Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMR8O3X)

Drug Name
paraquat Drug Info
Synonyms 1,1'-dimethyl-4,4' bipyridinium dichloride
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
15939
ChEBI ID
CHEBI:34905
CAS Number
CAS 4685-14-7
TTD Drug ID
DMR8O3X
VARIDT Drug ID
DR00002

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTP
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Patented Agent(s)
Preclinical Drug(s)
Discontinued Drug(s)
Download the Complete Related Drug List
Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [11]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [12]
Methotrexate DM2TEOL Anterior urethra cancer Approved [3]
Folic Acid DMEMBJC Colorectal carcinoma Approved [13]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [3]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [3]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [14]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [3]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [15]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [16]
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Drug(s) Transported By Multidrug and toxin extrusion protein 1 (SLC47A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aciclovir DMYLOVR Genital herpes 1A94 Approved [17]
Metformin DM89QE1 Colorectal carcinoma Approved [18]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [17]
Cimetidine DMH61ZB Acid-reflux disorder DA22 Approved [17]
Chloroquine DMSI5CB Malaria 1F40-1F45 Approved [19]
Procainamide DMNMXR8 Ventricular arrhythmias BC71 Approved [17]
Topotecan DMP6G8T Central nervous system neoplasm Approved [17]
Cephalexin DMD5JU8 Acute otitis media AB00 Approved [20]
LY2835219 DM93VBZ Breast cancer 2C60-2C65 Approved [21]
Dofetilide DMPN1TW Sinus rhythm disorder BC9Y Approved [22]
Pyrimethamine DM5X7VY Malaria 1F40-1F45 Approved [23]
Cimetidine DMH61ZB Acid-reflux disorder DA22 Approved [24]
Verapamil DMA7PEW Angina pectoris BA40 Approved [25]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [24]
Methotrexate DM2TEOL Anterior urethra cancer Approved [26]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [27]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [30]
Quinidine DMLPICK N. A. N. A. Approved [24]
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Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [31]
Dicloxacillin DM8EU0Z Bacterial infection 1A00-1C4Z Approved [31]
Ergonovine DM0VEC1 Postpartum haemorrhage JA43 Approved [32]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [33]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [34]
Mizolastine DM1FDN8 Allergic rhinitis CA08.0 Approved [35]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [36]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [37]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [38]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [39]
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Drug(s) Affected By Cholinesterase (BCHE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [40]
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [41]
Galantamine DMEO794 Alzheimer disease 8A20 Approved [42]
Rivastigmine DMG629M Alzheimer disease 8A20 Approved [43]
Donepezil DMIYG7Z Advanced cancer 2A00-2F9Z Approved [32]
Succinylcholine DM2ET1M Plasma cell myeloma 2A83.1 Approved [44]
Ethopropazine DM0N3L7 Parkinson disease 8A00.0 Approved [41]
Dimenhydrinate DM264B3 Meniere disease AB31.0 Approved [45]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [46]
Chlorpheniramine DM5URA2 Allergic rhinitis CA08.0 Approved [45]
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Drug(s) Affected By Nitric oxide synthase, inducible (NOS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [47]
Indomethacin DMSC4A7 Bursitis Approved [48]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [49]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [50]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [52]
Quercetin DM3NC4M Obesity 5B81 Approved [53]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [54]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [55]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [56]
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Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [57]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [58]
Gamolenic acid DMQN30Z Allergy 4A80-4A85 Approved [59]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [60]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [61]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [62]
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [63]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [64]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [65]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [66]
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Drug(s) Affected By Interleukin-1 alpha (IL1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [65]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [65]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [68]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [65]
Methotrexate DM2TEOL Anterior urethra cancer Approved [26]
Quercetin DM3NC4M Obesity 5B81 Approved [69]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [65]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [54]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
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Drug(s) Affected By Catalase (CAT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [71]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [72]
Haloperidol DM96SE0 Delirium Approved [32]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [73]
Selenium DM25CGV N. A. N. A. Approved [74]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [75]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [76]
Methotrexate DM2TEOL Anterior urethra cancer Approved [26]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [77]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
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Drug(s) Affected By Heat shock protein beta-1 (HSPB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [79]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [80]
Selenium DM25CGV N. A. N. A. Approved [81]
Methotrexate DM2TEOL Anterior urethra cancer Approved [82]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [84]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [85]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [86]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [87]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [88]
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Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [89]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [90]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [91]
Methotrexate DM2TEOL Anterior urethra cancer Approved [92]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [93]
Quercetin DM3NC4M Obesity 5B81 Approved [94]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [95]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [96]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [97]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
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Drug(s) Affected By Annexin A5 (ANXA5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [80]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [99]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [54]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [100]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Benzatropine DMF7EXL Parkinsonian disorder Approved [103]
Clozapine DMFC71L Schizophrenia 6A20 Approved [103]
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Drug(s) Affected By Heat shock 70 kDa protein 1A (HSPA1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [104]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [106]
Gefitinib DM15F0X Colon adenocarcinoma Approved [107]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [108]
Selenium DM25CGV N. A. N. A. Approved [81]
Etretinate DM2CZFA Keratosis ED56 Approved [109]
Methotrexate DM2TEOL Anterior urethra cancer Approved [26]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [54]
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Drug(s) Affected By 60 kDa heat shock protein, mitochondrial (HSPD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [110]
Etretinate DM2CZFA Keratosis ED56 Approved [109]
Methotrexate DM2TEOL Anterior urethra cancer Approved [111]
Quercetin DM3NC4M Obesity 5B81 Approved [112]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [54]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [113]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [114]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [115]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [84]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [116]
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Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [117]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [118]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [119]
Etretinate DM2CZFA Keratosis ED56 Approved [109]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [120]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [121]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [122]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [123]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [124]
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Drug(s) Affected By Early growth response protein 1 (EGR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [108]
Methotrexate DM2TEOL Anterior urethra cancer Approved [111]
Quercetin DM3NC4M Obesity 5B81 Approved [125]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [54]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [55]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [126]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [127]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [128]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [100]
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Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [129]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [130]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [106]
Gefitinib DM15F0X Colon adenocarcinoma Approved [131]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [132]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [133]
Methotrexate DM2TEOL Anterior urethra cancer Approved [48]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [134]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [135]
Quercetin DM3NC4M Obesity 5B81 Approved [69]
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Drug(s) Affected By Glutathione S-transferase Mu 3 (GSTM3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [54]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [55]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [136]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [140]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [141]
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Drug(s) Affected By Cyclin-C (CCNC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [142]
Testosterone DM7HUNW Hot flushes GA30 Approved [143]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [144]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [145]
Dihydroxyacetone DMM1LG2 Sunburn EJ40 Approved [146]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [147]
Arsenic DMTL2Y1 N. A. N. A. Approved [148]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [149]
Inecalcitol oral DMU5SZP Acute myeloid leukaemia 2A60 Phase 2 [150]
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Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Triacetin DM0AEPG Onychomycosis EE12.1 Approved [151]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [106]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [152]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [118]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [108]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [120]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [153]
Methotrexate DM2TEOL Anterior urethra cancer Approved [154]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
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Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [155]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [156]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [157]
Gefitinib DM15F0X Colon adenocarcinoma Approved [158]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [159]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [108]
Etretinate DM2CZFA Keratosis ED56 Approved [160]
Prednisone DM2HG4X Acute asthma CA23 Approved [161]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [162]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [163]
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Drug(s) Affected By Heat shock-related 70 kDa protein 2 (HSPA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Quercetin DM3NC4M Obesity 5B81 Approved [165]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [55]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [167]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [168]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [169]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
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Drug(s) Affected By Actin, cytoplasmic 1 (ACTB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [132]
Selenium DM25CGV N. A. N. A. Approved [81]
Etretinate DM2CZFA Keratosis ED56 Approved [109]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [170]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [128]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
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Drug(s) Affected By 10 kDa heat shock protein, mitochondrial (HSPE1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Quercetin DM3NC4M Obesity 5B81 Approved [172]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [113]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [100]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [113]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Ethanol DMDRQZU Chronic pain MG30 Approved [173]
Folic Acid DMEMBJC Colorectal carcinoma Approved [174]
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Drug(s) Affected By E3 ubiquitin-protein ligase Mdm2 (MDM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [175]
Flucytosine DM13VTW Cryptococcal meningitis Approved [176]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [176]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [177]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [178]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [179]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [84]
Amifostine DM5FL14 Mucositis CA00 Approved [180]
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Drug(s) Affected By Serine-protein kinase ATM (ATM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [181]
Paromomycin DM1AGXN Amoebiasis 1A36 Approved [182]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [183]
Etretinate DM2CZFA Keratosis ED56 Approved [160]
Quercetin DM3NC4M Obesity 5B81 Approved [184]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [185]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [186]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [84]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [56]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [187]
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Drug(s) Affected By Interleukin-18 (IL18)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [175]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [132]
Methotrexate DM2TEOL Anterior urethra cancer Approved [26]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [188]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [189]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [190]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [191]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [192]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [193]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [192]
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Drug(s) Affected By Growth/differentiation factor 15 (GDF15)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [108]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [163]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [194]
Quercetin DM3NC4M Obesity 5B81 Approved [195]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [196]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [197]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [197]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [198]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [130]
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Drug(s) Affected By C-X-C motif chemokine 11 (CXCL11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [26]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Testosterone DM7HUNW Hot flushes GA30 Approved [199]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [200]
Tofacitinib DMBS370 Rheumatoid arthritis FA20 Approved [201]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [202]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [203]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [203]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [204]
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Drug(s) Affected By C-X-C motif chemokine 10 (CXCL10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [205]
Quercetin DM3NC4M Obesity 5B81 Approved [206]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [54]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [207]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [208]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [209]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Tofacitinib DMBS370 Rheumatoid arthritis FA20 Approved [201]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
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Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [210]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [64]
Gefitinib DM15F0X Colon adenocarcinoma Approved [211]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [68]
Selenium DM25CGV N. A. N. A. Approved [212]
Pentosan Polysulfate DM2HRKE Interstitial cystitis GC00.3 Approved [213]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [214]
Methotrexate DM2TEOL Anterior urethra cancer Approved [215]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [216]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [217]
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Drug(s) Affected By Interleukin-10 (IL10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [36]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [205]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [218]
Methotrexate DM2TEOL Anterior urethra cancer Approved [82]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [219]
Quercetin DM3NC4M Obesity 5B81 Approved [220]
Bisoprolol DM3UZ95 Hypertension BA00-BA04 Approved [221]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [222]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [223]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [208]
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Drug(s) Affected By Dual specificity protein phosphatase 1 (DUSP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [106]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [225]
Methotrexate DM2TEOL Anterior urethra cancer Approved [82]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [226]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [227]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [228]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [86]
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Drug(s) Affected By Oxidized purine nucleoside triphosphate hydrolase (NUDT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Testosterone DM7HUNW Hot flushes GA30 Approved [199]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [199]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
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Drug(s) Affected By Forkhead box protein M1 (FOXM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [230]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [108]
Methotrexate DM2TEOL Anterior urethra cancer Approved [154]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [231]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [169]
Testosterone DM7HUNW Hot flushes GA30 Approved [199]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [232]
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Drug(s) Affected By Delta(24)-sterol reductase (DHCR24)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [81]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [233]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Fluoxetine DM3PD2C Bipolar depression Approved [234]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [115]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [235]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [236]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
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Drug(s) Affected By Scavenger receptor class A member 3 (SCARA3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [184]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [231]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [237]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [86]
Testosterone DM7HUNW Hot flushes GA30 Approved [199]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [199]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [238]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [239]
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Drug(s) Affected By Lactoperoxidase (LPO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [240]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [240]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [240]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [240]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [240]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [141]
Sulfadiazine DMTW3R8 Rheumatic fever 1B40-1B42 Approved [240]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [240]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [241]
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Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [242]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [243]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [244]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [71]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [245]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [246]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [247]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [248]
Quercetin DM3NC4M Obesity 5B81 Approved [249]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [250]
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Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [244]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [251]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [252]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [253]
Quercetin DM3NC4M Obesity 5B81 Approved [254]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [255]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [116]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [79]
Verapamil DMA7PEW Angina pectoris BA40 Approved [256]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [106]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [71]
Selenium DM25CGV N. A. N. A. Approved [81]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [257]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [247]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [248]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [258]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glucocorticoid receptor (NR3C1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [259]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [64]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Selenium DM25CGV N. A. N. A. Approved [81]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [260]
Methotrexate DM2TEOL Anterior urethra cancer Approved [26]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [261]
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Drug(s) Affected By Tyrosine aminotransferase (TAT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Colchicine DM2POTE Acute gout flare FA25.0 Approved [262]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [128]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [263]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [264]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [265]
Miconazole DMPMYE8 Cutaneous candidiasis 1F23.14 Approved [266]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [267]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [268]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [269]
Quercetin DM3NC4M Obesity 5B81 Approved [270]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [271]
Artemether DM48QOT Malaria 1F40-1F45 Approved [272]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [273]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [97]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [274]
Estrone DM5T6US Acne vulgaris ED80 Approved [275]
Leflunomide DMR8ONJ Arthritis FA20 Approved [276]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
Selenium DM25CGV N. A. N. A. Approved [277]
Methotrexate DM2TEOL Anterior urethra cancer Approved [278]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [248]
Epinephrine DM3KJBC Acute asthma CA23 Approved [279]
Quercetin DM3NC4M Obesity 5B81 Approved [280]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [250]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [95]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [281]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [226]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [282]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [283]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [284]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [285]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [286]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [287]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [288]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [289]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [290]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [291]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-8 (CASP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [292]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [293]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [294]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [175]
Gefitinib DM15F0X Colon adenocarcinoma Approved [295]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [296]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [297]
Selenium DM25CGV N. A. N. A. Approved [81]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [298]
Methotrexate DM2TEOL Anterior urethra cancer Approved [26]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Casein kinase II subunit alpha' (CSNK2A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [194]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [86]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [299]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [300]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [47]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutathione reductase, mitochondrial (GSR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [301]
Ketoprofen DMRKXPT Bursitis Approved [32]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [73]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [302]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [252]
Quercetin DM3NC4M Obesity 5B81 Approved [303]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [95]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [304]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [84]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [305]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutathione peroxidase 1 (GPX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [306]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [307]
Amlexanox DM0DQM5 Respiratory tract inflammation CA07 Approved [308]
Selenium DM25CGV N. A. N. A. Approved [309]
Methotrexate DM2TEOL Anterior urethra cancer Approved [310]
Quercetin DM3NC4M Obesity 5B81 Approved [311]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [54]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [312]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [313]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [314]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Activator of apoptosis harakiri (HRK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [84]
Panobinostat DM58WKG Chronic graft versus host disease Approved [315]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [316]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [317]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [84]
Folic Acid DMEMBJC Colorectal carcinoma Approved [318]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [319]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Toll-like receptor 4 (TLR4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [26]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [320]
Quercetin DM3NC4M Obesity 5B81 Approved [321]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [86]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [322]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [8]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [320]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [242]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [323]
Vismodegib DM5IXKQ Basal cell carcinoma 2C32 Approved [324]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [325]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [326]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [327]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [328]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA fragmentation factor subunit alpha (DFFA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Menthol DMG2KW7 Back pain ME84.Z Approved [329]
Capsaicin DMGMF6V Back pain ME84.Z Approved [330]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [331]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [175]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [64]
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [332]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [333]
Methotrexate DM2TEOL Anterior urethra cancer Approved [334]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [335]
Quercetin DM3NC4M Obesity 5B81 Approved [195]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [336]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Panobinostat DM58WKG Chronic graft versus host disease Approved [315]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dynamin-1-like protein (DNM1L)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [337]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [338]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [339]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Efavirenz DMC0GSJ Human immunodeficiency virus infection 1C62 Approved [340]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Ethanol DMDRQZU Chronic pain MG30 Approved [341]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [268]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [337]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [342]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome c oxidase subunit NDUFA4 (NDUFA4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [81]
Quercetin DM3NC4M Obesity 5B81 Approved [195]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [128]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [141]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [343]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [344]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [345]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myc box-dependent-interacting protein 1 (BIN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Selenium DM25CGV N. A. N. A. Approved [81]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [346]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Ethanol DMDRQZU Chronic pain MG30 Approved [347]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
Paclitaxel DMLB81S Breast carcinoma Approved [348]
Bortezomib DMNO38U Leukemia Approved [349]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor SOX-1 (SOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [111]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [231]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [350]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [351]
Arsenic DMTL2Y1 N. A. N. A. Approved [352]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [353]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [315]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [315]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-dependent RNA helicase DDX3X (DDX3X)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [354]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [355]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [356]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [141]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [147]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [357]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CCN family member 1 (CCN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [108]
Methotrexate DM2TEOL Anterior urethra cancer Approved [278]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [358]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [278]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [128]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [168]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [200]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Stearoyl-CoA desaturase (SCD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Clavulanate DM2FGRT Bacteremia 1A73 Approved [252]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [359]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [359]
Methotrexate DM2TEOL Anterior urethra cancer Approved [26]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [250]
Fluoxetine DM3PD2C Bipolar depression Approved [359]
Fructose DM43AN2 Vomiting MD90 Approved [360]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [361]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [359]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apoptotic protease-activating factor 1 (APAF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [175]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [195]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [362]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [363]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [364]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [328]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [317]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [163]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [365]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [175]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [152]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [366]
Selenium DM25CGV N. A. N. A. Approved [367]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [163]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [368]
Methotrexate DM2TEOL Anterior urethra cancer Approved [111]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [368]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By U6 snRNA-associated Sm-like protein LSm1 (LSM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [369]
[3H]methyltrienolone DMTSGOW Discovery agent N.A. Investigative [370]
Drug(s) Affected By Centrin-3 (CETN3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ethanol DMDRQZU Chronic pain MG30 Approved [371]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [145]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [372]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [372]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [373]
methyl p-hydroxybenzoate DMO58UW Discovery agent N.A. Investigative [374]
Deguelin DMXT7WG Esophageal squamous cell carcinoma 2E60.1 Investigative [375]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein SLC31A2 (SLC31A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [376]
Methotrexate DM2TEOL Anterior urethra cancer Approved [82]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [185]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [377]
Testosterone DM7HUNW Hot flushes GA30 Approved [199]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [199]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [378]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [238]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Toll-like receptor 3 (TLR3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [346]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [128]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [237]
Testosterone DM7HUNW Hot flushes GA30 Approved [199]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [379]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Testosterone enanthate DMB6871 N. A. N. A. Approved [380]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ethanol DMDRQZU Chronic pain MG30 Approved [381]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor MafG (MAFG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [244]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [108]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [185]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [97]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [242]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [382]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Receptor-interacting serine/threonine-protein kinase 2 (RIPK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [278]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [185]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [278]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [200]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Menthol DMG2KW7 Back pain ME84.Z Approved [329]
Capsaicin DMGMF6V Back pain ME84.Z Approved [383]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine protease HTRA2, mitochondrial (HTRA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [79]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [339]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [136]
Testosterone DM7HUNW Hot flushes GA30 Approved [199]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [199]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [384]
Bortezomib DMNO38U Leukemia Approved [385]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [386]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [387]
Quercetin DM3NC4M Obesity 5B81 Approved [388]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [186]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [389]
Panobinostat DM58WKG Chronic graft versus host disease Approved [315]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [390]
Testosterone DM7HUNW Hot flushes GA30 Approved [143]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Maleylacetoacetate isomerase (GSTZ1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [391]
Quercetin DM3NC4M Obesity 5B81 Approved [392]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [115]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [393]
Testosterone DM7HUNW Hot flushes GA30 Approved [143]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [394]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [319]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein SCO2 homolog, mitochondrial (SCO2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [81]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [395]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [395]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [268]
Bezafibrate DMZDCS0 Hypercholesterolaemia 5C80.0 Approved [396]
Urethane DM7NSI0 N. A. N. A. Phase 4 [397]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aldo-keto reductase family 1 member B10 (AKR1B10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [398]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [252]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [336]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [399]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [208]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [237]
Reserpine DM6VM38 Hypertension BA00-BA04 Approved [400]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [191]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [382]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [401]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [185]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [402]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [84]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [403]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [404]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [200]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By E3 ubiquitin-protein ligase parkin (PRKN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Emtricitabine DMBMUWZ Hepatitis virus infection 1E50-1E51 Approved [405]
Tubocurarine DMBZIVP Anaesthesia 9A78.6 Approved [406]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ethanol DMDRQZU Chronic pain MG30 Approved [407]
Trifluoperazine DMKBYWI Anxiety Approved [408]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [409]
Methamphetamine DMPM4SK Anxiety Approved [410]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [411]
Arsenic DMTL2Y1 N. A. N. A. Approved [412]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [47]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lipid transferase CIDEA (CIDEA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [115]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Tolcapone DM8MNVO Parkinson disease 8A00.0 Approved [413]
Menthol DMG2KW7 Back pain ME84.Z Approved [329]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [129]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [414]
Arsenic DMTL2Y1 N. A. N. A. Approved [415]
PF-02545920 DMJPE61 Huntington disease 8A01.10 Phase 2 [416]
Delphinidin DMS2WIN Cardiovascular disease BA00-BE2Z Phase 2 [417]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [418]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Toll-like receptor 2 (TLR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [278]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [320]
Quercetin DM3NC4M Obesity 5B81 Approved [321]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [278]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [316]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [419]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [322]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [320]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Catenin delta-1 (CTNND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [401]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [420]
Methotrexate DM2TEOL Anterior urethra cancer Approved [111]
Quercetin DM3NC4M Obesity 5B81 Approved [421]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [164]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [422]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [423]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytohesin-interacting protein (CYTIP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Testosterone enanthate DMB6871 N. A. N. A. Approved [380]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [30]
Bortezomib DMNO38U Leukemia Approved [331]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [141]
Rigosertib DMOSTXF Myelodysplastic syndrome 2A37 Phase 3 [424]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [425]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [426]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [241]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [427]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nucleolar protein 3 (NOL3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [185]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Menthol DMG2KW7 Back pain ME84.Z Approved [329]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [428]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [422]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [429]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [47]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Microphthalmia-associated transcription factor (MITF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [430]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [431]
Quercetin DM3NC4M Obesity 5B81 Approved [195]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [432]
Vemurafenib DM62UG5 Melanoma 2C30 Approved [433]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [200]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hyaluronan mediated motility receptor (HMMR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [434]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [194]
Methotrexate DM2TEOL Anterior urethra cancer Approved [154]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [194]
Testosterone DM7HUNW Hot flushes GA30 Approved [199]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [199]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sperm-associated antigen 7 (SPAG7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [238]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [47]
Urethane DM7NSI0 N. A. N. A. Phase 4 [397]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [81]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [421]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [238]
Milchsaure DM462BT Pruritus EC90 Investigative [435]
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Drug(s) Affected By Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [436]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [106]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [437]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [118]
Quercetin DM3NC4M Obesity 5B81 Approved [438]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [118]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [185]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [439]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [440]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [118]
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Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Verapamil DMA7PEW Angina pectoris BA40 Approved [441]
Vidarabine DM0N85H Hepatosplenic T-cell lymphoma Approved [441]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [442]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [443]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [444]
Etidronic acid DM1XHYJ Bone Paget disease Approved [441]
Tiaprofenic acid DM23D7J Osteoarthritis FA00-FA05 Approved [441]
Bromperidol DM24XYQ Schizophrenia 6A20 Approved [441]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [269]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [445]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 21 (TNFRSF21)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [446]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [447]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [200]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [242]
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Drug(s) Affected By Epididymal secretory glutathione peroxidase (GPX5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [392]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [241]
THIOCTIC ACID DMNFCXW Discovery agent N.A. Investigative [448]
Drug(s) Affected By Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [106]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [366]
Methotrexate DM2TEOL Anterior urethra cancer Approved [154]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [136]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [237]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [228]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [449]
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Drug(s) Affected By Protein SCO1 homolog, mitochondrial (SCO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Folic Acid DMEMBJC Colorectal carcinoma Approved [450]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Arsenic DMTL2Y1 N. A. N. A. Approved [412]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [268]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [451]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [452]
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Drug(s) Affected By PRA1 family protein 3 (ARL6IP5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [453]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [404]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [449]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [454]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [455]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ubiquitin-like protein ATG12 (ATG12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [456]
Selenium DM25CGV N. A. N. A. Approved [81]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [457]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [458]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [459]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [460]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Artesunate DMR27C8 Infection of P. falciparum 1F40 Approved [461]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [422]
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Drug(s) Affected By Myelin protein zero-like protein 1 (MPZL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [111]
Quercetin DM3NC4M Obesity 5B81 Approved [421]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [462]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [163]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [163]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [163]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ubiquitin-like modifier-activating enzyme ATG7 (ATG7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [463]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [456]
Quercetin DM3NC4M Obesity 5B81 Approved [464]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [97]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [457]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [465]
Promethazine DM6I5GR Hyperemesis gravidarum Approved [466]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [97]
Cantharidin DMBP5N3 Molluscum contagiosum infection 1E76 Approved [467]
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Drug(s) Affected By CCN family member 4 (CCN4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [468]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [469]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [128]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [236]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [470]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Folic Acid DMEMBJC Colorectal carcinoma Approved [468]
Indomethacin DMSC4A7 Bursitis Approved [471]
Arsenic DMTL2Y1 N. A. N. A. Approved [472]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [47]
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Drug(s) Affected By BAG family molecular chaperone regulator 4 (BAG4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [391]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [227]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Menthol DMG2KW7 Back pain ME84.Z Approved [329]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [428]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [473]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [47]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [241]
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Drug(s) Affected By A disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAMTS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [128]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [8]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Arsenic DMTL2Y1 N. A. N. A. Approved [474]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [475]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [47]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [8]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [241]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [401]
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Drug(s) Affected By C-X-C motif chemokine 14 (CXCL14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Panobinostat DM58WKG Chronic graft versus host disease Approved [315]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [231]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [200]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [30]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [476]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [477]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [307]
Indomethacin DMSC4A7 Bursitis Approved [478]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Claudin-1 (CLDN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [479]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [90]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Panobinostat DM58WKG Chronic graft versus host disease Approved [315]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [231]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [480]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [200]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
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Drug(s) Affected By B-cell lymphoma/leukemia 10 (BCL10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [434]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Testosterone DM7HUNW Hot flushes GA30 Approved [199]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [199]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Menthol DMG2KW7 Back pain ME84.Z Approved [329]
Capsaicin DMGMF6V Back pain ME84.Z Approved [383]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [307]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome c oxidase subunit 2 (COX2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [481]
Quercetin DM3NC4M Obesity 5B81 Approved [165]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [482]
Clarithromycin DM4M1SG Acute maxillary sinusitis Approved [483]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [449]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [484]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [483]
Menthol DMG2KW7 Back pain ME84.Z Approved [485]
Didanosine DMI2QPE Human immunodeficiency virus infection 1C62 Approved [486]
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Drug(s) Affected By Ornithine transcarbamylase, mitochondrial (OTC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [336]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [487]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [336]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [488]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [28]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [489]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [241]
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Drug(s) Affected By Tyrosine-protein kinase ABL1 (ABL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [32]
Anagrelide DMSQ8MD Thrombocythemia 3B63 Approved [32]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [490]
Quercetin DM3NC4M Obesity 5B81 Approved [165]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [128]
Testosterone DM7HUNW Hot flushes GA30 Approved [199]
Nilotinib DM7HXWT Chronic myelogenous leukaemia 2A20.0 Approved [491]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [199]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [492]
Capsaicin DMGMF6V Back pain ME84.Z Approved [383]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Angiotensinogen (AGT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [493]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [494]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Reboxetine DM26PRD Depression 6A70-6A7Z Approved [495]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [496]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [497]
Rhucin DM3ADGP Erectile dysfunction HA01.1 Approved [498]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Lisinopril DMUOK4C Chronic heart failure BD1Z Approved [499]
Irbesartan DMTP1DC Diabetic kidney disease GB61.Z Approved [500]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Metalloproteinase inhibitor 1 (TIMP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pentoxifylline DMU3DNC Alcoholic hepatitis DB94.1 Approved [32]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [33]
Verapamil DMA7PEW Angina pectoris BA40 Approved [501]
Selenium DM25CGV N. A. N. A. Approved [212]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [501]
Quercetin DM3NC4M Obesity 5B81 Approved [502]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [95]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [361]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [503]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [504]
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Drug(s) Affected By GTPase HRas (HRAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [505]
Selenium DM25CGV N. A. N. A. Approved [81]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [506]
Quercetin DM3NC4M Obesity 5B81 Approved [507]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [95]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [508]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [509]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [510]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [192]
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Drug(s) Affected By Low-density lipoprotein receptor (LDLR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [511]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [108]
Desogestrel DM27U4Y Contraception QA21 Approved [511]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [512]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [513]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [95]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [336]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [514]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [115]
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Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [515]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [32]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [516]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [517]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [518]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [519]
Prednisone DM2HG4X Acute asthma CA23 Approved [520]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [521]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [522]
Methotrexate DM2TEOL Anterior urethra cancer Approved [26]
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Drug(s) Affected By Lymphotoxin-alpha (LTA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [54]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [128]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [202]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [307]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [523]
Arsenic DMTL2Y1 N. A. N. A. Approved [415]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [343]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [429]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [524]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [524]
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Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [525]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [526]
Fructose DM43AN2 Vomiting MD90 Approved [32]
Ketoprofen DMRKXPT Bursitis Approved [32]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [527]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [528]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [529]
Gefitinib DM15F0X Colon adenocarcinoma Approved [211]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [530]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [68]
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Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [175]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [531]
Gefitinib DM15F0X Colon adenocarcinoma Approved [107]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [65]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [71]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [65]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [532]
Selenium DM25CGV N. A. N. A. Approved [277]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [533]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [534]
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Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [32]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [535]
Diazepam DM08E9O Alcohol withdrawal Approved [536]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [391]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [537]
Methotrexate DM2TEOL Anterior urethra cancer Approved [538]
Ceruletide DM2WE5K Caerulein stimulated gastric and pancreatic secretion 5A4Y Approved [539]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [540]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [541]
Quercetin DM3NC4M Obesity 5B81 Approved [542]
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Drug(s) Affected By Collagen alpha-1(III) chain (COL3A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [535]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [543]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [544]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [545]
Quercetin DM3NC4M Obesity 5B81 Approved [546]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [547]
Testosterone DM7HUNW Hot flushes GA30 Approved [548]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [236]
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [549]
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Drug(s) Affected By Collagen alpha-1(IV) chain (COL4A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [391]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [185]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [550]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [242]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [551]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
Paclitaxel DMLB81S Breast carcinoma Approved [348]
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Drug(s) Affected By Fibronectin (FN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [552]
Methotrexate DM2TEOL Anterior urethra cancer Approved [26]
Quercetin DM3NC4M Obesity 5B81 Approved [195]
Aripiprazole DM3NUMH Bipolar I disorder Approved [553]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [554]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [555]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [115]
Ethacrynic acid DM60QMR Edema MG29 Approved [556]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [305]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [168]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transferrin receptor protein 1 (TFRC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [157]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [557]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [320]
Quercetin DM3NC4M Obesity 5B81 Approved [165]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [250]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [558]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [115]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [84]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [559]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [560]
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Drug(s) Affected By Metallothionein-2 (MT2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [561]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [108]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [562]
Quercetin DM3NC4M Obesity 5B81 Approved [563]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [54]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [84]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [136]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [169]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [242]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NADH-ubiquinone oxidoreductase chain 1 (ND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [481]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [482]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [355]
Chloramphenicol DMFXEWT Bacterial infection 1A00-1C4Z Approved [564]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [343]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [47]
Capsaicin DMGMF6V Back pain ME84.Z Approved [565]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [32]
Haloperidol DM96SE0 Delirium Approved [32]
Thiothixene DMDINC4 Schizophrenia 6A20 Approved [32]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NADH-ubiquinone oxidoreductase chain 2 (ND2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [482]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [449]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [355]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [343]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [47]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [451]
3R14S-OCHRATOXIN A DM2KEW6 Discovery agent N.A. Investigative [566]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [567]
methyl p-hydroxybenzoate DMO58UW Discovery agent N.A. Investigative [374]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interstitial collagenase (MMP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [568]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [569]
Etretinate DM2CZFA Keratosis ED56 Approved [570]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [571]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [572]
Quercetin DM3NC4M Obesity 5B81 Approved [573]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [574]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [575]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [393]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Granulocyte-macrophage colony-stimulating factor (CSF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [36]
Quercetin DM3NC4M Obesity 5B81 Approved [576]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [54]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [577]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [578]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [579]
Testosterone DM7HUNW Hot flushes GA30 Approved [143]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [580]
Acetylcholine DMDF79Z Cataract 9B10 Approved [581]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [582]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein S100-B (S100B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Panobinostat DM58WKG Chronic graft versus host disease Approved [315]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [128]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [236]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [350]
Norepinephrine DMOUC09 Alopecia ED70 Approved [583]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [584]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [88]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [88]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [585]
Methotrexate DM2TEOL Anterior urethra cancer Approved [26]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [179]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [586]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [285]
