Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDTVYC)

• Drug Name: DNCB Drug Info
• Synonyms: 1-Chloro-2,4-dinitrobenzene

Indication

Disease Entry	ICD 11	Status	REF
Immune System disease	4A01-4B41	Phase 2	[1]

• Cross-matching ID:
  PubChem CID: 6
  ChEBI ID: CHEBI:34718
  CAS Number: CAS 97-00-7
  TTD Drug ID: DMDTVYC
  INTEDE Drug ID: DR1928

Molecule-Related Drug Atlas

Drug(s) Affected By Pirin (PIR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[9]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[10]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[11]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[12]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[13]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[13]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[15]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[16]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[17]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[18]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[19]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[19]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[21]
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[23]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[24]

Drug(s) Affected By Spectrin alpha chain, erythrocytic 1 (SPTA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[26]

Drug(s) Affected By Ferritin heavy chain (FTH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[27]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[28]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[29]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[34]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[35]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[13]

Drug(s) Affected By Annexin A1 (ANXA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[41]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[35]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[42]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[37]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[44]
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[45]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[46]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[47]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[37]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[49]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[52]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[53]
Fructose	DM43AN2	Vomiting	MD90	Approved	[54]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[55]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[56]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[57]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[58]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[60]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[61]

Drug(s) Affected By Annexin A2 (ANXA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[64]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[65]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[42]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[67]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]

Drug(s) Affected By Cathepsin B (CTSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[68]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[69]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Pyrimethamine	DM5X7VY	Malaria	1F40-1F45	Approved	[73]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[74]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[75]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[76]

Drug(s) Affected By Rho-related GTP-binding protein RhoC (RHOC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[79]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[84]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[85]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[86]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[87]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[17]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[44]
Selenium	DM25CGV	N. A.	N. A.	Approved	[88]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[89]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[90]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[91]

Drug(s) Affected By Sucrase-isomaltase, intestinal (SI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[92]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[93]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[94]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[13]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[95]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[27]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[96]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[29]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[97]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[46]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[98]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[37]

Drug(s) Affected By Heat shock 70 kDa protein 6 (HSPA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[85]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[57]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[102]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]

Drug(s) Affected By Dual specificity protein phosphatase 1 (DUSP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[105]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[57]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[44]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[106]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[107]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[108]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[109]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[12]

Drug(s) Affected By Adenosine receptor A2b (ADORA2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[115]

Drug(s) Affected By Myristoylated alanine-rich C-kinase substrate (MARCKS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[45]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[116]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]

Drug(s) Affected By Metalloproteinase inhibitor 3 (TIMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[120]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[121]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[91]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[122]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[10]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[123]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[124]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[125]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[126]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[58]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[127]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[128]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[129]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[130]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[131]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[132]

Drug(s) Affected By Protein S100-A10 (S100A10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[134]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[136]

Drug(s) Affected By Arginase-2, mitochondrial (ARG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[105]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[138]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[10]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[140]

Drug(s) Affected By Transmembrane glycoprotein NMB (GPNMB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[141]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[13]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[13]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[143]

Drug(s) Affected By Ninjurin-1 (NINJ1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[145]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[144]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[13]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[13]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[13]

Drug(s) Affected By Peroxisomal acyl-coenzyme A oxidase 2 (ACOX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[49]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[10]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[146]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[147]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[147]

Drug(s) Affected By Perilipin-2 (PLIN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[148]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[149]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[10]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[13]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[152]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[146]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]

Drug(s) Affected By Krueppel-like factor 6 (KLF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[105]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[153]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[132]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[154]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[39]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]

Drug(s) Affected By Semaphorin-4C (SEMA4C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[156]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[158]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[159]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
SB-431542	DM0YOXQ	Pulmonary fibrosis	CB03.4	Preclinical	[161]

Drug(s) Affected By Homeodomain-interacting protein kinase 2 (HIPK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[12]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[162]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]

Drug(s) Affected By Chloride intracellular channel protein 4 (CLIC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[163]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[85]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[164]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]

Drug(s) Affected By Interferon-related developmental regulator 1 (IFRD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[165]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[166]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[10]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[167]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[8]

Drug(s) Affected By Antizyme inhibitor 1 (AZIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[169]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[170]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[115]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[171]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[170]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[168]

Drug(s) Affected By Mitotic checkpoint serine/threonine-protein kinase BUB1 (BUB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[172]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[173]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[138]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]

Drug(s) Affected By Transcription factor MafK (MAFK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[174]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[175]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[171]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[177]

Drug(s) Affected By Cytohesin-interacting protein (CYTIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[119]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[143]
Bortezomib	DMNO38U	Leukemia		Approved	[178]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[179]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[180]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[181]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[142]

Drug(s) Affected By H/ACA ribonucleoprotein complex subunit DKC1 (DKC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[7]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[183]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[184]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[185]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[177]

Drug(s) Affected By Copine-3 (CPNE3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[164]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[178]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[156]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[158]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]

Drug(s) Affected By DnaJ homolog subfamily B member 6 (DNAJB6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[186]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[187]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[188]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[187]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[170]

Drug(s) Affected By Syntaxin-11 (STX11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[189]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[190]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[115]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[177]

Drug(s) Affected By Signal recognition particle subunit SRP72 (SRP72)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[191]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[189]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[192]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[193]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[194]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[195]

Drug(s) Affected By Coagulation factor XIII A chain (F13A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[196]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[197]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[198]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[199]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]

Drug(s) Affected By Tissue-type plasminogen activator (PLAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[201]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[202]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[203]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[91]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[204]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[122]
Fructose	DM43AN2	Vomiting	MD90	Approved	[205]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[9]

Drug(s) Affected By Carbonic anhydrase 2 (CA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetazolamide	DM1AF5U	Absence epilepsy		Approved	[206]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[207]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[116]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[208]
Topiramate	DM82Z30	Alcohol dependence	6C40.2	Approved	[209]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[124]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[210]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[211]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[57]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[212]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[213]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[11]
Selenium	DM25CGV	N. A.	N. A.	Approved	[214]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[215]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[216]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[217]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]

Drug(s) Affected By Glucocorticoid receptor (NR3C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[219]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[220]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[221]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[222]

Drug(s) Affected By Protein S100-B (S100B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[196]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[223]
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[224]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[225]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[158]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[158]

Drug(s) Affected By Myeloperoxidase (MPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[54]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[54]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[54]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[226]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[227]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[228]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[230]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[231]

Drug(s) Affected By Glycophorin-B (GYPB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[232]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[5]

Drug(s) Affected By Procathepsin L (CTSL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[116]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[233]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[234]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[235]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[236]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[233]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]

Drug(s) Affected By Interferon-induced protein with tetratricopeptide repeats 2 (IFIT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[141]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[124]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[238]

Drug(s) Affected By Transcriptional activator Myb (MYB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[239]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[240]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[241]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[239]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[242]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[243]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]

Drug(s) Affected By E3 SUMO-protein ligase EGR2 (EGR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[244]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[12]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[178]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[245]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[220]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[246]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[247]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[248]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[249]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[89]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[250]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[251]

Drug(s) Affected By Fos-related antigen 2 (FOSL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[252]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[124]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[13]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[13]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]

Drug(s) Affected By Platelet glycoprotein 4 (CD36)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[253]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[254]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[255]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[256]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[257]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[258]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[146]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[259]

Drug(s) Affected By Diamine acetyltransferase 1 (SAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[260]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[138]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[39]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[261]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[261]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]

Drug(s) Affected By Bone morphogenetic protein 6 (BMP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[19]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[262]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[19]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[19]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[19]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[19]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[263]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[19]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[124]

Drug(s) Affected By Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[7]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[264]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[265]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[193]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]

Drug(s) Affected By Insulin-like growth factor-binding protein 6 (IGFBP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[91]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[154]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[266]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[267]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[268]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[169]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[189]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]

Drug(s) Affected By Proteasome subunit alpha type-5 (PSMA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[186]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[10]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[269]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[12]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[189]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[270]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[158]

Drug(s) Affected By Thioredoxin-dependent peroxide reductase, mitochondrial (PRDX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[271]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[272]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[273]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[274]

Drug(s) Affected By Syndecan-2 (SDC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[275]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[169]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[143]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[276]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[277]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]

Drug(s) Affected By C-C chemokine receptor type 2 (CCR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[174]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[258]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[280]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[281]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[282]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]

Drug(s) Affected By T-lymphocyte activation antigen CD86 (CD86)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[283]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[284]
Kanamycin	DM2DMPO	Bacteremia	1A73	Approved	[285]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[286]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[285]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[11]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[285]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[124]

Drug(s) Affected By Signal transducer and activator of transcription 1-alpha/beta (STAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[165]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[287]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[45]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[288]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[289]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[290]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[291]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[45]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]

Drug(s) Affected By Prostaglandin E2 receptor EP3 subtype (PTGER3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[37]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[292]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[293]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[294]
Terbinafine	DMI6HUW	Fungal infection	1F29-1F2F	Approved	[295]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[293]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]

Drug(s) Affected By Nicotinamide phosphoribosyltransferase (NAMPT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[296]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[10]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[297]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[252]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[13]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[13]

Drug(s) Affected By Radiation-inducible immediate-early gene IEX-1 (IER3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[105]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[298]
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[166]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[10]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[39]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[41]

Drug(s) Affected By Large ribosomal subunit protein uL15 (RPL27A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[299]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[137]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[300]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[301]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[302]

Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[303]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[304]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[305]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[306]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[307]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[308]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[309]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[310]

