):89-97. doi: 10.1016/j.taap.2006.04.015. Epub 2006 May 19.
650 Quantitative analysis of gene expression changes in response to genotoxic compounds. Toxicol In Vitro. 2017 Mar;39:15-28. doi: 10.1016/j.tiv.2016.11.004. Epub 2016 Nov 5.
651 Gallic acid potentiates the apoptotic effect of paclitaxel and carboplatin via overexpression of Bax and P53 on the MCF-7 human breast cancer cell line. J Biochem Mol Toxicol. 2021 Feb;35(2):e22638. doi: 10.1002/jbt.22638. Epub 2020 Oct 1.
652 Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage. Nucleic Acids Res. 2009 Jan;37(1):78-95. doi: 10.1093/nar/gkn910. Epub 2008 Nov 16.
653 Nitrogen Mustard Alkylates and Cross-Links p53 in Human Keratinocytes. Chem Res Toxicol. 2022 Apr 18;35(4):636-650. doi: 10.1021/acs.chemrestox.1c00420. Epub 2022 Mar 21.
654 Fulvestrant induces resistance by modulating GPER and CDK6 expression: implication of methyltransferases, deacetylases and the hSWI/SNF chromatin remodelling complex. Br J Cancer. 2013 Nov 12;109(10):2751-62. doi: 10.1038/bjc.2013.583. Epub 2013 Oct 29.
655 Cytochrome P450 1A1/2 induction by antiparasitic drugs: dose-dependent increase in ethoxyresorufin O-deethylase activity and mRNA caused by quinine, primaquine and albendazole in HepG2 cells. Eur J Clin Pharmacol. 2002 Nov;58(8):537-42.
656 Association of CYP1A1 and CYP1B1 inhibition in in vitro assays with drug-induced liver injury. J Toxicol Sci. 2021;46(4):167-176. doi: 10.2131/jts.46.167.
657 Anti-androgenic effect of 6-formylindolo[3,2-b]carbazole (FICZ) in LNCaP cells is mediated by the aryl hydrocarbon-androgen receptors cross-talk. Steroids. 2020 Jan;153:108508. doi: 10.1016/j.steroids.2019.108508. Epub 2019 Oct 3.
658 Pharmacologic profiling of human and rat cytochrome P450 1A1 and 1A2 induction and competition. Arch Toxicol. 2008 Dec;82(12):909-21.
659 Effect of CYP1A1 gene polymorphisms on estrogen metabolism and bone density. J Bone Miner Res. 2005 Feb;20(2):232-9. doi: 10.1359/JBMR.041110. Epub 2004 Nov 16.
660 Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase. Cancer Res. 1999 Feb 1;59(3):607-14.
661 Gene expression changes in human small airway epithelial cells exposed to Delta9-tetrahydrocannabinol. Toxicol Lett. 2005 Aug 14;158(2):95-107.
662 The metallohormone cadmium modulates AhR-associated gene expression in the small intestine of rats similar to ethinyl-estradiol. Arch Toxicol. 2013 Apr;87(4):633-43.
663 Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites. Gastroenterology. 2004 Nov;127(5):1436-45.
664 Indomethacin inhibits cell growth of medullary thyroid carcinoma by reducing cell cycle progression into S phase. Exp Biol Med (Maywood). 2008 Nov;233(11):1433-40. doi: 10.3181/0804-RM-127. Epub 2008 Sep 12.
665 Therapeutically activating RB: reestablishing cell cycle control in endocrine therapy-resistant breast cancer. Endocr Relat Cancer. 2011 Apr 28;18(3):333-45. doi: 10.1530/ERC-10-0262. Print 2011 Jun.
666 Effects and mechanisms of betulinic acid on improving EGFR TKI-resistance of lung cancer cells. Environ Toxicol. 2018 Nov;33(11):1153-1159.
667 BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile. J Biochem Mol Toxicol. 2019 May;33(5):e22286. doi: 10.1002/jbt.22286. Epub 2019 Jan 23.
668 Sulindac induces specific degradation of the HPV oncoprotein E7 and causes growth arrest and apoptosis in cervical carcinoma cells. Cancer Lett. 2007 Jan 8;245(1-2):103-11. doi: 10.1016/j.canlet.2005.12.034. Epub 2006 Feb 20.
669 Melanoma coordinates general and cell-specific mechanisms to promote methotrexate resistance. Exp Cell Res. 2012 Jun 10;318(10):1146-59.
670 HMG-CoA reductase inhibitor simvastatin inhibits cell cycle progression at the G1/S checkpoint in immortalized lymphocytes from Alzheimer's disease patients independently of cholesterol-lowering effects. J Pharmacol Exp Ther. 2008 Jan;324(1):352-9. doi: 10.1124/jpet.107.128959. Epub 2007 Oct 10.
671 Arsenic trioxide downregulates specificity protein (Sp) transcription factors and inhibits bladder cancer cell and tumor growth. Exp Cell Res. 2010 Aug 1;316(13):2174-88. doi: 10.1016/j.yexcr.2010.04.027. Epub 2010 May 8.
672 Quercetin augments TRAIL-induced apoptotic death: involvement of the ERK signal transduction pathway. Biochem Pharmacol. 2008 May 15;75(10):1946-58. doi: 10.1016/j.bcp.2008.02.016. Epub 2008 Mar 10.
673 Peroxisome proliferator-activated receptor-gamma ligands suppress fibronectin gene expression in human lung carcinoma cells: involvement of both CRE and Sp1. Am J Physiol Lung Cell Mol Physiol. 2005 Sep;289(3):L419-28. doi: 10.1152/ajplung.00002.2005. Epub 2005 May 20.
674 Mechanistic basis for overcoming platinum resistance using copper chelating agents. Mol Cancer Ther. 2012 Nov;11(11):2483-94. doi: 10.1158/1535-7163.MCT-12-0580. Epub 2012 Aug 21.
675 Regulation of the high-affinity copper transporter (hCtr1) expression by cisplatin and heavy metals. J Biol Inorg Chem. 2014 Jan;19(1):17-27. doi: 10.1007/s00775-013-1051-z. Epub 2013 Oct 17.
676 Thalidomide and a thalidomide analogue inhibit endothelial cell proliferation in vitro. J Neurooncol. 1999 Jun;43(2):109-14. doi: 10.1023/a:1006202700039.
677 The activity of a novel mithramycin analog is related to its binding to DNA, cellular accumulation, and inhibition of Sp1-driven gene transcription. Chem Biol Interact. 2014 Aug 5;219:123-32. doi: 10.1016/j.cbi.2014.05.019. Epub 2014 Jun 4.
678 Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction. J Toxicol Sci. 2020;45(11):673-680. doi: 10.2131/jts.45.673.
679 Activation of inflammasomes by tyrosine kinase inhibitors of vascular endothelial growth factor receptor: Implications for VEGFR TKIs-induced immune related adverse events. Toxicol In Vitro. 2021 Mar;71:105063. doi: 10.1016/j.tiv.2020.105063. Epub 2020 Dec 1.
680 Dihydroartemisinin induces pyroptosis by promoting the AIM2/caspase-3/DFNA5 axis in breast cancer cells. Chem Biol Interact. 2021 May 1;340:109434. doi: 10.1016/j.cbi.2021.109434. Epub 2021 Mar 6.
681 Identification of biomarkers for the initiation of apoptosis in human preneoplastic colonocytes by proteome analysis. Int J Cancer. 2004 Mar 20;109(2):220-9. doi: 10.1002/ijc.11692.
682 NOTCH signaling is activated in and contributes to resistance in enzalutamide-resistant prostate cancer cells. J Biol Chem. 2019 May 24;294(21):8543-8554. doi: 10.1074/jbc.RA118.006983. Epub 2019 Apr 2.
683 Evidence of securin-mediated resistance to gefitinib-induced apoptosis in human cancer cells. Chem Biol Interact. 2013 Apr 25;203(2):412-22. doi: 10.1016/j.cbi.2013.03.011. Epub 2013 Mar 22.
684 Cigarette smoke and asbestos activate poly-ADP-ribose polymerase in alveolar epithelial cells. J Investig Med. 2001 Jan;49(1):68-76. doi: 10.2310/6650.2001.34092.
685 The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation. J Biochem Mol Toxicol. 1999;13(6):338-47. doi: 10.1002/(sici)1099-0461(1999)13:6<338::aid-jbt8>3.0.co;2-7.
686 Ciprofloxacin mediated cell growth inhibition, S/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line. Clin Cancer Res. 2000 Mar;6(3):891-900.
687 Investigation of molecular mechanisms underlying the antiproliferative effects of colchicine against PC3 prostate cancer cells. Toxicol In Vitro. 2021 Jun;73:105138. doi: 10.1016/j.tiv.2021.105138. Epub 2021 Mar 6.
688 Sulindac enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human lung cancer. Mol Cancer Ther. 2005 Feb;4(2):291-304.
689 Methotrexate induces poly(ADP-ribose) polymerase-dependent, caspase 3-independent apoptosis in subsets of proliferating CD4+ T cells. Clin Exp Immunol. 2007 May;148(2):288-95. doi: 10.1111/j.1365-2249.2007.03335.x. Epub 2007 Feb 7.
690 Monomeric and oligomeric flavanols maintain the endogenous glucocorticoid response in human macrophages in pro-oxidant conditions in vitro. Chem Biol Interact. 2018 Aug 1;291:237-244.
691 Nicotine up-regulates IL-8 expression in human gingival epithelial cells following stimulation with IL-1 or P. gingivalis lipopolysaccharide via nicotinic acetylcholine receptor signalling. Arch Oral Biol. 2012 May;57(5):483-90. doi: 10.1016/j.archoralbio.2011.10.007. Epub 2011 Nov 25.
692 Ca(2+) Signaling and IL-8 Secretion in Human Testicular Peritubular Cells Involve the Cation Channel TRPV2. Int J Mol Sci. 2018 Sep 19;19(9):2829. doi: 10.3390/ijms19092829.
693 Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x. Epub 2009 Apr 8.
694 Nitrogen mustard prevents transport of Fra-1 into the nucleus to promote c-Fos- and FosB-dependent IL-8 induction in injured mouse epidermis. Toxicol Lett. 2020 Feb 1;319:256-263. doi: 10.1016/j.toxlet.2019.10.006. Epub 2019 Oct 19.
695 ERE-independent ERalpha target genes differentially expressed in human breast tumors. Mol Cell Endocrinol. 2005 Dec 21;245(1-2):53-9. doi: 10.1016/j.mce.2005.10.003. Epub 2005 Nov 17.
696 Nitric oxide synthase inhibitors attenuate ozone-induced airway inflammation in guinea pigs. Possible role of interleukin-8. Am J Respir Crit Care Med. 2000 Jan;161(1):249-56. doi: 10.1164/ajrccm.161.1.9804096.
697 Some HIV antiretrovirals increase oxidative stress and alter chemokine, cytokine or adiponectin production in human adipocytes and macrophages. Antivir Ther. 2007;12(4):489-500.
698 Identification of human cell responses to benzene and benzene metabolites. Genomics. 2007 Sep;90(3):324-33.
699 Cell-based and cytokine-directed chemical screen to identify potential anti-multiple myeloma agents. Leuk Res. 2010 Jul;34(7):917-24. doi: 10.1016/j.leukres.2009.12.002. Epub 2010 Feb 8.
700 TBECH, 1,2-dibromo-4-(1,2 dibromoethyl) cyclohexane, alters androgen receptor regulation in response to mutations associated with prostate cancer. Toxicol Appl Pharmacol. 2016 Sep 15;307:91-101. doi: 10.1016/j.taap.2016.07.018. Epub 2016 Jul 27.
701 Targeting chromatin binding regulation of constitutively active AR variants to overcome prostate cancer resistance to endocrine-based therapies. Nucleic Acids Res. 2015 Jul 13;43(12):5880-97. doi: 10.1093/nar/gkv262. Epub 2015 Apr 23.
702 Possible role of adaptive mutation in resistance to antiandrogen in prostate cancer cells. Prostate. 2005 Nov 1;65(3):268-75. doi: 10.1002/pros.20282.
703 Effects of the environmental estrogens bisphenol A, o,p'-DDT, p-tert-octylphenol and coumestrol on apoptosis induction, cell proliferation and the expression of estrogen sensitive molecular parameters in the human breast cancer cell line MCF-7. J Steroid Biochem Mol Biol. 2002 Jan;80(1):61-70. doi: 10.1016/s0960-0760(01)00173-x.
704 Identifying environmental chemicals as agonists of the androgen receptor by using a quantitative high-throughput screening platform. Toxicology. 2017 Jun 15;385:48-58. doi: 10.1016/j.tox.2017.05.001. Epub 2017 May 4.
705 Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor. Sci Rep. 2014 Sep 26;4:6437. doi: 10.1038/srep06437.
706 Prostate specific antigen expression is down-regulated by selenium through disruption of androgen receptor signaling. Cancer Res. 2004 Jan 1;64(1):19-22. doi: 10.1158/0008-5472.can-03-2789.
707 Comparison of the Hershberger assay and androgen receptor binding assay of twelve chemicals. Toxicology. 2004 Feb 15;195(2-3):177-86. doi: 10.1016/j.tox.2003.09.012.
708 Comparative effects of simvastatin and cholestyramine on plasma lipoproteins and CETP in humans. Can J Clin Pharmacol. 1999 Summer;6(2):85-90.
709 Regulation of Hepatic Cholesteryl Ester Transfer Protein Expression and Reverse Cholesterol Transport by Inhibition of DNA Topoisomerase II. J Biol Chem. 2015 Jun 5;290(23):14418-29. doi: 10.1074/jbc.M115.643015. Epub 2015 Apr 25.
710 Arsenic trioxide suppresses liver X receptor and enhances cholesteryl ester transfer protein expression without affecting the liver X receptor in HepG2 cells. Chem Biol Interact. 2016 Oct 25;258:288-96. doi: 10.1016/j.cbi.2016.09.009. Epub 2016 Sep 10.
711 Nevirapine increases high-density lipoprotein cholesterol concentration by stimulation of apolipoprotein A-I production. Arterioscler Thromb Vasc Biol. 2009 Sep;29(9):1336-41. doi: 10.1161/ATVBAHA.109.192088. Epub 2009 Aug 10.
712 Liver X receptor and retinoic X receptor agonists modulate the expression of genes involved in lipid metabolism in human endothelial cells. Int J Mol Med. 2005 Oct;16(4):717-22.
713 Decreased PLTP mass but elevated PLTP activity linked to insulin resistance in HTG: effects of bezafibrate therapy. J Lipid Res. 2003 Aug;44(8):1462-9. doi: 10.1194/jlr.M300008-JLR200. Epub 2003 May 16.
714 Tumor protein translationally controlled 1 is a p53 target gene that promotes cell survival. Cell Cycle. 2013 Jul 15;12(14):2321-8. doi: 10.4161/cc.25404.
715 Detection of gene expression alteration of myeloma cells treated with arsenic trioxide. Zhonghua Xue Ye Xue Za Zhi. 2005 Apr;26(4):209-13.
716 Genomic and proteomic analysis of the effects of cannabinoids on normal human astrocytes. Brain Res. 2008 Jan 29;1191:1-11.
717 Proteomics analysis of the proliferative effect of low-dose ouabain on human endothelial cells. Biol Pharm Bull. 2007 Feb;30(2):247-53. doi: 10.1248/bpb.30.247.
718 Synergistic effect of trichostatin A and 5-aza-2'-deoxycytidine on growth inhibition of pancreatic endocrine tumour cell lines: a proteomic study. Proteomics. 2009 Apr;9(7):1952-66. doi: 10.1002/pmic.200701089.
719 Inhibition of interleukin-1-induced endothelial tissue factor expression by the synthetic cannabinoid WIN 55,212-2. Oncotarget. 2016 Sep 20;7(38):61438-61457. doi: 10.18632/oncotarget.11367.
720 Elucidating mechanisms of toxicity using phenotypic data from primary human cell systems--a chemical biology approach for thrombosis-related side effects. Int J Mol Sci. 2015 Jan 5;16(1):1008-29. doi: 10.3390/ijms16011008.
721 The effects of chemotherapeutic agents on the regulation of thrombin on cell surfaces. Br J Haematol. 2003 Jan;120(2):315-24. doi: 10.1046/j.1365-2141.2003.03971.x.
722 Mechanisms of tissue factor induction by the uremic toxin indole-3 acetic acid through aryl hydrocarbon receptor/nuclear factor-kappa B signaling pathway in human endothelial cells. Arch Toxicol. 2019 Jan;93(1):121-136.
723 Simvastatin attenuates vascular hypercoagulability in cardiac transplant recipients. Transplantation. 2000 May 15;69(9):1830-6. doi: 10.1097/00007890-200005150-00017.
724 Resveratrol and quercetin down-regulate tissue factor expression by human stimulated vascular cells. J Thromb Haemost. 2003 May;1(5):1089-95. doi: 10.1046/j.1538-7836.2003.00217.x.
725 Tissue factors on acute promyelocytic leukemia and endothelial cells are differently regulated by retinoic acid, arsenic trioxide and chemotherapeutic agents. Leukemia. 1999 Jul;13(7):1062-70. doi: 10.1038/sj.leu.2401448.