Paclitaxel DMLB81S Breast carcinoma Approved [587]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [588]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [589]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [590]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [591]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Metallothionein-1E (MT1E)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [84]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [592]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [593]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [594]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [595]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [596]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [597]
Riluzole DMECBWN Amyotrophic lateral sclerosis 8B60.0 Approved [598]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [599]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [600]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [601]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [54]
Ethacrynic acid DM60QMR Edema MG29 Approved [602]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [100]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [603]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [604]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome b-245 heavy chain (CYBB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [605]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [361]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [128]
Ethanol DMDRQZU Chronic pain MG30 Approved [606]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [141]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [607]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [361]
Dalcetrapib DMKNCVM Acute coronary syndrome BA41 Phase 3 [608]
Anacetrapib DMP2BFG Arteriosclerosis BD40 Phase 3 [608]
phorbol 12-myristate 13-acetate DMJWD62 Acute myeloid leukaemia 2A60 Phase 2 [609]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Amyloid-beta precursor protein (APP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [132]
Selenium DM25CGV N. A. N. A. Approved [81]
Methotrexate DM2TEOL Anterior urethra cancer Approved [26]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [610]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [611]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [612]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [613]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [128]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [614]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apolipoprotein D (APOD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [110]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [197]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [202]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [615]
Paclitaxel DMLB81S Breast carcinoma Approved [348]
Chloroquine DMSI5CB Malaria 1F40-1F45 Approved [616]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [307]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [110]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [617]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein S100-A8 (S100A8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [618]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [358]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [618]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [197]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [197]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [619]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [449]
Halothane DM80OZ5 Anaesthesia 9A78.6 Approved [618]
Dicloxacillin DM8EU0Z Bacterial infection 1A00-1C4Z Approved [618]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [200]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-4 (IL4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [620]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [519]
Tolnaftate DM28MU7 Dermatophytosis 1F28.2 Approved [621]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [218]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [622]
Prednisone DM2HG4X Acute asthma CA23 Approved [623]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [624]
Methotrexate DM2TEOL Anterior urethra cancer Approved [26]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [625]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [626]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [106]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [110]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [627]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [628]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [55]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [558]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [439]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [114]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [629]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-6 (IL6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [278]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [630]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [631]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [632]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [531]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [68]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [532]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [251]
Methotrexate DM2TEOL Anterior urethra cancer Approved [278]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor Jun (JUN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [633]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [634]
Fructose DM43AN2 Vomiting MD90 Approved [32]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [635]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [636]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [106]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [157]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [446]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [637]
Methotrexate DM2TEOL Anterior urethra cancer Approved [638]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor AP-2-alpha (TFAP2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [639]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [640]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [641]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [642]
Panobinostat DM58WKG Chronic graft versus host disease Approved [315]
Paroxetine DM5PVQE Anxiety disorder 6B00-6B0Z Approved [639]
Testosterone DM7HUNW Hot flushes GA30 Approved [143]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [236]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [242]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [242]
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Drug(s) Affected By Collagen alpha-2(V) chain (COL5A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [115]
Panobinostat DM58WKG Chronic graft versus host disease Approved [315]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [237]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [191]
Testosterone enanthate DMB6871 N. A. N. A. Approved [380]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ethanol DMDRQZU Chronic pain MG30 Approved [643]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [238]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [644]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA polymerase beta (POLB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [165]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [191]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Arsenic DMTL2Y1 N. A. N. A. Approved [645]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [646]
Colistin DMMD9QE Pseudomonas infection 1B92 Approved [32]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [647]
4-hydroxy-2-nonenal DM2LJFZ Discovery agent N.A. Investigative [132]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [369]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tyrosine 3-monooxygenase (TH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zonisamide DM0DTF7 Alcohol dependence 6C40.2 Approved [648]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [649]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [650]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [651]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [191]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [492]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [462]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [350]
Methamphetamine DMPM4SK Anxiety Approved [652]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [653]
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Drug(s) Affected By Cathepsin D (CTSD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [654]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [434]
Quercetin DM3NC4M Obesity 5B81 Approved [655]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [361]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [656]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [657]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [658]
Testosterone DM7HUNW Hot flushes GA30 Approved [143]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Calpain-1 catalytic subunit (CAPN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [117]
Selenium DM25CGV N. A. N. A. Approved [81]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [122]
Quercetin DM3NC4M Obesity 5B81 Approved [388]
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [659]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [363]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [660]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Cantharidin DMBP5N3 Molluscum contagiosum infection 1E76 Approved [661]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
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Drug(s) Affected By Pulmonary surfactant-associated protein B (SFTPB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [26]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [662]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Terbutaline DMD4381 Asthma CA23 Approved [663]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [663]
Cholecalciferol DMGU74E Adult acute monocytic leukemia Approved [664]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [665]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [664]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [664]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [204]
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Drug(s) Affected By DNA excision repair protein ERCC-1 (ERCC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [81]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [115]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [315]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [666]
Pemetrexed DMMX2E6 Central nervous system lymphoma 2B33.5 Approved [667]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [668]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [669]
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Drug(s) Affected By Thrombospondin-1 (THBS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [64]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [90]
Methotrexate DM2TEOL Anterior urethra cancer Approved [26]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [358]
Quercetin DM3NC4M Obesity 5B81 Approved [670]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [197]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [278]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [197]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [404]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [86]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Rhodopsin (RHO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [373]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [241]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [671]
Milchsaure DM462BT Pruritus EC90 Investigative [435]
Drug(s) Affected By Collagen alpha-2(I) chain (COL1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [185]
Panobinostat DM58WKG Chronic graft versus host disease Approved [315]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [128]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [236]
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [549]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [8]
Testosterone enanthate DMB6871 N. A. N. A. Approved [380]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [238]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Complement decay-accelerating factor (CD55)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [175]
Methotrexate DM2TEOL Anterior urethra cancer Approved [672]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [226]
Panobinostat DM58WKG Chronic graft versus host disease Approved [315]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [508]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [449]
Testosterone DM7HUNW Hot flushes GA30 Approved [143]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Amino acid transporter heavy chain SLC3A2 (SLC3A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [81]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [194]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [377]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [673]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [84]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [673]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [86]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [242]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Asparagine synthetase (ASNS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [674]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [110]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [674]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [194]
Methotrexate DM2TEOL Anterior urethra cancer Approved [278]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [675]
Fluoxetine DM3PD2C Bipolar depression Approved [674]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neutrophil elastase (ELANE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [141]
Glyceryl trinitrate DMF72W3 N. A. N. A. Phase 4 [676]
Lipoteichoic acid DMEMRW0 Solid tumour/cancer 2A00-2F9Z Phase 1/2 [677]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [241]
KOJIC ACID DMP84CS Discovery agent N.A. Investigative [678]
fMet-Leu-Phe DMQ391A N. A. N. A. Investigative [679]
Aniline DMLCAR9 N. A. N. A. Investigative [680]
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Drug(s) Affected By 72 kDa type IV collagenase (MMP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [569]
Selenium DM25CGV N. A. N. A. Approved [212]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [681]
Quercetin DM3NC4M Obesity 5B81 Approved [682]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [683]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [684]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [115]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [503]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [504]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [685]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Extracellular superoxide dismutase (SOD3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [392]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [361]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [508]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [236]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [382]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [30]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [301]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [686]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Inhibin beta A chain (INHBA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [128]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [237]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [200]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [687]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [462]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [238]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [428]
Arsenic DMTL2Y1 N. A. N. A. Approved [688]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Monocyte differentiation antigen CD14 (CD14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [106]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [95]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [689]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [136]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [690]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [691]
Testosterone DM7HUNW Hot flushes GA30 Approved [199]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [692]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fibroblast growth factor 2 (FGF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [693]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [156]
Diazepam DM08E9O Alcohol withdrawal Approved [536]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [694]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [695]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [696]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [136]
Isradipine DMA5XGH Hypertension BA00-BA04 Approved [697]
Valdecoxib DMAY7H4 Osteoarthritis FA00-FA05 Approved [698]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Growth-regulated alpha protein (CXCL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [90]
Selenium DM25CGV N. A. N. A. Approved [277]
Methotrexate DM2TEOL Anterior urethra cancer Approved [111]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [250]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [197]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [278]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [197]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [223]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heme oxygenase 1 (HMOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [129]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [631]
Verapamil DMA7PEW Angina pectoris BA40 Approved [256]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [531]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
Selenium DM25CGV N. A. N. A. Approved [699]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [39]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [700]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Macrophage colony-stimulating factor 1 (CSF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [157]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [80]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [701]
Selenium DM25CGV N. A. N. A. Approved [81]
Methotrexate DM2TEOL Anterior urethra cancer Approved [26]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [97]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [702]
Testosterone DM7HUNW Hot flushes GA30 Approved [199]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [200]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Gefitinib DM15F0X Colon adenocarcinoma Approved [703]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [704]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [297]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [705]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [162]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [705]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [214]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [706]
Methotrexate DM2TEOL Anterior urethra cancer Approved [707]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [278]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [237]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [708]
Testosterone DM7HUNW Hot flushes GA30 Approved [548]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [709]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [710]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [711]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [712]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [631]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [636]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [531]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [65]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [71]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [713]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [65]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myb-related protein A (MYBL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [640]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [714]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Panobinostat DM58WKG Chronic graft versus host disease Approved [715]
Estrone DM5T6US Acne vulgaris ED80 Approved [640]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [716]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [449]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [454]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [714]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myb-related protein B (MYBL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [132]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [628]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [113]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [227]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [86]
Testosterone DM7HUNW Hot flushes GA30 Approved [199]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [113]
Exemestane DM9HPW3 Hormonally-responsive breast cancer 2C60-2C65 Approved [717]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [718]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone H1.4 (H1-4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [719]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [551]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [307]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [164]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [47]
Lucanthone DMZLBUO Solid tumour/cancer 2A00-2F9Z Approved [720]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [721]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [722]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [723]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [724]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [725]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [32]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Verapamil DMA7PEW Angina pectoris BA40 Approved [726]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [727]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [528]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [728]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Osteopontin (SPP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [535]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [64]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [333]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [729]
Quercetin DM3NC4M Obesity 5B81 Approved [184]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [730]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [361]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [731]
Panobinostat DM58WKG Chronic graft versus host disease Approved [315]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [613]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Thyroid hormone receptor beta (THRB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [350]
Panobinostat DM58WKG Chronic graft versus host disease Approved [315]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [732]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [733]
Testosterone DM7HUNW Hot flushes GA30 Approved [143]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [200]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ethanol DMDRQZU Chronic pain MG30 Approved [734]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interferon regulatory factor 1 (IRF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [361]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [128]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [404]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [449]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [200]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [492]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lysosome-associated membrane glycoprotein 1 (LAMP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [103]
Selenium DM25CGV N. A. N. A. Approved [81]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [185]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [457]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [735]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Ethanol DMDRQZU Chronic pain MG30 Approved [736]
Clozapine DMFC71L Schizophrenia 6A20 Approved [103]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [737]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Uteroglobin (SCGB1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [738]
Aluminium DM6ECN9 Hyperhidrosis EE00 Approved [739]
Arsenic DMTL2Y1 N. A. N. A. Approved [688]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [740]
Deoxythymidine DMR90HY Discovery agent N.A. Investigative [741]
Drug(s) Affected By Ornithine decarboxylase (ODC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [742]
Methotrexate DM2TEOL Anterior urethra cancer Approved [743]
Quercetin DM3NC4M Obesity 5B81 Approved [744]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [197]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [197]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [130]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [449]
Propranolol DM79NTF Angina pectoris BA40 Approved [745]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [87]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By High affinity immunoglobulin gamma Fc receptor I (FCGR1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [746]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [428]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [488]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [361]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [241]
Maleic Acid DM4L0R7 Discovery agent N.A. Investigative [747]
Rapamycin Immunosuppressant Drug DM678IB Discovery agent N.A. Investigative [746]
PHENCYCLIDINE DMQBEYX Discovery agent N.A. Investigative [748]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cadherin-1 (CDH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [391]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [749]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [750]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [751]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [752]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [753]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [185]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [754]
Panobinostat DM58WKG Chronic graft versus host disease Approved [315]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-7 (IL7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [223]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [702]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [202]
Ethanol DMDRQZU Chronic pain MG30 Approved [702]
Oxymetholone DMFXUT8 Aplastic anemia 3A70 Approved [755]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [30]
Isoproterenol DMK7MEY Atrioventricular block Approved [756]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome b-245 light chain (CYBA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [757]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [758]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [361]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [759]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [85]
Testosterone DM7HUNW Hot flushes GA30 Approved [143]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Testosterone enanthate DMB6871 N. A. N. A. Approved [380]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C motif chemokine 2 (CCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [632]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [64]
Gefitinib DM15F0X Colon adenocarcinoma Approved [760]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [68]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [519]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [708]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [39]
Methotrexate DM2TEOL Anterior urethra cancer Approved [26]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [761]
Quercetin DM3NC4M Obesity 5B81 Approved [206]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C motif chemokine 5 (CCL5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [157]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [762]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [205]
Methotrexate DM2TEOL Anterior urethra cancer Approved [26]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [763]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [361]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [207]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [764]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [765]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Secretogranin-2 (SCG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [185]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [231]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [315]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [372]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [307]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [478]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [47]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [766]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [241]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neural cell adhesion molecule 1 (NCAM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [470]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [454]
Folic Acid DMEMBJC Colorectal carcinoma Approved [318]
Arsenic DMTL2Y1 N. A. N. A. Approved [767]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [488]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [47]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [88]
Camptothecin DM6CHNJ Solid tumour/cancer 2A00-2F9Z Phase 3 [768]
phorbol 12-myristate 13-acetate DMJWD62 Acute myeloid leukaemia 2A60 Phase 2 [769]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Metallothionein-1G (MT1G)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [108]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [84]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [716]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [770]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [593]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glial fibrillary acidic protein (GFAP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Penicillin V DMKVOYF Acute otitis media AB00 Approved [32]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [32]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [771]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [772]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [773]
Testosterone DM7HUNW Hot flushes GA30 Approved [143]
Haloperidol DM96SE0 Delirium Approved [103]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Ethanol DMDRQZU Chronic pain MG30 Approved [347]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neutrophil cytosol factor 1 (NCF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [774]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [361]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [85]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [775]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ethanol DMDRQZU Chronic pain MG30 Approved [776]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [141]
Arsenic DMTL2Y1 N. A. N. A. Approved [767]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [634]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [777]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutamine synthetase (GLUL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [197]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [197]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [514]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [237]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [200]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Clozapine DMFC71L Schizophrenia 6A20 Approved [778]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fos-related antigen 1 (FOSL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [90]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [97]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [227]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [508]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [779]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [237]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [169]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor 4 (TCF4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [401]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [780]
Quercetin DM3NC4M Obesity 5B81 Approved [781]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [393]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [780]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [237]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Testosterone enanthate DMB6871 N. A. N. A. Approved [380]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [484]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NADPH--cytochrome P450 reductase (POR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [47]
Tacrolimus DMZ7XNQ Graft-versus-host disease 4B24 Approved [782]
Selenium DM25CGV N. A. N. A. Approved [81]
Quercetin DM3NC4M Obesity 5B81 Approved [783]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [54]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [361]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [404]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Platelet glycoprotein 4 (CD36)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [118]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [784]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [785]
Tolcapone DM8MNVO Parkinson disease 8A00.0 Approved [413]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [786]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [787]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [355]
Asasantin DMCZIHT Cerebrovascular ischaemia 8B1Z Approved [788]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CCAAT/enhancer-binding protein beta (CEBPB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Methotrexate DM2TEOL Anterior urethra cancer Approved [111]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [134]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [506]
Quercetin DM3NC4M Obesity 5B81 Approved [789]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [361]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [673]
Panobinostat DM58WKG Chronic graft versus host disease Approved [315]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutathione peroxidase 2 (GPX2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [244]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [108]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [252]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [95]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [336]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [790]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [791]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [97]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [237]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [108]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [194]
Methotrexate DM2TEOL Anterior urethra cancer Approved [715]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [358]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [562]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [336]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [84]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [106]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [152]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [132]
Selenium DM25CGV N. A. N. A. Approved [81]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [194]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [439]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [440]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [97]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [792]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [793]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [118]
Quercetin DM3NC4M Obesity 5B81 Approved [388]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [118]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [439]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [629]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [97]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [118]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [794]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [459]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [32]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [516]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [795]
Methotrexate DM2TEOL Anterior urethra cancer Approved [111]
Quercetin DM3NC4M Obesity 5B81 Approved [69]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [796]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [84]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [128]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [364]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [797]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor EB (TFEB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [81]
Fluphenazine DMIT8LX Psychotic disorder 6A20-6A25 Approved [408]
Prochlorperazine DM53SRA Nausea MD90 Approved [408]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [457]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [735]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [191]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [798]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [141]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [88]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-X-C motif chemokine 2 (CXCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Selenium DM25CGV N. A. N. A. Approved [277]
Methotrexate DM2TEOL Anterior urethra cancer Approved [111]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [278]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [619]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [799]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [191]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neutrophil cytosol factor 2 (NCF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [226]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [800]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [237]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [191]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [202]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [801]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [668]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [131]
Quercetin DM3NC4M Obesity 5B81 Approved [195]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [95]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [393]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [797]
Lenalidomide DM6Q7U4 Adult T-cell leukemia/lymphoma Approved [802]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [802]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ethanol DMDRQZU Chronic pain MG30 Approved [702]
Menthol DMG2KW7 Back pain ME84.Z Approved [329]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear receptor subfamily 1 group D member 1 (NR1D1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [803]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [804]
Prednisolone DMQ8FR2 Acute adrenal insufficiency Approved [805]
Chenodiol DMQ8JIK Cholelithiasis DC11 Approved [806]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [47]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interferon-induced GTP-binding protein Mx1 (MX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [81]
Methotrexate DM2TEOL Anterior urethra cancer Approved [278]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [278]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [807]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [404]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [237]
Testosterone DM7HUNW Hot flushes GA30 Approved [143]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [470]
Testosterone enanthate DMB6871 N. A. N. A. Approved [380]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proteasome subunit beta type-1 (PSMB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Etretinate DM2CZFA Keratosis ED56 Approved [109]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [508]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [191]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [488]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [47]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [808]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [809]
Paclitaxel DMLB81S Breast carcinoma Approved [809]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome P450 2B6 (CYP2B6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [810]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [811]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [812]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [813]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [814]
Clopidogrel DMOL54H Acute coronary syndrome BA41 Approved [815]
Artemisinin DMOY7W3 Malaria 1F40-1F45 Approved [816]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [817]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [818]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [819]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Collagen alpha-1(V) chain (COL5A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [115]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [8]
Testosterone enanthate DMB6871 N. A. N. A. Approved [380]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [820]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [238]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [644]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [307]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [428]
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Drug(s) Affected By Synaptotagmin-1 (SYT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [111]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [200]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Heroin diacetylmorphine DMDBWHY Neurological disorder 6B60 Approved [821]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Folic Acid DMEMBJC Colorectal carcinoma Approved [450]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [822]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [823]
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Drug(s) Affected By Cytochrome P450 7A1 (CYP7A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcipotriol DM03CP7 Psoriasis EA90 Approved [824]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [252]
Methotrexate DM2TEOL Anterior urethra cancer Approved [111]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [825]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [826]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [54]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [827]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [97]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [818]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [825]
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Drug(s) Affected By Prostaglandin G/H synthase 1 (PTGS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [828]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [61]
Quercetin DM3NC4M Obesity 5B81 Approved [392]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [54]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [55]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [197]
Bupivacaine DM4PRFC Anaesthesia 9A78.6 Approved [829]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [197]
Panobinostat DM58WKG Chronic graft versus host disease Approved [315]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [830]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [831]
Gefitinib DM15F0X Colon adenocarcinoma Approved [463]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [832]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [387]
Quercetin DM3NC4M Obesity 5B81 Approved [833]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [834]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [361]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [835]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [836]
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Drug(s) Affected By Brain-derived neurotrophic factor (BDNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Haloperidol DM96SE0 Delirium Approved [837]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [64]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [481]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Bupivacaine DM4PRFC Anaesthesia 9A78.6 Approved [838]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [839]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [86]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [200]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [191]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
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Drug(s) Affected By Chymase (CMA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [204]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [418]
Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [840]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [841]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [728]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [842]
Gefitinib DM15F0X Colon adenocarcinoma Approved [843]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [159]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [844]
Selenium DM25CGV N. A. N. A. Approved [81]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [845]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [846]
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Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [106]
Gefitinib DM15F0X Colon adenocarcinoma Approved [131]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [306]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [194]
Methotrexate DM2TEOL Anterior urethra cancer Approved [847]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [127]
Quercetin DM3NC4M Obesity 5B81 Approved [125]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [848]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [849]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tenascin (TNC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Diazepam DM08E9O Alcohol withdrawal Approved [536]
Methotrexate DM2TEOL Anterior urethra cancer Approved [26]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [250]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [185]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [250]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [709]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [687]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Capsaicin DMGMF6V Back pain ME84.Z Approved [375]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [30]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Signal transducer CD24 (CD24)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [110]
Methotrexate DM2TEOL Anterior urethra cancer Approved [111]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [850]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Panobinostat DM58WKG Chronic graft versus host disease Approved [315]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [851]
Testosterone DM7HUNW Hot flushes GA30 Approved [199]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [199]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [315]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Endothelin-1 receptor (EDNRA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [401]
Selenium DM25CGV N. A. N. A. Approved [81]
Fructose DM43AN2 Vomiting MD90 Approved [852]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [185]
Panobinostat DM58WKG Chronic graft versus host disease Approved [315]
Testosterone enanthate DMB6871 N. A. N. A. Approved [380]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [853]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [488]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear transcription factor Y subunit beta (NFYB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [361]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [854]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [422]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [855]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [489]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [361]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [855]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [391]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [108]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [297]
Methotrexate DM2TEOL Anterior urethra cancer Approved [856]
Epinephrine DM3KJBC Acute asthma CA23 Approved [857]
Quercetin DM3NC4M Obesity 5B81 Approved [184]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [858]
Fructose DM43AN2 Vomiting MD90 Approved [852]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [391]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [673]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Metallothionein-3 (MT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [392]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [361]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [592]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Gallium nitrate DMF9O6B Hypercalcaemia 5B91.0 Approved [859]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [238]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [860]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [861]
Arsenic DMTL2Y1 N. A. N. A. Approved [862]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [607]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 5 (CD40)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [175]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [320]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [863]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [658]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [864]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [320]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [202]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [865]
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Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fructose DM43AN2 Vomiting MD90 Approved [32]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [291]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [175]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [531]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [866]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [867]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [868]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [869]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA cytosine-5)-methyltransferase 1 (DNMT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [230]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [870]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [871]
Quercetin DM3NC4M Obesity 5B81 Approved [184]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [872]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [873]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [874]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [875]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [876]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Paired box protein Pax-6 (PAX6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [877]
Panobinostat DM58WKG Chronic graft versus host disease Approved [315]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [877]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [878]
Nilotinib DM7HXWT Chronic myelogenous leukaemia 2A20.0 Approved [877]
Ramelteon DM7IW9J Insomnia 7A00-7A0Z Approved [877]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [879]
Dabigatran DMDI6R4 Stroke 8B20 Approved [877]
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Drug(s) Affected By CD27 antigen (CD27)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [625]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Menthol DMG2KW7 Back pain ME84.Z Approved [329]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [880]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [803]
Bortezomib DMNO38U Leukemia Approved [881]
Arsenic DMTL2Y1 N. A. N. A. Approved [882]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [883]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [241]
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Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [884]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [885]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [430]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [528]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [886]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [887]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [888]
Gefitinib DM15F0X Colon adenocarcinoma Approved [889]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [890]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [891]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G0/G1 switch protein 2 (G0S2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Selenium DM25CGV N. A. N. A. Approved [277]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [336]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [312]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [508]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [237]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [200]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial (NDUFS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [481]
Quercetin DM3NC4M Obesity 5B81 Approved [892]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [482]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [115]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [136]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Tramadol DMRQD04 Osteoarthritis FA00-FA05 Approved [893]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [740]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [894]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [885]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [895]
Paclitaxel DMLB81S Breast carcinoma Approved [896]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [897]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [884]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [32]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [175]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [528]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [886]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CCN family member 2 (CCN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [64]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [90]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [336]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [346]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [278]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [898]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [237]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [105]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-1 (CASP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [175]
Gefitinib DM15F0X Colon adenocarcinoma Approved [107]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [899]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [532]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [38]
Quercetin DM3NC4M Obesity 5B81 Approved [195]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [514]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [900]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [901]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [189]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peroxiredoxin-6 (PRDX6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [902]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [95]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [903]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Ethanol DMDRQZU Chronic pain MG30 Approved [347]
Capsaicin DMGMF6V Back pain ME84.Z Approved [904]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [238]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [905]
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Drug(s) Affected By Peroxiredoxin-5, mitochondrial (PRDX5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [47]
Quercetin DM3NC4M Obesity 5B81 Approved [906]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [363]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [492]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Menthol DMG2KW7 Back pain ME84.Z Approved [329]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [907]
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Drug(s) Affected By Thioredoxin-dependent peroxide reductase, mitochondrial (PRDX3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [80]
Quercetin DM3NC4M Obesity 5B81 Approved [906]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [908]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [909]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [488]
Aminoglutethimide DMWFHMZ Cushing disease 5A70 Approved [910]
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Drug(s) Affected By G1/S-specific cyclin-D2 (CCND2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [434]
Selenium DM25CGV N. A. N. A. Approved [142]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [911]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [912]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [913]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [155]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [914]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [191]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Type-1 angiotensin II receptor (AGTR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [915]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [916]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Fructose DM43AN2 Vomiting MD90 Approved [852]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [185]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [231]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Estriol DMOEM2I Hormone deficiency 5A61.1 Approved [917]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [422]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By High affinity cationic amino acid transporter 1 (SLC7A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [194]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [558]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [84]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [128]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [242]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [200]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [242]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [918]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [919]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [589]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [728]
Gefitinib DM15F0X Colon adenocarcinoma Approved [920]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [832]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [921]
Selenium DM25CGV N. A. N. A. Approved [81]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [922]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [845]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peroxiredoxin-2 (PRDX2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [307]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [923]
Etretinate DM2CZFA Keratosis ED56 Approved [109]
Quercetin DM3NC4M Obesity 5B81 Approved [392]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [115]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [924]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [903]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C chemokine receptor type 7 (CCR7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [449]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [925]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [926]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [925]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [372]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Guanylate-binding protein 1 (GBP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [391]
Selenium DM25CGV N. A. N. A. Approved [81]
Methotrexate DM2TEOL Anterior urethra cancer Approved [278]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [346]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [278]
Testosterone DM7HUNW Hot flushes GA30 Approved [199]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [199]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Testosterone enanthate DMB6871 N. A. N. A. Approved [380]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [492]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cystathionine gamma-lyase (CTH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [80]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [115]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [84]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [116]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [237]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [105]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [242]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CD70 antigen (CD70)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [401]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [514]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [393]
Vemurafenib DM62UG5 Melanoma 2C30 Approved [927]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [687]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Menthol DMG2KW7 Back pain ME84.Z Approved [329]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [336]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor ligand superfamily member 8 (TNFSF8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [84]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [393]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [84]
Menthol DMG2KW7 Back pain ME84.Z Approved [329]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [331]
Arsenic DMTL2Y1 N. A. N. A. Approved [415]
phorbol 12-myristate 13-acetate DMJWD62 Acute myeloid leukaemia 2A60 Phase 2 [928]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [883]
PF-3758309 DM36PKZ Solid tumour/cancer 2A00-2F9Z Phase 1 [929]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Multidrug resistance-associated protein 1 (ABCC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [930]
Folic Acid DMEMBJC Colorectal carcinoma Approved [931]
Methotrexate DM2TEOL Anterior urethra cancer Approved [932]
Quercetin DM3NC4M Obesity 5B81 Approved [933]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [934]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [822]
Epirubicin DMPDW6T Solid tumour/cancer 2A00-2F9Z Approved [935]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [936]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [937]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [937]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone H2B type 1-B (H2BC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Methotrexate DM2TEOL Anterior urethra cancer Approved [154]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [202]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [551]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [141]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [164]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [740]
Bicalutamide DMZMSPF Prostate cancer 2C82.0 Approved [938]
Urethane DM7NSI0 N. A. N. A. Phase 4 [397]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA replication licensing factor MCM7 (MCM7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [568]
Selenium DM25CGV N. A. N. A. Approved [81]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [939]
Quercetin DM3NC4M Obesity 5B81 Approved [69]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [226]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [231]
Testosterone DM7HUNW Hot flushes GA30 Approved [199]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [199]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bifunctional epoxide hydrolase 2 (EPHX2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Selenium DM25CGV N. A. N. A. Approved [81]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [54]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Gemfibrozil DMD8Q3J Hyperlipidaemia 5C80 Approved [940]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [940]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [30]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Catenin beta-1 (CTNNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [635]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [132]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [941]
Quercetin DM3NC4M Obesity 5B81 Approved [184]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [684]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [942]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [943]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [944]
Testosterone DM7HUNW Hot flushes GA30 Approved [945]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [232]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-13 (IL13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [946]
Prednisone DM2HG4X Acute asthma CA23 Approved [947]
Methotrexate DM2TEOL Anterior urethra cancer Approved [948]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [949]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [950]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [951]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Budesonide DMJIBAW Allergic rhinitis CA08.0 Approved [952]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [949]
Ethambutol DMR87LC Pulmonary tuberculosis 1B10.Z Approved [950]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pulmonary surfactant-associated protein D (SFTPD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [953]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [547]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [488]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [607]
Methotrexate DM2TEOL Anterior urethra cancer Approved [32]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [954]
D-glucose DMMG2TO Discovery agent N.A. Investigative [955]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By Pro-adrenomedullin (ADM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [156]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [366]
Methotrexate DM2TEOL Anterior urethra cancer Approved [26]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [316]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [191]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [129]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mu-type opioid receptor (OPRM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Alvimopan DMHR8KW Gastrointestinal disease DE2Z Approved [956]
Fentanyl DM8WAHT Analgesia MB40.8 Approved [957]
Morphine DMRMS0L Advanced cancer 2A00-2F9Z Approved [958]
Methotrexate DM2TEOL Anterior urethra cancer Approved [111]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [959]
Butorphanol DM5KYPJ Pain MG30-MG3Z Approved [960]
