Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2L6OZ)

• Drug Name: 27-hydroxycholesterol Drug Info
• Synonyms: 27-OHC; 26-hydroxycholesterol

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 123976
  ChEBI ID: CHEBI:76591
  CAS Number: CAS 20380-11-4
  TTD Drug ID: DM2L6OZ

Molecule-Related Drug Atlas

Drug(s) Targeting Oxysterols receptor LXR-beta (NR1H2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
VTB-38543	DMNY3J0	Atopic dermatitis	EA80	Phase 2	[13]
2-Propanol, Isopropanol	DML5O0H	Discovery agent	N.A.	Investigative	[14]
desmosterol	DMV8SUM	Discovery agent	N.A.	Investigative	[15]
L-783483	DM6OTGE	Discovery agent	N.A.	Investigative	[16]
WAY-214950	DM8ODI7	Discovery agent	N.A.	Investigative	[17]
22R-hydroxycholesterol	DME8273	Discovery agent	N.A.	Investigative	[18]
GSK-9772	DM4WS3R	Discovery agent	N.A.	Investigative	[19]
Riccardin C	DM6MYGX	Discovery agent	N.A.	Investigative	[20]
2-benzyl-4,5,6,7-tetrachloroisoindoline-1,3-dione	DMH76SO	Discovery agent	N.A.	Investigative	[21]
AZ12260493	DMQ5H2V	Discovery agent	N.A.	Investigative	[22]

Drug(s) Targeting Oxysterols receptor LXR-alpha (NR1H3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
US9073931, E2	DMK9FJG	N. A.	N. A.	Patented	[23]
BDBM50177019	DMEL28G	N. A.	N. A.	Patented	[24]
US9006244, E2b	DMP0TBO	N. A.	N. A.	Patented	[25]
US9073931, E1	DM2Z43I	N. A.	N. A.	Patented	[23]
US9006244, E1	DMBF1C0	N. A.	N. A.	Patented	[25]
BDBM50177012	DM52IQF	N. A.	N. A.	Patented	[24]
US9006244, E2a	DMPDF9B	N. A.	N. A.	Patented	[25]
67S	DMJL1MB	N. A.	N. A.	Patented	[24]
US9073931, E3	DMCYM8P	N. A.	N. A.	Patented	[23]
desmosterol	DMV8SUM	Discovery agent	N.A.	Investigative	[15]

Drug(s) Targeting EBV-induced G-protein coupled receptor 2 (GPR183)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
25-hydroxycholesterol	DMCHAQ7	Discovery agent	N.A.	Investigative	[2]
7alpha,25-dihydroxycholesterol	DM2N8TW	Discovery agent	N.A.	Investigative	[26]
7alpha,27-dihydroxycholesterol	DM52UOM	Discovery agent	N.A.	Investigative	[2]
7beta-hydroxycholesterol	DMPHJZU	Discovery agent	N.A.	Investigative	[2]
7beta, 27-dihydroxycholesterol	DMSDINR	Discovery agent	N.A.	Investigative	[2]
7alpha-hydroxycholesterol	DMH6LD0	Discovery agent	N.A.	Investigative	[2]
7beta, 25-dihydroxycholesterol	DMYKXWE	Discovery agent	N.A.	Investigative	[2]

Drug(s) Affected By 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[27]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[28]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[29]
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[30]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[31]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[32]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[34]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[35]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[36]

Drug(s) Affected By ATP-binding cassette sub-family G member 1 (ABCG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[37]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[35]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[39]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[40]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[41]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[41]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[43]

Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[44]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[44]
Ergonovine	DM0VEC1	Postpartum haemorrhage	JA43	Approved	[30]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[45]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[46]
Mizolastine	DM1FDN8	Allergic rhinitis	CA08.0	Approved	[47]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[48]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[49]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[50]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[51]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[52]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[53]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[54]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[55]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[56]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[57]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[58]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[60]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[58]

Drug(s) Affected By E-selectin (SELE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[61]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[63]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[64]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[65]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[67]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[68]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[69]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[70]

Drug(s) Affected By Liver carboxylesterase 1 (CES1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[71]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[72]
Dextropropoxyphene	DM23HCX	Pain	MG30-MG3Z	Approved	[73]
Selenium	DM25CGV	N. A.	N. A.	Approved	[74]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[75]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[77]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[78]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[79]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[80]

