Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWX5CO)

• Drug Name: Nicotine Drug Info
• Synonyms: Habitrol; Micotine; NCT; NICOTINE AND SALTS; Nicoderm Patch; Nicotina [Italian]; Nicotine Patch; Nicotine [USAN]; Nicotine replacement patch; Nicotine solution; Nictoine patch; Nikotin [German]; Nikotyna [Polish]; Transdermal Nicotine; Nicotine [UN1654] [Poison]; ENT 3,424; Habitrol (TN); Nicorette (TN); Nicotine (USP); Nicotine (compounds related to); Nicotine [BSI:ISO]; L(-)-nicotine; Beta-Pyridyl-alpha-N-methyl pyrrolidine; (-)-Nicotine solution; (2S) 3-(1-Methyl-pyrrolidin-2-yl)-pyridine; (S)-(-)-NICOTINE, 3-[(2S)-1-METHYL-2-PYRROLIDINYL] PYRIDINE; (S)-(-)-Nicotine; (S)-3-(1-methylpyrrolidin-2-yl)pyridine; (S)-3-(N-methylpyrrolidin-2-yl)pyridine; (S)-Nicotine; 3-(2-(N-methylpyrrolidinyl))pyridine; 3-(N-Methylpyrollidino)pyridine; 3-(N-Methylpyrrolidino)pyridine; 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine

Indication

Disease Entry	ICD 11	Status	REF
Lung cancer	2C25.0	Approved	[1]
Nicotine dependence	6C4A.2	Approved	[2]
Pellagra		Approved	[1]
Tobacco dependence	6C4A.2	Clinical trial	[3]

• Cross-matching ID:
  PubChem CID: 89594
  ChEBI ID: CHEMBL3
  CAS Number: CAS 54-11-5
  TTD Drug ID: DMWX5CO
  VARIDT Drug ID: DR00679
  INTEDE Drug ID: DR1148

Molecule-Related Drug Atlas

Drug(s) Targeting Nicotinic acetylcholine receptor (nAChR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cotinine	DMCEZ1B	Insecticide	N.A.	Approved	[16]
Pancuronium	DMB0VY8	Anaesthesia	9A78.6	Approved	[17]
Atracurium	DM42HXN	Anaesthesia	9A78.6	Approved	[17]
Mecamylamine	DMGQFYB	Essential hypertension	BA00	Approved	[18]
CYTISINE	DMUF0BJ	Tobacco dependence	6C4A.2	Phase 3	[3]
Dexefaroxan	DMTY4KN	Parkinson disease	8A00.0	Phase 2	[19]
BMS-954561	DM7XV4R	Diabetic neuropathy	8C0Z	Phase 2	[20]
ASM-024	DM35S2I	Asthma	CA23	Phase 2	[21]
NIC-002	DMKLJMI	Nicotine dependence	6C4A.2	Phase 2	[22]
TRIDMAC	DMWU41P	Mood disorder	6A60-6E23	Phase 2	[23]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[24]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[25]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[26]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[28]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[29]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[30]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[31]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[25]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[32]

Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[33]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[34]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[35]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[36]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[37]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[30]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[39]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[40]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[41]

Drug(s) Metabolized By UDP-glucuronosyltransferase 1A1 (UGT1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[42]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[45]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[48]
Metronidazole	DMTIVEN	Abscess		Approved	[49]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[50]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[51]

Drug(s) Metabolized By Cytochrome P450 2A6 (CYP2A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[33]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[52]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[53]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[28]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Metronidazole	DMTIVEN	Abscess		Approved	[55]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[56]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[52]

Drug(s) Metabolized By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[57]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[58]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[59]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[60]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[39]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[61]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[62]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[63]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[64]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[65]

Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[66]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[67]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[68]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[28]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[32]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[69]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[70]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[71]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[72]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[73]

Drug(s) Metabolized By Cytochrome P450 2E1 (CYP2E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[74]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[75]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[53]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[76]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[77]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[39]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[52]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[78]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[79]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[80]

Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[33]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[81]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[81]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[52]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[82]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[83]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[84]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[81]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[85]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[56]

Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[86]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[87]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[88]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[52]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[89]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[52]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[90]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[91]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[93]

Drug(s) Metabolized By Cytochrome P450 2B6 (CYP2B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[94]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[52]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[95]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[96]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[97]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[98]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[99]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]

Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[101]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[86]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[102]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[103]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[52]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[104]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[93]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[105]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[56]

Drug(s) Metabolized By Cytochrome P450 2A13 (CYP2A13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone cypionate	DMC1TEV	N. A.	N. A.	Approved	[106]
Phenacetin	DMRQAM0	Analgesia	MB40.8	Withdrawn from market	[107]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[108]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[109]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[110]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[111]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[112]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[113]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[114]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[115]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[113]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[116]

Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[117]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[118]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[119]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[120]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[121]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[122]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[123]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[124]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[125]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[126]

Drug(s) Affected By Regulatory factor X-associated protein (RFXAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[133]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[136]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase alpha (PTPRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Mecamylamine	DMGQFYB	Essential hypertension	BA00	Approved	[139]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[127]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[140]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[141]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[136]

Drug(s) Affected By Ras-related protein Rab-6A (RAB6A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Risedronate	DM5FLTY	Bone Paget disease		Approved	[143]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[144]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[141]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[142]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[147]

Drug(s) Affected By Tissue factor pathway inhibitor 2 (TFPI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[148]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[149]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[152]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]

Drug(s) Affected By Rho guanine nucleotide exchange factor 7 (ARHGEF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[154]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[155]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[156]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[157]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[127]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[158]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[159]

Drug(s) Affected By E3 ubiquitin-protein ligase RBBP6 (RBBP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[160]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Selenium	DM25CGV	N. A.	N. A.	Approved	[161]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[162]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[163]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]

Drug(s) Affected By Histone-lysine N-methyltransferase 2C (KMT2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[165]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[167]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[168]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[169]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]

Drug(s) Affected By Fasciculation and elongation protein zeta-1 (FEZ1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[171]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[148]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[173]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[155]
Mecamylamine	DMGQFYB	Essential hypertension	BA00	Approved	[139]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[152]

Drug(s) Affected By Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[161]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[174]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[163]
Mecamylamine	DMGQFYB	Essential hypertension	BA00	Approved	[139]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[152]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]

Drug(s) Affected By Copper chaperone for superoxide dismutase (CCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[123]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[175]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[176]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[177]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]

Drug(s) Affected By Amyloid-beta precursor protein (APP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[178]
Selenium	DM25CGV	N. A.	N. A.	Approved	[161]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[179]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[180]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[181]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[182]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[183]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[184]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[186]

Drug(s) Affected By Syntaxin-binding protein 3 (STXBP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[187]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[155]
SEROTONIN	DMOFCRY	Discovery agent	N.A.	Investigative	[188]

