Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHTEAO)

Drug Name
Carvedilol Drug Info
Synonyms
Artist; Carvedilolum; Coreg; Coropres; Coropress; Dibloc; Dilatrend; Eucardic; Kredex; Querto; Atlana Pharma brand of carvedilol; Carvedilolum [Latin]; Coreg CR; GlaxoSmithKline brand of carvedilol; Lakeside brand of carvedilol; Roche brand of carvedilol; BM 14190; DQ 2466; SKF 105517; Artist (TN); BM-14190; Carloc (TN); Coreg (TN); DQ-2466; Dilatrend (TN); EG-P042; Eucardic (TN); BM-14-190; BM-14.190; Carvedilol, 14C-labeled; SK&F-105517; Carvedilol (JAN/USAN/INN); Carvedilol [USAN:INN:BAN:JAN]; Carvedilol, (R)-isomer; Carvedilol, (S)-isomer; Carvedilol, (+-)-isomer; (+-)-1-(Carbazol-4-yloxy)-3-((2-(o-methoxyphenoxy)ethyl)amino)-2-propanol; (+-)-1-Carbazol-4-yloxy)-3-((2-(o-methoxyphenoxy)ethyl)amino)-2-propanol; (+/-)-1-(Carbazol-4-yloxy)-3-[[2-(o-methoxyphenoxy)ethyl]amino]-2-propanol; 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol; 1-(9H-carbazol-4-yloxy)-3-[(2-{[2-(methyloxy)phenyl]oxy}ethyl)amino]propan-2-ol; 1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol; 1-(9H-carbazol-4-yloxy)-3-{[2-(2-methoxyphenoxy)ethyl]amino}propan-2-ol
Indication
Disease Entry ICD 11 Status REF
Chronic heart failure BD1Z Approved [1]
Congestive heart failure BD10 Approved [2]
Pulmonary hypertension BB01 Approved [1]
Coronavirus Disease 2019 (COVID-19) 1D6Y Investigative [3]
Therapeutic Class
Vasodilator Agents
Cross-matching ID
PubChem CID
2585
ChEBI ID
CHEBI:3441
CAS Number
CAS 72956-09-3
TTD Drug ID
DMHTEAO
VARIDT Drug ID
DR00689
INTEDE Drug ID
DR0282
ACDINA Drug ID
D00103

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Discontinued Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Adrenergic receptor Alpha-1 (ADRA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Labetalol DMK8U72 Hypertension BA00-BA04 Approved [4]
Prazosin DMCD9YG Benign prostatic hyperplasia GA90 Approved [22]
Ergotamine DMKR3C5 Cluster headache 8A81.0 Approved [23]
Midodrine DME2PY5 Orthostatic hypotension BA21 Approved [24]
Urapidil DMD59GI Hypertension BA00-BA04 Approved [25]
Phenylpropanolamine DMTFK3O Allergic rhinitis CA08.0 Withdrawn from market [26]
Metazosin DMAZ28C Cardiac disease BA00-BE2Z Discontinued in Phase 3 [27]
DC-015 DMCDMWJ N. A. N. A. Terminated [28]
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Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [29]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [30]
Methotrexate DM2TEOL Anterior urethra cancer Approved [31]
Folic Acid DMEMBJC Colorectal carcinoma Approved [32]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [31]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [31]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [33]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [31]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [34]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [35]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [36]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [37]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [38]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [39]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [40]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [41]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [42]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [43]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [37]
Verapamil DMA7PEW Angina pectoris BA40 Approved [9]
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Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [44]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [45]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [46]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [47]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [48]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [49]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [42]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [50]
Verapamil DMA7PEW Angina pectoris BA40 Approved [51]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [52]
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Drug(s) Metabolized By UDP-glucuronosyltransferase 1A1 (UGT1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [53]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [54]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [55]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [56]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [57]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [59]
Metronidazole DMTIVEN Abscess Approved [11]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [60]
Ethanol DMDRQZU Chronic pain MG30 Approved [61]
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Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [62]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [63]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [64]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [40]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [9]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [65]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [66]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [67]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [68]
Propranolol DM79NTF Angina pectoris BA40 Approved [69]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [95]
Paliperidone DM7NPJS Psychotic disorder 6A20-6A25 Approved [96]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [97]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [98]
Oxatomide DM1F42Z Hay fever CA08.00 Approved [99]
Cinacalcet DMCX0K3 Hyperparathyroidism 5A51 Approved [100]
Capsaicin DMGMF6V Back pain ME84.Z Approved [101]
Pentamidine DMHZJCG African trypanosomiasis 1F51 Approved [102]
Quinidine DMLPICK N. A. N. A. Approved [103]
Buprenorphine DMPRI8G Opioid dependence 6C43.2Z Approved [104]
⏷ Show the Full List of 20 Drug(s)
Drug(s) Metabolized By Cytochrome P450 2E1 (CYP2E1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Folic Acid DMEMBJC Colorectal carcinoma Approved [70]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [71]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [72]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [73]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [74]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [50]
Verapamil DMA7PEW Angina pectoris BA40 Approved [75]
Estrone DM5T6US Acne vulgaris ED80 Approved [76]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [77]
Ethanol DMDRQZU Chronic pain MG30 Approved [78]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [79]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [80]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [81]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [75]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [82]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [75]
