Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMDGPY9)

• Drug Name: LINOLEIC ACID Drug Info
• Synonyms: linoleic acid; 60-33-3; Linolic acid; Telfairic acid; (9Z,12Z)-octadeca-9,12-dienoic acid; cis,cis-Linoleic acid; Grape seed oil; Linoleate; cis,cis-9,12-Octadecadienoic acid; Emersol 315; cis-9,cis-12-Octadecadienoic acid; 9,12-Linoleic acid; Unifac 6550; 9Z,12Z-Linoleic acid; Extra Linoleic 90; 9-cis,12-cis-Linoleic acid; Polylin 515; Emersol 310; Polylin No. 515; Oils, grape; 9Z,12Z-octadecadienoic acid; alpha-Linoleic acid; all-cis-9,12-Octadecadienoic acid; Linoleic; acide linoleique; (Z,Z)-9,12-Octadecadienoic acid; acido lino

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 5280450
  ChEBI ID: CHEBI:17351
  CAS Number: CAS 60-33-3
  TTD Drug ID: DMDGPY9
  INTEDE Drug ID: DR2161

Molecule-Related Drug Atlas

Drug(s) Targeting Fatty acid-binding protein 4 (FABP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID27109571-Compound-27	DMXRTH4	N. A.	N. A.	Patented	[14]
PMID27109571-Compound-31	DMU690T	N. A.	N. A.	Patented	[14]
PMID27109571-Compound-16	DMZI25U	N. A.	N. A.	Patented	[14]
PMID27109571-Compound-14	DMVY6B9	N. A.	N. A.	Patented	[14]
PMID27109571-Compound-25	DM435GR	N. A.	N. A.	Patented	[14]
PMID27109571-Compound-30	DM24FSP	N. A.	N. A.	Patented	[14]
PMID27109571-Compound-29	DMDMEHQ	N. A.	N. A.	Patented	[14]
PMID27109571-Compound-18	DM4S5ME	N. A.	N. A.	Patented	[14]
PMID27109571-Compound-28	DMTZVY3	N. A.	N. A.	Patented	[14]
PMID27109571-Compound-20	DMQU9XP	N. A.	N. A.	Patented	[14]

Drug(s) Affected By Catalase (CAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[15]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[16]
Haloperidol	DM96SE0	Delirium		Approved	[17]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[18]
Selenium	DM25CGV	N. A.	N. A.	Approved	[19]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[20]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[21]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[23]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[25]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[27]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[30]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[33]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[34]

Drug(s) Affected By Peroxisome proliferator-activated receptor alpha (PPARA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[36]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[33]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[37]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[38]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]

Drug(s) Affected By Serum paraoxonase/arylesterase 1 (PON1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[42]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[43]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[44]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[45]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[46]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[47]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[48]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[49]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[50]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[42]

Drug(s) Affected By Endothelin-1 (EDN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[55]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[58]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[59]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[60]

Drug(s) Affected By Nitric oxide synthase 3 (NOS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[62]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[17]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[64]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[65]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[66]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[67]
Fructose	DM43AN2	Vomiting	MD90	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]

Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[70]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[70]
Etoricoxib	DM6A4NW	Rheumatoid arthritis	FA20	Approved	[70]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[71]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[72]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[73]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[74]
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[75]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[76]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[17]

Drug(s) Affected By Cytochrome P450 2E1 (CYP2E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fomepizole	DM6VOWQ	Athylene glycol or methanol poisoning	NE61	Approved	[77]
Ademetionine	DMYQDBO	Hepatic fibrosis	DB93.0	Approved	[78]
Theophylline	DMRJFN9	Bronchitis	CA20	Approved	[17]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[79]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[80]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[81]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Didanosine	DMI2QPE	Human immunodeficiency virus infection	1C62	Approved	[17]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[84]

Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[85]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[86]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[87]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[88]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[89]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[90]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[91]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[92]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[93]

Drug(s) Affected By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[86]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[94]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[89]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[88]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[71]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[95]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[89]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[12]
Fluconazole	DMOWZ6B	Cryptococcal meningitis		Approved	[88]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[89]

Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[86]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[84]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[88]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[96]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[71]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[89]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[73]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[89]
Desipramine	DMT2FDC	Attention deficit hyperactivity disorder	6A05.Z	Approved	[84]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[17]

Drug(s) Affected By Stearoyl-CoA desaturase (SCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[97]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[98]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[98]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[99]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[98]
Fructose	DM43AN2	Vomiting	MD90	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[98]

Drug(s) Affected By Acyl-CoA 6-desaturase (FADS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[101]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[104]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[107]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[108]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[109]
Bortezomib	DMNO38U	Leukemia		Approved	[110]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[111]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[112]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[113]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[114]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[115]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[116]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[117]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[118]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[119]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[111]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[120]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[114]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[122]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[116]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Selenium	DM25CGV	N. A.	N. A.	Approved	[124]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[125]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[126]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[127]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[128]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[129]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[15]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[130]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[131]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[132]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[133]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[134]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[99]

Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[129]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[135]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[97]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[136]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[105]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[137]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[138]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[139]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[140]

Drug(s) Affected By Cholinesterase (BCHE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[141]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[142]
Galantamine	DMEO794	Alzheimer disease	8A20	Approved	[143]
Rivastigmine	DMG629M	Alzheimer disease	8A20	Approved	[144]
Donepezil	DMIYG7Z	Advanced cancer	2A00-2F9Z	Approved	[17]
Succinylcholine	DM2ET1M	Plasma cell myeloma	2A83.1	Approved	[145]
Ethopropazine	DM0N3L7	Parkinson disease	8A00.0	Approved	[142]
Dimenhydrinate	DM264B3	Meniere disease	AB31.0	Approved	[146]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[147]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[146]

Drug(s) Affected By Glutathione S-transferase A1 (GSTA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[148]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[149]
Thiotepa	DMIZKOP	Breast cancer	2C60-2C65	Approved	[150]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[151]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[153]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[154]
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[155]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[156]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[64]

Drug(s) Affected By Cytochrome P450 2A6 (CYP2A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tegafur	DM31ZQM	Solid tumour/cancer	2A00-2F9Z	Approved	[157]
Methoxsalen	DME8FZ9	Cutaneous T-cell lymphoma	2B01	Approved	[158]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[159]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[160]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[81]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[161]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[162]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[163]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[164]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[165]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[166]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[122]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[167]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[15]
Selenium	DM25CGV	N. A.	N. A.	Approved	[168]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[169]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[132]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[133]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[170]

Drug(s) Affected By Phospholipid-transporting ATPase ABCA1 (ABCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[171]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[172]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[101]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[173]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[174]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[175]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[177]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[178]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[179]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[180]
Fructose	DM43AN2	Vomiting	MD90	Approved	[17]
Ketoprofen	DMRKXPT	Bursitis		Approved	[17]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[181]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[182]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[183]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[184]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[185]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[117]

Drug(s) Affected By Interferon gamma (IFNG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[186]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[187]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[188]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[189]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[190]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[192]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[193]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[194]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[195]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[116]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[196]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[197]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[15]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[197]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[118]
Selenium	DM25CGV	N. A.	N. A.	Approved	[198]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[199]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[200]

Drug(s) Affected By Interleukin-4 (IL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[201]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[202]
Tolnaftate	DM28MU7	Dermatophytosis	1F28.2	Approved	[203]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[204]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[205]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[206]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[189]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[190]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[207]

Drug(s) Affected By Interleukin-5 (IL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[187]
Tolnaftate	DM28MU7	Dermatophytosis	1F28.2	Approved	[203]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[204]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[208]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[209]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[210]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[211]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[212]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[213]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[214]

Drug(s) Affected By Fatty acid-binding protein, heart (FABP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[101]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[215]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[48]
Haloperidol	DM96SE0	Delirium		Approved	[216]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[127]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[216]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[217]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[218]

Drug(s) Affected By Fatty acid-binding protein, liver (FABP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[219]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[156]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[220]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[219]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[219]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[219]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[221]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[222]

Drug(s) Affected By Choriogonadotropin subunit beta 3 (CGB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[57]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[223]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[224]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[225]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[226]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[225]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[227]
Bezafibrate	DMZDCS0	Hypercholesterolaemia	5C80.0	Approved	[6]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[228]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[115]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[229]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[230]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[117]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[202]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[231]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[125]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[232]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[233]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[234]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[229]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[184]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[117]
Selenium	DM25CGV	N. A.	N. A.	Approved	[235]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[236]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[237]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[238]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[239]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[240]

Drug(s) Affected By Retinoic acid receptor RXR-alpha (RXRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[241]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[156]
Selenium	DM25CGV	N. A.	N. A.	Approved	[242]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[173]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[243]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[244]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[245]
Acitretin	DM8BKU9	Psoriasis vulgaris	EA90	Approved	[246]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[127]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[247]

Drug(s) Affected By Interleukin-10 (IL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[248]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[187]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[204]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[249]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[250]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[251]
Bisoprolol	DM3UZ95	Hypertension	BA00-BA04	Approved	[252]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[192]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[253]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[254]

Drug(s) Affected By ATP-binding cassette sub-family G member 1 (ABCG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[172]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[173]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[29]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[255]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[256]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[127]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[127]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[257]

Drug(s) Affected By Type I iodothyronine deiodinase (DIO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[258]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[259]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[260]
Ergocalciferol	DMHO0AR	Hypoparathyroidism	5A50	Approved	[261]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[262]
Masoprocol	DMMVNZ0	Prostate cancer	2C82.0	Approved	[261]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[263]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[264]