Drug(s) Affected By Signal transducer and activator of transcription 5B (STAT5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[287]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[311]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[145]
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[312]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[313]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[314]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[170]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[315]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein A3 (HNRNPA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[12]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[316]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[317]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[318]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[319]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[320]

Drug(s) Affected By Dipeptidyl peptidase 1 (CTSC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[141]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[13]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[13]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[13]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[13]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[321]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[13]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]

Drug(s) Affected By Cadherin-8 (CDH8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[141]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[322]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[159]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[39]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]

Drug(s) Affected By ADP-ribosylation factor-like protein 4C (ARL4C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[323]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[196]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[136]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[143]
Bortezomib	DMNO38U	Leukemia		Approved	[178]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[324]

Drug(s) Affected By Protein BTG1 (BTG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[132]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[325]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[145]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[35]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]

Drug(s) Affected By Inward rectifier potassium channel 2 (KCNJ2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[326]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[327]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[190]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[327]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[328]

Drug(s) Affected By Small ribosomal subunit protein bS6m (MRPS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[124]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[329]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[171]

Drug(s) Affected By Tumor necrosis factor-inducible gene 6 protein (TNFAIP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[19]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[244]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[19]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[19]
Trihexyphenidyl	DMB19L8	Dystonia	8A02	Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[19]

Drug(s) Affected By Transcription initiation factor IIB (GTF2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[298]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[330]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[12]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[177]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[331]

Drug(s) Affected By Large neutral amino acids transporter small subunit 1 (SLC7A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[239]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[298]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[332]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[10]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[39]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[333]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[239]

Drug(s) Affected By Kinesin-like protein KIF23 (KIF23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[138]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[334]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]

Drug(s) Affected By cAMP-responsive element modulator (CREM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[335]
Bortezomib	DMNO38U	Leukemia		Approved	[178]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[336]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[184]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]

Drug(s) Affected By Recombining binding protein suppressor of hairless (RBPJ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[326]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[337]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[338]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[324]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[147]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[147]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[339]

Drug(s) Affected By 3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[11]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[41]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[340]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[143]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[341]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[342]

Drug(s) Affected By Regulator of G-protein signaling 1 (RGS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[343]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[196]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[197]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[344]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[345]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[342]

Drug(s) Affected By Peroxisomal bifunctional enzyme (EHHADH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[346]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[346]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[347]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[348]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[235]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[346]

Drug(s) Affected By 3',5'-cyclic-AMP phosphodiesterase 4D (PDE4D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[326]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[39]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[349]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]

Drug(s) Affected By Dihydropyrimidine dehydrogenase (DPYD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[350]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[351]
Tegafur	DM31ZQM	Solid tumour/cancer	2A00-2F9Z	Approved	[352]
Flucytosine	DM13VTW	Cryptococcal meningitis		Approved	[54]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[49]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]

Drug(s) Affected By Phosphatidylinositol-binding clathrin assembly protein (PICALM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[326]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[330]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[317]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[353]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[354]

Drug(s) Affected By Ras-related protein Rab-32 (RAB32)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[355]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[356]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[357]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]

Drug(s) Affected By Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[358]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[359]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[166]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[10]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]

Drug(s) Affected By Fibroleukin (FGL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[343]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[244]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[143]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[276]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[360]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[225]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[361]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[362]

Drug(s) Affected By Structural maintenance of chromosomes protein 1A (SMC1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[172]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[363]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[364]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[308]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[12]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[363]
Bortezomib	DMNO38U	Leukemia		Approved	[178]

Drug(s) Affected By Signal transducer and activator of transcription 4 (STAT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[45]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[12]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[365]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[366]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[45]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[45]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[45]

Drug(s) Affected By Disks large-associated protein 5 (DLGAP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[138]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[13]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[13]

Drug(s) Affected By Homeobox protein TGIF1 (TGIF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[367]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[145]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[368]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[318]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]

Drug(s) Affected By Calcitonin gene-related peptide type 1 receptor (CALCRL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[162]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[158]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[158]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
PMID27336223-Compound-5	DM6E50A	N. A.	N. A.	Patented	[162]

Drug(s) Affected By Neuronal regeneration-related protein (NREP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[86]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[323]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[13]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[13]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[13]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]

Drug(s) Affected By Ceramide kinase-like protein (CERKL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[326]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[369]

Drug(s) Affected By UMP-CMP kinase 2, mitochondrial (CMPK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[370]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[365]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[341]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[170]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[156]

Drug(s) Affected By OTU domain-containing protein 1 (OTUD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[330]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[371]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[341]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[159]

Drug(s) Affected By Pyrin and HIN domain-containing protein 1 (PYHIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[41]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[372]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[373]

Drug(s) Affected By Embigin (EMB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[124]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[374]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[194]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[5]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[375]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[369]

Drug(s) Affected By ATP-binding cassette sub-family A member 6 (ABCA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[365]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[345]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[292]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[376]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[171]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[377]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[378]

Drug(s) Affected By SERPINE1 mRNA-binding protein 1 (SERBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[7]

Drug(s) Affected By Monocarboxylate transporter 10 (SLC16A10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[143]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[235]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[43]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[158]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[159]

Drug(s) Affected By Pleckstrin homology-like domain family A member 1 (PHLDA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[105]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[41]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[365]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[119]

Drug(s) Affected By Interactor protein for cytohesin exchange factors 1 (IPCEF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[162]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[159]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[372]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[194]
PMID27336223-Compound-5	DM6E50A	N. A.	N. A.	Patented	[162]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[5]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[379]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[326]

Drug(s) Affected By Lipid transferase CIDEC (CIDEC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[149]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[380]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[84]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[8]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[381]
Tributylstannanyl	DMHN7CB	Discovery agent	N.A.	Investigative	[382]

Drug(s) Affected By Splicing factor 45 (RBM17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[164]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[383]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[7]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[384]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[384]

Drug(s) Affected By Nuclear pore complex protein Nup88 (NUP88)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[195]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[318]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[385]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[177]

Drug(s) Affected By Membrane-spanning 4-domains subfamily A member 7 (MS4A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[196]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[344]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[362]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[386]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[5]
MICROCYSTIN-LR	DMTMLRN	Discovery agent	N.A.	Investigative	[387]

Drug(s) Affected By dCTP pyrophosphatase 1 (DCTPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[170]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[353]

Drug(s) Affected By Melanoma-associated antigen F1 (MAGEF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[335]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[7]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[171]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[177]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[302]

Drug(s) Affected By Protein C12orf4 (FERRY3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[115]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[158]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[177]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[70]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[386]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[194]

Drug(s) Affected By Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[193]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[194]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[388]

Drug(s) Affected By Bcl-2-associated transcription factor 1 (BCLAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[195]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[389]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[316]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[390]

Drug(s) Affected By CDGSH iron-sulfur domain-containing protein 1 (CISD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[335]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[356]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[193]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[177]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]

Drug(s) Affected By Large ribosomal subunit protein bL35m (MRPL35)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[169]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[356]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[70]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[194]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[5]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[391]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[392]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[142]

Drug(s) Affected By SLAM family member 8 (SLAMF8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[196]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[386]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[326]

Drug(s) Affected By HEAT repeat-containing protein 5B (HEATR5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[393]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[177]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[394]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[5]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[26]

Drug(s) Affected By F-box only protein 9 (FBXO9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[10]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[318]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[171]

Drug(s) Affected By Dermatan-sulfate epimerase (DSE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[12]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[143]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[395]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[353]

Drug(s) Affected By Malignant T-cell-amplified sequence 1 (MCTS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[396]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[10]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[397]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]

Drug(s) Affected By Sorting nexin-9 (SNX9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[124]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[7]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[193]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[158]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[171]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[177]

Drug(s) Affected By Peroxiredoxin-2 (PRDX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[398]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[399]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[400]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[10]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[401]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[67]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]

Drug(s) Affected By Peroxiredoxin-1 (PRDX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[402]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[399]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[91]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[49]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[266]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[34]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[144]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[403]

Drug(s) Affected By Kelch-like ECH-associated protein 1 (KEAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[404]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[405]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[406]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[13]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[13]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[13]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[403]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[389]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[407]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[27]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[408]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[409]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[408]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[408]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[408]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[410]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[411]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[412]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[413]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[414]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[415]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[416]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[417]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[220]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[19]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[418]

Drug(s) Affected By C-X-C chemokine receptor type 4 (CXCR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[69]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[45]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[419]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[420]
Carfilzomib	DM48K0X	Multiple myeloma	2A83	Approved	[421]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[45]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[422]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[423]

Drug(s) Affected By Liver carboxylesterase 1 (CES1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[424]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[126]
Dextropropoxyphene	DM23HCX	Pain	MG30-MG3Z	Approved	[425]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[426]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[427]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[428]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[429]

Drug(s) Affected By Gremlin-1 (GREM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[244]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[124]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[430]

Drug(s) Affected By Zinc finger protein SNAI1 (SNAI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[220]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[431]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[432]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[433]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[434]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[435]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[436]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[437]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[126]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[438]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[57]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[438]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[212]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[298]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[439]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[440]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[441]

Drug(s) Affected By Pro-epidermal growth factor (EGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[442]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[443]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[444]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[445]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]

Drug(s) Affected By Calcitonin (CALCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[446]
Fructose	DM43AN2	Vomiting	MD90	Approved	[205]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[191]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[317]
Nizatidine	DMGFV3Z	Acid-reflux disorder	DA22	Approved	[446]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[447]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[448]