Drug(s) Affected By Toll-like receptor 4 (TLR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[81]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[82]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[83]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[40]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[84]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[85]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[82]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[41]

Drug(s) Affected By Prostaglandin E synthase (PTGES)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[87]
Selenium	DM25CGV	N. A.	N. A.	Approved	[74]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[88]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[89]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[90]
Mestranol	DMG3F94	Contraception	QA21	Approved	[87]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[91]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]

Drug(s) Affected By Integrin beta-1 (ITGB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[93]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[94]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[95]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[97]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[98]
Fructose	DM43AN2	Vomiting	MD90	Approved	[99]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[101]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[102]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[103]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[104]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[105]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[106]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[107]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[108]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[51]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[81]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[109]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[111]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[104]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[112]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[106]
Selenium	DM25CGV	N. A.	N. A.	Approved	[113]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[114]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[115]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[116]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[117]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[118]

Drug(s) Affected By Platelet glycoprotein 4 (CD36)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[119]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[121]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[122]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[124]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[126]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[127]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[128]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[129]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[130]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[131]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[132]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[133]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[134]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[104]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[58]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[135]

Drug(s) Affected By Sphingomyelin phosphodiesterase 2 (SMPD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[136]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[137]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[138]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[139]
Nicotinamide-Adenine-Dinucleotide	DM9LRKB	N. A.	N. A.	Investigative	[140]

Drug(s) Affected By CCN family member 5 (CCN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[104]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[141]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[142]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[142]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[142]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[144]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[145]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[146]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[147]

Drug(s) Affected By Phospholipid-transporting ATPase ABCA1 (ABCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[148]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[34]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[35]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[149]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[150]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[151]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[152]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[153]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[154]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[155]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[156]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[157]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[158]
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[160]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[161]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[162]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[81]

Drug(s) Affected By Low-density lipoprotein receptor (LDLR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[163]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[31]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[163]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[164]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[28]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[35]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[166]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[167]

Drug(s) Affected By Estrogen receptor (ESR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[168]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[169]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[170]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[172]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[173]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[174]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[175]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[171]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[176]

Drug(s) Affected By Trefoil factor 1 (TFF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[177]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[178]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[179]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[180]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[181]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[182]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[179]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[183]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[184]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[185]

Drug(s) Affected By Amyloid-beta precursor protein (APP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Selenium	DM25CGV	N. A.	N. A.	Approved	[74]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[81]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[186]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[141]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[187]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[189]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[190]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[191]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[142]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[192]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[55]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[103]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[57]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[106]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[194]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[195]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[142]

Drug(s) Affected By Progesterone receptor (PGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[196]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[197]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[198]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[199]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[200]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[201]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[185]
Goserelin	DMAT8CG	Breast cancer	2C60-2C65	Approved	[202]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[204]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[205]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[206]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[207]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[208]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[209]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[210]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[211]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[212]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[210]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[213]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[214]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[55]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[215]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[57]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[216]
Selenium	DM25CGV	N. A.	N. A.	Approved	[217]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[51]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[218]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[219]

Drug(s) Affected By C-C motif chemokine 3 (CCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[103]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[220]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[221]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[223]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[224]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[225]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[225]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[103]

Drug(s) Affected By C-C motif chemokine 4 (CCL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[220]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[221]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[226]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[224]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[227]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[225]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[228]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[225]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[229]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[41]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[230]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[231]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[232]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[233]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[234]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[235]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[236]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[237]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[238]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[239]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[240]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[241]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[242]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[243]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[244]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[245]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[246]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[247]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[248]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[239]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[249]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[250]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[251]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[238]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[30]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[93]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[241]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[242]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[252]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[253]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[254]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[255]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[256]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[257]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[258]
Selenium	DM25CGV	N. A.	N. A.	Approved	[74]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[32]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[160]

Drug(s) Affected By Cadherin-5 (CDH5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[259]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[66]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[260]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[261]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[262]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[263]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[264]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[265]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[266]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[267]

Drug(s) Affected By Multidrug resistance-associated protein 1 (ABCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[268]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[269]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[271]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[272]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[273]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[274]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[275]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[276]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[276]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[277]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[278]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[279]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[280]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[281]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[282]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[283]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[284]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[285]

Drug(s) Affected By Alpha-synuclein (SNCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[190]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[286]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[287]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[288]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[91]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Bortezomib	DMNO38U	Leukemia		Approved	[289]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[290]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[291]

