Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNFADH)

• Drug Name: APR-246 Drug Info
• Synonyms: Eprenetapopt

Indication

Disease Entry	ICD 11	Status	REF
Ovarian cancer	2C73	Phase 2	[1]
Bladder cancer	2C94	Phase 1/2	[2]
Gastric adenocarcinoma	2B72	Phase 1/2	[2]
Esophageal cancer	2B70	Phase 1	[1]
Myelodysplastic syndrome	2A37	Phase 1	[1]
Solid tumour/cancer	2A00-2F9Z	Preclinical	[3]

• Cross-matching ID:
  PubChem CID: 52918385
  CAS Number: CAS 5291-32-7
  TTD Drug ID: DMNFADH

Molecule-Related Drug Atlas

Drug(s) Targeting Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Contusugene ladenovec	DMN9ETB	Oral cancer	2B6E	Phase 3	[6]
QPI-1002	DMDU5Y2	Renal transplantation	NE84	Phase 3	[7]
Thymoquinone	DMVDTR2	Polycystic ovarian syndrome	5A80.1	Phase 2/3	[8]
APG-115	DMIFA0L	Prolymphocytic leukaemia	2A82.1	Phase 2	[1]
SGT-53	DMLYIPA	Pancreatic cancer	2C10	Phase 2	[9]
Ad-p53	DMJSWXL	Solid tumour/cancer	2A00-2F9Z	Phase 2	[10]
Kevetrin	DMFO6MH	Ovarian cancer	2C73	Phase 2	[1]
INGN-225	DMF7J6D	Head and neck cancer	2D42	Phase 2	[11]
ALT-801	DM9KL7P	Acute myeloid leukaemia	2A60	Phase 2	[12]
ISA-P53-01	DMQ5EYJ	Colorectal cancer	2B91.Z	Phase 1/2	[13]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[14]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[15]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[16]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[17]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[18]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[19]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[20]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[21]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[22]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[23]

Drug(s) Affected By RAB7A-interacting MON1-CCZ1 complex subunit 1 (RIMOC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[25]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[30]

Drug(s) Affected By Uncharacterized membrane protein C3orf80 (C3ORF80)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[33]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[34]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[35]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]

Drug(s) Affected By Splicing regulator ARVCF (ARVCF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[36]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[39]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[40]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[41]
Hexadecanoic acid	DMWUXDZ	Discovery agent	N.A.	Investigative	[42]

Drug(s) Affected By DNA fragmentation factor subunit alpha (DFFA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[25]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[46]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[47]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[48]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[26]

Drug(s) Affected By F-BAR domain only protein 1 (FCHO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[49]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[50]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[30]

Drug(s) Affected By Chromodomain-helicase-DNA-binding protein 2 (CHD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[51]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[52]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[25]
Bortezomib	DMNO38U	Leukemia		Approved	[48]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[55]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[56]

Drug(s) Affected By Transcription factor MafG (MAFG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[57]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[58]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[60]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[53]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]

Drug(s) Affected By U4/U6 small nuclear ribonucleoprotein Prp4 (PRPF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[25]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[63]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[64]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[40]
PP-242	DM2348V	Discovery agent	N.A.	Investigative	[65]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[63]
Arachidonic Acid	DMUOQZD	Discovery agent	N.A.	Investigative	[66]

Drug(s) Affected By Eukaryotic translation initiation factor 1b (EIF1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[72]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[41]

Drug(s) Affected By Frizzled-7 (FZD7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[76]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[77]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[78]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[79]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[80]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[81]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[82]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[83]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[85]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[86]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[87]

Drug(s) Affected By Leucine-rich repeat and calponin homology domain-containing protein 4 (LRCH4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[88]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[89]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[90]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[91]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[92]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[41]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[41]

Drug(s) Affected By E3 SUMO-protein ligase PIAS2 (PIAS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[26]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[64]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[40]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[93]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[94]

Drug(s) Affected By Transmembrane and coiled-coil domains protein 1 (TMCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[99]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[54]

Drug(s) Affected By Ferritin light chain (FTL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[57]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[58]
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[102]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[25]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[103]

Drug(s) Affected By F-box/SPRY domain-containing protein 1 (FBXO45)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[105]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[99]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[33]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[40]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[30]