Oliceridine DM6MDCF Acute pain MG31 Approved [957]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [961]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [962]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cystathionine beta-synthase (CBS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic DMTL2Y1 N. A. N. A. Approved [963]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [964]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [237]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Ethanol DMDRQZU Chronic pain MG30 Approved [734]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [336]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [30]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Copper-transporting ATPase 2 (ATP7B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [965]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [966]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Folic Acid DMEMBJC Colorectal carcinoma Approved [450]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [30]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aryl hydrocarbon receptor (AHR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [64]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [967]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [968]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [969]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [970]
Quercetin DM3NC4M Obesity 5B81 Approved [971]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [972]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [185]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [274]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [973]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Chitinase-3-like protein 1 (CHI3L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [226]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [115]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [974]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [619]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [86]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [236]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [551]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [975]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor 7 (TCF7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [209]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [419]
Testosterone DM7HUNW Hot flushes GA30 Approved [143]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [492]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [803]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [319]
Bortezomib DMNO38U Leukemia Approved [331]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [976]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [740]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ADP-ribosylation factor-like protein 2 (ARL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [47]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [977]
AHPN DM8G6O4 Discovery agent N.A. Investigative [978]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 3 (LTBR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [81]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [250]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Menthol DMG2KW7 Back pain ME84.Z Approved [329]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [145]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [880]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [979]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [979]
Diphenylpyraline DMW4X37 Allergic rhinitis CA08.0 Approved [980]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phospholipid hydroperoxide glutathione peroxidase GPX4 (GPX4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [309]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [981]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [982]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [128]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Gallium nitrate DMF9O6B Hypercalcaemia 5B91.0 Approved [859]
Trabectedin DMG3Y89 Leiomyosarcoma 2B58 Approved [983]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [60]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [537]
Quercetin DM3NC4M Obesity 5B81 Approved [984]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [985]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [986]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [987]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [858]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [988]
Stavudine DM6DEK9 Human immunodeficiency virus infection 1C62 Approved [989]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA-binding protein SMUBP-2 (IGHMBP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [111]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [990]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [991]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [401]
Deguelin DMXT7WG Esophageal squamous cell carcinoma 2E60.1 Investigative [375]
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Drug(s) Affected By Collagen alpha-1(XV) chain (COL15A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [86]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [470]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [492]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [238]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [644]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [307]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [992]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [993]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [8]
Methotrexate DM2TEOL Anterior urethra cancer Approved [994]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glial cell line-derived neurotrophic factor (GDNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [995]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [128]
Adenosine DMM2NSK Paroxysmal supraventricular tachycardia BC81.Z Approved [996]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [997]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [998]
Dextroamphetamine DMMIHVP Attention deficit hyperactivity disorder 6A05.Z Approved [999]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [1000]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [241]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [353]
cordycepin DM72Y01 Discovery agent N.A. Investigative [996]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [26]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [346]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [1001]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [30]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [1002]
Arsenic DMTL2Y1 N. A. N. A. Approved [1003]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [1004]
Diphenylpyraline DMW4X37 Allergic rhinitis CA08.0 Approved [980]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [1005]
Coprexa DMA0WEK Neurological disorder 6B60 Phase 3 [1006]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Delta-type opioid receptor (OPRD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [373]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [32]
Pilocarpine DMV9ADG Glaucoma/ocular hypertension 9C61 Approved [32]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [241]
DPDPE DMIRSNA Discovery agent N.A. Investigative [1007]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [401]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By Regulator of G-protein signaling 2 (RGS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Methotrexate DM2TEOL Anterior urethra cancer Approved [26]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [358]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [185]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1008]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [86]
Testosterone DM7HUNW Hot flushes GA30 Approved [143]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [1009]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [191]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Prostaglandin-H2 D-isomerase (PTGDS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [90]
Selenium DM25CGV N. A. N. A. Approved [81]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [115]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [236]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [191]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [462]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [615]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [47]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [607]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By T-lymphocyte activation antigen CD86 (CD86)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1010]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [205]
Kanamycin DM2DMPO Bacteremia 1A73 Approved [1011]
Methotrexate DM2TEOL Anterior urethra cancer Approved [26]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [320]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [1011]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [393]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [1011]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [200]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Signal transducer and activator of transcription 1-alpha/beta (STAT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [110]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1012]
Methotrexate DM2TEOL Anterior urethra cancer Approved [278]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [134]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [1013]
Quercetin DM3NC4M Obesity 5B81 Approved [125]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1014]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [278]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [237]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [687]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [1015]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [516]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [831]
Gefitinib DM15F0X Colon adenocarcinoma Approved [463]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1016]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [845]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [240]
Quercetin DM3NC4M Obesity 5B81 Approved [1017]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [508]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [459]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-2 (CASP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [727]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1018]
Methotrexate DM2TEOL Anterior urethra cancer Approved [111]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [1019]
Quercetin DM3NC4M Obesity 5B81 Approved [1020]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [1021]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [86]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [1022]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [1023]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [635]
Gefitinib DM15F0X Colon adenocarcinoma Approved [211]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [637]
Quercetin DM3NC4M Obesity 5B81 Approved [69]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [114]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [1024]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [637]
Ethacrynic acid DM60QMR Edema MG29 Approved [1025]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 9 (MAPK9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [635]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [132]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [637]
Methotrexate DM2TEOL Anterior urethra cancer Approved [1026]
Quercetin DM3NC4M Obesity 5B81 Approved [1027]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [637]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1028]
Sorbitol DMAN0DE Constipation DD91.1 Approved [1029]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neurogenic locus notch homolog protein 1 (NOTCH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1030]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1031]
Propranolol DM79NTF Angina pectoris BA40 Approved [1032]
Testosterone DM7HUNW Hot flushes GA30 Approved [143]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [1033]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [1034]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
Mebendazole DMO14SG Ascariasis 1F62 Approved [1035]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [401]
Gefitinib DM15F0X Colon adenocarcinoma Approved [295]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1036]
Epinephrine DM3KJBC Acute asthma CA23 Approved [857]
Quercetin DM3NC4M Obesity 5B81 Approved [1037]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [54]
Fructose DM43AN2 Vomiting MD90 Approved [852]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1038]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [1039]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [1040]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [244]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [446]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [252]
Quercetin DM3NC4M Obesity 5B81 Approved [1041]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [115]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [84]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [613]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [716]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [1042]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nestin (NES)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [156]
Quercetin DM3NC4M Obesity 5B81 Approved [1043]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [350]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [136]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Testosterone enanthate DMB6871 N. A. N. A. Approved [380]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Clozapine DMFC71L Schizophrenia 6A20 Approved [103]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fatty acid synthase (FASN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [1044]
Selenium DM25CGV N. A. N. A. Approved [81]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [922]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [118]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [1045]
Quercetin DM3NC4M Obesity 5B81 Approved [670]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [95]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [271]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [197]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [1046]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [231]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [1047]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [668]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [307]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [488]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Presenilin-1 (PSEN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [117]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1048]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Menthol DMG2KW7 Back pain ME84.Z Approved [329]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [1033]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [319]
Bortezomib DMNO38U Leukemia Approved [331]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [268]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NADH dehydrogenase flavoprotein 1, mitochondrial (NDUFV1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [81]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [482]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
Paclitaxel DMLB81S Breast carcinoma Approved [1049]
Arsenic DMTL2Y1 N. A. N. A. Approved [1050]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [488]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [344]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glycogen synthase kinase-3 alpha (GSK3A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [81]
Quercetin DM3NC4M Obesity 5B81 Approved [1051]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [1052]
Methamphetamine DMPM4SK Anxiety Approved [1053]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [1054]
Tacrolimus DMZ7XNQ Graft-versus-host disease 4B24 Approved [1052]
Urethane DM7NSI0 N. A. N. A. Phase 4 [397]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [654]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [1051]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [81]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [117]
Gefitinib DM15F0X Colon adenocarcinoma Approved [1055]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1056]
Selenium DM25CGV N. A. N. A. Approved [81]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [780]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [1057]
Quercetin DM3NC4M Obesity 5B81 Approved [69]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [1058]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [440]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Type-2 angiotensin II receptor (AGTR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Menthol DMG2KW7 Back pain ME84.Z Approved [329]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [607]
Coprexa DMA0WEK Neurological disorder 6B60 Phase 3 [1059]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [88]
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Drug(s) Affected By Caveolin-2 (CAV2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [538]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [514]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [716]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [1060]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [238]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [1061]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [1062]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-5 (CASP5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [901]
Sanguinarine DMDINFS Dental plaque DA08.4 Approved [901]
Menthol DMG2KW7 Back pain ME84.Z Approved [329]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [30]
Paclitaxel DMLB81S Breast carcinoma Approved [1063]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [1064]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [241]
9-hydroxyoctadecadienoic acid DM0FWNJ Discovery agent N.A. Investigative [1065]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [1064]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Signal transducer and activator of transcription 2 (STAT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [687]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [1066]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [307]
Arsenic DMTL2Y1 N. A. N. A. Approved [882]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [422]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [373]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase PLK1 (PLK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [568]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [108]
Methotrexate DM2TEOL Anterior urethra cancer Approved [154]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [226]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1067]
Testosterone DM7HUNW Hot flushes GA30 Approved [199]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [199]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Death-associated protein kinase 1 (DAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [132]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [185]
Testosterone DM7HUNW Hot flushes GA30 Approved [199]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [200]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [1068]
Menthol DMG2KW7 Back pain ME84.Z Approved [329]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [880]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [1069]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By GTP-binding protein RAD (RRAD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [237]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [200]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Testosterone enanthate DMB6871 N. A. N. A. Approved [380]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [202]
Ethanol DMDRQZU Chronic pain MG30 Approved [1070]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [1071]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-7 (CASP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [210]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [106]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1072]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [1073]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [1074]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [1074]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [134]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [1075]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [1076]
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Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [1022]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [1077]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [727]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [1078]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [49]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [297]
Meloxicam DM2AR7L Arthritis FA20 Approved [1079]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [298]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [1080]
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Drug(s) Affected By Cadherin-8 (CDH8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [315]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [231]
Testosterone DM7HUNW Hot flushes GA30 Approved [143]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [1081]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [47]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [607]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [315]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [425]
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Drug(s) Affected By Cadherin-11 (CDH11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [132]
Selenium DM25CGV N. A. N. A. Approved [81]
Quercetin DM3NC4M Obesity 5B81 Approved [195]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [8]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [462]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [803]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
Paclitaxel DMLB81S Breast carcinoma Approved [348]
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Drug(s) Affected By BH3-interacting domain death agonist (BID)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [175]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [297]
Selenium DM25CGV N. A. N. A. Approved [367]
Quercetin DM3NC4M Obesity 5B81 Approved [69]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [95]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [185]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1082]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [1083]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [1084]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
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Drug(s) Affected By Interleukin-2 (IL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sirolimus DMGW1ID Advanced cancer 2A00-2F9Z Approved [32]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [519]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [218]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [1085]
Methotrexate DM2TEOL Anterior urethra cancer Approved [1086]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [1087]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [949]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [1088]
Fentanyl DM8WAHT Analgesia MB40.8 Approved [1089]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [1090]
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Drug(s) Affected By Eukaryotic initiation factor 4A-I (EIF4A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [354]
Methotrexate DM2TEOL Anterior urethra cancer Approved [111]
Quercetin DM3NC4M Obesity 5B81 Approved [172]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [1091]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [191]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Paclitaxel DMLB81S Breast carcinoma Approved [1092]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [299]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [164]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Synaptosomal-associated protein 25 (SNAP25)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [434]
Selenium DM25CGV N. A. N. A. Approved [81]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Panobinostat DM58WKG Chronic graft versus host disease Approved [315]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [191]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [1093]
Heroin diacetylmorphine DMDBWHY Neurological disorder 6B60 Approved [821]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [30]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [307]
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Drug(s) Affected By C-X-C chemokine receptor type 4 (CXCR4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [391]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Methotrexate DM2TEOL Anterior urethra cancer Approved [278]
Quercetin DM3NC4M Obesity 5B81 Approved [184]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [972]
Carfilzomib DM48K0X Multiple myeloma 2A83 Approved [1094]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [185]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [278]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1095]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [1096]
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Drug(s) Affected By Transforming growth factor beta-2 proprotein (TGFB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1097]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [95]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [1098]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1099]
Testosterone DM7HUNW Hot flushes GA30 Approved [199]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [1009]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [200]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [191]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [30]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PPP2CB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [108]
Methotrexate DM2TEOL Anterior urethra cancer Approved [111]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [95]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [128]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [1100]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [108]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [1101]
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Drug(s) Affected By Actin, aortic smooth muscle (ACTA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [948]
Quercetin DM3NC4M Obesity 5B81 Approved [1102]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Panobinostat DM58WKG Chronic graft versus host disease Approved [1103]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1104]
Pirfenidone DM6VZFQ Idiopathic pulmonary fibrosis CB03.4 Approved [1105]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [86]
Testosterone DM7HUNW Hot flushes GA30 Approved [199]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [1106]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [199]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone H3.1 (H3C1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Methotrexate DM2TEOL Anterior urethra cancer Approved [154]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [231]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [719]
Testosterone DM7HUNW Hot flushes GA30 Approved [199]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [199]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [191]
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Drug(s) Affected By Protein jagged-1 (JAG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Methotrexate DM2TEOL Anterior urethra cancer Approved [538]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [514]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [1107]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [315]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [1033]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [551]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [1108]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Menthol DMG2KW7 Back pain ME84.Z Approved [329]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [1033]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [1109]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [1110]
Arsenic DMTL2Y1 N. A. N. A. Approved [1111]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [584]
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Drug(s) Affected By Death domain-containing protein CRADD (CRADD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [391]
Quercetin DM3NC4M Obesity 5B81 Approved [125]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [488]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [373]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [1112]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [1113]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [401]
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Drug(s) Affected By Mothers against decapentaplegic homolog 3 (SMAD3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [401]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1114]
Quercetin DM3NC4M Obesity 5B81 Approved [1115]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [126]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1116]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [484]
Ethanol DMDRQZU Chronic pain MG30 Approved [371]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [30]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [1117]
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Drug(s) Affected By Serine/arginine-rich splicing factor 3 (SRSF3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [361]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [169]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [687]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [147]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [422]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [361]
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Drug(s) Affected By Mucin-5AC (MUC5AC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [391]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1118]
Selenium DM25CGV N. A. N. A. Approved [74]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [391]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [1119]
Capsaicin DMGMF6V Back pain ME84.Z Approved [1120]
Vitamin A DMJ2AH4 Night blindness 9D45 Approved [391]
Dihydroxyacetone DMM1LG2 Sunburn EJ40 Approved [1121]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [391]
Bleomycin DMNER5S Cervical cancer 2C77.0 Approved [1122]
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Drug(s) Affected By Cytochrome c (CYCS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [175]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [1123]
Gefitinib DM15F0X Colon adenocarcinoma Approved [703]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [1078]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [119]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [1073]
Methotrexate DM2TEOL Anterior urethra cancer Approved [26]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [1124]
Pefloxacin DM49IGF Gonococcal urethritis 1A70.0Y Approved [1125]
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Drug(s) Affected By 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 (PLCB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Testosterone DM7HUNW Hot flushes GA30 Approved [143]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [141]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [373]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [47]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [1126]
phorbol 12-myristate 13-acetate DMJWD62 Acute myeloid leukaemia 2A60 Phase 2 [1126]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [883]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [241]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [991]
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Drug(s) Affected By Insulinoma-associated protein 1 (INSM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [250]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [393]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [250]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [740]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [1127]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [241]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [202]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [317]
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Drug(s) Affected By Serine/arginine-rich splicing factor 2 (SRSF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [421]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [803]
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [455]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [1128]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [147]
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Drug(s) Affected By Transcription factor RelB (RELB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [1129]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [106]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Methotrexate DM2TEOL Anterior urethra cancer Approved [26]
Quercetin DM3NC4M Obesity 5B81 Approved [195]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [84]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [128]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [228]
Testosterone DM7HUNW Hot flushes GA30 Approved [199]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [199]
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Drug(s) Affected By AMP deaminase 3 (AMPD3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [81]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [236]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [422]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [47]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [88]
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Drug(s) Affected By POU domain, class 5, transcription factor 1 (POU5F1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [1130]
Quercetin DM3NC4M Obesity 5B81 Approved [1043]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1131]
Panobinostat DM58WKG Chronic graft versus host disease Approved [315]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [898]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1132]
Testosterone DM7HUNW Hot flushes GA30 Approved [1133]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [1093]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [1134]
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Drug(s) Affected By Collagen alpha-3(IV) chain (COL4A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [81]
Methotrexate DM2TEOL Anterior urethra cancer Approved [111]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [924]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [8]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [30]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [307]
Vandetanib DMRICNP Solid tumour/cancer 2A00-2F9Z Approved [1135]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [373]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [1136]
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Drug(s) Affected By Transcription factor p65 (RELA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [175]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [728]
Selenium DM25CGV N. A. N. A. Approved [81]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [1137]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [135]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [869]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [1138]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [361]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [1139]
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Drug(s) Affected By Copper-transporting ATPase 1 (ATP7A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [126]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Paclitaxel DMLB81S Breast carcinoma Approved [1140]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [1141]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [1142]
Mitoxantrone DMM39BF Acute myelogenous leukaemia 2A41 Approved [1143]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [1143]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [1143]
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Drug(s) Affected By Collagen alpha-1(XIV) chain (COL14A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [81]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [250]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [115]
Panobinostat DM58WKG Chronic graft versus host disease Approved [315]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [128]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [8]
Testosterone enanthate DMB6871 N. A. N. A. Approved [380]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Ethanol DMDRQZU Chronic pain MG30 Approved [173]
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Drug(s) Affected By Synaptic vesicular amine transporter (SLC18A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Norepinephrine DMOUC09 Alopecia ED70 Approved [1144]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [1144]
Methamphetamine DMPM4SK Anxiety Approved [1145]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [1146]
Haloperidol DM96SE0 Delirium Approved [1146]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Dextroamphetamine DMMIHVP Attention deficit hyperactivity disorder 6A05.Z Approved [1146]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [1147]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [1148]
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Drug(s) Affected By Peroxiredoxin-1 (PRDX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1149]
Etretinate DM2CZFA Keratosis ED56 Approved [109]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [95]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [54]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [113]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [128]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [168]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [113]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [1047]
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Drug(s) Affected By Tumor necrosis factor receptor superfamily member 9 (TNFRSF9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [391]
Methotrexate DM2TEOL Anterior urethra cancer Approved [26]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1150]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [1151]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [765]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [202]
Menthol DMG2KW7 Back pain ME84.Z Approved [329]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [880]
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Drug(s) Affected By Tight junction protein ZO-1 (TJP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [479]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [132]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [86]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [492]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Ethanol DMDRQZU Chronic pain MG30 Approved [1152]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [1153]
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Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [722]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [291]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Verapamil DMA7PEW Angina pectoris BA40 Approved [726]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [391]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [1078]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [159]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [132]
Meloxicam DM2AR7L Arthritis FA20 Approved [1154]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [162]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [589]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1155]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [297]
Selenium DM25CGV N. A. N. A. Approved [81]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [1156]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [176]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [1157]
Quercetin DM3NC4M Obesity 5B81 Approved [69]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [54]
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Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [528]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [391]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [431]
Methotrexate DM2TEOL Anterior urethra cancer Approved [215]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [1158]
Quercetin DM3NC4M Obesity 5B81 Approved [184]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [55]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [391]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [1159]
Ethacrynic acid DM60QMR Edema MG29 Approved [1160]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/arginine-rich splicing factor 1 (SRSF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [110]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Selenium DM25CGV N. A. N. A. Approved [81]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Folic Acid DMEMBJC Colorectal carcinoma Approved [450]
Bortezomib DMNO38U Leukemia Approved [331]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/arginine-rich splicing factor 4 (SRSF4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [514]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [514]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [1047]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [492]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [1161]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [1162]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [991]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [421]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [421]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein phosphatase 3 catalytic subunit alpha (PPP3CA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1014]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [794]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [200]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Benzatropine DMF7EXL Parkinsonian disorder Approved [103]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [30]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [822]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [422]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Leukocyte surface antigen CD47 (CD47)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [175]
Methotrexate DM2TEOL Anterior urethra cancer Approved [26]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [822]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [141]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By TNF receptor-associated factor 2 (TRAF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [1163]
Quercetin DM3NC4M Obesity 5B81 Approved [69]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [95]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Ceritinib DMB920Z Non-small-cell lung cancer 2C25.Y Approved [1164]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Menthol DMG2KW7 Back pain ME84.Z Approved [329]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [880]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [307]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Vesicle transport protein SEC20 (BNIP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [492]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [488]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [715]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [715]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [1165]
Camptothecin DM6CHNJ Solid tumour/cancer 2A00-2F9Z Phase 3 [715]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [1165]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [426]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [132]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [358]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [84]
Quinolones DM5GVHU Bacterial infection 1A00-1C4Z Approved [1166]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [403]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [168]
Testosterone DM7HUNW Hot flushes GA30 Approved [143]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [242]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Baculoviral IAP repeat-containing protein 1 (NAIP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Menthol DMG2KW7 Back pain ME84.Z Approved [329]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [880]
Bortezomib DMNO38U Leukemia Approved [1167]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [1168]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [1169]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [373]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [1170]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By TNF receptor-associated factor 3 (TRAF3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [26]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Menthol DMG2KW7 Back pain ME84.Z Approved [329]
Capsaicin DMGMF6V Back pain ME84.Z Approved [383]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [880]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [1171]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Hydroxychloroquine DMSIVND Chronic renal failure GB61.Z Approved [1172]
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Drug(s) Affected By TAR DNA-binding protein 43 (TARDBP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [1173]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [86]
Doxycycline DM7ICNU Acne vulgaris ED80 Approved [1174]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Sorbitol DMAN0DE Constipation DD91.1 Approved [1175]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [1176]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
Hexachlorophene DMLKSE0 Bacterial infection 1A00-1C4Z Approved [1177]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By FAS-associated death domain protein (FADD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Selenium DM25CGV N. A. N. A. Approved [1178]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [134]
Quercetin DM3NC4M Obesity 5B81 Approved [49]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [95]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [84]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1179]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [168]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [86]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [328]
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Drug(s) Affected By DnaJ homolog subfamily C member 3 (DNAJC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [115]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [84]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [733]
Testosterone DM7HUNW Hot flushes GA30 Approved [143]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [200]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [718]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [1180]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/arginine-rich splicing factor 5 (SRSF5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1181]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1182]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [169]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Benzatropine DMF7EXL Parkinsonian disorder Approved [103]
Clozapine DMFC71L Schizophrenia 6A20 Approved [103]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [307]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/arginine-rich splicing factor 6 (SRSF6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [312]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Testosterone enanthate DMB6871 N. A. N. A. Approved [380]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Ethanol DMDRQZU Chronic pain MG30 Approved [734]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [803]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Indomethacin DMSC4A7 Bursitis Approved [1183]
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Drug(s) Affected By Bcl-2-interacting killer (BIK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1184]
Methotrexate DM2TEOL Anterior urethra cancer Approved [847]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [351]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [900]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [901]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Clozapine DMFC71L Schizophrenia 6A20 Approved [1185]
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Drug(s) Affected By Rho-associated protein kinase 1 (ROCK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [892]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1186]
Testosterone DM7HUNW Hot flushes GA30 Approved [143]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [1187]
Pamidronate DMB4AVP Bone Paget disease Approved [1188]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [1189]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 3 (BIRC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [1190]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [291]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [401]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [297]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [95]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [185]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [673]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [187]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [1191]
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Drug(s) Affected By Baculoviral IAP repeat-containing protein 2 (BIRC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [1190]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [291]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [1157]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1014]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [389]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [898]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1192]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [1191]
Etodolac DM6WJO9 Osteoarthritis FA00-FA05 Approved [1193]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [1194]
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Drug(s) Affected By Sequestosome-1 (SQSTM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [516]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [831]
Gefitinib DM15F0X Colon adenocarcinoma Approved [1195]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [80]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [1196]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [194]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [514]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cullin-1 (CUL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [106]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [361]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [508]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Bortezomib DMNO38U Leukemia Approved [881]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [422]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [361]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [1197]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apoptosis-stimulating of p53 protein 2 (TP53BP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [195]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [492]
Menthol DMG2KW7 Back pain ME84.Z Approved [329]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [422]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [28]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [489]
Urethane DM7NSI0 N. A. N. A. Phase 4 [397]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [1198]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [1199]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [398]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [297]
Methotrexate DM2TEOL Anterior urethra cancer Approved [1200]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [339]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [469]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [55]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [113]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [84]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Calcyphosin (CAPS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [346]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [803]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [644]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [373]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [345]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [241]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Kelch-like ECH-associated protein 1 (KEAP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [1201]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [398]
Selenium DM25CGV N. A. N. A. Approved [81]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [514]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [189]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [242]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [242]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [242]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [1047]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [378]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Beclin-1 (BECN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcipotriol DM03CP7 Psoriasis EA90 Approved [1202]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1016]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [464]
Fluoxetine DM3PD2C Bipolar depression Approved [1203]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1204]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1205]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [1206]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [735]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Metal regulatory transcription factor 1 (MTF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [492]
Gallium nitrate DMF9O6B Hypercalcaemia 5B91.0 Approved [859]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [1066]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [1110]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [373]
Busulfan DMXYJ9C Chronic myelogenous leukaemia 2A20.0 Approved [1066]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1207]
Urethane DM7NSI0 N. A. N. A. Phase 4 [397]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [1208]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Eukaryotic translation initiation factor 4H (EIF4H)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [1209]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [47]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [1210]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [241]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [421]
D-glucose DMMG2TO Discovery agent N.A. Investigative [354]
chloropicrin DMSGBQA Discovery agent N.A. Investigative [1211]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Neutrophil cytosol factor 4 (NCF4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [26]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Bortezomib DMNO38U Leukemia Approved [331]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [883]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [418]
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Drug(s) Affected By Mitochondrial import receptor subunit TOM20 homolog (TOMM20)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [268]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [47]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [492]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [1212]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [421]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [1213]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Methotrexate DM2TEOL Anterior urethra cancer Approved [111]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [1163]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [226]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [168]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Menthol DMG2KW7 Back pain ME84.Z Approved [329]
Hesperidin DMI5DW1 Vascular purpura 3B60 Approved [1214]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ELAV-like protein 1 (ELAVL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [185]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [465]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [1215]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [454]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Flurbiprofen DMGN4BY Osteoarthritis FA00-FA05 Approved [1215]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [1216]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [740]
Amsacrine DMZKYIV Acute lymphoblastic leukaemia 2A85 Approved [1217]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitochondrial import receptor subunit TOM34 (TOMM34)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [103]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [492]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Benzatropine DMF7EXL Parkinsonian disorder Approved [103]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [268]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [241]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [451]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mothers against decapentaplegic homolog 2 (SMAD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [80]
Quercetin DM3NC4M Obesity 5B81 Approved [1115]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [361]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [1218]
Panobinostat DM58WKG Chronic graft versus host disease Approved [315]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [363]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [192]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [192]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Insulin-like growth factor-binding protein 7 (IGFBP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [90]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [185]
Panobinostat DM58WKG Chronic graft versus host disease Approved [315]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [716]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [658]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Folic Acid DMEMBJC Colorectal carcinoma Approved [450]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [551]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl-2-related protein A1 (BCL2A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1219]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [278]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [619]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [914]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [202]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [865]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [880]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [278]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [1071]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-17A (IL17A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [26]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [625]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [208]
Paroxetine DM5PVQE Anxiety disorder 6B00-6B0Z Approved [1220]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1221]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [1222]
Ethanol DMDRQZU Chronic pain MG30 Approved [702]
Arsenic DMTL2Y1 N. A. N. A. Approved [1223]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [1224]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [1225]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [1226]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [132]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [1227]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [1228]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [185]
Levamisole DM5EN79 Parasitic infection 1D0Y-1G2Z Approved [1229]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1230]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [1231]
Promethazine DM6I5GR Hyperemesis gravidarum Approved [466]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Occludin (OCLN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1232]
Methotrexate DM2TEOL Anterior urethra cancer Approved [48]
Quercetin DM3NC4M Obesity 5B81 Approved [1233]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1234]
Testosterone DM7HUNW Hot flushes GA30 Approved [143]
Thioguanine DM7NKEV Acute lymphocytic leukaemia 2B33.3 Approved [1235]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [236]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Ethanol DMDRQZU Chronic pain MG30 Approved [1152]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Survival motor neuron protein (SMN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amikacin DM5PDRB Bacteremia 1A73 Approved [1236]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [1236]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [803]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [141]
Arsenic DMTL2Y1 N. A. N. A. Approved [412]
Tobramycin DMUI0CH Bacteremia 1A73 Approved [1236]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [584]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [1169]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By kinase isozyme 4, mitochondrial (PDK4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [195]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [1237]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1238]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [1239]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [242]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [242]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [242]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Testosterone enanthate DMB6871 N. A. N. A. Approved [380]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [1240]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1241]
Prednisone DM2HG4X Acute asthma CA23 Approved [1242]
Triamterene DM2HU9I Congestive heart failure BD10 Approved [1242]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [1243]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [1244]
Epinephrine DM3KJBC Acute asthma CA23 Approved [1245]
Quercetin DM3NC4M Obesity 5B81 Approved [184]
Fluoxetine DM3PD2C Bipolar depression Approved [234]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [834]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Kynureninase (KYNU)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [640]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [446]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [226]
Estrone DM5T6US Acne vulgaris ED80 Approved [640]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [393]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [86]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [202]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dual oxidase maturation factor 1 (DUOXA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [1246]
Milchsaure DM462BT Pruritus EC90 Investigative [435]
Drug(s) Affected By Interferon-induced protein 44-like (IFI44L)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [278]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [278]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [237]
Testosterone DM7HUNW Hot flushes GA30 Approved [143]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [687]
Testosterone enanthate DMB6871 N. A. N. A. Approved [380]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [315]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [202]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mesoderm-specific transcript homolog protein (MEST)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Folic Acid DMEMBJC Colorectal carcinoma Approved [1247]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [238]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [307]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [147]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [488]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [47]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Long-chain fatty acid transport protein 3 (SLC27A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [27]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [238]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [307]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [740]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [47]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Doublesex- and mab-3-related transcription factor A1 (DMRTA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [307]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [373]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [1161]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [241]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [991]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [317]
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Drug(s) Affected By C-type lectin domain family 6 member A (CLEC6A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Drug(s) Affected By Histone H2A type 2-A (H2AC18)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [361]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [719]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [30]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [1248]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [164]
Arsenic DMTL2Y1 N. A. N. A. Approved [412]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By MFS-type transporter SLC18B1 (SLC18B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Panobinostat DM58WKG Chronic graft versus host disease Approved [315]
Testosterone DM7HUNW Hot flushes GA30 Approved [199]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [199]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proline/serine-rich coiled-coil protein 1 (PSRC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [719]
Testosterone DM7HUNW Hot flushes GA30 Approved [199]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [199]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [492]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [1249]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [331]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Disheveled-associated activator of morphogenesis 2 (DAAM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [315]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [238]
Arsenic DMTL2Y1 N. A. N. A. Approved [1050]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [488]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [88]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [81]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [241]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [991]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Adiponectin receptor protein 2 (ADIPOR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [26]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [1250]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [147]
Arsenic DMTL2Y1 N. A. N. A. Approved [412]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [1062]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [617]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [1251]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By F-box only protein 11 (FBXO11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [81]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [404]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [307]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [164]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [473]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [1252]