726 G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently. J Biol Chem. 1993 Apr 15;268(11):8298-308.
727 Synthesis and antitumor evaluation of nitrovinyl biphenyls: anticancer agents based on allocolchicines. ChemMedChem. 2011 May 2;6(5):859-68. doi: 10.1002/cmdc.201100019. Epub 2011 Apr 6.
728 Resveratrol inhibits hydrogen peroxide-induced apoptosis in endothelial cells via the activation of PI3K/Akt by miR-126. J Atheroscler Thromb. 2014;21(2):108-18. doi: 10.5551/jat.19257. Epub 2013 Oct 10.
729 Ouabain impairs cell migration, and invasion and alters gene expression of human osteosarcoma U-2 OS cells. Environ Toxicol. 2017 Nov;32(11):2400-2413. doi: 10.1002/tox.22453. Epub 2017 Aug 10.
730 Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound. Toxicol In Vitro. 2021 Jun;73:105112. doi: 10.1016/j.tiv.2021.105112. Epub 2021 Feb 22.
731 Analysis of estrogen agonism and antagonism of tamoxifen, raloxifene, and ICI182780 in endometrial cancer cells: a putative role for the epidermal growth factor receptor ligand amphiregulin. J Soc Gynecol Investig. 2005 Oct;12(7):e55-67.
732 Amphiregulin is a vitamin D3 target gene in squamous cell and breast carcinoma. Biochem Biophys Res Commun. 2001 Mar 9;281(4):1051-6. doi: 10.1006/bbrc.2001.4466.
733 Cannabinoids synergize with carfilzomib, reducing multiple myeloma cells viability and migration. Oncotarget. 2016 Nov 22;7(47):77543-77557. doi: 10.18632/oncotarget.12721.
734 Hsa-let-7g miRNA regulates the anti-tumor effects of gastric cancer cells under oxidative stress through the expression of DDR genes. J Toxicol Sci. 2015 Jun;40(3):329-38. doi: 10.2131/jts.40.329.
735 Inhibition of cardiomyocyte differentiation of human induced pluripotent stem cells by Ribavirin: Implication for its cardiac developmental toxicity. Toxicology. 2020 Apr 15;435:152422. doi: 10.1016/j.tox.2020.152422. Epub 2020 Feb 26.
736 Synthesis and structure-activity relationships of new antiproliferative and proapoptotic retinoid-related biphenyl-4-yl-acrylic acids. Bioorg Med Chem. 2007 Jul 15;15(14):4863-75. doi: 10.1016/j.bmc.2007.04.057. Epub 2007 May 3.
737 Methotrexate induces apoptosis through p53/p21-dependent pathway and increases E-cadherin expression through downregulation of HDAC/EZH2. Biochem Pharmacol. 2011 Feb 15;81(4):510-7. doi: 10.1016/j.bcp.2010.11.014. Epub 2010 Nov 27.
738 Actinomycin D inhibits the expression of the cystine/glutamate transporter xCT via attenuation of CD133 synthesis in CD133(+) HCC. Chem Biol Interact. 2019 Aug 25;309:108713. doi: 10.1016/j.cbi.2019.06.026. Epub 2019 Jun 19.
739 Simvastatin and purine analogs have a synergic effect on apoptosis of chronic lymphocytic leukemia cells. Ann Hematol. 2010 Nov;89(11):1115-24. doi: 10.1007/s00277-010-0988-z. Epub 2010 May 25.
740 The isoflavonoids genistein and quercetin activate different stress signaling pathways as shown by analysis of site-specific phosphorylation of ATM, p53 and histone H2AX. DNA Repair (Amst). 2004 Mar 4;3(3):235-44. doi: 10.1016/j.dnarep.2003.10.014.
741 The myeloma cell antigen syndecan-1 is lost by apoptotic myeloma cells. Br J Haematol. 1998 Mar;100(4):637-46. doi: 10.1046/j.1365-2141.1998.00623.x.
742 Ribavirin inhibits colorectal cancer growth by downregulating PRMT5 expression and H3R8me2s and H4R3me2s accumulation. Toxicol Appl Pharmacol. 2021 Mar 15;415:115450. doi: 10.1016/j.taap.2021.115450. Epub 2021 Feb 9.
743 CDK4/6 inhibition provides a potent adjunct to Her2-targeted therapies in preclinical breast cancer models. Genes Cancer. 2014 Jul;5(7-8):261-72. doi: 10.18632/genesandcancer.24.
744 Suppression of HER2/HER3-mediated growth of breast cancer cells with combinations of GDC-0941 PI3K inhibitor, trastuzumab, and pertuzumab. Clin Cancer Res. 2009 Jun 15;15(12):4147-56. doi: 10.1158/1078-0432.CCR-08-2814. Epub 2009 Jun 9.
745 Sulindac metabolites induce proteosomal and lysosomal degradation of the epidermal growth factor receptor. Cancer Prev Res (Phila). 2010 Apr;3(4):560-72. doi: 10.1158/1940-6207.CAPR-09-0159. Epub 2010 Mar 23.
746 Specific inhibition of rRNA transcription and dynamic relocation of fibrillarin induced by mercury. Exp Cell Res. 2000 Aug 25;259(1):225-38. doi: 10.1006/excr.2000.4923.
747 Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies. J Biol Chem. 2019 Oct 18;294(42):15218-15234. doi: 10.1074/jbc.RA119.009147. Epub 2019 Jul 8.
748 The thioxotriazole copper(II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cells. J Biol Chem. 2009 Sep 4;284(36):24306-19.
749 The differential effects of neuroleptic drugs and PACAP on the expression of BDNF mRNA and protein in a human glioblastoma cell line. Acta Neurobiol Exp (Wars). 2017;77(3):205-213.
750 Tea polyphenols ameliorates neural redox imbalance and mitochondrial dysfunction via mechanisms linking the key circadian regular Bmal1. Food Chem Toxicol. 2017 Dec;110:189-199. doi: 10.1016/j.fct.2017.10.031. Epub 2017 Oct 20.
751 LncRNA SNHG12 ameliorates bupivacaine-induced neurotoxicity by sponging miR-497-5p to upregulate NLRX1. Hum Exp Toxicol. 2022 Jan-Dec;41:9603271221089001. doi: 10.1177/09603271221089001.
752 Mechanism of arsenic trioxide inhibiting angiogenesis in multiple myeloma. J Huazhong Univ Sci Technolog Med Sci. 2006;26(1):43-6. doi: 10.1007/BF02828035.
753 Activation of the constitutive androstane receptor by monophthalates. Chem Res Toxicol. 2016 Oct 17;29(10):1651-1661.
754 The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate beta-catenin/TCF-4 signaling. Oncogene. 2001 Feb 1;20(5):645-53. doi: 10.1038/sj.onc.1204123.
755 Novel mechanism of cannabidiol-induced apoptosis in breast cancer cell lines. Breast. 2018 Oct;41:34-41. doi: 10.1016/j.breast.2018.06.009. Epub 2018 Jun 22.
756 Cross-talk between non-genomic and genomic signalling pathways--distinct effect profiles of environmental estrogens. Toxicol Appl Pharmacol. 2010 Jun 1;245(2):160-70. doi: 10.1016/j.taap.2010.02.015. Epub 2010 Mar 4.
757 Resveratrol attenuates senescence of adipose-derived mesenchymal stem cells and restores their paracrine effects on promoting insulin secretion of INS-1 cells through Pim-1. Eur Rev Med Pharmacol Sci. 2016;20(6):1203-13.
758 Cell cycle effects of nonsteroidal anti-inflammatory drugs and enhanced growth inhibition in combination with gemcitabine in pancreatic carcinoma cells. J Pharmacol Exp Ther. 2001 Sep;298(3):976-85.
759 Estrogen receptor regulates E2F1 expression to mediate tamoxifen resistance. Mol Cancer Res. 2010 Mar;8(3):343-52. doi: 10.1158/1541-7786.MCR-09-0395. Epub 2010 Mar 9.
760 Down-regulation and decreased activity of cyclin-dependent kinase 2 in H2O2-induced premature senescence. Int J Biochem Cell Biol. 2003 Feb;35(2):246-54. doi: 10.1016/s1357-2725(02)00129-2.
761 Nonsteroidal anti-inflammatory drugs inhibit growth of human neuroendocrine tumor cells via G1 cell-cycle arrest. Int J Cancer. 2003 Dec 10;107(5):844-53. doi: 10.1002/ijc.11446.
762 Simvastatin inhibits cell growth and induces apoptosis and G0/G1 cell cycle arrest in hepatic cancer cells. Int J Mol Med. 2010 Nov;26(5):735-41. doi: 10.3892/ijmm_00000520.
763 Protein phosphatase 2A interacts with and directly dephosphorylates RelA. J Biol Chem. 2001 Dec 21;276(51):47828-33. doi: 10.1074/jbc.M106103200. Epub 2001 Oct 8.
764 Prevention of deoxycholate-induced gastric apoptosis by aspirin: roles of NF-kappaB and PKC signaling. J Surg Res. 2008 Mar;145(1):66-73. doi: 10.1016/j.jss.2007.04.039. Epub 2007 Jul 20.
765 Cannabidiol upregulates melanogenesis through CB1 dependent pathway by activating p38 MAPK and p42/44 MAPK. Chem Biol Interact. 2017 Aug 1;273:107-114. doi: 10.1016/j.cbi.2017.06.005. Epub 2017 Jun 7.
766 Inhibition of activator protein 1 by barbiturates is mediated by differential effects on mitogen-activated protein kinases and the small G proteins ras and rac-1. J Pharmacol Exp Ther. 2004 Dec;311(3):1232-40. doi: 10.1124/jpet.104.071332. Epub 2004 Jul 19.
767 Growth of hormone-dependent MCF-7 breast cancer cells is promoted by constitutive caveolin-1 whose expression is lost in an EGF-R-mediated manner during development of tamoxifen resistance. Breast Cancer Res Treat. 2010 Feb;119(3):575-91. doi: 10.1007/s10549-009-0355-8. Epub 2009 Mar 15.
768 Effect of histamine H1 receptor antagonists on TARC/CCL17 and MDC/CCL22 production from CD14+ cells induced by antigenic stimulation in vitro. Int Arch Allergy Immunol. 2011;155(1):38-51. doi: 10.1159/000318720. Epub 2010 Nov 25.
769 SIRT3 Mediates the Antioxidant Effect of Hydrogen Sulfide in Endothelial Cells. Antioxid Redox Signal. 2016 Feb 20;24(6):329-43. doi: 10.1089/ars.2015.6331. Epub 2015 Nov 10.
770 MAP kinase-signaling controls nuclear translocation of tripeptidyl-peptidase II in response to DNA damage and oxidative stress. Biochem Biophys Res Commun. 2010 Aug 27;399(3):324-30. doi: 10.1016/j.bbrc.2010.06.133. Epub 2010 Jul 17.
771 Proteomic analysis of the cellular response to a potent sensitiser unveils the dynamics of haptenation in living cells. Toxicology. 2020 Dec 1;445:152603. doi: 10.1016/j.tox.2020.152603. Epub 2020 Sep 28.
772 Comparison of quantitation methods in proteomics to define relevant toxicological information on AhR activation of HepG2 cells by BaP. Toxicology. 2021 Jan 30;448:152652. doi: 10.1016/j.tox.2020.152652. Epub 2020 Dec 2.
773 A gene signature-based approach identifies thioridazine as an inhibitor of phosphatidylinositol-3'-kinase (PI3K)/AKT pathway in ovarian cancer cells. Gynecol Oncol. 2011 Jan;120(1):121-7. doi: 10.1016/j.ygyno.2010.10.003. Epub 2010 Oct 29.
774 Activation of the p38 MAPK/Akt/ERK1/2 signal pathways is required for the protein stabilization of CDC6 and cyclin D1 in low-dose arsenite-induced cell proliferation. J Cell Biochem. 2010 Dec 15;111(6):1546-55. doi: 10.1002/jcb.22886.
775 Vitamin D receptor as a master regulator of the c-MYC/MXD1 network. Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18827-32. doi: 10.1073/pnas.1210037109. Epub 2012 Oct 29.
776 Arsenic trioxide-mediated growth inhibition in MC/CAR myeloma cells via cell cycle arrest in association with induction of cyclin-dependent kinase inhibitor, p21, and apoptosis. Cancer Res. 2000 Jun 1;60(11):3065-71.
777 Delta9-tetrahydrocannabinol inhibits cell cycle progression in human breast cancer cells through Cdc2 regulation. Cancer Res. 2006 Jul 1;66(13):6615-21. doi: 10.1158/0008-5472.CAN-05-4566.
778 Rosiglitazone sensitizes MDA-MB-231 breast cancer cells to anti-tumour effects of tumour necrosis factor-alpha, CH11 and CYC202. Endocr Relat Cancer. 2007 Jun;14(2):305-15. doi: 10.1677/ERC-06-0003.
779 Effect of zoledronic acid on oral fibroblasts and epithelial cells: a potential mechanism of bisphosphonate-associated osteonecrosis. Br J Haematol. 2009 Mar;144(5):667-76. doi: 10.1111/j.1365-2141.2008.07504.x. Epub 2008 Nov 20.
780 Estrogen regulation of apoptosis in osteoblasts. Physiol Behav. 2010 Feb 9;99(2):181-5. doi: 10.1016/j.physbeh.2009.04.025. Epub 2009 May 5.
781 Controlled diesel exhaust and allergen coexposure modulates microRNA and gene expression in humans: Effects on inflammatory lung markers. J Allergy Clin Immunol. 2016 Dec;138(6):1690-1700. doi: 10.1016/j.jaci.2016.02.038. Epub 2016 Apr 24.
782 Pro-oxidant induced DNA damage in human lymphoblastoid cells: homeostatic mechanisms of genotoxic tolerance. Toxicol Sci. 2012 Aug;128(2):387-97. doi: 10.1093/toxsci/kfs152. Epub 2012 Apr 26.
783 Differential gene expression of sulindac-treated human breast epithelial cells. Int J Oncol. 2005 Dec;27(6):1727-36.
784 Involvement of the activation of Nrf2/HO-1, p38 MAPK signaling pathways and endoplasmic reticulum stress in furazolidone induced cytotoxicity and S phase arrest in human hepatocyte L02 cells: modulation of curcumin. Toxicol Mech Methods. 2017 Mar;27(3):165-172. doi: 10.1080/15376516.2016.1273424. Epub 2017 Jan 8.
785 Zidovudine induces S-phase arrest and cell cycle gene expression changes in human cells. Mutagenesis. 2005 Mar;20(2):139-46. doi: 10.1093/mutage/gei019. Epub 2005 Mar 22.
786 Glucocorticoids induce G1 arrest of lymphoblastic cells through retinoblastoma protein Rb1 dephosphorylation in childhood acute lymphoblastic leukemia in vivo. Cancer Biol Ther. 2004 May;3(5):470-6. doi: 10.4161/cbt.3.5.838. Epub 2004 May 9.
787 In vitro and in vivo irinotecan-induced changes in expression profiles of cell cycle and apoptosis-associated genes in acute myeloid leukemia cells. Mol Cancer Ther. 2005 Jun;4(6):885-900.
788 "Exposure to the insecticides permethrin and malathion induces leukemia and lymphoma-associated gene aberrations in vitro". Toxicol In Vitro. 2017 Oct;44:17-26. doi: 10.1016/j.tiv.2017.06.013. Epub 2017 Jun 15.
789 Translocation t(12;21) is related to in vitro cellular drug sensitivity to doxorubicin and etoposide in childhood acute lymphoblastic leukemia. Blood. 2004 Oct 15;104(8):2452-7. doi: 10.1182/blood-2003-12-4426. Epub 2004 Jun 24.
790 eIF4E is a critical regulator of human papillomavirus (HPV)-immortalized cervical epithelial (H8) cell growth induced by nicotine. Toxicology. 2019 May 1;419:1-10. doi: 10.1016/j.tox.2019.02.017. Epub 2019 Mar 2.
791 Antidepressant drug sertraline modulates AMPK-MTOR signaling-mediated autophagy via targeting mitochondrial VDAC1 protein. Autophagy. 2021 Oct;17(10):2783-2799. doi: 10.1080/15548627.2020.1841953. Epub 2020 Nov 9.
792 EGFR tyrosine kinase inhibitors activate autophagy as a cytoprotective response in human lung cancer cells. PLoS One. 2011;6(6):e18691. doi: 10.1371/journal.pone.0018691. Epub 2011 Jun 2.
793 Repression of Kisspeptin1 weakens hydrogen peroxide-caused injury in HTR8 cells via adjusting PI3K/AKT/mTOR pathway. J Biochem Mol Toxicol. 2020 May;34(5):e22461. doi: 10.1002/jbt.22461. Epub 2020 Feb 11.
794 Establishment of a 13 genes-based molecular prediction score model to discriminate the neurotoxic potential of food relevant-chemicals. Toxicol Lett. 2022 Feb 1;355:1-18. doi: 10.1016/j.toxlet.2021.10.013. Epub 2021 Nov 5.
795 Quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting VEGFR- 2 regulated AKT/mTOR/P70S6K signaling pathways. PLoS One. 2012;7(10):e47516. doi: 10.1371/journal.pone.0047516. Epub 2012 Oct 18.