Drug(s) Affected By Stress-70 protein, mitochondrial (HSPA9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[167]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[292]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[293]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[294]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[295]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[296]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[297]

Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[30]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[93]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[133]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[298]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[299]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[300]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[301]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[302]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[303]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[304]

Drug(s) Affected By Stromal cell-derived factor 1 (CXCL12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[94]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[87]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[305]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[167]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[262]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[87]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[306]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[228]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[307]

Drug(s) Affected By Steroidogenic acute regulatory protein, mitochondrial (STAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[308]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[190]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[309]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[124]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[310]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[311]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[312]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[313]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[314]

Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[315]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[316]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[317]
Selenium	DM25CGV	N. A.	N. A.	Approved	[74]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[318]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[319]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[320]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[321]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[322]

Drug(s) Affected By Cadherin-6 (CDH6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[323]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[228]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[91]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[92]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[324]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[325]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[326]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[265]

Drug(s) Affected By Beta-secretase 1 (BACE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[315]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[216]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[328]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[40]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[329]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[292]

Drug(s) Affected By Actin, aortic smooth muscle (ACTA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[331]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[332]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[76]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[333]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[334]
Pirfenidone	DM6VZFQ	Idiopathic pulmonary fibrosis	CB03.4	Approved	[335]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[40]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[336]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[337]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[336]

Drug(s) Affected By Transcription factor E2F1 (E2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[338]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[339]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[340]
Selenium	DM25CGV	N. A.	N. A.	Approved	[74]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[341]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[342]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[98]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[141]

Drug(s) Affected By Steroidogenic factor 1 (NR5A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[343]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[344]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[345]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[346]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[347]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[348]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[138]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[349]
Forskolin	DM6ITNG	Solid tumour/cancer	2A00-2F9Z	Investigative	[350]

Drug(s) Affected By Receptor tyrosine-protein kinase erbB-4 (ERBB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[351]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[352]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[353]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[262]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[354]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[355]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[296]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[356]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[357]

Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[358]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[359]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[360]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[360]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[361]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[362]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[363]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[279]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[34]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[364]

Drug(s) Affected By Sterol 26-hydroxylase, mitochondrial (CYP27A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[365]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[148]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[35]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[366]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[8]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[352]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[184]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[42]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[367]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[368]

Drug(s) Affected By Cytochrome P450 7A1 (CYP7A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[369]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[365]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[301]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[370]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[371]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[220]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[372]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[373]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[374]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[370]

Drug(s) Affected By Cytochrome P450 7B1 (CYP7B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[375]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[376]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[184]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[143]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[377]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[378]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[379]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[377]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[380]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[381]

Drug(s) Affected By Phosphatidylcholine-sterol acyltransferase (LCAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[33]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[35]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[382]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[86]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[383]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[296]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[291]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[291]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
EBV-induced G-protein coupled receptor 2 (GPR183)	TTME5YJ	GP183_HUMAN	Agonist	[2]
Oxysterols receptor LXR-alpha (NR1H3)	TTECBXN	NR1H3_HUMAN	Agonist	[3]
Oxysterols receptor LXR-beta (NR1H2)	TTXA6PH	NR1H2_HUMAN	Agonist	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)	OTRT3F3U	HMDH_HUMAN	Gene/Protein Processing	[4]
Actin, aortic smooth muscle (ACTA2)	OTEDLG8E	ACTA_HUMAN	Gene/Protein Processing	[5]
Alpha-synuclein (SNCA)	OTPWC1MR	SYUA_HUMAN	Gene/Protein Processing	[6]
Amyloid-beta precursor protein (APP)	OTKFD7R4	A4_HUMAN	Protein Interaction/Cellular Processes	[7]
ATP-binding cassette sub-family G member 1 (ABCG1)	OT5BG6MK	ABCG1_HUMAN	Gene/Protein Processing	[8]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Gene/Protein Processing	[9]
Beta-secretase 1 (BACE1)	OTCA7B6A	BACE1_HUMAN	Gene/Protein Processing	[10]
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Gene/Protein Processing	[11]
C-C motif chemokine 3 (CCL3)	OTW2H3ND	CCL3_HUMAN	Gene/Protein Processing	[12]
C-C motif chemokine 4 (CCL4)	OT6B8P25	CCL4_HUMAN	Gene/Protein Processing	[12]

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