Drug(s) Affected By Thyroxine 5-deiodinase (DIO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[265]
Vemurafenib	DM62UG5	Melanoma	2C30	Approved	[266]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[231]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Ergocalciferol	DMHO0AR	Hypoparathyroidism	5A50	Approved	[261]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[265]
Masoprocol	DMMVNZ0	Prostate cancer	2C82.0	Approved	[261]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[265]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[267]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[265]

Drug(s) Affected By Interleukin-2 (IL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sirolimus	DMGW1ID	Advanced cancer	2A00-2F9Z	Approved	[17]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[202]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[204]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[268]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[269]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[270]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[210]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[212]
Fentanyl	DM8WAHT	Analgesia	MB40.8	Approved	[271]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[272]

Drug(s) Affected By Peroxisome proliferator-activated receptor delta (PPARD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[129]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[273]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[22]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[274]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[275]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[276]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[277]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[163]

Drug(s) Affected By Solute carrier family 22 member 6 (SLC22A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[278]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[279]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[279]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[280]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[279]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[279]
Succinic acid	DMDWICP	Malnutrition	5B50-5B71	Approved	[281]
Mefenamic acid	DMK7HFI	Dysmenorrhea	GA34.3	Approved	[279]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[282]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[279]

Drug(s) Affected By Organic anion transporter 3 (SLC22A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[283]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[278]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[284]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[285]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[286]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[286]
Cefdinir	DMJ7A0H	Bacterial infection	1A00-1C4Z	Approved	[287]
Cefaclor	DMJXDGC	Bacterial infection	1A00-1C4Z	Approved	[287]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[288]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[289]

Drug(s) Affected By Type II iodothyronine deiodinase (DIO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[113]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[290]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[291]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[262]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[111]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[292]
Ergocalciferol	DMHO0AR	Hypoparathyroidism	5A50	Approved	[261]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[108]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[293]

Drug(s) Affected By Hepatitis A virus cellular receptor 1 (HAVCR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[156]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[294]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[295]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[296]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[297]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[298]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[299]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[156]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[300]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[301]

Drug(s) Affected By Achaete-scute homolog 2 (ASCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[302]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[303]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[304]
Bezafibrate	DMZDCS0	Hypercholesterolaemia	5C80.0	Approved	[6]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[305]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[306]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[307]
Fructose	DM43AN2	Vomiting	MD90	Approved	[100]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[308]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[309]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[310]
Ketotifen	DM74XKS	Allergic conjunctivitis	9A60.02	Approved	[311]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[312]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[313]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[312]

Drug(s) Affected By Polyunsaturated fatty acid lipoxygenase ALOX15 (ALOX15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[314]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[315]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[316]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[83]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[301]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[317]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[318]
3,4-Dihydroxycinnamic Acid	DMVZL26	Thrombocytopenia	3B64	Phase 4	[319]
EXISULIND	DMBY56U	Colorectal cancer	2B91.Z	Phase 3	[320]
BAICALEIN	DM4C7E6	Influenza virus infection	1E30-1E32	Phase 2	[321]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Fatty acid-binding protein 4 (FABP4)	TTHWMFZ	FABP4_HUMAN	Inhibitor	[2]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Linoleate 10-hydratase (10-LAH)	DEWD860	A0A1I9RYU9_LACPN	Substrate	[3]
Linoleate isomerase (lai)	DEQ58KF	D2BQ64_LACLK	Substrate	[4] , [5]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Achaete-scute homolog 2 (ASCL2)	OT3D62WB	ASCL2_HUMAN	Gene/Protein Processing	[6]
Acyl-CoA 6-desaturase (FADS2)	OTUX531P	FADS2_HUMAN	Gene/Protein Processing	[7]
ATP-binding cassette sub-family G member 1 (ABCG1)	OT5BG6MK	ABCG1_HUMAN	Gene/Protein Processing	[8]
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Gene/Protein Processing	[9]
Catalase (CAT)	OTHEBX9R	CATA_HUMAN	Gene/Protein Processing	[10]
Cholinesterase (BCHE)	OTOH3WQ9	CHLE_HUMAN	Gene/Protein Processing	[11]
Choriogonadotropin subunit beta 3 (CGB3)	OTVM2SU3	CGB3_HUMAN	Protein Interaction/Cellular Processes	[6]
Cytochrome P450 1A2 (CYP1A2)	OTLLBX48	CP1A2_HUMAN	Gene/Protein Processing	[12]
Cytochrome P450 2A6 (CYP2A6)	OT52TWG3	CP2A6_HUMAN	Gene/Protein Processing	[13]
Cytochrome P450 2C19 (CYP2C19)	OTFMJYYE	CP2CJ_HUMAN	Gene/Protein Processing	[12]

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