Josamycin DMKJ8LB Bacterial infection 1A00-1C4Z Approved [483]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By E3 ubiquitin-protein ligase DTX1 (DTX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1253]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [492]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [607]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [241]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [401]
acetaldehyde DMJFKG4 Discovery agent N.A. Investigative [1254]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By CREB3 regulatory factor (CREBRF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [228]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [733]
Testosterone DM7HUNW Hot flushes GA30 Approved [143]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [202]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [803]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pulmonary surfactant-associated protein A1 (SFTPA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [662]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [665]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [241]
Drug(s) Affected By Ral-GDS-related protein (RGL4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [141]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [1255]
Drug(s) Affected By Ankyrin repeat domain-containing protein 36B (ANKRD36B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [191]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [317]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [422]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [1256]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [88]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [1257]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [1258]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [317]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mixed lineage kinase domain-like protein (MLKL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [95]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [97]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1259]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ethanol DMDRQZU Chronic pain MG30 Approved [1260]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [336]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [668]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Estradiol 17-beta-dehydrogenase 11 (HSD17B11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [185]
Testosterone DM7HUNW Hot flushes GA30 Approved [199]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [199]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [164]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [422]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [111]
Quercetin DM3NC4M Obesity 5B81 Approved [464]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [97]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1261]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [237]
Ceritinib DMB920Z Non-small-cell lung cancer 2C25.Y Approved [1164]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Cholecalciferol DMGU74E Adult acute monocytic leukemia Approved [1262]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [1263]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Endonuclease 8-like 3 (NEIL3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [568]
Methotrexate DM2TEOL Anterior urethra cancer Approved [154]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Testosterone DM7HUNW Hot flushes GA30 Approved [199]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [199]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [202]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [141]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DEP domain-containing mTOR-interacting protein (DEPTOR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [401]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Panobinostat DM58WKG Chronic graft versus host disease Approved [315]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [1264]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [30]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [551]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [238]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nucleolar complex protein 3 homolog (NOC3L)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [434]
Selenium DM25CGV N. A. N. A. Approved [81]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [185]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [373]
Topotecan DMP6G8T Central nervous system neoplasm Approved [809]
Urethane DM7NSI0 N. A. N. A. Phase 4 [397]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pleckstrin homology-like domain family A member 1 (PHLDA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [185]
Panobinostat DM58WKG Chronic graft versus host disease Approved [315]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [128]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [237]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [191]
Testosterone enanthate DMB6871 N. A. N. A. Approved [380]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Secretogranin-3 (SCG3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Panobinostat DM58WKG Chronic graft versus host disease Approved [315]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [88]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [607]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [88]
PDX-101 DM6OC53 Plasma cell myeloma 2A83.1 Phase 2 [315]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [418]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [317]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By C-type lectin domain family 4 member D (CLEC4D)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [1265]
Arsenic DMTL2Y1 N. A. N. A. Approved [412]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [241]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [401]
Sulforaphane DMQY3L0 Skin disease EA00-EM0Z Investigative [1266]
⏷ Show the Full List of 6 Drug(s)
Drug(s) Affected By Cortactin-binding protein 2 (CTTNBP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [165]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [191]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [1267]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [307]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [1246]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [1258]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [241]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [991]
PMID27336223-Compound-5 DM6E50A N. A. N. A. Patented [1267]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA damage-binding protein 2 (DDB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1268]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [86]
Testosterone DM7HUNW Hot flushes GA30 Approved [199]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [199]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [242]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [242]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [640]
Quercetin DM3NC4M Obesity 5B81 Approved [388]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [185]
Estrone DM5T6US Acne vulgaris ED80 Approved [640]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [236]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Mestranol DMG3F94 Contraception QA21 Approved [640]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [640]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear receptor subfamily 4 group A member 3 (NR4A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [32]
Methotrexate DM2TEOL Anterior urethra cancer Approved [278]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [185]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [278]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [404]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [238]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [278]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [1071]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ER degradation-enhancing alpha-mannosidase-like protein 1 (EDEM1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [491]
Nilotinib DM7HXWT Chronic myelogenous leukaemia 2A20.0 Approved [491]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [1269]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [492]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [1270]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [241]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CREB-binding protein (CREBBP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [81]
Quercetin DM3NC4M Obesity 5B81 Approved [911]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1271]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [194]
Testosterone DM7HUNW Hot flushes GA30 Approved [1272]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [484]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [1033]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [1100]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [476]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-10 (CASP10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [401]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [434]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [297]
Methotrexate DM2TEOL Anterior urethra cancer Approved [111]
Quercetin DM3NC4M Obesity 5B81 Approved [1273]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [95]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [54]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1274]
Testosterone DM7HUNW Hot flushes GA30 Approved [143]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neurogenin-1 (NEUROG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1275]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [191]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [1276]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [493]
Arsenic DMTL2Y1 N. A. N. A. Approved [412]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [740]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [1276]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [241]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [401]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Paclitaxel DMLB81S Breast carcinoma Approved [1277]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [291]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [175]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [1278]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [1279]
Quercetin DM3NC4M Obesity 5B81 Approved [1280]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [95]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1281]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [364]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 25 (TNFRSF25)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [393]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [364]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [168]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Menthol DMG2KW7 Back pain ME84.Z Approved [329]
Capsaicin DMGMF6V Back pain ME84.Z Approved [383]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone H2B type 1-H (H2BC9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [154]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [115]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [231]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [551]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [164]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [422]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Adiponectin receptor protein 1 (ADIPOR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [26]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [1282]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [1283]
Arsenic DMTL2Y1 N. A. N. A. Approved [1284]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [1285]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [1286]
Urethane DM7NSI0 N. A. N. A. Phase 4 [397]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [241]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [202]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By SOSS complex subunit B2 (NABP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Panobinostat DM58WKG Chronic graft versus host disease Approved [315]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [86]
Testosterone DM7HUNW Hot flushes GA30 Approved [143]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [191]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [202]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interferon-stimulated gene 20 kDa protein (ISG20)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [278]
Aripiprazole DM3NUMH Bipolar I disorder Approved [553]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [278]
Testosterone DM7HUNW Hot flushes GA30 Approved [199]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [199]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [336]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [278]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hepatitis A virus cellular receptor 1 (HAVCR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [1287]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [1288]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [820]
Gentamicin DMKINJO Bacteremia 1A73 Approved [1289]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [1290]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [1291]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [164]
Arsenic DMTL2Y1 N. A. N. A. Approved [474]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [584]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein arginine N-methyltransferase 6 (PRMT6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [1292]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [1293]
Arsenic DMTL2Y1 N. A. N. A. Approved [412]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [373]
Urethane DM7NSI0 N. A. N. A. Phase 4 [397]
Berberine DMC5Q8X N. A. N. A. Phase 4 [1294]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [297]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [194]
Methotrexate DM2TEOL Anterior urethra cancer Approved [1200]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [1295]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [358]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [55]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [1296]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [901]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [390]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATPase family AAA domain-containing protein 5 (ATAD5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Testosterone DM7HUNW Hot flushes GA30 Approved [199]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [199]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [551]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [740]
PEITC DMOMN31 Prostate cancer 2C82.0 Phase 2 [1297]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [1258]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bile acid receptor (NR1H4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [398]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [1298]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [1299]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1300]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [97]
Nisoldipine DM7ISKJ Hypertension BA00-BA04 Approved [1298]
Cholic Acid DM7OKQV Cholelithiasis DC11 Approved [1299]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [1301]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tribbles homolog 3 (TRIB3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [336]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [346]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [673]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [84]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [613]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [673]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [237]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [228]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [86]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cysteine/serine-rich nuclear protein 1 (CSRNP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [86]
Testosterone DM7HUNW Hot flushes GA30 Approved [199]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [199]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [594]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [476]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Selenocysteine insertion sequence-binding protein 2 (SECISBP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [191]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [356]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [372]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [372]
Arsenic DMTL2Y1 N. A. N. A. Approved [412]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [740]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [489]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1207]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [241]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Granulocyte colony-stimulating factor receptor (CSF3R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [26]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [558]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [404]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [236]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [141]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [740]
Famotidine DMRL3AB Gastric ulcer DA60 Approved [32]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Parkinson disease protein 7 (PARK7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1302]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [1303]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [492]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Menthol DMG2KW7 Back pain ME84.Z Approved [329]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [301]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [268]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [808]
Sodium phenylbutyrate DMXLBCQ Spinal muscular atrophy 8B61 Approved [1304]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [1305]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Collagen alpha-1(XII) chain (COL12A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [191]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [238]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [1110]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [307]
Arsenic DMTL2Y1 N. A. N. A. Approved [1306]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [584]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [1307]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aconitate hydratase, mitochondrial (ACO2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [81]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [807]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [1308]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [164]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [268]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [1309]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [47]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Calcium and integrin-binding protein 1 (CIB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [401]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [185]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [136]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [86]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [307]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [1310]
Capecitabine DMTS85L Adenocarcinoma 2D40 Approved [1311]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [1212]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [991]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myeloid differentiation primary response protein MyD88 (MYD88)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [175]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [670]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [361]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [84]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [84]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone H2B type 1-N (H2BC15)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [1110]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [307]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [164]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [584]
Berberine DMC5Q8X N. A. N. A. Phase 4 [1294]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [1257]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [991]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [369]
Deguelin DMXT7WG Esophageal squamous cell carcinoma 2E60.1 Investigative [375]
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Drug(s) Affected By Histone H2B type 1-M (H2BC14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [401]
Methotrexate DM2TEOL Anterior urethra cancer Approved [111]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [393]
Ethanol DMDRQZU Chronic pain MG30 Approved [371]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [551]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [1110]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [740]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [373]
Lucanthone DMZLBUO Solid tumour/cancer 2A00-2F9Z Approved [720]
Berberine DMC5Q8X N. A. N. A. Phase 4 [1294]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By BAG family molecular chaperone regulator 1 (BAG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [81]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [237]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [1194]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [492]
Menthol DMG2KW7 Back pain ME84.Z Approved [329]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [880]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [319]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [1312]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proton-coupled zinc antiporter SLC30A2 (SLC30A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [1313]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [584]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [47]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [607]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [1314]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [241]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [991]
Forskolin DM6ITNG Solid tumour/cancer 2A00-2F9Z Investigative [1315]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proline-rich protein 15-like protein (PRR15L)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [30]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [307]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [345]
Urethane DM7NSI0 N. A. N. A. Phase 4 [397]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [766]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [241]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [673]
Panobinostat DM58WKG Chronic graft versus host disease Approved [315]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1316]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [1264]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [105]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [718]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [1316]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Racecadotril DMFOTZ7 Diarrhea ME05.1 Approved [1317]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By TNF receptor-associated factor 4 (TRAF4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [81]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [168]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [200]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Ethanol DMDRQZU Chronic pain MG30 Approved [734]
Folic Acid DMEMBJC Colorectal carcinoma Approved [318]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Nuclear pore complex protein Nup85 (NUP85)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [147]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [422]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [990]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [421]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [369]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase recruitment domain-containing protein 6 (CARD6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [346]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [86]
Testosterone DM7HUNW Hot flushes GA30 Approved [199]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [199]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Menthol DMG2KW7 Back pain ME84.Z Approved [329]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [422]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [28]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase PINK1, mitochondrial (PINK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [338]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1318]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [200]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [1318]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Ethanol DMDRQZU Chronic pain MG30 Approved [407]
Capsaicin DMGMF6V Back pain ME84.Z Approved [1319]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [1320]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [1321]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-type lectin domain family 7 member A (CLEC7A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [226]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [716]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [787]
Bortezomib DMNO38U Leukemia Approved [331]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [307]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [740]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [241]
Beta-D-Glucose DM5IHYP Discovery agent N.A. Investigative [1322]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [1323]
Butanoic Acid DMTAJP7 Discovery agent N.A. Investigative [1324]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Eukaryotic translation initiation factor 2A (EIF2A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [152]
Quercetin DM3NC4M Obesity 5B81 Approved [421]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [361]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [1325]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1326]
Cerulenin DM6N4PR Weight loss MG43.5 Approved [1327]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [169]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [328]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sulfiredoxin-1 (SRXN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [244]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [185]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [208]
Ethacrynic acid DM60QMR Edema MG29 Approved [1328]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [673]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [242]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [242]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tripartite motif-containing protein 2 (TRIM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [401]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [194]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [200]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [164]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [831]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1016]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1329]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [97]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [1330]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [457]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [458]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [459]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Autophagy protein 5 (ATG5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Gefitinib DM15F0X Colon adenocarcinoma Approved [463]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1329]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [457]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [458]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [1206]
Promethazine DM6I5GR Hyperemesis gravidarum Approved [466]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [1331]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [722]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [88]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3A (MAP1LC3A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1332]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1333]
Trovafloxacin DM6AN32 Acute gonococcal cervicitis Approved [458]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [1334]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Capsaicin DMGMF6V Back pain ME84.Z Approved [1319]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
Chloroquine DMSI5CB Malaria 1F40-1F45 Approved [1335]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Polyamine-transporting ATPase 13A3 (ATP13A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [361]
Testosterone DM7HUNW Hot flushes GA30 Approved [143]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [422]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [345]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [88]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [489]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [361]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [421]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By 5'-nucleotidase domain-containing protein 2 (NT5DC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Selenium DM25CGV N. A. N. A. Approved [81]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [740]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [28]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RecQ-mediated genome instability protein 1 (RMI1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Testosterone DM7HUNW Hot flushes GA30 Approved [199]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [199]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [740]
Urethane DM7NSI0 N. A. N. A. Phase 4 [397]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [421]
THAPSIGARGIN DMDMQIE N. A. N. A. Preclinical [451]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Claspin (CLSPN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [111]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [231]
Testosterone DM7HUNW Hot flushes GA30 Approved [199]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [199]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [202]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [803]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [551]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [141]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [740]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Calcyclin-binding protein (CACYBP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [156]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [317]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [356]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [147]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Kinetochore protein Spc25 (SPC25)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [154]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [231]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [86]
Testosterone DM7HUNW Hot flushes GA30 Approved [199]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [199]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [718]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase Sgk2 (SGK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [398]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [336]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [115]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [1336]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [1068]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [336]
Ampicillin DMHWE7P Acute epiglottitis Approved [78]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [307]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl-2-like protein 10 (BCL2L10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Menthol DMG2KW7 Back pain ME84.Z Approved [329]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [880]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [429]
acetaldehyde DMJFKG4 Discovery agent N.A. Investigative [1254]
Drug(s) Affected By ATP-binding cassette sub-family B member 6 (ABCB6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [27]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [242]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [242]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [30]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Solute carrier family 40 member 1 (SLC40A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [377]
Panobinostat DM58WKG Chronic graft versus host disease Approved [315]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [619]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Folic Acid DMEMBJC Colorectal carcinoma Approved [1337]
Gallium nitrate DMF9O6B Hypercalcaemia 5B91.0 Approved [859]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [30]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Carbohydrate-responsive element-binding protein (MLXIPL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [238]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [372]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [307]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [584]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [8]
Urethane DM7NSI0 N. A. N. A. Phase 4 [397]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [315]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NADPH oxidase 4 (NOX4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [757]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [465]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [379]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Capsaicin DMGMF6V Back pain ME84.Z Approved [1338]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [336]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [264]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [820]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [1339]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Exosome complex component RRP46 (EXOSC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [185]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [492]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [462]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [372]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [372]
Arsenic DMTL2Y1 N. A. N. A. Approved [412]
Urethane DM7NSI0 N. A. N. A. Phase 4 [397]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Growth/differentiation factor 3 (GDF3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1131]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [492]
Folic Acid DMEMBJC Colorectal carcinoma Approved [450]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [372]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [372]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [584]
Chlorothiazide DMLHESP Chronic heart failure BD1Z Approved [1340]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [241]
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Drug(s) Affected By Diablo IAP-binding mitochondrial protein (DIABLO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [79]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [434]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [297]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [339]
Quercetin DM3NC4M Obesity 5B81 Approved [184]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [1341]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [1083]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [86]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [492]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Toll-like receptor 9 (TLR9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Chloroquine DMSI5CB Malaria 1F40-1F45 Approved [1342]
Hydroxychloroquine DMSIVND Chronic renal failure GB61.Z Approved [1343]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [1255]
Drug(s) Affected By Dual oxidase 2 (DUOX2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [392]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [128]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [428]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [740]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [88]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [241]
D-glucose DMMG2TO Discovery agent N.A. Investigative [955]
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Drug(s) Affected By Dual oxidase 1 (DUOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [81]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [226]
Testosterone DM7HUNW Hot flushes GA30 Approved [199]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [199]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [1344]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [1345]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [418]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [1346]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [1323]
D-glucose DMMG2TO Discovery agent N.A. Investigative [955]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ras association domain-containing protein 1 (RASSF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [81]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1347]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [86]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [492]
Folic Acid DMEMBJC Colorectal carcinoma Approved [1348]
Procainamide DMNMXR8 Ventricular arrhythmias BC71 Approved [1349]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [1350]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [141]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Beta-catenin-interacting protein 1 (CTNNBIP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [803]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [307]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [854]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [315]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [1113]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [421]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone chaperone ASF1B (ASF1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [154]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [226]
Testosterone DM7HUNW Hot flushes GA30 Approved [199]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [199]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [718]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [1249]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [594]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [47]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [1270]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [88]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [28]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [991]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [369]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA damage-inducible transcript 4 protein (DDIT4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [80]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [163]
Methotrexate DM2TEOL Anterior urethra cancer Approved [538]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [1351]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [84]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [136]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [719]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bcl-2-associated transcription factor 1 (BCLAF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Selenium DM25CGV N. A. N. A. Approved [81]
Quercetin DM3NC4M Obesity 5B81 Approved [421]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [361]
Testosterone enanthate DMB6871 N. A. N. A. Approved [380]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [378]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [202]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Ethanol DMDRQZU Chronic pain MG30 Approved [734]
Capsaicin DMGMF6V Back pain ME84.Z Approved [383]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [436]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [106]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [118]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [118]
Quercetin DM3NC4M Obesity 5B81 Approved [1352]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [118]
Pyrazinamide DM4IF32 Meningeal tuberculosis Approved [439]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [440]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [792]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bifunctional apoptosis regulator (BFAR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [128]
Folic Acid DMEMBJC Colorectal carcinoma Approved [318]
Menthol DMG2KW7 Back pain ME84.Z Approved [329]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [47]
EMODIN DMAEDQG Coronavirus Disease 2019 (COVID-19) 1D6Y Terminated [1353]
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Drug(s) Affected By DNA (DNMT3B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [872]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1354]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [876]
Testosterone DM7HUNW Hot flushes GA30 Approved [199]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [199]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [492]
Ethanol DMDRQZU Chronic pain MG30 Approved [1355]
Folic Acid DMEMBJC Colorectal carcinoma Approved [450]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [1124]
Fructose DM43AN2 Vomiting MD90 Approved [360]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [1356]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [1357]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [128]
Ketotifen DM74XKS Allergic conjunctivitis 9A60.02 Approved [1358]
Riboflavin DM8YMWE Acne vulgaris ED80 Approved [1359]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [1359]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DnaJ homolog subfamily B member 9 (DNAJB9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [185]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [97]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [228]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [105]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [242]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [242]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [718]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [317]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [242]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [81]
Methotrexate DM2TEOL Anterior urethra cancer Approved [26]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Testosterone DM7HUNW Hot flushes GA30 Approved [199]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [199]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [687]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [30]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lipid transferase CIDEB (CIDEB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [336]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1360]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Folic Acid DMEMBJC Colorectal carcinoma Approved [318]
Menthol DMG2KW7 Back pain ME84.Z Approved [329]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [336]
Bortezomib DMNO38U Leukemia Approved [349]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [1361]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Frizzled-4 (FZD4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [346]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [462]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [238]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [299]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ras-related protein Rab-26 (RAB26)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Testosterone DM7HUNW Hot flushes GA30 Approved [143]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [242]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [242]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [242]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [803]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [307]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor MafF (MAFF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [244]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [64]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [1362]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [95]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [115]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [97]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apelin (APLN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [26]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [129]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [1363]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [607]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [1314]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [241]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [1363]
⏷ Show the Full List of 8 Drug(s)
Drug(s) Affected By Apoptosis-associated speck-like protein containing a CARD (PYCARD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [175]
Selenium DM25CGV N. A. N. A. Approved [81]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Panobinostat DM58WKG Chronic graft versus host disease Approved [315]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [901]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [189]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Ethanol DMDRQZU Chronic pain MG30 Approved [776]
Menthol DMG2KW7 Back pain ME84.Z Approved [329]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein-arginine deiminase type-4 (PADI4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [1364]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [373]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [1365]
DNCB DMDTVYC Immune System disease 4A01-4B41 Phase 2 [1197]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [241]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [1366]
Sulforaphane DMQY3L0 Skin disease EA00-EM0Z Investigative [1266]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [244]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [65]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [446]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [65]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [65]
Methotrexate DM2TEOL Anterior urethra cancer Approved [278]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [1367]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Fluoxetine DM3PD2C Bipolar depression Approved [673]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [65]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA polymerase eta (POLH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [446]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [733]
Leflunomide DMR8ONJ Arthritis FA20 Approved [171]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [78]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [202]
Lomustine DMMWSUL Brain cancer 2A00 Approved [1368]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [1368]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase recruitment domain-containing protein 8 (CARD8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [175]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Menthol DMG2KW7 Back pain ME84.Z Approved [329]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [331]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [488]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [47]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [241]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By TNF receptor-associated factor 6 (TRAF6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [388]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [194]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [1369]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Folic Acid DMEMBJC Colorectal carcinoma Approved [318]
Menthol DMG2KW7 Back pain ME84.Z Approved [329]
Arsenic DMTL2Y1 N. A. N. A. Approved [1370]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [1371]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phosphoserine aminotransferase (PSAT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [80]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [226]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [619]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [105]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [242]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [242]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [355]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA (DNMT3A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [870]
Methotrexate DM2TEOL Anterior urethra cancer Approved [111]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [872]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1354]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [876]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [1134]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [191]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [29]
Ethanol DMDRQZU Chronic pain MG30 Approved [1355]
Folic Acid DMEMBJC Colorectal carcinoma Approved [1372]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NF-kappa-B essential modulator (IKBKG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1373]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [227]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [187]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Menthol DMG2KW7 Back pain ME84.Z Approved [329]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [1374]
Chloroquine DMSI5CB Malaria 1F40-1F45 Approved [1374]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lymphocyte antigen 96 (LY96)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [175]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [80]
Methotrexate DM2TEOL Anterior urethra cancer Approved [26]
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [336]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [231]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [237]
Testosterone DM7HUNW Hot flushes GA30 Approved [199]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [199]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Superoxide dismutase (SOD1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [1375]
Haloperidol DM96SE0 Delirium Approved [32]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [391]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [157]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [71]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [1376]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [1377]
Methotrexate DM2TEOL Anterior urethra cancer Approved [48]
Epinephrine DM3KJBC Acute asthma CA23 Approved [279]
Quercetin DM3NC4M Obesity 5B81 Approved [1378]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Sodium-dependent dopamine transporter (SLC6A3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [1379]
Amphetamine DMSZQAK Attention deficit hyperactivity disorder 6A05.Z Approved [1380]
Bupropion DM5PCS7 Depression 6A70-6A7Z Approved [1381]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [1382]
Testosterone DM7HUNW Hot flushes GA30 Approved [199]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [199]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Dextroamphetamine DMMIHVP Attention deficit hyperactivity disorder 6A05.Z Approved [1383]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [88]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [1384]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DNA repair nuclease/redox regulator APEX1 (APEX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [183]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [1385]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [356]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [141]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [1386]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [1252]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [47]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Breast cancer type 1 susceptibility protein (BRCA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [67]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [842]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [183]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [1137]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [125]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [124]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [166]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [361]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [128]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Solute carrier family 45 member 4 (SLC45A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [191]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Folic Acid DMEMBJC Colorectal carcinoma Approved [450]
Arsenic DMTL2Y1 N. A. N. A. Approved [412]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [1387]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [1388]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [401]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [1389]
3-iodothyronamine DM3L0F8 Discovery agent N.A. Investigative [1390]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By Heat shock 70 kDa protein 1-like (HSPA1L)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [104]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [209]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [54]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [55]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Isoproterenol DMK7MEY Atrioventricular block Approved [756]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Teriflunomide DMQ2FKJ Hyperlipidaemia 5C80 Approved [1391]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By DnaJ homolog subfamily B member 1 (DNAJB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [116]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Gefitinib DM15F0X Colon adenocarcinoma Approved [107]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [673]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [84]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [97]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [168]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [228]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [169]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hereditary hemochromatosis protein (HFE)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [237]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [687]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [351]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [488]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [423]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [88]
Torcetrapib DMDHYM7 Hyperlipidaemia 5C80 Discontinued in Phase 2 [1392]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [1393]
cinnamaldehyde DMZDUXG Discovery agent N.A. Investigative [1394]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NAD-dependent protein deacylase sirtuin-6 (SIRT6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1395]
Testosterone DM7HUNW Hot flushes GA30 Approved [143]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [1339]
Paclitaxel DMLB81S Breast carcinoma Approved [1396]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [1397]
SEN-196 DMLDBQ5 Huntington disease 8A01.10 Phase 2 [1398]
TAK-715 DMZKPI8 Rheumatoid arthritis FA20 Phase 2 [1399]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [1161]
NORCANTHARIDIN DM9B6Y1 Discovery agent N.A. Investigative [1396]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Ribosyldihydronicotinamide dehydrogenase (NQO2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [78]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [115]
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [1400]
Panobinostat DM58WKG Chronic graft versus host disease Approved [315]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [1401]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [137]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Hesperetin DMKER83 High blood cholesterol level 5C80.00 Approved [1385]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Solute carrier family 22 member 2 (SLC22A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [1402]
Cimetidine DMH61ZB Acid-reflux disorder DA22 Approved [1403]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [1403]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [1404]
Lamivudine DMI347A Chronic HBV infection 1E51.0Z Approved [1405]
Famotidine DMRL3AB Gastric ulcer DA60 Approved [1404]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [1406]
Trospium chloride DM32XZT Discovery agent N.A. Approved [1407]
Phenoxybenzamine DM8KSQH Malignant essential hypertension BA00 Approved [1408]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [492]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By N-glycosylase/DNA lyase (OGG1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1409]
Selenium DM25CGV N. A. N. A. Approved [699]
Quercetin DM3NC4M Obesity 5B81 Approved [1409]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [361]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [128]
Ethanol DMDRQZU Chronic pain MG30 Approved [1410]
Folic Acid DMEMBJC Colorectal carcinoma Approved [1411]
Paclitaxel DMLB81S Breast carcinoma Approved [1092]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [1412]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [398]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aladin (AAAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [47]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [1161]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [991]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [401]
COUMESTROL DM40TBU Discovery agent N.A. Investigative [357]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By Huntingtin (HTT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [1413]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Menthol DMG2KW7 Back pain ME84.Z Approved [329]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [141]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [1258]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [1161]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [1199]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [421]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [421]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Polyamine-transporting ATPase 13A2 (ATP13A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [488]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [47]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1414]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [1415]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [991]
MG-132 DMKA2YS N. A. N. A. Preclinical [1414]
Milchsaure DM462BT Pruritus EC90 Investigative [435]
Sulforaphane DMQY3L0 Skin disease EA00-EM0Z Investigative [1266]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [627]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [70]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Clozapine DMFC71L Schizophrenia 6A20 Approved [103]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [30]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [307]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [488]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [47]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [1212]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Trastuzumab DMZQOUX Breast cancer 2C60-2C65 Approved [32]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [1129]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [1416]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [1417]
Gefitinib DM15F0X Colon adenocarcinoma Approved [1418]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [132]
Selenium DM25CGV N. A. N. A. Approved [81]
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [911]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Alpha-synuclein (SNCA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [83]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [128]
Testosterone enanthate DMB6871 N. A. N. A. Approved [380]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [454]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [803]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
Bortezomib DMNO38U Leukemia Approved [881]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [1419]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [372]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glutathione S-transferase theta-1 (GSTT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [1420]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [95]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [128]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [299]
Arsenic DMTL2Y1 N. A. N. A. Approved [412]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [488]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [1209]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [345]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Homeobox protein Hox-B13 (HOXB13)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [191]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [1081]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [307]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [488]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1421]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [241]
geraniol DMS3CBD Discovery agent N.A. Investigative [1422]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [164]
Methotrexate DM2TEOL Anterior urethra cancer Approved [111]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [361]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [1423]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [462]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [319]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [147]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Acylamino-acid-releasing enzyme (APEH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [81]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [28]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [138]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [139]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [422]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [47]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [406]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [492]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By High affinity copper uptake protein 1 (SLC31A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [229]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [1424]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [1424]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [185]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [115]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [1425]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [101]
TRIENTINE DMD2WPG Inborn error of metabolism 5C50-5C59 Approved [1424]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Paclitaxel DMLB81S Breast carcinoma Approved [1140]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Selenoprotein H (SELENOH)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [1426]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [492]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [102]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [373]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [47]
Urethane DM7NSI0 N. A. N. A. Phase 4 [397]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [241]
Sulforaphane DMQY3L0 Skin disease EA00-EM0Z Investigative [1427]
⏷ Show the Full List of 8 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Multidrug and toxin extrusion protein 1 (SLC47A1) DTZGT0P S47A1_HUMAN Substrate [2]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [3]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 (PLCB2) OTPAHDGO PLCB2_HUMAN Post-Translational Modifications [4]
10 kDa heat shock protein, mitochondrial (HSPE1) OT7JSZLB CH10_HUMAN Gene/Protein Processing [5]
5'-nucleotidase domain-containing protein 2 (NT5DC2) OTPDRGGN NT5D2_HUMAN Gene/Protein Processing [6]
60 kDa heat shock protein, mitochondrial (HSPD1) OTTO1Y11 CH60_HUMAN Gene/Protein Processing [5]
72 kDa type IV collagenase (MMP2) OT5NIWA2 MMP2_HUMAN Gene/Protein Processing [7]
A disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAMTS2) OTTK22NO ATS2_HUMAN Gene/Protein Processing [8]
Aconitate hydratase, mitochondrial (ACO2) OTF2UVNV ACON_HUMAN Gene/Protein Processing [9]
Actin, aortic smooth muscle (ACTA2) OTEDLG8E ACTA_HUMAN Gene/Protein Processing [7]
Actin, cytoplasmic 1 (ACTB) OT1MCP2F ACTB_HUMAN Gene/Protein Processing [5]
Activator of apoptosis harakiri (HRK) OTR4GWJ0 HRK_HUMAN Gene/Protein Processing [10]

References

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3 Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
4 Suppression of ROS generation by 4,4-diaminodiphenylsulfone in non-phagocytic human diploid fibroblasts. Exp Mol Med. 2010 Mar 31;42(3):223-32. doi: 10.3858/emm.2010.42.3.024.
5 Cytotoxicity and gene array analysis of alveolar epithelial A549 cells exposed to paraquat. Chem Biol Interact. 2010 Dec 5;188(3):427-36.
6 An in vitro strategy using multiple human induced pluripotent stem cell-derived models to assess the toxicity of chemicals: A case study on paraquat. Toxicol In Vitro. 2022 Jun;81:105333. doi: 10.1016/j.tiv.2022.105333. Epub 2022 Feb 16.
7 Long noncoding RNA HOTAIR functions as ceRNA to regulate MMP2 in paraquat induced lung epithelial-mesenchymal transition. Toxicology. 2021 Sep;461:152891. doi: 10.1016/j.tox.2021.152891. Epub 2021 Aug 6.
8 Primary Human Hepatocyte Spheroids as Tools to Study the Hepatotoxic Potential of Non-Pharmaceutical Chemicals. Int J Mol Sci. 2021 Oct 12;22(20):11005. doi: 10.3390/ijms222011005.
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19 Molecular mechanism of renal tubular secretion of the antimalarial drug chloroquine. Antimicrob Agents Chemother. 2011 Jul;55(7):3091-8.
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21 Abemaciclib Inhibits Renal Tubular Secretion Without Changing Glomerular Filtration Rate. Clin Pharmacol Ther. 2019 May;105(5):1187-1195.
22 FDA Drug Development and Drug Interactions
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32 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
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38 Some non-sensitizers upregulate CD54 expression by activation of the NLRP3 inflammasome in THP-1 cells. J Toxicol Sci. 2019;44(3):213-224. doi: 10.2131/jts.44.213.
39 Dimethyl Fumarate Inhibits the Nuclear Factor B Pathway in Breast Cancer Cells by Covalent Modification of p65 Protein. J Biol Chem. 2016 Feb 12;291(7):3639-47. doi: 10.1074/jbc.M115.679704. Epub 2015 Dec 18.
40 Increased organophosphate scavenging in a butyrylcholinesterase mutant. Chem Biol Interact. 2008 Sep 25;175(1-3):376-9. doi: 10.1016/j.cbi.2008.04.012. Epub 2008 Apr 22.
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797 Hydroquinone Exposure Worsens Rheumatoid Arthritis through the Activation of the Aryl Hydrocarbon Receptor and Interleukin-17 Pathways. Antioxidants (Basel). 2021 Jun 7;10(6):929. doi: 10.3390/antiox10060929.
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844 Resveratrol attenuates senescence of adipose-derived mesenchymal stem cells and restores their paracrine effects on promoting insulin secretion of INS-1 cells through Pim-1. Eur Rev Med Pharmacol Sci. 2016;20(6):1203-13.
