Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWX5CO)

• Drug Name: Nicotine Drug Info
• Synonyms: Habitrol; Micotine; NCT; NICOTINE AND SALTS; Nicoderm Patch; Nicotina [Italian]; Nicotine Patch; Nicotine [USAN]; Nicotine replacement patch; Nicotine solution; Nictoine patch; Nikotin [German]; Nikotyna [Polish]; Transdermal Nicotine; Nicotine [UN1654] [Poison]; ENT 3,424; Habitrol (TN); Nicorette (TN); Nicotine (USP); Nicotine (compounds related to); Nicotine [BSI:ISO]; L(-)-nicotine; Beta-Pyridyl-alpha-N-methyl pyrrolidine; (-)-Nicotine solution; (2S) 3-(1-Methyl-pyrrolidin-2-yl)-pyridine; (S)-(-)-NICOTINE, 3-[(2S)-1-METHYL-2-PYRROLIDINYL] PYRIDINE; (S)-(-)-Nicotine; (S)-3-(1-methylpyrrolidin-2-yl)pyridine; (S)-3-(N-methylpyrrolidin-2-yl)pyridine; (S)-Nicotine; 3-(2-(N-methylpyrrolidinyl))pyridine; 3-(N-Methylpyrollidino)pyridine; 3-(N-Methylpyrrolidino)pyridine; 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine

Indication

Disease Entry	ICD 11	Status	REF
Lung cancer	2C25.0	Approved	[1]
Nicotine dependence	6C4A.2	Approved	[2]
Pellagra		Approved	[1]
Tobacco dependence	6C4A.2	Clinical trial	[3]

• Cross-matching ID:
  PubChem CID: 89594
  ChEBI ID: CHEBI:17688
  CAS Number: CAS 54-11-5
  TTD Drug ID: DMWX5CO
  VARIDT Drug ID: DR00679
  INTEDE Drug ID: DR1148

Molecule-Related Drug Atlas

Drug(s) Targeting Nicotinic acetylcholine receptor (nAChR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cotinine	DMCEZ1B	Insecticide	N.A.	Approved	[18]
Pancuronium	DMB0VY8	Anaesthesia	9A78.6	Approved	[19]
Atracurium	DM42HXN	Anaesthesia	9A78.6	Approved	[19]
Mecamylamine	DMGQFYB	Essential hypertension	BA00	Approved	[20]
CYTISINE	DMUF0BJ	Tobacco dependence	6C4A.2	Phase 3	[3]
Dexefaroxan	DMTY4KN	Parkinson disease	8A00.0	Phase 2	[21]
BMS-954561	DM7XV4R	Diabetic neuropathy	8C0Z	Phase 2	[22]
ASM-024	DM35S2I	Asthma	CA23	Phase 2	[23]
NIC-002	DMKLJMI	Nicotine dependence	6C4A.2	Phase 2	[24]
TRIDMAC	DMWU41P	Mood disorder	6A60-6E23	Phase 2	[25]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[27]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[28]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[29]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[30]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[31]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[32]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[33]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[27]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[34]

Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[35]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[36]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[37]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[38]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[39]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[32]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[41]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[42]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[43]
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[110]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[110]
Etoricoxib	DM6A4NW	Rheumatoid arthritis	FA20	Approved	[110]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[111]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[112]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[113]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[114]
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[115]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[116]
Caffeine	DMKBJWP	Allergic rhinitis	CA08.0	Approved	[117]

Drug(s) Metabolized By UDP-glucuronosyltransferase 1A1 (UGT1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[44]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[45]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[46]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[47]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[49]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[50]
Metronidazole	DMTIVEN	Abscess		Approved	[51]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[52]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[53]

Drug(s) Metabolized By Cytochrome P450 2A6 (CYP2A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[35]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[54]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[55]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[30]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[56]
Metronidazole	DMTIVEN	Abscess		Approved	[57]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[54]
Tegafur	DM31ZQM	Solid tumour/cancer	2A00-2F9Z	Approved	[128]
Methoxsalen	DME8FZ9	Cutaneous T-cell lymphoma	2B01	Approved	[129]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[131]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[29]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[133]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[134]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[135]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[136]

Drug(s) Metabolized By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[59]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[60]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[62]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[41]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[63]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[64]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[65]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[66]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[67]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[118]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[119]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[120]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[121]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[122]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[123]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[124]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[125]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[126]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[127]

Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[68]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[69]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[70]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[30]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[34]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[71]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[72]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[73]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[74]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[75]

Drug(s) Metabolized By Cytochrome P450 2E1 (CYP2E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[76]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[77]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[55]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[78]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[79]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[41]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[54]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[80]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[81]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[82]

Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[35]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[83]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[54]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[84]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[85]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[86]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[83]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[87]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[58]

Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[88]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[89]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[90]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[54]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[91]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[54]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[92]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[93]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]

Drug(s) Metabolized By Cytochrome P450 2B6 (CYP2B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[96]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[54]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[97]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[99]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[100]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[101]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]

Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[103]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[88]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[104]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[105]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[54]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[106]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[63]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[107]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[58]

Drug(s) Metabolized By Cytochrome P450 2A13 (CYP2A13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone cypionate	DMC1TEV	N. A.	N. A.	Approved	[108]
Phenacetin	DMRQAM0	Analgesia	MB40.8	Withdrawn from market	[109]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[137]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[138]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[139]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[140]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[142]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[144]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[145]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[146]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[147]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[148]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[149]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[150]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[151]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[152]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[153]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[154]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[152]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[155]

Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[157]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[158]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[159]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[145]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[161]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[163]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[160]

Drug(s) Affected By Delta-aminolevulinic acid dehydratase (ALAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[164]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[167]
Mestranol	DMG3F94	Contraception	QA21	Approved	[164]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[164]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[168]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[170]

Drug(s) Affected By Tissue-type plasminogen activator (PLAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[172]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[173]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[174]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[175]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[176]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[178]
Fructose	DM43AN2	Vomiting	MD90	Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]

Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[181]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[172]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[182]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[183]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[184]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[185]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[186]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[187]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[188]

Drug(s) Affected By Angiotensin-converting enzyme (ACE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trandolapril	DM4L6EU	Chronic heart failure	BD1Z	Approved	[116]
Fosinopril	DM9NJ52	Chronic heart failure	BD1Z	Approved	[116]
Quinapril	DMR8H31	Chronic heart failure	BD1Z	Approved	[116]
Cilazapril	DM4V6JA	Congestive heart failure	BD10	Approved	[189]
Perindopril	DMOPZDT	Hypertension	BA00-BA04	Approved	[190]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[191]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[192]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[194]
Cenestin	DMXQS7K	Menopause symptom	GA30.0	Approved	[195]

Drug(s) Affected By Nitric oxide synthase 3 (NOS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[196]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[197]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[116]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[198]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[199]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[200]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[201]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[202]
Fructose	DM43AN2	Vomiting	MD90	Approved	[203]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[204]

Drug(s) Affected By Regulatory factor X-associated protein (RFXAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[210]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[212]

Drug(s) Affected By Dihydrofolate reductase (DHFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[213]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[214]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[215]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[216]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[217]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[218]
Ceftriaxone	DMCEW64	Acute gonococcal cervicitis		Approved	[215]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[219]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase alpha (PTPRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Mecamylamine	DMGQFYB	Essential hypertension	BA00	Approved	[218]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[205]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[222]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[223]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[212]

Drug(s) Affected By Ras-related protein Rab-6A (RAB6A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Risedronate	DM5FLTY	Bone Paget disease		Approved	[225]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[226]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[223]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[224]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[229]

Drug(s) Affected By Tissue factor pathway inhibitor 2 (TFPI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[230]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[231]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[192]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[232]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]

Drug(s) Affected By Contactin-1 (CNTN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[230]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[234]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Mecamylamine	DMGQFYB	Essential hypertension	BA00	Approved	[218]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[235]

Drug(s) Affected By Rho guanine nucleotide exchange factor 7 (ARHGEF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[219]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[237]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[238]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[205]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[239]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[240]

Drug(s) Affected By E3 ubiquitin-protein ligase RBBP6 (RBBP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[241]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[242]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[243]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]

Drug(s) Affected By Histone-lysine N-methyltransferase 2C (KMT2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[244]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[245]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[218]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[246]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[247]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[248]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]

Drug(s) Affected By Fasciculation and elongation protein zeta-1 (FEZ1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[249]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[250]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[230]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[252]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[218]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[219]
Mecamylamine	DMGQFYB	Essential hypertension	BA00	Approved	[218]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[232]

Drug(s) Affected By Lipopolysaccharide-induced tumor necrosis factor-alpha factor (LITAF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[199]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[192]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[243]
Mecamylamine	DMGQFYB	Essential hypertension	BA00	Approved	[218]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[232]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]

Drug(s) Affected By Echinoderm microtubule-associated protein-like 4 (EML4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[249]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[253]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[254]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Mecamylamine	DMGQFYB	Essential hypertension	BA00	Approved	[218]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[210]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[226]

Drug(s) Affected By Copper chaperone for superoxide dismutase (CCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[185]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[252]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[255]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[256]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[257]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[258]
Haloperidol	DM96SE0	Delirium		Approved	[116]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[259]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[260]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[153]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[261]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[262]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[263]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[264]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[265]

Drug(s) Affected By Amyloid-beta precursor protein (APP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[266]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[267]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[268]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[269]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[270]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[271]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[272]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[273]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[274]

Drug(s) Affected By Syntaxin-binding protein 3 (STXBP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[275]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[219]
SEROTONIN	DMOFCRY	Discovery agent	N.A.	Investigative	[276]

Drug(s) Affected By Chloride intracellular channel protein 1 (CLIC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[277]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[278]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[279]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[280]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[239]

Drug(s) Affected By Segment polarity protein dishevelled homolog DVL-2 (DVL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[281]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[283]
Calphostin C	DM9X2D0	N. A.	N. A.	Terminated	[284]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[285]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[286]

Drug(s) Affected By Chromodomain-helicase-DNA-binding protein 2 (CHD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[287]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[288]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Bortezomib	DMNO38U	Leukemia		Approved	[226]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[289]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[223]

Drug(s) Affected By UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[290]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Bortezomib	DMNO38U	Leukemia		Approved	[226]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[205]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[291]

Drug(s) Affected By Apoptosis regulatory protein Siva (SIVA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[292]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[293]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[293]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[294]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[294]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[294]
Bortezomib	DMNO38U	Leukemia		Approved	[295]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]

Drug(s) Affected By Cytoplasmic dynein 1 light intermediate chain 2 (DYNC1LI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[199]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[283]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[296]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[297]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[205]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[224]

Drug(s) Affected By E3 ubiquitin-protein ligase parkin (PRKN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Emtricitabine	DMBMUWZ	Hepatitis virus infection	1E50-1E51	Approved	[298]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[299]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[300]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[301]
Methamphetamine	DMPM4SK	Anxiety		Approved	[302]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[303]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[239]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]