796 Hydroquinone-induced endoplasmic reticulum stress affects TK6 cell autophagy and apoptosis via ATF6-mTOR. Environ Toxicol. 2023 Aug;38(8):1874-1890. doi: 10.1002/tox.23814. Epub 2023 May 6.
797 Carbamylation and oxidation of proteins lead to apoptotic death of lymphocytes. Chem Biol Interact. 2017 May 25;270:24-32. doi: 10.1016/j.cbi.2017.04.007. Epub 2017 Apr 8.
798 Actinomycin D and staurosporine, potent apoptosis inducers in vitro, are potentially effective chemotherapeutic agents against glioblastoma multiforme. Cancer Chemother Pharmacol. 2000;45(2):149-56. doi: 10.1007/s002800050023.
799 Quercetin-induced apoptosis of HL-60 cells by reducing PI3K/Akt. Mol Biol Rep. 2012 Jul;39(7):7785-93. doi: 10.1007/s11033-012-1621-0. Epub 2012 May 4.
800 Clonidine Induces Apoptosis of Human Corneal Epithelial Cells through Death Receptors-Mediated, Mitochondria-Dependent Signaling Pathway. Toxicol Sci. 2017 Mar 1;156(1):252-260. doi: 10.1093/toxsci/kfw249.
801 Lovastatin induces apoptosis of anaplastic thyroid cancer cells via inhibition of protein geranylgeranylation and de novo protein synthesis. Endocrinology. 2003 Sep;144(9):3852-9. doi: 10.1210/en.2003-0098.
802 Maternal environmental exposure to bisphenols and epigenome-wide DNA methylation in infant cord blood. Environ Epigenet. 2020 Dec 23;6(1):dvaa021. doi: 10.1093/eep/dvaa021. eCollection 2020.
803 Methotrexate increases expression of cell cycle checkpoint genes via JNK activation. Arthritis Rheum. 2012 Jun;64(6):1780-9. doi: 10.1002/art.34342. Epub 2011 Dec 19.
804 Simvastatin inhibits growth via apoptosis and the induction of cell cycle arrest in human melanoma cells. Melanoma Res. 2008 Apr;18(2):85-94. doi: 10.1097/CMR.0b013e3282f60097.
805 Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: regulation of cyclin-dependent kinases CDK2 and CDK1. Biochem Pharmacol. 2001 May 15;61(10):1205-15. doi: 10.1016/s0006-2952(01)00583-4.
806 Fluoxetine mediates G0/G1 arrest by inducing functional inhibition of cyclin dependent kinase subunit (CKS)1. Biochem Pharmacol. 2008 May 15;75(10):1924-34. doi: 10.1016/j.bcp.2008.02.013. Epub 2008 Feb 17.
807 Induction mechanism of apoptosis by troglitazone through peroxisome proliferator-activated receptor-gamma in gastric carcinoma cells. Anticancer Res. 2003 Jan-Feb;23(1A):267-73.
808 Down-regulation of CD44 contributes to the differentiation of HL-60 cells induced by ATRA or HMBA. Cell Mol Immunol. 2007 Feb;4(1):59-63.
809 Sevoflurane-mediated activation of p38-mitogen-activated stresskinase is independent of apoptosis in Jurkat T-cells. Anesth Analg. 2008 Apr;106(4):1150-60, table of contents. doi: 10.1213/ane.0b013e3181683d37.
810 NF-B potentiates caspase independent hydrogen peroxide induced cell death. PLoS One. 2011 Feb 15;6(2):e16815. doi: 10.1371/journal.pone.0016815.
811 Quercetin induces FasL-related apoptosis, in part, through promotion of histone H3 acetylation in human leukemia HL-60 cells. Oncol Rep. 2011 Feb;25(2):583-91. doi: 10.3892/or.2010.1097. Epub 2010 Dec 10.
812 Influence of antitumor drugs on the expression of Fas system in SW480 colon cancer cells. Eur J Gastroenterol Hepatol. 2006 Oct;18(10):1071-7. doi: 10.1097/01.meg.0000231750.68513.6c.
813 Acrolein enhances epigenetic modifications, FasL expression and hepatocyte toxicity induced by anti-HIV drug Zidovudine. Toxicol In Vitro. 2016 Sep;35:66-76. doi: 10.1016/j.tiv.2016.05.013. Epub 2016 May 26.
814 Chemokine stromal cell-derived factor-1 induction by C/EBPbeta activation is associated with all-trans-retinoic acid-induced leukemic cell differentiation. J Leukoc Biol. 2007 Nov;82(5):1332-9. doi: 10.1189/jlb.1106697. Epub 2007 Jul 26.
815 How benzene and its metabolites affect human marrow derived mesenchymal stem cells. Toxicol Lett. 2012 Oct 17;214(2):145-53. doi: 10.1016/j.toxlet.2012.08.015. Epub 2012 Aug 30.
816 Sevoflurane but not propofol enhances ovarian cancer cell biology through regulating cellular metabolic and signaling mechanisms. Cell Biol Toxicol. 2023 Aug;39(4):1395-1411. doi: 10.1007/s10565-022-09766-6. Epub 2022 Oct 8.
817 Lysosome Fe(2+) release is responsible for etoposide- and cisplatin-induced stemness of small cell lung cancer cells. Environ Toxicol. 2021 Aug;36(8):1654-1663. doi: 10.1002/tox.23161. Epub 2021 May 10.
818 Multi-level gene expression profiles affected by thymidylate synthase and 5-fluorouracil in colon cancer. BMC Genomics. 2006 Apr 3;7:68. doi: 10.1186/1471-2164-7-68.
819 Anti-oncogenic and pro-differentiation effects of clorgyline, a monoamine oxidase A inhibitor, on high grade prostate cancer cells. BMC Med Genomics. 2009 Aug 20;2:55. doi: 10.1186/1755-8794-2-55.
820 Organochloride pesticides induced hepatic ABCG5/G8 expression and lipogenesis in Chinese patients with gallstone disease. Oncotarget. 2016 Jun 7;7(23):33689-702. doi: 10.18632/oncotarget.9399.
821 Low-expressional IGF1 mediated methimazole-induced liver developmental toxicity in fetal mice. Toxicology. 2018 Sep 1;408:70-79. doi: 10.1016/j.tox.2018.07.004. Epub 2018 Jul 7.
822 Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity. Cell Biol Toxicol. 2021 Apr;37(2):151-175. doi: 10.1007/s10565-020-09537-1. Epub 2020 Jun 14.
823 Effect of atorvastatin, simvastatin, and lovastatin on the metabolism of cholesterol and triacylglycerides in HepG2 cells. Biochem Pharmacol. 2001 Dec 1;62(11):1545-55. doi: 10.1016/s0006-2952(01)00790-0.
824 Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):245-55.
825 Synergistic interaction of lovastatin and paclitaxel in human cancer cells. Mol Cancer Ther. 2001 Dec;1(2):141-9.
826 C/EBPalpha inactivation in FAK-overexpressed HL-60 cells impairs cell differentiation. Cell Signal. 2006 Jul;18(7):955-63. doi: 10.1016/j.cellsig.2005.08.014. Epub 2005 Oct 14.
827 Arsenic trioxide promotes senescence and regulates the balance of adipogenic and osteogenic differentiation in human mesenchymal stem cells. Acta Biochim Biophys Sin (Shanghai). 2011 Mar;43(3):204-9. doi: 10.1093/abbs/gmq130. Epub 2011 Jan 21.
828 Effects of nevirapine and efavirenz on human adipocyte differentiation, gene expression, and release of adipokines and cytokines. Antiviral Res. 2011 Aug;91(2):112-9. doi: 10.1016/j.antiviral.2011.04.018. Epub 2011 May 17.
829 High-throughput cell-based screening of 4910 known drugs and drug-like small molecules identifies disulfiram as an inhibitor of prostate cancer cell growth. Clin Cancer Res. 2009 Oct 1;15(19):6070-8.
830 Gingival Stromal Cells as an In Vitro Model: Cannabidiol Modulates Genes Linked With Amyotrophic Lateral Sclerosis. J Cell Biochem. 2017 Apr;118(4):819-828. doi: 10.1002/jcb.25757. Epub 2016 Nov 28.
831 Aspirin and alterations in DNA repair proteins in the SW480 colorectal cancer cell line. Oncol Rep. 2010 Jul;24(1):37-46. doi: 10.3892/or_00000826.
832 A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs. Biochem J. 2004 Dec 1;384(Pt 2):391-400. doi: 10.1042/BJ20041498.
833 Real-time monitoring of cisplatin-induced cell death. PLoS One. 2011;6(5):e19714. doi: 10.1371/journal.pone.0019714. Epub 2011 May 16.
834 Phosphorylation and stabilization of topoisomerase II protein by p38 mitogen-activated protein kinase sensitize breast cancer cells to its poisons. J Biol Chem. 2011 Oct 14;286(41):35883-35890. doi: 10.1074/jbc.M111.229260. Epub 2011 Aug 30.
835 Curcumin suppresses growth of mesothelioma cells in vitro and in vivo, in part, by stimulating apoptosis. Mol Cell Biochem. 2011 Nov;357(1-2):83-94. doi: 10.1007/s11010-011-0878-2. Epub 2011 May 19.
836 Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun. 2008 Dec 19;377(3):797-802.
837 Delta9-tetrahydrocannabinol inhibits cytotrophoblast cell proliferation and modulates gene transcription. Mol Hum Reprod. 2006 May;12(5):321-33. doi: 10.1093/molehr/gal036. Epub 2006 Apr 5.
838 Carotenoid transport is decreased and expression of the lipid transporters SR-BI, NPC1L1, and ABCA1 is downregulated in Caco-2 cells treated with ezetimibe. J Nutr. 2005 Oct;135(10):2305-12. doi: 10.1093/jn/135.10.2305.
839 On the mechanism for PPAR agonists to enhance ABCA1 gene expression. Atherosclerosis. 2009 Aug;205(2):413-9. doi: 10.1016/j.atherosclerosis.2009.01.008. Epub 2009 Jan 19.
840 Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures. Arch Toxicol. 2018 Jun;92(6):1939-1952.
841 Epigenetic changes in individuals with arsenicosis. Chem Res Toxicol. 2011 Feb 18;24(2):165-7. doi: 10.1021/tx1004419. Epub 2011 Feb 4.
842 Cannabidiol Effectively Promoted Cell Death in Bladder Cancer and the Improved Intravesical Adhesion Drugs Delivery Strategy Could Be Better Used for Treatment. Pharmaceutics. 2021 Sep 7;13(9):1415. doi: 10.3390/pharmaceutics13091415.
843 A model to identify novel targets involved in oxidative stress-induced apoptosis in human lung epithelial cells by RNA interference. Toxicol In Vitro. 2010 Feb;24(1):310-8. doi: 10.1016/j.tiv.2009.08.008. Epub 2009 Aug 23.
844 Nitric oxide inhibits execution of apoptosis at two distinct ATP-dependent steps upstream and downstream of mitochondrial cytochrome c release. Biochem Biophys Res Commun. 1999 Apr 29;258(1):215-21. doi: 10.1006/bbrc.1999.0491.
845 Palmitate increases the susceptibility of cells to drug-induced toxicity: an in vitro method to identify drugs with potential contraindications in patients with metabolic disease. Toxicol Sci. 2012 Oct;129(2):346-62. doi: 10.1093/toxsci/kfs208. Epub 2012 Jun 14.
846 Simvastatin induces apoptosis and alters cytoskeleton in endometrial stromal cells. J Clin Endocrinol Metab. 2010 Jul;95(7):3453-9. doi: 10.1210/jc.2010-0072. Epub 2010 Apr 28.
847 Insulin-like growth factor I prevents mannitol-induced degradation of focal adhesion kinase and Akt. J Biol Chem. 2002 Jul 26;277(30):27393-400. doi: 10.1074/jbc.M201963200. Epub 2002 May 14.
848 Effects of gonadotrophin-releasing hormone agonists on apoptosis of granulosa cells. Ann N Y Acad Sci. 2005 May;1042:531-7. doi: 10.1196/annals.1338.065.
849 Inhibiting AKT signaling pathway with cilostazol and meloxicam synergism for suppressing K562 cells in vitro. J Biochem Mol Toxicol. 2022 Nov;36(11):e23185. doi: 10.1002/jbt.23185. Epub 2022 Aug 3.
850 Colchicine-induced apoptosis in human normal liver L-02 cells by mitochondrial mediated pathways. Toxicol In Vitro. 2012 Aug;26(5):649-55. doi: 10.1016/j.tiv.2012.01.024. Epub 2012 Feb 8.
851 Combination of Poly I:C and arsenic trioxide triggers apoptosis synergistically via activation of TLR3 and mitochondrial pathways in hepatocellular carcinoma cells. Cell Biol Int. 2011 Aug;35(8):803-10. doi: 10.1042/CBI20100739.
852 Role of mitochondria in aspirin-induced apoptosis in human gastric epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2005 Oct;289(4):G731-8. doi: 10.1152/ajpgi.00150.2005. Epub 2005 Jun 23.
853 p38 MAPK/PP2Ac/TTP pathway on the connection of TNF- and caspases activation on hydroquinone-induced apoptosis. Carcinogenesis. 2013 Apr;34(4):818-27. doi: 10.1093/carcin/bgs409. Epub 2013 Jan 3.
854 Proteomic identification of differentially expressed proteins associated with the multiple drug resistance in methotrexate-resistant human breast cancer cells. Int J Oncol. 2014 Jul;45(1):448-58.
855 Protein profile in neuroblastoma cells incubated with S- and R-enantiomers of ibuprofen by iTRAQ-coupled 2-D LC-MS/MS analysis: possible action of induced proteins on Alzheimer's disease. Proteomics. 2008 Apr;8(8):1595-607. doi: 10.1002/pmic.200700556.
856 Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21.
857 Cannabidiol Reduces Leukemic Cell Size - But Is It Important?. Front Pharmacol. 2017 Mar 24;8:144. doi: 10.3389/fphar.2017.00144. eCollection 2017.
858 Crizotinib-resistant mutants of EML4-ALK identified through an accelerated mutagenesis screen. Chem Biol Drug Des. 2011 Dec;78(6):999-1005. doi: 10.1111/j.1747-0285.2011.01239.x. Epub 2011 Oct 31.
859 D-glucosamine down-regulates HIF-1alpha through inhibition of protein translation in DU145 prostate cancer cells. Biochem Biophys Res Commun. 2009 Apr 24;382(1):96-101. doi: 10.1016/j.bbrc.2009.02.129. Epub 2009 Feb 28.
860 Proteomics-based identification of differentially abundant proteins from human keratinocytes exposed to arsenic trioxide. J Proteomics Bioinform. 2014 Jul;7(7):166-178.
861 Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling. Aging (Albany NY). 2012 Dec;4(12):952-65. doi: 10.18632/aging.100521.
862 Androgen receptor-mTOR crosstalk is regulated by testosterone availability: implication for prostate cancer cell survival. Anticancer Res. 2010 Oct;30(10):3895-901.
863 Imatinib disturbs lysosomal function and morphology and impairs the activity of mTORC1 in human hepatocyte cell lines. Food Chem Toxicol. 2022 Apr;162:112869. doi: 10.1016/j.fct.2022.112869. Epub 2022 Feb 16.
864 Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine in bladder cancer cells. Oncogene. 2016 Aug 25;35(34):4518-28. doi: 10.1038/onc.2015.511. Epub 2016 Feb 8.
865 Gene expression in benzene-exposed workers by microarray analysis of peripheral mononuclear blood cells: induction and silencing of CYP4F3A and regulation of DNA-dependent protein kinase catalytic subunit in DNA double strand break repair. Chem Biol Interact. 2010 Mar 19;184(1-2):207-11.
866 Ouabain induces apoptotic cell death in human prostate DU 145 cancer cells through DNA damage and TRAIL pathways. Environ Toxicol. 2019 Dec;34(12):1329-1339. doi: 10.1002/tox.22834. Epub 2019 Aug 21.
867 Role of DNA Repair Pathways in Response to Zidovudine-induced DNA Damage in Immortalized Human Liver THLE2 Cells. Int J Biomed Sci. 2013 Mar;9(1):18-25.
868 Comparison of Drug Metabolism and Its Related Hepatotoxic Effects in HepaRG, Cryopreserved Human Hepatocytes, and HepG2 Cell Cultures. Biol Pharm Bull. 2018 May 1;41(5):722-732. doi: 10.1248/bpb.b17-00913. Epub 2018 Feb 14.
869 Blood cell oxidative stress precedes hemolysis in whole blood-liver slice co-cultures of rat, dog, and human tissues. Toxicol Appl Pharmacol. 2010 May 1;244(3):354-65. doi: 10.1016/j.taap.2010.01.017. Epub 2010 Feb 6.
870 Proton pump inhibitors block iron absorption through direct regulation of hepcidin via the aryl hydrocarbon receptor-mediated pathway. Toxicol Lett. 2020 Jan;318:86-91. doi: 10.1016/j.toxlet.2019.10.016. Epub 2019 Oct 24.
871 A HAMP promoter bioassay system for identifying chemical compounds that modulate hepcidin expression. Exp Hematol. 2015 May;43(5):404-413.e5. doi: 10.1016/j.exphem.2015.01.005. Epub 2015 Jan 26.
872 Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression. J Biol Chem. 2006 Aug 11;281(32):22974-82. doi: 10.1074/jbc.M602098200. Epub 2006 May 31.
