Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM1RBYG)

• Drug Name: Nitric Oxide Drug Info
• Synonyms: Nitric oxide; nitric oxide; nitrogen monoxide; Mononitrogen monoxide; 10102-43-9; nitrogen monooxide; nitrogen protoxide; nitrosyl; Nitrosyl radical; EDRF; CHEBI:16480; endothelium-derived relaxing factor; monoxyde d'azote; oxoazanyl; oxyde azotique; oxido nitrico; Stickstoffmonoxid; Nitric oxide trimer; monoxido de nitrogeno; Stickstoff(II)-oxid; Nitric oxide (JAN); INOmax (TN); oxido de nitrogeno(II); Nitrosoradical; [NO]; oxidonitrogen(); Nitrogen(II) oxide; OHM 11771; AC1L3QHF; Nitric oxide, 985%; DTXSID1020938; CHEMBL1200689; CTK0H7679; ()NO; HNO; INOmax; Nitrosyl; Nitroxyl; Oxoazanyl; Stickmonoxyd; Endogenous Nitrate Vasodilator; Monoxido de nitrogeno; Nitrogen monooxide; Nitrogen monoxide; Nitrosyl hydride; Nitroxide radical; Oxido nitrico; Oxyde azotique; Oxyde nitrique [French]; Stickmonoxyd [German]; Bioxyde d'azote; Bioxyde d'azote [French]; Endothelium-Derived Nitric Oxide; Monoxide, Mononitrogen; Monoxide, Nitrogen; Monoxyde d'azote; NITRIC-OXIDE; NO(); Nitrate Vasodilator, Endogenous; Nitric Oxide, Endothelium Derived; Nitric oxide 10% by volume or more; Nitric oxide, compressed [UN1660] [Poison gas]; Nitrogen oxide (NO); Oxide, Nitric; Oxido de nitrogeno(II); Oxidonitrogen(); Vasodilator, Endogenous Nitrate; Nitric Oxide, Endothelium-Derived; Nitrosyl hydride ((NO)H); Endothelium-derived relaxing factor (EDRF)

Indication

Disease Entry	ICD 11	Status	REF
Hypertension	BA00-BA04	Approved	[1]
Methicillin-resistant staphylococci infection	1A00-1A09	Approved	[2]
Pneumonia	CA40	Approved	[2]
Pulmonary hypertension	BB01	Approved	[2]
Respiratory failure	CB41	Approved	[3]
Solid tumour/cancer	2A00-2F9Z	Phase 3	[3]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 2	[4]
Tinea pedis	1F28.2	Discontinued in Phase 2	[5]

• Therapeutic Class: Bronchodilator Agents
• Cross-matching ID:
  PubChem CID: 145068
  ChEBI ID: CHEBI:16480
  CAS Number: CAS 10102-43-9
  TTD Drug ID: DM1RBYG
  VARIDT Drug ID: DR01184

Molecule-Related Drug Atlas

Drug(s) Targeting Soluble guanylate cyclase (GCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitroglycerin	DMQ2491	Angina pectoris	BA40	Approved	[14]
Sodium nitroprusside	DMGA9X0	Hypertension	BA00-BA04	Approved	[15]
IW-1973	DMK2T7J	Heart failure	BD10-BD13	Phase 2	[16]
CTI-1601	DMM4JMB	Friedreich's ataxia	8A03.10	Phase 2	[17]
Runcaciguat	DMCFTTN	Chronic kidney disease	GB61	Phase 2	[18]
MK-5475	DMIIZ4R	Pulmonary arterial hypertension	BB01.0	Phase 2	[19]
CY6463	DM84AVQ	Alzheimer disease	8A20	Phase 2	[20]
CY6463	DM84AVQ	Alzheimer disease	8A20	Phase 2	[21]
(5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol	DM15P2G	Discovery agent	N.A.	Investigative	[14]