Drug(s) Affected By Platelet glycoprotein Ib beta chain (GP1BB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[49]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[70]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[107]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[108]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[91]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[109]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[110]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[112]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[113]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[115]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[116]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[117]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[118]

Drug(s) Affected By Transcription factor E3 (TFE3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[52]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[61]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[61]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[26]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[119]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]

Drug(s) Affected By DnaJ homolog subfamily B member 2 (DNAJB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[106]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[120]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[61]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[122]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]

Drug(s) Affected By Microtubule-associated protein 4 (MAP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[106]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[76]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[25]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[125]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[126]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[127]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[128]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[129]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[130]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[131]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[132]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[133]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[134]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[135]

Drug(s) Affected By HLA class I histocompatibility antigen, alpha chain F (HLA-F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[136]
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[136]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[138]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Repaglinide	DM5SXUV	Diabetic complication	5A2Y	Approved	[136]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[140]
Saquinavir	DMG814N	Human immunodeficiency virus infection	1C62	Approved	[136]

Drug(s) Affected By High affinity cationic amino acid transporter 1 (SLC7A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[141]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[142]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[102]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[61]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[53]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]

Drug(s) Affected By ER lumen protein-retaining receptor 2 (KDELR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[140]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[25]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[144]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[26]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[145]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[146]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[147]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[148]

Drug(s) Affected By Myosin-9 (MYH9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[149]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[85]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[25]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[151]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]

Drug(s) Affected By Amiloride-sensitive sodium channel subunit alpha (SCNN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[153]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[76]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[154]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[155]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[53]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]

Drug(s) Affected By Interleukin-15 (IL15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[102]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[158]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[160]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[161]
Bortezomib	DMNO38U	Leukemia		Approved	[48]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[162]

Drug(s) Affected By Eukaryotic translation initiation factor 1 (EIF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[163]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[164]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[61]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[165]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[25]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[166]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[167]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[168]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[18]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[169]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[170]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[171]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[172]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[173]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[174]

Drug(s) Affected By Neutral amino acid transporter A (SLC1A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[175]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[142]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[61]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[61]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[142]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[176]

Drug(s) Affected By Translocon-associated protein subunit alpha (SSR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[177]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[178]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[25]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[26]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[179]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[180]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]

Drug(s) Affected By Ran GTPase-activating protein 1 (RANGAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[25]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[182]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[63]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]

Drug(s) Affected By Protein PRRC2A (PRRC2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[36]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[86]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[25]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[179]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[89]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[183]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[184]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[185]

Drug(s) Affected By LIM domain kinase 2 (LIMK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[186]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[187]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[188]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[179]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[189]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]

Drug(s) Affected By Smoothelin (SMTN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[190]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[26]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[191]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[192]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]

Drug(s) Affected By UV excision repair protein RAD23 homolog A (RAD23A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[193]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[194]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[25]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[26]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[195]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[196]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[56]

Drug(s) Affected By UV excision repair protein RAD23 homolog B (RAD23B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[25]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[46]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[197]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[195]
Indomethacin	DMSC4A7	Bursitis		Approved	[198]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[74]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[199]

Drug(s) Affected By Eukaryotic translation initiation factor 5 (EIF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[200]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[102]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[181]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[201]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[25]

Drug(s) Affected By Period circadian protein homolog 3 (PER3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[80]
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[99]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[192]

Drug(s) Affected By Sestrin-2 (SESN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[203]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[204]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[106]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[206]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[142]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[206]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[207]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[203]

Drug(s) Affected By AP-3 complex subunit sigma-2 (AP3S2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[67]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]

Drug(s) Affected By CD81 antigen (CD81)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[133]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[36]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[15]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[25]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[208]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[26]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]

Drug(s) Affected By Signal peptidase complex subunit 3 (SPCS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[25]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[179]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[147]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[210]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[211]
Forskolin	DM6ITNG	Solid tumour/cancer	2A00-2F9Z	Investigative	[212]

Drug(s) Affected By DDB1- and CUL4-associated factor 7 (DCAF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[213]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[25]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[89]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[56]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[56]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]

Drug(s) Affected By Disks large homolog 4 (DLG4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[25]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[49]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[214]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[33]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[56]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[215]

Drug(s) Affected By Small ribosomal subunit protein uS10m (MRPS10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[216]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[146]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[189]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[36]

Drug(s) Affected By Heat shock factor protein 1 (HSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[217]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[218]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[218]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[219]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[220]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[218]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[218]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[218]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[218]