873 Regulation of ERRalpha gene expression by estrogen receptor agonists and antagonists in SKBR3 breast cancer cells: differential molecular mechanisms mediated by g protein-coupled receptor GPR30/GPER-1. Mol Endocrinol. 2010 May;24(5):969-80. doi: 10.1210/me.2009-0148. Epub 2010 Mar 8.
874 K-RAS transformation in prostate epithelial cell overcomes H2O2-induced apoptosis via upregulation of gamma-glutamyltransferase-2. Toxicol In Vitro. 2012 Apr;26(3):429-34. doi: 10.1016/j.tiv.2012.01.013. Epub 2012 Jan 17.
875 Under ambient UVA exposure, pefloxacin exhibits both immunomodulatory and genotoxic effects via multiple mechanisms. J Photochem Photobiol B. 2018 Jan;178:593-605. doi: 10.1016/j.jphotobiol.2017.12.014. Epub 2017 Dec 15.
876 In vitro antioxidant and antigenotoxic potentials of 3,5-O-di-galloylquinic acid extracted from Myrtus communis leaves and modulation of cell gene expression by H2O2. J Appl Toxicol. 2012 May;32(5):333-41.
877 HMG-CoA reductase inhibitors, statins, induce phosphorylation of Mdm2 and attenuate the p53 response to DNA damage. FASEB J. 2005 Mar;19(3):476-8. doi: 10.1096/fj.04-2745fje. Epub 2004 Dec 29.
878 450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy. Environ Health Perspect. 2012 Oct;120(10):1425-31. doi: 10.1289/ehp.1205412. Epub 2012 Jul 31.
879 Involvement of cytoskeleton in AhR-dependent CYP1A1 expression. Curr Drug Metab. 2006 Apr;7(3):301-13. doi: 10.2174/138920006776359310.
880 Modulation of the expression of bloom helicase by estrogenic agents. Biol Pharm Bull. 2007 Feb;30(2):266-71. doi: 10.1248/bpb.30.266.
881 CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.
882 Responses of genes involved in cell cycle control to diverse DNA damaging chemicals in human lung adenocarcinoma A549 cells. Cancer Cell Int. 2005 Aug 24;5:28. doi: 10.1186/1475-2867-5-28.
883 DNA Methylome Analysis of Saturated Aliphatic Aldehydes in Pulmonary Toxicity. Sci Rep. 2018 Jul 12;8(1):10497. doi: 10.1038/s41598-018-28813-z.
884 Quercetin in elimination of tumor initiating stem-like and mesenchymal transformation property in head and neck cancer. Head Neck. 2013 Mar;35(3):413-9. doi: 10.1002/hed.22982. Epub 2012 Mar 16.
885 Retinoic acid represses a cassette of candidate pluripotency chromosome 12p genes during induced loss of human embryonal carcinoma tumorigenicity. Biochim Biophys Acta. 2005 Oct 15;1731(1):48-56. doi: 10.1016/j.bbaexp.2005.08.006. Epub 2005 Sep 1.
886 Altered expression of genes identified in rats with prostatic chronic inflammation in a prostate spheroid model treated by estradiol/testosterone. J Toxicol Sci. 2021;46(11):515-523. doi: 10.2131/jts.46.515.
887 Effects of Exposure to Acetaminophen and Ibuprofen on Fetal Germ Cell Development in Both Sexes in Rodent and Human Using Multiple Experimental Systems. Environ Health Perspect. 2018 Apr 16;126(4):047006. doi: 10.1289/EHP2307.
888 Curcumin prevents DNA damage and enhances the repair potential in a chronically arsenic-exposed human population in West Bengal, India. Eur J Cancer Prev. 2011 Mar;20(2):123-31. doi: 10.1097/cej.0b013e328341017a.
889 Dietary flavonoids induce MLL translocations in primary human CD34+ cells. Carcinogenesis. 2007 Aug;28(8):1703-9. doi: 10.1093/carcin/bgm102. Epub 2007 Apr 29.
890 Differential responses to retinoic acid and endocrine disruptor compounds of subpopulations within human embryonic stem cell lines. Differentiation. 2012 Nov;84(4):330-43. doi: 10.1016/j.diff.2012.07.006. Epub 2012 Aug 18.
891 Alcohol triggered bile acid disequilibrium by suppressing BSEP to sustain hepatocellular carcinoma progression. Chem Biol Interact. 2022 Apr 1;356:109847. doi: 10.1016/j.cbi.2022.109847. Epub 2022 Feb 9.
892 Prefrontal dysfunction in schizophrenia involves mixed-lineage leukemia 1-regulated histone methylation at GABAergic gene promoters. J Neurosci. 2007 Oct 17;27(42):11254-62. doi: 10.1523/JNEUROSCI.3272-07.2007.
893 Combining kallistatin gene therapy and meloxicam to treat hepatocellular carcinoma in mice. Cancer Sci. 2009 Nov;100(11):2226-33. doi: 10.1111/j.1349-7006.2009.01306.x. Epub 2009 Aug 4.
894 The role of MITF and Mcl-1 proteins in the antiproliferative and proapoptotic effect of ciprofloxacin in amelanotic melanoma cells: In silico and in vitro study. Toxicol In Vitro. 2020 Aug;66:104884. doi: 10.1016/j.tiv.2020.104884. Epub 2020 May 8.
895 Quercetin downregulates Mcl-1 by acting on mRNA stability and protein degradation. Br J Cancer. 2011 Jul 12;105(2):221-30. doi: 10.1038/bjc.2011.229.
896 Anti-cancer properties of glucosamine-hydrochloride in YD-8 human oral cancer cells: Induction of the caspase-dependent apoptosis and down-regulation of HIF-1. Toxicol In Vitro. 2012 Feb;26(1):42-50. doi: 10.1016/j.tiv.2011.10.005. Epub 2011 Oct 13.
897 Oxidative stress induces parallel autophagy and mitochondria dysfunction in human glioma U251 cells. Toxicol Sci. 2009 Aug;110(2):376-88. doi: 10.1093/toxsci/kfp101. Epub 2009 May 18.
898 Simvastatin induces activation of the serine-threonine protein kinase AKT and increases survival of isolated human pancreatic islets. Transplantation. 2002 Oct 27;74(8):1063-9. doi: 10.1097/00007890-200210270-00001.
899 Characterization of arsenic trioxide resistant clones derived from Jurkat leukemia T cell line: focus on PI3K/Akt signaling pathway. Chem Biol Interact. 2013 Oct 5;205(3):198-211. doi: 10.1016/j.cbi.2013.07.011. Epub 2013 Aug 2.
900 The potential effects of HECTD4 variants on fasting glucose and triglyceride levels in relation to prevalence of type 2 diabetes based on alcohol intake. Arch Toxicol. 2022 Sep;96(9):2487-2499. doi: 10.1007/s00204-022-03325-y. Epub 2022 Jun 17.
901 Rosiglitazone upregulates caveolin-1 expression in THP-1 cells through a PPAR-dependent mechanism. J Lipid Res. 2004 Nov;45(11):2015-24. doi: 10.1194/jlr.M400049-JLR200. Epub 2004 Aug 16.
902 Comparison of the effects of pioglitazone and rosiglitazone on macrophage foam cell formation. Biochem Biophys Res Commun. 2004 Oct 22;323(3):782-8.
903 Cannabidiol Induces Cell Cycle Arrest and Cell Apoptosis in Human Gastric Cancer SGC-7901 Cells. Biomolecules. 2019 Jul 25;9(8):302. doi: 10.3390/biom9080302.
904 Correction of ATM gene function by aminoglycoside-induced read-through of premature termination codons. Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15676-81. doi: 10.1073/pnas.0405155101. Epub 2004 Oct 21.
905 Effects of lithium and valproic acid on gene expression and phenotypic markers in an NT2 neurosphere model of neural development. PLoS One. 2013;8(3):e58822.
906 Resveratrol modifies the expression of apoptotic regulatory proteins and sensitizes non-Hodgkin's lymphoma and multiple myeloma cell lines to paclitaxel-induced apoptosis. Mol Cancer Ther. 2004 Jan;3(1):71-84.
907 The hepatotoxic fluoroquinolone trovafloxacin disturbs TNF- and LPS-induced p65 nuclear translocation in vivo and in vitro. Toxicol Appl Pharmacol. 2020 Mar 15;391:114915. doi: 10.1016/j.taap.2020.114915. Epub 2020 Feb 6.
908 Benzodithiophenes potentiate differentiation of acute promyelocytic leukemia cells by lowering the threshold for ligand-mediated corepressor/coactivator exchange with retinoic acid receptor alpha and enhancing changes in all-trans-retinoic acid-regulated gene expression. Cancer Res. 2005 Sep 1;65(17):7856-65. doi: 10.1158/0008-5472.CAN-05-1056.
909 Antitumor action of the MET tyrosine kinase inhibitor crizotinib (PF-02341066) in gastric cancer positive for MET amplification. Mol Cancer Ther. 2012 Jul;11(7):1557-64. doi: 10.1158/1535-7163.MCT-11-0934. Epub 2012 Jun 22.
910 Inhibition of PI3K pathway using BKM120 intensified the chemo-sensitivity of breast cancer cells to arsenic trioxide (ATO). Int J Biochem Cell Biol. 2019 Nov;116:105615. doi: 10.1016/j.biocel.2019.105615. Epub 2019 Sep 17.
911 Etodolac inhibits EBER expression and induces Bcl-2-regulated apoptosis in Burkitt's lymphoma cells. Eur J Haematol. 2005 Sep;75(3):212-20. doi: 10.1111/j.1600-0609.2005.00498.x.
912 Apoptosis induction by 1alpha,25-dihydroxyvitamin D3 in prostate cancer. Mol Cancer Ther. 2002 Jul;1(9):667-77.
913 Statin-triggered cell death in primary human lung mesenchymal cells involves p53-PUMA and release of Smac and Omi but not cytochrome c. Biochim Biophys Acta. 2010 Apr;1803(4):452-67. doi: 10.1016/j.bbamcr.2009.12.005. Epub 2010 Jan 4.
914 Adipogenic Effects and Gene Expression Profiling of Firemaster? 550 Components in Human Primary Preadipocytes. Environ Health Perspect. 2017 Sep 14;125(9):097013. doi: 10.1289/EHP1318.
915 Comparison of the gene expression profiles of monocytic versus granulocytic lineages of HL-60 leukemia cell differentiation by DNA microarray analysis. Life Sci. 2003 Aug 15;73(13):1705-19. doi: 10.1016/s0024-3205(03)00515-0.
916 Proteomic analysis of anti-cancer effects by paclitaxel treatment in cervical cancer cells. Gynecol Oncol. 2005 Jul;98(1):45-53. doi: 10.1016/j.ygyno.2005.04.010.
917 BTG3 tumor suppressor gene promoter demethylation, histone modification and cell cycle arrest by genistein in renal cancer. Carcinogenesis. 2009 Apr;30(4):662-70. doi: 10.1093/carcin/bgp042. Epub 2009 Feb 12.
918 Folic acid modulates cancer-associated micro RNAs and inflammatory mediators in neoplastic and non-neoplastic colonic cells in a different way. Mol Nutr Food Res. 2017 Dec;61(12). doi: 10.1002/mnfr.201700260. Epub 2017 Nov 9.
919 Additive effects of 5-aza-2'-deoxycytidine and irradiation on clonogenic survival of human medulloblastoma cell lines. Strahlenther Onkol. 2009 May;185(5):331-8. doi: 10.1007/s00066-009-1956-1. Epub 2009 May 15.
920 Progesterone promotes differentiation of human cord blood fetal T cells into T regulatory cells but suppresses their differentiation into Th17 cells. J Immunol. 2011 Aug 15;187(4):1778-87. doi: 10.4049/jimmunol.1003919. Epub 2011 Jul 18.
921 Arsenic trioxide and cisplatin synergism increase cytotoxicity in human ovarian cancer cells: therapeutic potential for ovarian cancer. Cancer Sci. 2009 Dec;100(12):2459-64.
922 Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain. J Biol Chem. 2003 Aug 15;278(33):30748-54. doi: 10.1074/jbc.M304824200. Epub 2003 May 31.
923 27-hydroxycholesterol is an endogenous selective estrogen receptor modulator. Mol Endocrinol. 2008 Jan;22(1):65-77. doi: 10.1210/me.2007-0383. Epub 2007 Sep 13.
924 The genomic response of a human uterine endometrial adenocarcinoma cell line to 17alpha-ethynyl estradiol. Toxicol Sci. 2009 Jan;107(1):40-55.
925 MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia. Cell Biol Toxicol. 2023 Feb;39(1):201-216. doi: 10.1007/s10565-021-09639-4. Epub 2021 Sep 28.
926 Suppression of transforming growth factor beta/smad signaling in keloid-derived fibroblasts by quercetin: implications for the treatment of excessive scars. J Trauma. 2004 Nov;57(5):1032-7. doi: 10.1097/01.ta.0000114087.46566.eb.
927 Glucosamine promotes osteogenic differentiation of dental pulp stem cells through modulating the level of the transforming growth factor-beta type I receptor. J Cell Physiol. 2010 Oct;225(1):140-51.
928 The differential cancer growth associated with anaesthetics in a cancer xenograft model of mice: mechanisms and implications of postoperative cancer recurrence. Cell Biol Toxicol. 2023 Aug;39(4):1561-1575. doi: 10.1007/s10565-022-09747-9. Epub 2022 Aug 12.
929 Classification of heavy-metal toxicity by human DNA microarray analysis. Environ Sci Technol. 2007 May 15;41(10):3769-74.
930 The retinoid anticancer signal: mechanisms of target gene regulation. Br J Cancer. 2005 Aug 8;93(3):310-8. doi: 10.1038/sj.bjc.6602700.
931 Inhibition of fatty acid synthase expression by 1alpha,25-dihydroxyvitamin D3 in prostate cancer cells. J Steroid Biochem Mol Biol. 2003 May;85(1):1-8. doi: 10.1016/s0960-0760(03)00142-0.
932 The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
933 Gene expression profiling of early primary biliary cirrhosis: possible insights into the mechanism of action of ursodeoxycholic acid. Liver Int. 2008 Aug;28(7):997-1010. doi: 10.1111/j.1478-3231.2008.01744.x. Epub 2008 Apr 15.
934 Cdk4/6 inhibition induces epithelial-mesenchymal transition and enhances invasiveness in pancreatic cancer cells. Mol Cancer Ther. 2012 Oct;11(10):2138-48. doi: 10.1158/1535-7163.MCT-12-0562. Epub 2012 Aug 6.
935 Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions. Toxicol In Vitro. 2009 Apr;23(3):466-75. doi: 10.1016/j.tiv.2008.12.018. Epub 2008 Dec 30.
936 Validation of a genotoxicity test based on p53R2 gene expression in human lymphoblastoid cells. Mutat Res. 2011 Sep 18;724(1-2):76-85. doi: 10.1016/j.mrgentox.2011.06.003. Epub 2011 Jun 17.
937 [Expression and function of Ahi-1 gene in Jurkat cells]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009 Apr;17(2):445-9.
938 Computational discovery of niclosamide ethanolamine, a repurposed drug candidate that reduces growth of hepatocellular carcinoma cells initro and in mice by inhibiting cell division cycle 37 signaling. Gastroenterology. 2017 Jun;152(8):2022-2036.
939 Actinomycin D upregulates proapoptotic protein Puma and downregulates Bcl-2 mRNA in normal peripheral blood lymphocytes. Anticancer Drugs. 2007 Aug;18(7):763-72. doi: 10.1097/CAD.0b013e3280adc905.
940 Improved apoptotic cell death in drug-resistant non-small-cell lung cancer cells by tumor necrosis factor-related apoptosis-inducing ligand-based treatment. J Pharmacol Exp Ther. 2014 Mar;348(3):360-71. doi: 10.1124/jpet.113.210054. Epub 2013 Dec 17.
941 Aspirin induces apoptosis in human leukemia cells independently of NF-kappaB and MAPKs through alteration of the Mcl-1/Noxa balance. Apoptosis. 2010 Feb;15(2):219-29. doi: 10.1007/s10495-009-0424-9.
942 Vanadium-induced HB-EGF expression in human lung fibroblasts is oxidant dependent and requires MAP kinases. Am J Physiol Lung Cell Mol Physiol. 2003 May;284(5):L774-82. doi: 10.1152/ajplung.00189.2002. Epub 2003 Jan 10.
943 Osmotic Induction of Angiogenic Growth Factor Expression in Human Retinal Pigment Epithelial Cells. PLoS One. 2016 Jan 22;11(1):e0147312. doi: 10.1371/journal.pone.0147312. eCollection 2016.
944 Oxidative stress modulates KLF6Full and its splice variants. Alcohol Clin Exp Res. 2012 Nov;36(11):1851-62. doi: 10.1111/j.1530-0277.2012.01798.x. Epub 2012 Apr 6.
945 The mitochondrial superoxide/thioredoxin-2/Ask1 signaling pathway is critically involved in troglitazone-induced cell injury to human hepatocytes. Toxicol Sci. 2008 Feb;101(2):341-9. doi: 10.1093/toxsci/kfm273. Epub 2007 Nov 1.