845 Ribavirin augments doxorubicin's efficacy in human hepatocellular carcinoma through inhibiting doxorubicin-induced eIF4E activation. J Biochem Mol Toxicol. 2018 Jan;32(1). doi: 10.1002/jbt.22007. Epub 2017 Nov 7.
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855 Effects of tobacco compounds on gene expression in fetal lung fibroblasts. Environ Toxicol. 2008 Aug;23(4):423-34.
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873 Cyclophosphamide perturbs cytosine methylation in Jurkat-T cells through LSD1-mediated stabilization of DNMT1 protein. Chem Res Toxicol. 2011 Nov 21;24(11):2040-3. doi: 10.1021/tx2003849. Epub 2011 Nov 1.
874 DNA methyltransferase inhibitors coordinately induce expression of the human reelin and glutamic acid decarboxylase 67 genes. Mol Pharmacol. 2007 Mar;71(3):644-53. doi: 10.1124/mol.106.030635. Epub 2006 Oct 25.
875 Arsenic trioxide inhibits DNA methyltransferase and restores methylation-silenced genes in human liver cancer cells. Hum Pathol. 2006 Mar;37(3):298-311.
876 Hypomethylation mediated by decreased DNMTs involves in the activation of proto-oncogene MPL in TK6 cells treated with hydroquinone. Toxicol Lett. 2012 Mar 25;209(3):239-45. doi: 10.1016/j.toxlet.2011.12.020. Epub 2012 Jan 8.
877 Exposure-based assessment of chemical teratogenicity using morphogenetic aggregates of human embryonic stem cells. Reprod Toxicol. 2020 Jan;91:74-91. doi: 10.1016/j.reprotox.2019.10.004. Epub 2019 Nov 8.
878 hiPSC-Based Model of Prenatal Exposure to Cannabinoids: Effect on Neuronal Differentiation. Front Mol Neurosci. 2020 Jul 6;13:119. doi: 10.3389/fnmol.2020.00119. eCollection 2020.
879 Epigenetic changes and disturbed neural development in a human embryonic stem cell-based model relating to the fetal valproate syndrome. Hum Mol Genet. 2012 Sep 15;21(18):4104-14. doi: 10.1093/hmg/dds239. Epub 2012 Jun 20.
880 Effect of zoledronic acid on oral fibroblasts and epithelial cells: a potential mechanism of bisphosphonate-associated osteonecrosis. Br J Haematol. 2009 Mar;144(5):667-76. doi: 10.1111/j.1365-2141.2008.07504.x. Epub 2008 Nov 20.
881 Induction of heme oxygenase-1 by cobalt protoporphyrin enhances the antitumour effect of bortezomib in adult T-cell leukaemia cells. Br J Cancer. 2007 Oct 22;97(8):1099-105. doi: 10.1038/sj.bjc.6604003. Epub 2007 Sep 25.
882 Transcriptomics and methylomics of CD4-positive T cells in arsenic-exposed women. Arch Toxicol. 2017 May;91(5):2067-2078. doi: 10.1007/s00204-016-1879-4. Epub 2016 Nov 12.
883 Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells. J Biol Chem. 2012 Dec 14;287(51):43137-55.
884 Treatment with anticancer agents induces dysregulation of specific Wnt signaling pathways in human ovarian luteinized granulosa cells in vitro. Toxicol Sci. 2013 Nov;136(1):183-92. doi: 10.1093/toxsci/kft175. Epub 2013 Aug 16.
885 Progesterone increases csk homologous kinase in HMC-1560 human mast cells and reduces cell proliferation. J Cell Biochem. 2007 Dec 1;102(5):1271-80. doi: 10.1002/jcb.21357.
886 Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2. Int J Cancer. 2006 Mar 15;118(6):1370-80. doi: 10.1002/ijc.21537.
887 Estrogen and pure antiestrogen fulvestrant (ICI 182 780) augment cell-matrigel adhesion of MCF-7 breast cancer cells through a novel G protein coupled estrogen receptor (GPR30)-to-calpain signaling axis. Toxicol Appl Pharmacol. 2014 Mar 1;275(2):176-81. doi: 10.1016/j.taap.2014.01.005. Epub 2014 Jan 17.
888 Inhibition of activator protein 1 by barbiturates is mediated by differential effects on mitogen-activated protein kinases and the small G proteins ras and rac-1. J Pharmacol Exp Ther. 2004 Dec;311(3):1232-40. doi: 10.1124/jpet.104.071332. Epub 2004 Jul 19.
889 Growth of hormone-dependent MCF-7 breast cancer cells is promoted by constitutive caveolin-1 whose expression is lost in an EGF-R-mediated manner during development of tamoxifen resistance. Breast Cancer Res Treat. 2010 Feb;119(3):575-91. doi: 10.1007/s10549-009-0355-8. Epub 2009 Mar 15.
890 Effect of histamine H1 receptor antagonists on TARC/CCL17 and MDC/CCL22 production from CD14+ cells induced by antigenic stimulation in vitro. Int Arch Allergy Immunol. 2011;155(1):38-51. doi: 10.1159/000318720. Epub 2010 Nov 25.
891 SIRT3 Mediates the Antioxidant Effect of Hydrogen Sulfide in Endothelial Cells. Antioxid Redox Signal. 2016 Feb 20;24(6):329-43. doi: 10.1089/ars.2015.6331. Epub 2015 Nov 10.
892 Protein expression profiling identifies molecular targets of quercetin as a major dietary flavonoid in human colon cancer cells. Proteomics. 2004 Jul;4(7):2160-74.
893 Comparative study of the neurotoxicological effects of tramadol and tapentadol in SH-SY5Y cells. Toxicology. 2016 Jun 1;359-360:1-10. doi: 10.1016/j.tox.2016.06.010. Epub 2016 Jun 15.
894 Downregulation of mitogen-activated protein kinases (MAPKs) in chronic ethanol-induced fatty liver. Toxicol Mech Methods. 2020 Jul;30(6):407-416. doi: 10.1080/15376516.2020.1747126. Epub 2020 Apr 1.
895 A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16657-62. doi: 10.1073/pnas.0707936104. Epub 2007 Oct 9.
896 The stent-eluting drugs sirolimus and paclitaxel suppress healing of the endothelium by induction of autophagy. Am J Pathol. 2009 Nov;175(5):2226-34.
897 Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids. J Biol Chem. 2005 Sep 9;280(36):31498-507. doi: 10.1074/jbc.M505537200. Epub 2005 Jul 13.
898 The antipsychotic chlorpromazine suppresses YAP signaling, stemness properties, and drug resistance in breast cancer cells. Chem Biol Interact. 2019 Apr 1;302:28-35. doi: 10.1016/j.cbi.2019.01.033. Epub 2019 Jan 28.
899 Cannabidiol Protects Human Skin Keratinocytes from Hydrogen-Peroxide-Induced Oxidative Stress via Modulation of the Caspase-1-IL-1 Axis. J Nat Prod. 2021 May 28;84(5):1563-1572. doi: 10.1021/acs.jnatprod.1c00083. Epub 2021 May 6.
900 Comparative gene expression analysis of a chronic myelogenous leukemia cell line resistant to cyclophosphamide using oligonucleotide arrays and response to tyrosine kinase inhibitors. Leuk Res. 2007 Nov;31(11):1511-20.
901 Improved apoptotic cell death in drug-resistant non-small-cell lung cancer cells by tumor necrosis factor-related apoptosis-inducing ligand-based treatment. J Pharmacol Exp Ther. 2014 Mar;348(3):360-71. doi: 10.1124/jpet.113.210054. Epub 2013 Dec 17.
902 Variants of peroxiredoxins expression in response to hydroperoxide stress. Free Radic Biol Med. 2001 Mar 15;30(6):625-35. doi: 10.1016/s0891-5849(00)00503-7.
903 Protein profile in neuroblastoma cells incubated with S- and R-enantiomers of ibuprofen by iTRAQ-coupled 2-D LC-MS/MS analysis: possible action of induced proteins on Alzheimer's disease. Proteomics. 2008 Apr;8(8):1595-607. doi: 10.1002/pmic.200700556.
904 A comparative proteomic analysis for capsaicin-induced apoptosis between human hepatocarcinoma (HepG2) and human neuroblastoma (SK-N-SH) cells. Proteomics. 2008 Nov;8(22):4748-67. doi: 10.1002/pmic.200800094.
905 Ornithine decarboxylase antizyme upregulates DNA-dependent protein kinase and enhances the nonhomologous end-joining repair of DNA double-strand breaks in human oral cancer cells. Biochemistry. 2007 Aug 7;46(31):8920-32. doi: 10.1021/bi7000328. Epub 2007 Jul 14.
906 Quercetin induces the expression of peroxiredoxins 3 and 5 via the Nrf2/NRF1 transcription pathway. Invest Ophthalmol Vis Sci. 2011 Feb 22;52(2):1055-63. doi: 10.1167/iovs.10-5777.
907 Antineoplastic effects of decitabine, an inhibitor of DNA promoter methylation, in adrenocortical carcinoma cells. Arch Surg. 2010 Mar;145(3):226-32. doi: 10.1001/archsurg.2009.292.
908 Downregulation of the c-MYC target gene, peroxiredoxin III, contributes to arsenic trioxide-induced apoptosis in acute promyelocytic leukemia. Int J Cancer. 2009 Jul 15;125(2):264-75. doi: 10.1002/ijc.24341.
909 Mitochondrial proteomics investigation of a cellular model of impaired dopamine homeostasis, an early step in Parkinson's disease pathogenesis. Mol Biosyst. 2014 Jun;10(6):1332-44.
910 Proteomic profile of aminoglutethimide-induced apoptosis in HL-60 cells: role of myeloperoxidase and arylamine free radicals. Chem Biol Interact. 2015 Sep 5;239:129-38.
911 Inhibition of prostate cancer cell colony formation by the flavonoid quercetin correlates with modulation of specific regulatory genes. Clin Diagn Lab Immunol. 2004 Jan;11(1):63-9. doi: 10.1128/cdli.11.1.63-69.2004.
912 Peroxisome proliferator-activated receptor ligands affect growth-related gene expression in human leukemic cells. J Pharmacol Exp Ther. 2003 Jun;305(3):932-42. doi: 10.1124/jpet.103.049098. Epub 2003 Mar 20.
913 Retinoid targeting of different D-type cyclins through distinct chemopreventive mechanisms. Cancer Res. 2005 Jul 15;65(14):6476-83. doi: 10.1158/0008-5472.CAN-05-0370.
914 1,25-Dihydroxyvitamin D3 suppresses gene expression of eukaryotic translation initiation factor 2 in human promyelocytic leukemia HL-60 cells. Cell Struct Funct. 2005;30(1):1-6. doi: 10.1247/csf.30.1.
915 The combination of EGCG with warfarin reduces deep vein thrombosis in rabbits through modulating HIF-1 and VEGF via the PI3K/AKT and ERK1/2 signaling pathways. Chin J Nat Med. 2022 Sep;20(9):679-690. doi: 10.1016/S1875-5364(22)60172-9.
916 Angiotensin II type 1 receptor expression in polymorphonuclear leukocytes from high-risk subjects: changes after treatment with simvastatin. J Cardiovasc Pharmacol. 2007 May;49(5):299-305. doi: 10.1097/FJC.0b013e31803d35ce.
917 Using a customized DNA microarray for expression profiling of the estrogen-responsive genes to evaluate estrogen activity among natural estrogens and industrial chemicals. Environ Health Perspect. 2004 May;112(7):773-81. doi: 10.1289/ehp.6753.
918 Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine in bladder cancer cells. Oncogene. 2016 Aug 25;35(34):4518-28. doi: 10.1038/onc.2015.511. Epub 2016 Feb 8.
919 Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent. Mol Cancer. 2010 Aug 20;9:220.
920 Dihydromyricetin suppresses tumor growth via downregulation of the EGFR/Akt/survivin signaling pathway. J Biochem Mol Toxicol. 2023 Jun;37(6):e23328. doi: 10.1002/jbt.23328. Epub 2023 Feb 19.
921 Effect of toll-like receptor 7 and 9 targeted therapy to prevent the development of hepatocellular carcinoma. Liver Int. 2015 Mar;35(3):1063-76. doi: 10.1111/liv.12626. Epub 2014 Jul 30.
922 Low-expressional IGF1 mediated methimazole-induced liver developmental toxicity in fetal mice. Toxicology. 2018 Sep 1;408:70-79. doi: 10.1016/j.tox.2018.07.004. Epub 2018 Jul 7.
923 Characterization of antioxidant properties of natural killer-enhancing factor-B and induction of its expression by hydrogen peroxide. Toxicol Appl Pharmacol. 1997 Nov;147(1):135-42. doi: 10.1006/taap.1997.8270.
924 Cannabis-induced cytotoxicity in leukemic cell lines: the role of the cannabinoid receptors and the MAPK pathway. Blood. 2005 Feb 1;105(3):1214-21. doi: 10.1182/blood-2004-03-1182. Epub 2004 Sep 28.
925 9-cis-Retinoic acid (9cRA), a retinoid X receptor (RXR) ligand, exerts immunosuppressive effects on dendritic cells by RXR-dependent activation: inhibition of peroxisome proliferator-activated receptor gamma blocks some of the 9cRA activities, and precludes them to mature phenotype development. J Immunol. 2007 May 15;178(10):6130-9. doi: 10.4049/jimmunol.178.10.6130.
926 THP-1 monocytes but not macrophages as a potential alternative for CD34+ dendritic cells to identify chemical skin sensitizers. Toxicol Appl Pharmacol. 2009 Apr 15;236(2):221-30.
927 Melanoma Expressed-CD70 Is Regulated by RhoA and MAPK Pathways without Affecting Vemurafenib Treatment Activity. PLoS One. 2016 Feb 1;11(2):e0148095. doi: 10.1371/journal.pone.0148095. eCollection 2016.
928 Expression of CD30 mRNA, CD30L mRNA and a variant form of CD30 mRNA in restimulated peripheral blood mononuclear cells (PBMC) of patients with helminthic infections resembling a Th2 disease. Clin Exp Immunol. 1999 Jan;115(1):114-9. doi: 10.1046/j.1365-2249.1999.00774.x.
929 Inhibition of neuroblastoma proliferation by PF-3758309, a small-molecule inhibitor that targets p21-activated kinase 4. Oncol Rep. 2017 Nov;38(5):2705-2716. doi: 10.3892/or.2017.5989. Epub 2017 Sep 22.
930 Characterization of multidrug transporter-mediated efflux of avermectins in human and mouse neuroblastoma cell lines. Toxicol Lett. 2015 Jun 15;235(3):189-98. doi: 10.1016/j.toxlet.2015.04.005. Epub 2015 Apr 9.
931 Folate concentration dependent transport activity of the Multidrug Resistance Protein 1 (ABCC1). Biochem Pharmacol. 2004 Apr 15;67(8):1541-8.
932 Methotrexate normalizes up-regulated folate pathway genes in rheumatoid arthritis. Arthritis Rheum. 2013 Nov;65(11):2791-802.
933 Influence of redox-active compounds and PXR-activators on human MRP1 and MRP2 gene expression. Toxicology. 2002 Feb 28;171(2-3):137-46.
934 Enhanced in vitro invasiveness and drug resistance with altered gene expression patterns in a human lung carcinoma cell line after pulse selection with anticancer drugs. Int J Cancer. 2004 Sep 10;111(4):484-93. doi: 10.1002/ijc.20230.
935 Co-encapsulation of chrysophsin-1 and epirubicin in PEGylated liposomes circumvents multidrug resistance in HeLa cells. Chem Biol Interact. 2015 Dec 5;242:13-23. doi: 10.1016/j.cbi.2015.08.023. Epub 2015 Sep 1.
936 Upregulation of multi drug resistance genes in doxorubicin resistant human acute myelogeneous leukemia cells and reversal of the resistance. Hematology. 2007 Dec;12(6):511-7. doi: 10.1080/10245330701562535.
937 Functional analysis of MRP1 cloned from bovine. FEBS Lett. 2002 Jun 19;521(1-3):211-3. doi: 10.1016/s0014-5793(02)02816-8.
938 Casodex treatment induces hypoxia-related gene expression in the LNCaP prostate cancer progression model. BMC Urol. 2005 Mar 24;5:5.
939 CDK4/6 inhibition provides a potent adjunct to Her2-targeted therapies in preclinical breast cancer models. Genes Cancer. 2014 Jul;5(7-8):261-72. doi: 10.18632/genesandcancer.24.
940 Expression of cytochrome P450 epoxygenases and soluble epoxide hydrolase is regulated by hypolipidemic drugs in dose-dependent manner. Toxicol Appl Pharmacol. 2018 Sep 15;355:156-163.
941 Sulindac suppresses beta-catenin expression in human cancer cells. Eur J Pharmacol. 2008 Mar 31;583(1):26-31. doi: 10.1016/j.ejphar.2007.12.034. Epub 2008 Feb 5.
942 Arsenic trioxide and 2-methoxyestradiol reduce beta-catenin accumulation after proteasome inhibition and enhance the sensitivity of myeloma cells to Bortezomib. Leuk Res. 2008 Nov;32(11):1674-83. doi: 10.1016/j.leukres.2008.03.039. Epub 2008 May 15.
943 Effect of aspirin on the Wnt/beta-catenin pathway is mediated via protein phosphatase 2A. Oncogene. 2006 Oct 19;25(49):6447-56. doi: 10.1038/sj.onc.1209658. Epub 2006 Jul 31.
944 Benzene metabolite hydroquinone induces apoptosis of bone marrow mononuclear cells through inhibition of -catenin signaling. Toxicol In Vitro. 2018 Feb;46:361-369. doi: 10.1016/j.tiv.2017.08.018. Epub 2017 Sep 5.
945 Anti-androgen 2-hydroxyflutamide modulates cadherin, catenin and androgen receptor phosphorylation in androgen-sensitive LNCaP and androgen-independent PC3 prostate cancer cell lines acting via PI3K/Akt and MAPK/ERK1/2 pathways. Toxicol In Vitro. 2017 Apr;40:324-335. doi: 10.1016/j.tiv.2017.01.019. Epub 2017 Feb 2.
946 Benzyl isothiocyanate attenuates the hydrogen peroxide-induced interleukin-13 expression through glutathione S-transferase P induction in T lymphocytic leukemia cells. J Biochem Mol Toxicol. 2018 Jun;32(6):e22054.
947 Alterations in eotaxin, monocyte chemoattractant protein-4, interleukin-5, and interleukin-13 after systemic steroid treatment for nasal polyps. Otolaryngol Head Neck Surg. 2004 Nov;131(5):585-9. doi: 10.1016/j.otohns.2004.05.028.
948 Editor's Highlight: Modeling Compound-Induced Fibrogenesis In Vitro Using Three-Dimensional Bioprinted Human Liver Tissues. Toxicol Sci. 2016 Dec;154(2):354-367. doi: 10.1093/toxsci/kfw169. Epub 2016 Sep 7.
949 Direct and indirect effects of retinoic acid on human Th2 cytokine and chemokine expression by human T lymphocytes. BMC Immunol. 2006 Nov 21;7:27. doi: 10.1186/1471-2172-7-27.
950 Detection of Drug-Responsive T-Lymphocytes in a Case of Fatal Antituberculosis Drug-Related Liver Injury. Chem Res Toxicol. 2016 Nov 21;29(11):1793-1795. doi: 10.1021/acs.chemrestox.6b00393. Epub 2016 Nov 9.
951 Inhibition of interleukin-13 gene expression in T cells through GATA-3 pathway by arsenic trioxide. Chin Med J (Engl). 2008 Nov 20;121(22):2346-9.
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953 Molecular characterization of a toxicological tipping point during human stem cell differentiation. Reprod Toxicol. 2020 Jan;91:1-13. doi: 10.1016/j.reprotox.2019.10.001. Epub 2019 Oct 7.
954 Environmental pollutant induced cellular injury is reflected in exosomes from placental explants. Placenta. 2020 Jan 1;89:42-49. doi: 10.1016/j.placenta.2019.10.008. Epub 2019 Oct 17.
955 Imbalance in the antioxidant defence system and pro-genotoxic status induced by high glucose concentrations: In vitro testing in human liver cells. Toxicol In Vitro. 2020 Dec;69:105001. doi: 10.1016/j.tiv.2020.105001. Epub 2020 Sep 15.
956 The in vitro pharmacology of the peripherally restricted opioid receptor antagonists, alvimopan, ADL 08-0011 and methylnaltrexone. Naunyn Schmiedebergs Arch Pharmacol. 2007 May;375(3):205-20. doi: 10.1007/s00210-007-0146-x. Epub 2007 Mar 6.
957 A G protein-biased ligand at the ?-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine. J Pharmacol Exp Ther. 2013 Mar;344(3):708-17.
958 Association of ABCB1/MDR1 and OPRM1 gene polymorphisms with morphine pain relief. Clin Pharmacol Ther. 2008 Apr;83(4):559-66.
959 The effect of mitragynine on cAMP formation and mRNA expression of mu-opioid receptors mediated by chronic morphine treatment in SK-N-SH neuroblastoma cell. J Ethnopharmacol. 2013 Jun 21;148(1):135-43. doi: 10.1016/j.jep.2013.03.078. Epub 2013 Apr 19.
960 In vitro functional characterization of a panel of non-fentanyl opioid new psychoactive substances. Arch Toxicol. 2020 Nov;94(11):3819-3830. doi: 10.1007/s00204-020-02855-7. Epub 2020 Jul 31.
961 Cannabinoid receptor type 2 agonists induce transcription of the mu-opioid receptor gene in Jurkat T cells. Mol Pharmacol. 2006 Apr;69(4):1486-91. doi: 10.1124/mol.105.018325. Epub 2006 Jan 24.
962 Regulation of opioid and cannabinoid receptor genes in human neuroblastoma and T cells by the epigenetic modifiers trichostatin A and 5-aza-2'-deoxycytidine. Neuroimmunomodulation. 2012;19(3):180-6. doi: 10.1159/000331474. Epub 2012 Jan 18.
963 Interplay between cellular methyl metabolism and adaptive efflux during oncogenic transformation from chronic arsenic exposure in human cells. J Biol Chem. 2008 Jul 11;283(28):19342-50.
964 All-trans-retinoic acid intensifies endoplasmic reticulum stress in N-acetylglucosaminyltransferase V repressed human hepatocarcinoma cells by perturbing homocysteine metabolism. J Cell Biochem. 2010 Feb 15;109(3):468-77.
965 Copper-transporting P-type adenosine triphosphatase (ATP7B) is associated with cisplatin resistance. Cancer Res. 2000 Mar 1;60(5):1312-6.
966 The loop connecting metal-binding domains 3 and 4 of ATP7B is a target of a kinase-mediated phosphorylation. Biochemistry. 2009 Jun 23;48(24):5573-81. doi: 10.1021/bi900325k.
967 Oxidative stress modulates expression of immune checkpoint genes via activation of AhR signaling. Toxicol Appl Pharmacol. 2022 Dec 15;457:116314. doi: 10.1016/j.taap.2022.116314. Epub 2022 Nov 9.
968 Profiling of enantiopure drugs towards aryl hydrocarbon (AhR), glucocorticoid (GR) and pregnane X (PXR) receptors in human reporter cell lines. Chem Biol Interact. 2014 Feb 5;208:64-76. doi: 10.1016/j.cbi.2013.11.018. Epub 2013 Dec 6.
969 Involvement of cytoskeleton in AhR-dependent CYP1A1 expression. Curr Drug Metab. 2006 Apr;7(3):301-13. doi: 10.2174/138920006776359310.
970 Sulindac and its metabolites induce carcinogen metabolizing enzymes in human colon cancer cells. Int J Cancer. 2008 Mar 1;122(5):990-8.
971 Quercetin, quercetin glycosides and taxifolin differ in their ability to induce AhR activation and CYP1A1 expression in HepG2 cells. Phytother Res. 2012 Nov;26(11):1746-52.
972 Omeprazole inhibits pancreatic cancer cell invasion through a nongenomic aryl hydrocarbon receptor pathway. Chem Res Toxicol. 2015 May 18;28(5):907-18.
973 Induction of paraoxonase 1 and apolipoprotein A-I gene expression by aspirin. J Lipid Res. 2008 Oct;49(10):2142-8.
974 N-acylation of glucosamine modulates chondrocyte growth, proteoglycan synthesis, and gene expression. J Rheumatol. 2005 Sep;32(9):1775-86.
975 Novel stabilin-1 interacting chitinase-like protein (SI-CLP) is up-regulated in alternatively activated macrophages and secreted via lysosomal pathway. Blood. 2006 Apr 15;107(8):3221-8. doi: 10.1182/blood-2005-07-2843. Epub 2005 Dec 15.
976 Wnt signaling pathway is epigenetically regulated by methylation of Wnt antagonists in acute myeloid leukemia. Leukemia. 2009 Sep;23(9):1658-66. doi: 10.1038/leu.2009.86. Epub 2009 Apr 23.
977 Comprehensive analysis of transcriptomic changes induced by low and high doses of bisphenol A in HepG2 spheroids in vitro and rat liver in vivo. Environ Res. 2019 Jun;173:124-134. doi: 10.1016/j.envres.2019.03.035. Epub 2019 Mar 18.
978 ST1926, a novel and orally active retinoid-related molecule inducing apoptosis in myeloid leukemia cells: modulation of intracellular calcium homeostasis. Blood. 2004 Jan 1;103(1):194-207.
979 Estrogen regulation of apoptosis in osteoblasts. Physiol Behav. 2010 Feb 9;99(2):181-5. doi: 10.1016/j.physbeh.2009.04.025. Epub 2009 May 5.
980 Controlled diesel exhaust and allergen coexposure modulates microRNA and gene expression in humans: Effects on inflammatory lung markers. J Allergy Clin Immunol. 2016 Dec;138(6):1690-1700. doi: 10.1016/j.jaci.2016.02.038. Epub 2016 Apr 24.
981 Fumarate hydratase inactivation in hereditary leiomyomatosis and renal cell cancer is synthetic lethal with ferroptosis induction. Cancer Sci. 2018 Sep;109(9):2757-2766. doi: 10.1111/cas.13701. Epub 2018 Jul 20.
982 Chronic cyclophosphamide exposure alters the profile of rat sperm nuclear matrix proteins. Biol Reprod. 2007 Aug;77(2):303-11. doi: 10.1095/biolreprod.107.060244. Epub 2007 May 2.
983 Trabectedin induces ferroptosis via regulation of HIF-1/IRP1/TFR1 and Keap1/Nrf2/GPX4 axis in non-small cell lung cancer cells. Chem Biol Interact. 2023 Jan 5;369:110262. doi: 10.1016/j.cbi.2022.110262. Epub 2022 Nov 14.
984 The effect of quercetin and kaempferol aglycones and glucuronides on peroxisome proliferator-activated receptor-gamma (PPAR-). Food Funct. 2015 Apr;6(4):1098-107. doi: 10.1039/c5fo00076a.
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986 Glucosamine sulfate reduces prostaglandin E(2) production in osteoarthritic chondrocytes through inhibition of microsomal PGE synthase-1. J Rheumatol. 2012 Mar;39(3):635-44. doi: 10.3899/jrheum.110621. Epub 2011 Nov 15.
987 Isoniazid suppresses antioxidant response element activities and impairs adipogenesis in mouse and human preadipocytes. Toxicol Appl Pharmacol. 2013 Dec 15;273(3):435-41. doi: 10.1016/j.taap.2013.10.005. Epub 2013 Oct 12.
988 Aspirin inhibits MMP-9 mRNA expression and release via the PPARalpha/gamma and COX-2/mPGES-1-mediated pathways in macrophages derived from THP-1 cells. Biomed Pharmacother. 2010 Feb;64(2):118-23. doi: 10.1016/j.biopha.2009.04.033. Epub 2009 Oct 17.
989 Mitochondrial proliferation, DNA depletion and adipocyte differentiation in subcutaneous adipose tissue of HIV-positive HAART recipients. Antivir Ther. 2003 Aug;8(4):323-31.
990 BET bromodomain inhibition of MYC-amplified medulloblastoma. Clin Cancer Res. 2014 Feb 15;20(4):912-25.
991 Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
992 Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta. Mol Biol Cell. 2004 Mar;15(3):1262-72. doi: 10.1091/mbc.e03-06-0360. Epub 2003 Dec 29.
993 The impact of luteal phase support on gene expression of extracellular matrix protein and adhesion molecules in the human endometrium during the window of implantation following controlled ovarian stimulation with a GnRH antagonist protocol. Fertil Steril. 2010 Nov;94(6):2264-71. doi: 10.1016/j.fertnstert.2010.01.068. Epub 2010 Mar 12.
994 Microarray-based detection and expression analysis of extracellular matrix proteins in drug?resistant ovarian cancer cell lines. Oncol Rep. 2014 Nov;32(5):1981-90. doi: 10.3892/or.2014.3468. Epub 2014 Sep 9.
995 An autocrine loop involving ret and glial cell-derived neurotrophic factor mediates retinoic acid-induced neuroblastoma cell differentiation. Mol Cancer Res. 2006 Jul;4(7):481-8. doi: 10.1158/1541-7786.MCR-06-0050.
996 Adenosine and Cordycepin Accelerate Tissue Remodeling Process through Adenosine Receptor Mediated Wnt/-Catenin Pathway Stimulation by Regulating GSK3b Activity. Int J Mol Sci. 2021 May 25;22(11):5571. doi: 10.3390/ijms22115571.
997 Systematic transcriptome-based comparison of cellular adaptive stress response activation networks in hepatic stem cell-derived progeny and primary human hepatocytes. Toxicol In Vitro. 2021 Jun;73:105107. doi: 10.1016/j.tiv.2021.105107. Epub 2021 Feb 3.
998 RNA sequence analysis of inducible pluripotent stem cell-derived cardiomyocytes reveals altered expression of DNA damage and cell cycle genes in response to doxorubicin. Toxicol Appl Pharmacol. 2018 Oct 1;356:44-53.
999 Behavioral improvement and dopamine release in a Parkinsonian rat model. Neurosci Lett. 2002 Sep 13;330(1):5-8. doi: 10.1016/s0304-3940(02)00672-9.
1000 Glial cell-line derived neurotrophic factor (GDNF) family of ligands confer chemoresistance in a ligand-specific fashion in malignant gliomas. J Clin Neurosci. 2009 Mar;16(3):427-36. doi: 10.1016/j.jocn.2008.06.002. Epub 2009 Jan 12.
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1002 Induction of intestinalization in human esophageal keratinocytes is a multistep process. Carcinogenesis. 2009 Jan;30(1):122-30. doi: 10.1093/carcin/bgn227. Epub 2008 Oct 8.
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1004 Research resource: STR DNA profile and gene expression comparisons of human BG-1 cells and a BG-1/MCF-7 clonal variant. Mol Endocrinol. 2014 Dec;28(12):2072-81.
1005 Am80-GCSF synergizes myeloid expansion and differentiation to generate functional neutrophils that reduce neutropenia-associated infection and?mortality. EMBO Mol Med. 2016 Nov 2;8(11):1340-1359. doi: 10.15252/emmm.201606434. Print 2016 Nov.
1006 Copper deprivation enhances the chemosensitivity of pancreatic cancer to rapamycin by mTORC1/2 inhibition. Chem Biol Interact. 2023 Sep 1;382:110546. doi: 10.1016/j.cbi.2023.110546. Epub 2023 Jun 7.
1007 Structural determinants of opioid and NOP receptor activity in derivatives of buprenorphine. J Med Chem. 2011 Oct 13;54(19):6531-7. doi: 10.1021/jm2003238. Epub 2011 Sep 7.
1008 Gene expression profile changes in NB4 cells induced by arsenic trioxide. Acta Pharmacol Sin. 2003 Jul;24(7):646-50.
1009 Ouabain impairs cell migration, and invasion and alters gene expression of human osteosarcoma U-2 OS cells. Environ Toxicol. 2017 Nov;32(11):2400-2413. doi: 10.1002/tox.22453. Epub 2017 Aug 10.