Drug(s) Targeting Guanylate cyclase (GC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isosorbide Dinitrate	DMBI4JG	Anal fissure	DB50.0	Approved	[6]
Methylene blue	DMJAPE7	Acquired methemoglobinemia	3A93	Approved	[22]
Isosorbide Mononitrate	DMYLMU0	Angina pectoris	BA40	Approved	[6]
Erythrityl Tetranitrate	DMFGQ2S	Angina pectoris	BA40	Approved	[6]
Pirsidomine	DMHI6GE	Angina pectoris	BA40	Phase 2	[23]
IW-1701	DM457XO	Sickle-cell disorder	3A51	Phase 2	[24]

Drug(s) Transported By Alanine/serine/cysteine/threonine transporter 2 (SLC1A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aciclovir	DMYLOVR	Genital herpes	1A94	Approved	[25]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[25]
Levacecarnine hci	DMJBOCR	Cognitive impairment	6D71	Approved	[26]
Glycine	DMIOZ29	Allergic rhinitis	CA08.0	Approved	[27]
L-glutamine	DM69G8X	Short bowel syndrome	KB89.1	Approved	[28]
Valaciclovir	DMHKS94	Genital herpes	1A94	Approved	[29]
Valganciclovir	DMS2IUH	Virus infection	1A24-1D9Z	Approved	[30]
D-Serine	DM3YH4I	N. A.	N. A.	Phase 4	[31]
L-threonine	DMFHTBX	Discovery agent	N.A.	Investigative	[31]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[32]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[34]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[35]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[39]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[41]

Drug(s) Affected By Protein phosphatase 1D (PPM1D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[42]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[44]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[45]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[46]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[47]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[50]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[51]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[52]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[53]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[54]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[55]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[56]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]

Drug(s) Affected By Lysine-specific histone demethylase 1A (KDM1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[60]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[64]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[66]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[67]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[68]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[69]

Drug(s) Affected By Lysine-specific demethylase 4A (KDM4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[72]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[73]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[75]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[76]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[67]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[77]

Drug(s) Affected By Lysine-specific demethylase 4B (KDM4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Bortezomib	DMNO38U	Leukemia		Approved	[80]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[81]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[82]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[83]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[75]

Drug(s) Affected By Apoptosis-inducing factor 1, mitochondrial (AIFM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[84]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[85]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[86]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[87]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[88]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[89]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[90]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[93]
Haloperidol	DM96SE0	Delirium		Approved	[94]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[32]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[95]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[97]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[98]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[99]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[101]

Drug(s) Affected By Hypoxanthine-guanine phosphoribosyltransferase (HPRT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[102]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[103]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[104]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[101]
Fructose	DM43AN2	Vomiting	MD90	Approved	[105]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[106]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[108]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[109]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[110]
Fructose	DM43AN2	Vomiting	MD90	Approved	[94]
Ketoprofen	DMRKXPT	Bursitis		Approved	[94]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[111]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[112]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[113]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[114]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[115]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[116]

Drug(s) Affected By Interferon gamma (IFNG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[117]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[118]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[119]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[104]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[120]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[121]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[123]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[124]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[125]

Drug(s) Affected By C-X-C motif chemokine 10 (CXCL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[128]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[125]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[130]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[131]

Drug(s) Affected By Thymidine kinase, cytosolic (TK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[132]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[133]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[134]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[135]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[137]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[138]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[108]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[139]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[104]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[140]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[141]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[142]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[143]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[144]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[145]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[146]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[147]

Drug(s) Affected By Integrin beta-3 (ITGB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[148]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[149]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[151]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[152]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[153]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[154]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[155]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[156]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]

Drug(s) Affected By Interleukin-5 (IL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolnaftate	DM28MU7	Dermatophytosis	1F28.2	Approved	[158]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[159]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[160]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[161]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[162]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[163]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[165]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[167]

Drug(s) Affected By Annexin A5 (ANXA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[168]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[106]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[169]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[64]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[170]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[170]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[171]

Drug(s) Affected By Macrophage colony-stimulating factor 1 (CSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[95]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[168]
Selenium	DM25CGV	N. A.	N. A.	Approved	[172]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[104]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[173]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[174]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[108]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[70]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[175]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[176]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[177]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[178]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[179]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[178]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[180]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[181]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[182]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[183]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[184]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[185]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[186]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[187]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[188]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[189]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[190]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[190]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[191]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[192]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[193]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[194]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[195]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[94]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[175]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[196]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[197]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[112]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[198]