946 Vitamin D3 up-regulated protein 1 mediates oxidative stress via suppressing the thioredoxin function. J Immunol. 2000 Jun 15;164(12):6287-95. doi: 10.4049/jimmunol.164.12.6287.
947 Efavirenz and 8-hydroxyefavirenz induce cell death via a JNK- and BimEL-dependent mechanism in primary human hepatocytes. Toxicol Appl Pharmacol. 2011 Dec 1;257(2):227-34. doi: 10.1016/j.taap.2011.09.008. Epub 2011 Sep 19.
948 Levodopa activates apoptosis signaling kinase 1 (ASK1) and promotes apoptosis in a neuronal model: implications for the treatment of Parkinson's disease. Chem Res Toxicol. 2011 Oct 17;24(10):1644-52. doi: 10.1021/tx200082h. Epub 2011 Aug 22.
949 Expression of NAG-1, a transforming growth factor-beta superfamily member, by troglitazone requires the early growth response gene EGR-1. J Biol Chem. 2004 Feb 20;279(8):6883-92. doi: 10.1074/jbc.M305295200. Epub 2003 Dec 8.
950 Growth differentiation factor 15 production is necessary for normal erythroid differentiation and is increased in refractory anaemia with ring-sideroblasts. Br J Haematol. 2009 Jan;144(2):251-62. doi: 10.1111/j.1365-2141.2008.07441.x. Epub 2008 Nov 19.
951 DNA array analysis of the effects of aspirin on colon cancer cells: involvement of Rac1. Carcinogenesis. 2004 Jul;25(7):1293-8.
952 Acetylation-dependent function of human single-stranded DNA binding protein 1. Nucleic Acids Res. 2015 Sep 18;43(16):7878-87. doi: 10.1093/nar/gkv707. Epub 2015 Jul 13.
953 Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells. J Biol Chem. 2012 Dec 14;287(51):43137-55.
954 Characterization of the Molecular Alterations Induced by the Prolonged Exposure of Normal Colon Mucosa and Colon Cancer Cells to Low-Dose Bisphenol A. Int J Mol Sci. 2022 Oct 1;23(19):11620. doi: 10.3390/ijms231911620.
955 Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.
956 Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens. Food Chem Toxicol. 2009 Apr;47(4):787-95.
957 Genome-wide analysis of BEAS-2B cells exposed to trivalent arsenicals and dimethylthioarsinic acid. Toxicology. 2010 Jan 31;268(1-2):31-9.
958 Polymorphisms of ACE2 gene are associated with essential hypertension and antihypertensive effects of Captopril in women. Clin Pharmacol Ther. 2007 Aug;82(2):187-96. doi: 10.1038/sj.clpt.6100214. Epub 2007 May 2.
959 Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue. Arch Toxicol. 2020 Dec;94(12):4037-4041. doi: 10.1007/s00204-020-02869-1. Epub 2020 Aug 17.
960 Characterization of drug-specific signaling between primary human hepatocytes and immune cells. Toxicol Sci. 2017 Jul 1;158(1):76-89.
961 Mapping the dynamics of Nrf2 antioxidant and NFB inflammatory responses by soft electrophilic chemicals in human liver cells defines the transition from adaptive to adverse responses. Toxicol In Vitro. 2022 Oct;84:105419. doi: 10.1016/j.tiv.2022.105419. Epub 2022 Jun 17.
962 Protein expression profiling identifies molecular targets of quercetin as a major dietary flavonoid in human colon cancer cells. Proteomics. 2004 Jul;4(7):2160-74.
963 Oxidative stress modulates expression of immune checkpoint genes via activation of AhR signaling. Toxicol Appl Pharmacol. 2022 Dec 15;457:116314. doi: 10.1016/j.taap.2022.116314. Epub 2022 Nov 9.
964 Essential role of HDAC6 in the regulation of PD-L1 in?melanoma. Mol Oncol. 2016 May;10(5):735-750. doi: 10.1016/j.molonc.2015.12.012. Epub 2016 Jan 6.
965 Thalidomide suppresses angiogenesis and immune evasion via lncRNA FGD5-AS1/miR-454-3p/ZEB1 axis-mediated VEGFA expression and PD-1/PD-L1 checkpoint in NSCLC. Chem Biol Interact. 2021 Nov 1;349:109652. doi: 10.1016/j.cbi.2021.109652. Epub 2021 Sep 11.
966 CircRNA VIM silence synergizes with sevoflurane to inhibit immune escape and multiple oncogenic activities of esophageal cancer by simultaneously regulating miR-124/PD-L1 axis. Cell Biol Toxicol. 2022 Oct;38(5):825-845. doi: 10.1007/s10565-021-09613-0. Epub 2021 May 20.
967 The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling. Biochemistry. 2009 Nov 3;48(43):10267-74. doi: 10.1021/bi9009677.
968 Isobaric tags for relative and absolute quantitation-based proteomics analysis of the effect of ginger oil on bisphenol A-induced breast cancer cell proliferation. Oncol Lett. 2021 Feb;21(2):101. doi: 10.3892/ol.2020.12362. Epub 2020 Dec 8.
969 AMPK-dependent signaling modulates the suppression of invasion and migration by fenofibrate in CAL 27 oral cancer cells through NF-B pathway. Environ Toxicol. 2016 Jul;31(7):866-76. doi: 10.1002/tox.22097. Epub 2014 Dec 24.
970 p53 hypersensitivity is the predominant mechanism of the unique responsiveness of testicular germ cell tumor (TGCT) cells to cisplatin. PLoS One. 2011 Apr 21;6(4):e19198. doi: 10.1371/journal.pone.0019198.
971 Protective role of HO-1 for alcohol-dependent liver damage. Dig Dis. 2010;28(6):792-8. doi: 10.1159/000324287. Epub 2011 Apr 27.
972 Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease. J Neurosci. 2016 Jun 8;36(23):6332-51. doi: 10.1523/JNEUROSCI.0426-16.2016.
973 P21(Waf1/Cip1) plays a critical role in furazolidone-induced apoptosis in HepG2 cells through influencing the caspase-3 activation and ROS generation. Food Chem Toxicol. 2016 Feb;88:1-12. doi: 10.1016/j.fct.2015.12.004. Epub 2015 Dec 11.
974 Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. J Biol Chem. 2011 Feb 25;286(8):6602-13.
975 Research resource: STR DNA profile and gene expression comparisons of human BG-1 cells and a BG-1/MCF-7 clonal variant. Mol Endocrinol. 2014 Dec;28(12):2072-81.
976 A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system. Toxicol Sci. 2005 Feb;83(2):282-92.
977 Determination of phospholipidosis potential based on gene expression analysis in HepG2 cells. Toxicol Sci. 2007 Mar;96(1):101-14.
978 Oxidative and calcium stress regulate DSCR1 (Adapt78/MCIP1) protein. Free Radic Biol Med. 2003 Sep 1;35(5):528-39. doi: 10.1016/s0891-5849(03)00358-7.
979 Gene expression profile of human lymphoid CEM cells sensitive and resistant to glucocorticoid-evoked apoptosis. Genomics. 2003 Jun;81(6):543-55.
980 PLX4032 Mediated Melanoma Associated Antigen Potentiation in Patient Derived Primary Melanoma Cells. J Cancer. 2015 Oct 29;6(12):1320-30. doi: 10.7150/jca.11126. eCollection 2015.
981 Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297. doi: 10.1016/j.fct.2020.111297. Epub 2020 Mar 28.
982 Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. Arch Toxicol. 2018 Apr;92(4):1453-1469.
983 N-acylation of glucosamine modulates chondrocyte growth, proteoglycan synthesis, and gene expression. J Rheumatol. 2005 Sep;32(9):1775-86.
984 Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathway. Blood. 2006 Apr 15;107(8):3221-8. doi: 10.1182/blood-2005-07-2843. Epub 2005 Dec 15.
985 The psychoactive compound of Cannabis sativa, (9)-tetrahydrocannabinol (THC) inhibits the human trophoblast cell turnover. Toxicology. 2015 Aug 6;334:94-103. doi: 10.1016/j.tox.2015.06.005. Epub 2015 Jun 9.
986 Effects of Bisphenol A on endogenous retroviral envelopes expression and trophoblast fusion in BeWo cells. Reprod Toxicol. 2019 Oct;89:35-44. doi: 10.1016/j.reprotox.2019.07.001. Epub 2019 Jul 3.
987 Differentiation of human placental BeWo cells by the environmental contaminant benzo(a)pyrene. Chem Biol Interact. 2014 Mar 5;210:1-11.
988 Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.
989 Effects of selective serotonin-reuptake inhibitors (SSRIs) on human villous trophoblasts syncytialization. Toxicol Appl Pharmacol. 2018 Jun 15;349:8-20. doi: 10.1016/j.taap.2018.04.018. Epub 2018 Apr 19.
990 Anandamide down-regulates placental transporter expression through CB2 receptor-mediated inhibition of cAMP synthesis. Pharmacol Res. 2019 Mar;141:331-342. doi: 10.1016/j.phrs.2019.01.002. Epub 2019 Jan 2.
991 Gene expression profile analysis of 4-phenylbutyrate treatment of IB3-1 bronchial epithelial cell line demonstrates a major influence on heat-shock proteins. Physiol Genomics. 2004 Jan 15;16(2):204-11.
992 Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics. Sci Rep. 2023 Jun 29;13(1):10519. doi: 10.1038/s41598-023-37488-0.
993 Induction of the endoplasmic reticulum stress protein GADD153/CHOP by capsaicin in prostate PC-3 cells: a microarray study. Biochem Biophys Res Commun. 2008 Aug 8;372(4):785-91.
994 Prenatal arsenic exposure and shifts in the newborn proteome: interindividual differences in tumor necrosis factor (TNF)-responsive signaling. Toxicol Sci. 2014 Jun;139(2):328-37. doi: 10.1093/toxsci/kfu053. Epub 2014 Mar 27.
995 Testosterone or 17{beta}-estradiol exposure reveals sex-specific effects on glucose and lipid metabolism in human myotubes. J Endocrinol. 2011 Aug;210(2):219-29. doi: 10.1530/JOE-10-0497. Epub 2011 Jun 1.
996 Activation of peroxisome proliferator-activated receptor-gamma by rosiglitazone protects human islet cells against human islet amyloid polypeptide toxicity by a phosphatidylinositol 3'-kinase-dependent pathway. J Clin Endocrinol Metab. 2005 Dec;90(12):6678-86. doi: 10.1210/jc.2005-0079. Epub 2005 Oct 4.
997 Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray. Cancer Sci. 2006 Jan;97(1):64-71.
998 Apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma. PLoS One. 2011;6(8):e23569.
999 In vitro detection of drug-induced phospholipidosis using gene expression and fluorescent phospholipid based methodologies. Toxicol Sci. 2007 Sep;99(1):162-73.
1000 Darinaparsin: solid tumor hypoxic cytotoxin and radiosensitizer. Clin Cancer Res. 2012 Jun 15;18(12):3366-76.
1001 Lack of uniform platelet activation in patients after ischemic stroke and choice of antiplatelet therapy. Thromb Res. 2004;113(3-4):197-204. doi: 10.1016/j.thromres.2004.03.002.
1002 Circulating endothelial progenitor cells in multiple myeloma: implications and significance. Blood. 2005 Apr 15;105(8):3286-94. doi: 10.1182/blood-2004-06-2101. Epub 2004 Dec 23.
1003 Identification of biomarkers and outcomes of endocrine disruption in human ovarian cortex using In Vitro Models. Toxicology. 2023 Feb;485:153425. doi: 10.1016/j.tox.2023.153425. Epub 2023 Jan 5.
1004 Frequent inactivation of RAMP2, EFEMP1 and Dutt1 in lung cancer by promoter hypermethylation. Clin Cancer Res. 2007 Aug 1;13(15 Pt 1):4336-44. doi: 10.1158/1078-0432.CCR-07-0015.
1005 Oncoprotein SET dynamically regulates cellular stress response through nucleocytoplasmic transport in breast cancer. Cell Biol Toxicol. 2023 Aug;39(4):1795-1814. doi: 10.1007/s10565-022-09784-4. Epub 2022 Dec 19.
1006 Epigenetic activation of O-linked -N-acetylglucosamine transferase overrides the differentiation blockage in acute leukemia. EBioMedicine. 2020 Apr;54:102678. doi: 10.1016/j.ebiom.2020.102678. Epub 2020 Apr 6.
1007 Short-chain fatty acids enhance nuclear receptor activity through mitogen-activated protein kinase activation and histone deacetylase inhibition. Proc Natl Acad Sci U S A. 2004 May 4;101(18):7199-204.
1008 Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts. Biomed Res Int. 2015;2015:257090. doi: 10.1155/2015/257090. Epub 2015 Aug 3.
1009 Curcumin reduces the expression of survivin, leading to enhancement of arsenic trioxide-induced apoptosis in myelodysplastic syndrome and leukemia stem-like cells. Oncol Rep. 2016 Sep;36(3):1233-42. doi: 10.3892/or.2016.4944. Epub 2016 Jul 15.
1010 Effect of atorvastatin on circulating proinflammatory T-lymphocyte subsets and soluble CD40 ligand in patients with stable coronary artery disease--a randomized, placebo-controlled study. Am Heart J. 2006 Jan;151(1):139. doi: 10.1016/j.ahj.2005.10.006.
1011 Additive beneficial effects of fenofibrate combined with candesartan in the treatment of hypertriglyceridemic hypertensive patients. Diabetes Care. 2006 Feb;29(2):195-201. doi: 10.2337/diacare.29.02.06.dc05-1418.
1012 Eptifibatide in peripheral vascular interventions: results of the Integrilin Reduces Inflammation in Peripheral Vascular Interventions (INFLAME) trial. J Invasive Cardiol. 2006 Jan;18(1):6-12.
1013 Similarities and differences between two modes of antagonism of the thyroid hormone receptor. ACS Chem Biol. 2011 Oct 21;6(10):1096-106.
1014 Targeting the beta-catenin/TCF transcriptional complex in the treatment of multiple myeloma. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7516-21. doi: 10.1073/pnas.0610299104. Epub 2007 Apr 23.
1015 Adaptive changes in global gene expression profile of lung carcinoma A549 cells acutely exposed to distinct types of AhR ligands. Toxicol Lett. 2018 Aug;292:162-174.
1016 RNA sequence analysis of inducible pluripotent stem cell-derived cardiomyocytes reveals altered expression of DNA damage and cell cycle genes in response to doxorubicin. Toxicol Appl Pharmacol. 2018 Oct 1;356:44-53.
1017 Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling. Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21737-42. doi: 10.1073/pnas.1007863107. Epub 2010 Nov 22.
1018 Patterns of some extracellular matrix gene expression are similar in cells from cleft lip-palate patients and in human palatal fibroblasts exposed to diazepam in culture. Toxicology. 2009 Mar 4;257(1-2):10-6. doi: 10.1016/j.tox.2008.12.002. Epub 2008 Dec 9.
1019 Imiquimod: a potential weapon against Dupuytren contracture. Med Hypotheses. 2006;66(5):991-2. doi: 10.1016/j.mehy.2005.09.052. Epub 2005 Dec 20.
1020 The role of simvastatin in the osteogenesis of injectable tissue-engineered bone based on human adipose-derived stromal cells and platelet-rich plasma. Biomaterials. 2010 Jul;31(20):5325-35. doi: 10.1016/j.biomaterials.2010.03.037. Epub 2010 Apr 9.
1021 Proliferation of cultured human gingival fibroblasts caused by isradipine, a dihydropyridine-derivative calcium antagonist. Eur J Med Res. 2004 Jun 30;9(6):313-5.
1022 The effect of valdecoxib on the production of growth factors evoked by hypoxia and bacterial lipopolysaccharide in HMEC-1 cells. Adv Clin Exp Med. 2013 Nov-Dec;22(6):795-800.
1023 Gene expression signatures after ethanol exposure in differentiating embryoid bodies. Toxicol In Vitro. 2018 Feb;46:66-76.
1024 Transcriptional profiling in the human prefrontal cortex: evidence for two activational states associated with cocaine abuse. Pharmacogenomics J. 2003;3(1):27-40.
1025 Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent. Mol Cancer. 2010 Aug 20;9:220.
1026 Dihydromyricetin suppresses tumor growth via downregulation of the EGFR/Akt/survivin signaling pathway. J Biochem Mol Toxicol. 2023 Jun;37(6):e23328. doi: 10.1002/jbt.23328. Epub 2023 Feb 19.
1027 Effect of toll-like receptor 7 and 9 targeted therapy to prevent the development of hepatocellular carcinoma. Liver Int. 2015 Mar;35(3):1063-76. doi: 10.1111/liv.12626. Epub 2014 Jul 30.
1028 Targeting iron homeostasis induces cellular differentiation and synergizes with differentiating agents in acute myeloid leukemia. J Exp Med. 2010 Apr 12;207(4):731-50. doi: 10.1084/jem.20091488. Epub 2010 Apr 5.
1029 Long-term estrogen exposure promotes carcinogen bioactivation, induces persistent changes in gene expression, and enhances the tumorigenicity of MCF-7 human breast cancer cells. Toxicol Appl Pharmacol. 2009 Nov 1;240(3):355-66.
1030 Identification of biomarkers modulated by the rexinoid LGD1069 (bexarotene) in human breast cells using oligonucleotide arrays. Cancer Res. 2006 Dec 15;66(24):12009-18.