Drug(s) Affected By C-X-C motif chemokine 10 (CXCL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[284]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[251]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[266]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[449]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[450]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[393]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[451]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]

Drug(s) Affected By Interstitial collagenase (MMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[172]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[452]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[453]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[454]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[91]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[455]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[456]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[122]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[457]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[11]

Drug(s) Affected By Stromelysin-1 (MMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[54]
Fluvastatin	DM4MDJY	Arteriosclerosis	BD40	Approved	[54]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[54]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[54]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[16]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[454]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[458]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[459]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[122]

Drug(s) Affected By Growth-regulated alpha protein (CXCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[105]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[37]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[9]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[45]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[9]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[460]

Drug(s) Affected By Interferon regulatory factor 1 (IRF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[91]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[145]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[35]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[124]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[169]

Drug(s) Affected By C-X-C motif chemokine 2 (CXCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[105]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[45]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[244]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[461]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[365]

Drug(s) Affected By Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[462]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[105]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[463]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[462]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[464]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[167]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[465]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[462]

Drug(s) Affected By Fibroblast growth factor 9 (FGF9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[466]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[143]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[276]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[366]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[324]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[156]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[467]

Drug(s) Affected By Regulator of G-protein signaling 2 (RGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[154]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[275]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[12]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[468]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[365]

Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[27]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[44]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[469]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[470]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[471]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[472]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[473]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[188]

Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[27]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[470]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[474]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[10]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[187]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[333]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[323]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[475]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1C (CDKN1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[154]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[240]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[9]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[9]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[365]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[178]

Drug(s) Affected By Nuclear receptor subfamily 0 group B member 1 (NR0B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[220]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[365]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[225]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[220]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[476]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]

Drug(s) Affected By Interleukin-1 receptor-like 1 (IL1RL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[477]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[478]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[479]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[300]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[171]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[477]

Drug(s) Affected By DNA-binding protein inhibitor ID-2 (ID2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[249]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[480]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[166]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[187]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[11]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[249]

Drug(s) Affected By BMP and activin membrane-bound inhibitor homolog (BAMBI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[323]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[41]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]

Drug(s) Affected By Metallothionein-2 (MT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[481]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[105]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[482]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[483]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[266]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[187]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[252]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[13]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[484]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[485]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[486]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[487]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[488]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[266]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[489]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[490]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[491]

Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[492]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[493]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[494]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[492]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[495]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[492]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[496]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]

Drug(s) Affected By Transcription factor MafF (MAFF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[27]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[220]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[494]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[49]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[10]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[174]

Drug(s) Affected By Transcription factor MafG (MAFG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[27]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[174]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[13]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]

Drug(s) Affected By Aldo-keto reductase family 1 member B10 (AKR1B10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[470]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[149]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[497]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[450]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[41]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[498]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[365]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[6]

Drug(s) Affected By Glutathione reductase, mitochondrial (GSR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[499]
Ketoprofen	DMRKXPT	Bursitis		Approved	[54]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[500]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[501]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[470]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[502]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[503]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[187]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[163]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[504]
Haloperidol	DM96SE0	Delirium		Approved	[54]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[69]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[58]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[505]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[506]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[507]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[47]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[508]

Drug(s) Affected By Ferritin light chain (FTL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[27]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[405]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[509]

Drug(s) Affected By Catalase (CAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[510]
Haloperidol	DM96SE0	Delirium		Approved	[54]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[500]
Selenium	DM25CGV	N. A.	N. A.	Approved	[511]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[512]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[513]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[514]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]

Drug(s) Affected By Extracellular superoxide dismutase (SOD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[400]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[515]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[196]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[143]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[499]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[516]

Drug(s) Affected By Microsomal glutathione S-transferase 1 (MGST1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[469]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[34]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[12]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[517]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[143]

Drug(s) Affected By Glucose-6-phosphate 1-dehydrogenase (G6PD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[395]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[54]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[164]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[220]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[501]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[470]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[9]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[10]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[518]

Drug(s) Affected By Aldo-keto reductase family 1 member B1 (AKR1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[167]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[519]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[143]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[6]

Drug(s) Affected By Glutathione peroxidase 3 (GPX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[27]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[49]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[10]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[191]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[520]

Drug(s) Affected By Ferrochelatase, mitochondrial (FECH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[298]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[521]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[13]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[13]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[13]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[143]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[6]

Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[492]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[493]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[522]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[522]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[492]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[492]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[523]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[524]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]

Drug(s) Affected By NADP-dependent malic enzyme (ME1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[27]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[470]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[10]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[323]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[13]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[13]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[6]

Drug(s) Affected By 6-phosphogluconate dehydrogenase, decarboxylating (PGD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[10]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Methylene blue	DMJAPE7	Acquired methemoglobinemia	3A93	Approved	[525]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[6]

Drug(s) Affected By Metallothionein-1X (MT1X)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[85]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[526]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[187]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]

Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[527]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[492]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[493]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[489]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[492]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[492]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[154]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[528]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[489]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[492]

Drug(s) Affected By Prostaglandin reductase 1 (PTGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[27]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[529]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[6]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[191]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]

Drug(s) Affected By Sulfiredoxin-1 (SRXN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[27]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[450]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[464]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[166]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[13]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[13]

Drug(s) Affected By Interleukin-7 receptor subunit alpha (IL7R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[364]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[145]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[35]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[124]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[345]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[530]

Drug(s) Affected By C-C chemokine receptor type 7 (CCR7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[35]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[531]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[532]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[531]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[147]

Drug(s) Affected By C-C chemokine receptor type 5 (CCR5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[533]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[534]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[535]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[536]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[537]
I3C	DMIGFOR	Breast cancer	2C60-2C65	Phase 3	[538]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[539]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[537]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[534]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[142]

Drug(s) Affected By Signaling lymphocytic activation molecule (SLAMF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[99]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[225]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[372]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[345]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[142]

Drug(s) Affected By Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[85]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[540]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[541]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[542]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[543]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[187]

Drug(s) Affected By Extended synaptotagmin-2 (ESYT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Bortezomib	DMNO38U	Leukemia		Approved	[178]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[7]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[156]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]

Drug(s) Affected By CCR4-NOT transcription complex subunit 1 (CNOT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[156]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[184]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[195]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[544]

Drug(s) Affected By Toll-like receptor 4 (TLR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[286]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[545]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[12]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[546]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[547]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[286]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[13]

Drug(s) Affected By Hyaluronan synthase 3 (HAS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[141]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[12]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[365]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[478]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[115]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[177]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[39]

Drug(s) Affected By 26S proteasome non-ATPase regulatory subunit 11 (PSMD11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[195]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[405]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[321]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[548]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[190]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[549]

Drug(s) Affected By Chloride intracellular channel protein 1 (CLIC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[550]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[403]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[169]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[551]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[552]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[156]

Drug(s) Affected By Coatomer subunit epsilon (COPE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[385]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[70]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[194]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[195]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[195]

Drug(s) Affected By AP-3 complex subunit delta-1 (AP3D1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[156]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[553]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[394]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[194]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[195]

Drug(s) Affected By Guanine nucleotide exchange factor DBS (MCF2L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[326]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[275]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[342]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[7]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[156]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]

Drug(s) Affected By Actin-related protein 2/3 complex subunit 2 (ARPC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[35]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[339]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[554]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[555]

Drug(s) Affected By Actin-related protein 2/3 complex subunit 3 (ARPC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[396]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[296]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[556]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[158]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[555]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[194]

Drug(s) Affected By Importin-8 (IPO8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[557]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[549]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[141]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[26]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[375]

Drug(s) Affected By Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (PAPSS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[396]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[558]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Vitamin C	DMXJ7O8	Adenocarcinoma	2D40	Approved	[558]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[559]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[560]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[194]

Drug(s) Affected By Eukaryotic translation initiation factor 4 gamma 3 (EIF4G3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[170]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[561]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[170]

Drug(s) Affected By NADH dehydrogenase 1 alpha subcomplex subunit 2 (NDUFA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[550]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[356]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[184]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[562]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[194]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[563]

Drug(s) Affected By Unconventional myosin-Ib (MYO1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[396]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[564]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[354]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[299]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]

Drug(s) Affected By Nardilysin (NRDC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[169]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[565]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[565]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[375]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[566]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[567]
Tributylstannanyl	DMHN7CB	Discovery agent	N.A.	Investigative	[565]

Drug(s) Affected By Origin recognition complex subunit 5 (ORC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[126]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[353]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[354]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[177]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[194]

Drug(s) Affected By RNA helicase aquarius (AQR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[170]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[156]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[395]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[170]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[386]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[326]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[375]

Drug(s) Affected By TBC1 domain family member 4 (TBC1D4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[143]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[568]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[319]

Drug(s) Affected By Periplakin (PPL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[39]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[143]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[235]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[569]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]

Drug(s) Affected By Long-chain-fatty-acid--CoA ligase 4 (ACSL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[359]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[401]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[146]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]

Drug(s) Affected By Protein diaphanous homolog 1 (DIAPH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[244]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[318]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[115]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[329]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[194]

Drug(s) Affected By Sorting nexin-2 (SNX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[198]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[335]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[389]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[194]

Drug(s) Affected By Filamin-B (FLNB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[570]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[316]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[561]

Drug(s) Affected By Splicing factor 3B subunit 1 (SF3B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[396]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[571]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[395]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[385]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[70]

Drug(s) Affected By Ribosomal protein S6 kinase alpha-5 (RPS6KA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[126]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[572]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[124]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[573]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[341]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]