Drug(s) Affected By C-Jun-amino-terminal kinase-interacting protein 4 (SPAG9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[245]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[252]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[240]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[223]

Drug(s) Affected By Stanniocalcin-2 (STC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[304]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[305]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[269]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[234]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[15]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[306]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[307]

Drug(s) Affected By Transferrin receptor protein 1 (TFRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[260]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[308]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[309]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[310]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[311]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[312]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[216]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[313]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[314]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[315]

Drug(s) Affected By Glutathione peroxidase 1 (GPX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[316]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Amlexanox	DM0DQM5	Respiratory tract inflammation	CA07	Approved	[317]
Selenium	DM25CGV	N. A.	N. A.	Approved	[318]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[319]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[320]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[321]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[322]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[323]

Drug(s) Affected By Serine protease 1 (PRSS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[324]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[325]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[326]
Coprexa	DMA0WEK	Neurological disorder	6B60	Phase 3	[327]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[328]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]

Drug(s) Affected By Laminin subunit beta-1 (LAMB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[249]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[329]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[232]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[330]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[331]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[280]

Drug(s) Affected By Myb-related protein B (MYBL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[266]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[332]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[333]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[334]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[231]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[293]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[333]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[335]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[336]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]

Drug(s) Affected By Complement component C7 (C7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[249]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[17]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[337]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[338]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[240]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[235]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[339]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[275]

Drug(s) Affected By Nucleoprotein TPR (TPR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[340]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[283]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[245]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[252]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[297]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[297]

Drug(s) Affected By Acylamino-acid-releasing enzyme (APEH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[240]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[236]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[341]

Drug(s) Affected By Glucosidase 2 subunit beta (PRKCSH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[342]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[343]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[344]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[229]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[229]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[345]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[275]

Drug(s) Affected By Membrane cofactor protein (CD46)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[292]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
ABIRATERONE	DM8V75C	Prostate cancer	2C82.0	Approved	[346]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[346]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]

Drug(s) Affected By High mobility group protein HMG-I/HMG-Y (HMGA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[266]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[347]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[348]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Methamphetamine	DMPM4SK	Anxiety		Approved	[349]

Drug(s) Affected By Creatine kinase S-type, mitochondrial (CKMT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[350]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[351]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[352]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[353]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[339]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[350]

Drug(s) Affected By S-adenosylmethionine decarboxylase proenzyme (AMD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[231]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[354]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Indomethacin	DMSC4A7	Bursitis		Approved	[355]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[240]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[356]

Drug(s) Affected By Interferon-induced, double-stranded RNA-activated protein kinase (EIF2AK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[357]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[358]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[252]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[359]

Drug(s) Affected By Thymidylate kinase (DTYMK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[269]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[293]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[293]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[230]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[238]

Drug(s) Affected By Calreticulin (CALR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[249]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[360]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[273]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[361]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[362]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[363]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[364]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[297]

Drug(s) Affected By Cellular retinoic acid-binding protein 2 (CRABP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[257]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[365]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[257]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[366]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[230]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[231]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[354]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[367]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]

Drug(s) Affected By GTP cyclohydrolase 1 (GCH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[368]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[369]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[192]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[368]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[370]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[368]

Drug(s) Affected By Stress-induced-phosphoprotein 1 (STIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[371]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[372]
Haloperidol	DM96SE0	Delirium		Approved	[297]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[297]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[297]
Mecamylamine	DMGQFYB	Essential hypertension	BA00	Approved	[17]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[373]

Drug(s) Affected By Cyclin-dependent kinases regulatory subunit 2 (CKS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[269]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[334]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[217]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[293]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[293]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[252]

Drug(s) Affected By Transgelin-2 (TAGLN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[297]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[230]
Haloperidol	DM96SE0	Delirium		Approved	[297]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[278]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[297]

Drug(s) Affected By Patatin-like phospholipase domain-containing protein 4 (PNPLA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[267]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[192]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[223]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[143]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[350]

Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[292]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[273]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[374]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[375]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[376]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[377]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[378]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[379]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[380]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[381]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[382]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[383]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[384]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[385]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[386]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[387]

Drug(s) Affected By Transcriptional regulator ATRX (ATRX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[388]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[252]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[389]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[390]

Drug(s) Affected By Translation initiation factor IF-2, mitochondrial (MTIF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[239]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[240]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[391]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[391]
Josamycin	DMKJ8LB	Bacterial infection	1A00-1C4Z	Approved	[391]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[392]

Drug(s) Affected By F-actin-capping protein subunit alpha-2 (CAPZA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[273]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[288]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[291]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[393]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[394]

Drug(s) Affected By Glioma pathogenesis-related protein 1 (GLIPR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[395]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[362]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[219]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[226]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[396]

Drug(s) Affected By Deoxyhypusine synthase (DHPS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[397]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[236]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[143]

Drug(s) Affected By RNA-binding protein 25 (RBM25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[245]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[252]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[219]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[291]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[223]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[223]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[143]

Drug(s) Affected By DNA ligase 4 (LIG4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[217]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[389]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[398]
Bortezomib	DMNO38U	Leukemia		Approved	[226]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[399]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[212]
Fenfluramine	DM0762O	Dravet syndrome	8A61.11	Phase 3	[400]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]

Drug(s) Affected By Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10 (GNG10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[292]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[401]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[339]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[230]

Drug(s) Affected By Serpin H1 (SERPINH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[267]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[402]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[403]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[226]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[247]

Drug(s) Affected By H(+)/Cl(-) exchange transporter 3 (CLCN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[216]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[252]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]

Drug(s) Affected By Protein FosB (FOSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[306]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[216]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[288]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[404]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[231]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[311]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[405]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[406]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[407]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[408]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[304]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[409]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[410]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[411]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[412]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[413]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[414]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[415]

Drug(s) Affected By Protein transport protein Sec61 subunit gamma (SEC61G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[416]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[231]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[205]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[328]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[417]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[212]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[286]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[418]

Drug(s) Affected By Myosin light polypeptide 6 (MYL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[321]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[247]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[205]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[328]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[417]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[419]

Drug(s) Affected By CMP-sialic acid transporter (SLC35A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[170]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[170]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[420]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[421]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[418]

Drug(s) Affected By Cyclin-dependent kinase 6 (CDK6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[422]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[423]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[424]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[425]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[199]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[426]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[427]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[269]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[230]

Drug(s) Affected By Centromere-associated protein E (CENPE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[340]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[269]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[293]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[293]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[428]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[330]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha (PPP2R3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[375]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[429]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[239]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[417]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[430]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[431]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[143]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]

Drug(s) Affected By Phosphatidylinositol-glycan biosynthesis class F protein (PIGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[223]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[432]

Drug(s) Affected By Son of sevenless homolog 1 (SOS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[433]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[231]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[434]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[252]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]

Drug(s) Affected By Zinc finger protein Rlf (RLF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[294]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[294]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[294]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[240]

Drug(s) Affected By Chromobox protein homolog 3 (CBX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[249]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[180]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[219]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[180]
Bortezomib	DMNO38U	Leukemia		Approved	[226]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]

Drug(s) Affected By Origin recognition complex subunit 2 (ORC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[401]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[435]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[224]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[339]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[283]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[219]

Drug(s) Affected By Zinc transporter ZIP6 (SLC39A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[436]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[230]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[437]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[364]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[436]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]

Drug(s) Affected By Golgin subfamily A member 4 (GOLGA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[252]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[17]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[389]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Mecamylamine	DMGQFYB	Essential hypertension	BA00	Approved	[17]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[438]

Drug(s) Affected By Serine incorporator 3 (SERINC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[212]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[143]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[283]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[219]

Drug(s) Affected By Transformer-2 protein homolog alpha (TRA2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[297]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[325]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[245]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[192]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[252]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]

Drug(s) Affected By Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[439]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[440]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[185]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[441]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[216]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]

Drug(s) Affected By Cyclin-dependent kinase 13 (CDK13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[283]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[243]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[442]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[443]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[212]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[143]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[283]

Drug(s) Affected By UDP-glucose 4-epimerase (GALE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[444]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[134]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[212]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]

Drug(s) Affected By Protocadherin Fat 1 (FAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[310]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[445]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[240]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[446]

Drug(s) Affected By Serum paraoxonase/arylesterase 2 (PON2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[447]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[448]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[210]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]

Drug(s) Affected By Thyroid receptor-interacting protein 11 (TRIP11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[389]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[240]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[283]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[418]

Drug(s) Affected By Serine/threonine-protein kinase N2 (PKN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[283]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[245]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[337]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Ximelegatran	DMU8ANS	Myocardial infarction	BA41-BA43	Approved	[449]

Drug(s) Affected By DNA damage-binding protein 1 (DDB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[254]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[450]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[125]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[396]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[451]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[240]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[236]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[452]

Drug(s) Affected By NADH dehydrogenase 1 alpha subcomplex subunit 5 (NDUFA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[291]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Fenretinide	DMRD5SP	Macular degeneration	9B78.3	Phase 3	[453]
biochanin A	DM0HPWY	Discovery agent	N.A.	Investigative	[454]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[455]

Drug(s) Affected By Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[350]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[283]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[456]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[217]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[219]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]

Drug(s) Affected By Transmembrane protein 41B (TMEM41B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[216]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Bortezomib	DMNO38U	Leukemia		Approved	[226]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[442]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[236]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]

Drug(s) Affected By Heterochromatin protein 1-binding protein 3 (HP1BP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[278]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[457]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[226]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[239]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[458]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[394]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]

Drug(s) Affected By Pre-mRNA-splicing factor 38B (PRPF38B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[283]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[286]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[418]

Drug(s) Affected By Lysine-specific demethylase 7A (KDM7A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[304]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[459]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[369]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[234]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[460]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[240]

Drug(s) Affected By Serine/threonine-protein kinase TAO1 (TAOK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[245]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[294]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[294]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[294]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[328]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[223]

Drug(s) Affected By Ninein (NIN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[461]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[294]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[294]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[294]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[294]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[294]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]

Drug(s) Affected By Tribbles homolog 2 (TRIB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[462]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[273]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[429]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[463]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[240]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[464]

Drug(s) Affected By DNA topoisomerase 2-binding protein 1 (TOPBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[269]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[293]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[293]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[219]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[291]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[240]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[465]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[236]

Drug(s) Affected By PHD finger protein 3 (PHF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[283]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[252]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[389]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[466]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[417]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[143]

Drug(s) Affected By Probable ATP-dependent RNA helicase DDX17 (DDX17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[249]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[467]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[468]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[294]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[294]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[252]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]

Drug(s) Affected By DNA repair protein RAD50 (RAD50)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[469]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[188]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[252]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[389]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]

Drug(s) Affected By snRNA-activating protein complex subunit 3 (SNAPC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[470]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[471]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[230]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[339]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[472]

Drug(s) Affected By PHD finger protein 21A (PHF21A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[273]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[231]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[351]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[466]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[420]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[223]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[212]

Drug(s) Affected By THO complex subunit 1 (THOC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[293]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[293]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[473]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[474]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[394]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[283]