Drug(s) Affected By Large neutral amino acids transporter small subunit 1 (SLC7A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[221]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[222]
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[175]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[76]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[223]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[221]

Drug(s) Affected By Protein Dr1 (DR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Haloperidol	DM96SE0	Delirium		Approved	[125]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[125]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[224]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]

Drug(s) Affected By Transducin-like enhancer protein 4 (TLE4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[76]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[96]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[49]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[26]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[225]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[179]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[90]

Drug(s) Affected By Cytoskeleton-associated protein 4 (CKAP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[226]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[227]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[146]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[25]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[125]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[26]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[89]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[99]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[229]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[174]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[80]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[230]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[231]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[232]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[233]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[222]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[234]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[235]

Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[134]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[231]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[236]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[237]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[238]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[239]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[240]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[231]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[241]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[242]

Drug(s) Affected By Golgin subfamily A member 2 (GOLGA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[102]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[186]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[25]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[243]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[49]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[244]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[91]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[147]

Drug(s) Affected By AP-1 complex subunit beta-1 (AP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[213]
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[25]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[245]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[89]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[72]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[246]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]

Drug(s) Affected By HMG domain-containing protein 3 (HMGXB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[89]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[147]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[64]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[36]
geraniol	DMS3CBD	Discovery agent	N.A.	Investigative	[247]

Drug(s) Affected By Glutamate receptor ionotropic, NMDA 2A (GRIN2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[213]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[248]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[249]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[250]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[76]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]

Drug(s) Affected By Forkhead box protein C1 (FOXC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[221]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[76]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[221]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[87]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]

Drug(s) Affected By Calcium/calmodulin-dependent protein kinase type II subunit delta (CAMK2D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[83]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[178]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[160]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[25]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[96]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[180]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[146]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[35]

Drug(s) Affected By Protein patched homolog 1 (PTCH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[252]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Vismodegib	DM5IXKQ	Basal cell carcinoma	2C32	Approved	[253]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[254]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[86]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[255]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[256]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[257]

Drug(s) Affected By Trophoblast glycoprotein (TPBG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[106]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[87]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[25]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[26]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]

Drug(s) Affected By Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[203]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[82]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[258]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[114]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[259]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[260]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[240]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[261]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[142]

Drug(s) Affected By HUWE1-associated protein modifying stress responses 1 (HAPSTR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[26]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[99]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[64]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[262]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[263]

Drug(s) Affected By Astrocytic phosphoprotein PEA-15 (PEA15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[25]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[179]

Drug(s) Affected By Serine/threonine-protein kinase STK11 (STK11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[264]
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[265]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[266]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[267]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[89]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[268]
GDC-0980/RG7422	DMF3MV1	Non-hodgkin lymphoma	2B33.5	Phase 2	[269]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[270]

Drug(s) Affected By Insulin-like growth factor-binding protein 7 (IGFBP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[271]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[139]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[272]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[25]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[243]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[176]

Drug(s) Affected By Sister chromatid cohesion protein PDS5 homolog A (PDS5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[25]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[99]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[183]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[273]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[40]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[41]

Drug(s) Affected By Sprouty-related, EVH1 domain-containing protein 3 (SPRED3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[90]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[40]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[274]

Drug(s) Affected By Protein FAM161A (FAM161A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[275]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[64]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[211]

Drug(s) Affected By Transmembrane protein 119 (TMEM119)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[178]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[146]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[26]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[35]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[276]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[277]

Drug(s) Affected By Sigma intracellular receptor 2 (TMEM97)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[106]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[102]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[278]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[178]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[96]

Drug(s) Affected By DnaJ homolog subfamily C member 21 (DNAJC21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[60]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[78]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[89]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[78]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[279]

Drug(s) Affected By Meckelin (TMEM67)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[280]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[54]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[40]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[281]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[282]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[160]

Drug(s) Affected By Spindlin-3 (SPIN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[56]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[54]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[40]

Drug(s) Affected By Ceramide-1-phosphate transfer protein (CPTP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[280]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[40]

Drug(s) Affected By Protein GPR107 (GPR107)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[283]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[67]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[209]

Drug(s) Affected By Cytosolic phospholipase A2 zeta (PLA2G4F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[36]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[96]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[35]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[30]