1031 Characterization of DOK1, a candidate tumor suppressor gene, in epithelial ovarian cancer. Mol Oncol. 2011 Oct;5(5):438-53. doi: 10.1016/j.molonc.2011.07.003. Epub 2011 Jul 26.
1032 Expression profile analysis of human peripheral blood mononuclear cells in response to aspirin. Arch Immunol Ther Exp (Warsz). 2005 Mar-Apr;53(2):151-8.
1033 Ornithine decarboxylase antizyme upregulates DNA-dependent protein kinase and enhances the nonhomologous end-joining repair of DNA double-strand breaks in human oral cancer cells. Biochemistry. 2007 Aug 7;46(31):8920-32. doi: 10.1021/bi7000328. Epub 2007 Jul 14.
1034 Selective nonsteroidal anti-inflammatory drugs induce thymosin beta-4 and alter actin cytoskeletal organization in human colorectal cancer cells. J Pharmacol Exp Ther. 2004 Dec;311(3):885-91. doi: 10.1124/jpet.104.070664. Epub 2004 Aug 3.
1035 5-Fluorouracil: identification of novel downstream mediators of tumour response. Anticancer Res. 2004 Mar-Apr;24(2A):417-23.
1036 Malathion induced cancer-linked gene expression in human lymphocytes. Environ Res. 2020 Mar;182:109131. doi: 10.1016/j.envres.2020.109131. Epub 2020 Jan 10.
1037 Cellular reactions to long-term volatile organic compound (VOC) exposures. Sci Rep. 2016 Dec 1;6:37842. doi: 10.1038/srep37842.
1038 Effects of Cyanobacterial Harmful Algal Bloom Toxin Microcystin-LR on Gonadotropin-Dependent Ovarian Follicle Maturation and Ovulation in Mice. Environ Health Perspect. 2023 Jun;131(6):67010. doi: 10.1289/EHP12034. Epub 2023 Jun 21.
1039 Effect of all-trans retinoic acid on sodium/iodide symporter expression, radioiodine uptake and gene expression profiles in a human anaplastic thyroid carcinoma cell line. Nucl Med Biol. 2006 Oct;33(7):875-82. doi: 10.1016/j.nucmedbio.2006.07.004.
1040 Nuclear proteome analysis of cisplatin-treated HeLa cells. Mutat Res. 2010 Sep 10;691(1-2):1-8. doi: 10.1016/j.mrfmmm.2010.06.002. Epub 2010 Jun 9.
1041 Human splicing factor SPF45 (RBM17) confers broad multidrug resistance to anticancer drugs when overexpressed--a phenotype partially reversed by selective estrogen receptor modulators. Cancer Res. 2005 Aug 1;65(15):6593-600. doi: 10.1158/0008-5472.CAN-03-3675.
1042 Promotion of the articular cartilage proteoglycan degradation by T-2 toxin and selenium protective effect. J Zhejiang Univ Sci B. 2008 Jan;9(1):22-33. doi: 10.1631/jzus.B071322.
1043 Simvastatin prevents skeletal metastasis of breast cancer by an antagonistic interplay between p53 and CD44. J Biol Chem. 2011 Apr 1;286(13):11314-27. doi: 10.1074/jbc.M110.193714. Epub 2011 Jan 3.
1044 Enhancement of the antiproliferative activity of gemcitabine by modulation of c-Met pathway in pancreatic cancer. Curr Pharm Des. 2013;19(5):940-50.
1045 Mitogen-activated protein kinases pathway is involved in physiological testosterone-induced tissue factor pathway inhibitor expression in endothelial cells. Blood Coagul Fibrinolysis. 2010 Jul;21(5):420-4. doi: 10.1097/MBC.0b013e328337b475.
1046 Aspirin regulates hepatocellular lipid metabolism by activating AMPK signaling pathway. J Toxicol Sci. 2015 Feb;40(1):127-36. doi: 10.2131/jts.40.127.
1047 Organochloride pesticides impaired mitochondrial function in hepatocytes and aggravated disorders of fatty acid metabolism. Sci Rep. 2017 Apr 11;7:46339. doi: 10.1038/srep46339.
1048 Linalool is a PPARalpha ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome. J Lipid Res. 2014 Jun;55(6):1098-110.
1049 Persistent and non-persistent changes in gene expression result from long-term estrogen exposure of MCF-7 breast cancer cells. J Steroid Biochem Mol Biol. 2011 Feb;123(3-5):140-50.
1050 Human drug metabolism genes in parathion-and estrogen-treated breast cells. Int J Mol Med. 2007 Dec;20(6):875-81.
1051 Glutathione-related enzymes contribute to resistance of tumor cells and low toxicity in normal organs to artesunate. In Vivo. 2005 Jan-Feb;19(1):225-32.
1052 Influence of cell cycle on responses of MCF-7 cells to benzo[a]pyrene. BMC Genomics. 2011 Jun 29;12:333.
1053 TGF-1 signaling protects retinal ganglion cells from oxidative stress via modulation of the HO-1/Nrf2 pathway. Chem Biol Interact. 2020 Nov 1;331:109249. doi: 10.1016/j.cbi.2020.109249. Epub 2020 Sep 24.
1054 Evaluation of gene induction of drug-metabolizing enzymes and transporters in primary culture of human hepatocytes using high-sensitivity real-time reverse transcription PCR. Yakugaku Zasshi. 2002 May;122(5):339-61.
1055 New arylpiperazine derivatives as antagonists of the human cloned 5-HT(4) receptor isoforms. J Med Chem. 2000 Oct 5;43(20):3761-9. doi: 10.1021/jm0009538.
1056 Darinaparsin induces a unique cellular response and is active in an arsenic trioxide-resistant myeloma cell line. Mol Cancer Ther. 2009 May;8(5):1197-206.
1057 Gene expression profiling in Ishikawa cells: a fingerprint for estrogen active compounds. Toxicol Appl Pharmacol. 2009 Apr 1;236(1):85-96.
1058 Estrogenic and genotoxic potential of equol and two hydroxylated metabolites of Daidzein in cultured human Ishikawa cells. Toxicol Lett. 2005 Jul 28;158(1):72-86. doi: 10.1016/j.toxlet.2005.02.011. Epub 2005 Apr 11.
1059 Effect of benzo[a]pyrene on proliferation and metastasis of oral squamous cell carcinoma cells: A transcriptome analysis based on RNA-seq. Environ Toxicol. 2022 Nov;37(11):2589-2604. doi: 10.1002/tox.23621. Epub 2022 Jul 23.
1060 Transcriptomic?pathway?and?benchmark dose analysis of Bisphenol A, Bisphenol S, Bisphenol F, and 3,3',5,5'-Tetrabromobisphenol A in H9 human embryonic stem cells. Toxicol In Vitro. 2021 Apr;72:105097. doi: 10.1016/j.tiv.2021.105097. Epub 2021 Jan 18.
1061 High-throughput ectopic expression screen for tamoxifen resistance identifies an atypical kinase that blocks autophagy. Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2058-63.
1062 In Vitro Exposure of Human Luteinized Mural Granulosa Cells to Dibutyl Phthalate Affects Global Gene Expression. Toxicol Sci. 2017 Nov 1;160(1):180-188. doi: 10.1093/toxsci/kfx170.
1063 Downregulation of Organic Anion Transporting Polypeptide (OATP) 1B1 Transport Function by Lysosomotropic Drug Chloroquine: Implication in OATP-Mediated Drug-Drug Interactions. Mol Pharm. 2016 Mar 7;13(3):839-51. doi: 10.1021/acs.molpharmaceut.5b00763. Epub 2016 Feb 1.
1064 Bisphenolic compounds alter gene expression in MCF-7 cells through interaction with estrogen receptor . Toxicol Appl Pharmacol. 2020 Jul 15;399:115030. doi: 10.1016/j.taap.2020.115030. Epub 2020 May 6.
1065 Comprehensive analysis of transcriptomic changes induced by low and high doses of bisphenol A in HepG2 spheroids in vitro and rat liver in vivo. Environ Res. 2019 Jun;173:124-134. doi: 10.1016/j.envres.2019.03.035. Epub 2019 Mar 18.
1066 Monitoring of deiodinase deficiency based on transcriptomic responses in SH-SY5Y cells. Arch Toxicol. 2013 Jun;87(6):1103-13. doi: 10.1007/s00204-013-1018-4. Epub 2013 Feb 10.
1067 Small Molecule Antipsychotic Aripiprazole Potentiates Ozone-Induced Inflammation in Airway Epithelium. Chem Res Toxicol. 2019 Oct 21;32(10):1997-2005. doi: 10.1021/acs.chemrestox.9b00149. Epub 2019 Sep 11.
1068 Stathmin is involved in arsenic trioxide-induced apoptosis in human cervical cancer cell lines via PI3K linked signal pathway. Cancer Biol Ther. 2010 Sep 15;10(6):632-43. doi: 10.4161/cbt.10.6.12654. Epub 2010 Sep 13.
1069 Increased expression of VDAC1 sensitizes carcinoma cells to apoptosis induced by DNA cross-linking agents. Biochem Pharmacol. 2012 May 1;83(9):1172-82. doi: 10.1016/j.bcp.2012.01.017. Epub 2012 Jan 21.
1070 Sulindac-derived reactive oxygen species induce apoptosis of human multiple myeloma cells via p38 mitogen activated protein kinase-induced mitochondrial dysfunction. Apoptosis. 2007 Jan;12(1):195-209. doi: 10.1007/s10495-006-0527-5.
1071 Inhibition of lung cancer cell growth by quercetin glucuronides via G2/M arrest and induction of apoptosis. Drug Metab Dispos. 2006 Feb;34(2):296-304. doi: 10.1124/dmd.105.005280. Epub 2005 Nov 9.
1072 Levamisole induced apoptosis in cultured vascular endothelial cells. Br J Pharmacol. 2000 Dec;131(8):1577-83.
1073 Arsenic trioxide (As(2)O(3)) induced apoptosis and its mechanisms in a human esophageal squamous carcinoma cell line. Chin Med J (Engl). 2002 Feb;115(2):280-5.
1074 Non-steroidal anti-inflammatory drugs induce apoptosis in gastric cancer cells through up-regulation of bax and bak. Carcinogenesis. 2001 Sep;22(9):1393-7. doi: 10.1093/carcin/22.9.1393.
1075 AMPK activation induced by promethazine increases NOXA expression and Beclin-1 phosphorylation and drives autophagy-associated apoptosis in chronic myeloid leukemia. Chem Biol Interact. 2020 Jan 5;315:108888. doi: 10.1016/j.cbi.2019.108888. Epub 2019 Nov 2.
1076 Genomic and proteomic profiling of responses to toxic metals in human lung cells. Environ Health Perspect. 2003 May;111(6):825-35.
1077 Co-Administration of Melatonin Effectively Enhances the Therapeutic Effects of Pioglitazone on Mesenchymal Stem Cells Undergoing Indoxyl Sulfate-Induced Senescence through Modulation of Cellular Prion Protein Expression. Int J Mol Sci. 2018 May 4;19(5):1367. doi: 10.3390/ijms19051367.
1078 A systems biology understanding of the synergistic effects of arsenic sulfide and Imatinib in BCR/ABL-associated leukemia. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3378-83.
1079 Bisphenol A and bisphenol S induce distinct transcriptional profiles in differentiating human primary preadipocytes. PLoS One. 2016 Sep 29;11(9):e0163318.
1080 Cisplatin induces autophagy to enhance hepatitis B virus replication via activation of ROS/JNK and inhibition of the Akt/mTOR pathway. Free Radic Biol Med. 2019 Feb 1;131:225-236. doi: 10.1016/j.freeradbiomed.2018.12.008. Epub 2018 Dec 11.
1081 Inhibition of autophagic flux differently modulates cannabidiol-induced death in 2D and 3D glioblastoma cell cultures. Sci Rep. 2020 Feb 14;10(1):2687. doi: 10.1038/s41598-020-59468-4.
1082 Frankincense myrrh attenuates hepatocellular carcinoma by regulating tumor blood vessel development through multiple epidermal growth factor receptor-mediated signaling pathways. World J Gastrointest Oncol. 2022 Feb 15;14(2):450-477. doi: 10.4251/wjgo.v14.i2.450.
1083 Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cells. J Biol Chem. 2002 Nov 15;277(46):43648-58. doi: 10.1074/jbc.M203214200. Epub 2002 Sep 6.
1084 Lon protease and eiF2 are involved in acute, but not prolonged, antiretroviral induced stress response in HepG2 cells. Chem Biol Interact. 2016 May 25;252:82-6. doi: 10.1016/j.cbi.2016.03.021. Epub 2016 Apr 1.
1085 Disease-modifying effects of glucosamine HCl involving regulation of metalloproteinases and chemokines activated by interleukin-1beta in human primary synovial fibroblasts. J Cell Biochem. 2008 May 1;104(1):38-50. doi: 10.1002/jcb.21597.
1086 Characterization of cell death induced by ethacrynic acid in a human colon cancer cell line DLD-1 and suppression by N-acetyl-L-cysteine. Cancer Sci. 2003 Oct;94(10):886-93.
1087 [Induced RAS association domain family gene 1A gene expression by arsenic trioxide in nasopharyngeal carcinoma cell]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2009 Oct;44(10):866-70.
1088 Tumor suppressor gene inactivation during cadmium-induced malignant transformation of human prostate cells correlates with overexpression of de novo DNA methyltransferase. Environ Health Perspect. 2007 Oct;115(10):1454-9. doi: 10.1289/ehp.10207.
1089 The effect of dietary polyphenols on the epigenetic regulation of gene expression in MCF7 breast cancer cells. Toxicol Lett. 2010 Feb 1;192(2):119-25.
1090 Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNF-mediated hepatotoxicity. Toxicol Sci. 2014 Jul;140(1):144-59. doi: 10.1093/toxsci/kfu072. Epub 2014 Apr 20.
1091 Mechanism of cisplatin proximal tubule toxicity revealed by integrating transcriptomics, proteomics, metabolomics and biokinetics. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):117-27.
1092 Evaluation of early biomarkers of muscle anabolic response to testosterone. J Cachexia Sarcopenia Muscle. 2011 Mar;2(1):45-56. doi: 10.1007/s13539-011-0021-y. Epub 2011 Feb 26.
1093 Nrf2 but not autophagy inhibition is associated with the survival of wild-type epidermal growth factor receptor non-small cell lung cancer cells. Toxicol Appl Pharmacol. 2016 Nov 1;310:140-149. doi: 10.1016/j.taap.2016.09.010. Epub 2016 Sep 14.
1094 Hydroquinone triggers pyroptosis and endoplasmic reticulum stress via AhR-regulated oxidative stress in human lymphocytes. Toxicol Lett. 2023 Mar 1;376:39-50. doi: 10.1016/j.toxlet.2023.01.005. Epub 2023 Jan 13.
1095 A genomic approach to predict synergistic combinations for breast cancer treatment. Pharmacogenomics J. 2013 Feb;13(1):94-104. doi: 10.1038/tpj.2011.48. Epub 2011 Nov 15.
1096 A prominent elevation of glial fibrillary acidic protein in the cerebrospinal fluid during relapse in neuromyelitis optica. Tohoku J Exp Med. 2008 May;215(1):55-9. doi: 10.1620/tjem.215.55.
1097 Histamine H4 receptor agonists have more activities than H4 agonism in antigen-specific human T-cell responses. Immunology. 2007 Jun;121(2):266-75. doi: 10.1111/j.1365-2567.2007.02574.x. Epub 2007 Mar 7.
1098 Resveratrol potentiates effect of simvastatin on inhibition of mevalonate pathway in human endometrial stromal cells. J Clin Endocrinol Metab. 2013 Mar;98(3):E455-62.
1099 Pravastatin inhibited the cholesterol synthesis in human hepatoma cell line Hep G2 less than simvastatin and lovastatin, which is reflected in the upregulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and squalene synthase. Biochem Pharmacol. 1993 Jun 9;45(11):2203-8.
1100 Tumor necrosis factor-alpha-induced protein 3 as a putative regulator of nuclear factor-kappaB-mediated resistance to O6-alkylating agents in human glioblastomas. J Clin Oncol. 2006 Jan 10;24(2):274-87. doi: 10.1200/JCO.2005.02.9405. Epub 2005 Dec 19.
1101 2,3,7,8-tetrachlorodibenzo-p-dioxin augments the modulation of gene expression mediated by the thyroid hormone receptor. Toxicol Appl Pharmacol. 2004 Feb 1;194(3):201-10. doi: 10.1016/j.taap.2003.09.010.
1102 Differential effects of omega-3 and omega-6 Fatty acids on gene expression in breast cancer cells. Breast Cancer Res Treat. 2007 Jan;101(1):7-16. doi: 10.1007/s10549-006-9269-x. Epub 2006 Jul 6.
1103 Pharmacogenomic identification of novel determinants of response to chemotherapy in colon cancer. Cancer Res. 2006 Mar 1;66(5):2765-77.
1104 Identification of troglitazone responsive genes: induction of RTP801 during troglitazone-induced apoptosis in Hep 3B cells. BMB Rep. 2010 Sep;43(9):599-603. doi: 10.5483/BMBRep.2010.43.9.599.