Drug(s) Affected By Uteroglobin (SCGB1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[199]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[200]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[201]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[202]
Deoxythymidine	DMR90HY	Discovery agent	N.A.	Investigative	[203]

Drug(s) Affected By C-C motif chemokine 5 (CCL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[95]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[204]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[104]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[205]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[135]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[128]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[207]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[208]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[209]

Drug(s) Affected By Metalloproteinase inhibitor 2 (TIMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[210]
Selenium	DM25CGV	N. A.	N. A.	Approved	[211]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[212]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[213]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[214]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[215]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Tetracaine	DM9J6C2	Spinal anesthesia	MB40.3	Approved	[216]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[150]

Drug(s) Affected By Beta-galactosidase (GLB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[217]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[218]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[219]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[220]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[221]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[64]
Bendamustine hydrochloride	DMFH15Z	leukaemia	2A60-2B33	Approved	[222]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[223]

Drug(s) Affected By Interleukin-10 (IL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[224]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[159]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[225]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[226]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[227]
Bisoprolol	DM3UZ95	Hypertension	BA00-BA04	Approved	[228]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[229]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[125]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[230]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[32]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[231]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[232]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[233]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[234]
Fructose	DM43AN2	Vomiting	MD90	Approved	[105]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[235]
Vismodegib	DM5IXKQ	Basal cell carcinoma	2C32	Approved	[236]

Drug(s) Affected By Dual specificity protein phosphatase 1 (DUSP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[175]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[237]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[238]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[225]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[239]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[240]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[241]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[108]

Drug(s) Affected By Interleukin-12 subunit beta (IL12B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[122]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[125]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[174]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[242]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[243]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[244]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[245]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[246]
Bryostatin-1	DM1JOXY	Alzheimer disease	8A20	Phase 2	[247]
RGI-2001	DM4AC2F	Graft-versus-host disease	4B24	Phase 2	[248]

Drug(s) Affected By Nitric oxide synthase, inducible (NOS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Indomethacin	DMSC4A7	Bursitis		Approved	[98]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[249]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[219]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[250]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[251]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[101]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[252]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[253]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[254]

Drug(s) Affected By T-lymphocyte activation antigen CD86 (CD86)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
Kanamycin	DM2DMPO	Bacteremia	1A73	Approved	[256]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[104]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[257]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[256]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[258]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[256]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[257]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[259]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[260]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[261]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[142]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[262]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[263]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[264]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[265]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[266]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[267]

Drug(s) Affected By Caspase-7 (CASP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[268]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[237]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[269]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[270]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[270]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[219]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[271]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[272]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[273]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[274]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[275]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[276]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[175]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[197]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[277]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[249]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[278]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[279]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[280]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[181]

Drug(s) Affected By BH3-interacting domain death agonist (BID)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[281]
Selenium	DM25CGV	N. A.	N. A.	Approved	[282]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[283]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[284]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[285]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[286]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]

Drug(s) Affected By Beta-2-microglobulin (B2M)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[287]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[85]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[288]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[289]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[290]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[291]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[64]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[292]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[293]

Drug(s) Affected By Cytochrome c (CYCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[281]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[294]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[176]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[277]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[295]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[104]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[296]
Pefloxacin	DM49IGF	Gonococcal urethritis	1A70.0Y	Approved	[297]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[298]

Drug(s) Affected By Caveolin-1 (CAV1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[198]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[299]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[300]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[301]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[302]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[106]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[303]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[304]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[145]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[305]
Selenium	DM25CGV	N. A.	N. A.	Approved	[172]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[306]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[219]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[307]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[308]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[283]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[309]

Drug(s) Affected By PR domain zinc finger protein 2 (PRDM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[172]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[310]
Bortezomib	DMNO38U	Leukemia		Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[311]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[312]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[313]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 3 (BIRC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[314]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[267]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[84]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[219]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[235]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[315]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[316]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[317]

Drug(s) Affected By Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[318]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[319]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[320]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[183]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[321]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[252]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[322]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[323]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[324]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[325]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[326]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[327]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[281]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[328]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[329]
Selenium	DM25CGV	N. A.	N. A.	Approved	[172]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[279]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[104]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[271]