Drug(s) Affected By Segment polarity protein dishevelled homolog DVL-2 (DVL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[189]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[191]
Calphostin C	DM9X2D0	N. A.	N. A.	Terminated	[192]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[193]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[194]

Drug(s) Affected By Chromodomain-helicase-DNA-binding protein 2 (CHD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[195]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[196]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Bortezomib	DMNO38U	Leukemia		Approved	[144]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[197]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[141]

Drug(s) Affected By UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Bortezomib	DMNO38U	Leukemia		Approved	[144]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[127]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[199]

Drug(s) Affected By Apoptosis regulatory protein Siva (SIVA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[200]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[201]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[201]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[202]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[202]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[202]
Bortezomib	DMNO38U	Leukemia		Approved	[203]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]

Drug(s) Affected By Cytoplasmic dynein 1 light intermediate chain 2 (DYNC1LI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[174]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[204]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[205]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[127]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[142]

Drug(s) Affected By E3 ubiquitin-protein ligase parkin (PRKN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Emtricitabine	DMBMUWZ	Hepatitis virus infection	1E50-1E51	Approved	[206]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[207]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[208]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[209]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[210]
Methamphetamine	DMPM4SK	Anxiety		Approved	[211]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[212]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[158]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]

Drug(s) Affected By C-Jun-amino-terminal kinase-interacting protein 4 (SPAG9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[165]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[159]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[141]

Drug(s) Affected By Serine protease 1 (PRSS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[213]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[214]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[150]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[215]
Coprexa	DMA0WEK	Neurological disorder	6B60	Phase 3	[216]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[217]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]

Drug(s) Affected By Laminin subunit beta-1 (LAMB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[218]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[152]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[219]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[220]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[221]

Drug(s) Affected By Myb-related protein B (MYBL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[178]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[222]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[223]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[224]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[149]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[201]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[223]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[225]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[226]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]

Drug(s) Affected By Complement component C7 (C7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[207]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[227]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[228]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[159]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[229]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[230]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[187]

Drug(s) Affected By Nucleoprotein TPR (TPR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[231]
Selenium	DM25CGV	N. A.	N. A.	Approved	[161]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[165]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[205]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[205]

Drug(s) Affected By Glucosidase 2 subunit beta (PRKCSH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[232]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[233]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[234]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[147]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[147]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[235]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[187]

Drug(s) Affected By Creatine kinase S-type, mitochondrial (CKMT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[236]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[237]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[238]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[239]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[230]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[236]

Drug(s) Affected By Interferon-induced, double-stranded RNA-activated protein kinase (EIF2AK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[161]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[240]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[241]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[131]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[242]

Drug(s) Affected By Cellular retinoic acid-binding protein 2 (CRABP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[243]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[177]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[244]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[148]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[149]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[245]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[246]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]

Drug(s) Affected By Stress-induced-phosphoprotein 1 (STIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[247]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[248]
Haloperidol	DM96SE0	Delirium		Approved	[205]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[207]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[205]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[205]
Mecamylamine	DMGQFYB	Essential hypertension	BA00	Approved	[207]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[249]

Drug(s) Affected By Cyclin-dependent kinases regulatory subunit 2 (CKS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[161]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[181]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[224]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[250]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[201]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[201]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[173]

Drug(s) Affected By Patatin-like phospholipase domain-containing protein 4 (PNPLA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[179]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[141]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[161]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[236]

Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[200]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[251]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[252]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[253]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[254]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]

Drug(s) Affected By Transcriptional regulator ATRX (ATRX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
Selenium	DM25CGV	N. A.	N. A.	Approved	[161]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[256]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[131]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[173]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[257]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[258]

Drug(s) Affected By Translation initiation factor IF-2, mitochondrial (MTIF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[158]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[159]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[259]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[259]
Josamycin	DMKJ8LB	Bacterial infection	1A00-1C4Z	Approved	[259]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[260]

Drug(s) Affected By F-actin-capping protein subunit alpha-2 (CAPZA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[196]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[154]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[199]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[261]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[262]

Drug(s) Affected By RNA-binding protein 25 (RBM25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[161]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[165]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[155]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[199]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[141]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[141]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[161]

Drug(s) Affected By DNA ligase 4 (LIG4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[250]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[131]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[257]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[263]
Bortezomib	DMNO38U	Leukemia		Approved	[144]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[264]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[136]
Fenfluramine	DM0762O	Dravet syndrome	8A61.11	Phase 3	[265]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]

Drug(s) Affected By Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 (GNG10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[200]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[266]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[230]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[148]

Drug(s) Affected By Serpin H1 (SERPINH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[267]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[268]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[144]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[168]

Drug(s) Affected By H(+)/Cl(-) exchange transporter 3 (CLCN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
Selenium	DM25CGV	N. A.	N. A.	Approved	[161]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[269]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]

Drug(s) Affected By Protein FosB (FOSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[270]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[269]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[196]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[271]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[149]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[272]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[273]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[274]

Drug(s) Affected By Protein transport protein Sec61 subunit gamma (SEC61G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[275]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[149]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[127]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[217]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[276]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[136]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[194]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[277]

Drug(s) Affected By Myosin light polypeptide 6 (MYL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[161]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[278]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[131]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[168]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[127]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[217]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[276]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[279]

Drug(s) Affected By CMP-sialic acid transporter (SLC35A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[280]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[280]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[281]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[282]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[277]

Drug(s) Affected By Centromere-associated protein E (CENPE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[231]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[181]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[201]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[201]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[283]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[219]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha (PPP2R3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[252]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[284]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[158]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[276]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[285]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[286]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[161]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]

Drug(s) Affected By Phosphatidylinositol-glycan biosynthesis class F protein (PIGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[141]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[287]

Drug(s) Affected By Son of sevenless homolog 1 (SOS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
Selenium	DM25CGV	N. A.	N. A.	Approved	[161]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[288]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[149]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[289]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[130]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[173]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[207]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]

Drug(s) Affected By Zinc finger protein Rlf (RLF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[202]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[202]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[202]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[159]

Drug(s) Affected By Chromobox protein homolog 3 (CBX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[290]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[290]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[155]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[290]
Bortezomib	DMNO38U	Leukemia		Approved	[144]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]

Drug(s) Affected By Origin recognition complex subunit 2 (ORC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[266]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[291]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[142]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[230]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[191]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[155]

Drug(s) Affected By Zinc transporter ZIP6 (SLC39A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[292]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[148]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[293]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[294]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[295]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[292]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]

Drug(s) Affected By Golgin subfamily A member 4 (GOLGA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[173]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[207]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[257]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Mecamylamine	DMGQFYB	Essential hypertension	BA00	Approved	[207]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[296]

Drug(s) Affected By Serine incorporator 3 (SERINC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[136]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[161]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[191]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[155]