Drug(s) Affected By PR domain zinc finger protein 1 (PRDM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[39]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[41]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[35]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[13]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[13]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[13]
Ibrutinib	DMHZCPO	Mantle cell lymphoma	2A85.5	Approved	[574]

Drug(s) Affected By Nuclear pore complex protein Nup155 (NUP155)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[335]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[115]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]

Drug(s) Affected By Eukaryotic translation initiation factor 3 subunit G (EIF3G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[269]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[195]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[26]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[575]

Drug(s) Affected By Unconventional myosin-Id (MYO1D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[39]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[156]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[395]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[385]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[177]

Drug(s) Affected By Pre-mRNA-processing factor 6 (PRPF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[365]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[164]
Bortezomib	DMNO38U	Leukemia		Approved	[178]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[193]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[158]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[70]

Drug(s) Affected By RAS guanyl-releasing protein 1 (RASGRP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[143]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[576]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]
Indomethacin	DMSC4A7	Bursitis		Approved	[577]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[569]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[225]

Drug(s) Affected By Importin-7 (IPO7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[252]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[557]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[335]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[7]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[318]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[232]

Drug(s) Affected By Keratin, type II cytoskeletal 75 (KRT75)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[9]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[9]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[9]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[578]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[156]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[199]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[579]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
all-trans-4-oxo-retinoic acid	DMM2R1N	Discovery agent	N.A.	Investigative	[9]

Drug(s) Affected By C-X-C motif chemokine 14 (CXCL14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[141]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[143]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[478]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[580]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]
Indomethacin	DMSC4A7	Bursitis		Approved	[577]

Drug(s) Affected By Serine/threonine-protein kinase OSR1 (OXSR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[581]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[544]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[582]

Drug(s) Affected By AP-2 complex subunit alpha-1 (AP2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Bortezomib	DMNO38U	Leukemia		Approved	[178]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[156]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[395]
SB-431542	DM0YOXQ	Pulmonary fibrosis	CB03.4	Preclinical	[161]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[388]

Drug(s) Affected By Double-stranded RNA-binding protein Staufen homolog 1 (STAU1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[169]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[556]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[177]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[195]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[544]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[583]

Drug(s) Affected By Apoptosis-inducing factor 1, mitochondrial (AIFM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[326]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[396]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[540]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[584]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[585]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[10]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[586]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[587]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[588]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]

Drug(s) Affected By Protein ecdysoneless homolog (ECD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[405]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[156]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[177]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[589]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[195]

Drug(s) Affected By Mitochondrial import receptor subunit TOM40 homolog (TOMM40)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[590]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[115]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[177]
Fenretinide	DMRD5SP	Macular degeneration	9B78.3	Phase 3	[591]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[592]

Drug(s) Affected By Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[593]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[594]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[595]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[596]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[597]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[598]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[57]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[396]
Selenium	DM25CGV	N. A.	N. A.	Approved	[120]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[599]

Drug(s) Affected By Argininosuccinate synthase (ASS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[564]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[119]

Drug(s) Affected By Complement C3 (C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[220]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[37]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[149]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[10]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[515]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[600]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[37]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[601]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[602]
Fructose	DM43AN2	Vomiting	MD90	Approved	[54]
Ketoprofen	DMRKXPT	Bursitis		Approved	[54]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[370]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[603]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[604]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[605]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[606]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[247]

Drug(s) Affected By Interleukin-1 alpha (IL1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[105]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[19]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[19]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[247]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[19]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[308]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[19]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[266]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]

Drug(s) Affected By Keratin, type I cytoskeletal 14 (KRT14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[607]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[9]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[9]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[608]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[609]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[9]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[610]
Methamphetamine	DMPM4SK	Anxiety		Approved	[611]

Drug(s) Affected By Keratin, type II cytoskeletal 6A (KRT6A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[607]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[9]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[9]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[196]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[612]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[344]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[9]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[613]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[192]

Drug(s) Affected By Prelamin-A/C (LMNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[91]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[614]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[615]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[616]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[12]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[429]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]

Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[54]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[617]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[618]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[619]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[620]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[621]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[622]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[623]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[624]

Drug(s) Affected By Estrogen receptor (ESR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[625]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[626]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[627]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[628]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[596]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[629]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[630]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[631]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[628]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[632]

Drug(s) Affected By Keratin, type II cytoskeletal 6B (KRT6B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[607]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[196]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[184]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[300]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[633]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[374]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
PD-153035	DM7KJTI	Psoriasis vulgaris	EA90	Discontinued in Phase 1	[607]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[634]

Drug(s) Affected By Heat shock protein beta-1 (HSPB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[68]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[187]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[564]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[12]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[635]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[158]

Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[636]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[201]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[637]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[638]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[639]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[49]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[640]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[174]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[123]

Drug(s) Affected By ADP/ATP translocase 2 (SLC25A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[571]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[273]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[7]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[356]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[54]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[45]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[641]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[105]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[86]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[245]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[17]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[247]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[21]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[469]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[45]

Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[642]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[642]
Ergonovine	DM0VEC1	Postpartum haemorrhage	JA43	Approved	[54]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[643]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[644]
Mizolastine	DM1FDN8	Allergic rhinitis	CA08.0	Approved	[645]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[646]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[647]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[648]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[89]

Drug(s) Affected By Protein kinase C beta type (PRKCB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[649]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[615]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[323]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[614]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[649]

Drug(s) Affected By Glycogen phosphorylase, liver form (PYGL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[191]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[13]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[13]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[292]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]

Drug(s) Affected By Glucose-6-phosphate isomerase (GPI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[358]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[403]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[164]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[164]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]

Drug(s) Affected By Beta-hexosaminidase subunit alpha (HEXA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[169]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[236]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[54]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
PP-242	DM2348V	Discovery agent	N.A.	Investigative	[650]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[651]

Drug(s) Affected By Protein disulfide-isomerase (P4HB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[253]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[399]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[253]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[49]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[253]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[187]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[253]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]

Drug(s) Affected By Involucrin (IVL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[652]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[653]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[654]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[652]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[655]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[656]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[69]

Drug(s) Affected By Prosaposin (PSAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[657]
Bortezomib	DMNO38U	Leukemia		Approved	[178]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[318]

Drug(s) Affected By Bifunctional glutamate/proline--tRNA ligase (EPRS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[13]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[13]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[13]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[13]

Drug(s) Affected By Heterogeneous nuclear ribonucleoproteins C1/C2 (HNRNPC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[396]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Tetracaine	DM9J6C2	Spinal anesthesia	MB40.3	Approved	[658]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[659]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]

Drug(s) Affected By Keratin, type I cytoskeletal 16 (KRT16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[652]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[607]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[10]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[124]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[660]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[578]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]

Drug(s) Affected By Glutathione S-transferase P (GSTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[661]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[662]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[662]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[663]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[27]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[298]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[399]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[664]

Drug(s) Affected By Dihydrolipoyl dehydrogenase, mitochondrial (DLD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[10]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[665]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[105]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[666]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[667]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[540]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[668]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[131]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[668]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[669]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[670]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[671]

Drug(s) Affected By Heat shock 70 kDa protein 1A (HSPA1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[672]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[85]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[57]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[18]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[399]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[266]

Drug(s) Affected By Chimeric ERCC6-PGBD3 protein (ERCC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[172]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[673]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[674]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[673]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[675]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[676]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[677]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[678]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[679]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[680]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[86]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[56]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[17]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[19]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[681]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[19]

Drug(s) Affected By C-C motif chemokine 3 (CCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[245]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[266]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[296]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[244]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[682]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[683]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[683]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[245]

Drug(s) Affected By HLA class I histocompatibility antigen, C alpha chain (HLA-C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[684]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[685]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[686]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[225]
Ticlopidine	DMO946V	Acute coronary syndrome	BA41	Approved	[687]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[298]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[323]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[182]

Drug(s) Affected By cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[396]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[499]
Mitotane	DMU1GX0	Adrenocortical carcinoma	2D11.Z	Approved	[688]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[689]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[690]

Drug(s) Affected By S-formylglutathione hydrolase (ESD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[191]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[335]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
NVP-AUY922	DMTYXQF	Multiple myeloma	2A83	Phase 2	[691]

Drug(s) Affected By 60 kDa heat shock protein, mitochondrial (HSPD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[165]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[399]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[615]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[266]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[692]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[10]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[187]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[188]

Drug(s) Affected By Proto-oncogene DBL (MCF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[149]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[190]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[156]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[577]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]

Drug(s) Affected By Heat shock cognate 71 kDa protein (HSPA8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[303]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[57]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[165]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[396]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[399]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[615]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[296]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[269]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[693]

Drug(s) Affected By Pyruvate dehydrogenase E1 component subunit beta, mitochondrial (PDHB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[10]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[35]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[694]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[695]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[385]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[391]

Drug(s) Affected By C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[147]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[147]

Drug(s) Affected By Neurofilament heavy polypeptide (NEFH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[696]
Scopolamine	DMOM8AL	Addictive disorder	6C50-6C5Z	Approved	[697]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[322]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[698]

Drug(s) Affected By Nucleoprotein TPR (TPR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[195]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[699]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[164]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[164]

Drug(s) Affected By Annexin A3 (ANXA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[154]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[39]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[41]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[37]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]

Drug(s) Affected By Ski-like protein (SKIL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[147]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[328]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]

Drug(s) Affected By Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[700]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[701]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[702]
Mitotane	DMU1GX0	Adrenocortical carcinoma	2D11.Z	Approved	[703]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[704]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[54]