1105 p21(WAF1/cip1) is an important determinant of intestinal cell response to sulindac in vitro and in vivo. Cancer Res. 2001 Aug 15;61(16):6297-302.
1106 The DNA demethylating agent 5-aza-2'-deoxycytidine activates NY-ESO-1 antigenicity in orthotopic human glioma. Int J Cancer. 2008 Jun 1;122(11):2542-53. doi: 10.1002/ijc.23407.
1107 Gene expression profile analysis of gallic acid-induced cell death process. Sci Rep. 2021 Aug 18;11(1):16743. doi: 10.1038/s41598-021-96174-1.
1108 [Effects of bortezomib alone or combined with arsenic trioxide on the apoptosis of Jurkat cells and expression of livin mRNA]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2011 Aug;19(4):898-901.
1109 Molecular mechanism of action of bisphenol and bisphenol A mediated by oestrogen receptor alpha in growth and apoptosis of breast cancer cells. Br J Pharmacol. 2013 May;169(1):167-78.
1110 Rapid induction of IAP family proteins and Smac/DIABLO expression after proapoptotic stimulation with doxorubicin in RPMI 8226 multiple myeloma cells. Exp Mol Pathol. 2007 Dec;83(3):405-12. doi: 10.1016/j.yexmp.2007.04.001. Epub 2007 Apr 18.
1111 Targeted inhibition of Livin resensitizes renal cancer cells towards apoptosis. Cell Mol Life Sci. 2007 May;64(9):1137-44. doi: 10.1007/s00018-007-6510-7.
1112 Resveratrol at anti-angiogenesis/anticancer concentrations suppresses protein kinase G signaling and decreases IAPs expression in HUVECs. Anticancer Res. 2015 Jan;35(1):273-81.
1113 Effect of nephrotoxicants and hepatotoxicants on gene expression profile in human peripheral blood mononuclear cells. Biochem Biophys Res Commun. 2010 Oct 15;401(2):245-50. doi: 10.1016/j.bbrc.2010.09.039. Epub 2010 Sep 16.
1114 Promoter hypermethylation of the RUNX3 gene in esophageal squamous cell carcinoma. Cancer Invest. 2007 Dec;25(8):685-90. doi: 10.1080/07357900701561131.
1115 S100P is selectively upregulated in tumor cell lines challenged with DNA cross-linking agents. Leuk Res. 2005 Oct;29(10):1181-90. doi: 10.1016/j.leukres.2005.03.012.
1116 Using a customized DNA microarray for expression profiling of the estrogen-responsive genes to evaluate estrogen activity among natural estrogens and industrial chemicals. Environ Health Perspect. 2004 May;112(7):773-81. doi: 10.1289/ehp.6753.
1117 Extracellular ATP drives breast cancer cell migration and metastasis via S100A4 production by cancer cells and fibroblasts. Cancer Lett. 2018 Aug 28;430:1-10. doi: 10.1016/j.canlet.2018.04.043. Epub 2018 May 5.
1118 Investigation of in vitro odonto/osteogenic capacity of cannabidiol on human dental pulp cell. J Dent. 2021 Jun;109:103673. doi: 10.1016/j.jdent.2021.103673. Epub 2021 Apr 16.
1119 Chronic senescent human mesenchymal stem cells as possible contributor to the wound healing disorder after exposure to the alkylating agent sulfur mustard. Arch Toxicol. 2021 Feb;95(2):727-747. doi: 10.1007/s00204-020-02946-5. Epub 2021 Jan 25.
1120 Statin-mediated reduction of osteopontin expression induces apoptosis and cell growth arrest in ovarian clear cell carcinoma. Oncol Rep. 2011 Jan;25(1):41-7.
1121 Troglitazone, a PPARgamma ligand, inhibits osteopontin gene expression in human monocytes/macrophage THP-1 cells. J Atheroscler Thromb. 2000;7(2):77-82. doi: 10.5551/jat1994.7.77.
1122 Gene microarray analysis of human renal cell carcinoma: the effects of HDAC inhibition and retinoid treatment. Cancer Biol Ther. 2008 Oct;7(10):1607-18.
1123 Chemical modifications of alpha1,6-fucosyltransferase define amino acid residues of catalytic importance. Biochimie. 2003 Mar-Apr;85(3-4):303-10. doi: 10.1016/s0300-9084(03)00074-9.
1124 Antineoplastic effects of gamma linolenic Acid on hepatocellular carcinoma cell lines. J Clin Biochem Nutr. 2010 Jul;47(1):81-90.
1125 Inorganic arsenic exposure promotes malignant progression by HDAC6-mediated down-regulation of HTRA1. J Appl Toxicol. 2023 Aug;43(8):1214-1224. doi: 10.1002/jat.4457. Epub 2023 Mar 11.
1126 Effects of acute ethanol treatment on NCCIT cells and NCCIT cell-derived embryoid bodies (EBs). Toxicol In Vitro. 2010 Sep;24(6):1696-704. doi: 10.1016/j.tiv.2010.05.017. Epub 2010 May 26.
1127 Bortezomib induces caspase-dependent apoptosis in Hodgkin lymphoma cell lines and is associated with reduced c-FLIP expression: a gene expression profiling study with implications for potential combination therapies. Leuk Res. 2008 Feb;32(2):275-85. doi: 10.1016/j.leukres.2007.05.024. Epub 2007 Jul 19.
1128 Propofol suppresses proliferation, migration, invasion, and tumor growth of liver cancer cells via suppressing cancer susceptibility candidate 9/phosphatase and tensin homolog/AKT serine/threonine kinase/mechanistic target of rapamycin kinase axis. Hum Exp Toxicol. 2022 Jan-Dec;41:9603271211065972. doi: 10.1177/09603271211065972.
1129 Proteomic profile of aminoglutethimide-induced apoptosis in HL-60 cells: role of myeloperoxidase and arylamine free radicals. Chem Biol Interact. 2015 Sep 5;239:129-38.
1130 Regulation of a highly specific retinoic acid-4-hydroxylase (CYP26A1) enzyme and all-trans-retinoic acid metabolism in human intestinal, liver, endothelial, and acute promyelocytic leukemia cells. Leuk Lymphoma. 2005 Oct;46(10):1497-506.
1131 Beta-Carotene conversion into vitamin A in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2005 Oct;46(10):3562-9.
1132 Vitamin D3 transactivates the zinc and manganese transporter SLC30A10 via the Vitamin D receptor. J Steroid Biochem Mol Biol. 2016 Oct;163:77-87.
1133 Dolutegravir Impairs Stem Cell-Based 3D Morphogenesis Models in a Manner Dependent on Dose and Timing of Exposure: An Implication for Its Developmental Toxicity. Toxicol Sci. 2021 Nov 24;184(2):191-203. doi: 10.1093/toxsci/kfab112.
1134 Estrogen receptor alpha (ER)-mediated coregulator binding and gene expression discriminates the toxic ER agonist diethylstilbestrol (DES) from the endogenous ER agonist 17-estradiol (E2). Cell Biol Toxicol. 2020 Oct;36(5):417-435. doi: 10.1007/s10565-020-09516-6. Epub 2020 Feb 22.
1135 The effects of dasatinib on IgE receptor-dependent activation and histamine release in human basophils. Blood. 2008 Mar 15;111(6):3097-107.
1136 Positive signaling interactions between arsenic and ethanol for angiogenic gene induction in human microvascular endothelial cells. Toxicol Sci. 2008 Apr;102(2):319-27. doi: 10.1093/toxsci/kfn003. Epub 2008 Jan 8.
1137 Aberrantly expressed genes in HaCaT keratinocytes chronically exposed to arsenic trioxide. Biomark Insights. 2011 Feb 8;6:7-16.
1138 Oxidative stress-induced epigenetic changes associated with malignant transformation of human kidney epithelial cells. Oncotarget. 2017 Feb 14;8(7):11127-11143. doi: 10.18632/oncotarget.12091.
1139 Comparative effects of retinoic acid, vitamin D and resveratrol alone and in combination with adenosine analogues on methylation and expression of phosphatase and tensin homologue tumour suppressor gene in breast cancer cells. Br J Nutr. 2012 Mar;107(6):781-90. doi: 10.1017/S0007114511003631. Epub 2011 Aug 1.
1140 The low-toxicity 9-cis UAB30 novel retinoid down-regulates the DNA methyltransferases and has anti-telomerase activity in human breast cancer cells. Int J Oncol. 2007 Mar;30(3):641-50.
1141 Cyclophosphamide perturbs cytosine methylation in Jurkat-T cells through LSD1-mediated stabilization of DNMT1 protein. Chem Res Toxicol. 2011 Nov 21;24(11):2040-3. doi: 10.1021/tx2003849. Epub 2011 Nov 1.
1142 DNA methyltransferase inhibitors coordinately induce expression of the human reelin and glutamic acid decarboxylase 67 genes. Mol Pharmacol. 2007 Mar;71(3):644-53. doi: 10.1124/mol.106.030635. Epub 2006 Oct 25.
1143 Arsenic trioxide inhibits DNA methyltransferase and restores methylation-silenced genes in human liver cancer cells. Hum Pathol. 2006 Mar;37(3):298-311.
1144 Hypomethylation mediated by decreased DNMTs involves in the activation of proto-oncogene MPL in TK6 cells treated with hydroquinone. Toxicol Lett. 2012 Mar 25;209(3):239-45. doi: 10.1016/j.toxlet.2011.12.020. Epub 2012 Jan 8.
1145 Activation of peroxisome proliferator-activated receptor-gamma by troglitazone (TGZ) inhibits human lung cell growth. J Cell Biochem. 2005 Nov 1;96(4):760-74. doi: 10.1002/jcb.20474.
1146 Niclosamide overcomes acquired resistance to erlotinib through suppression of STAT3 in non-small cell lung cancer. Mol Cancer Ther. 2013 Oct;12(10):2200-12. doi: 10.1158/1535-7163.MCT-13-0095. Epub 2013 Jul 26.
1147 Effects of different sources of copper on Ctr1, ATP7A, ATP7B, MT and DMT1 protein and gene expression in Caco-2 cells. J Trace Elem Med Biol. 2014 Jul;28(3):344-50.
1148 Hormonal regulation of the Menkes and Wilson copper-transporting ATPases in human placental Jeg-3 cells. Biochem J. 2007 Mar 1;402(2):241-50. doi: 10.1042/BJ20061099.
1149 Copper-transporting P-type ATPase, ATP7A, confers multidrug resistance and its expression is related to resistance to SN-38 in clinical colon cancer. Cancer Res. 2007 May 15;67(10):4860-8. doi: 10.1158/0008-5472.CAN-06-3096.
1150 Copper-transporting P-type adenosine triphosphatase (ATP7A) is associated with platinum-resistance in non-small cell lung cancer (NSCLC). J Transl Med. 2012 Feb 3;10:21. doi: 10.1186/1479-5876-10-21.
1151 Impact of selective serotonin reuptake inhibitors on neural crest stem cell formation. Toxicol Lett. 2017 Nov 5;281:20-25. doi: 10.1016/j.toxlet.2017.08.012. Epub 2017 Aug 24.
1152 Activation of PPAR and inhibition of cell proliferation reduces key proteins associated with the basal subtype of bladder cancer in As3+-transformed UROtsa cells. PLoS One. 2020 Aug 21;15(8):e0237976. doi: 10.1371/journal.pone.0237976. eCollection 2020.
1153 Constitutive gene expression predisposes morphogen-mediated cell fate responses of NT2/D1 and 27X-1 human embryonal carcinoma cells. Stem Cells. 2007 Mar;25(3):771-8. doi: 10.1634/stemcells.2006-0271. Epub 2006 Nov 30.
1154 Mitomycin C induces apoptosis in a caspases-dependent and Fas/CD95-independent manner in human gastric adenocarcinoma cells. Cancer Lett. 2000 Oct 1;158(2):125-32. doi: 10.1016/s0304-3835(00)00489-4.
1155 Protein kinase Czeta abrogates the proapoptotic function of Bax through phosphorylation. J Biol Chem. 2007 Jul 20;282(29):21268-77. doi: 10.1074/jbc.M701613200. Epub 2007 May 24.
1156 An approach to elucidate potential mechanism of renal toxicity of arsenic trioxide. Exp Hematol. 2007 Feb;35(2):252-62.
1157 Folate deficiency in normal human fibroblasts leads to altered expression of genes primarily linked to cell signaling, the cytoskeleton and extracellular matrix. J Nutr Biochem. 2007 Aug;18(8):541-52. doi: 10.1016/j.jnutbio.2006.11.002. Epub 2007 Feb 22.
1158 Isoproterenol effects evaluated in heart slices of human and rat in comparison to rat heart in vivo. Toxicol Appl Pharmacol. 2014 Jan 15;274(2):302-12.
1159 Quercetin induced cell apoptosis and altered gene expression in AGS human gastric cancer cells. Environ Toxicol. 2018 Nov;33(11):1168-1181. doi: 10.1002/tox.22623. Epub 2018 Aug 27.
1160 Gene expression profile induced by arsenic trioxide in chronic lymphocytic leukemia cells reveals a central role for heme oxygenase-1 in apoptosis and regulation of matrix metalloproteinase-9. Oncotarget. 2016 Dec 13;7(50):83359-83377.
1161 Toxicoproteomics reveals an effect of clozapine on autophagy in human liver spheroids. Toxicol Mech Methods. 2023 Jun;33(5):401-410. doi: 10.1080/15376516.2022.2156005. Epub 2022 Dec 19.
1162 Histamine up-regulates phosphodiesterase 4 activity and reduces prostaglandin E2-inhibitory effects in human neutrophils. Inflamm Res. 2000 Nov;49(11):600-9. doi: 10.1007/s000110050637.
1163 CRISPR/Cas9-mediated gene knockout screens and target identification via whole-genome sequencing uncover host genes required for picornavirus infection. J Biol Chem. 2017 Jun 23;292(25):10664-10671. doi: 10.1074/jbc.M117.782425. Epub 2017 Apr 26.
1164 Delivery method, target gene structure, and growth properties of target cells impact mutagenic responses to reactive nitrogen and oxygen species. Chem Res Toxicol. 2012 Apr 16;25(4):873-83. doi: 10.1021/tx2004882. Epub 2012 Feb 21.
1165 Genotoxicity of 3'-azido-3'-deoxythymidine in the human lymphoblastoid cell line, TK6: relationships between DNA incorporation, mutant frequency, and spectrum of deletion mutations in HPRT. Mutat Res. 1999 Oct 19;429(2):249-59. doi: 10.1016/s0027-5107(99)00111-6.
1166 An evaluation of myeloperoxidase-mediated bio-activation of NSAIDs in promyelocytic leukemia (HL-60) cells for potential cytotoxic selectivity. Toxicol Lett. 2017 Oct 5;280:48-56.
1167 Differentiation between stoichiometric and anticatalytic antioxidant properties of benzoic acid analogues: a structure/redox potential relationship study. Chem Biol Interact. 2013 Nov 25;206(2):194-203.
1168 Suppression of RAGE as a basis of simvastatin-dependent plaque stabilization in type 2 diabetes. Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2716-23.
1169 Effect of anti-rheumatic drugs on the release of lysosomal enzymes from human leukocytes. Z Rheumatol. 1984 Jan-Feb;43(1):23-6.
1170 Benzodithiophenes induce differentiation and apoptosis in human leukemia cells. Cancer Res. 2005 Sep 1;65(17):7847-55. doi: 10.1158/0008-5472.CAN-05-1053.
1171 Inhibition of oxidation activity of myeloperoxidase (MPO) by propylthiouracil (PTU) and anti-MPO antibodies from patients with PTU-induced vasculitis. Clin Immunol. 2007 Feb;122(2):187-93. doi: 10.1016/j.clim.2006.09.011. Epub 2006 Oct 27.
1172 Simulation of interindividual differences in inactivation of reactive para-benzoquinone imine metabolites of diclofenac by glutathione S-transferases in human liver cytosol. Toxicol Lett. 2016 Jul 25;255:52-62.
1173 The redox state of cytochrome c modulates resistance to methotrexate in human MCF7 breast cancer cells. PLoS One. 2013 May 13;8(5):e63276. doi: 10.1371/journal.pone.0063276. Print 2013.
1174 Astaxanthin protects mesenchymal stem cells from oxidative stress by direct scavenging of free radicals and modulation of cell signaling. Chem Biol Interact. 2021 Jan 5;333:109324. doi: 10.1016/j.cbi.2020.109324. Epub 2020 Nov 17.
1175 Arsenic trioxide inhibits the proliferation of myeloma cell line through notch signaling pathway. Cancer Cell Int. 2013 Mar 13;13(1):25. doi: 10.1186/1475-2867-13-25.
1176 Mechanism of thalidomide to enhance cytotoxicity of temozolomide in U251-MG glioma cells in vitro. Chin Med J (Engl). 2009 Jun 5;122(11):1260-6.
1177 Effects of theophylline, dexamethasone and salbutamol on cytokine gene expression in human peripheral blood CD4+ T-cells. Eur Respir J. 1999 Nov;14(5):1106-12. doi: 10.1183/09031936.99.14511069.
1178 Cannabidiol selectively modulates interleukin (IL)-1 and IL-6 production in toll-like receptor activated human peripheral blood monocytes. Toxicology. 2021 Dec;464:153016. doi: 10.1016/j.tox.2021.153016. Epub 2021 Nov 2.