Drug(s) Affected By Transformer-2 protein homolog alpha (TRA2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[205]
Selenium	DM25CGV	N. A.	N. A.	Approved	[161]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[214]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[165]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[150]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[131]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]

Drug(s) Affected By Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[297]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[298]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[299]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[269]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]

Drug(s) Affected By Thyroid receptor-interacting protein 11 (TRIP11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[257]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[159]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[191]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[277]

Drug(s) Affected By Serine/threonine-protein kinase N2 (PKN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[161]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[165]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[227]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Ximelegatran	DMU8ANS	Myocardial infarction	BA41-BA43	Approved	[300]

Drug(s) Affected By DNA damage-binding protein 1 (DDB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[301]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[302]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[303]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[304]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[305]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[159]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[154]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[306]

Drug(s) Affected By NADH dehydrogenase 1 alpha subcomplex subunit 5 (NDUFA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[199]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]
Fenretinide	DMRD5SP	Macular degeneration	9B78.3	Phase 3	[307]
biochanin A	DM0HPWY	Discovery agent	N.A.	Investigative	[308]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[309]

Drug(s) Affected By Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[236]
Selenium	DM25CGV	N. A.	N. A.	Approved	[161]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[310]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[250]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[155]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]

Drug(s) Affected By Transmembrane protein 41B (TMEM41B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[269]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Bortezomib	DMNO38U	Leukemia		Approved	[144]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[311]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[154]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]

Drug(s) Affected By Heterochromatin protein 1-binding protein 3 (HP1BP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[312]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[313]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[144]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[158]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[314]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[262]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]

Drug(s) Affected By Pre-mRNA-splicing factor 38B (PRPF38B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[191]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[194]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[277]

Drug(s) Affected By Serine/threonine-protein kinase TAO1 (TAOK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[165]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[202]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[202]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[202]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[217]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[141]

Drug(s) Affected By Ninein (NIN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[315]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[202]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[202]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[202]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[207]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[202]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[202]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]

Drug(s) Affected By Tribbles homolog 2 (TRIB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[161]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[316]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[284]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[317]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[159]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[318]

Drug(s) Affected By DNA topoisomerase 2-binding protein 1 (TOPBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[181]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[201]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[201]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[155]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[199]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[159]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[319]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[154]

Drug(s) Affected By PHD finger protein 3 (PHF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[161]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[191]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[130]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[173]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[257]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[320]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[276]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[161]

Drug(s) Affected By Probable ATP-dependent RNA helicase DDX17 (DDX17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Selenium	DM25CGV	N. A.	N. A.	Approved	[161]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[321]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[322]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[202]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[202]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[131]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]

Drug(s) Affected By DNA repair protein RAD50 (RAD50)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[323]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[324]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[173]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[257]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]

Drug(s) Affected By snRNA-activating protein complex subunit 3 (SNAPC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[325]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[326]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[148]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[230]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[327]

Drug(s) Affected By PHD finger protein 21A (PHF21A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[149]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[237]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[320]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[281]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[141]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[136]

Drug(s) Affected By THO complex subunit 1 (THOC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[201]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[201]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[328]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[329]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[262]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[191]

Drug(s) Affected By Chloride channel CLIC-like protein 1 (CLCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[161]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[330]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[161]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[191]

Drug(s) Affected By Protein SCAF11 (SCAF11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[165]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[245]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[173]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[257]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[155]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[159]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[331]

Drug(s) Affected By Mediator of RNA polymerase II transcription subunit 28 (MED28)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[174]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[159]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[230]
Forskolin	DM6ITNG	Solid tumour/cancer	2A00-2F9Z	Investigative	[332]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[333]
[3H]methyltrienolone	DMTSGOW	Discovery agent	N.A.	Investigative	[332]

Drug(s) Affected By Arginine and glutamate-rich protein 1 (ARGLU1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[160]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[334]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[174]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[155]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[304]

Drug(s) Affected By DDB1- and CUL4-associated factor 16 (DCAF16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[335]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[230]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[336]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[148]

Drug(s) Affected By Polypyrimidine tract-binding protein 2 (PTBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[123]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[245]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[284]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[304]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]

Drug(s) Affected By Splicing factor 3B subunit 6 (SF3B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[262]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[230]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[194]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[277]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[155]

Drug(s) Affected By Protein PRRC2C (PRRC2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[236]
Selenium	DM25CGV	N. A.	N. A.	Approved	[161]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[322]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[131]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[337]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[338]
Fructose	DM43AN2	Vomiting	MD90	Approved	[339]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[340]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[111]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[275]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[341]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[342]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[343]

Drug(s) Affected By Beta-2 adrenergic receptor (ADRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salmeterol	DMIEU69	Allergic asthma	CA23.0	Approved	[344]
Bambuterol	DMKLSHF	Asthma	CA23	Approved	[345]
Terbutaline	DMD4381	Asthma	CA23	Approved	[346]
Salbutamol	DMN9CWF	Acute asthma	CA23	Approved	[347]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[348]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[174]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[349]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[350]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[351]

Drug(s) Affected By Beta-1 adrenergic receptor (ADRB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dobutamine	DMD1B8Z	Heart failure	BD10-BD13	Approved	[352]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[353]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[174]
Vortioxetine	DM6F1PU	Major depressive disorder	6A70.3	Approved	[354]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[155]
Labetalol	DMK8U72	Hypertension	BA00-BA04	Approved	[355]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[356]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[357]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]

Drug(s) Affected By Deoxyribonuclease-2-alpha (DNASE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[358]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[163]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[280]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[168]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[158]

Drug(s) Affected By NF-kappa-B inhibitor epsilon (NFKBIE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[359]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[360]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[361]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Bortezomib	DMNO38U	Leukemia		Approved	[362]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[363]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[127]

Drug(s) Affected By Serine/threonine-protein kinase 25 (STK25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[247]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[236]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[14]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[230]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[236]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[364]

Drug(s) Affected By Krueppel-like factor 11 (KLF11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[214]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[149]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[150]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[252]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[365]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[144]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]

Drug(s) Affected By C-C motif chemokine 16 (CCL16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[331]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[14]

Drug(s) Affected By Death effector domain-containing protein (DEDD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[161]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[366]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[367]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[156]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[317]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[161]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[368]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[14]

Drug(s) Affected By DNA fragmentation factor subunit beta (DFFB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[369]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[370]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[126]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[371]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[201]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[201]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[131]

Drug(s) Affected By Interferon alpha-inducible protein 6 (IFI6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[200]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[357]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[372]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[231]
Selenium	DM25CGV	N. A.	N. A.	Approved	[161]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[373]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[374]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[373]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[371]

Drug(s) Affected By C-C motif chemokine 5 (CCL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[341]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[375]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[376]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[179]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[377]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[181]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[378]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[379]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[380]

Drug(s) Affected By CD59 glycoprotein (CD59)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[200]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[381]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[382]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[201]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[201]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]