1010 Responsiveness of human monocyte-derived dendritic cells to thimerosal and mercury derivatives. Toxicol Appl Pharmacol. 2010 Jul;246(1-2):66-73. doi: 10.1016/j.taap.2010.04.007. Epub 2010 Apr 22.
1011 A plasmacytoid dendritic cell (CD123+/CD11c-) based assay system to predict contact allergenicity of chemicals. Toxicology. 2009 Oct 1;264(1-2):1-9. doi: 10.1016/j.tox.2009.07.021. Epub 2009 Aug 7.
1012 Oxidative stress triggers STAT3 tyrosine phosphorylation and nuclear translocation in human lymphocytes. J Biol Chem. 1999 Jun 18;274(25):17580-6. doi: 10.1074/jbc.274.25.17580.
1013 Molecular mechanisms underlying the inhibition of IFN--induced, STAT1-mediated gene transcription in human macrophages by simvastatin and agonists of PPARs and LXRs. J Cell Biochem. 2011 Feb;112(2):675-83. doi: 10.1002/jcb.22976.
1014 Benzodithiophenes potentiate differentiation of acute promyelocytic leukemia cells by lowering the threshold for ligand-mediated corepressor/coactivator exchange with retinoic acid receptor alpha and enhancing changes in all-trans-retinoic acid-regulated gene expression. Cancer Res. 2005 Sep 1;65(17):7856-65. doi: 10.1158/0008-5472.CAN-05-1056.
1015 eIF4E is a critical regulator of human papillomavirus (HPV)-immortalized cervical epithelial (H8) cell growth induced by nicotine. Toxicology. 2019 May 1;419:1-10. doi: 10.1016/j.tox.2019.02.017. Epub 2019 Mar 2.
1016 Repression of Kisspeptin1 weakens hydrogen peroxide-caused injury in HTR8 cells via adjusting PI3K/AKT/mTOR pathway. J Biochem Mol Toxicol. 2020 May;34(5):e22461. doi: 10.1002/jbt.22461. Epub 2020 Feb 11.
1017 Quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting VEGFR- 2 regulated AKT/mTOR/P70S6K signaling pathways. PLoS One. 2012;7(10):e47516. doi: 10.1371/journal.pone.0047516. Epub 2012 Oct 18.
1018 Carbamylation and oxidation of proteins lead to apoptotic death of lymphocytes. Chem Biol Interact. 2017 May 25;270:24-32. doi: 10.1016/j.cbi.2017.04.007. Epub 2017 Apr 8.
1019 Actinomycin D and staurosporine, potent apoptosis inducers in vitro, are potentially effective chemotherapeutic agents against glioblastoma multiforme. Cancer Chemother Pharmacol. 2000;45(2):149-56. doi: 10.1007/s002800050023.
1020 Quercetin-induced apoptosis of HL-60 cells by reducing PI3K/Akt. Mol Biol Rep. 2012 Jul;39(7):7785-93. doi: 10.1007/s11033-012-1621-0. Epub 2012 May 4.
1021 Clonidine Induces Apoptosis of Human Corneal Epithelial Cells through Death Receptors-Mediated, Mitochondria-Dependent Signaling Pathway. Toxicol Sci. 2017 Mar 1;156(1):252-260. doi: 10.1093/toxsci/kfw249.
1022 Lovastatin induces apoptosis of anaplastic thyroid cancer cells via inhibition of protein geranylgeranylation and de novo protein synthesis. Endocrinology. 2003 Sep;144(9):3852-9. doi: 10.1210/en.2003-0098.
1023 Cisplatin induces autophagy to enhance hepatitis B virus replication via activation of ROS/JNK and inhibition of the Akt/mTOR pathway. Free Radic Biol Med. 2019 Feb 1;131:225-236. doi: 10.1016/j.freeradbiomed.2018.12.008. Epub 2018 Dec 11.
1024 Disease-modifying effects of glucosamine HCl involving regulation of metalloproteinases and chemokines activated by interleukin-1beta in human primary synovial fibroblasts. J Cell Biochem. 2008 May 1;104(1):38-50. doi: 10.1002/jcb.21597.
1025 Characterization of cell death induced by ethacrynic acid in a human colon cancer cell line DLD-1 and suppression by N-acetyl-L-cysteine. Cancer Sci. 2003 Oct;94(10):886-93.
1026 Methotrexate increases expression of cell cycle checkpoint genes via JNK activation. Arthritis Rheum. 2012 Jun;64(6):1780-9. doi: 10.1002/art.34342. Epub 2011 Dec 19.
1027 Synergistic promotion of breast cancer cells death by targeting molecular chaperone GRP78 and heat shock protein 70. J Cell Mol Med. 2009 Nov-Dec;13(11-12):4540-50. doi: 10.1111/j.1582-4934.2008.00575.x.
1028 Arsenic trioxide induces apoptosis in chronic myelogenous leukemia K562 cells: possible involvement of p38 MAP kinase. J Biochem Mol Biol. 2002 Jul 31;35(4):377-83. doi: 10.5483/bmbrep.2002.35.4.377.
1029 Intracellular mobility and nuclear trafficking of the stress-activated kinase JNK1 are impeded by hyperosmotic stress. Biochim Biophys Acta. 2014 Feb;1843(2):253-64. doi: 10.1016/j.bbamcr.2013.10.017. Epub 2013 Nov 1.
1030 Quercetin attenuates cell apoptosis of oxidant-stressed SK-N-MC cells while suppressing up-regulation of the defensive element, HIF-1alpha. Neuroscience. 2014 Sep 26;277:780-93.
1031 Arsenic trioxide inhibits cell growth and induces apoptosis through inactivation of notch signaling pathway in breast cancer. Int J Mol Sci. 2012;13(8):9627-9641. doi: 10.3390/ijms13089627. Epub 2012 Aug 2.
1032 Propranolol inhibits proliferation and invasion of hemangioma-derived endothelial cells by suppressing the DLL4/Notch1/Akt pathway. Chem Biol Interact. 2018 Oct 1;294:28-33. doi: 10.1016/j.cbi.2018.08.018. Epub 2018 Aug 18.
1033 NOTCH signaling is activated in and contributes to resistance in enzalutamide-resistant prostate cancer cells. J Biol Chem. 2019 May 24;294(21):8543-8554. doi: 10.1074/jbc.RA118.006983. Epub 2019 Apr 2.
1034 The autonomous notch signal pathway is activated by baicalin and baicalein but is suppressed by niclosamide in K562 cells. J Cell Biochem. 2009 Mar 1;106(4):682-92. doi: 10.1002/jcb.22065.
1035 Mebendazole is a potent inhibitor to chemoresistant T cell acute lymphoblastic leukemia cells. Toxicol Appl Pharmacol. 2020 Jun 1;396:115001. doi: 10.1016/j.taap.2020.115001. Epub 2020 Apr 8.
1036 NF-B potentiates caspase independent hydrogen peroxide induced cell death. PLoS One. 2011 Feb 15;6(2):e16815. doi: 10.1371/journal.pone.0016815.
1037 Quercetin induces FasL-related apoptosis, in part, through promotion of histone H3 acetylation in human leukemia HL-60 cells. Oncol Rep. 2011 Feb;25(2):583-91. doi: 10.3892/or.2010.1097. Epub 2010 Dec 10.
1038 Influence of antitumor drugs on the expression of Fas system in SW480 colon cancer cells. Eur J Gastroenterol Hepatol. 2006 Oct;18(10):1071-7. doi: 10.1097/01.meg.0000231750.68513.6c.
1039 Acrolein enhances epigenetic modifications, FasL expression and hepatocyte toxicity induced by anti-HIV drug Zidovudine. Toxicol In Vitro. 2016 Sep;35:66-76. doi: 10.1016/j.tiv.2016.05.013. Epub 2016 May 26.
1040 Rifampicin inhibits CD95-mediated apoptosis of Jurkat T cells via glucocorticoid receptors by modifying the expression of molecules regulating apoptosis. J Clin Immunol. 2002 Jan;22(1):37-47. doi: 10.1023/a:1014256603539.
1041 Essential role of Nrf2 in keratinocyte protection from UVA by quercetin. Biochem Biophys Res Commun. 2009 Sep 11;387(1):109-14. doi: 10.1016/j.bbrc.2009.06.136. Epub 2009 Jul 1.
1042 An in vitro skin sensitization assay termed EpiSensA for broad sets of chemicals including lipophilic chemicals and pre/pro-haptens. Toxicol In Vitro. 2017 Apr;40:11-25. doi: 10.1016/j.tiv.2016.12.005. Epub 2016 Dec 10.
1043 Quercetin in elimination of tumor initiating stem-like and mesenchymal transformation property in head and neck cancer. Head Neck. 2013 Mar;35(3):413-9. doi: 10.1002/hed.22982. Epub 2012 Mar 16.
1044 Organochloride pesticides induced hepatic ABCG5/G8 expression and lipogenesis in Chinese patients with gallstone disease. Oncotarget. 2016 Jun 7;7(23):33689-702. doi: 10.18632/oncotarget.9399.
1045 Effect of atorvastatin, simvastatin, and lovastatin on the metabolism of cholesterol and triacylglycerides in HepG2 cells. Biochem Pharmacol. 2001 Dec 1;62(11):1545-55. doi: 10.1016/s0006-2952(01)00790-0.
1046 Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):245-55.
1047 Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21.
1048 Regulation of secretases by all-trans-retinoic acid. FEBS J. 2009 May;276(9):2645-55. doi: 10.1111/j.1742-4658.2009.06992.x. Epub 2009 Mar 25.
1049 Effects of paclitaxel on proliferation and apoptosis in human acute myeloid leukemia HL-60 cells. Acta Pharmacol Sin. 2004 Mar;25(3):378-84.
1050 Epigenetic changes in individuals with arsenicosis. Chem Res Toxicol. 2011 Feb 18;24(2):165-7. doi: 10.1021/tx1004419. Epub 2011 Feb 4.
1051 Impact of quercetin and EGCG on key elements of the Wnt pathway in human colon carcinoma cells. J Agric Food Chem. 2006 Sep 20;54(19):7075-82. doi: 10.1021/jf0612530.
1052 GSK3, snail, and adhesion molecule regulation by cyclosporine A in renal tubular cells. Toxicol Sci. 2012 Jun;127(2):425-37. doi: 10.1093/toxsci/kfs108. Epub 2012 Mar 12.
1053 Methamphetamine exposure upregulates the amyloid precursor protein and hyperphosphorylated tau expression: The roles of insulin signaling in SH-SY5Y cell line. J Toxicol Sci. 2019;44(7):493-503. doi: 10.2131/jts.44.493.
1054 Increased galectin-3 facilitates leukemia cell survival from apoptotic stimuli. Biochem Biophys Res Commun. 2011 Aug 26;412(2):334-40. doi: 10.1016/j.bbrc.2011.07.099. Epub 2011 Jul 29.
1055 Effects and mechanisms of betulinic acid on improving EGFR TKI-resistance of lung cancer cells. Environ Toxicol. 2018 Nov;33(11):1153-1159.
1056 The protective effects of liraglutide on AD-like neurodegeneration induced by oxidative stress in human neuroblastoma SH-SY5Y cells. Chem Biol Interact. 2019 Sep 1;310:108688. doi: 10.1016/j.cbi.2019.06.001. Epub 2019 Jun 4.
1057 Differential effects of simvastatin and pravastatin on expression of Alzheimer's disease-related genes in human astrocytes and neuronal cells. J Lipid Res. 2009 Oct;50(10):2095-102. doi: 10.1194/jlr.M900236-JLR200. Epub 2009 May 21.
1058 Suppression of NF-kappaB and GSK-3beta is involved in colon cancer cell growth inhibition by the PPAR agonist troglitazone. Chem Biol Interact. 2010 Oct 6;188(1):75-85. doi: 10.1016/j.cbi.2010.06.001. Epub 2010 Jun 9.
1059 Copper chelator ATN-224 inhibits endothelial function by multiple mechanisms. Microvasc Res. 2009 May;77(3):314-26.
1060 Differential anti-proliferative actions of peroxisome proliferator-activated receptor-gamma agonists in MCF-7 breast cancer cells. Biochem Pharmacol. 2006 Aug 28;72(5):530-40. doi: 10.1016/j.bcp.2006.05.009. Epub 2006 Jun 27.
1061 Pharmacogenomic identification of novel determinants of response to chemotherapy in colon cancer. Cancer Res. 2006 Mar 1;66(5):2765-77.
1062 Long-term estrogen exposure promotes carcinogen bioactivation, induces persistent changes in gene expression, and enhances the tumorigenicity of MCF-7 human breast cancer cells. Toxicol Appl Pharmacol. 2009 Nov 1;240(3):355-66.
1063 Marked regression of liver metastasis by combined therapy of ultrasound-mediated NF kappaB-decoy transfer and transportal injection of paclitaxel, in mouse. Int J Cancer. 2008 Apr 1;122(7):1645-56. doi: 10.1002/ijc.23280.
1064 Gene alterations of ovarian cancer cells expressing estrogen receptors by estrogen and bisphenol a using microarray analysis. Lab Anim Res. 2011 Jun;27(2):99-107. doi: 10.5625/lar.2011.27.2.99. Epub 2011 Jun 22.
1065 A proteomic analysis of acute leukemia cells treated with 9-hydroxyoctadecadienoic acid. Lipids Health Dis. 2016 Nov 10;15(1):192. doi: 10.1186/s12944-016-0359-4.
1066 Direct transcriptomic comparison of xenobiotic metabolism and toxicity pathway induction of airway epithelium models at an air-liquid interface generated from induced pluripotent stem cells and primary bronchial epithelial cells. Cell Biol Toxicol. 2023 Feb;39(1):1-18. doi: 10.1007/s10565-022-09726-0. Epub 2022 May 31.
1067 PLK1 targets NOTCH1 during DNA damage and mitotic progression. J Biol Chem. 2019 Nov 22;294(47):17941-17950. doi: 10.1074/jbc.RA119.009881. Epub 2019 Oct 9.
1068 Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells. Chem Res Toxicol. 2014 Mar 17;27(3):408-20.
1069 Transcriptional repression of IKK by p53 in arsenite-induced GADD45 accumulation and apoptosis. Oncogene. 2019 Jan;38(5):731-746. doi: 10.1038/s41388-018-0478-7. Epub 2018 Sep 3.
1070 The use of genomics technology to investigate gene expression changes in cultured human liver cells. Toxicol In Vitro. 2001 Aug-Oct;15(4-5):399-405. doi: 10.1016/s0887-2333(01)00043-1.
1071 Bone marrow osteoblast damage by chemotherapeutic agents. PLoS One. 2012;7(2):e30758. doi: 10.1371/journal.pone.0030758. Epub 2012 Feb 17.
1072 A model to identify novel targets involved in oxidative stress-induced apoptosis in human lung epithelial cells by RNA interference. Toxicol In Vitro. 2010 Feb;24(1):310-8. doi: 10.1016/j.tiv.2009.08.008. Epub 2009 Aug 23.
1073 Nitric oxide inhibits execution of apoptosis at two distinct ATP-dependent steps upstream and downstream of mitochondrial cytochrome c release. Biochem Biophys Res Commun. 1999 Apr 29;258(1):215-21. doi: 10.1006/bbrc.1999.0491.
1074 Palmitate increases the susceptibility of cells to drug-induced toxicity: an in vitro method to identify drugs with potential contraindications in patients with metabolic disease. Toxicol Sci. 2012 Oct;129(2):346-62. doi: 10.1093/toxsci/kfs208. Epub 2012 Jun 14.
1075 Simvastatin induces apoptosis and alters cytoskeleton in endometrial stromal cells. J Clin Endocrinol Metab. 2010 Jul;95(7):3453-9. doi: 10.1210/jc.2010-0072. Epub 2010 Apr 28.
1076 The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib. Toxicol Sci. 2023 Dec 21;197(1):69-78. doi: 10.1093/toxsci/kfad099.
1077 Insulin-like growth factor I prevents mannitol-induced degradation of focal adhesion kinase and Akt. J Biol Chem. 2002 Jul 26;277(30):27393-400. doi: 10.1074/jbc.M201963200. Epub 2002 May 14.
1078 Effects of gonadotrophin-releasing hormone agonists on apoptosis of granulosa cells. Ann N Y Acad Sci. 2005 May;1042:531-7. doi: 10.1196/annals.1338.065.
1079 Inhibiting AKT signaling pathway with cilostazol and meloxicam synergism for suppressing K562 cells in vitro. J Biochem Mol Toxicol. 2022 Nov;36(11):e23185. doi: 10.1002/jbt.23185. Epub 2022 Aug 3.
1080 Colchicine-induced apoptosis in human normal liver L-02 cells by mitochondrial mediated pathways. Toxicol In Vitro. 2012 Aug;26(5):649-55. doi: 10.1016/j.tiv.2012.01.024. Epub 2012 Feb 8.
1081 Epigenetic silencing of novel tumor suppressors in malignant melanoma. Cancer Res. 2006 Dec 1;66(23):11187-93. doi: 10.1158/0008-5472.CAN-06-1274.
1082 Combination of Poly I:C and arsenic trioxide triggers apoptosis synergistically via activation of TLR3 and mitochondrial pathways in hepatocellular carcinoma cells. Cell Biol Int. 2011 Aug;35(8):803-10. doi: 10.1042/CBI20100739.
1083 Role of mitochondria in aspirin-induced apoptosis in human gastric epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2005 Oct;289(4):G731-8. doi: 10.1152/ajpgi.00150.2005. Epub 2005 Jun 23.
1084 p38 MAPK/PP2Ac/TTP pathway on the connection of TNF- and caspases activation on hydroquinone-induced apoptosis. Carcinogenesis. 2013 Apr;34(4):818-27. doi: 10.1093/carcin/bgs409. Epub 2013 Jan 3.
1085 Serum interleukin-2 and tumor necrosis factor-alpha in primary biliary cirrhosis: decrease by colchicine and relationship to HLA-DR4. Am J Gastroenterol. 1992 Apr;87(4):465-70.
1086 Involvement of C3435T and G2677T multidrug resistance gene polymorphisms in release of cytokines from peripheral blood mononuclear cells treated with methotrexate and dexamethasone. Eur J Pharmacol. 2005 Dec 28;528(1-3):27-36. doi: 10.1016/j.ejphar.2005.10.068.
1087 Interleukin-2-induced antinociception in morphine-insensitive rats. Acta Pharmacol Sin. 2002 Nov;23(11):981-4.
1088 Delta 9-Tetrahydrocannabinol regulates Th1/Th2 cytokine balance in activated human T cells. J Neuroimmunol. 2002 Dec;133(1-2):124-31. doi: 10.1016/s0165-5728(02)00370-3.
1089 opioid receptor agonist-selective regulation of interleukin-4 in T lymphocytes. J Neuroimmunol. 2013 Oct 15;263(1-2):35-42. doi: 10.1016/j.jneuroim.2013.07.012. Epub 2013 Jul 25.
1090 1,25-Dihydroxyvitamin D3-regulated expression of genes involved in human T-lymphocyte proliferation and differentiation. Cancer Res. 1986 Nov;46(11):5827-31.
1091 Inhibition of fatty acid synthase expression by 1alpha,25-dihydroxyvitamin D3 in prostate cancer cells. J Steroid Biochem Mol Biol. 2003 May;85(1):1-8. doi: 10.1016/s0960-0760(03)00142-0.
1092 Proteomic analysis of anti-cancer effects by paclitaxel treatment in cervical cancer cells. Gynecol Oncol. 2005 Jul;98(1):45-53. doi: 10.1016/j.ygyno.2005.04.010.
1093 Antiepileptic drugs are endocrine disruptors for the human fetal testis ex vivo. Toxicol Sci. 2023 Sep 28;195(2):169-183. doi: 10.1093/toxsci/kfad076.
1094 Cannabinoids synergize with carfilzomib, reducing multiple myeloma cells viability and migration. Oncotarget. 2016 Nov 22;7(47):77543-77557. doi: 10.18632/oncotarget.12721.
1095 Arsenic trioxide inhibits CXCR4-mediated metastasis by interfering miR-520h/PP2A/NF-B signaling in cervical cancer. Ann Surg Oncol. 2014 Dec;21 Suppl 4:S687-95. doi: 10.1245/s10434-014-3812-5. Epub 2014 Jul 22.
1096 Etodolac induces apoptosis and inhibits cell adhesion to bone marrow stromal cells in human myeloma cells. Leuk Res. 2006 Feb;30(2):123-35. doi: 10.1016/j.leukres.2005.06.009. Epub 2005 Jul 25.
1097 TGF-1 signaling protects retinal ganglion cells from oxidative stress via modulation of the HO-1/Nrf2 pathway. Chem Biol Interact. 2020 Nov 1;331:109249. doi: 10.1016/j.cbi.2020.109249. Epub 2020 Sep 24.
1098 Troglitazone suppresses transforming growth factor beta-mediated fibrogenesis in retinal pigment epithelial cells. Mol Vis. 2008 Jan 18;14:95-104.
1099 Towards dissecting the pathogenesis of retinoid-induced hair loss: all-trans retinoic acid induces premature hair follicle regression (catagen) by upregulation of transforming growth factor-beta2 in the dermal papilla. J Invest Dermatol. 2005 Jun;124(6):1119-26. doi: 10.1111/j.0022-202X.2005.23686.x.
1100 Growth inhibition of ovarian tumor-initiating cells by niclosamide. Mol Cancer Ther. 2012 Aug;11(8):1703-12.
1101 Transcriptional profiling in the human prefrontal cortex: evidence for two activational states associated with cocaine abuse. Pharmacogenomics J. 2003;3(1):27-40.
1102 Quercetin suppresses pancreatic ductal adenocarcinoma progression via inhibition of SHH and TGF-/Smad signaling pathways. Cell Biol Toxicol. 2021 Jun;37(3):479-496. doi: 10.1007/s10565-020-09562-0. Epub 2020 Oct 17.
1103 Comparison of the antifibrotic effects of the pan-histone deacetylase-inhibitor panobinostat versus the IPF-drug pirfenidone in fibroblasts from patients with idiopathic pulmonary fibrosis. PLoS One. 2018 Nov 27;13(11):e0207915. doi: 10.1371/journal.pone.0207915. eCollection 2018.
1104 Arsenic trioxide inhibits the differentiation of fibroblasts to myofibroblasts through nuclear factor erythroid 2-like 2 (NFE2L2) protein and the Smad2/3 pathway. J Cell Physiol. 2019 Mar;234(3):2606-2617. doi: 10.1002/jcp.27073. Epub 2018 Oct 14.
1105 Targeting the myofibroblast genetic switch: inhibitors of myocardin-related transcription factor/serum response factor-regulated gene transcription prevent fibrosis in a murine model of skin injury. J Pharmacol Exp Ther. 2014 Jun;349(3):480-6. doi: 10.1124/jpet.114.213520. Epub 2014 Apr 4.
1106 Proteomics analysis of the proliferative effect of low-dose ouabain on human endothelial cells. Biol Pharm Bull. 2007 Feb;30(2):247-53. doi: 10.1248/bpb.30.247.
1107 How benzene and its metabolites affect human marrow derived mesenchymal stem cells. Toxicol Lett. 2012 Oct 17;214(2):145-53. doi: 10.1016/j.toxlet.2012.08.015. Epub 2012 Aug 30.
1108 Hydroquinone-induced miR-122 down-regulation elicits ADAM17 up-regulation, leading to increased soluble TNF- production in human leukemia cells with expressed Bcr/Abl. Biochem Pharmacol. 2013 Sep 1;86(5):620-31. doi: 10.1016/j.bcp.2013.06.009. Epub 2013 Jun 20.
1109 The nitrogen-containing bisphosphonate, zoledronic acid, influences RANKL expression in human osteoblast-like cells by activating TNF-alpha converting enzyme (TACE). J Bone Miner Res. 2004 Jan;19(1):147-54. doi: 10.1359/jbmr.2004.19.1.147.
1110 Extremely low copper concentrations affect gene expression profiles of human prostate epithelial cell lines. Chem Biol Interact. 2010 Oct 6;188(1):214-9.
1111 Application of cDNA microarray to the study of arsenic-induced liver diseases in the population of Guizhou, China. Toxicol Sci. 2001 Jan;59(1):185-92.
1112 Molecular mechanisms of action of angiopreventive anti-oxidants on endothelial cells: microarray gene expression analyses. Mutat Res. 2005 Dec 11;591(1-2):198-211.
1113 Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(a)pyrene. Toxicol Sci. 2010 Apr;114(2):247-59.
1114 Expression of connective tissue growth factor, a biomarker in senescence of human diploid fibroblasts, is up-regulated by a transforming growth factor-beta-mediated signaling pathway. Biochem Biophys Res Commun. 2004 Jun 11;318(4):819-25. doi: 10.1016/j.bbrc.2004.04.108.
1115 Suppression of transforming growth factor beta/smad signaling in keloid-derived fibroblasts by quercetin: implications for the treatment of excessive scars. J Trauma. 2004 Nov;57(5):1032-7. doi: 10.1097/01.ta.0000114087.46566.eb.
1116 Inhibition of TGF-/SMAD3/NF-B signaling by microRNA-491 is involved in arsenic trioxide-induced anti-angiogenesis in hepatocellular carcinoma cells. Toxicol Lett. 2014 Nov 18;231(1):55-61. doi: 10.1016/j.toxlet.2014.08.024. Epub 2014 Sep 6.
1117 Identification and Profiling of Environmental Chemicals That Inhibit the TGF/SMAD Signaling Pathway. Chem Res Toxicol. 2019 Dec 16;32(12):2433-2444. doi: 10.1021/acs.chemrestox.9b00228. Epub 2019 Nov 11.
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1119 Histamine induces MUC5AC expression via a hCLCA1 pathway. Pharmacology. 2007;80(4):219-26. doi: 10.1159/000104419. Epub 2007 Jul 5.
1120 Transient receptor potential vanilloid 1 receptors mediate acid-induced mucin secretion via Ca2+ influx in human airway epithelial cells. J Biochem Mol Toxicol. 2012 May;26(5):179-86. doi: 10.1002/jbt.20413. Epub 2012 May 7.
1121 Assessing the respiratory toxicity of dihydroxyacetone using an in vitro human airway epithelial tissue model. Toxicol In Vitro. 2019 Sep;59:78-86. doi: 10.1016/j.tiv.2019.04.007. Epub 2019 Apr 5.
1122 Agents associated with lung inflammation induce similar responses in NCI-H292 lung epithelial cells. Toxicol In Vitro. 2008 Oct;22(7):1782-8.
1123 Regulation of ERRalpha gene expression by estrogen receptor agonists and antagonists in SKBR3 breast cancer cells: differential molecular mechanisms mediated by g protein-coupled receptor GPR30/GPER-1. Mol Endocrinol. 2010 May;24(5):969-80. doi: 10.1210/me.2009-0148. Epub 2010 Mar 8.
1124 Troglitazone induces cytotoxicity in part by promoting the degradation of peroxisome proliferator-activated receptor co-activator-1 protein. Br J Pharmacol. 2010 Oct;161(4):771-81. doi: 10.1111/j.1476-5381.2010.00900.x.
1125 Under ambient UVA exposure, pefloxacin exhibits both immunomodulatory and genotoxic effects via multiple mechanisms. J Photochem Photobiol B. 2018 Jan;178:593-605. doi: 10.1016/j.jphotobiol.2017.12.014. Epub 2017 Dec 15.
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1127 Differential expression of genes induced by resveratrol in LNCaP cells: P53-mediated molecular targets. Int J Cancer. 2003 Mar 20;104(2):204-12.
1128 Acetylation and phosphorylation of SRSF2 control cell fate decision in response to cisplatin. EMBO J. 2011 Feb 2;30(3):510-23. doi: 10.1038/emboj.2010.333. Epub 2010 Dec 14.
1129 Cannabidiol and Oxygen-Ozone Combination Induce Cytotoxicity in Human Pancreatic Ductal Adenocarcinoma Cell Lines. Cancers (Basel). 2020 Sep 27;12(10):2774. doi: 10.3390/cancers12102774.
1130 Ciprofloxacin mediates cancer stem cell phenotypes in lung cancer cells through caveolin-1-dependent mechanism. Chem Biol Interact. 2016 Apr 25;250:1-11.
1131 Retinoic acid represses a cassette of candidate pluripotency chromosome 12p genes during induced loss of human embryonal carcinoma tumorigenicity. Biochim Biophys Acta. 2005 Oct 15;1731(1):48-56. doi: 10.1016/j.bbaexp.2005.08.006. Epub 2005 Sep 1.
1132 Arsenic trioxide induces differentiation of cancer stem cells in hepatocellular carcinoma through inhibition of LIF/JAK1/STAT3 and NF-kB signaling pathways synergistically. Clin Transl Med. 2021 Feb;11(2):e335. doi: 10.1002/ctm2.335.
1133 Altered expression of genes identified in rats with prostatic chronic inflammation in a prostate spheroid model treated by estradiol/testosterone. J Toxicol Sci. 2021;46(11):515-523. doi: 10.2131/jts.46.515.
1134 Effects of Exposure to Acetaminophen and Ibuprofen on Fetal Germ Cell Development in Both Sexes in Rodent and Human Using Multiple Experimental Systems. Environ Health Perspect. 2018 Apr 16;126(4):047006. doi: 10.1289/EHP2307.
1135 ZD6474 inhibits tumor growth and intraperitoneal dissemination in a highly metastatic orthotopic gastric cancer model. Int J Cancer. 2006 Jan 15;118(2):483-9. doi: 10.1002/ijc.21340.
1136 Pretreatment of 3-MA prevents doxorubicin-induced cardiotoxicity through inhibition of autophagy initiation. Toxicology. 2023 May 15;490:153512. doi: 10.1016/j.tox.2023.153512. Epub 2023 Apr 14.
1137 Differential gene expression of sulindac-treated human breast epithelial cells. Int J Oncol. 2005 Dec;27(6):1727-36.
1138 Peroxisome proliferator-activated receptor-gamma agonists inhibit respiratory syncytial virus-induced expression of intercellular adhesion molecule-1 in human lung epithelial cells. Immunology. 2007 May;121(1):71-81. doi: 10.1111/j.1365-2567.2006.02539.x.
1139 Glucosamine regulation of LPS-mediated inflammation in human bronchial epithelial cells. Eur J Pharmacol. 2010 Jun 10;635(1-3):219-26. doi: 10.1016/j.ejphar.2010.02.044. Epub 2010 Mar 20.
1140 Evaluation of drug transporters' significance for multidrug resistance in head and neck squamous cell carcinoma. Head Neck. 2011 Jul;33(7):959-68. doi: 10.1002/hed.21559. Epub 2010 Aug 24.
1141 Effects of different sources of copper on Ctr1, ATP7A, ATP7B, MT and DMT1 protein and gene expression in Caco-2 cells. J Trace Elem Med Biol. 2014 Jul;28(3):344-50.
1142 Hormonal regulation of the Menkes and Wilson copper-transporting ATPases in human placental Jeg-3 cells. Biochem J. 2007 Mar 1;402(2):241-50. doi: 10.1042/BJ20061099.
1143 Copper-transporting P-type ATPase, ATP7A, confers multidrug resistance and its expression is related to resistance to SN-38 in clinical colon cancer. Cancer Res. 2007 May 15;67(10):4860-8. doi: 10.1158/0008-5472.CAN-06-3096.
1144 The effect of rare human sequence variants on the function of vesicular monoamine transporter 2. Pharmacogenetics. 2004 Sep;14(9):587-94. doi: 10.1097/00008571-200409000-00003.
1145 Assessing Vesicular Monoamine Transport and Toxicity Using Fluorescent False Neurotransmitters. Chem Res Toxicol. 2021 May 17;34(5):1256-1264. doi: 10.1021/acs.chemrestox.0c00380. Epub 2020 Dec 30.
1146 Synaptic vesicular monoamine transporter expression: distribution and pharmacologic profile. Brain Res Mol Brain Res. 1994 Mar;22(1-4):219-26. doi: 10.1016/0169-328x(94)90050-7.