Drug(s) Affected By Chloride channel CLIC-like protein 1 (CLCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[475]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[143]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[283]

Drug(s) Affected By Protein SCAF11 (SCAF11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[283]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[245]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[354]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[252]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[389]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[219]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[240]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[476]

Drug(s) Affected By Mediator of RNA polymerase II transcription subunit 28 (MED28)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[249]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[199]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[240]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[339]
Forskolin	DM6ITNG	Solid tumour/cancer	2A00-2F9Z	Investigative	[477]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[478]
[3H]methyltrienolone	DMTSGOW	Discovery agent	N.A.	Investigative	[477]

Drug(s) Affected By Pantothenate kinase 3 (PANK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[440]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[216]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[192]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[479]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[212]

Drug(s) Affected By Arginine and glutamate-rich protein 1 (ARGLU1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[241]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[305]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[199]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[219]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[396]

Drug(s) Affected By DDB1- and CUL4-associated factor 16 (DCAF16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[480]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[339]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[481]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[230]

Drug(s) Affected By Polypyrimidine tract-binding protein 2 (PTBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[185]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[192]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[354]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[429]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[396]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]

Drug(s) Affected By Splicing factor 3B subunit 6 (SF3B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[230]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[394]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[339]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[286]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[418]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[219]

Drug(s) Affected By Protein PRRC2C (PRRC2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[350]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[283]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[468]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[252]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[482]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[483]
Fructose	DM43AN2	Vomiting	MD90	Approved	[116]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[484]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[150]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[416]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[260]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[485]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[486]

Drug(s) Affected By Protein kinase C beta type (PRKCB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[487]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[469]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[230]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[488]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[489]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[487]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[490]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[491]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[492]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[493]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[494]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[495]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[496]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[497]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[152]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[498]

Drug(s) Affected By Beta-2 adrenergic receptor (ADRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salmeterol	DMIEU69	Allergic asthma	CA23.0	Approved	[499]
Bambuterol	DMKLSHF	Asthma	CA23	Approved	[500]
Terbutaline	DMD4381	Asthma	CA23	Approved	[501]
Salbutamol	DMN9CWF	Acute asthma	CA23	Approved	[502]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[503]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[199]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[504]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[505]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[506]

Drug(s) Affected By Beta-1 adrenergic receptor (ADRB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dobutamine	DMD1B8Z	Heart failure	BD10-BD13	Approved	[507]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[508]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[199]
Vortioxetine	DM6F1PU	Major depressive disorder	6A70.3	Approved	[509]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[219]
Labetalol	DMK8U72	Hypertension	BA00-BA04	Approved	[510]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[511]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[512]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]

Drug(s) Affected By Deoxyribonuclease-2-alpha (DNASE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[362]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[243]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[170]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[247]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[239]

Drug(s) Affected By NF-kappa-B inhibitor epsilon (NFKBIE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[513]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[514]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[167]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Bortezomib	DMNO38U	Leukemia		Approved	[515]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[516]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[205]

Drug(s) Affected By Serine/threonine-protein kinase 25 (STK25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[371]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[350]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[517]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[339]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[350]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[518]

Drug(s) Affected By Krueppel-like factor 11 (KLF11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[325]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[231]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[192]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[375]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[519]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[226]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]

Drug(s) Affected By Phospholipase D2 (PLD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[293]
Fentanyl	DM8WAHT	Analgesia	MB40.8	Approved	[520]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[293]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Methadone	DMTW6IU	Advanced cancer	2A00-2F9Z	Approved	[520]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[517]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[339]

Drug(s) Affected By Mothers against decapentaplegic homolog 9 (SMAD9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[396]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[521]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[480]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[522]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[235]

Drug(s) Affected By C-C motif chemokine 16 (CCL16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[476]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[517]

Drug(s) Affected By Death effector domain-containing protein (DEDD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[523]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[524]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[237]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[463]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[143]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[525]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[517]

Drug(s) Affected By DNA fragmentation factor subunit beta (DFFB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[526]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[313]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[188]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[527]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[293]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[293]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]

Drug(s) Affected By Erythropoietin (EPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[528]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[529]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[530]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[531]
Fenoterol	DMIP3ZV	Asthma	CA23	Approved	[532]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[533]
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[534]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[535]

Drug(s) Affected By T-cell surface glycoprotein CD4 (CD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[536]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[354]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[537]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[538]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[479]
Rimexolone	DMTAREC	Arthritis	FA20	Approved	[537]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[539]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[538]

Drug(s) Affected By Fibronectin (FN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[540]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[267]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[541]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[250]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[542]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[543]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[216]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[544]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[545]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[546]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[547]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[267]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[548]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[549]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[381]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[550]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[551]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[138]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[552]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[423]

Drug(s) Affected By Interferon alpha-inducible protein 6 (IFI6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[292]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[512]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[553]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[340]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[554]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[555]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[554]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[527]

Drug(s) Affected By C-C motif chemokine 5 (CCL5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[260]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[556]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[557]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[267]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[558]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[269]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[559]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[560]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[561]

Drug(s) Affected By Retinoic acid receptor gamma (RARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[562]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[563]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[390]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[429]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[564]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[480]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[420]
Fenretinide	DMRD5SP	Macular degeneration	9B78.3	Phase 3	[565]

Drug(s) Affected By CD59 glycoprotein (CD59)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[292]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[566]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[567]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[293]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[293]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]

Drug(s) Affected By POU domain, class 2, transcription factor 1 (POU2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[568]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[273]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[569]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[238]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[568]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[238]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[517]

Drug(s) Affected By Interleukin-9 (IL9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[570]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[571]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[517]
4-hydroxy-2-nonenal	DM2LJFZ	Discovery agent	N.A.	Investigative	[266]

Drug(s) Affected By Ezrin (EZR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[297]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[175]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[230]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[244]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[572]
Haloperidol	DM96SE0	Delirium		Approved	[297]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]

Drug(s) Affected By Cyclic AMP-responsive element-binding protein 1 (CREB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[573]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[574]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[575]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[542]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[576]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[576]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[577]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[578]

Drug(s) Affected By Thyrotropin receptor (TSHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[579]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[580]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[581]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[581]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[582]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[580]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[583]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[458]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]

Drug(s) Affected By Interferon alpha/beta receptor 1 (IFNAR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Amantadine	DMS3YE9	Influenza A virus infection	1E30	Approved	[584]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[240]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[585]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[586]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[517]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[116]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[587]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[199]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[426]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[588]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[313]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[273]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[589]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[590]

Drug(s) Affected By C-X-C motif chemokine 2 (CXCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[304]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Selenium	DM25CGV	N. A.	N. A.	Approved	[591]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[199]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[269]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[554]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[395]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[592]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[354]

Drug(s) Affected By Transcription factor BTF3 (BTF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[273]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[224]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[539]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[517]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[339]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[283]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[455]

Drug(s) Affected By Integrin alpha-L (ITGAL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[266]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[267]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[593]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[594]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[595]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[192]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[594]
Bortezomib	DMNO38U	Leukemia		Approved	[226]

Drug(s) Affected By C5a anaphylatoxin chemotactic receptor 1 (C5AR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[267]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[212]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[596]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[597]
RESORCINOL	DMM37C0	Discovery agent	N.A.	Investigative	[598]

Drug(s) Affected By Interleukin-10 (IL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[599]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[557]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[600]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[601]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[602]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[603]
Bisoprolol	DM3UZ95	Hypertension	BA00-BA04	Approved	[604]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[605]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[606]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[607]

Drug(s) Affected By E3 ubiquitin-protein ligase CBL (CBL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[608]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[231]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[243]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[238]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[247]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]

Drug(s) Affected By C-X-C chemokine receptor type 2 (CXCR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[267]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[325]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[609]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[610]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[611]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[235]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[612]
PBI-05204	DM05WIU	Pancreatic cancer	2C10	Phase 2	[613]

Drug(s) Affected By Endothelin-1 receptor (EDNRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[350]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Fructose	DM43AN2	Vomiting	MD90	Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[230]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[252]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[614]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]

Drug(s) Affected By Platelet-activating factor receptor (PTAFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[468]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[219]
Salbutamol	DMN9CWF	Acute asthma	CA23	Approved	[615]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[616]
Alprazolam	DMC7XDN	Anxiety		Approved	[116]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[617]

Drug(s) Affected By Nuclear transcription factor Y subunit beta (NFYB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[280]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[240]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[417]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[224]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[517]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[339]

Drug(s) Affected By Pentraxin-related protein PTX3 (PTX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[591]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[618]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[219]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[330]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[331]
Bortezomib	DMNO38U	Leukemia		Approved	[514]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]

Drug(s) Affected By Hepatocyte growth factor-like protein (MST1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[619]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[177]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[420]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[223]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[620]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[517]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[621]

Drug(s) Affected By Interleukin-3 receptor subunit alpha (IL3RA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[622]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[623]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[212]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[517]
Tacedinaline	DM1Z74X	Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 2	[622]

Drug(s) Affected By Embryonic growth/differentiation factor 1 (GDF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[624]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[231]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[625]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[626]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[517]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[339]
PHENCYCLIDINE	DMQBEYX	Discovery agent	N.A.	Investigative	[627]

Drug(s) Affected By Proteasome subunit beta type-6 (PSMB6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[628]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[629]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[354]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[239]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Ardeparin	DMYRX8B	Deep vein thrombosis	BD71	Approved	[630]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[631]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[143]

Drug(s) Affected By Ephrin type-A receptor 3 (EPHA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[311]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[230]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[219]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[632]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[632]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[235]

Drug(s) Affected By cAMP-dependent protein kinase type II-beta regulatory subunit (PRKAR2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[337]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[633]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[239]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[634]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[635]

Drug(s) Affected By Nitric oxide synthase, inducible (NOS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Indomethacin	DMSC4A7	Bursitis		Approved	[263]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[411]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[636]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[175]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[637]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[638]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[123]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[639]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[388]

Drug(s) Affected By Receptor-type tyrosine-protein kinase FLT3 (FLT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[640]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[641]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[350]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[642]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[643]
Venetoclax	DM8I94Y	Chronic lymphocytic leukaemia	2A82.0	Approved	[644]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[645]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[646]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[582]

Drug(s) Affected By Sterol regulatory element-binding protein 1 (SREBF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[269]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[116]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[259]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[647]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[648]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[649]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[185]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[650]

Drug(s) Affected By Alpha-synuclein (SNCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[273]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[252]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[398]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[460]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Bortezomib	DMNO38U	Leukemia		Approved	[651]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[370]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[170]

Drug(s) Affected By Breast cancer type 1 susceptibility protein (BRCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[304]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[652]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[653]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[654]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[175]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[655]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[656]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[269]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[273]

Drug(s) Affected By Kappa-type opioid receptor (OPRK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[267]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[230]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[657]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[337]
Morphine	DMRMS0L	Advanced cancer	2A00-2F9Z	Approved	[658]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[230]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[116]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[223]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[350]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[659]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[660]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[661]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[662]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[123]
Fructose	DM43AN2	Vomiting	MD90	Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[663]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[664]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[665]