Drug(s) Affected By C-C motif chemokine 4 (CCL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[266]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[682]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[35]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[683]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[365]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[683]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]

Drug(s) Affected By Lysosome-associated membrane glycoprotein 2 (LAMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[291]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[395]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[705]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[706]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[707]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[385]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[39]

Drug(s) Affected By C-C motif chemokine 5 (CCL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[58]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[708]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[284]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[533]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[449]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[682]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[263]

Drug(s) Affected By Keratin, type II cytoskeletal 5 (KRT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[607]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[9]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[9]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[608]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[196]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[612]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[9]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[610]

Drug(s) Affected By Protein disulfide-isomerase A4 (PDIA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[335]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[709]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[556]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[171]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[354]

Drug(s) Affected By Pyruvate kinase PKM (PKM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[710]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[405]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[711]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[550]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[429]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[403]

Drug(s) Affected By Myosin light chain 6B (MYL6B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[252]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[292]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[147]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[147]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[376]

Drug(s) Affected By Insulin-degrading enzyme (IDE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[303]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[712]
Bortezomib	DMNO38U	Leukemia		Approved	[178]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[147]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[147]

Drug(s) Affected By Ezrin (EZR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[164]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[713]
Haloperidol	DM96SE0	Delirium		Approved	[164]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]

Drug(s) Affected By Fos-related antigen 1 (FOSL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[174]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[108]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[515]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[714]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[41]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[252]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]

Drug(s) Affected By Cyclic AMP-responsive element-binding protein 1 (CREB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[715]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[716]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[364]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[717]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[718]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[718]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[719]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[720]

Drug(s) Affected By Methylated-DNA--protein-cysteine methyltransferase (MGMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[721]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[116]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[588]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[722]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[723]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[724]
Dacarbazine	DMNPZL4	Adenocarcinoma	2D40	Approved	[725]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[726]

Drug(s) Affected By Atrial natriuretic peptide receptor 3 (NPR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[317]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[143]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[225]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[184]

Drug(s) Affected By ATP-dependent 6-phosphofructokinase, liver type (PFKL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Penfluridol	DMG1DTE	Schizophrenia	6A20	Approved	[727]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[70]
PP-242	DM2348V	Discovery agent	N.A.	Investigative	[650]

Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 1 (PTPN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[728]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[353]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[80]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[477]
URSOLIC ACID	DM4SOAW	Metabolic syndrome x	5C50-5D2Z	Phase 2	[729]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[394]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[85]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[330]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[730]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[154]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[482]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[149]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[187]

Drug(s) Affected By Keratin, type II cytoskeletal 4 (KRT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[612]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[731]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[115]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[732]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[733]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[84]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[713]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[57]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[734]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[298]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[735]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[507]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[288]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[228]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[308]

Drug(s) Affected By Filamin-A (FLNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[736]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[10]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[403]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[737]

Drug(s) Affected By Trifunctional purine biosynthetic protein adenosine-3 (GART)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[164]

Drug(s) Affected By Fibroblast growth factor receptor 3 (FGFR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[10]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[39]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[41]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[738]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[738]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[12]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[739]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]

Drug(s) Affected By Eukaryotic translation initiation factor 4B (EIF4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[740]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[694]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[741]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[7]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[168]

Drug(s) Affected By Low molecular weight phosphotyrosine protein phosphatase (ACP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[728]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[274]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[742]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[385]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[385]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[70]

Drug(s) Affected By DNA-directed RNA polymerase II subunit RPB1 (POLR2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[743]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[195]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[362]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[330]
Deferasirox	DM6ETS0	Beta thalassemia	3A50.2	Approved	[744]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]

Drug(s) Affected By C-X-C chemokine receptor type 1 (CXCR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[745]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[746]
Teriflunomide	DMQ2FKJ	Hyperlipidaemia	5C80	Approved	[747]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[748]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[749]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[750]
PBI-05204	DM05WIU	Pancreatic cancer	2C10	Phase 2	[751]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[70]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[752]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[374]

Drug(s) Affected By DNA replication licensing factor MCM3 (MCM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[172]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[308]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[108]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[252]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]

Drug(s) Affected By ATP synthase subunit alpha, mitochondrial (ATP5F1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[164]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[753]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[754]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[755]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[42]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[403]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[756]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[292]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 5 (CD40)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[16]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[286]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[757]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[550]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[758]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[286]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[759]

Drug(s) Affected By Moesin (MSN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[737]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[383]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]

Drug(s) Affected By Catenin alpha-2 (CTNNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[395]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[159]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[354]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[39]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[302]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[195]

Drug(s) Affected By DNA cytosine-5)-methyltransferase 1 (DNMT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[173]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[760]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[761]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[419]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[762]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[763]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[764]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[765]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[242]

Drug(s) Affected By Threonine--tRNA ligase 1, cytoplasmic (TARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[164]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[165]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[39]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[12]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[13]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[13]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[766]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[767]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[716]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[603]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[768]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[769]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[770]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[771]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[772]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[773]

Drug(s) Affected By Calnexin (CANX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[396]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[187]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[145]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[774]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[775]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[187]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[776]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[767]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[777]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[778]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[779]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[766]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[54]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[16]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[603]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[768]

Drug(s) Affected By Tripeptidyl-peptidase 2 (TPP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[780]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[780]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[780]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[781]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[782]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[141]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[544]

Drug(s) Affected By Transketolase (TKT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[470]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[405]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[10]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[783]

Drug(s) Affected By Caspase-1 (CASP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[16]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[18]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[784]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[21]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[648]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[343]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[405]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[116]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[785]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[406]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PPP2R1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[365]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[170]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[318]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[786]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[10]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[786]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[252]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[146]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[478]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[299]

Drug(s) Affected By Adenylosuccinate lyase (ADSL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[191]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[178]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[592]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[372]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[194]

Drug(s) Affected By Succinate dehydrogenase flavoprotein subunit, mitochondrial (SDHA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[12]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[787]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[788]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[789]

Drug(s) Affected By RAC-beta serine/threonine-protein kinase (AKT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[620]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[330]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[585]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[49]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[330]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[790]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[189]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[791]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[792]

Drug(s) Affected By Bifunctional purine biosynthesis protein ATIC (ATIC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[793]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[515]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[191]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[7]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[177]

Drug(s) Affected By Stress-induced-phosphoprotein 1 (STIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[68]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[794]
Haloperidol	DM96SE0	Delirium		Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[795]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[164]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[164]
Mecamylamine	DMGQFYB	Essential hypertension	BA00	Approved	[795]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[796]

Drug(s) Affected By Large ribosomal subunit protein uL6 (RPL9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[396]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[395]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[690]
Nabiximols	DMHKJ5I	Cancer related pain	MG30	Phase 3	[797]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[781]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[194]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[392]

Drug(s) Affected By Long-chain-fatty-acid--CoA ligase 1 (ACSL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[326]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[798]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[256]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[13]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[13]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[13]

Drug(s) Affected By DNA replication licensing factor MCM5 (MCM5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[172]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[108]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[141]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]

Drug(s) Affected By Catenin alpha-1 (CTNNA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[298]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[343]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[11]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[144]
Haloperidol	DM96SE0	Delirium		Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[169]

Drug(s) Affected By Radixin (RDX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Haloperidol	DM96SE0	Delirium		Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[568]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[53]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[192]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[385]

Drug(s) Affected By Pro-adrenomedullin (ADM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[126]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[799]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[800]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[365]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[84]

Drug(s) Affected By Myosin-9 (MYH9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[615]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[291]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[801]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[737]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[85]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[802]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[57]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[803]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[253]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[804]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[805]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[138]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]

Drug(s) Affected By Myosin-11 (MYH11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[806]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[612]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[119]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[276]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[190]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[147]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[147]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[807]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[156]

Drug(s) Affected By Keratin, type II cytoskeletal 2 epidermal (KRT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[478]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[366]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[690]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[808]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[809]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[195]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[810]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[811]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[145]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[401]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[174]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]

Drug(s) Affected By Malate dehydrogenase, mitochondrial (MDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[264]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[301]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[70]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[302]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[812]

Drug(s) Affected By Trifunctional enzyme subunit alpha, mitochondrial (HADHA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[149]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[335]
Bortezomib	DMNO38U	Leukemia		Approved	[178]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[70]

Drug(s) Affected By Glycine--tRNA ligase (GARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[734]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[291]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[252]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[13]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[13]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[13]

Drug(s) Affected By Isoleucine--tRNA ligase, cytoplasmic (IARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[244]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[330]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[252]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[13]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[13]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[13]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]

Drug(s) Affected By Lamina-associated polypeptide 2, isoform alpha (TMPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[165]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[195]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[141]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]

Drug(s) Affected By DNA mismatch repair protein Msh2 (MSH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[172]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[813]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[108]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[814]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[276]

Drug(s) Affected By Glycerol-3-phosphate dehydrogenase, mitochondrial (GPD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[91]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[815]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[164]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[156]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[816]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[55]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[605]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[44]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[60]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[308]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[692]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[817]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[60]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[818]

Drug(s) Affected By Proliferation marker protein Ki-67 (MKI67)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[819]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[138]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[195]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[820]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[108]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[821]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[822]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[12]

Drug(s) Affected By Probable 28S rRNA (NOP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[12]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[184]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[184]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[302]

Drug(s) Affected By Crk-like protein (CRKL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[823]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[824]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[825]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[826]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[193]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[827]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[394]
PMID25656651-Compound-5	DMAI95U	Chronic myeloid leukaemia	2A20	Patented	[828]