Drug(s) Affected By POU domain, class 2, transcription factor 1 (POU2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[383]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[384]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[157]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[383]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[157]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[14]

Drug(s) Affected By Ezrin (EZR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[205]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Selenium	DM25CGV	N. A.	N. A.	Approved	[161]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[385]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[148]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[386]
Haloperidol	DM96SE0	Delirium		Approved	[205]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[130]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[339]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[387]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[388]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[174]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[389]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[390]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[370]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[391]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[392]

Drug(s) Affected By Transcription factor BTF3 (BTF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[142]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[393]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[14]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[230]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[191]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[309]

Drug(s) Affected By E3 ubiquitin-protein ligase CBL (CBL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[394]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[149]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[131]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[163]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[157]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[168]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]

Drug(s) Affected By Nuclear transcription factor Y subunit beta (NFYB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[221]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[159]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[276]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[142]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[14]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[230]

Drug(s) Affected By Pentraxin-related protein PTX3 (PTX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[395]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[396]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[155]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[219]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[220]
Bortezomib	DMNO38U	Leukemia		Approved	[360]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]

Drug(s) Affected By Hepatocyte growth factor-like protein (MST1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[397]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[128]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[295]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[281]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[141]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[398]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[14]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[399]

Drug(s) Affected By Interleukin-3 receptor subunit alpha (IL3RA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[400]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[401]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[136]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[14]
Tacedinaline	DM1Z74X	Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 2	[400]

Drug(s) Affected By Embryonic growth/differentiation factor 1 (GDF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[402]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[149]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[403]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[404]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[14]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[230]
PHENCYCLIDINE	DMQBEYX	Discovery agent	N.A.	Investigative	[405]

Drug(s) Affected By Proteasome subunit beta type-6 (PSMB6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[406]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[407]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[245]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[158]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]
Ardeparin	DMYRX8B	Deep vein thrombosis	BD71	Approved	[408]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[409]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[161]

Drug(s) Affected By cAMP-dependent protein kinase type II-beta regulatory subunit (PRKAR2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[227]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[410]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[158]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[295]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[411]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[412]

Drug(s) Affected By Receptor-type tyrosine-protein kinase FLT3 (FLT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[413]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[414]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[236]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[415]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[416]
Venetoclax	DM8I94Y	Chronic lymphocytic leukaemia	2A82.0	Approved	[417]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[418]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[419]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[420]

Drug(s) Affected By Alpha-synuclein (SNCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[263]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[421]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Bortezomib	DMNO38U	Leukemia		Approved	[422]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[423]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[280]

Drug(s) Affected By Breast cancer type 1 susceptibility protein (BRCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[424]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[425]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[426]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[427]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[385]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[428]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[429]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[181]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]

Drug(s) Affected By Kappa-type opioid receptor (OPRK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[430]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[227]
Morphine	DMRMS0L	Advanced cancer	2A00-2F9Z	Approved	[431]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[148]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[339]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[141]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[236]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[432]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[433]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[434]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[435]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[324]
Fructose	DM43AN2	Vomiting	MD90	Approved	[436]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[437]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[438]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[439]

Drug(s) Affected By Signal transducer and activator of transcription 2 (STAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[358]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[440]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[441]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[159]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[281]

Drug(s) Affected By Protein S100-A10 (S100A10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[148]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[442]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[443]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[201]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[201]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[444]

Drug(s) Affected By Cyclin-dependent kinases regulatory subunit 1 (CKS1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[445]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[181]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[386]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[201]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[201]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[219]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[232]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]

Drug(s) Affected By Large ribosomal subunit protein eL8 (RPL7A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[205]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[233]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[446]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[147]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[14]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[147]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[194]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[447]

Drug(s) Affected By Small ribosomal subunit protein eS25 (RPS25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[161]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[304]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[233]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[279]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[14]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[309]

Drug(s) Affected By Transcription elongation factor SPT4 (SUPT4H1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[280]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[280]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[161]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[314]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[14]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[277]

Drug(s) Affected By Protein CBFA2T1 (RUNX1T1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[245]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[320]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[141]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[148]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[148]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[161]
Tanespimycin	DMNLQHK	Breast cancer	2C60-2C65	Phase 2	[448]

Drug(s) Affected By Regulator of G-protein signaling 1 (RGS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[179]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[449]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[450]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[155]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[451]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[452]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[453]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[311]

Drug(s) Affected By Nucleoside diphosphate kinase 3 (NME3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[163]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[454]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[154]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[136]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[455]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[393]

Drug(s) Affected By Transcription factor Dp-1 (TFDP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[456]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[389]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[224]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[163]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[457]

Drug(s) Affected By Helicase-like transcription factor (HLTF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[370]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[370]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[458]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[159]

Drug(s) Affected By Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[174]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[128]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[311]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[14]

Drug(s) Affected By Cocaine- and amphetamine-regulated transcript protein (CARTPT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[459]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[403]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[141]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]

Drug(s) Affected By POU domain class 2-associating factor 1 (POU2AF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[223]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[150]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[223]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[460]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[461]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[462]

Drug(s) Affected By Anti-Muellerian hormone type-2 receptor (AMHR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[463]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[421]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[280]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[14]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[230]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[464]
PHENCYCLIDINE	DMQBEYX	Discovery agent	N.A.	Investigative	[405]

Drug(s) Affected By Serine/threonine-protein kinase LMTK1 (AATK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[236]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[163]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[281]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[136]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[465]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[466]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[230]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[191]

Drug(s) Affected By MAP kinase-activating death domain protein (MADD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[374]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[196]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[163]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[367]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[467]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[454]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[136]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[404]

Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[468]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[469]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[200]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[470]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[471]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[472]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[473]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[126]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[391]

Drug(s) Affected By Prothrombin (F2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[474]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[179]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[475]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[213]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[224]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[476]
Phytonadione	DM8HDOL	Bleeding disorder	GA20-GA21	Approved	[477]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[478]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[479]

Drug(s) Affected By Transcription factor JunB (JUNB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[111]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[480]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[149]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[481]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[482]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[483]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[160]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[341]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[484]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[485]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[486]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[487]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[488]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[489]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[490]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[491]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[492]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[488]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[493]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[494]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[495]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[496]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[445]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[497]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[498]

Drug(s) Affected By Signal transducer and activator of transcription 5B (STAT5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[499]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[500]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[196]
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[501]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[502]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[503]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[157]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[504]

Drug(s) Affected By Metalloproteinase inhibitor 1 (TIMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pentoxifylline	DMU3DNC	Alcoholic hepatitis	DB94.1	Approved	[339]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[505]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[506]
Selenium	DM25CGV	N. A.	N. A.	Approved	[507]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[506]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[508]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[509]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[510]

Drug(s) Affected By Metalloproteinase inhibitor 3 (TIMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[507]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[511]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[385]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[512]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[269]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[126]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[252]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]