Drug(s) Affected By C-C chemokine receptor type 5 (CCR5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[558]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[666]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[667]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[668]
I3C	DMIGFOR	Breast cancer	2C60-2C65	Phase 3	[669]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[670]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[571]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[517]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[666]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[219]

Drug(s) Affected By C-C chemokine receptor type 6 (CCR6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[671]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[442]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[521]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[212]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[571]

Drug(s) Affected By Signal transducer and activator of transcription 2 (STAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[362]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[672]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[570]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[240]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[420]

Drug(s) Affected By Ephrin type-B receptor 3 (EPHB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[405]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[297]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[232]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[239]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[673]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[212]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[517]

Drug(s) Affected By Protein S100-A10 (S100A10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[230]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[674]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[675]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[293]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[293]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[676]

Drug(s) Affected By Cyclin-dependent kinases regulatory subunit 1 (CKS1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[677]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[269]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[572]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[293]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[293]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[330]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[342]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]

Drug(s) Affected By Large ribosomal subunit protein eL8 (RPL7A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[297]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[343]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[678]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[229]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[517]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[229]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[286]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[679]

Drug(s) Affected By Small ribosomal subunit protein eS25 (RPS25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[273]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[396]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[343]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[419]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[517]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[455]

Drug(s) Affected By Transcription elongation factor SPT4 (SUPT4H1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[170]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[170]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[143]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[458]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[517]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[418]

Drug(s) Affected By Tyrosine-protein kinase BTK (BTK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibrutinib	DMHZCPO	Mantle cell lymphoma	2A85.5	Approved	[680]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[681]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[429]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[682]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[539]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[596]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[339]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[275]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[219]

Drug(s) Affected By Protein CBFA2T1 (RUNX1T1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[230]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[354]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[466]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[223]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[230]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[230]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[143]
Tanespimycin	DMNLQHK	Breast cancer	2C60-2C65	Phase 2	[683]

Drug(s) Affected By Lymphotoxin-beta (LTB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[684]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[685]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[592]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[389]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[685]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[232]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[686]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[687]

Drug(s) Affected By Regulator of G-protein signaling 1 (RGS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[267]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[541]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[688]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[219]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[689]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[690]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[670]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[442]

Drug(s) Affected By Nucleoside diphosphate kinase 3 (NME3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[243]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[682]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[236]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[212]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[691]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[539]

Drug(s) Affected By Phospholipase D1 (PLD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[340]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[269]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[692]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[527]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[192]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[429]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[693]

Drug(s) Affected By Transcription factor Dp-1 (TFDP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[694]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[426]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[334]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[188]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[243]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[598]

Drug(s) Affected By Helicase-like transcription factor (HLTF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[313]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[192]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[313]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[695]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[240]

Drug(s) Affected By Na(+)/H(+) exchange regulatory cofactor NHE-RF2 (NHERF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[199]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[177]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[442]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[517]

Drug(s) Affected By Bcl-2-related protein A1 (BCL2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[696]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[554]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[395]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[697]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[219]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[698]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[699]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[554]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[466]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]

Drug(s) Affected By Cocaine- and amphetamine-regulated transcript protein (CARTPT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[700]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[625]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[223]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]

Drug(s) Affected By POU domain class 2-associating factor 1 (POU2AF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[333]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[192]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[333]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[701]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[702]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[703]

Drug(s) Affected By Anti-Muellerian hormone type-2 receptor (AMHR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[704]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[460]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[170]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[517]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[339]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[705]
PHENCYCLIDINE	DMQBEYX	Discovery agent	N.A.	Investigative	[627]

Drug(s) Affected By Serine/threonine-protein kinase LMTK1 (AATK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[350]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[243]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[420]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[212]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[706]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[707]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[339]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[283]

Drug(s) Affected By MAP kinase-activating death domain protein (MADD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[555]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[288]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[243]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[524]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[708]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[682]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[212]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[626]

Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[709]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[387]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[292]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[710]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[711]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[712]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[185]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[713]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[188]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[589]

Drug(s) Affected By Prothrombin (F2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[714]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[267]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[715]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[324]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[334]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[716]
Phytonadione	DM8HDOL	Bleeding disorder	GA20-GA21	Approved	[717]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[718]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[719]

Drug(s) Affected By Transcription factor JunB (JUNB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[150]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[497]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[185]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[273]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[231]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[720]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[721]

Drug(s) Affected By CCAAT/enhancer-binding protein beta (CEBPB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[304]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[199]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[433]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[722]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[723]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[269]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[441]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[230]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[724]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[725]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[139]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[652]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[726]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[727]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[728]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[145]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[729]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[730]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[241]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[260]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[731]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[727]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[732]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[733]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[734]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[735]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[368]

Drug(s) Affected By Signal transducer and activator of transcription 6 (STAT6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[292]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[736]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[199]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[737]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[230]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[738]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[736]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[739]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[726]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[734]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[740]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[741]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[742]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[743]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[677]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[744]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[745]

Drug(s) Affected By Signal transducer and activator of transcription 5B (STAT5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[746]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[747]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[288]
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[748]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[749]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[750]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[238]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[751]

Drug(s) Affected By Metalloproteinase inhibitor 1 (TIMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pentoxifylline	DMU3DNC	Alcoholic hepatitis	DB94.1	Approved	[116]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[752]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[753]
Selenium	DM25CGV	N. A.	N. A.	Approved	[754]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[753]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[755]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[185]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[756]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[757]

Drug(s) Affected By Metalloproteinase inhibitor 3 (TIMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[754]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[758]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[175]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[216]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[188]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[375]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]

Drug(s) Affected By Metalloproteinase inhibitor 4 (TIMP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[754]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[759]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[633]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[170]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[634]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[760]

Drug(s) Affected By Urokinase-type plasminogen activator (PLAU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[257]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[199]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[761]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[269]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[257]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[230]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[756]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[762]

Drug(s) Affected By Matrilysin (MMP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[175]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[763]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[692]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[395]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[688]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[764]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[765]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[766]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[767]

Drug(s) Affected By Polyunsaturated fatty acid 5-lipoxygenase (ALOX5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[768]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[769]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[770]
Fructose	DM43AN2	Vomiting	MD90	Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[771]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[375]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[772]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[232]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[773]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[259]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[774]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[775]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[776]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[777]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[778]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[779]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[230]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[780]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[497]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[781]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[782]
Selenium	DM25CGV	N. A.	N. A.	Approved	[754]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[758]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[783]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[513]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[784]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[785]

Drug(s) Affected By G1/S-specific cyclin-E1 (CCNE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[304]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[786]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[787]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[735]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[425]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[677]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[332]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[788]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[789]

Drug(s) Affected By Transcription factor E2F1 (E2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[790]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[304]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[786]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[791]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[368]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[425]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[684]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[269]

Drug(s) Affected By Urokinase plasminogen activator surface receptor (PLAUR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[164]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[792]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[761]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[793]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[325]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[794]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[293]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[434]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[293]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[177]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[795]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[387]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[304]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[796]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[259]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[410]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[727]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[266]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[797]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[735]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[798]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[484]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[781]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[799]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[485]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[426]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[800]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[801]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[485]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[802]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 2 (BIRC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[803]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[387]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[804]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[805]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[806]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[619]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[807]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[808]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[809]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[810]

Drug(s) Affected By Cytochrome P450 26A1 (CYP26A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[811]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[812]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[811]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[813]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[704]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[134]
Dolutegravir	DMCZGRE	Human immunodeficiency virus infection	1C62	Approved	[814]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[811]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[815]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[237]

Drug(s) Affected By Cholesterol side-chain cleavage enzyme, mitochondrial (CYP11A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[340]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[816]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[817]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[293]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[818]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[819]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[820]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[821]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[822]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[823]

Drug(s) Affected By Steroidogenic acute regulatory protein, mitochondrial (STAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[824]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[273]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[351]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[818]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[819]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[255]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[825]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[429]

Drug(s) Affected By Zinc finger protein SNAI2 (SNAI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[774]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[826]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[230]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[456]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[293]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[293]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[354]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]

Drug(s) Affected By Zinc finger protein SNAI1 (SNAI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[497]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[774]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[826]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[827]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[828]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[829]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[830]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[831]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[832]

Drug(s) Affected By Aldehyde dehydrogenase 1A1 (ALDH1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[826]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[369]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[833]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[834]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[835]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[836]

Drug(s) Affected By Polycomb complex protein BMI-1 (BMI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Ibrutinib	DMHZCPO	Mantle cell lymphoma	2A85.5	Approved	[837]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[838]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[839]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[239]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[240]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[840]

Drug(s) Affected By POU domain, class 5, transcription factor 1 (POU5F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[826]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[841]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[842]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[230]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[619]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[843]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[844]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[351]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[845]

Drug(s) Affected By Homeobox protein NANOG (NANOG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[846]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[826]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[841]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[842]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[230]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[619]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[843]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[844]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[847]

Drug(s) Affected By Insulin-induced gene 1 protein (INSIG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[340]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[440]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[519]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[555]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[848]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[216]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[555]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[288]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[293]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[294]

Drug(s) Affected By Low-density lipoprotein receptor (LDLR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[849]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[732]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[849]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[850]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[851]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[185]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[519]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[555]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[216]

Drug(s) Affected By 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[852]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[851]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[853]
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[116]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[732]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[144]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[440]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[185]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[854]

Drug(s) Affected By Methylsterol monooxygenase 1 (MSMO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[440]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[185]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[555]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[216]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[555]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[192]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[293]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]

Drug(s) Affected By Cyclin-G2 (CCNG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[164]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[441]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[230]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[164]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[273]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[375]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[294]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[294]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]

Drug(s) Affected By Ankyrin repeat and BTB/POZ domain-containing protein 3 (ABTB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[232]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[247]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[239]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[230]

Drug(s) Affected By Envoplakin-like protein (EVPLL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[420]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[855]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[856]

Drug(s) Affected By Stearoyl-CoA desaturase (SCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[648]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[857]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[857]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[267]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[311]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[857]
Fructose	DM43AN2	Vomiting	MD90	Approved	[858]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[857]

Drug(s) Affected By Leucine-rich repeat transmembrane protein FLRT2 (FLRT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[230]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[354]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[252]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[429]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[859]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[476]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[860]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[236]

Drug(s) Affected By D-3-phosphoglycerate dehydrogenase (PHGDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[554]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[269]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[554]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[216]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[294]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[294]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]

Drug(s) Affected By Ephrin-A2 (EFNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[354]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[466]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[420]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[212]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[339]

Drug(s) Affected By Sushi repeat-containing protein SRPX2 (SRPX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[519]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[216]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[354]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[429]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[633]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]

Drug(s) Affected By Kinesin-like protein KIF21B (KIF21B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[441]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[325]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[441]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[861]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[247]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[420]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]

Drug(s) Affected By Immunoglobulin superfamily member 3 (IGSF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[688]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[354]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[170]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[170]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[634]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]