Verapamil DMA7PEW Angina pectoris BA40 Approved [83]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [84]
Estrone DM5T6US Acne vulgaris ED80 Approved [85]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [86]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By UDP-glucuronosyltransferase 2B7 (UGT2B7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [87]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [88]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [9]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [89]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [90]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [9]
PITAVASTATIN CALCIUM DM1UJO0 Dyslipidemia 5C80-5C81 Approved [91]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [92]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [93]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [94]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [105]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [106]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [107]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [108]
Cepharanthine DM9Y5JB N. A. N. A. Approved [109]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [110]
Clozapine DMFC71L Schizophrenia 6A20 Approved [111]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [112]
Trifluoperazine DMKBYWI Anxiety Approved [113]
Olanzapine DMPFN6Y Bipolar depression Approved [111]
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Drug(s) Affected By Beta-1 adrenergic receptor (ADRB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dobutamine DMD1B8Z Heart failure BD10-BD13 Approved [114]
Methotrexate DM2TEOL Anterior urethra cancer Approved [115]
Vortioxetine DM6F1PU Major depressive disorder 6A70.3 Approved [116]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [117]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [118]
Labetalol DMK8U72 Hypertension BA00-BA04 Approved [119]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [120]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [121]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [122]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [123]
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Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [124]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [125]
Paclitaxel DMLB81S Breast carcinoma Approved [126]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [127]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [128]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [129]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [130]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [131]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [132]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [133]
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Drug(s) Affected By Epidermal growth factor receptor (EGFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [134]
Gefitinib DM15F0X Colon adenocarcinoma Approved [135]
Erlotinib DMCMBHA Adrenal gland neoplasm Approved [136]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [137]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [138]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [139]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [140]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [141]
Selenium DM25CGV N. A. N. A. Approved [142]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [143]
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Drug(s) Affected By Potassium channel subfamily K member 3 (KCNK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [144]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [145]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [117]
Folic Acid DMEMBJC Colorectal carcinoma Approved [146]
Paclitaxel DMLB81S Breast carcinoma Approved [147]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [148]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [149]
Riociguat DMXBLMP Chronic thromboembolic pulmonary hypertension Approved [150]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [151]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [152]
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Drug(s) Affected By Renin (REN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [153]
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [154]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [155]
Reboxetine DM26PRD Depression 6A70-6A7Z Approved [156]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [157]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [158]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [159]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [160]
Epinephrine DM3KJBC Acute asthma CA23 Approved [161]
Chlorthalidone DM4DMBT Edema MG29 Approved [162]
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Drug(s) Affected By Angiotensinogen (AGT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [163]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [164]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [165]
Reboxetine DM26PRD Depression 6A70-6A7Z Approved [156]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [166]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [167]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [159]
Quercetin DM3NC4M Obesity 5B81 Approved [168]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [169]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [170]
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Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [171]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [129]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [172]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [173]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [174]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [175]
Prednisone DM2HG4X Acute asthma CA23 Approved [176]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [177]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [178]
Methotrexate DM2TEOL Anterior urethra cancer Approved [179]
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Drug(s) Affected By Natriuretic peptides A (NPPA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [180]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [181]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [182]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Cilazapril DM4V6JA Congestive heart failure BD10 Approved [184]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [169]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [185]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [186]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [117]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [187]