Drug(s) Affected By Metalloproteinase inhibitor 4 (TIMP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[507]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[513]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[410]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[280]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[411]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[514]

Drug(s) Affected By Matrilysin (MMP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[385]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[515]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[516]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[517]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[450]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[518]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[519]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[520]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[521]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[522]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[523]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[524]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[525]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[526]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[527]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[528]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[148]

Drug(s) Affected By Transcription factor E2F1 (E2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[529]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[424]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[530]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[531]
Selenium	DM25CGV	N. A.	N. A.	Approved	[161]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[490]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[532]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[533]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[181]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[534]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[340]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[535]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[536]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[342]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[389]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[537]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[538]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[342]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[539]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 2 (BIRC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[540]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[469]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[541]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[542]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[543]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[397]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[544]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[545]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[546]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[547]

Drug(s) Affected By Steroidogenic acute regulatory protein, mitochondrial (STAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[548]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[237]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[131]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[549]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[550]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[175]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[551]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[284]

Drug(s) Affected By Zinc finger protein SNAI2 (SNAI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[523]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[552]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[148]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[310]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[201]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[201]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[245]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]

Drug(s) Affected By Zinc finger protein SNAI1 (SNAI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[480]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[523]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[552]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[553]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[554]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[555]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[556]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[130]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[557]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[558]

Drug(s) Affected By POU domain, class 5, transcription factor 1 (POU5F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[552]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[559]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[560]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[148]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[397]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[561]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[562]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[237]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[563]

Drug(s) Affected By Homeobox protein NANOG (NANOG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[564]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[552]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[559]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[560]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[148]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[397]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[561]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[562]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[565]

Drug(s) Affected By Insulin-induced gene 1 protein (INSIG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[231]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[298]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[365]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[374]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[566]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[269]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[374]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[196]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[201]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[202]

Drug(s) Affected By Cyclin-G2 (CCNG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[567]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[299]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[148]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[567]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[252]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[202]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[202]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[131]

Drug(s) Affected By Ankyrin repeat and BTB/POZ domain-containing protein 3 (ABTB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[152]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[168]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[158]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[148]

Drug(s) Affected By Envoplakin-like protein (EVPLL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[295]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[281]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[568]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[569]

Drug(s) Affected By Stearoyl-CoA desaturase (SCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[570]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[571]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[571]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[179]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[272]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[571]
Fructose	DM43AN2	Vomiting	MD90	Approved	[572]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[571]

Drug(s) Affected By Leucine-rich repeat transmembrane protein FLRT2 (FLRT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[245]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[284]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[573]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[295]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[331]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[574]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[154]

Drug(s) Affected By Ephrin-A2 (EFNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[245]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[320]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[281]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[136]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[230]

Drug(s) Affected By Sushi repeat-containing protein SRPX2 (SRPX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[365]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[269]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[245]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[284]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[410]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]

Drug(s) Affected By Kinesin-like protein KIF21B (KIF21B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[299]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[214]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[131]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[299]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[575]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[168]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[295]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[281]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]

Drug(s) Affected By Immunoglobulin superfamily member 3 (IGSF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[450]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[245]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[280]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[280]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[411]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]

Drug(s) Affected By Gamma-glutamylcyclotransferase (GGCT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[273]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[335]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[409]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[230]

Drug(s) Affected By Mediator of RNA polymerase II transcription subunit 24 (MED24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[161]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[191]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[335]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[393]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[191]

Drug(s) Affected By CCN family member 5 (CCN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[480]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[181]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[373]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[373]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[373]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[295]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[576]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[577]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[276]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[578]

Drug(s) Affected By 2'-5'-oligoadenylate synthase 1 (OAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[373]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[579]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[373]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[269]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[386]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[371]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[150]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[201]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[130]

Drug(s) Affected By Keratin, type II cytoskeletal 6B (KRT6B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[580]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[450]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[217]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[577]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[261]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[465]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]
PD-153035	DM7KJTI	Psoriasis vulgaris	EA90	Discontinued in Phase 1	[580]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[581]

Drug(s) Affected By Metallothionein-1E (MT1E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[270]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[370]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[582]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[130]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[583]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[274]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[584]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[585]

Drug(s) Affected By Guanine nucleotide-binding protein G(i) subunit alpha-2 (GNAI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[161]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[131]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[586]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[304]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]

Drug(s) Affected By Coiled-coil domain-containing protein 159 (CCDC159)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[281]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[229]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[230]

Drug(s) Affected By Ras-related C3 botulinum toxin substrate 2 (RAC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[587]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[278]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[269]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[148]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[517]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[421]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Bortezomib	DMNO38U	Leukemia		Approved	[144]

Drug(s) Affected By Fumarylacetoacetase (FAH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[365]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[284]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[220]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]

Drug(s) Affected By Homeobox protein Hox-B9 (HOXB9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[174]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[268]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[588]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[588]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Dabigatran	DMDI6R4	Stroke	8B20	Approved	[588]
Abacavir	DMMN36E	Human immunodeficiency virus infection	1C62	Approved	[588]

Drug(s) Affected By Keratin, type I cytoskeletal 15 (KRT15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[533]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[290]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[290]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[450]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[202]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[202]

Drug(s) Affected By Small proline-rich protein 2D (SPRR2D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[424]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[335]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[142]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]

Drug(s) Affected By Protein S100-A2 (S100A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[301]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[450]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[155]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[152]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[589]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[295]

Drug(s) Affected By Caspase-14 (CASP14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[450]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[163]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[590]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[295]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[454]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[277]
PHENCYCLIDINE	DMQBEYX	Discovery agent	N.A.	Investigative	[591]

Drug(s) Affected By Long-chain-fatty-acid--CoA ligase 1 (ACSL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[236]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[148]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[592]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[593]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[202]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[202]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[202]

Drug(s) Affected By Interferon alpha-inducible protein 27, mitochondrial (IFI27)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[373]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[373]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[150]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[450]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[173]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[594]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[155]

Drug(s) Affected By Epithelial membrane protein 1 (EMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[177]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[290]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[177]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[290]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[148]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[149]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[150]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[201]

Drug(s) Affected By ATP synthase subunit epsilon, mitochondrial (ATP5F1E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[196]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[595]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[238]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[217]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[141]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[596]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[230]

Drug(s) Affected By 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (HSD17B7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[597]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[298]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[269]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]

Drug(s) Affected By Ribose-phosphate pyrophosphokinase 1 (PRPS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[250]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[202]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[199]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[598]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[335]

Drug(s) Affected By Rho-related GTP-binding protein RhoE (RND3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[270]
Selenium	DM25CGV	N. A.	N. A.	Approved	[161]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[599]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[269]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[148]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[600]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[202]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[202]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[245]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]

Drug(s) Affected By Small ribosomal subunit protein eS24 (RPS24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[159]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[148]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[148]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[262]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[601]