Drug(s) Affected By Gamma-glutamylcyclotransferase (GGCT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[405]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[480]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[631]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[339]

Drug(s) Affected By Ectonucleoside triphosphate diphosphohydrolase 3 (ENTPD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[554]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[375]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[554]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[235]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]

Drug(s) Affected By Mediator of RNA polymerase II transcription subunit 24 (MED24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[283]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[480]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[539]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[283]

Drug(s) Affected By Short-chain dehydrogenase/reductase 3 (DHRS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[372]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[230]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[293]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[375]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[210]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[232]

Drug(s) Affected By CCN family member 5 (CCN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[497]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[269]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[554]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[554]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[554]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[862]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[863]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[417]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[864]

Drug(s) Affected By 2'-5'-oligoadenylate synthase 1 (OAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[554]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[312]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[554]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[216]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[572]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[527]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[192]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[293]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]

Drug(s) Affected By Glycoprotein hormones alpha chain (CGA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[273]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[375]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[704]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Octreotide	DMHIDCJ	Acromegaly	5A60.0	Approved	[865]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[866]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[631]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[867]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[868]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[869]

Drug(s) Affected By Lactotransferrin (LTF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[497]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[688]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[870]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[401]
Budesonide	DMJIBAW	Allergic rhinitis	CA08.0	Approved	[871]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[442]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[872]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[873]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[497]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[874]

Drug(s) Affected By Keratin, type II cytoskeletal 6B (KRT6B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[875]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[688]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[328]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[863]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[393]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[706]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]
PD-153035	DM7KJTI	Psoriasis vulgaris	EA90	Discontinued in Phase 1	[875]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[876]

Drug(s) Affected By Metallothionein-1E (MT1E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[306]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[313]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[877]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[878]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[406]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[879]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[880]

Drug(s) Affected By Guanine nucleotide-binding protein G(i) subunit alpha-2 (GNAI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[881]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[396]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]

Drug(s) Affected By Neprilysin (MME)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[512]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[231]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[676]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[882]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[338]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]

Drug(s) Affected By Galectin-1 (LGALS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[497]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[321]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[834]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[273]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[468]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[883]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[884]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[354]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[278]

Drug(s) Affected By Pro-cathepsin H (CTSH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[436]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[555]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[834]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[325]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[231]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[331]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[885]

Drug(s) Affected By Coiled-coil domain-containing protein 159 (CCDC159)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[420]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[235]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[339]

Drug(s) Affected By Ras-related C3 botulinum toxin substrate 2 (RAC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[886]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[321]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[216]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[230]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[395]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[460]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Bortezomib	DMNO38U	Leukemia		Approved	[226]

Drug(s) Affected By Fumarylacetoacetase (FAH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[519]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[429]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[331]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]

Drug(s) Affected By Homeobox protein Hox-B9 (HOXB9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[199]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[403]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[887]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[887]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Dabigatran	DMDI6R4	Stroke	8B20	Approved	[887]
Abacavir	DMMN36E	Human immunodeficiency virus infection	1C62	Approved	[887]

Drug(s) Affected By Ganglioside GM2 activator (GM2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[555]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[398]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[888]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[372]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[212]

Drug(s) Affected By Insulin-like growth factor-binding protein 2 (IGFBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[519]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[889]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[890]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[398]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]

Drug(s) Affected By Keratin, type I cytoskeletal 15 (KRT15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[684]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[180]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[688]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[294]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[294]

Drug(s) Affected By Small proline-rich protein 2D (SPRR2D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[304]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[480]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[224]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]

Drug(s) Affected By Protein S100-A2 (S100A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[254]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[688]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[219]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[232]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[891]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]

Drug(s) Affected By Neurotensin receptor type 1 (NTSR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[456]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[892]
Isoflavone	DM7U58J	N. A.	N. A.	Phase 4	[893]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]
NEUROTENSIN	DM27WCE	Discovery agent	N.A.	Investigative	[894]
Hexadecanoic acid	DMWUXDZ	Discovery agent	N.A.	Investigative	[895]

Drug(s) Affected By Caspase-14 (CASP14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[688]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[243]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[699]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[682]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[418]
PHENCYCLIDINE	DMQBEYX	Discovery agent	N.A.	Investigative	[896]

Drug(s) Affected By Long-chain-fatty-acid--CoA ligase 1 (ACSL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[350]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[185]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[230]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[897]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[898]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[294]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[294]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[294]

Drug(s) Affected By Interferon alpha-inducible protein 27, mitochondrial (IFI27)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[554]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[554]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[192]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[688]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[252]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[899]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[219]

Drug(s) Affected By Cathelicidin antimicrobial peptide (CAMP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[395]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[900]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[901]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[902]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[239]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[480]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[902]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[903]

Drug(s) Affected By Epithelial membrane protein 1 (EMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[257]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[257]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[180]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[230]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[231]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[192]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[293]

Drug(s) Affected By ATP synthase subunit epsilon, mitochondrial (ATP5F1E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[288]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[904]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[352]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[328]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[223]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[905]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[339]

Drug(s) Affected By 3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (HSD17B7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[906]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[440]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[185]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[216]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[192]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]

Drug(s) Affected By Ribose-phosphate pyrophosphokinase 1 (PRPS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[273]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[217]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[294]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[291]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[907]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[480]

Drug(s) Affected By Rho-related GTP-binding protein RhoE (RND3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[306]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[369]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[216]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[230]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[908]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[294]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[294]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[354]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]

Drug(s) Affected By Small ribosomal subunit protein eS24 (RPS24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[230]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[240]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[230]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[230]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[394]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[909]

Drug(s) Affected By Keratin, type II cuticular Hb5 (KRT85)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[254]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[421]

Drug(s) Affected By Large neutral amino acids transporter small subunit 1 (SLC7A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[164]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[266]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[312]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[910]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[216]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[230]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[272]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[164]

Drug(s) Affected By DNA-binding protein inhibitor ID-2 (ID2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[340]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[296]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[185]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[911]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[441]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[313]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[325]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[296]

Drug(s) Affected By Paired box protein Pax-8 (PAX8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[541]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[912]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[913]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[222]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[480]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[470]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[631]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[212]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[914]

Drug(s) Affected By Cytochrome P450 4F3 (CYP4F3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[267]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[185]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[321]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[216]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[134]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[219]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[915]

Drug(s) Affected By Transcription intermediary factor 1-beta (TRIM28)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[297]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[916]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[283]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Haloperidol	DM96SE0	Delirium		Approved	[297]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[297]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[297]

Drug(s) Affected By Melatonin-related receptor (GPR50)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[375]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[457]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[420]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[917]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[918]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[855]

Drug(s) Affected By Endoplasmic reticulum membrane sensor NFE2L1 (NFE2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[266]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[305]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[359]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[280]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[291]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[919]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[920]

Drug(s) Affected By Transmembrane glycoprotein NMB (GPNMB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[269]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[692]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[234]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[294]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[294]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[219]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[232]

Drug(s) Affected By C3a anaphylatoxin chemotactic receptor (C3AR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[688]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[337]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[247]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[479]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[240]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[479]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[918]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[679]

Drug(s) Affected By Protein Aster-B (GRAMD1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[337]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[420]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[918]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[702]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[909]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[339]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[283]

Drug(s) Affected By Interferon-induced protein 44-like (IFI44L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[554]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[554]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[527]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[192]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[362]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[252]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[230]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[219]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]

Drug(s) Affected By SH3 domain-containing protein 19 (SH3D19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[350]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[921]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[633]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[396]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]

Drug(s) Affected By Late cornified envelope protein 1B (LCE1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[922]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[219]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[418]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[219]

Drug(s) Affected By Terminal nucleotidyltransferase 4A (TENT4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[247]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[240]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Brilinta	DMBR01X	Acute coronary syndrome	BA41	Approved	[923]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[143]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[339]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[350]

Drug(s) Affected By Keratin, type II cytoskeletal 80 (KRT80)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[257]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[257]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[527]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[293]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[293]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[354]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[232]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[331]

Drug(s) Affected By TMF-regulated nuclear protein 1 (TRNP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[828]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[230]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[398]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[232]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[239]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[240]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[443]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[522]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[230]

Drug(s) Affected By Olfactomedin-4 (OLFM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[828]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[232]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[924]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[925]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[925]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[926]

Drug(s) Affected By Solute carrier family 25 member 48 (SLC25A48)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[927]
Maleic Acid	DM4L0R7	Discovery agent	N.A.	Investigative	[928]

Drug(s) Affected By Activity-regulated cytoskeleton-associated protein (ARC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[237]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[420]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[212]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[702]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[929]

Drug(s) Affected By 5'-deoxynucleotidase HDDC2 (HDDC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[293]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[293]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[239]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[223]

Drug(s) Affected By Low-density lipoprotein receptor class A domain-containing protein 3 (LDLRAD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[231]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[331]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[247]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[328]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[930]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[339]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[230]

Drug(s) Affected By Neuronal PAS domain-containing protein 3 (NPAS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[350]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[311]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[472]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[931]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[350]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[472]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[478]

Drug(s) Affected By Prominin-2 (PROM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[192]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[688]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[239]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[706]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[339]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[926]

Drug(s) Affected By Synaptopodin (SYNPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[231]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[354]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[337]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[239]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[223]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[932]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[143]

Drug(s) Affected By Cilia- and flagella-associated protein 43 (CFAP43)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[212]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[596]

Drug(s) Affected By Protein FAM83F (FAM83F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[235]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[418]

Drug(s) Affected By Interferon-induced protein 44 (IFI44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[554]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[692]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[554]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[527]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[704]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[899]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[219]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[554]
Bortezomib	DMNO38U	Leukemia		Approved	[226]

Drug(s) Affected By Retinoic acid early transcript 1E (RAET1E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[331]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[918]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[855]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[418]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[933]

Drug(s) Affected By Glucose-6-phosphate exchanger SLC37A2 (SLC37A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[910]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[522]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[934]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[212]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[418]

Drug(s) Affected By Prospero homeobox protein 1 (PROX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[324]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[231]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[252]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[237]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[935]

Drug(s) Affected By Phosphatidate cytidylyltransferase 1 (CDS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[199]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[375]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[354]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[472]

Drug(s) Affected By Solute carrier organic anion transporter family member 2A1 (SLCO2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[936]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[267]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[910]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[937]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[519]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[232]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[938]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[701]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[939]

Drug(s) Affected By SH3 domain-containing kinase-binding protein 1 (SH3KBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[249]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[283]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[230]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[527]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[375]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[398]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[297]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[239]

Drug(s) Affected By Androgen-dependent TFPI-regulating protein (ADTRP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[216]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[527]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[354]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[539]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[933]

Drug(s) Affected By Gasdermin-A (GSDMA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[273]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[480]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[235]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[909]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[418]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[940]

Drug(s) Affected By SH3 and cysteine-rich domain-containing protein (STAC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[688]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[466]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[223]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[236]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]

