Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2L6OZ)

Drug Name

27-hydroxycholesterol Drug Info

Synonyms

27-OHC; 26-hydroxycholesterol

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 123976
ChEBI ID: CHEBI:76591
CAS Number: CAS 20380-11-4
TTD Drug ID: DM2L6OZ

Molecule-Related Drug Atlas

Molecule Type:

DTT

Drug Status:

Clinical Trial Drug(s)

Investigative Drug(s)

Patented Agent(s)

Download the Complete Related Drug List

Drug(s) Targeting Oxysterols receptor LXR-beta (NR1H2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
VTB-38543	DMNY3J0	Atopic dermatitis	EA80	Phase 2	[4]
2-Propanol, Isopropanol	DML5O0H	Discovery agent	N.A.	Investigative	[5]
Desmosterol	DMV8SUM	Discovery agent	N.A.	Investigative	[6]
L-783483	DM6OTGE	Discovery agent	N.A.	Investigative	[7]
WAY-214950	DM8ODI7	Discovery agent	N.A.	Investigative	[8]
22R-hydroxycholesterol	DME8273	Discovery agent	N.A.	Investigative	[9]
GSK-9772	DM4WS3R	Discovery agent	N.A.	Investigative	[10]
Riccardin C	DM6MYGX	Discovery agent	N.A.	Investigative	[11]
2-benzyl-4,5,6,7-tetrachloroisoindoline-1,3-dione	DMH76SO	Discovery agent	N.A.	Investigative	[12]
AZ12260493	DMQ5H2V	Discovery agent	N.A.	Investigative	[13]
------------------------------------------------------------------------------------


⏷ Show the Full List of 10 Drug(s)

Drug(s) Targeting Oxysterols receptor LXR-alpha (NR1H3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US9073931, E2	DMK9FJG	N. A.	N. A.	Patented	[14]
BDBM50177019	DMEL28G	N. A.	N. A.	Patented	[15]
US9006244, E2b	DMP0TBO	N. A.	N. A.	Patented	[16]
US9073931, E1	DM2Z43I	N. A.	N. A.	Patented	[14]
US9006244, E1	DMBF1C0	N. A.	N. A.	Patented	[16]
BDBM50177012	DM52IQF	N. A.	N. A.	Patented	[15]
US9006244, E2a	DMPDF9B	N. A.	N. A.	Patented	[16]
67S	DMJL1MB	N. A.	N. A.	Patented	[15]
US9073931, E3	DMCYM8P	N. A.	N. A.	Patented	[14]
Desmosterol	DMV8SUM	Discovery agent	N.A.	Investigative	[6]
------------------------------------------------------------------------------------


⏷ Show the Full List of 10 Drug(s)

Drug(s) Targeting EBV-induced G-protein coupled receptor 2 (GPR183)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
25-hydroxycholesterol	DMCHAQ7	Discovery agent	N.A.	Investigative	[2]
7alpha,25-dihydroxycholesterol	DM2N8TW	Discovery agent	N.A.	Investigative	[17]
7alpha,27-dihydroxycholesterol	DM52UOM	Discovery agent	N.A.	Investigative	[2]
7beta-hydroxycholesterol	DMPHJZU	Discovery agent	N.A.	Investigative	[2]
7beta, 27-dihydroxycholesterol	DMSDINR	Discovery agent	N.A.	Investigative	[2]
7alpha-hydroxycholesterol	DMH6LD0	Discovery agent	N.A.	Investigative	[2]
7beta, 25-dihydroxycholesterol	DMYKXWE	Discovery agent	N.A.	Investigative	[2]
------------------------------------------------------------------------------------


⏷ Show the Full List of 7 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
EBV-induced G-protein coupled receptor 2 (GPR183)	TTME5YJ	GP183_HUMAN	Agonist	[2]
Oxysterols receptor LXR-alpha (NR1H3)	TTECBXN	NR1H3_HUMAN	Agonist	[3]
Oxysterols receptor LXR-beta (NR1H2)	TTXA6PH	NR1H2_HUMAN	Agonist	[3]

------------------------------------------------------------------------------------

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2752).
2	Oxysterols direct B-cell migration through EBI2. Nature. 2011 Jul 27;475(7357):519-23.
3	27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells. J Biol Chem. 2001 Oct 19;276(42):38378-87.
4	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5	How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
6	Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands. J Biol Chem. 2006 Sep 22;281(38):27816-26.
7	A novel liver X receptor agonist establishes species differences in the regulation of cholesterol 7alpha-hydroxylase (CYP7a). Endocrinology. 2002 Jul;143(7):2548-58.
8	Indazole-based liver X receptor (LXR) modulators with maintained atherosclerotic lesion reduction activity but diminished stimulation of hepatic tr... J Med Chem. 2008 Nov 27;51(22):7161-8.
9	An oxysterol signalling pathway mediated by the nuclear receptor LXR alpha. Nature. 1996 Oct 24;383(6602):728-31.
10	Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity. J Med Chem. 2008 Sep 25;51(18):5758-65.
11	Co-existence of alpha-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development. Bioorg Med Chem. 2008 Apr 15;16(8):4272-85.
12	Liver X receptor antagonists with a phthalimide skeleton derived from thalidomide-related glucosidase inhibitors. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3957-61.
13	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 601).
14	Liver X receptor modulators. US9073931.
15	Piperazine derivatives as liver X receptor modulators. US10144715.
16	Liver X receptor modulators. US9006244.
17	Oxysterols direct immune cell migration via EBI2. Nature. 2011 Jul 27;475(7357):524-7.