Drug(s) Affected By Keratin, type II cuticular Hb5 (KRT85)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[301]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[282]

Drug(s) Affected By Large neutral amino acids transporter small subunit 1 (SLC7A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[567]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[178]
Selenium	DM25CGV	N. A.	N. A.	Approved	[161]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[579]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[602]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[269]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[148]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[184]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[567]

Drug(s) Affected By Paired box protein Pax-8 (PAX8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[449]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[603]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[604]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[140]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[335]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[325]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[409]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[136]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[605]

Drug(s) Affected By Cytochrome P450 4F3 (CYP4F3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[179]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[278]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[269]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[606]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[155]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[607]

Drug(s) Affected By Melatonin-related receptor (GPR50)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[252]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[313]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[281]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[608]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[609]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[568]

Drug(s) Affected By Endoplasmic reticulum membrane sensor NFE2L1 (NFE2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[178]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[334]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[154]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[242]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[221]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[199]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[610]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[295]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[611]

Drug(s) Affected By Protein Aster-B (GRAMD1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[227]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[295]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[281]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[609]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[461]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[601]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[230]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[191]

Drug(s) Affected By Interferon-induced protein 44-like (IFI44L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[373]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[373]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[371]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[358]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[148]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[155]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]

Drug(s) Affected By SH3 domain-containing protein 19 (SH3D19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[236]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[612]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[410]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[304]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]

Drug(s) Affected By Late cornified envelope protein 1B (LCE1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[613]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[155]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[277]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[155]

Drug(s) Affected By Keratin, type II cytoskeletal 80 (KRT80)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[177]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[177]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[371]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[201]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[201]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[245]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[152]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[220]

Drug(s) Affected By TMF-regulated nuclear protein 1 (TRNP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[554]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[148]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[130]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[263]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[152]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[158]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[159]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[614]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[615]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[148]

Drug(s) Affected By Solute carrier family 25 member 48 (SLC25A48)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[616]
Maleic Acid	DM4L0R7	Discovery agent	N.A.	Investigative	[617]

Drug(s) Affected By Activity-regulated cytoskeleton-associated protein (ARC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[156]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[281]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[136]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[461]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[618]

Drug(s) Affected By 5'-deoxynucleotidase HDDC2 (HDDC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[201]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[201]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[158]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[141]

Drug(s) Affected By Low-density lipoprotein receptor class A domain-containing protein 3 (LDLRAD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[149]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[220]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[168]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[217]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[619]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[230]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[148]

Drug(s) Affected By Neuronal PAS domain-containing protein 3 (NPAS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[236]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[272]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[327]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[620]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[236]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[327]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[333]

Drug(s) Affected By Prominin-2 (PROM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[150]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[450]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[158]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[465]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[230]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[621]

Drug(s) Affected By Synaptopodin (SYNPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[161]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[149]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[245]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[227]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[158]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[141]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[622]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[161]

Drug(s) Affected By Cilia- and flagella-associated protein 43 (CFAP43)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[136]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[623]

Drug(s) Affected By Protein FAM83F (FAM83F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[229]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[277]

Drug(s) Affected By Interferon-induced protein 44 (IFI44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[373]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[516]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[373]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[371]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[463]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[594]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[155]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[373]
Bortezomib	DMNO38U	Leukemia		Approved	[144]

Drug(s) Affected By Retinoic acid early transcript 1E (RAET1E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[220]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[609]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[568]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[277]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[624]

Drug(s) Affected By Glucose-6-phosphate exchanger SLC37A2 (SLC37A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[602]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[154]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[615]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[625]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[136]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[277]

Drug(s) Affected By Prospero homeobox protein 1 (PROX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[213]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[149]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[156]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[626]

Drug(s) Affected By Phosphatidate cytidylyltransferase 1 (CDS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[161]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[174]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[627]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[252]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[245]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[327]

Drug(s) Affected By Solute carrier organic anion transporter family member 2A1 (SLCO2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[628]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[602]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[629]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[365]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[152]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[630]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[460]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[631]

Drug(s) Affected By SH3 domain-containing kinase-binding protein 1 (SH3KBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[191]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[148]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[371]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[252]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[263]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[205]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[158]

Drug(s) Affected By Androgen-dependent TFPI-regulating protein (ADTRP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[269]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[371]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[245]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[393]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[624]

Drug(s) Affected By Gasdermin-A (GSDMA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[335]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[229]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[601]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[277]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[632]

Drug(s) Affected By SH3 and cysteine-rich domain-containing protein (STAC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[450]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[320]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[295]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[141]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[154]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]

Drug(s) Affected By Cell growth regulator with EF hand domain protein 1 (CGREF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[313]
Bortezomib	DMNO38U	Leukemia		Approved	[422]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[141]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[136]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[141]

Drug(s) Affected By Melanophilin (MLPH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[245]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[612]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[633]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[634]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[217]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[615]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]

Drug(s) Affected By Protein Niban 1 (NIBAN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[161]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[635]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[371]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[252]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[226]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[263]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[258]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[152]

Drug(s) Affected By Tubulointerstitial nephritis antigen-like (TINAGL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[218]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[252]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[281]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[229]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[230]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[236]

Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 19 (ADAM19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[150]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[252]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[245]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[152]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[317]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[280]

Drug(s) Affected By Transmembrane protein 222 (TMEM222)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[161]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[304]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[280]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[280]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[161]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[191]

Drug(s) Affected By Beta-defensin 129 (DEFB129)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[636]

Drug(s) Affected By CXADR-like membrane protein (CLMP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[371]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[263]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[281]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[609]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[236]

Drug(s) Affected By Protein S100-A14 (S100A14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[554]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[152]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[637]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[276]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[578]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]

Drug(s) Affected By SH2 domain-containing protein 2A (SH2D2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[149]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[131]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[281]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[154]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[393]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[581]
PHENCYCLIDINE	DMQBEYX	Discovery agent	N.A.	Investigative	[638]

Drug(s) Affected By Triggering receptor expressed on myeloid cells 1 (TREM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[450]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[463]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[639]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[640]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[641]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[239]
Nickel chloride	DMI12Y8	Discovery agent	N.A.	Investigative	[641]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[632]

Drug(s) Affected By Serine palmitoyltransferase 3 (SPTLC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[152]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[457]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[159]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]

Drug(s) Affected By G patch domain-containing protein 2 (GPATCH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[155]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[335]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[141]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[136]

Drug(s) Affected By DNA damage-inducible transcript 4 protein (DDIT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[270]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[231]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[490]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[642]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[643]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[370]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[644]

Drug(s) Affected By Protocadherin Fat 2 (FAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[645]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[136]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[620]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[277]

Drug(s) Affected By Myoferlin (MYOF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[148]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[517]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[646]

Drug(s) Affected By Coiled-coil domain-containing protein 167 (CCDC167)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[280]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[168]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[286]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[393]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[327]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[277]