Drug(s) Affected By Cell growth regulator with EF hand domain protein 1 (CGREF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[457]
Bortezomib	DMNO38U	Leukemia		Approved	[651]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[223]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[212]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[223]

Drug(s) Affected By Melanophilin (MLPH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[354]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[921]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[941]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[942]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[328]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[522]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]

Drug(s) Affected By Protein Niban 1 (NIBAN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[943]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[527]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[375]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[336]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[398]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[390]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[232]

Drug(s) Affected By Tubulointerstitial nephritis antigen-like (TINAGL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[329]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[375]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[420]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[235]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[339]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[350]

Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 19 (ADAM19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[192]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[375]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[354]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[232]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[463]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[170]

Drug(s) Affected By Transmembrane protein 222 (TMEM222)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[396]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[170]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[170]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[143]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[283]

Drug(s) Affected By Beta-defensin 129 (DEFB129)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[944]

Drug(s) Affected By CXADR-like membrane protein (CLMP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[527]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[192]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[398]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[420]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[918]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[350]

Drug(s) Affected By Protein S100-A14 (S100A14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[828]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[232]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[945]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[417]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[864]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]

Drug(s) Affected By SH2 domain-containing protein 2A (SH2D2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[231]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[420]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[236]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[539]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[876]
PHENCYCLIDINE	DMQBEYX	Discovery agent	N.A.	Investigative	[946]

Drug(s) Affected By Triggering receptor expressed on myeloid cells 1 (TREM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[688]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[704]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[866]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[947]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[948]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[353]
Nickel chloride	DMI12Y8	Discovery agent	N.A.	Investigative	[948]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[940]

Drug(s) Affected By Serine palmitoyltransferase 3 (SPTLC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[232]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[598]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[240]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]

Drug(s) Affected By G patch domain-containing protein 2 (GPATCH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[219]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[480]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[223]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[212]

Drug(s) Affected By DNA damage-inducible transcript 4 protein (DDIT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[306]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[340]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[368]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[888]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[949]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[313]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[244]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[15]

Drug(s) Affected By Protocadherin Fat 2 (FAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[950]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[212]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[931]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[418]

Drug(s) Affected By Myoferlin (MYOF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[230]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[395]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[892]

Drug(s) Affected By Coiled-coil domain-containing protein 167 (CCDC167)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[170]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[247]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[431]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[539]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[472]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[418]

Drug(s) Affected By Cysteine-rich C-terminal protein 1 (CRCT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[185]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[527]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[354]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[337]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[331]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[951]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[418]

Drug(s) Affected By STEAP1 protein (STEAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[398]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[232]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[330]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[240]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[952]

Drug(s) Affected By Protein mono-ADP-ribosyltransferase PARP4 (PARP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[249]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[296]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[240]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[443]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Lithium	DMZ3OU6	Bipolar disorder	6A60	Phase 2	[765]

Drug(s) Affected By Hippocalcin-like protein 4 (HPCAL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[199]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[232]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[480]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[953]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[235]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[223]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[350]

Drug(s) Affected By Angiopoietin-4 (ANGPT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[350]

Drug(s) Affected By Kallikrein-5 (KLK5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[688]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[235]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[631]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]
Citrate	DM37NYK	N. A.	N. A.	Preclinical	[954]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[418]

Drug(s) Affected By Hairy/enhancer-of-split related with YRPW motif protein 1 (HEY1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[955]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[434]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[331]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[598]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]

Drug(s) Affected By Adhesion G-protein coupled receptor G1 (ADGRG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[269]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[230]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[688]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[956]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[689]

Drug(s) Affected By Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[824]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[957]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[958]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[816]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[959]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[959]
Pyruvic acid	DM7Q41G	Malnutrition	5B50-5B71	Approved	[960]
Topiramate	DM82Z30	Alcohol dependence	6C40.2	Approved	[961]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[961]
ABIRATERONE	DM8V75C	Prostate cancer	2C82.0	Approved	[962]

Drug(s) Affected By Steroidogenic factor 1 (NR5A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[820]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[963]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[964]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[965]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[966]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]
27-hydroxycholesterol	DM2L6OZ	Discovery agent	N.A.	Investigative	[967]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[968]
Forskolin	DM6ITNG	Solid tumour/cancer	2A00-2F9Z	Investigative	[969]

Drug(s) Affected By Histone deacetylase 1 (HDAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[266]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[199]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[805]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[970]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[971]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[134]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[821]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]

Drug(s) Affected By Histone deacetylase 7 (HDAC7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[283]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[972]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[815]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[973]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[223]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[974]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[539]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[855]

Drug(s) Affected By Histone deacetylase 2 (HDAC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[975]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[976]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[287]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[971]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[972]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[429]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[564]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[205]

Drug(s) Affected By Early growth response protein 1 (EGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[306]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[732]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[199]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[655]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[123]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[639]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[462]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[257]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[273]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[125]

Drug(s) Affected By ETS domain-containing protein Elk-1 (ELK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[977]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[266]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[978]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[979]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[388]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[980]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[252]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[226]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]

Drug(s) Affected By 11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[924]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[981]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[293]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[293]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[982]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[351]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[983]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[984]
Oxymetholone	DMFXUT8	Aplastic anemia	3A70	Approved	[985]

Drug(s) Affected By Neuronal acetylcholine receptor subunit alpha-9 (CHRNA9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[231]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[354]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[480]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[236]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[223]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[918]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[418]

Drug(s) Affected By RNA binding protein fox-1 homolog 3 (RBFOX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[199]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[799]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[230]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[192]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[986]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[239]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[230]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[230]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]

Drug(s) Affected By Dynamin-1-like protein (DNM1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[987]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[988]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[886]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[989]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[990]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[352]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[987]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[991]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[992]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[731]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[993]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[412]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[733]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[305]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[994]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[995]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[996]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[997]

Drug(s) Affected By Phospholipid-transporting ATPase ABCA1 (ABCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[998]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[999]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[440]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[185]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1000]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[1001]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1002]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[1003]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[650]

Drug(s) Affected By Interleukin-33 (IL33)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[527]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[688]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[331]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[1004]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[1005]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[483]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[863]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[1006]

Drug(s) Affected By Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[1007]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[726]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[1008]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[742]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[1009]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1010]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[416]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[249]
Selenium	DM25CGV	N. A.	N. A.	Approved	[754]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[1011]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[273]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[241]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[1012]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[416]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[1012]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[1013]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[266]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[1014]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1015]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1016]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1017]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[416]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[1013]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1018]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[325]
Selenium	DM25CGV	N. A.	N. A.	Approved	[1019]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[145]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[146]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1020]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[267]

Drug(s) Affected By Platelet-derived growth factor subunit B (PDGFB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[1021]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[1022]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[267]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1023]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[1024]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[1025]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1024]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[859]

Drug(s) Affected By Beta-nerve growth factor (NGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[694]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[267]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[1026]
MCI-186	DM8ZHP1	Amyotrophic lateral sclerosis	8B60.0	Approved	[1027]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[375]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[1028]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[1029]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[1030]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[1031]

Drug(s) Affected By Lutropin subunit beta (LHB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[1032]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[1033]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1034]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[1035]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[1036]
Alprazolam	DMC7XDN	Anxiety		Approved	[1037]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Norethindrone acetate	DMDGCQP	N. A.	N. A.	Approved	[1033]
Metoclopramide	DMFA5MY	Nausea	MD90	Approved	[1035]
Cetrorelix	DMFD9Q6	Ovarian stimulation	LB45.1	Approved	[1038]

Drug(s) Affected By Prolactin (PRL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[1039]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[1040]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[1041]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[1042]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[267]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[1043]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[1044]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[1045]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[1046]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[1047]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[1048]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[1049]
Fructose	DM43AN2	Vomiting	MD90	Approved	[116]
Ketoprofen	DMRKXPT	Bursitis		Approved	[116]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[1050]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[1051]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[1052]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[781]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[1053]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[782]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[292]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[151]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1054]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[152]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[153]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[152]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[1055]
Selenium	DM25CGV	N. A.	N. A.	Approved	[591]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[1056]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[1057]

Drug(s) Affected By Osteocalcin (BGLAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[1058]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[1059]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1060]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1061]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[1062]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[1063]
Falecalcitrol	DMBI9ZJ	Hyperparathyroidism	5A51	Approved	[1064]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[1065]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[405]

Drug(s) Affected By Estrogen receptor (ESR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1066]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[652]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1067]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1068]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[742]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[777]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1069]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1070]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[1068]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[1071]

Drug(s) Affected By Interstitial collagenase (MMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[694]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1072]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[1073]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[1074]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[175]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1075]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1076]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[178]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1077]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[325]

Drug(s) Affected By RAF proto-oncogene serine/threonine-protein kinase (RAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[977]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1078]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1079]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1080]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[273]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[589]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1081]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[1026]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[1082]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[434]

Drug(s) Affected By Granulocyte-macrophage colony-stimulating factor (CSF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[599]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1083]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[123]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1084]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[1085]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[1086]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[192]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[1087]
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[1088]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[1089]

Drug(s) Affected By High affinity nerve growth factor receptor (NTRK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1090]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[231]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[1091]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[337]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[1092]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[239]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[223]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[236]

Drug(s) Affected By Integrin beta-3 (ITGB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1093]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[1094]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1095]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[764]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[908]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[1096]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[931]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[863]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[554]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[1097]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[304]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[149]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[1098]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[151]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[782]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[1055]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[1099]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[554]

Drug(s) Affected By Integrin beta-1 (ITGB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[292]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[259]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[260]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[266]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[575]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[684]
Fructose	DM43AN2	Vomiting	MD90	Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[779]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[628]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[1100]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[739]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[424]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[727]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[266]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[146]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[425]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[1101]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1102]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1103]

Drug(s) Affected By Progesterone receptor (PGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[1104]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[1105]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1106]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[1107]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[1108]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[1109]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[1110]
Goserelin	DMAT8CG	Breast cancer	2C60-2C65	Approved	[1111]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[1112]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]

Drug(s) Affected By Cyclin-dependent kinase 1 (CDK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[694]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[1113]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[992]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Selenium	DM25CGV	N. A.	N. A.	Approved	[1019]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[733]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[654]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[175]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[684]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1103]

Drug(s) Affected By Tyrosine 3-monooxygenase (TH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zonisamide	DM0DTF7	Alcohol dependence	6C40.2	Approved	[1114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1115]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1116]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[1117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[354]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[429]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[986]
Methamphetamine	DMPM4SK	Anxiety		Approved	[1118]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[1119]

Drug(s) Affected By Neurofilament medium polypeptide (NEFM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[241]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[350]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[541]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[230]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[1120]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[232]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[330]
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[1030]

Drug(s) Affected By Involucrin (IVL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[1121]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[259]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1122]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[254]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[922]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[1121]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[1123]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[219]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[1124]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[259]