Drug(s) Affected By Ras GTPase-activating-like protein IQGAP1 (IQGAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[165]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[829]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[403]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[317]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]

Drug(s) Affected By Glycogenin-1 (GYG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[395]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[159]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]

Drug(s) Affected By F-actin-capping protein subunit alpha-2 (CAPZA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[145]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[169]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[318]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[795]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[302]

Drug(s) Affected By T-complex protein 1 subunit epsilon (CCT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[191]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[571]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[317]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[7]

Drug(s) Affected By Keratin, type II cytoskeletal 6C (KRT6C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[607]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[578]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[184]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[171]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
PD-153035	DM7KJTI	Psoriasis vulgaris	EA90	Discontinued in Phase 1	[607]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[830]

Drug(s) Affected By Fatty acid synthase (FASN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[831]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[620]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[253]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[832]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[358]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[49]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[833]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[9]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[834]

Drug(s) Affected By Deoxyhypusine synthase (DHPS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[835]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[795]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[169]

Drug(s) Affected By T-complex protein 1 subunit gamma (CCT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[396]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[269]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[403]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[571]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[302]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]

Drug(s) Affected By Alanine--tRNA ligase, cytoplasmic (AARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[269]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[13]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[13]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[169]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[164]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[13]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[147]

Drug(s) Affected By C-X-C chemokine receptor type 3 (CXCR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[54]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[836]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[837]
MLN4924	DMP36KD	Myelodysplastic syndrome	2A37	Phase 3	[838]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[374]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[142]
Nickel chloride	DMI12Y8	Discovery agent	N.A.	Investigative	[839]

Drug(s) Affected By DNA replication licensing factor MCM2 (MCM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[105]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[308]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[123]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[840]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]

Drug(s) Affected By RNA-binding protein 25 (RBM25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[699]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[318]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[158]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[795]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[158]

Drug(s) Affected By GMP synthase (GMPS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[269]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[335]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[394]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[195]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[195]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[841]

Drug(s) Affected By Rab GDP dissociation inhibitor beta (GDI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[695]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[335]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[7]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[156]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]

Drug(s) Affected By Emerin (EMD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[801]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[316]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[195]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[195]

Drug(s) Affected By Palmitoyl-protein thioesterase 1 (PPT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[842]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[335]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[842]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[395]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[560]

Drug(s) Affected By T-complex protein 1 subunit delta (CCT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[274]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[589]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[195]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[326]
Okadaic acid	DM47CO1	Discovery agent	N.A.	Investigative	[843]

Drug(s) Affected By Small ribosomal subunit protein mS29 (DAP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[844]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[571]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[189]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[845]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Bortezomib	DMNO38U	Leukemia		Approved	[846]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[366]

Drug(s) Affected By Dual specificity protein phosphatase 3 (DUSP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[657]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[147]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[147]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[7]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[339]

Drug(s) Affected By Peroxisomal multifunctional enzyme type 2 (HSD17B4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[847]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[847]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Haloperidol	DM96SE0	Delirium		Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[169]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[149]

Drug(s) Affected By Ribosomal protein S6 kinase alpha-3 (RPS6KA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[848]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[578]

Drug(s) Affected By Importin subunit alpha-1 (KPNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[165]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[396]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[849]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[557]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[850]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[851]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]

Drug(s) Affected By DNA mismatch repair protein Msh6 (MSH6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[172]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[132]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]

Drug(s) Affected By ATP-citrate synthase (ACLY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[253]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[419]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[149]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[10]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[852]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[853]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[198]
OPC-34712	DMHG57U	Major depressive disorder	6A70.3	Approved	[854]

Drug(s) Affected By Arginine--tRNA ligase, cytoplasmic (RARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[12]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[375]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[369]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[582]

Drug(s) Affected By Heat shock-related 70 kDa protein 2 (HSPA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[105]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[101]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[34]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[252]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]

Drug(s) Affected By NHP2-like protein 1 (SNU13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[336]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[590]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[70]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
PP-242	DM2348V	Discovery agent	N.A.	Investigative	[650]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[388]

Drug(s) Affected By NACHT, LRR and PYD domains-containing protein 12 (NLRP12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[800]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Bortezomib	DMNO38U	Leukemia		Approved	[800]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[156]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[181]

Drug(s) Affected By Actin, cytoplasmic 1 (ACTB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[298]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[399]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[855]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]

Drug(s) Affected By Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[396]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Amiloride	DMRTSGP	Congestive heart failure	BD10	Approved	[856]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[857]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[274]

Drug(s) Affected By 26S proteasome regulatory subunit 8 (PSMC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[365]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[164]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[194]
MG-132	DMKA2YS	N. A.	N. A.	Preclinical	[858]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[392]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[375]

Drug(s) Affected By Histone H4 (H4C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[105]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[330]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[859]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[40]

Drug(s) Affected By AP-2 complex subunit beta (AP2B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[10]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[330]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[12]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[169]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[324]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[54]

Drug(s) Affected By Hemoglobin subunit beta (HBB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[860]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[861]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Voxelotor	DMCS6M5	Sickle-cell disorder	3A51	Approved	[862]
Ibrutinib	DMHZCPO	Mantle cell lymphoma	2A85.5	Approved	[863]
Flucloxacillin	DMNUWST	Bacterial infection	1A00-1C4Z	Approved	[864]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[865]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[866]

Drug(s) Affected By Immunoglobulin-binding protein 1 (IGBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[115]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[169]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[177]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[194]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[326]
MICROCYSTIN-LR	DMTMLRN	Discovery agent	N.A.	Investigative	[867]

Drug(s) Affected By General transcription factor II-I (GTF2I)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[178]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[657]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[7]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[689]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[158]

Drug(s) Affected By DNA-dependent protein kinase catalytic subunit (PRKDC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[165]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[396]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[419]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[187]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[868]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[12]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[588]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]

Drug(s) Affected By Small ribosomal subunit protein uS5m (MRPS5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Bortezomib	DMNO38U	Leukemia		Approved	[178]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[869]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[356]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[158]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[301]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[870]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[583]

Drug(s) Affected By ADP-ribosylation factor 5 (ARF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[191]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[335]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[70]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[43]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[870]

Drug(s) Affected By Vigilin (HDLBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[195]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[871]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[39]

Drug(s) Affected By CD83 antigen (CD83)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[463]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[286]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[35]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[872]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[873]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]

Drug(s) Affected By Keratin, type II cytoskeletal 2 oral (KRT76)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]

Drug(s) Affected By DNA topoisomerase 2-beta (TOP2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[874]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[165]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[189]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[875]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[7]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[876]

Drug(s) Affected By Lamin-B2 (LMNB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[877]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[274]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[592]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[878]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[194]

Drug(s) Affected By CCAAT/enhancer-binding protein zeta (CEBPZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[879]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[879]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[115]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[879]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[16]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[880]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[881]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[228]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[614]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[882]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[883]

Drug(s) Affected By Keratin, type I cytoskeletal 17 (KRT17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[652]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[154]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[9]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[9]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[652]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[9]

Drug(s) Affected By Elongation factor 1-alpha 2 (EEF1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[884]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[365]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[164]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[885]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[430]

Drug(s) Affected By Protein phosphatase 3 catalytic subunit alpha (PPP3CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[291]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[886]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[164]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[143]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[324]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]

Drug(s) Affected By ATP-dependent RNA helicase A (DHX9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[165]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[571]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[335]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[887]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[7]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[336]

Drug(s) Affected By Golgin subfamily A member 2 (GOLGA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[317]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[341]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[888]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[554]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[354]

Drug(s) Affected By AP-1 complex subunit beta-1 (AP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[396]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[889]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[156]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[171]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[890]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]

Drug(s) Affected By Hyaluronidase-1 (HYAL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[317]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[891]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[891]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[171]

Drug(s) Affected By A-kinase anchor protein 13 (AKAP13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[561]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[892]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[193]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[893]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]

Drug(s) Affected By G-rich sequence factor 1 (GRSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[394]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[388]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[142]

Drug(s) Affected By Chromodomain-helicase-DNA-binding protein 3 (CHD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[195]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[147]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[372]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[232]

Drug(s) Affected By Interleukin enhancer-binding factor 3 (ILF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[318]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[356]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[158]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[168]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[301]

Drug(s) Affected By Unconventional myosin-Ie (MYO1E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[730]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[730]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[730]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[730]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[156]

Drug(s) Affected By Large ribosomal subunit protein bL28m (MRPL28)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[12]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[356]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[171]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[372]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]

Drug(s) Affected By S-methyl-5'-thioadenosine phosphorylase (MTAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[894]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[158]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 1 (MAP3K1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[308]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[196]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[189]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[895]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[896]

Drug(s) Affected By Serine/arginine-rich splicing factor 9 (SRSF9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[70]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[781]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[195]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[544]

Drug(s) Affected By Transcription intermediary factor 1-beta (TRIM28)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[164]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[897]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[195]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Haloperidol	DM96SE0	Delirium		Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[164]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[164]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PPP2R5C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[190]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[170]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[156]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[170]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[385]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[898]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[898]

Drug(s) Affected By NEDD8-activating enzyme E1 regulatory subunit (NAE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[291]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[899]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[392]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[375]

Drug(s) Affected By Ras GTPase-activating-like protein IQGAP2 (IQGAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[900]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[354]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[376]

Drug(s) Affected By KRR1 small subunit processome component homolog (KRR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[318]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[339]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[353]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[158]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[385]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[385]