Drug(s) Affected By DENN domain-containing protein 5A (DENND5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[123]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[141]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[160]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[179]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[54]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]

Drug(s) Affected By Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (JMJD6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[25]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[145]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[89]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[147]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[109]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[64]

Drug(s) Affected By DENN domain-containing protein 1B (DENND1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[76]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[99]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[63]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[35]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[76]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[67]

Drug(s) Affected By RNA demethylase ALKBH5 (ALKBH5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[86]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[284]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[215]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[64]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[40]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[41]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[41]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[285]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[160]

Drug(s) Affected By Interleukin-34 (IL34)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[286]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[30]

Drug(s) Affected By Autophagy-related protein 9A (ATG9A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[25]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[245]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[287]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[41]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[41]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[288]

Drug(s) Affected By Cadherin-24 (CDH24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[146]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[89]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[280]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[40]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[30]

Drug(s) Affected By Centrosomal protein of 57 kDa (CEP57)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[289]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[186]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[48]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[79]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[179]

Drug(s) Affected By Purine nucleoside phosphorylase LACC1 (LACC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[76]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[33]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[290]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]

Drug(s) Affected By Sperm-associated antigen 16 protein (SPAG16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[280]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[72]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[291]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[71]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]

Drug(s) Affected By Protein shisa-5 (SHISA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[26]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[99]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[56]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[109]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[40]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[292]

Drug(s) Affected By Cytochrome P450 4X1 (CYP4X1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[293]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[243]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[294]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[90]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[54]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[291]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[146]

Drug(s) Affected By Refilin-B (RFLNB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[87]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[208]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[295]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[292]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]

Drug(s) Affected By Solute carrier family 66 member 3 (SLC66A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[26]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[179]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[39]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[35]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[56]

Drug(s) Affected By Procollagen galactosyltransferase 1 (COLGALT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[25]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[26]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[89]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[90]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[33]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[296]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[40]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[292]

Drug(s) Affected By Reticulophagy regulator 2 (RETREG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[74]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[90]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[40]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[41]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[41]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[292]

Drug(s) Affected By Hemicentin-2 (HMCN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Indomethacin	DMSC4A7	Bursitis		Approved	[198]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[297]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[34]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[35]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[296]

Drug(s) Affected By ATP-dependent RNA helicase DDX54 (DDX54)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[41]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[41]

Drug(s) Affected By Oxoeicosanoid receptor 1 (OXER1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[296]

Drug(s) Affected By Probable glutathione peroxidase 8 (GPX8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[298]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[155]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[25]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[26]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[299]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[34]

Drug(s) Affected By Ubiquitin carboxyl-terminal hydrolase BAP1 (BAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[44]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[52]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Olaparib	DM8QB1D	Ovarian cancer	2C73	Approved	[300]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[301]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[67]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[302]

Drug(s) Affected By Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (RUBCN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[90]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[146]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[76]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[40]

Drug(s) Affected By Protein TMEPAI (PMEPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[76]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[86]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[155]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[61]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[61]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[303]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[26]

Drug(s) Affected By Protein shisa-4 (SHISA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[87]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[87]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[49]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[40]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[30]

Drug(s) Affected By OTU domain-containing protein 5 (OTUD5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[41]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[41]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[304]

Drug(s) Affected By Protein N-terminal glutamine amidohydrolase (NTAQ1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[178]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[147]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[305]

Drug(s) Affected By RNA-binding protein 41 (RBM41)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[186]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[187]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[63]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[64]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[63]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[160]

Drug(s) Affected By Calponin-2 (CNN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[306]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[87]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[87]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[25]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[49]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[33]

Drug(s) Affected By Retinoic acid receptor responder protein 2 (RARRES2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[307]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[292]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[308]

Drug(s) Affected By A-kinase anchor protein 9 (AKAP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[177]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[309]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[160]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[74]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[310]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[99]

Drug(s) Affected By Nucleolar protein 10 (NOL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[146]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[224]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[99]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[33]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[64]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[40]

Drug(s) Affected By Tubulin-specific chaperone D (TBCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[25]
Bortezomib	DMNO38U	Leukemia		Approved	[48]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[89]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[276]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[36]

Drug(s) Affected By Deoxyhypusine hydroxylase (DOHH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[178]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[71]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[67]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[36]

Drug(s) Affected By Spindlin interactor and repressor of chromatin-binding protein (SPINDOC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[41]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[41]