Drug(s) Affected By Heat shock protein HSP 90-alpha (HSP90AA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1125]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[292]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[497]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1054]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1126]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[310]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 16 (NGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[304]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[1127]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[199]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1128]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[230]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1129]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[1129]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[688]
Oxaprozin	DM9UB0P	Osteoarthritis	FA00-FA05	Approved	[1130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]

Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1072]
Selenium	DM25CGV	N. A.	N. A.	Approved	[754]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1131]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1132]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1133]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[912]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[216]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[756]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[757]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1134]

Drug(s) Affected By Stromelysin-1 (MMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[116]
Fluvastatin	DM4MDJY	Arteriosclerosis	BD40	Approved	[116]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[116]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[116]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[292]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[1074]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[536]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1135]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[178]

Drug(s) Affected By Integrin alpha-IIb (ITGA2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1136]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[257]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[325]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[1136]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[1096]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[257]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Abciximab	DMJO6GV	Acute disease		Approved	[116]
Tirofiban	DMQG17S	Acute coronary syndrome	BA41	Approved	[116]
Eptifibatide	DMQXTJS	Acute cardiac ischemic events	BA40.Z	Approved	[116]

Drug(s) Affected By Fibroblast growth factor 2 (FGF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1137]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[241]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[1138]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[1139]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[1140]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1141]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[244]
Isradipine	DMA5XGH	Hypertension	BA00-BA04	Approved	[1142]
Valdecoxib	DMAY7H4	Osteoarthritis	FA00-FA05	Approved	[1143]

Drug(s) Affected By Dopamine beta-hydroxylase (DBH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[1144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[1145]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Bromocriptine	DMVE3TK	Acromegaly	5A60.0	Approved	[1145]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[1146]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[1147]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[1148]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[212]

Drug(s) Affected By Platelet-derived growth factor receptor beta (PDGFRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[216]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[1025]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[337]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[460]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[330]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[795]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[1149]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1150]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[1151]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[116]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[304]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[796]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[409]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[1051]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[139]

Drug(s) Affected By Osteopontin (SPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[1152]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[497]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1034]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1153]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1154]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1155]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[372]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[230]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[272]

Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[1156]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[1157]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1158]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[360]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[1159]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[1160]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1161]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[1162]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[656]

Drug(s) Affected By Phenylethanolamine N-methyltransferase (PNMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[932]
Bortezomib	DMNO38U	Leukemia		Approved	[226]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[934]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[235]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[478]

Drug(s) Affected By Aromatase (CYP19A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[1163]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[1164]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[1165]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[497]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[1165]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[267]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[957]
Bifonazole	DM3KN7V	Fungal infection	1F29-1F2F	Approved	[1166]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1167]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[1165]

Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[1168]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[422]
Selenium	DM25CGV	N. A.	N. A.	Approved	[1019]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1169]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[175]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1170]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[1171]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1103]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[269]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]

Drug(s) Affected By Proliferating cell nuclear antigen (PCNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[304]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[1013]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[249]
Selenium	DM25CGV	N. A.	N. A.	Approved	[1019]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[144]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[787]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[797]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[175]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[684]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[1172]

Drug(s) Affected By Proto-oncogene tyrosine-protein kinase Src (SRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosutinib	DMTI8YE	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[1173]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1174]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[267]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1175]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[273]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[1176]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[1177]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[764]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[764]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]

Drug(s) Affected By Lysosome-associated membrane glycoprotein 2 (LAMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[805]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[230]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[1178]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[432]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[631]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[230]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[1179]

Drug(s) Affected By Elongation factor 2 (EEF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[444]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[1180]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[524]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[451]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[860]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1181]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[212]

Drug(s) Affected By 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[350]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[216]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[293]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[293]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[223]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[1182]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[1183]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[460]
Hexachlorophene	DMLKSE0	Bacterial infection	1A00-1C4Z	Approved	[1184]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[823]

Drug(s) Affected By 17-beta-hydroxysteroid dehydrogenase type 1 (HSD17B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[906]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Metyrapone	DMI7FVQ	Cushing disease	5A70	Approved	[1185]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[1186]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[823]
Dutasteride	DMQ4TJK	Benign prostatic hyperplasia	GA90	Approved	[1187]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[1188]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[823]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[906]

Drug(s) Affected By Neutrophil cytosol factor 1 (NCF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[889]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[1190]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1191]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[247]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[289]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[483]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[224]

Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[694]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[1113]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[260]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Selenium	DM25CGV	N. A.	N. A.	Approved	[1019]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[733]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[735]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[1192]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[305]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[369]

Drug(s) Affected By Folate receptor alpha (FOLR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1193]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[232]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[941]
Bortezomib	DMNO38U	Leukemia		Approved	[226]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[464]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[634]

Drug(s) Affected By Protein kinase C alpha type (PRKCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1194]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1195]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[185]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[230]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[277]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[1196]

Drug(s) Affected By Neuronal acetylcholine receptor subunit beta-2 (CHRNB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[362]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Atropine	DMEN6X7	Organophosphate poisoning	NE6Z	Approved	[1197]
Galantamine	DMEO794	Alzheimer disease	8A20	Approved	[1197]
Rivastigmine	DMG629M	Alzheimer disease	8A20	Approved	[1197]
Scopolamine	DMOM8AL	Addictive disorder	6C50-6C5Z	Approved	[1197]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[420]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[1198]
CYTISINE	DMUF0BJ	Tobacco dependence	6C4A.2	Phase 3	[1199]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[306]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[732]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[305]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[622]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[684]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[1200]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[519]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[313]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[1031]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[572]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[416]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[553]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[266]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1201]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[263]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[433]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1202]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[426]

Drug(s) Affected By Cyclin-A2 (CCNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[977]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[1113]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[1013]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[732]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[787]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[425]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[369]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[684]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[1203]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]

Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[1204]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[157]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[158]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[146]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[449]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[1205]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[1206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1207]

Drug(s) Affected By Brain-derived neurotrophic factor (BDNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[1208]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[497]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1209]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Bupivacaine	DM4PRFC	Anaesthesia	9A78.6	Approved	[1210]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1211]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[231]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[375]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[354]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]

Drug(s) Affected By Endothelial transcription factor GATA-2 (GATA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[249]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[269]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[230]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1095]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[315]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[375]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[282]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[259]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[732]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[412]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[1212]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[661]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1154]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1213]
Fructose	DM43AN2	Vomiting	MD90	Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[259]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[441]

Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[116]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[387]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[292]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[151]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[799]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[1214]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1215]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1216]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[489]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]

Drug(s) Affected By Serum paraoxonase/arylesterase 1 (PON1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[1217]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1218]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[1219]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[1220]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1221]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1222]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[230]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[1223]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1224]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[1217]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1225]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[1226]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[574]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[1051]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[1227]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[1228]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[1229]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1230]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[1231]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1232]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1233]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[1226]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[1234]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[1235]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[1236]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1225]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[116]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[292]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[1051]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[1227]

Drug(s) Affected By G1/S-specific cyclin-D2 (CCND2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[249]
Selenium	DM25CGV	N. A.	N. A.	Approved	[1019]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[175]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1103]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1237]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1238]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[730]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[697]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[354]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]

Drug(s) Affected By Neuronal acetylcholine receptor subunit alpha-3 (CHRNA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[223]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[236]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[230]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[230]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[855]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[339]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[621]

Drug(s) Affected By Aryl hydrocarbon receptor (AHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[497]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1239]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[1240]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[1241]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1242]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1243]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[1244]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[1245]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1224]

Drug(s) Affected By Neuronal acetylcholine receptor subunit alpha-7 (CHRNA7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[1246]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[1247]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Carbachol	DMX9K8F	Glaucoma/ocular hypertension	9C61	Approved	[1248]
Cotinine	DMCEZ1B	Insecticide	N.A.	Approved	[1247]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[212]
GTS-21	DMEN5KA	Parkinson disease	8A00.0	Phase 2	[1247]

Drug(s) Affected By Pigment epithelium-derived factor (SERPINF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[519]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[230]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[688]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[1249]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[1249]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[398]

Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[116]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[292]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[495]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1250]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[1251]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1252]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[199]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1253]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[1254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1175]

Drug(s) Affected By Reduced folate transporter (SLC19A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[1255]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[1256]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[1256]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[1257]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1257]
Atenolol	DMNKG1Z	Angina pectoris	BA40	Approved	[1257]

Drug(s) Affected By Neuronal acetylcholine receptor subunit alpha-4 (CHRNA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[350]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Atropine	DMEN6X7	Organophosphate poisoning	NE6Z	Approved	[1197]
Galantamine	DMEO794	Alzheimer disease	8A20	Approved	[1197]
Rivastigmine	DMG629M	Alzheimer disease	8A20	Approved	[1197]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[1258]
Scopolamine	DMOM8AL	Addictive disorder	6C50-6C5Z	Approved	[1197]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[239]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1259]

Drug(s) Affected By Collagenase 3 (MMP13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[1260]
Clindamycin	DM15HL8	Acne vulgaris	ED80	Approved	[1261]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[1260]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[684]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[1262]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[1263]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[234]
Doxycycline	DM7ICNU	Acne vulgaris	ED80	Approved	[1261]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[434]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[1264]

Drug(s) Affected By ATP-binding cassette sub-family G member 1 (ABCG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[999]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[185]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[1265]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[231]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[294]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[294]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[294]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[441]

Drug(s) Affected By C-X-C chemokine receptor type 3 (CXCR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[116]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[521]
MLN4924	DMP36KD	Myelodysplastic syndrome	2A37	Phase 3	[1266]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[948]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[706]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[219]
Nickel chloride	DMI12Y8	Discovery agent	N.A.	Investigative	[948]

Drug(s) Affected By Adenosine 5'-monophosphoramidase HINT1 (HINT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[266]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[219]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[342]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[240]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[1267]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
EXISULIND	DMBY56U	Colorectal cancer	2B91.Z	Phase 3	[1268]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[1269]

Drug(s) Affected By Oxysterols receptor LXR-beta (NR1H2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1270]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[563]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Gemfibrozil	DMD8Q3J	Hyperlipidaemia	5C80	Approved	[1271]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[1271]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[1183]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[1271]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[1272]

Drug(s) Affected By Histone H2B type 1-D (H2BC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[249]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[269]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[216]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[445]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[293]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[293]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[405]

Drug(s) Affected By Interleukin-2 (IL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sirolimus	DMGW1ID	Advanced cancer	2A00-2F9Z	Approved	[116]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[155]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[600]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[1273]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[1274]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[1275]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[737]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[1276]
Fentanyl	DM8WAHT	Analgesia	MB40.8	Approved	[520]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[1277]

Drug(s) Affected By C-X-C chemokine receptor type 4 (CXCR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[259]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[205]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[554]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1154]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[1244]
Carfilzomib	DM48K0X	Multiple myeloma	2A83	Approved	[1278]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[554]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1279]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[595]

Drug(s) Affected By Ubiquitin-ribosomal protein eS31 fusion protein (RPS27A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[360]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[273]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[288]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[297]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[1280]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[328]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[223]

Drug(s) Affected By Casein kinase II subunit alpha (CSNK2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[305]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1281]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[305]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[1282]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[1283]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]