1179 Anti-mycotics suppress interleukin-4 and interleukin-5 production in anti-CD3 plus anti-CD28-stimulated T cells from patients with atopic dermatitis. J Invest Dermatol. 2001 Dec;117(6):1635-46. doi: 10.1046/j.0022-202x.2001.01566.x.
1180 Ribavirin polarizes human T cell responses towards a Type 1 cytokine profile. J Hepatol. 1999 Mar;30(3):376-82. doi: 10.1016/s0168-8278(99)80093-2.
1181 Selective inhibition of interleukin-4 gene expression in human T cells by aspirin. Blood. 2001 Mar 15;97(6):1742-9. doi: 10.1182/blood.v97.6.1742.
1182 Immune responses in autoimmune hepatitis: effect of prednisone and azathioprine treatment: case report. Int J Med Sci. 2009 Jun 30;6(4):177-83. doi: 10.7150/ijms.6.177.
1183 Differential effects of three antibiotics on T helper cell cytokine expression. J Antimicrob Chemother. 2005 Sep;56(3):502-6. doi: 10.1093/jac/dki251. Epub 2005 Jul 8.
1184 Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes. J Immunol. 2008 May 15;180(10):6988-96. doi: 10.4049/jimmunol.180.10.6988.
1185 Paradoxical immunologic effects of 2-CdA therapy: comment on the article by Davis et al. Arthritis Rheum. 1998 Sep;41(9):1704-5. doi: 10.1002/1529-0131(199809)41:9<1704::AID-ART26>3.0.CO;2-9.
1186 Induction of APOBEC3C Facilitates the Genotoxic Stress-Mediated Cytotoxicity of Artesunate. Chem Res Toxicol. 2019 Dec 16;32(12):2526-2537. doi: 10.1021/acs.chemrestox.9b00358. Epub 2019 Nov 11.
1187 Molecular characterization of a toxicological tipping point during human stem cell differentiation. Reprod Toxicol. 2020 Jan;91:1-13. doi: 10.1016/j.reprotox.2019.10.001. Epub 2019 Oct 7.
1188 Time-series analysis in imatinib-resistant chronic myeloid leukemia K562-cells under different drug treatments. J Huazhong Univ Sci Technolog Med Sci. 2017 Aug;37(4):621-627. doi: 10.1007/s11596-017-1781-1. Epub 2017 Aug 8.
1189 Convergent transcriptional profiles induced by endogenous estrogen and distinct xenoestrogens in breast cancer cells. Carcinogenesis. 2006 Aug;27(8):1567-78.
1190 Mitochondrial proteomics investigation of a cellular model of impaired dopamine homeostasis, an early step in Parkinson's disease pathogenesis. Mol Biosyst. 2014 Jun;10(6):1332-44.
1191 Dexamethasone controls aryl hydrocarbon receptor (AhR)-mediated CYP1A1 and CYP1A2 expression and activity in primary cultures of human hepatocytes. Chem Biol Interact. 2009 May 15;179(2-3):288-96.
1192 Expression of the retinoic acid-metabolizing enzyme CYP26A1 limits programmed cell death. Mol Pharmacol. 2005 May;67(5):1808-17. doi: 10.1124/mol.104.005769. Epub 2005 Feb 9.
1193 Role of BAX in the apoptotic response to anticancer agents. Science. 2000 Nov 3;290(5493):989-92. doi: 10.1126/science.290.5493.989.
1194 Factors determining sensitivity or resistance of tumor cell lines towards artesunate. Chem Biol Interact. 2010 Apr 15;185(1):42-52.
1195 Regulation of multidrug resistance by ribosomal protein l6 in gastric cancer cells. Cancer Biol Ther. 2005 Feb;4(2):242-7. doi: 10.4161/cbt.4.2.1477. Epub 2005 Feb 20.
1196 Downregulation of TSLC1 and DAL-1 expression occurs frequently in breast cancer. Breast Cancer Res Treat. 2007 Jul;103(3):283-91. doi: 10.1007/s10549-006-9377-7. Epub 2007 Jan 27.
1197 Glutathione-S-transferase genotypes and the adverse effects of azathioprine in young patients with inflammatory bowel disease. Inflamm Bowel Dis. 2007 Jan;13(1):57-64. doi: 10.1002/ibd.20004.
1198 Association of polymorphism in alcohol dehydrogenase and interaction with other genetic risk factors with alcoholic liver cirrhosis. Drug Alcohol Depend. 2010 Jun 1;109(1-3):190-7. doi: 10.1016/j.drugalcdep.2010.01.010. Epub 2010 Feb 18.
1199 Inhibition of human glutathione S-transferases by dopamine, alpha-methyldopa and their 5-S-glutathionyl conjugates. Chem Biol Interact. 1994 Jan;90(1):87-99.
1200 Survival of retinal pigment epithelium after exposure to prolonged oxidative injury: a detailed gene expression and cellular analysis. Invest Ophthalmol Vis Sci. 2004 Oct;45(10):3767-77.
1201 Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta. Mol Biol Cell. 2004 Mar;15(3):1262-72. doi: 10.1091/mbc.e03-06-0360. Epub 2003 Dec 29.
1202 The impact of luteal phase support on gene expression of extracellular matrix protein and adhesion molecules in the human endometrium during the window of implantation following controlled ovarian stimulation with a GnRH antagonist protocol. Fertil Steril. 2010 Nov;94(6):2264-71. doi: 10.1016/j.fertnstert.2010.01.068. Epub 2010 Mar 12.
1203 Primary Human Hepatocyte Spheroids as Tools to Study the Hepatotoxic Potential of Non-Pharmaceutical Chemicals. Int J Mol Sci. 2021 Oct 12;22(20):11005. doi: 10.3390/ijms222011005.
1204 Microarray-based detection and expression analysis of extracellular matrix proteins in drug?resistant ovarian cancer cell lines. Oncol Rep. 2014 Nov;32(5):1981-90. doi: 10.3892/or.2014.3468. Epub 2014 Sep 9.
1205 Protective effects of hepatocyte growth factor gene overexpression against hydrogen peroxide-induced apoptosis in mesenchymal stem cells. Environ Toxicol. 2019 Nov;34(11):1236-1245. doi: 10.1002/tox.22824. Epub 2019 Jul 16.
1206 Clozapine induces oxidative stress and proapoptotic gene expression in neutrophils of schizophrenic patients. J Clin Psychopharmacol. 2005 Oct;25(5):419-26. doi: 10.1097/01.jcp.0000177668.42640.fe.
1207 ATR, PML, and CHK2 play a role in arsenic trioxide-induced apoptosis. J Biol Chem. 2006 Sep 29;281(39):28764-71. doi: 10.1074/jbc.M604392200. Epub 2006 Aug 3.
1208 Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication. J Biol Chem. 2012 Apr 20;287(17):14289-300. doi: 10.1074/jbc.M112.353201. Epub 2012 Mar 1.
1209 Development and validation of the TGx-HDACi transcriptomic biomarker to detect histone deacetylase inhibitors in human TK6 cells. Arch Toxicol. 2021 May;95(5):1631-1645. doi: 10.1007/s00204-021-03014-2. Epub 2021 Mar 26.
1210 Endometrial receptivity is affected in women with high circulating progesterone levels at the end of the follicular phase: a functional genomics analysis. Hum Reprod. 2011 Jul;26(7):1813-25.
1211 Gene expression profiling identifies activating transcription factor 3 as a novel contributor to the proapoptotic effect of curcumin. Mol Cancer Ther. 2005 Feb;4(2):233-41.
1212 Alternatives for the worse: Molecular insights into adverse effects of bisphenol a and substitutes during human adipocyte differentiation. Environ Int. 2021 Nov;156:106730. doi: 10.1016/j.envint.2021.106730. Epub 2021 Jun 27.
1213 Taurine-responsive genes related to signal transduction as identified by cDNA microarray analyses of HepG2 cells. J Med Food. 2006 Spring;9(1):33-41. doi: 10.1089/jmf.2006.9.33.
1214 Steroid and xenobiotic receptor-mediated effects of bisphenol A on human osteoblasts. Life Sci. 2016 Jun 15;155:29-35.
1215 Novel carbocyclic curcumin analog CUR3d modulates genes involved in multiple apoptosis pathways in human hepatocellular carcinoma cells. Chem Biol Interact. 2015 Dec 5;242:107-22.
1216 Resistance in vitro to low-dose aspirin is associated with platelet PlA1 (GP IIIa) polymorphism but not with C807T(GP Ia/IIa) and C-5T Kozak (GP Ibalpha) polymorphisms. J Am Coll Cardiol. 2003 Sep 17;42(6):1115-9. doi: 10.1016/s0735-1097(03)00921-5.
1217 Pro-apoptotic role of integrin 3 in glioma cells. J Neurochem. 2011 May;117(3):494-503. doi: 10.1111/j.1471-4159.2011.07219.x. Epub 2011 Mar 15.
1218 In vitro dual effect of arsenic trioxide on hemopoiesis: inhibition of erythropoiesis and stimulation of megakaryocytic maturation. Blood Cells Mol Dis. 2006 Jan-Feb;36(1):59-76. doi: 10.1016/j.bcmd.2005.10.005. Epub 2005 Dec 15.
1219 Grouping of histone deacetylase inhibitors and other toxicants disturbing neural crest migration by transcriptional profiling. Neurotoxicology. 2015 Sep;50:56-70.
1220 All-trans-retinoic acid inhibits collapsin response mediator protein-2 transcriptional activity during SH-SY5Y neuroblastoma cell differentiation. FEBS J. 2007 Jan;274(2):498-511. doi: 10.1111/j.1742-4658.2006.05597.x.
1221 [Impact of arsenic trioxide on proliferation and metastasis of drug-resistant human ovarian carcinoma cell line]. Ai Zheng. 2002 Aug;21(8):863-7.
1222 Biological specificity of CDK4/6 inhibitors: dose response relationship, in vivo signaling, and composite response signature. Oncotarget. 2017 Jul 4;8(27):43678-43691. doi: 10.18632/oncotarget.18435.
1223 IGF2BP1 induces neuroblastoma via a druggable feedforward loop with MYCN promoting 17q oncogene expression. Mol Cancer. 2023 May 29;22(1):88. doi: 10.1186/s12943-023-01792-0.
1224 [Reversal of multidrug resistance of gastric cancer cells by down-regulation of CIAPIN1 with CIAPIN1 siRNA]. Mol Biol (Mosk). 2008 Jan-Feb;42(1):102-9.
1225 H(1)R mediates local anesthetic-induced vascular permeability in angioedema. Toxicol Appl Pharmacol. 2020 Apr 1;392:114921. doi: 10.1016/j.taap.2020.114921. Epub 2020 Feb 12.
1226 Rifampin Regulation of Drug Transporters Gene Expression and the Association of MicroRNAs in Human Hepatocytes. Front Pharmacol. 2016 Apr 26;7:111.
1227 Estrogen utilization of IGF-1-R and EGF-R to signal in breast cancer cells. J Steroid Biochem Mol Biol. 2010 Feb 28;118(4-5):219-30. doi: 10.1016/j.jsbmb.2009.09.018. Epub 2009 Oct 6.
1228 Implication of the insulin-like growth factor-IR pathway in the resistance of non-small cell lung cancer cells to treatment with gefitinib. Clin Cancer Res. 2007 May 1;13(9):2795-803. doi: 10.1158/1078-0432.CCR-06-2077.
1229 Simvastatin inhibits the proliferation of human prostate cancer PC-3 cells via down-regulation of the insulin-like growth factor 1 receptor. Biochem Biophys Res Commun. 2008 Jul 25;372(2):356-61. doi: 10.1016/j.bbrc.2008.05.043. Epub 2008 May 19.
1230 Combined tamoxifen and gefitinib in non-small cell lung cancer shows antiproliferative effects. Biomed Pharmacother. 2010 Feb;64(2):88-92. doi: 10.1016/j.biopha.2009.06.010. Epub 2009 Oct 23.
1231 Comparison of an array of in vitro assays for the assessment of the estrogenic potential of natural and synthetic estrogens, phytoestrogens and xenoestrogens. Toxicology. 2001 Sep 14;166(1-2):79-89. doi: 10.1016/s0300-483x(01)00437-1.
1232 Estrogenic effects of natural and synthetic compounds including tibolone assessed in Saccharomyces cerevisiae expressing the human estrogen alpha and beta receptors. FASEB J. 2006 Jul;20(9):1552-4. doi: 10.1096/fj.05-5413fje. Epub 2006 May 23.
1233 Comparison of relative binding affinities to fish and mammalian estrogen receptors: the regulatory implications. Toxicol Lett. 2010 Feb 15;192(3):298-315. doi: 10.1016/j.toxlet.2009.11.004. Epub 2009 Nov 12.
1234 Screening for estrogen and androgen receptor activities in 200 pesticides by in vitro reporter gene assays using Chinese hamster ovary cells. Environ Health Perspect. 2004 Apr;112(5):524-31. doi: 10.1289/ehp.6649.
1235 Valproic acid and its derivatives enhanced estrogenic activity but not androgenic activity in a structure dependent manner. Reprod Toxicol. 2013 Dec;42:49-57. doi: 10.1016/j.reprotox.2013.07.019. Epub 2013 Jul 26.
1236 Relationship between estrogen receptor-binding and estrogenic activities of environmental estrogens and suppression by flavonoids. Biosci Biotechnol Biochem. 2002 Jul;66(7):1479-87. doi: 10.1271/bbb.66.1479.
1237 Arylpiperazines for management of benign prostatic hyperplasia: design, synthesis, quantitative structure-activity relationships, and pharmacokinetic studies. J Med Chem. 2011 Jan 13;54(1):302-11. doi: 10.1021/jm101163m. Epub 2010 Dec 3.
1238 Identification of flucloxacillin-modified hepatocellular proteins: implications in flucloxacillin-induced liver injury. Toxicol Sci. 2023 Mar 20;192(1):106-116. doi: 10.1093/toxsci/kfad015.
1239 Decitabine up-regulates S100A2 expression and synergizes with IFN-gamma to kill uveal melanoma cells. Clin Cancer Res. 2007 Sep 1;13(17):5219-25. doi: 10.1158/1078-0432.CCR-07-0816.
1240 Role of microRNAs in senescence and its contribution to peripheral neuropathy in the arsenic exposed population of West Bengal, India. Environ Pollut. 2018 Feb;233:596-603. doi: 10.1016/j.envpol.2017.09.063. Epub 2017 Nov 5.
1241 Geraniol suppresses prostate cancer growth through down-regulation of E2F8. Cancer Med. 2016 Oct;5(10):2899-2908.
1242 Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells. Nat Commun. 2018 Aug 9;9(1):3069. doi: 10.1038/s41467-018-05402-2.
1243 Cytotoxic T cell targeting of TRP-2 sensitizes human malignant glioma to chemotherapy. Oncogene. 2005 Aug 4;24(33):5226-34. doi: 10.1038/sj.onc.1208519.
1244 Post-transcriptional regulation of melanin biosynthetic enzymes by cAMP and resveratrol in human melanocytes. J Invest Dermatol. 2007 Sep;127(9):2216-27. doi: 10.1038/sj.jid.5700840. Epub 2007 Apr 26.
1245 Changes in gene expressions elicited by physiological concentrations of genistein on human endometrial cancer cells. Mol Carcinog. 2006 Oct;45(10):752-63.
1246 JWA, a novel signaling molecule, involved in all-trans retinoic acid induced differentiation of HL-60 cells. J Biomed Sci. 2006 May;13(3):357-71. doi: 10.1007/s11373-005-9068-0. Epub 2006 Feb 9.
1247 [Arsenic trioxide induced p15INK4B gene expression in myelodysplastic syndrome cell line MUTZ-1]. Zhonghua Xue Ye Xue Za Zhi. 2002 Dec;23(12):638-41.
1248 Effects of histamine H(2)-receptor antagonists on human plasma levels of calcitonin gene-related peptide, substance P and vasoactive intestinal peptide. J Pharm Pharmacol. 2002 Nov;54(11):1559-63. doi: 10.1211/002235702117.
1249 Transient receptor potential vanilloid 1-mediated expression and secretion of endothelial cell-derived calcitonin gene-related peptide. Regul Pept. 2008 Oct 9;150(1-3):66-72. doi: 10.1016/j.regpep.2008.05.007. Epub 2008 Jun 3.
1250 Intriguing response to azacitidine in a patient with juvenile myelomonocytic leukemia and monosomy 7. Blood. 2009 Mar 19;113(12):2867-8. doi: 10.1182/blood-2008-12-195693.
1251 Methotrexate-mediated activation of an AMPK-CREB-dependent pathway: a novel mechanism for vascular protection in chronic systemic inflammation. Ann Rheum Dis. 2016 Feb;75(2):439-48. doi: 10.1136/annrheumdis-2014-206305. Epub 2015 Jan 9.
1252 The effects of desmethylimipramine on cyclic AMP-stimulated gene transcription in a model cell system. Biochem Pharmacol. 2005 Sep 1;70(5):762-9. doi: 10.1016/j.bcp.2005.06.012.
1253 The induction of cytochrome P450 2E1 by ethanol leads to the loss of synaptic proteins via PPARalpha down-regulation. Toxicology. 2017 Jun 15;385:18-27.