Drug(s) Affected By Single-stranded DNA-binding protein 4 (SSBP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Fenretinide	DMRD5SP	Macular degeneration	9B78.3	Phase 3	[311]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[109]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[40]

Drug(s) Affected By Caspase recruitment domain-containing protein 10 (CARD10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[99]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[155]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[140]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[46]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[96]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[312]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[313]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF26 (RNF26)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[141]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[141]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[86]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[179]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]

Drug(s) Affected By Tripartite motif-containing protein 5 (TRIM5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[224]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[99]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[33]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[291]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[147]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[40]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[36]

Drug(s) Affected By Talin rod domain-containing protein 1 (TLNRD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[314]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[90]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[56]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[315]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[292]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[63]

Drug(s) Affected By A disintegrin and metalloproteinase with thrombospondin motifs 10 (ADAMTS10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[316]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[40]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[317]

Drug(s) Affected By Pleckstrin homology domain-containing family A member 4 (PLEKHA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[26]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[56]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[50]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[40]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[41]

Drug(s) Affected By Protein bicaudal C homolog 1 (BICC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[314]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[27]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[35]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[277]
Nitrobenzanthrone	DMN6L70	N. A.	N. A.	Investigative	[318]

Drug(s) Affected By Vasculin-like protein 1 (GPBP1L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[160]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[146]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[41]

Drug(s) Affected By RNA polymerase II subunit A C-terminal domain phosphatase SSU72 (SSU72)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[25]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[89]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[40]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[36]

Drug(s) Affected By Anillin (ANLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[106]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[87]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[190]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[319]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[25]

Drug(s) Affected By Midasin (MDN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[41]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[177]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[160]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[320]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[179]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[99]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]

Drug(s) Affected By Protein eva-1 homolog B (EVA1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[87]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[49]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[90]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[273]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]

Drug(s) Affected By Protein AATF (AATF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[321]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[25]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[322]
PF-3758309	DM36PKZ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[323]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[64]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[41]

Drug(s) Affected By Short coiled-coil protein (SCOC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[146]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[25]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[48]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[26]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[56]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]

Drug(s) Affected By F-box/LRR-repeat protein 4 (FBXL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[159]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[160]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[40]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[262]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[160]

Drug(s) Affected By Histone chaperone ASF1A (ASF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[25]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[26]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[324]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[324]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[82]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[145]

Drug(s) Affected By Nischarin (NISCH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[187]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[25]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[142]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[26]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[41]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[263]

Drug(s) Affected By Tudor and KH domain-containing protein (TDRKH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[76]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[25]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[73]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[316]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[29]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[40]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[41]

Drug(s) Affected By Malignant fibrous histiocytoma-amplified sequence 1 (MFHAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[214]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[89]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[33]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[56]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[35]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF115 (RNF115)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[177]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[178]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[26]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[224]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[97]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[39]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[177]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cellular tumor antigen p53 (TP53)	TT7SBF5	P53_HUMAN	Stimulator	[4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
14-3-3 protein gamma	OTYQTMPI	1433G_HUMAN	Gene/Protein Processing	[5]
A disintegrin and metalloproteinase with thrombospondin motifs 10 (ADAMTS10)	OTNJ9VSU	ATS10_HUMAN	Gene/Protein Processing	[5]
A-kinase anchor protein 9 (AKAP9)	OT7Z2YRP	AKAP9_HUMAN	Gene/Protein Processing	[5]
Amiloride-sensitive sodium channel subunit alpha (SCNN1A)	OTE2KVZV	SCNNA_HUMAN	Gene/Protein Processing	[5]
Anillin (ANLN)	OTXJY54C	ANLN_HUMAN	Gene/Protein Processing	[5]
AP-1 complex subunit beta-1 (AP1B1)	OTY0K84R	AP1B1_HUMAN	Gene/Protein Processing	[5]
AP-3 complex subunit sigma-2 (AP3S2)	OTN8P9OE	AP3S2_HUMAN	Gene/Protein Processing	[5]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[5]
Astrocytic phosphoprotein PEA-15 (PEA15)	OTKCKTSX	PEA15_HUMAN	Gene/Protein Processing	[5]
ATP-dependent RNA helicase DDX54 (DDX54)	OTVOJU6G	DDX54_HUMAN	Gene/Protein Processing	[5]

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