Drug(s) Affected By Histone H3.1 (H3C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[304]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[369]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[234]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[15]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[293]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[293]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[354]

Drug(s) Affected By Cytochrome c (CYCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[292]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[1284]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1285]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[410]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1158]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[1286]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[267]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1287]
Pefloxacin	DM49IGF	Gonococcal urethritis	1A70.0Y	Approved	[1288]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[292]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[139]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[654]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1202]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[489]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1289]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[1290]

Drug(s) Affected By Protein kinase C zeta type (PRKCZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[192]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[1291]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[239]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[240]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[939]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Carbachol	DMX9K8F	Glaucoma/ocular hypertension	9C61	Approved	[1292]

Drug(s) Affected By Tight junction protein ZO-1 (TJP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[1059]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[266]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[175]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[231]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1293]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[1294]

Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[1051]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[259]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[1295]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[513]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[1296]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1154]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[639]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[259]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[1297]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[1298]

Drug(s) Affected By Oxysterols receptor LXR-alpha (NR1H3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[312]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[134]
Gemfibrozil	DMD8Q3J	Hyperlipidaemia	5C80	Approved	[1271]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1299]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[1271]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[1300]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[1183]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[1301]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[157]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1302]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[340]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[1127]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[305]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[175]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[269]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[555]

Drug(s) Affected By Interleukin-18 (IL18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[292]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[266]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[267]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1303]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1304]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[1305]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[354]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[764]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[1306]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[764]

Drug(s) Affected By Histone RNA hairpin-binding protein (SLBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[350]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[249]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[368]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[269]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[192]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[368]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[598]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[368]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[368]

Drug(s) Affected By Neuronal acetylcholine receptor subunit alpha-6 (CHRNA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[403]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[909]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[219]

Drug(s) Affected By BDNF/NT-3 growth factors receptor (NTRK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[782]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1307]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[216]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[234]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[1308]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[354]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[1309]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[232]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[370]

Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[1310]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1311]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[1312]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[1312]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1313]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1314]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[1172]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1154]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[440]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[1205]

Drug(s) Affected By Scavenger receptor class B member 1 (SCARB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1315]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1316]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[1317]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[185]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[1003]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1318]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[563]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[134]

Drug(s) Affected By NACHT, LRR and PYD domains-containing protein 3 (NLRP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[292]
Selenium	DM25CGV	N. A.	N. A.	Approved	[591]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1303]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1304]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[192]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[1319]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[1320]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1321]
Atropine	DMEN6X7	Organophosphate poisoning	NE6Z	Approved	[1322]

Drug(s) Affected By Flavin-containing monooxygenase 3 (FMO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Perazine	DM2AOTZ	Psychotic disorder	6A20-6A25	Approved	[1323]
Almogran	DM7I64Z	Migraine	8A80	Approved	[1324]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[1325]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[1326]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1327]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[1328]

Drug(s) Affected By Regulatory-associated protein of mTOR (RPTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[350]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[1329]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[221]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[226]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[1330]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[205]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[239]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[1331]

Drug(s) Affected By LysM and putative peptidoglycan-binding domain-containing protein 3 (LYSMD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[339]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[283]

Drug(s) Affected By Tyrosine-protein kinase JAK2 (JAK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Momelotinib	DMF98Q0	Myelofibrosis	2A20.2	Approved	[1332]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[164]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[340]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[1333]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[164]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[1334]

Drug(s) Affected By Pleckstrin homology domain-containing family G member 1 (PLEKHG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[273]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[219]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[331]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[211]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[230]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]

Drug(s) Affected By Choline O-acetyltransferase (CHAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[350]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[986]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[986]
Scopolamine	DMOM8AL	Addictive disorder	6C50-6C5Z	Approved	[1335]
Methamphetamine	DMPM4SK	Anxiety		Approved	[1336]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[235]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[275]
2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE	DMNQL17	Discovery agent	N.A.	Investigative	[1337]
Elaidoylamide	DMP8VDT	Discovery agent	N.A.	Investigative	[1338]

Drug(s) Affected By Solute carrier family 22 member 2 (SLC22A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[1339]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[1340]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1340]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[1341]
Lamivudine	DMI347A	Chronic HBV infection	1E51.0Z	Approved	[1342]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[1341]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1343]
Trospium chloride	DM32XZT	Discovery agent	N.A.	Approved	[1344]
Phenoxybenzamine	DM8KSQH	Malignant essential hypertension	BA00	Approved	[1345]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]

Drug(s) Affected By Neuronal acetylcholine receptor subunit alpha-5 (CHRNA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[219]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1346]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[132]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[166]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[1347]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[223]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[1348]

Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[116]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[1152]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[1138]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[259]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1060]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[888]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[1349]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[1350]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1351]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1352]

Drug(s) Affected By Plastin-2 (LCP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[244]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[822]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[930]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[232]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[233]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[239]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[227]

Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (PIK3CB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[241]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[350]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[224]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1353]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[208]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[209]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[169]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[228]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[224]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[1354]

Drug(s) Affected By Neuronal acetylcholine receptor subunit alpha-2 (CHRNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[293]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[293]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[193]
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[1355]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[1355]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Nicotinic acetylcholine receptor (nAChR)	TTJSZTB	NOUNIPROTAC	Antagonist	[4]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[5]
Cytochrome P450 2E1 (CYP2E1)	DEVDYN7	CP2E1_HUMAN	Substrate	[6]
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Substrate	[5]
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Substrate	[5]
Cytochrome P450 1A1 (CYP1A1)	DE6OQ3W	CP1A1_HUMAN	Substrate	[5]
UDP-glucuronosyltransferase 1A1 (UGT1A1)	DEYGVN4	UD11_HUMAN	Substrate	[7]
Mephenytoin 4-hydroxylase (CYP2C19)	DEGTFWK	CP2CJ_HUMAN	Substrate	[5]
Cytochrome P450 2A6 (CYP2A6)	DEJVYAZ	CP2A6_HUMAN	Substrate	[8]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Substrate	[5]
Cytochrome P450 2B6 (CYP2B6)	DEPKLMQ	CP2B6_HUMAN	Substrate	[9]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Substrate	[5]
Cytochrome P450 2A13 (CYP2A13)	DEXZA9U	CP2AD_HUMAN	Substrate	[10]
Nicotinate dehydrogenase (nicA)	DE4AMLP	NICA_PSEPK	Substrate	[11]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)	OTHF4H9U	DHI2_HUMAN	Gene/Protein Processing	[12]
17-beta-hydroxysteroid dehydrogenase type 1 (HSD17B1)	OT6EBDHM	DHB1_HUMAN	Gene/Protein Processing	[13]
2'-5'-oligoadenylate synthase 1 (OAS1)	OT8ZLOCY	OAS1_HUMAN	Gene/Protein Processing	[14]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1)	OTNAZVKB	3BHS1_HUMAN	Gene/Protein Processing	[13]
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)	OTRT3F3U	HMDH_HUMAN	Gene/Protein Processing	[15]
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7 (HSD17B7)	OTV7VOV3	DHB7_HUMAN	Gene/Protein Processing	[14]
5'-deoxynucleotidase HDDC2 (HDDC2)	OTSO0JP4	HDDC2_HUMAN	Gene/Protein Processing	[14]
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[16]
Activity-regulated cytoskeleton-associated protein (ARC)	OTN2QQPG	ARC_HUMAN	Gene/Protein Processing	[14]
Acylamino-acid-releasing enzyme (APEH)	OTX258QE	ACPH_HUMAN	Gene/Protein Processing	[17]

References

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• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2585).
• [3] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [4] Atypical antipsychotics as noncompetitive inhibitors of alpha4beta2 and alpha7 neuronal nicotinic receptors. Neuropharmacology. 2009 Aug;57(2):183-91.
• [5] Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes. Arch Toxicol. 1999 Mar;73(2):65-70.
• [6] Effects of nicotine on cytochrome P450 2A6 and 2E1 activities. Br J Clin Pharmacol. 2010 Feb;69(2):152-9.
• [7] Liquid chromatography-tandem mass spectrometry method for measurement of nicotine N-glucuronide: a marker for human UGT2B10 inhibition. J Pharm Biomed Anal. 2011 Jul 15;55(5):964-71.
• [8] CYP2A6- and CYP2A13-catalyzed metabolism of the nicotine delta-5'(1')iminium ion. J Pharmacol Exp Ther. 2012 Nov;343(2):307-15.
• [9] Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-butanone metabolism by cytochrome P450 2B6. Drug Metab Dispos. 2005 Dec;33(12):1760-4.
• [10] Inactivation of CYP2A6 and CYP2A13 during nicotine metabolism. J Pharmacol Exp Ther. 2006 Jan;316(1):295-303.
• [11] Optimization of a nicotine degrading enzyme for potential use in treatment of nicotine addiction. BMC Biotechnol. 2019 Aug 2;19(1):56.
• [12] nAChRs-ERK1/2-Egr-1 signaling participates in the developmental toxicity of nicotine by epigenetically down-regulating placental 11beta-HSD2. Toxicol Appl Pharmacol. 2018 Apr 1;344:1-12.
• [13] Decreased levels of H3K9ac and H3K27ac in the promotor region of ovarian P450 aromatase mediated low estradiol synthesis in female offspring rats induced by prenatal nicotine exposure as well as in human granulosa cells after nicotine treatment. Food Chem Toxicol. 2019 Jun;128:256-266. doi: 10.1016/j.fct.2019.03.055. Epub 2019 Apr 6.
• [14] Characterizing the genetic basis for nicotine induced cancer development: a transcriptome sequencing study. PLoS One. 2013 Jun 18;8(6):e67252.
• [15] In vitro effects of aldehydes present in tobacco smoke on gene expression in human lung alveolar epithelial cells. Toxicol In Vitro. 2013 Apr;27(3):1072-81.
• [16] Nicotine treatment induces expression of matrix metalloproteinases in human osteoblastic Saos-2 cells. Acta Biochim Biophys Sin (Shanghai). 2006 Dec;38(12):874-82. doi: 10.1111/j.1745-7270.2006.00240.x.
• [17] Nicotinic modulation of gene expression in SH-SY5Y neuroblastoma cells. Brain Res. 2006 Oct 20;1116(1):39-49.
• [18] Functional versus chemical diversity: is biodiversity important for drug discovery. Trends Pharmacol Sci. 2002 May;23(5):225-31.
• [19] Pharmacological characteristics of the inhibition of nondepolarizing neuromuscular blocking agents at human adult muscle nicotinic acetylcholine receptor. Anesthesiology. 2009 Jun;110(6):1244-52.
• [20] Mecamylamine (Inversine): an old antihypertensive with new research directions. J Hum Hypertens. 2002 Jul;16(7):453-7.
• [21] The pipeline and future of drug development in schizophrenia. Mol Psychiatry. 2007 Oct;12(10):904-22.
• [22] EP patent application no. 2774991, Drug delivery system for use in the treatment or diagnosis of neurological disorders.
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