Drug(s) Affected By Cysteine-rich C-terminal protein 1 (CRCT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[123]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[371]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[245]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[227]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[220]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[647]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[277]

Drug(s) Affected By STEAP1 protein (STEAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[263]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[152]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[219]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[159]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[648]

Drug(s) Affected By Protein mono-ADP-ribosyltransferase PARP4 (PARP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[204]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[130]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[159]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[614]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]
Lithium	DMZ3OU6	Bipolar disorder	6A60	Phase 2	[519]

Drug(s) Affected By Hippocalcin-like protein 4 (HPCAL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[174]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[152]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[335]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[649]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[229]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[141]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[236]

Drug(s) Affected By Angiopoietin-4 (ANGPT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[236]

Drug(s) Affected By Hairy/enhancer-of-split related with YRPW motif protein 1 (HEY1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[650]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[289]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[220]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[457]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]

Drug(s) Affected By Adhesion G-protein coupled receptor G1 (ADGRG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[181]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[148]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[450]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[651]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[451]

Drug(s) Affected By Steroidogenic factor 1 (NR5A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[652]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[653]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[654]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[655]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[656]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]
27-hydroxycholesterol	DM2L6OZ	Discovery agent	N.A.	Investigative	[657]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[658]
Forskolin	DM6ITNG	Solid tumour/cancer	2A00-2F9Z	Investigative	[659]

Drug(s) Affected By ETS domain-containing protein Elk-1 (ELK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[660]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[178]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[661]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[662]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[256]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[663]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[144]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]

Drug(s) Affected By RNA binding protein fox-1 homolog 3 (RBFOX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[174]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[536]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[148]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[150]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[664]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[158]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[148]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[148]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]

Drug(s) Affected By Dynamin-1-like protein (DNM1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[665]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[666]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[587]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[131]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[667]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[668]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[238]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[665]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[669]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[670]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[484]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[671]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[672]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[487]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[334]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[673]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[674]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[675]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[676]

Drug(s) Affected By Phospholipid-transporting ATPase ABCA1 (ABCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[677]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[678]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[298]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[123]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[679]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[680]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[681]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[682]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[683]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[160]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[684]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[275]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[684]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[685]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[178]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[686]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[687]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[688]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[689]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[275]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[685]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[690]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[214]
Selenium	DM25CGV	N. A.	N. A.	Approved	[691]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[692]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[693]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[694]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[179]

Drug(s) Affected By Lutropin subunit beta (LHB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[695]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[696]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[697]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[698]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[699]
Alprazolam	DMC7XDN	Anxiety		Approved	[700]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Norethindrone acetate	DMDGCQP	N. A.	N. A.	Approved	[696]
Metoclopramide	DMFA5MY	Nausea	MD90	Approved	[698]
Cetrorelix	DMFD9Q6	Ovarian stimulation	LB45.1	Approved	[701]

Drug(s) Affected By Osteocalcin (BGLAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[702]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[703]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[704]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[705]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[706]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[707]
Falecalcitrol	DMBI9ZJ	Hyperparathyroidism	5A51	Approved	[708]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[709]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[273]

Drug(s) Affected By Interstitial collagenase (MMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[456]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[710]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[711]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[712]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[385]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[713]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[714]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[512]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[715]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[214]

Drug(s) Affected By RAF proto-oncogene serine/threonine-protein kinase (RAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[660]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[716]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[717]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[718]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[391]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[719]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[720]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[721]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[289]

Drug(s) Affected By High affinity nerve growth factor receptor (NTRK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[722]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[149]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[723]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[227]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[724]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[158]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[141]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[154]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[725]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[491]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[726]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[485]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[178]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[693]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[532]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[727]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[728]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[729]

Drug(s) Affected By Neurofilament medium polypeptide (NEFM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[160]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[236]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[449]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[730]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[152]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[219]
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[731]

Drug(s) Affected By Involucrin (IVL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[732]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[522]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[733]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[301]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[613]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[732]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[734]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[155]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[735]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[522]

Drug(s) Affected By Heat shock protein HSP 90-alpha (HSP90AA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[736]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[200]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[480]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[737]
Selenium	DM25CGV	N. A.	N. A.	Approved	[161]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[738]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[739]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[303]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 16 (NGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[424]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[740]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[174]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[741]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[148]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[742]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[742]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[450]
Oxaprozin	DM9UB0P	Osteoarthritis	FA00-FA05	Approved	[743]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]

Drug(s) Affected By Stromelysin-1 (MMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[339]
Fluvastatin	DM4MDJY	Arteriosclerosis	BD40	Approved	[339]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[339]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[339]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[200]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[118]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[712]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[744]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[745]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[512]

Drug(s) Affected By Integrin alpha-IIb (ITGA2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[746]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[177]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[214]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[746]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[747]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[177]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]
Abciximab	DMJO6GV	Acute disease		Approved	[339]
Tirofiban	DMQG17S	Acute coronary syndrome	BA41	Approved	[339]
Eptifibatide	DMQXTJS	Acute cardiac ischemic events	BA40.Z	Approved	[339]

Drug(s) Affected By Proto-oncogene tyrosine-protein kinase Src (SRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosutinib	DMTI8YE	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[748]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[749]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[179]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[750]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[751]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[752]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[518]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[518]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]

Drug(s) Affected By Elongation factor 2 (EEF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[753]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[754]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[367]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[305]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[574]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[755]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[136]

Drug(s) Affected By 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[236]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[269]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[201]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[201]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[756]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[757]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[421]
Hexachlorophene	DMLKSE0	Bacterial infection	1A00-1C4Z	Approved	[758]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[759]

Drug(s) Affected By 17-beta-hydroxysteroid dehydrogenase type 1 (HSD17B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[597]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Metyrapone	DMI7FVQ	Cushing disease	5A70	Approved	[760]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[761]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[759]
Dutasteride	DMQ4TJK	Benign prostatic hyperplasia	GA90	Approved	[762]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[763]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[759]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[597]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[764]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[386]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[275]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[372]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[178]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[765]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[766]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[288]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[767]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[389]

Drug(s) Affected By Endothelial transcription factor GATA-2 (GATA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[181]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[148]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[768]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[769]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[252]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[190]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[522]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[486]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[672]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[770]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[434]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[771]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[772]
Fructose	DM43AN2	Vomiting	MD90	Approved	[436]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[522]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[299]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[773]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[774]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[775]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[776]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[777]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[778]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[779]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[780]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[781]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[782]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[783]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[774]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[784]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[785]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[786]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[773]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[339]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[200]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[776]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[777]

Drug(s) Affected By G1/S-specific cyclin-D2 (CCND2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Selenium	DM25CGV	N. A.	N. A.	Approved	[691]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[385]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[729]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[787]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[788]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[483]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[789]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[245]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]