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Drug(s) Affected By Vasopressin-neurophysin 2-copeptin (AVP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [188]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [189]
Oxprenolol DM51OQW Anxiety Approved [190]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [191]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [117]
Luvox DMJKROX Anxiety disorder 6B00-6B0Z Approved [192]
Sodium chloride DMM3950 Skin burns ME65.0 Approved [193]
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [189]
Chlorpropamide DMPHZQE Non-insulin dependent diabetes 5A11 Approved [194]
Indomethacin DMSC4A7 Bursitis Approved [195]
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Drug(s) Affected By Insulin (INS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [196]
Methotrexate DM2TEOL Anterior urethra cancer Approved [179]
Epinephrine DM3KJBC Acute asthma CA23 Approved [197]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [198]
Fructose DM43AN2 Vomiting MD90 Approved [199]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [200]
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [201]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [202]
Propranolol DM79NTF Angina pectoris BA40 Approved [203]
Testosterone DM7HUNW Hot flushes GA30 Approved [204]
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Drug(s) Affected By C-reactive protein (CRP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lidocaine DML4ZOT Anaesthesia 9A78.6 Approved [129]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [205]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [206]
Quercetin DM3NC4M Obesity 5B81 Approved [207]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [208]
Acalabrutinib DM7GCVW leukaemia 2A60-2B33 Approved [209]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [210]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [211]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [212]
Testosterone DM7HUNW Hot flushes GA30 Approved [213]
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Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [214]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [19]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [215]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [216]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [217]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [218]
Ethacrynic acid DM60QMR Edema MG29 Approved [219]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [220]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [221]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [222]
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Drug(s) Affected By Endothelin-1 (EDN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [223]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [224]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [225]
Methotrexate DM2TEOL Anterior urethra cancer Approved [226]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [227]
Quercetin DM3NC4M Obesity 5B81 Approved [228]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [229]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [230]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [231]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [232]
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Drug(s) Affected By Beta-2 adrenergic receptor (ADRB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salmeterol DMIEU69 Allergic asthma CA23.0 Approved [233]
Bambuterol DMKLSHF Asthma CA23 Approved [234]
Terbutaline DMD4381 Asthma CA23 Approved [235]
Salbutamol DMN9CWF Acute asthma CA23 Approved [236]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [237]
Methotrexate DM2TEOL Anterior urethra cancer Approved [115]
Epinephrine DM3KJBC Acute asthma CA23 Approved [238]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [239]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [240]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [241]
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Drug(s) Affected By Heme oxygenase 1 (HMOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [242]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [243]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [244]
Verapamil DMA7PEW Angina pectoris BA40 Approved [245]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [246]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [247]
Selenium DM25CGV N. A. N. A. Approved [248]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [249]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [250]
Methotrexate DM2TEOL Anterior urethra cancer Approved [226]
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Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [251]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [252]
Gefitinib DM15F0X Colon adenocarcinoma Approved [253]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [254]
Selenium DM25CGV N. A. N. A. Approved [142]
Pentosan Polysulfate DM2HRKE Interstitial cystitis GC00.3 Approved [255]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [256]
Methotrexate DM2TEOL Anterior urethra cancer Approved [257]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [258]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [259]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Natriuretic peptides B (NPPB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [181]
Methotrexate DM2TEOL Anterior urethra cancer Approved [115]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [260]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [261]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [231]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [262]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [224]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [117]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [263]
Ethanol DMDRQZU Chronic pain MG30 Approved [264]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Gap junction alpha-1 protein (GJA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [265]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [266]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [239]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [267]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [117]
Folic Acid DMEMBJC Colorectal carcinoma Approved [268]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [269]
Letrozole DMH07Y3 Estrogen-receptor positive breast cancer Approved [265]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [270]
Griseofulvin DMK54YG Onychomycosis EE12.1 Approved [271]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-10 (IL10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [272]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [273]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [274]