Drug(s) Affected By Quinone oxidoreductase PIG3 (TP53I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[219]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[330]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[331]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[332]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[47]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[333]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[48]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]

Drug(s) Affected By Lysine-specific demethylase 4D (KDM4D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[168]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[334]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[335]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[336]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[337]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[338]

Drug(s) Affected By Lysine-specific demethylase 7A (KDM7A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[175]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[339]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[340]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[341]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[313]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]

Drug(s) Affected By Lysine-specific demethylase 3B (KDM3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[64]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[210]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[313]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[68]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[69]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[342]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[343]

Drug(s) Affected By Protein NDRG1 (NDRG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[116]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[344]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[345]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[135]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[346]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[63]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[341]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[347]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[348]

Drug(s) Affected By Caspase-10 (CASP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[84]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[85]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[349]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[134]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[350]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[47]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]

Drug(s) Affected By Histone-lysine N-methyltransferase EHMT2 (EHMT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[351]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[54]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[352]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[221]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[64]
Bortezomib	DMNO38U	Leukemia		Approved	[80]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]

Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[210]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[54]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[320]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[353]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[354]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[252]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[324]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[355]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[356]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[46]

Drug(s) Affected By Histone-lysine N-methyltransferase SETDB2 (SETDB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[357]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[341]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[347]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[358]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[358]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[67]

Drug(s) Affected By Lysine-specific demethylase 4C (KDM4C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[359]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[201]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[75]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[334]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[360]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[335]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[342]

Drug(s) Affected By Histone-lysine N-methyltransferase SUV39H2 (SUV39H2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[210]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[108]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[108]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[357]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[154]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[361]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[362]

Drug(s) Affected By Diablo IAP-binding mitochondrial protein (DIABLO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[363]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[85]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[183]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[233]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[364]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[285]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[241]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[64]
Bendamustine hydrochloride	DMFH15Z	leukaemia	2A60-2B33	Approved	[274]

Drug(s) Affected By Histone lysine demethylase PHF8 (PHF8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[70]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[365]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[366]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[367]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[76]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[68]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[69]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[342]

Drug(s) Affected By Lysine-specific demethylase 3A (KDM3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[319]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[323]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[368]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[70]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[48]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[281]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[189]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[369]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[190]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[190]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[370]
Selenium	DM25CGV	N. A.	N. A.	Approved	[371]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[372]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[373]

Drug(s) Affected By Carboxypeptidase D (CPD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[88]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[374]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[221]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[375]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[64]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[80]

Drug(s) Affected By Kininogen-1 (KNG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Mepyramine	DMB4SFH	Allergic rhinitis	CA08.0	Approved	[376]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[376]
Perindopril	DMOPZDT	Hypertension	BA00-BA04	Approved	[377]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[378]
Indomethacin	DMSC4A7	Bursitis		Approved	[376]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[210]

Drug(s) Affected By Nitric oxide synthase 1 (NOS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[32]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[379]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[380]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[381]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[380]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[382]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[171]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[383]
Bortezomib	DMNO38U	Leukemia		Approved	[384]
Interferon gamma-1b	DMWUMRL	Chronic granulomatous disease	4A00.0Y	Approved	[94]

Drug(s) Affected By Angiotensinogen (AGT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[385]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[386]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[210]
Reboxetine	DM26PRD	Depression	6A70-6A7Z	Approved	[387]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[388]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[389]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[390]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[391]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[392]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[393]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[318]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[187]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[394]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[189]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[238]
Selenium	DM25CGV	N. A.	N. A.	Approved	[395]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[396]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[397]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[219]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[238]
Selenium	DM25CGV	N. A.	N. A.	Approved	[371]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[398]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[399]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[99]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[400]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[380]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[134]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[401]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]

Drug(s) Affected By Nitric oxide synthase 3 (NOS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[402]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[403]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[94]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[404]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[78]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[405]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[406]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[407]
Fructose	DM43AN2	Vomiting	MD90	Approved	[408]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[409]