1147 Gene expression profile of human lymphoid CEM cells sensitive and resistant to glucocorticoid-evoked apoptosis. Genomics. 2003 Jun;81(6):543-55.
1148 Loss of striatal vesicular monoamine transporter protein (VMAT2) in human cocaine users. Am J Psychiatry. 2003 Jan;160(1):47-55. doi: 10.1176/appi.ajp.160.1.47.
1149 The neuroprotective effect of ladostigil against hydrogen peroxide-mediated cytotoxicity. Chem Biol Interact. 2008 Sep 25;175(1-3):318-26. doi: 10.1016/j.cbi.2008.05.038. Epub 2008 Jun 12.
1150 Arsenic trioxide mediates intrinsic and extrinsic pathways of apoptosis and cell cycle arrest in acute megakaryocytic leukemia. Int J Oncol. 2005 Aug;27(2):537-45.
1151 Effect of chemical mutagens and carcinogens on gene expression profiles in human TK6 cells. PLoS One. 2012;7(6):e39205. doi: 10.1371/journal.pone.0039205. Epub 2012 Jun 18.
1152 Ethanol impairs intestinal barrier function in humans through mitogen activated protein kinase signaling: a combined in vivo and in vitro approach. PLoS One. 2014 Sep 16;9(9):e107421. doi: 10.1371/journal.pone.0107421. eCollection 2014.
1153 Hydrocortisone enhances the barrier properties of HBMEC/ci, a brain microvascular endothelial cell line, through mesenchymal-to-endothelial transition-like effects. Fluids Barriers CNS. 2015 Mar 5;12:7. doi: 10.1186/s12987-015-0003-0. eCollection 2015.
1154 Combining kallistatin gene therapy and meloxicam to treat hepatocellular carcinoma in mice. Cancer Sci. 2009 Nov;100(11):2226-33. doi: 10.1111/j.1349-7006.2009.01306.x. Epub 2009 Aug 4.
1155 Expression of the retinoic acid-metabolizing enzyme CYP26A1 limits programmed cell death. Mol Pharmacol. 2005 May;67(5):1808-17. doi: 10.1124/mol.104.005769. Epub 2005 Feb 9.
1156 Role of BAX in the apoptotic response to anticancer agents. Science. 2000 Nov 3;290(5493):989-92. doi: 10.1126/science.290.5493.989.
1157 Simvastatin induces apoptosis in human colon cancer cells and in tumor xenografts, and attenuates colitis-associated colon cancer in mice. Int J Cancer. 2008 Aug 15;123(4):951-7. doi: 10.1002/ijc.23593.
1158 Quercetin downregulates Mcl-1 by acting on mRNA stability and protein degradation. Br J Cancer. 2011 Jul 12;105(2):221-30. doi: 10.1038/bjc.2011.229.
1159 Anti-cancer properties of glucosamine-hydrochloride in YD-8 human oral cancer cells: Induction of the caspase-dependent apoptosis and down-regulation of HIF-1. Toxicol In Vitro. 2012 Feb;26(1):42-50. doi: 10.1016/j.tiv.2011.10.005. Epub 2011 Oct 13.
1160 Ethacrynic acid and a derivative enhance apoptosis in arsenic trioxide-treated myeloid leukemia and lymphoma cells: the role of glutathione S-transferase p1-1. Clin Cancer Res. 2012 Dec 15;18(24):6690-701. doi: 10.1158/1078-0432.CCR-12-0770. Epub 2012 Oct 18.
1161 Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies. J Biol Chem. 2019 Oct 18;294(42):15218-15234. doi: 10.1074/jbc.RA119.009147. Epub 2019 Jul 8.
1162 Benzo[a]pyrene increases the Nrf2 content by downregulating the Keap1 message. Toxicol Sci. 2010 Aug;116(2):549-61.
1163 Simvastatin potentiates TNF-alpha-induced apoptosis through the down-regulation of NF-kappaB-dependent antiapoptotic gene products: role of IkappaBalpha kinase and TGF-beta-activated kinase-1. J Immunol. 2007 Feb 15;178(4):2507-16. doi: 10.4049/jimmunol.178.4.2507.
1164 1-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)-3-(2-(dimethylamino)ethyl)imidazolidin-2-one (ZX-42) inhibits cell proliferation and induces apoptosis via inhibiting ALK and its downstream pathways in Karpas299 cells. Toxicol Appl Pharmacol. 2022 Sep 1;450:116156. doi: 10.1016/j.taap.2022.116156. Epub 2022 Jul 6.
1165 Gene expression profiling in Ishikawa cells: a fingerprint for estrogen active compounds. Toxicol Appl Pharmacol. 2009 Apr 1;236(1):85-96.
1166 Impairment of hypoxia-induced HIF-1 signaling in keratinocytes and fibroblasts by sulfur mustard is counteracted by a selective PHD-2 inhibitor. Arch Toxicol. 2016 May;90(5):1141-50. doi: 10.1007/s00204-015-1549-y. Epub 2015 Jun 17.
1167 Bortezomib and Arsenic Trioxide Activity on a Myelodysplastic Cell Line (P39): A Gene Expression Study. Turk J Haematol. 2015 Sep;32(3):206-12. doi: 10.4274/tjh.2014.0058.
1168 Resistance to diverse apoptotic triggers in multidrug resistant HL60 cells and its possible relationship to the expression of P-glycoprotein, Fas and of the novel anti-apoptosis factors IAP (inhibitory of apoptosis proteins). Cancer Lett. 2002 Jun 6;180(1):91-101. doi: 10.1016/s0304-3835(01)00834-5.
1169 5-Fluorouracil up-regulates interferon pathway gene expression in esophageal cancer cells. Anticancer Res. 2005 Sep-Oct;25(5):3271-8.
1170 Rapid induction of IAP family proteins and Smac/DIABLO expression after proapoptotic stimulation with doxorubicin in RPMI 8226 multiple myeloma cells. Exp Mol Pathol. 2007 Dec;83(3):405-12. doi: 10.1016/j.yexmp.2007.04.001. Epub 2007 Apr 18.
1171 Analysis of gene expression induced by diethylstilbestrol (DES) in human primitive Mullerian duct cells using microarray. Cancer Lett. 2005 Apr 8;220(2):197-210.
1172 Hydroxychloroquine-inhibited dengue virus is associated with host defense machinery. J Interferon Cytokine Res. 2015 Mar;35(3):143-56. doi: 10.1089/jir.2014.0038. Epub 2014 Oct 16.
1173 Proteomic analysis to identify the cellular responses induced by hydroquinone in human embryonic lung fibroblasts. Toxicol Mech Methods. 2006;16(1):1-6. doi: 10.1080/15376520500191797.
1174 A high-content screen identifies novel compounds that inhibit stress-induced TDP-43 cellular aggregation and associated cytotoxicity. J Biomol Screen. 2014 Jan;19(1):44-56. doi: 10.1177/1087057113501553. Epub 2013 Sep 9.
1175 Multiple distinct pathways lead to hyperubiquitylated insoluble TDP-43 protein independent of its translocation into stress granules. J Biol Chem. 2020 Jan 17;295(3):673-689. doi: 10.1074/jbc.RA119.010617. Epub 2019 Nov 28.
1176 Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells. Toxicol Sci. 2011 Mar;120(1):109-22.
1177 An optimized InCell Western screening technique identifies hexachlorophene as a novel potent TDP43 targeting drug. J Biotechnol. 2015 Aug 10;207:34-8. doi: 10.1016/j.jbiotec.2015.04.012. Epub 2015 May 16.
1178 Doxorubicin and selenium cooperatively induce fas signaling in the absence of Fas/Fas ligand interaction. Anticancer Res. 2007 Sep-Oct;27(5A):3075-82.
1179 The role of Fas-FasL-FADD signaling pathway in arsenic-mediated neuronal apoptosis in vivo and in vitro. Toxicol Lett. 2022 Mar 1;356:143-150. doi: 10.1016/j.toxlet.2021.11.012. Epub 2021 Dec 22.
1180 Ursodeoxycholic acid but not tauroursodeoxycholic acid inhibits proliferation and differentiation of human subcutaneous adipocytes. PLoS One. 2013 Dec 3;8(12):e82086. doi: 10.1371/journal.pone.0082086. eCollection 2013.
1181 Hydrogen peroxide triggers a novel alternative splicing of arsenic (+3?oxidation state) methyltransferase gene. Biochem Biophys Res Commun. 2016 Nov 4;480(1):18-22. doi: 10.1016/j.bbrc.2016.10.016. Epub 2016 Oct 6.
1182 [Construction of subtracted cDNA library in human Jurkat T cell line induced by arsenic trioxide in vitro]. Zhonghua Yu Fang Yi Xue Za Zhi. 2003 Nov;37(6):403-7.
1183 Mechanisms of indomethacin-induced alterations in the choline phospholipid metabolism of breast cancer cells. Neoplasia. 2006 Sep;8(9):758-71.
1184 Protective effects of hepatocyte growth factor gene overexpression against hydrogen peroxide-induced apoptosis in mesenchymal stem cells. Environ Toxicol. 2019 Nov;34(11):1236-1245. doi: 10.1002/tox.22824. Epub 2019 Jul 16.
1185 Clozapine induces oxidative stress and proapoptotic gene expression in neutrophils of schizophrenic patients. J Clin Psychopharmacol. 2005 Oct;25(5):419-26. doi: 10.1097/01.jcp.0000177668.42640.fe.
1186 Grouping of histone deacetylase inhibitors and other toxicants disturbing neural crest migration by transcriptional profiling. Neurotoxicology. 2015 Sep;50:56-70.
1187 Ouabain-induced apoptosis and Rho kinase: a novel caspase-2 cleavage site and fragment of Rock-2. Apoptosis. 2010 Dec;15(12):1494-506. doi: 10.1007/s10495-010-0529-1.
1188 Pamidronate induced anti-proliferative, apoptotic, and anti-migratory effects in hepatocellular carcinoma. J Hepatol. 2006 Jan;44(1):142-50. doi: 10.1016/j.jhep.2005.09.022. Epub 2005 Nov 9.
1189 Niclosamide acts as a new inhibitor of vasculogenic mimicry in oral cancer through upregulation of miR-124 and downregulation of STAT3. Oncol Rep. 2018 Feb;39(2):827-833. doi: 10.3892/or.2017.6146. Epub 2017 Dec 11.
1190 Resveratrol modifies the expression of apoptotic regulatory proteins and sensitizes non-Hodgkin's lymphoma and multiple myeloma cell lines to paclitaxel-induced apoptosis. Mol Cancer Ther. 2004 Jan;3(1):71-84.
1191 The hepatotoxic fluoroquinolone trovafloxacin disturbs TNF- and LPS-induced p65 nuclear translocation in vivo and in vitro. Toxicol Appl Pharmacol. 2020 Mar 15;391:114915. doi: 10.1016/j.taap.2020.114915. Epub 2020 Feb 6.
1192 Inhibition of PI3K pathway using BKM120 intensified the chemo-sensitivity of breast cancer cells to arsenic trioxide (ATO). Int J Biochem Cell Biol. 2019 Nov;116:105615. doi: 10.1016/j.biocel.2019.105615. Epub 2019 Sep 17.
1193 Etodolac inhibits EBER expression and induces Bcl-2-regulated apoptosis in Burkitt's lymphoma cells. Eur J Haematol. 2005 Sep;75(3):212-20. doi: 10.1111/j.1600-0609.2005.00498.x.
1194 Apoptosis induction by 1alpha,25-dihydroxyvitamin D3 in prostate cancer. Mol Cancer Ther. 2002 Jul;1(9):667-77.
1195 Autophagy Inhibition Overcomes the Antagonistic Effect Between Gefitinib and Cisplatin in Epidermal Growth Factor Receptor Mutant Non--Small-Cell Lung Cancer Cells. Clin Lung Cancer. 2015 Sep;16(5):e55-66. doi: 10.1016/j.cllc.2015.03.006. Epub 2015 Apr 2.
1196 Harnessing autophagy to overcome mitogen-activated protein kinase kinase inhibitor-induced resistance in metastatic melanoma. Br J Dermatol. 2019 Feb;180(2):346-356. doi: 10.1111/bjd.17333. Epub 2018 Nov 25.
1197 Proteomic analysis of the cellular response to a potent sensitiser unveils the dynamics of haptenation in living cells. Toxicology. 2020 Dec 1;445:152603. doi: 10.1016/j.tox.2020.152603. Epub 2020 Sep 28.
1198 Molecular mechanisms of resveratrol action in lung cancer cells using dual protein and microarray analyses. Cancer Res. 2007 Dec 15;67(24):12007-17. doi: 10.1158/0008-5472.CAN-07-2464.
1199 New insights into BaP-induced toxicity: role of major metabolites in transcriptomics and contribution to hepatocarcinogenesis. Arch Toxicol. 2016 Jun;90(6):1449-58.
1200 Methotrexate induces apoptosis through p53/p21-dependent pathway and increases E-cadherin expression through downregulation of HDAC/EZH2. Biochem Pharmacol. 2011 Feb 15;81(4):510-7. doi: 10.1016/j.bcp.2010.11.014. Epub 2010 Nov 27.
1201 Nrf2 but not autophagy inhibition is associated with the survival of wild-type epidermal growth factor receptor non-small cell lung cancer cells. Toxicol Appl Pharmacol. 2016 Nov 1;310:140-149. doi: 10.1016/j.taap.2016.09.010. Epub 2016 Sep 14.
1202 Calcipotriol induces autophagy in HeLa cells and keratinocytes. J Invest Dermatol. 2011 Apr;131(4):990-3. doi: 10.1038/jid.2010.423. Epub 2011 Jan 13.
1203 The antidepressants maprotiline and fluoxetine induce Type II autophagic cell death in drug-resistant Burkitt's lymphoma. Int J Cancer. 2011 Apr 1;128(7):1712-23. doi: 10.1002/ijc.25477. Epub 2010 May 25.
1204 Autophagy contributes to 4-Amino-2-Trifluoromethyl-Phenyl Retinate-induced differentiation in human acute promyelocytic leukemia NB4 cells. Toxicol Appl Pharmacol. 2017 Mar 15;319:1-11. doi: 10.1016/j.taap.2017.01.016. Epub 2017 Jan 25.
1205 Antitumor effect of arsenic trioxide in human K562 and K562/ADM cells by autophagy. Toxicol Mech Methods. 2012 Sep;22(7):512-9. doi: 10.3109/15376516.2012.686534. Epub 2012 May 22.
1206 Inhibition of autophagy enhances Hydroquinone-induced TK6 cell death. Toxicol In Vitro. 2017 Jun;41:123-132. doi: 10.1016/j.tiv.2017.02.024. Epub 2017 Mar 2.
1207 Functional Profiling Identifies Determinants of Arsenic Trioxide Cellular Toxicity. Toxicol Sci. 2019 May 1;169(1):108-121. doi: 10.1093/toxsci/kfz024.
1208 Interactive gene expression pattern in prostate cancer cells exposed to phenolic antioxidants. Life Sci. 2002 Mar 1;70(15):1821-39.
1209 Proteomic analysis of antiproliferative effects by treatment of 5-fluorouracil in cervical cancer cells. DNA Cell Biol. 2004 Nov;23(11):769-76.
1210 Cytosine arabinoside induces ectoderm and inhibits mesoderm expression in human embryonic stem cells during multilineage differentiation. Br J Pharmacol. 2011 Apr;162(8):1743-56.
1211 Transcriptomic analysis of human primary bronchial epithelial cells after chloropicrin treatment. Chem Res Toxicol. 2015 Oct 19;28(10):1926-35.
1212 Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018 Nov;121:214-223. doi: 10.1016/j.fct.2018.08.034. Epub 2018 Aug 26.
1213 Expression and DNA methylation changes in human breast epithelial cells after bisphenol A exposure. Int J Oncol. 2012 Jul;41(1):369-77.
1214 Mangiferin has an additive effect on the apoptotic properties of hesperidin in Cyclopia sp. tea extracts. PLoS One. 2014 Mar 14;9(3):e92128. doi: 10.1371/journal.pone.0092128. eCollection 2014.
1215 The p38 MAPK pathway mediates aryl propionic acid induced messenger rna stability of p75 NTR in prostate cancer cells. Cancer Res. 2007 Dec 1;67(23):11402-10. doi: 10.1158/0008-5472.CAN-07-1792.
1216 Tyrosine phosphorylation of HuR by JAK3 triggers dissociation and degradation of HuR target mRNAs. Nucleic Acids Res. 2014 Jan;42(2):1196-208. doi: 10.1093/nar/gkt903. Epub 2013 Oct 7.
1217 Amsacrine downregulates BCL2L1 expression and triggers apoptosis in human chronic myeloid leukemia cells through the SIDT2/NOX4/ERK/HuR pathway. Toxicol Appl Pharmacol. 2023 Sep 1;474:116625. doi: 10.1016/j.taap.2023.116625. Epub 2023 Jul 13.
1218 Glucosamine promotes osteogenic differentiation of dental pulp stem cells through modulating the level of the transforming growth factor-beta type I receptor. J Cell Physiol. 2010 Oct;225(1):140-51.
1219 Arsenic trioxide-induced apoptosis and differentiation are associated respectively with mitochondrial transmembrane potential collapse and retinoic acid signaling pathways in acute promyelocytic leukemia. Leukemia. 2000 Feb;14(2):262-70. doi: 10.1038/sj.leu.2401650.
1220 Paroxetine modulates immune responses by activating a JAK2/STAT3 signaling pathway. J Biochem Mol Toxicol. 2020 May;34(5):e22464. doi: 10.1002/jbt.22464. Epub 2020 Feb 5.
1221 [As(2)O(3) Up-Regulates the Proportion of CD4(+)CD25(+)CD127(low) Tregs in Peripheral Blood of Patients with Severe Aplastic Anemia]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2018 Jun;26(3):854-858. doi: 10.7534/j.issn.1009-2137.2018.03.037.
1222 Regulatory T cell function correlates with serum 25-hydroxyvitamin D, but not with 1,25-dihydroxyvitamin D, parathyroid hormone and calcium levels in patients with relapsing remitting multiple sclerosis. J Steroid Biochem Mol Biol. 2010 Jul;121(1-2):243-6. doi: 10.1016/j.jsbmb.2010.03.001. Epub 2010 Mar 6.
1223 Role of N6-methyladenosine RNA modification in the imbalanced inflammatory homeostasis of arsenic-induced skin lesions. Environ Toxicol. 2022 Aug;37(8):1831-1839. doi: 10.1002/tox.23530. Epub 2022 Apr 1.
1224 IL-13 and IL-17A gene polymorphisms in Japanese patients with aspirin-exacerbated respiratory disease. Ann Allergy Asthma Immunol. 2011 Dec;107(6):510-6. doi: 10.1016/j.anai.2011.09.003. Epub 2011 Sep 22.
1225 Grape resveratrol increases serum adiponectin and downregulates inflammatory genes in peripheral blood mononuclear cells: a triple-blind, placebo-controlled, one-year clinical trial in patients with stable coronary artery disease. Cardiovasc Drugs Ther. 2013 Feb;27(1):37-48. doi: 10.1007/s10557-012-6427-8.
1226 Increased expression of VDAC1 sensitizes carcinoma cells to apoptosis induced by DNA cross-linking agents. Biochem Pharmacol. 2012 May 1;83(9):1172-82. doi: 10.1016/j.bcp.2012.01.017. Epub 2012 Jan 21.
1227 Sulindac-derived reactive oxygen species induce apoptosis of human multiple myeloma cells via p38 mitogen activated protein kinase-induced mitochondrial dysfunction. Apoptosis. 2007 Jan;12(1):195-209. doi: 10.1007/s10495-006-0527-5.
1228 Inhibition of lung cancer cell growth by quercetin glucuronides via G2/M arrest and induction of apoptosis. Drug Metab Dispos. 2006 Feb;34(2):296-304. doi: 10.1124/dmd.105.005280. Epub 2005 Nov 9.
1229 Levamisole induced apoptosis in cultured vascular endothelial cells. Br J Pharmacol. 2000 Dec;131(8):1577-83.
1230 Arsenic trioxide (As(2)O(3)) induced apoptosis and its mechanisms in a human esophageal squamous carcinoma cell line. Chin Med J (Engl). 2002 Feb;115(2):280-5.
1231 Non-steroidal anti-inflammatory drugs induce apoptosis in gastric cancer cells through up-regulation of bax and bak. Carcinogenesis. 2001 Sep;22(9):1393-7. doi: 10.1093/carcin/22.9.1393.
1232 Protective effect of quercetin on hydrogen peroxide-induced tight junction disruption. Int J Toxicol. 2010 Jul;29(4):418-24. doi: 10.1177/1091581810366487. Epub 2010 May 5.
1233 Quercetin enhances intestinal barrier function through the assembly of zonula [corrected] occludens-2, occludin, and claudin-1 and the expression of claudin-4 in Caco-2 cells. J Nutr. 2009 May;139(5):965-74. doi: 10.3945/jn.108.100867. Epub 2009 Mar 18.
1234 Arsenite-induced downregulation of occludin in mouse lungs and BEAS-2B cells via the ROS/ERK/ELK1/MLCK and ROS/p38 MAPK signaling pathways. Toxicol Lett. 2020 Oct 10;332:146-154. doi: 10.1016/j.toxlet.2020.07.010. Epub 2020 Jul 16.
1235 The thiopurine methyltransferase genetic polymorphism is associated with thioguanine-related veno-occlusive disease of the liver in children with acute lymphoblastic leukemia. Clin Pharmacol Ther. 2006 Oct;80(4):375-83. doi: 10.1016/j.clpt.2006.07.002.
1236 Translational readthrough by the aminoglycoside geneticin (G418) modulates SMN stability in vitro and improves motor function in SMA mice in vivo. Hum Mol Genet. 2009 Apr 1;18(7):1310-22. doi: 10.1093/hmg/ddp030. Epub 2009 Jan 15.
1237 The PPAR gamma agonist troglitazone induces musclin mRNA expression in human myotubes. Horm Metab Res. 2006 Sep;38(9):614-6. doi: 10.1055/s-2006-951310.
1238 Retinoic acids and trichostatin A (TSA), a histone deacetylase inhibitor, induce human pyruvate dehydrogenase kinase 4 (PDK4) gene expression. Biochim Biophys Acta. 2006 Mar-Apr;1759(3-4):141-51. doi: 10.1016/j.bbaexp.2006.04.005. Epub 2006 Apr 27.
1239 Role of sirtuin 1 in the regulation of hepatic gene expression by thyroid hormone. J Biol Chem. 2013 Jan 11;288(2):807-18. doi: 10.1074/jbc.M112.437970. Epub 2012 Dec 3.
1240 Cannabidiol disrupts apoptosis, autophagy and invasion processes of placental trophoblasts. Arch Toxicol. 2021 Oct;95(10):3393-3406. doi: 10.1007/s00204-021-03122-z. Epub 2021 Jul 24.
1241 AMP-activated protein kinase activity is required for vanadate-induced hypoxia-inducible factor 1alpha expression in DU145 cells. Carcinogenesis. 2004 Dec;25(12):2497-507. doi: 10.1093/carcin/bgh253. Epub 2004 Aug 5.
1242 Identification of chemical compounds that induce HIF-1alpha activity. Toxicol Sci. 2009 Nov;112(1):153-63.
1243 NO-sulindac inhibits the hypoxia response of PC-3 prostate cancer cells via the Akt signalling pathway. Int J Cancer. 2009 Jan 1;124(1):223-32. doi: 10.1002/ijc.23934.
1244 Simvastatin stimulates vascular endothelial growth factor production by hypoxia-inducible factor-1alpha upregulation in endothelial cells. J Cardiovasc Pharmacol. 2008 Mar;51(3):267-73. doi: 10.1097/FJC.0b013e3181624b44.
1245 Epinephrine facilitates the growth of T cell lymphoma by altering cell proliferation, apoptosis, and glucose metabolism. Chem Biol Interact. 2023 Jan 5;369:110278. doi: 10.1016/j.cbi.2022.110278. Epub 2022 Nov 22.
1246 Dose- and time-dependent effects of phenobarbital on gene expression profiling in human hepatoma HepaRG cells. Toxicol Appl Pharmacol. 2009 Feb 1;234(3):345-60.
1247 The effect of folic acid deficiency on Mest/Peg1 in neural tube defects. Int J Neurosci. 2021 May;131(5):468-477. doi: 10.1080/00207454.2020.1750386. Epub 2020 Apr 16.
1248 The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells. Leukemia. 2009 Jun;23(6):1019-28.
1249 Cdk4/6 inhibition induces epithelial-mesenchymal transition and enhances invasiveness in pancreatic cancer cells. Mol Cancer Ther. 2012 Oct;11(10):2138-48. doi: 10.1158/1535-7163.MCT-12-0562. Epub 2012 Aug 6.
1250 Regulation of adiponectin receptors in hepatocytes by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone. Diabetologia. 2006 Jun;49(6):1303-10. doi: 10.1007/s00125-006-0228-1. Epub 2006 Apr 12.
1251 Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions. Pharmacogenomics. 2012 Mar;13(4):399-405. doi: 10.2217/pgs.11.165.
1252 Gene expression in endometrial cancer cells (Ishikawa) after short time high dose exposure to progesterone. Steroids. 2008 Jan;73(1):116-28.
1253 Differential responses to retinoic acid and endocrine disruptor compounds of subpopulations within human embryonic stem cell lines. Differentiation. 2012 Nov;84(4):330-43. doi: 10.1016/j.diff.2012.07.006. Epub 2012 Aug 18.
1254 Transcriptome profile analysis of saturated aliphatic aldehydes reveals carbon number-specific molecules involved in pulmonary toxicity. Chem Res Toxicol. 2014 Aug 18;27(8):1362-70.
1255 Exome-wide mutation profile in benzo[a]pyrene-derived post-stasis and immortal human mammary epithelial cells. Mutat Res Genet Toxicol Environ Mutagen. 2014 Dec;775-776:48-54. doi: 10.1016/j.mrgentox.2014.10.011. Epub 2014 Nov 4.
1256 Multi-level gene expression profiles affected by thymidylate synthase and 5-fluorouracil in colon cancer. BMC Genomics. 2006 Apr 3;7:68. doi: 10.1186/1471-2164-7-68.
1257 Quantitative proteomics and transcriptomics addressing the estrogen receptor subtype-mediated effects in T47D breast cancer cells exposed to the phytoestrogen genistein. Mol Cell Proteomics. 2011 Jan;10(1):M110.002170.
1258 Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma. Oncotarget. 2014 May 15;5(9):2355-71.
1259 Arsenic trioxide promotes ERK1/2-mediated phosphorylation and degradation of BIM(EL) to attenuate apoptosis in BEAS-2B cells. Chem Biol Interact. 2023 Jan 5;369:110304. doi: 10.1016/j.cbi.2022.110304. Epub 2022 Dec 10.
1260 Pterostilbene attenuates RIPK3-dependent hepatocyte necroptosis in alcoholic liver disease via SIRT2-mediated NFATc4 deacetylation. Toxicology. 2021 Sep;461:152923. doi: 10.1016/j.tox.2021.152923. Epub 2021 Aug 30.
1261 Arsenic trioxide reduces the expression of E2F1, cyclin E, and phosphorylation of PI3K signaling molecules in acute leukemia cells. Environ Toxicol. 2021 Sep;36(9):1785-1792. doi: 10.1002/tox.23299. Epub 2021 May 27.
1262 Vitamin D3 induces autophagy of human myeloid leukemia cells. J Biol Chem. 2008 Sep 12;283(37):25596-25605. doi: 10.1074/jbc.M801716200. Epub 2008 Jul 15.
1263 Tumor necrosis factor-alpha-induced protein 3 as a putative regulator of nuclear factor-kappaB-mediated resistance to O6-alkylating agents in human glioblastomas. J Clin Oncol. 2006 Jan 10;24(2):274-87. doi: 10.1200/JCO.2005.02.9405. Epub 2005 Dec 19.
1264 Differently expressed long noncoding RNAs and mRNAs in TK6 cells exposed to low dose hydroquinone. Oncotarget. 2017 Oct 4;8(56):95554-95567. doi: 10.18632/oncotarget.21481. eCollection 2017 Nov 10.
1265 Effects of lithium and valproic acid on gene expression and phenotypic markers in an NT2 neurosphere model of neural development. PLoS One. 2013;8(3):e58822.
1266 Sulforaphane-induced apoptosis in human leukemia HL-60 cells through extrinsic and intrinsic signal pathways and altering associated genes expression assayed by cDNA microarray. Environ Toxicol. 2017 Jan;32(1):311-328.
1267 PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells. J Exp Med. 2006 Oct 2;203(10):2351-62.
1268 Evaluation of gene expression changes in human primary lung epithelial cells following 24-hr exposures to inorganic arsenic and its methylated metabolites and to arsenic trioxide. Environ Mol Mutagen. 2015 Jun;56(5):477-90. doi: 10.1002/em.21937. Epub 2015 Apr 14.
1269 Antihypertrophic Effects of Small Molecules that Maintain Mitochondrial ATP Levels Under Hypoxia. EBioMedicine. 2017 Oct;24:147-158. doi: 10.1016/j.ebiom.2017.09.022. Epub 2017 Sep 19.
1270 LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
1271 Histone Acetyltransferase p300/CREB-binding Protein-associated Factor (PCAF) Is Required for All-trans-retinoic Acid-induced Granulocytic Differentiation in Leukemia Cells. J Biol Chem. 2017 Feb 17;292(7):2815-2829. doi: 10.1074/jbc.M116.745398. Epub 2017 Jan 4.
1272 A pilot study on the transcriptional response of androgen- and insulin-related genes in peripheral blood mononuclear cells induced by testosterone administration in hypogonadal men. J Biol Regul Homeost Agents. 2011 Apr-Jun;25(2):291-4.
1273 Quercetin-mediated Mcl-1 and survivin downregulation restores TRAIL-induced apoptosis in non-Hodgkin's lymphoma B cells. Haematologica. 2012 Jan;97(1):38-46. doi: 10.3324/haematol.2011.046466. Epub 2011 Sep 20.
1274 Arsenic trioxide promotes histone H3 phosphoacetylation at the chromatin of CASPASE-10 in acute promyelocytic leukemia cells. J Biol Chem. 2002 Dec 20;277(51):49504-10. doi: 10.1074/jbc.M207836200. Epub 2002 Oct 17.
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1276 Distinct gene expression responses of two anticonvulsant drugs in a novel human embryonic stem cell based neural differentiation assay protocol. Toxicol In Vitro. 2015 Apr;29(3):449-57. doi: 10.1016/j.tiv.2014.12.001. Epub 2014 Dec 15.
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1278 Sulindac sulfide inhibits epidermal growth factor-induced phosphorylation of extracellular-regulated kinase 1/2 and Bad in human colon cancer cells. Cancer Res. 2003 Feb 1;63(3):616-20.
1279 Simvastatin induces activation of the serine-threonine protein kinase AKT and increases survival of isolated human pancreatic islets. Transplantation. 2002 Oct 27;74(8):1063-9. doi: 10.1097/00007890-200210270-00001.
1280 Quercetin regulates insulin like growth factor signaling and induces intrinsic and extrinsic pathway mediated apoptosis in androgen independent prostate cancer cells (PC-3). Mol Cell Biochem. 2010 Nov;344(1-2):173-84. doi: 10.1007/s11010-010-0540-4. Epub 2010 Jul 25.
1281 Down regulation of N-acetylglucosaminyltransferase V facilitates all-transretinoic acid to induce apoptosis of human hepatocarcinoma cells. Mol Cell Biochem. 2006 Mar;284(1-2):103-10. doi: 10.1007/s11010-005-9022-5. Epub 2006 Jan 13.
1282 Regulation of adiponectin receptor 1 in human hepatocytes by agonists of nuclear receptors. Biochem Biophys Res Commun. 2005 Sep 2;334(3):924-9. doi: 10.1016/j.bbrc.2005.06.187.
1283 Changes in adiponectin receptor expression in muscle and adipose tissue of type 2 diabetic patients during rosiglitazone therapy. Diabetologia. 2005 Aug;48(8):1585-9. doi: 10.1007/s00125-005-1835-y. Epub 2005 Jul 1.