Methotrexate DM2TEOL Anterior urethra cancer Approved [275]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [276]
Quercetin DM3NC4M Obesity 5B81 Approved [277]
Bisoprolol DM3UZ95 Hypertension BA00-BA04 Approved [278]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [279]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [280]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [281]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [128]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [125]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [282]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [131]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [132]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [133]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [283]
Gefitinib DM15F0X Colon adenocarcinoma Approved [284]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [285]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [286]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Potassium voltage-gated channel subfamily H member 2 (KCNH2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Metoclopramide DMFA5MY Nausea MD90 Approved [287]
Quinidine DMLPICK N. A. N. A. Approved [288]
Verapamil DMA7PEW Angina pectoris BA40 Approved [289]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [290]
Clarithromycin DM4M1SG Acute maxillary sinusitis Approved [290]
Disopyramide DM5SYZP Long QT syndrome BC65.0 Approved [291]
Propranolol DM79NTF Angina pectoris BA40 Approved [292]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [293]
Dofetilide DMPN1TW Sinus rhythm disorder BC9Y Approved [294]
Flecainide DMSQDLE Tachyarrhythmias BC71 Approved [290]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Adiponectin (ADIPOQ)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [295]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [295]
Ramipril DM2R68E Acute heart failure BD10-BD13 Approved [296]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [297]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [295]
Cilazapril DM4V6JA Congestive heart failure BD10 Approved [298]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [299]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [295]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [300]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [301]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [19]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [302]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [303]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [304]
Estrone DM5T6US Acne vulgaris ED80 Approved [305]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [306]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [307]
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [308]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [309]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [244]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ryanodine receptor 2 (RYR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [117]
Isoproterenol DMK7MEY Atrioventricular block Approved [310]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [311]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [312]
Atenolol DMNKG1Z Angina pectoris BA40 Approved [313]
Metoprolol DMOJ0V6 Acute coronary syndrome BA41 Approved [313]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [311]
Arsenic DMTL2Y1 N. A. N. A. Approved [314]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [311]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [315]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Vascular endothelial growth factor receptor 2 (KDR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [316]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [261]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [317]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [318]
Haloperidol DM96SE0 Delirium Approved [319]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [145]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [320]
Clozapine DMFC71L Schizophrenia 6A20 Approved [319]
Menthol DMG2KW7 Back pain ME84.Z Approved [321]
Orlistat DMRJSP8 Obesity 5B81 Approved [322]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proto-oncogene tyrosine-protein kinase Src (SRC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bosutinib DMTI8YE Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [323]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [324]
Methotrexate DM2TEOL Anterior urethra cancer Approved [179]
Quercetin DM3NC4M Obesity 5B81 Approved [325]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [326]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [327]
Plicamycin DM7C8YV Hypercalcaemia 5B91.0 Approved [328]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [329]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [329]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [117]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Adrenergic receptor Alpha-1 (ADRA1) TTG28O6 NOUNIPROTAC Antagonist [4]
HUAMN alpha-1 adrenergic receptor (ADRA1) TTDBOI7 ADA1A_HUMAN; ADA1B_HUMAN; ADA1D_HUMAN Inhibitor [5]
HUMAN beta adrenergic receptor (BAR) TTJB8UY ADRB1_HUMAN; ADRB2_HUMAN; ADRB3_HUMAN Antagonist [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [6]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [7]
Cytochrome P450 2E1 (CYP2E1) DEVDYN7 CP2E1_HUMAN Substrate [8]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Substrate [9]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Substrate [10]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Substrate [11]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Substrate [12]
UDP-glucuronosyltransferase 2B7 (UGT2B7) DEB3CV1 UD2B7_HUMAN Substrate [11]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Adiponectin (ADIPOQ) OTNX23LE ADIPO_HUMAN Gene/Protein Processing [13]
Angiotensinogen (AGT) OTBZLYR3 ANGT_HUMAN Gene/Protein Processing [14]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Regulation of Drug Effects [15]
Beta-1 adrenergic receptor (ADRB1) OTQBWN4U ADRB1_HUMAN Gene/Protein Processing [16]
Beta-2 adrenergic receptor (ADRB2) OTSDOX4Q ADRB2_HUMAN Post-Translational Modifications [17]
C-reactive protein (CRP) OT0RFT8F CRP_HUMAN Gene/Protein Processing [18]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Gene/Protein Processing [19]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Gene/Protein Processing [19]
Cytochrome P450 2D6 (CYP2D6) OTZJC802 CP2D6_HUMAN Biotransformations [20]
Endothelin-1 (EDN1) OTZCACEG EDN1_HUMAN Gene/Protein Processing [21]

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