Drug(s) Affected By Brain-derived neurotrophic factor (BDNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[410]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[299]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[411]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[106]
Bupivacaine	DM4PRFC	Anaesthesia	9A78.6	Approved	[412]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[413]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[241]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]

Drug(s) Affected By Glutathione S-transferase P (GSTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[414]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[154]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[415]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[415]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[416]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[417]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[418]
Selenium	DM25CGV	N. A.	N. A.	Approved	[172]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[419]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[420]

Drug(s) Affected By Prothrombin (F2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[421]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[104]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[422]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[423]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[239]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[424]
Phytonadione	DM8HDOL	Bleeding disorder	GA20-GA21	Approved	[425]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[426]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[427]

Drug(s) Affected By Myeloperoxidase (MPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[365]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[94]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[94]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[428]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[429]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[430]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[431]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[432]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[433]

Drug(s) Affected By Guanylate cyclase soluble subunit alpha-1 (GUCY1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[434]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[435]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[436]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[72]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[437]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[367]

Drug(s) Affected By HLA class II histocompatibility antigen, DRB1 beta chain (HLA-DRB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[438]
Clindamycin	DM15HL8	Acne vulgaris	ED80	Approved	[438]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[438]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Cefepime	DMHVWIK	Bacterial infection	1A00-1C4Z	Approved	[438]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[439]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[347]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[440]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[441]

Drug(s) Affected By T-cell-specific surface glycoprotein CD28 (CD28)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[104]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[442]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[77]
GSK618334	DMJPXZ4	Drug abuse	6C4G.1Z	Phase 1	[443]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[69]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[84]

Drug(s) Affected By Golgi SNAP receptor complex member 1 (GOSR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[172]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[47]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[172]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[335]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[444]
Hexadecanoic acid	DMWUXDZ	Discovery agent	N.A.	Investigative	[445]

Drug(s) Affected By Carbamoyl-phosphate synthase , mitochondrial (CPS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[210]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[446]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[106]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[447]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[64]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[448]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[449]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[347]
Flucloxacillin	DMNUWST	Bacterial infection	1A00-1C4Z	Approved	[450]

Drug(s) Affected By Y+L amino acid transporter 1 (SLC7A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[210]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[127]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[451]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[435]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[71]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[292]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[65]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[452]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[313]

Drug(s) Affected By Insulin (INS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[453]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[104]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[454]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[455]
Fructose	DM43AN2	Vomiting	MD90	Approved	[456]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[457]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[458]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[459]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[460]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[461]

Drug(s) Affected By Endothelin-1 (EDN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[462]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[463]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[219]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[464]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[465]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[466]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[467]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[468]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Guanylate cyclase (GC)	TT6HPVC	NOUNIPROTAC	Stimulator	[6]
Soluble guanylate cyclase (GCS)	TT23PYC	GCYA1_HUMAN; GCYB1_HUMAN	Stimulator	[7]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Alanine/serine/cysteine/threonine transporter 2 (SLC1A5)	DTW7AE3	AAAT_HUMAN	Substrate	[8]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Angiotensinogen (AGT)	OTBZLYR3	ANGT_HUMAN	Regulation of Drug Effects	[9]
Annexin A5 (ANXA5)	OTZS877V	ANXA5_HUMAN	Gene/Protein Processing	[10]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[11]
Apoptosis-inducing factor 1, mitochondrial (AIFM1)	OTKPWB7Q	AIFM1_HUMAN	Protein Interaction/Cellular Processes	[11]
Baculoviral IAP repeat-containing protein 3 (BIRC3)	OT3E95KB	BIRC3_HUMAN	Gene/Protein Processing	[11]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Gene/Protein Processing	[11]
Bcl-2-binding component 3, isoforms 3/4 (BBC3)	OTUAXDAY	BBC3B_HUMAN	Gene/Protein Processing	[11]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Gene/Protein Processing	[11]
Beta-2-microglobulin (B2M)	OTDWN6NX	B2MG_HUMAN	Gene/Protein Processing	[12]
Beta-galactosidase (GLB1)	OTB0TKAG	BGAL_HUMAN	Gene/Protein Processing	[13]

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