Drug(s) Affected By Cullin-1 (CUL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[515]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Bortezomib	DMNO38U	Leukemia		Approved	[901]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[168]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]

Drug(s) Affected By Cullin-4A (CUL4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[396]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[296]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[143]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[324]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[7]

Drug(s) Affected By Interleukin-18 (IL18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[16]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[298]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[902]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[406]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[903]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[365]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[904]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[905]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[904]

Drug(s) Affected By Eukaryotic translation initiation factor 3 subunit A (EIF3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[170]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[499]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[395]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[9]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[9]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[119]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[164]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[906]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[835]

Drug(s) Affected By Golgin subfamily B member 1 (GOLGB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[252]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[907]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[164]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[335]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[225]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[354]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[177]

Drug(s) Affected By Chromodomain-helicase-DNA-binding protein 4 (CHD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[252]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[119]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[164]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[164]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]

Drug(s) Affected By Nucleolar and coiled-body phosphoprotein 1 (NOLC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[7]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[318]

Drug(s) Affected By Nuclear mitotic apparatus protein 1 (NUMA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[908]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[189]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[909]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[115]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[910]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[158]

Drug(s) Affected By 26S proteasome non-ATPase regulatory subunit 6 (PSMD6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[165]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[165]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[158]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[165]
MG-132	DMKA2YS	N. A.	N. A.	Preclinical	[858]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[392]

Drug(s) Affected By Splicing factor 3B subunit 3 (SF3B3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[754]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[164]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[690]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[326]
AMINOHIPPURIC ACID	DMUN54G	Discovery agent	N.A.	Investigative	[911]

Drug(s) Affected By Calponin-3 (CNN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[889]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[335]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[318]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[353]

Drug(s) Affected By Ribosomal protein S6 kinase alpha-1 (RPS6KA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[126]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[906]

Drug(s) Affected By Scaffold attachment factor B1 (SAFB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[326]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[164]
Bortezomib	DMNO38U	Leukemia		Approved	[178]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[220]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[302]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[194]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[195]

Drug(s) Affected By ELAV-like protein 1 (ELAVL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[912]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[913]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[191]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[913]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[914]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[395]
Amsacrine	DMZKYIV	Acute lymphoblastic leukaemia	2A85	Approved	[915]

Drug(s) Affected By Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (NSDHL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[359]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[10]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[143]

Drug(s) Affected By Ras-related protein Rab-30 (RAB30)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[41]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[225]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[219]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[177]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[916]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[68]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[87]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[57]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[20]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[917]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[97]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[46]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[918]

Drug(s) Affected By 26S proteasome non-ATPase regulatory subunit 5 (PSMD5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[169]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[177]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[194]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[388]

Drug(s) Affected By Mitogen-activated protein kinase 14 (MAPK14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[919]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[68]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[44]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[107]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[502]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[108]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[818]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[920]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[921]

Drug(s) Affected By Dihydropyrimidinase-related protein 2 (DPYSL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[922]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[10]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[403]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[164]

Drug(s) Affected By Fascin (FSCN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[923]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[405]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[116]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[564]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]

Drug(s) Affected By Regulator of G-protein signaling 21 (RGS21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]

Drug(s) Affected By GON-4-like protein (GON4L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[396]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[190]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[7]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[158]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[372]

Drug(s) Affected By Cytokine-like nuclear factor N-PAC (GLYR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[395]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[158]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[302]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[232]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[195]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[195]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[26]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[375]

Drug(s) Affected By Glycerol-3-phosphate acyltransferase 3 (GPAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[137]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[41]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[13]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[13]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[13]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[498]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[321]

Drug(s) Affected By Protein FAM76B (FAM76B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[894]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[158]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[177]

Drug(s) Affected By RNA-binding protein 26 (RBM26)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[158]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[302]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[394]

Drug(s) Affected By ATPase family AAA domain-containing protein 3B (ATAD3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[164]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[156]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[115]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[878]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[392]

Drug(s) Affected By 5'-nucleotidase domain-containing protein 1 (NT5DC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[907]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[812]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[194]

Drug(s) Affected By Rootletin (CROCC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[317]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[568]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[156]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[194]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[326]

Drug(s) Affected By Proteasome adapter and scaffold protein ECM29 (ECPAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Bortezomib	DMNO38U	Leukemia		Approved	[178]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[7]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[199]

Drug(s) Affected By Schlafen family member 12-like (SLFN12L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]

Drug(s) Affected By Activity-dependent neuroprotector homeobox protein 2 (ADNP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[168]
Lithium	DMZ3OU6	Bipolar disorder	6A60	Phase 2	[924]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[567]

Drug(s) Affected By Ankyrin repeat domain-containing protein 12 (ANKRD12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[11]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[699]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[907]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[341]

Drug(s) Affected By Nicotinate phosphoribosyltransferase (NAPRT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Daporinad	DMCU74R	leukaemia	2A60-2B33	Phase 2	[925]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[194]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[388]
OXYRESVERATROL	DMN7S4L	Discovery agent	N.A.	Investigative	[926]

Drug(s) Affected By CD109 antigen (CD109)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[16]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[156]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]

Drug(s) Affected By FERM domain-containing protein 7 (FRMD7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]

Drug(s) Affected By MOB kinase activator 1B (MOB1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[326]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[907]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[177]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[388]
crotylaldehyde	DMTWRQI	Discovery agent	N.A.	Investigative	[927]

Drug(s) Affected By Keratin, type II cytoskeletal 74 (KRT74)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[156]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[374]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[326]

Drug(s) Affected By CLIP-associating protein 1 (CLASP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[156]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[386]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[195]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[195]

Drug(s) Affected By Ankyrin repeat domain-containing protein 37 (ANKRD37)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[8]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[158]

Drug(s) Affected By Keratin, type II cytoskeletal 73 (KRT73)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[354]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[372]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[326]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[375]

Drug(s) Affected By Serine/arginine repetitive matrix protein 1 (SRRM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[195]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[12]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[556]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[158]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[302]

Drug(s) Affected By ELMO domain-containing protein 2 (ELMOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]

Drug(s) Affected By Keratin, type II cytoskeletal 78 (KRT78)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[41]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[232]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[375]

Drug(s) Affected By Ankyrin repeat domain-containing protein 35 (ANKRD35)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[115]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[928]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[169]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[158]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[321]

Drug(s) Affected By Misshapen-like kinase 1 (MINK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[178]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[318]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[54]

Drug(s) Affected By Proprotein convertase subtilisin/kexin type 9 (PCSK9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[149]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[141]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[929]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[143]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[930]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[190]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]

Drug(s) Affected By sn-1-specific diacylglycerol lipase ABHD11 (ABHD11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[184]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[329]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[385]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[184]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[194]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[184]

Drug(s) Affected By Transient receptor potential cation channel subfamily M member 4 (TRPM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[931]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
L-Glutamic Acid	DM4PUDW	Schizophrenia	6A20	Approved	[932]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[933]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[330]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[931]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[169]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]

Drug(s) Affected By Chromodomain-helicase-DNA-binding protein 5 (CHD5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[115]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[374]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[934]

Drug(s) Affected By m-AAA protease-interacting protein 1, mitochondrial (MAIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[395]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[194]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[375]

Drug(s) Affected By Reticulon-4-interacting protein 1, mitochondrial (RTN4IP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[158]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[171]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[177]

Drug(s) Affected By Beta-catenin-like protein 1 (CTNNBL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[225]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[70]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[372]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[26]

Drug(s) Affected By ATP-dependent RNA helicase DDX1 (DDX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[67]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[7]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[302]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[841]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[375]

Drug(s) Affected By Protein FAM3C (FAM3C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[9]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[10]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[9]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[324]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[158]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[385]

Drug(s) Affected By Heat shock protein 105 kDa (HSPH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[266]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[166]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[187]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[123]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[109]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[365]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]

Drug(s) Affected By CCR4-NOT transcription complex subunit 9 (CNOT9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[343]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[169]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[156]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[158]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[326]

Drug(s) Affected By Nuclear pore complex protein Nup205 (NUP205)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[395]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[177]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[549]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[560]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[194]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[195]

Drug(s) Affected By Ras-like protein family member 10A (RASL10A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[244]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[299]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[147]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[147]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[225]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[180]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[194]

Drug(s) Affected By Envoplakin (EVPL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[196]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[935]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[936]

Drug(s) Affected By Hyaluronan synthase 2 (HAS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[105]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[801]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[276]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[937]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[322]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]

Drug(s) Affected By Hyaluronan synthase 1 (HAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[938]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[159]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[939]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[939]
GUAIACOL	DMN4E7T	N. A.	N. A.	Phase 3	[939]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[939]
Puerarin	DMJIMXH	Alcohol dependence	6C40.2	Phase 2	[939]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
Chlorogenic acid	DM2Y3P4	Discovery agent	N.A.	Investigative	[939]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[940]

Drug(s) Affected By DNA repair protein RAD50 (RAD50)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[615]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[266]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[119]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[907]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]

Drug(s) Affected By CUGBP Elav-like family member 1 (CELF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[191]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[156]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]

Drug(s) Affected By Peptidylprolyl isomerase domain and WD repeat-containing protein 1 (PPWD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]

Drug(s) Affected By m7GpppX diphosphatase (DCPS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Bortezomib	DMNO38U	Leukemia		Approved	[178]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[156]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]

Drug(s) Affected By Mdm2-binding protein (MTBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[276]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[395]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[579]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[302]

Drug(s) Affected By N-terminal kinase-like protein (SCYL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[319]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[394]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[26]