Drug(s) Affected By Neuronal acetylcholine receptor subunit alpha-3 (CHRNA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[141]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[154]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[148]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[148]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[568]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[230]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[399]

Drug(s) Affected By Reduced folate transporter (SLC19A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[790]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[791]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[791]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Selenium	DM25CGV	N. A.	N. A.	Approved	[161]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[137]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[792]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[792]
Atenolol	DMNKG1Z	Angina pectoris	BA40	Approved	[792]

Drug(s) Affected By Collagenase 3 (MMP13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[793]
Clindamycin	DM15HL8	Acne vulgaris	ED80	Approved	[794]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[793]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[533]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[795]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[796]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[797]
Doxycycline	DM7ICNU	Acne vulgaris	ED80	Approved	[794]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[289]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[798]

Drug(s) Affected By Histone H2B type 1-D (H2BC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[181]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[269]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[799]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[201]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[201]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[273]

Drug(s) Affected By Ubiquitin-ribosomal protein eS31 fusion protein (RPS27A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[387]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[800]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[196]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[205]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[801]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[217]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[141]

Drug(s) Affected By Casein kinase II subunit alpha (CSNK2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[161]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[334]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[802]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[334]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[803]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[804]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]

Drug(s) Affected By Histone H3.1 (H3C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[424]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[599]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[797]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[644]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[201]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[201]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[245]

Drug(s) Affected By Cytochrome c (CYCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[200]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[805]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[806]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[807]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[808]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[809]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[179]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[810]
Pefloxacin	DM49IGF	Gonococcal urethritis	1A70.0Y	Approved	[811]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[200]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[812]
Selenium	DM25CGV	N. A.	N. A.	Approved	[161]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[427]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[767]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[813]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[814]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[815]

Drug(s) Affected By Tight junction protein ZO-1 (TJP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[703]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[178]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[385]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[149]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[154]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[816]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[817]

Drug(s) Affected By Histone RNA hairpin-binding protein (SLBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[236]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[490]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[181]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[490]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[457]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[490]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[490]

Drug(s) Affected By Neuronal acetylcholine receptor subunit alpha-6 (CHRNA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[268]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[601]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[155]

Drug(s) Affected By NACHT, LRR and PYD domains-containing protein 3 (NLRP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[200]
Selenium	DM25CGV	N. A.	N. A.	Approved	[395]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[818]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[819]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[150]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[820]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[821]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[822]
Atropine	DMEN6X7	Organophosphate poisoning	NE6Z	Approved	[823]

Drug(s) Affected By Flavin-containing monooxygenase 3 (FMO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[295]
Perazine	DM2AOTZ	Psychotic disorder	6A20-6A25	Approved	[824]
Almogran	DM7I64Z	Migraine	8A80	Approved	[825]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[826]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[827]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[828]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[829]

Drug(s) Affected By Regulatory-associated protein of mTOR (RPTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[236]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[830]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[138]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[144]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[831]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[127]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[158]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[832]

Drug(s) Affected By LysM and putative peptidoglycan-binding domain-containing protein 3 (LYSMD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[154]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[230]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[191]

Drug(s) Affected By Tyrosine-protein kinase JAK2 (JAK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Momelotinib	DMF98Q0	Myelofibrosis	2A20.2	Approved	[833]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[567]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[231]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[834]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[567]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[627]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[835]

Drug(s) Affected By Pleckstrin homology domain-containing family G member 1 (PLEKHG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[155]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[220]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[135]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[295]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[148]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[190]

Drug(s) Affected By Solute carrier family 22 member 2 (SLC22A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[836]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[837]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[837]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[838]
Lamivudine	DMI347A	Chronic HBV infection	1E51.0Z	Approved	[839]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[838]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[840]
Trospium chloride	DM32XZT	Discovery agent	N.A.	Approved	[841]
Phenoxybenzamine	DM8KSQH	Malignant essential hypertension	BA00	Approved	[842]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[154]

Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[339]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[843]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[844]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[522]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[704]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[642]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[845]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[846]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[847]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[848]

Drug(s) Affected By Plastin-2 (LCP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[849]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[619]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[152]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[153]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[158]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[145]

Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PIK3CB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[160]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[236]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[142]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[850]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[134]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[146]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[142]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[851]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Nicotinic acetylcholine receptor (nAChR)	TTJSZTB	NOUNIPROTAC	Antagonist	[4]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[5]
Cytochrome P450 2E1 (CYP2E1)	DEVDYN7	CP2E1_HUMAN	Substrate	[6]
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Substrate	[5]
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Substrate	[5]
Cytochrome P450 1A1 (CYP1A1)	DE6OQ3W	CP1A1_HUMAN	Substrate	[5]
UDP-glucuronosyltransferase 1A1 (UGT1A1)	DEYGVN4	UD11_HUMAN	Substrate	[7]
Mephenytoin 4-hydroxylase (CYP2C19)	DEGTFWK	CP2CJ_HUMAN	Substrate	[5]
Cytochrome P450 2A6 (CYP2A6)	DEJVYAZ	CP2A6_HUMAN	Substrate	[8]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Substrate	[5]
Cytochrome P450 2B6 (CYP2B6)	DEPKLMQ	CP2B6_HUMAN	Substrate	[9]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Substrate	[5]
Cytochrome P450 2A13 (CYP2A13)	DEXZA9U	CP2AD_HUMAN	Substrate	[10]
Nicotinate dehydrogenase (nicA)	DE4AMLP	NICA_PSEPK	Substrate	[11]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
17-beta-hydroxysteroid dehydrogenase type 1 (HSD17B1)	OT6EBDHM	DHB1_HUMAN	Gene/Protein Processing	[12]
2'-5'-oligoadenylate synthase 1 (OAS1)	OT8ZLOCY	OAS1_HUMAN	Gene/Protein Processing	[13]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1)	OTNAZVKB	3BHS1_HUMAN	Gene/Protein Processing	[12]
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (HSD17B7)	OTV7VOV3	DHB7_HUMAN	Gene/Protein Processing	[13]
5'-deoxynucleotidase HDDC2 (HDDC2)	OTSO0JP4	HDDC2_HUMAN	Gene/Protein Processing	[13]
Activity-regulated cytoskeleton-associated protein (ARC)	OTN2QQPG	ARC_HUMAN	Gene/Protein Processing	[13]
Adhesion G-protein coupled receptor G1 (ADGRG1)	OTQBB8NT	AGRG1_HUMAN	Gene/Protein Processing	[13]
Alpha-synuclein (SNCA)	OTPWC1MR	SYUA_HUMAN	Gene/Protein Processing	[14]
Amyloid-beta precursor protein (APP)	OTKFD7R4	A4_HUMAN	Gene/Protein Processing	[15]
Androgen-dependent TFPI-regulating protein (ADTRP)	OTFI2BQX	ADTRP_HUMAN	Gene/Protein Processing	[13]

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