1284 Transcriptome responses in blood reveal distinct biological pathways associated with arsenic exposure through drinking water in rural settings of Punjab, Pakistan. Environ Int. 2020 Feb;135:105403. doi: 10.1016/j.envint.2019.105403. Epub 2019 Dec 18.
1285 Adiponectin Reverses the Proliferative Effects of Estradiol and IGF-1 in Human Epithelial Ovarian Cancer Cells by Downregulating the Expression of Their Receptors. Horm Cancer. 2018 Jun;9(3):166-174. doi: 10.1007/s12672-018-0331-z. Epub 2018 Mar 30.
1286 Interindividual variation in gene expression responses and metabolite formation in acetaminophen-exposed primary human hepatocytes. Arch Toxicol. 2016 May;90(5):1103-15. doi: 10.1007/s00204-015-1545-2. Epub 2015 Jun 24.
1287 Vanin-1: a potential biomarker for nephrotoxicant-induced renal injury. Toxicology. 2011 Nov 28;290(1):82-8. doi: 10.1016/j.tox.2011.08.019. Epub 2011 Sep 3.
1288 Transporter-dependent cytotoxicity of antiviral drugs in primary cultures of human proximal tubular cells. Toxicology. 2018 Jul 1;404-405:10-24. doi: 10.1016/j.tox.2018.05.002. Epub 2018 May 5.
1289 In vitro evaluation of biomarkers of nephrotoxicity through gene expression using gentamicin. J Biochem Mol Toxicol. 2018 Sep;32(9):e22189. doi: 10.1002/jbt.22189. Epub 2018 Jul 10.
1290 Urinary proteomic profiling reveals diclofenac-induced renal injury and hepatic regeneration in mice. Toxicol Appl Pharmacol. 2013 Jun 1;269(2):141-9. doi: 10.1016/j.taap.2013.03.005. Epub 2013 Mar 16.
1291 In vitro evaluation of biomarkers for cisplatin-induced nephrotoxicity using HK-2 human kidney epithelial cells. Toxicol Lett. 2013 Mar 13;217(3):235-42. doi: 10.1016/j.toxlet.2012.12.015. Epub 2012 Dec 31.
1292 Ribavirin inhibits the growth and ascites formation of hepatocellular carcinoma through downregulation of type I CARM1 and type II PRMT5. Toxicol Appl Pharmacol. 2022 Jan 15;435:115829. doi: 10.1016/j.taap.2021.115829. Epub 2021 Dec 14.
1293 Histone arginine methylation in cocaine action in the nucleus accumbens. Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):9623-8. doi: 10.1073/pnas.1605045113. Epub 2016 Aug 9.
1294 Berberine acts as a putative epigenetic modulator by affecting the histone code. Toxicol In Vitro. 2016 Oct;36:10-17. doi: 10.1016/j.tiv.2016.06.004. Epub 2016 Jun 13.
1295 Actinomycin D upregulates proapoptotic protein Puma and downregulates Bcl-2 mRNA in normal peripheral blood lymphocytes. Anticancer Drugs. 2007 Aug;18(7):763-72. doi: 10.1097/CAD.0b013e3280adc905.
1296 Involvement of mitochondrial dysfunction in nefazodone-induced hepatotoxicity. Food Chem Toxicol. 2016 Aug;94:148-58. doi: 10.1016/j.fct.2016.06.001. Epub 2016 Jun 8.
1297 Phenethyl isothiocyanate alters the gene expression and the levels of protein associated with cell cycle regulation in human glioblastoma GBM 8401 cells. Environ Toxicol. 2017 Jan;32(1):176-187.
1298 Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor. Sci Rep. 2014 Sep 26;4:6437. doi: 10.1038/srep06437.
1299 Potency of individual bile acids to regulate bile acid synthesis and transport genes in primary human hepatocyte cultures. Toxicol Sci. 2014 Oct;141(2):538-46. doi: 10.1093/toxsci/kfu151. Epub 2014 Jul 23.
1300 The farnesoid X receptor FXRalpha/NR1H4 acquired ligand specificity for bile salts late in vertebrate evolution. Am J Physiol Regul Integr Comp Physiol. 2007 Sep;293(3):R1400-9. doi: 10.1152/ajpregu.00781.2006. Epub 2007 Jun 13.
1301 Investigation of imatinib and other approved drugs as starting points for antidiabetic drug discovery with FXR modulating activity. Biochem Pharmacol. 2012 Jun 15;83(12):1674-81. doi: 10.1016/j.bcp.2012.02.027. Epub 2012 Mar 7.
1302 DJ-1 is an indicator for endogenous reactive oxygen species elicited by endotoxin. Free Radic Res. 2001 Dec;35(6):885-93. doi: 10.1080/10715760100301381.
1303 Inhibition by pesticides of the DJ-1/Park7 protein related to Parkinson disease. Toxicology. 2023 Mar 15;487:153467. doi: 10.1016/j.tox.2023.153467. Epub 2023 Feb 24.
1304 Phenylbutyrate up-regulates the DJ-1 protein and protects neurons in cell culture and in animal models of Parkinson disease. J Biol Chem. 2011 Apr 29;286(17):14941-51. doi: 10.1074/jbc.M110.211029. Epub 2011 Mar 3.
1305 Mechanisms of DJ-1 neuroprotection in a cellular model of Parkinson's disease. J Neurochem. 2008 Jun 1;105(6):2435-53. doi: 10.1111/j.1471-4159.2008.05333.x.
1306 Identification of novel gene targets and putative regulators of arsenic-associated DNA methylation in human urothelial cells and bladder cancer. Chem Res Toxicol. 2015 Jun 15;28(6):1144-55. doi: 10.1021/tx500393y. Epub 2015 Jun 3.
1307 Cell-type-specific responses to chemotherapeutics in breast cancer. Cancer Res. 2004 Jun 15;64(12):4218-26.
1308 Linalool is a PPARalpha ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome. J Lipid Res. 2014 Jun;55(6):1098-110.
1309 Mitochondrial effects of estrogen are mediated by estrogen receptor alpha in brain endothelial cells. J Pharmacol Exp Ther. 2008 Jun;325(3):782-90. doi: 10.1124/jpet.107.134072. Epub 2008 Mar 19.
1310 Exploring pradimicin-IRD antineoplastic mechanisms and related DNA repair pathways. Chem Biol Interact. 2023 Feb 1;371:110342. doi: 10.1016/j.cbi.2023.110342. Epub 2023 Jan 10.
1311 Gene expression analysis using human cancer xenografts to identify novel predictive marker genes for the efficacy of 5-fluorouracil-based drugs. Cancer Sci. 2006 Jun;97(6):510-22. doi: 10.1111/j.1349-7006.2006.00204.x.
1312 The thioxotriazole copper(II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cells. J Biol Chem. 2009 Sep 4;284(36):24306-19.
1313 Evidence for a role of claudin 2 as a proximal tubular stress responsive paracellular water channel. Toxicol Appl Pharmacol. 2014 Sep 1;279(2):163-72.
1314 The MT1G Gene in LUHMES Neurons Is a Sensitive Biomarker of Neurotoxicity. Neurotox Res. 2020 Dec;38(4):967-978. doi: 10.1007/s12640-020-00272-3. Epub 2020 Sep 1.
1315 Induction of zinc transporters by forskolin in human trophoblast BeWo cells. Reprod Toxicol. 2006 Apr;21(3):285-91. doi: 10.1016/j.reprotox.2005.02.006. Epub 2005 Apr 18.
1316 Toxicogenomics-based identification of mechanisms for direct immunotoxicity. Toxicol Sci. 2013 Oct;135(2):328-46.
1317 Successful validation of genomic biomarkers for human immunotoxicity in Jurkat T cells in vitro. J Appl Toxicol. 2015 Jul;35(7):831-41.
1318 Mitophagy inhibits proliferation by decreasing cyclooxygenase-2 (COX-2) in arsenic trioxide-treated HepG2 cells. Environ Toxicol Pharmacol. 2016 Jul;45:212-21.
1319 Capsaicin inhibits the migration, invasion and EMT of renal cancer cells by inducing AMPK/mTOR-mediated autophagy. Chem Biol Interact. 2022 Oct 1;366:110043. doi: 10.1016/j.cbi.2022.110043. Epub 2022 Aug 28.
1320 PPAR- activation attenuates deltamethrin-induced apoptosis by regulating cytosolic PINK1 and inhibiting mitochondrial dysfunction. Toxicol Lett. 2016 Oct 17;260:8-17. doi: 10.1016/j.toxlet.2016.08.016. Epub 2016 Aug 21.
1321 Melatonin ameliorates acute lung injury caused by paraquat poisoning by promoting PINK1 and BNIP3 expression. Toxicology. 2023 May 15;490:153506. doi: 10.1016/j.tox.2023.153506. Epub 2023 Apr 5.
1322 Fungal cell wall agents suppress the innate inflammatory cytokine responses of human peripheral blood mononuclear cells challenged with lipopolysaccharide in vitro. Int Immunopharmacol. 2011 Aug;11(8):939-47. doi: 10.1016/j.intimp.2011.02.006. Epub 2011 Feb 15.
1323 Cellular reactions to long-term volatile organic compound (VOC) exposures. Sci Rep. 2016 Dec 1;6:37842. doi: 10.1038/srep37842.
1324 Candida albicans and Saccharomyces cerevisiae induce interleukin-8 production from intestinal epithelial-like Caco-2 cells in the presence of butyric acid. FEMS Immunol Med Microbiol. 2004 Jul 1;41(3):227-35. doi: 10.1016/j.femsim.2004.03.006.
1325 Endoplasmic Reticulum Stress Induction and ERK1/2 Activation Contribute to Nefazodone-Induced Toxicity in Hepatic Cells. Toxicol Sci. 2016 Dec;154(2):368-380. doi: 10.1093/toxsci/kfw173. Epub 2016 Sep 9.
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1328 Mapping the dynamics of Nrf2 antioxidant and NFB inflammatory responses by soft electrophilic chemicals in human liver cells defines the transition from adaptive to adverse responses. Toxicol In Vitro. 2022 Oct;84:105419. doi: 10.1016/j.tiv.2022.105419. Epub 2022 Jun 17.
1329 Low Autophagy (ATG) Gene Expression Is Associated with an Immature AML Blast Cell Phenotype and Can Be Restored during AML Differentiation Therapy. Oxid Med Cell Longev. 2018 Mar 18;2018:1482795. doi: 10.1155/2018/1482795. eCollection 2018.
1330 Inhibitory effect of PXR on ammonia-induced hepatocyte autophagy via P53. Toxicol Lett. 2018 Oct 1;295:153-161. doi: 10.1016/j.toxlet.2018.06.1066. Epub 2018 Jun 14.
1331 Vitamin D3 induces autophagy in human monocytes/macrophages via cathelicidin. Cell Host Microbe. 2009 Sep 17;6(3):231-43. doi: 10.1016/j.chom.2009.08.004.
1332 Chelation of lysosomal iron protects dopaminergic SH-SY5Y neuroblastoma cells from hydrogen peroxide toxicity by precluding autophagy and Akt dephosphorylation. Toxicol Sci. 2011 Oct;123(2):523-41. doi: 10.1093/toxsci/kfr179. Epub 2011 Jul 8.
1333 Combination treatment with arsenic trioxide and irradiation enhances cell-killing effects in human fibrosarcoma cells in vitro and in vivo through induction of both autophagy and apoptosis. Autophagy. 2010 Apr;6(3):353-65. doi: 10.4161/auto.6.3.11229. Epub 2010 Apr 11.
1334 Targeting multiple cannabinoid anti-tumour pathways with a resorcinol derivative leads to inhibition of advanced stages of breast cancer. Br J Pharmacol. 2014 Oct;171(19):4464-77. doi: 10.1111/bph.12803. Epub 2014 Sep 5.
1335 Riluzole induces AR degradation via endoplasmic reticulum stress pathway in androgen-dependent and castration-resistant prostate cancer cells. Prostate. 2019 Feb;79(2):140-150. doi: 10.1002/pros.23719. Epub 2018 Oct 2.
1336 Serum- and glucocorticoid-regulated kinase 2 determines drug-activated pregnane X receptor to induce gluconeogenesis in human liver cells. J Pharmacol Exp Ther. 2014 Jan;348(1):131-40. doi: 10.1124/jpet.113.209379. Epub 2013 Nov 7.
1337 High folic acid increases cell turnover and lowers differentiation and iron content in human HT29 colon cancer cells. Br J Nutr. 2008 Apr;99(4):703-8.
1338 Capsaicin inhibits cell proliferation by enhancing oxidative stress and apoptosis through SIRT1/NOX4 signaling pathways in HepG2 and HL-7702 cells. J Biochem Mol Toxicol. 2022 Mar;36(3):e22974. doi: 10.1002/jbt.22974. Epub 2021 Dec 23.
1339 Hesperetin relieves cisplatin-induced acute kidney injury by mitigating oxidative stress, inflammation and apoptosis. Chem Biol Interact. 2019 Aug 1;308:269-278.
1340 Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans. Pharmacogenomics J. 2014 Feb;14(1):35-40. doi: 10.1038/tpj.2013.3. Epub 2013 Feb 12.
1341 Combination of all-trans retinoic acid and taxol regressed glioblastoma T98G xenografts in nude mice. Apoptosis. 2007 Nov;12(11):2077-87. doi: 10.1007/s10495-007-0116-2. Epub 2007 Aug 16.
1342 Chloroquine has tumor-inhibitory and tumor-promoting effects in triple-negative breast cancer. Oncol Lett. 2013 Dec;6(6):1665-1672. doi: 10.3892/ol.2013.1602. Epub 2013 Oct 4.
1343 Antagonist-mediated down-regulation of Toll-like receptors increases the prevalence of human papillomavirus infection in systemic lupus erythematosus. Arthritis Res Ther. 2012 Apr 18;14(2):R80. doi: 10.1186/ar3803.
1344 DUOX expression in human keratinocytes and bronchial epithelial cells: Influence of vanadate. Toxicol In Vitro. 2018 Feb;46:257-264. doi: 10.1016/j.tiv.2017.10.010. Epub 2017 Oct 12.
1345 Endometrial receptivity is affected in women with high circulating progesterone levels at the end of the follicular phase: a functional genomics analysis. Hum Reprod. 2011 Jul;26(7):1813-25.
1346 Epigenetic influences of low-dose bisphenol A in primary human breast epithelial cells. Toxicol Appl Pharmacol. 2010 Oct 15;248(2):111-21.
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1349 Tumor suppressor gene inactivation during cadmium-induced malignant transformation of human prostate cells correlates with overexpression of de novo DNA methyltransferase. Environ Health Perspect. 2007 Oct;115(10):1454-9. doi: 10.1289/ehp.10207.
1350 The effect of dietary polyphenols on the epigenetic regulation of gene expression in MCF7 breast cancer cells. Toxicol Lett. 2010 Feb 1;192(2):119-25.
1351 Identification of troglitazone responsive genes: induction of RTP801 during troglitazone-induced apoptosis in Hep 3B cells. BMB Rep. 2010 Sep;43(9):599-603. doi: 10.5483/BMBRep.2010.43.9.599.
1352 Effect of quercetin on apoptosis of PANC-1 cells. J Korean Surg Soc. 2013 Dec;85(6):249-60. doi: 10.4174/jkss.2013.85.6.249. Epub 2013 Nov 26.
1353 Gene expression alteration during redox-dependent enhancement of arsenic cytotoxicity by emodin in HeLa cells. Cell Res. 2005 Jul;15(7):511-22.
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1355 Alcohol triggered bile acid disequilibrium by suppressing BSEP to sustain hepatocellular carcinoma progression. Chem Biol Interact. 2022 Apr 1;356:109847. doi: 10.1016/j.cbi.2022.109847. Epub 2022 Feb 9.
1356 Glucosamine-induced endoplasmic reticulum stress affects GLUT4 expression via activating transcription factor 6 in rat and human skeletal muscle cells. Diabetologia. 2010 May;53(5):955-65. doi: 10.1007/s00125-010-1676-1. Epub 2010 Feb 18.
1357 AMPK activator acadesine fails to alleviate isoniazid-caused mitochondrial instability in HepG2 cells. J Appl Toxicol. 2017 Oct;37(10):1219-1224. doi: 10.1002/jat.3483. Epub 2017 May 29.
1358 Advantageous use of HepaRG cells for the screening and mechanistic study of drug-induced steatosis. Toxicol Appl Pharmacol. 2016 Jul 1;302:1-9. doi: 10.1016/j.taap.2016.04.007. Epub 2016 Apr 16.
1359 A cardiac-specific robotized cellular assay identified families of human ligands as inducers of PGC-1 expression and mitochondrial biogenesis. PLoS One. 2012;7(10):e46753. doi: 10.1371/journal.pone.0046753. Epub 2012 Oct 3.
1360 Classification of heavy-metal toxicity by human DNA microarray analysis. Environ Sci Technol. 2007 May 15;41(10):3769-74.
1361 Analysis of the in vitro synergistic effect of 5-fluorouracil and cisplatin on cervical carcinoma cells. Int J Gynecol Cancer. 2006 May-Jun;16(3):1321-9.
1362 A new in vitro method for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells. Cutan Ocul Toxicol. 2010 Sep;29(3):171-92.
1363 Genome-Wide Analysis of Low Dose Bisphenol-A (BPA) Exposure in Human Prostate Cells. Curr Genomics. 2019 May;20(4):260-274. doi: 10.2174/1389202920666190603123040.
1364 Arginine methylation provides epigenetic transcription memory for retinoid-induced differentiation in myeloid cells. Mol Cell Biol. 2005 Jul;25(13):5648-63.
1365 Citrullination of RGG Motifs in FET Proteins by PAD4 Regulates Protein Aggregation and ALS Susceptibility. Cell Rep. 2018 Feb 6;22(6):1473-1483. doi: 10.1016/j.celrep.2018.01.031.
1366 Regulation of chromatin assembly and cell transformation by formaldehyde exposure in human cells. Environ Health Perspect. 2017 Sep 21;125(9):097019.
1367 Actinomycin D inhibits the expression of the cystine/glutamate transporter xCT via attenuation of CD133 synthesis in CD133(+) HCC. Chem Biol Interact. 2019 Aug 25;309:108713. doi: 10.1016/j.cbi.2019.06.026. Epub 2019 Jun 19.
1368 Translesion polymerase is upregulated by cancer therapeutics and confers anticancer drug resistance. Cancer Res. 2014 Oct 1;74(19):5585-96. doi: 10.1158/0008-5472.CAN-14-0953. Epub 2014 Aug 14.
1369 MiR-146a affects the alteration in myeloid differentiation induced by hydroquinone in human CD34(+) hematopoietic progenitor cells and HL-60 cells. Toxicol Res (Camb). 2016 Feb 16;5(3):848-858. doi: 10.1039/c5tx00419e. eCollection 2016 May 1.
1370 Arsenic and the epigenome: interindividual differences in arsenic metabolism related to distinct patterns of DNA methylation. J Biochem Mol Toxicol. 2013 Feb;27(2):106-15. doi: 10.1002/jbt.21462. Epub 2013 Jan 11.
1371 Analysis of estrogen agonism and antagonism of tamoxifen, raloxifene, and ICI182780 in endometrial cancer cells: a putative role for the epidermal growth factor receptor ligand amphiregulin. J Soc Gynecol Investig. 2005 Oct;12(7):e55-67.
1372 Folate deficiency induces cell-specific changes in the steady-state transcript levels of genes involved in folate metabolism and 1-carbon transfer reactions in human colonic epithelial cells. J Nutr. 2007 Mar;137(3):607-13. doi: 10.1093/jn/137.3.607.
1373 PARP inhibition induces Akt-mediated cytoprotective effects through the formation of a mitochondria-targeted phospho-ATM-NEMO-Akt-mTOR signalosome. Biochem Pharmacol. 2019 Apr;162:98-108. doi: 10.1016/j.bcp.2018.10.005. Epub 2018 Oct 6.
1374 Niclosamide, an anti-helminthic molecule, downregulates the retroviral oncoprotein Tax and pro-survival Bcl-2 proteins in HTLV-1-transformed T lymphocytes. Biochem Biophys Res Commun. 2015 Aug 14;464(1):221-228. doi: 10.1016/j.bbrc.2015.06.120. Epub 2015 Jun 23.
1375 Poly(ADP-ribose) polymerase 1 contributes to oxidative stress through downregulation of sirtuin 3 during cisplatin nephrotoxicity. Anat Cell Biol. 2016 Sep;49(3):165-176. doi: 10.5115/acb.2016.49.3.165. Epub 2016 Sep 29.
1376 Inactivation of cytochrome c oxidase by mutant SOD1s in mouse motoneuronal NSC-34 cells is independent from copper availability but is because of nitric oxide. J Neurochem. 2010 Jan;112(1):183-92. doi: 10.1111/j.1471-4159.2009.06441.x. Epub 2009 Oct 20.
1377 Impairment of mitochondrial anti-oxidant defence in SOD1-related motor neuron injury and amelioration by ebselen. Brain. 2006 Jul;129(Pt 7):1693-709. doi: 10.1093/brain/awl118. Epub 2006 May 15.
1378 Molecular pathways in the chemosensitization of cisplatin by quercetin in human head and neck cancer. Cancer Biol Ther. 2005 Sep;4(9):949-55.
1379 Functional characterization of N-octyl 4-methylamphetamine variants and related bivalent compounds at the dopamine and serotonin transporters using Ca(2+) channels as sensors. Toxicol Appl Pharmacol. 2021 May 15;419:115513. doi: 10.1016/j.taap.2021.115513. Epub 2021 Mar 27.
1380 Dopamine transporter gene associated with diminished subjective response to amphetamine. Neuropsychopharmacology. 2005 Mar;30(3):602-9. doi: 10.1038/sj.npp.1300637.
1381 Pharmacological Chaperones of the Dopamine Transporter Rescue Dopamine Transporter Deficiency Syndrome Mutations in Heterologous Cells. J Biol Chem. 2016 Oct 14;291(42):22053-22062. doi: 10.1074/jbc.M116.749119. Epub 2016 Aug 23.
1382 Evaluation of first generation synthetic cannabinoids on binding at non-cannabinoid receptors and in a battery of in?vivo assays in mice. Neuropharmacology. 2016 Nov;110(Pt A):143-153. doi: 10.1016/j.neuropharm.2016.07.016. Epub 2016 Jul 20.
1383 Pharmacological characterization of the aminorex analogs 4-MAR, 4,4'-DMAR, and 3,4-DMAR. Neurotoxicology. 2019 May;72:95-100. doi: 10.1016/j.neuro.2019.02.011. Epub 2019 Feb 15.
1384 Pyrethroid pesticide-induced alterations in dopamine transporter function. Toxicol Appl Pharmacol. 2006 Mar 15;211(3):188-97. doi: 10.1016/j.taap.2005.06.003. Epub 2005 Jul 11.
1385 Various concentrations of hesperetin induce different types of programmed cell death in human breast cancerous and normal cell lines in a ROS-dependent manner. Chem Biol Interact. 2023 Sep 1;382:110642. doi: 10.1016/j.cbi.2023.110642. Epub 2023 Jul 23.
1386 Oncoprotein SET dynamically regulates cellular stress response through nucleocytoplasmic transport in breast cancer. Cell Biol Toxicol. 2023 Aug;39(4):1795-1814. doi: 10.1007/s10565-022-09784-4. Epub 2022 Dec 19.
1387 Identification of potential biomarkers of hepatitis B-induced acute liver failure using hepatic cells derived from human skin precursors. Toxicol In Vitro. 2015 Sep;29(6):1231-9. doi: 10.1016/j.tiv.2014.10.012. Epub 2014 Oct 24.
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1389 A trichostatin A expression signature identified by TempO-Seq targeted whole transcriptome profiling. PLoS One. 2017 May 25;12(5):e0178302. doi: 10.1371/journal.pone.0178302. eCollection 2017.
1390 Identification and characterization of 3-iodothyronamine intracellular transport. Endocrinology. 2009 Apr;150(4):1991-9.
1391 Mitochondrial dysfunction induced by leflunomide and its active metabolite. Toxicology. 2018 Mar 1;396-397:33-45.
1392 Clarifying off-target effects for torcetrapib using network pharmacology and reverse docking approach. BMC Syst Biol. 2012 Dec 10;6:152.
1393 Isobaric tags for relative and absolute quantitation-based proteomics analysis of the effect of ginger oil on bisphenol A-induced breast cancer cell proliferation. Oncol Lett. 2021 Feb;21(2):101. doi: 10.3892/ol.2020.12362. Epub 2020 Dec 8.
1394 Comparative DNA microarray analysis of human monocyte derived dendritic cells and MUTZ-3 cells exposed to the moderate skin sensitizer cinnamaldehyde. Toxicol Appl Pharmacol. 2009 Sep 15;239(3):273-83.
1395 Sirt6 mediates antioxidative functions by increasing Nrf2 abundance. Exp Cell Res. 2023 Jan 1;422(1):113409. doi: 10.1016/j.yexcr.2022.113409. Epub 2022 Nov 7.
1396 Norcantharidin combined with paclitaxel induces endoplasmic reticulum stress mediated apoptotic effect in prostate cancer cells by targeting SIRT7 expression. Environ Toxicol. 2021 Nov;36(11):2206-2216. doi: 10.1002/tox.23334. Epub 2021 Jul 16.
1397 A human tRNA synthetase is a potent PARP1-activating effector target for resveratrol. Nature. 2015 Mar 19;519(7543):370-3. doi: 10.1038/nature14028. Epub 2014 Dec 22.
1398 Sirtuins are Unaffected by PARP Inhibitors Containing Planar Nicotinamide Bioisosteres. Chem Biol Drug Des. 2016 Mar;87(3):478-82. doi: 10.1111/cbdd.12680. Epub 2015 Nov 26.
1399 Oleanolic acid induces HCT116 colon cancer cell death through the p38/FOXO3a/Sirt6 pathway. Chem Biol Interact. 2022 Aug 25;363:110010. doi: 10.1016/j.cbi.2022.110010. Epub 2022 Jun 9.
1400 Reduction and scavenging of chemically reactive drug metabolites by NAD(P)H:quinone oxidoreductase 1 and NRH:quinone oxidoreductase 2 and variability in hepatic concentrations. Chem Res Toxicol. 2018 Feb 19;31(2):116-126.
1401 Aberrantly expressed genes in HaCaT keratinocytes chronically exposed to arsenic trioxide. Biomark Insights. 2011 Feb 8;6:7-16.
1402 Involvement of aryl hydrocarbon receptor in the cytotoxicity of corannulene and its derivatives. Toxicol Lett. 2020 Mar 15;321:114-121. doi: 10.1016/j.toxlet.2019.12.012. Epub 2019 Dec 9.
1403 Ameliorative effects of SLC22A2 gene polymorphism 808 G/T and cimetidine on cisplatin-induced nephrotoxicity in Chinese cancer patients. Food Chem Toxicol. 2012 Jul;50(7):2289-93. doi: 10.1016/j.fct.2012.03.077. Epub 2012 Apr 16.
1404 A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters. J Pharmacol Exp Ther. 2005 Oct;315(1):337-45.
1405 Transport of lamivudine [(-)-beta-L-2',3'-dideoxy-3'-thiacytidine] and high-affinity interaction of nucleoside reverse transcriptase inhibitors with human organic cation transporters 1, 2, and 3. J Pharmacol Exp Ther. 2009 Apr;329(1):252-61. doi: 10.1124/jpet.108.146225. Epub 2009 Jan 13.
1406 Interactions of human organic anion transporters and human organic cation transporters with nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther. 2002 Nov;303(2):534-9.
1407 Expression of drug transporters and drug metabolizing enzymes in the bladder urothelium in man and affinity of the bladder spasmolytic trospium chloride to transporters likely involved in its pharmacokinetics. Mol Pharm. 2015 Jan 5;12(1):171-8.
1408 Expression and pharmacological profile of the human organic cation transporters hOCT1, hOCT2 and hOCT3. Br J Pharmacol. 2002 Jul;136(6):829-36.
1409 Quercetin inhibits hydrogen peroxide-induced DNA damage and enhances DNA repair in Caco-2 cells. Food Chem Toxicol. 2009 Nov;47(11):2716-22. doi: 10.1016/j.fct.2009.07.033. Epub 2009 Aug 3.
1410 Differences in the activities of resveratrol and ascorbic acid in protection of ethanol-induced oxidative DNA damage in human peripheral lymphocytes. Food Chem Toxicol. 2012 Feb;50(2):168-74.
1411 Higher Concentrations of Folic Acid Cause Oxidative Stress, Acute Cytotoxicity, and Long-Term Fibrogenic Changes in Kidney Epithelial Cells. Chem Res Toxicol. 2022 Nov 21;35(11):2168-2179. doi: 10.1021/acs.chemrestox.2c00258. Epub 2022 Nov 10.
1412 DNA demethylation by 5-aza-2-deoxycytidine treatment abrogates 17 beta-estradiol-induced cell growth and restores expression of DNA repair genes in human breast cancer cells. Cancer Lett. 2012 Mar;316(1):62-9. doi: 10.1016/j.canlet.2011.10.022. Epub 2011 Oct 23.
1413 Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington's disease. Brain. 2011 Jan;134(Pt 1):119-36. doi: 10.1093/brain/awq278. Epub 2010 Oct 7.
1414 Characterization of cellular protective effects of ATP13A2/PARK9 expression and alterations resulting from pathogenic mutants. J Neurosci Res. 2012 Dec;90(12):2306-16. doi: 10.1002/jnr.23112. Epub 2012 Jul 30.
1415 Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297. doi: 10.1016/j.fct.2020.111297. Epub 2020 Mar 28.
1416 Down-regulation of HER-2 expression in human breast cancer cell HBC-4 and ZR75-1 by nitrogen-mustard-N-oxide. Kobe J Med Sci. 2007;53(4):135-42.
1417 Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
1418 Epidermal growth factor receptor activity determines response of colorectal cancer cells to gefitinib alone and in combination with chemotherapy. Clin Cancer Res. 2005 Oct 15;11(20):7480-9. doi: 10.1158/1078-0432.CCR-05-0328.
1419 The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat Genet. 2009 Feb;41(2):178-186.
1420 The influence of curcumin, quercetin, and eicosapentaenoic acid on the expression of phase II detoxification enzymes in the intestinal cell lines HT-29, Caco-2, HuTu 80, and LT97. Nutr Cancer. 2012 Aug;64(6):856-63.
1421 Knockdown of the gene for homeobox protein HOXB13 reduces toxicity of oxidative-stress inducers in HEK293 cells. J Toxicol Sci. 2013;38(6):821-2. doi: 10.2131/jts.38.821.
1422 Geraniol suppresses prostate cancer growth through down-regulation of E2F8. Cancer Med. 2016 Oct;5(10):2899-2908.
1423 Stress-regulated translational attenuation adapts mitochondrial protein import through Tim17A degradation. Cell Metab. 2013 Dec 3;18(6):908-19. doi: 10.1016/j.cmet.2013.11.006.
1424 Mechanistic basis for overcoming platinum resistance using copper chelating agents. Mol Cancer Ther. 2012 Nov;11(11):2483-94. doi: 10.1158/1535-7163.MCT-12-0580. Epub 2012 Aug 21.
1425 Regulation of the high-affinity copper transporter (hCtr1) expression by cisplatin and heavy metals. J Biol Inorg Chem. 2014 Jan;19(1):17-27. doi: 10.1007/s00775-013-1051-z. Epub 2013 Oct 17.
1426 Selenoprotein H suppresses cellular senescence through genome maintenance and redox regulation. J Biol Chem. 2014 Dec 5;289(49):34378-88. doi: 10.1074/jbc.M114.611970. Epub 2014 Oct 21.
1427 Transcriptome and DNA methylation changes modulated by sulforaphane induce cell cycle arrest, apoptosis, DNA damage, and suppression of proliferation in human liver cancer cells. Food Chem Toxicol. 2020 Feb;136:111047. doi: 10.1016/j.fct.2019.111047. Epub 2019 Dec 12.