Drug(s) Affected By NACHT, LRR and PYD domains-containing protein 3 (NLRP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[16]
Selenium	DM25CGV	N. A.	N. A.	Approved	[22]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[902]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[406]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[941]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[547]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[942]
Atropine	DMEN6X7	Organophosphate poisoning	NE6Z	Approved	[943]

Drug(s) Affected By Importin-9 (IPO9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[557]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[169]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[395]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[169]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[177]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[812]

Drug(s) Affected By Cell division cycle 5-like protein (CDC5L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[187]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[187]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[944]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[945]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[302]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[195]

Drug(s) Affected By Tetratricopeptide repeat protein 1 (TTC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[195]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[195]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[292]

Drug(s) Affected By Galactosylceramide sulfotransferase (GAL3ST1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[176]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[887]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[7]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[569]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[225]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[159]

Drug(s) Affected By Zinc phosphodiesterase ELAC protein 2 (ELAC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[169]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[156]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[946]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[302]

Drug(s) Affected By ATPase family gene 2 protein homolog B (AFG2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[396]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[156]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[115]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[302]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]

Drug(s) Affected By Kinesin-like protein KIFC1 (KIFC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[396]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[138]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[851]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]

Drug(s) Affected By Acetyl-CoA acetyltransferase, cytosolic (ACAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[10]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[244]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[191]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[947]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[143]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[344]

Drug(s) Affected By Chitinase domain-containing protein 1 (CHID1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[326]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[948]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[156]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[326]

Drug(s) Affected By ATP-dependent DNA/RNA helicase DHX36 (DHX36)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[158]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[195]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[195]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[26]

Drug(s) Affected By HEAT repeat-containing protein 1 (HEATR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[7]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[184]

Drug(s) Affected By Dedicator of cytokinesis protein 5 (DOCK5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[39]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[124]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[341]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[190]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[156]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]

Drug(s) Affected By MOB kinase activator 1A (MOB1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[187]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[187]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[318]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[395]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[158]

Drug(s) Affected By Conserved oligomeric Golgi complex subunit 4 (COG4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[177]
ACYLINE	DM9GRTK	Prostate cancer	2C82.0	Phase 2	[949]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[195]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[870]

Drug(s) Affected By Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[10]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[324]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[356]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[950]

Drug(s) Affected By Triggering receptor expressed on myeloid cells 1 (TREM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[196]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[612]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[569]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[633]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[951]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[232]
Nickel chloride	DMI12Y8	Discovery agent	N.A.	Investigative	[839]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[952]

Drug(s) Affected By CTP synthase 2 (CTPS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[326]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[558]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[170]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[170]

Drug(s) Affected By Sister chromatid cohesion protein PDS5 homolog B (PDS5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[142]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[219]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[354]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[302]

Drug(s) Affected By Obg-like ATPase 1 (OLA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[953]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[164]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[909]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]

Drug(s) Affected By Exocyst complex component 1 (EXOC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[395]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[195]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[326]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[375]

Drug(s) Affected By ATP-dependent RNA helicase DDX18 (DDX18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[126]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[168]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[330]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[115]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[168]

Drug(s) Affected By C-type lectin domain family 5 member A (CLEC5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
ANW-32821	DMMJOZD	N. A.	N. A.	Phase 2	[954]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[392]
Nickel chloride	DMI12Y8	Discovery agent	N.A.	Investigative	[839]

Drug(s) Affected By Probable ATP-dependent RNA helicase DDX56 (DDX56)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[326]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[146]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[177]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[302]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[194]

Drug(s) Affected By Cyclin-dependent kinase 12 (CDK12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[225]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[169]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[955]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[177]

Drug(s) Affected By Programmed cell death 1 ligand 1 (CD274)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[956]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[957]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[330]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[822]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[124]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[958]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]

Drug(s) Affected By DNA (DNMT3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[762]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[959]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[242]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[169]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[960]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[317]

Drug(s) Affected By Protein CLN8 (CLN8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[326]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[132]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[12]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[191]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[132]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[156]

Drug(s) Affected By DnaJ homolog subfamily B member 4 (DNAJB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[85]
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[266]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[166]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[187]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[11]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[475]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[109]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[85]

Drug(s) Affected By Protein NDRG3 (NDRG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Bortezomib	DMNO38U	Leukemia		Approved	[178]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[158]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]

Drug(s) Affected By Serpin B13 (SERPINB13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[124]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[326]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[375]

Drug(s) Affected By N-acetyl-D-glucosamine kinase (NAGK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[395]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[70]

Drug(s) Affected By tRNA (TRMT6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[115]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[177]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[25]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[194]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[392]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[375]

Drug(s) Affected By CASP8-associated protein 2 (CASP8AP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[189]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[335]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[395]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[961]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[962]

Drug(s) Affected By Protein-arginine deiminase type-4 (PADI4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[963]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[115]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[964]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[634]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[965]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[966]

Drug(s) Affected By Phenylalanine--tRNA ligase alpha subunit (FARSA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[164]
Bortezomib	DMNO38U	Leukemia		Approved	[178]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[193]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]

Drug(s) Affected By Exocyst complex component 6B (EXOC6B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[321]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[335]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[395]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[159]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[579]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[812]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[194]

Drug(s) Affected By Probable ATP-dependent RNA helicase DDX52 (DDX52)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[156]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[177]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[302]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[967]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[375]

Drug(s) Affected By Large ribosomal subunit protein eL36 (RPL36)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[156]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[114]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[184]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[968]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[301]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[160]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[194]

Drug(s) Affected By FACT complex subunit SPT16 (SUPT16H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[8]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[158]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[302]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[8]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[141]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[195]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[26]

Drug(s) Affected By Mitochondrial import inner membrane translocase subunit Tim10 B (TIMM10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[111]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[356]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[157]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[177]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[592]
Nickel chloride	DMI12Y8	Discovery agent	N.A.	Investigative	[969]

Drug(s) Affected By Heme-binding protein 2 (HEBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[970]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[191]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[356]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[159]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[354]

Drug(s) Affected By Glutathione S-transferase A1 (GSTA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[971]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[972]
Thiotepa	DMIZKOP	Breast cancer	2C60-2C65	Approved	[973]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[974]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[975]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[976]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[977]
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[978]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[7]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[30]

Drug(s) Affected By Glutathione S-transferase Mu 2 (GSTM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[979]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[980]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[981]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[156]

Drug(s) Affected By ATP-binding cassette sub-family C member 2 (ABCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lopinavir	DMITQS0	Human immunodeficiency virus infection	1C62	Approved	[982]
Sulfinpyrazone	DMEV954	Gout	FA25	Approved	[983]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[984]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[985]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[793]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[986]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[987]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[988]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[989]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[237]

Drug(s) Affected By Glutathione S-transferase Mu 3 (GSTM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[266]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[72]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[112]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[990]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[155]

Drug(s) Affected By Glutathione S-transferase Mu 4 (GSTM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[69]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Bortezomib	DMNO38U	Leukemia		Approved	[178]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[980]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[156]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[158]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[991]

Drug(s) Affected By Maleylacetoacetate isomerase (GSTZ1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[69]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[400]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[10]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[11]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[118]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[992]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[135]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[83]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[190]

Drug(s) Affected By Glutathione S-transferase Mu 1 (GSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[661]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[993]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[385]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[994]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[9]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[9]
Methyldopa	DM5I621	Hypertension	BA00-BA04	Approved	[995]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]

Drug(s) Affected By Glutathione S-transferase A2 (GSTA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[996]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[997]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[218]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[146]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[998]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[113]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[7]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[999]
Mefenamic acid	DMK7HFI	Dysmenorrhea	GA34.3	Approved	[1000]

Molecular Interaction Atlas of This Drug

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Lipocalin-type prostaglandin-D synthase (PTGDS)	DER3H9C	PTGDS_HUMAN	Substrate	[2]
Prostaglandin E synthase 2 (PTGES2)	DE3OALH	PGES2_HUMAN	Substrate	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
26S proteasome non-ATPase regulatory subunit 11 (PSMD11)	OT8KO67V	PSD11_HUMAN	Protein Interaction/Cellular Processes	[4]
26S proteasome non-ATPase regulatory subunit 5 (PSMD5)	OTYLM6S2	PSMD5_HUMAN	Protein Interaction/Cellular Processes	[4]
26S proteasome non-ATPase regulatory subunit 6 (PSMD6)	OTX59EGK	PSMD6_HUMAN	Protein Interaction/Cellular Processes	[4]
26S proteasome regulatory subunit 8 (PSMC5)	OTJOORMR	PRS8_HUMAN	Protein Interaction/Cellular Processes	[4]
3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B)	OTOA8WU2	PDE4B_HUMAN	Gene/Protein Processing	[5]
3',5'-cyclic-AMP phosphodiesterase 4D (PDE4D)	OT1RWFV0	PDE4D_HUMAN	Gene/Protein Processing	[5]
5'-nucleotidase domain-containing protein 1 (NT5DC1)	OTNI9MFH	NT5D1_HUMAN	Protein Interaction/Cellular Processes	[4]
6-phosphogluconate dehydrogenase, decarboxylating (PGD)	OTVG296F	6PGD_HUMAN	Gene/Protein Processing	[6]
60 kDa heat shock protein, mitochondrial (HSPD1)	OTTO1Y11	CH60_HUMAN	Protein Interaction/Cellular Processes	[4]
A-kinase anchor protein 13 (AKAP13)	OTOZAR14	AKP13_HUMAN	Protein Interaction/Cellular Processes	[4]

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