Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMVDTR2)

• Drug Name: Thymoquinone Drug Info
• Synonyms: 490-91-5; Thymoquinon; p-Cymene-2,5-dione; 2-Isopropyl-5-methyl-1,4-benzoquinone; 2,5-CYCLOHEXADIENE-1,4-DIONE, 2-METHYL-5-(1-METHYLETHYL)-; 2-Isopropyl-5-methyl-p-benzoquinone; 2-Isopropyl-5-methylbenzoquinone; Polythymoquinone; 5-Isopropyl-2-methyl-1,4-benzoquinone; 2-Isopropyl-5-methylbenzo-1,4-quinone; p-Mentha-3,6-diene-2,5-dione; NSC 2228; 2-Isopropyl-5-methylcyclohexa-2,5-diene-1,4-dione; 2-Methyl-5-isopropyl-p-benzoquinone; 2-methyl-5-propan-2-ylcyclohexa-2,5-diene-1,4-dione; NSC2228; 2-methyl-5-(propan-2-yl)cyclohexa-2,5-diene-1,4-dione; UNII-O60IE26NUF; 2-Methyl-5-isopropyl-1,4-benzoquinone; O60IE26NUF; 2,5-Cyclohexadiene-1,4-dione, 5-isopropyl-2-methyl-; NSC-2228; 5-Isopropyl-2-methyl-p-benzoquinone; MFCD00001602; 2-Methyl-5-(1-methylethyl)-2,5-cyclohexadiene-1,4-dione; p-Mentha-3,6-diene-2,5-dione (8CI); 5-Isopropyl-2-methyl-2,5-Cyclohexadiene-1,4-dione; CCRIS 7152; EINECS 207-721-1; 2-methyl-5-(methylethyl)cyclohexa-2,5-diene-1,4-dione; BRN 1939047; thymolquinone; Thymoil; AI3-17758; 4hco; p-Mentha-3,5-dione; Spectrum_001237; SpecPlus_000457; Thymoquinone, >=98%; Spectrum2_000700; Spectrum3_001345; Spectrum4_001895; Spectrum5_000550; BSPBio_003129; KBioGR_002455; KBioSS_001717; DivK1c_006553; SCHEMBL542535; SPBio_000859; CHEMBL1672002; DTXSID9060079; KBio1_001497; KBio2_001717; KBio2_004285; KBio2_006853; KBio3_002349; Thymoquinone, analytical standard; CHEBI:113532; 2-Methyl-5-iso-propylbenzoquinone; BDBM166686; ZINC164367; BCP16946; HY-D0803; WLN: L6V DVJ B1 EY1&1; 2,4-dione, 5-isopropyl-2-methyl-; ANW-41600; CCG-40027; s4761; SBB008296; AKOS003368628; MCULE-9899033250; NCGC00178250-01; NCGC00178250-05; 73940-92-8; AK101679; AS-11327; 2-Isopropyl-5-methylbenzo-1,4-quinone #; 2,4-dione, 2-methyl-5-(1-methylethyl)-; CS-0012226; FT-0612708; ST45023960; K-9199; SR-05000002192; Q7799650; SR-05000002192-2; W-202869; BRD-K97566842-001-03-5; Thymoquinone; 2-isopropyl-5-methylbenzo-1,4-quinone; 2-methyl-5-(propan-2-yl)cyclohexa-2,5-diene-1,4-dione (F8); 2-Methyl-5-(1-methylethyl)-2,5-cyclohexadiene-1,4-dione, 9CI

Indication

Disease Entry	ICD 11	Status	REF
Polycystic ovarian syndrome	5A80.1	Phase 2/3	[1]

• Cross-matching ID:
  PubChem CID: 10281
  ChEBI ID: CHEBI:113532
  CAS Number: CAS 490-91-5
  TTD Drug ID: DMVDTR2

Molecule-Related Drug Atlas

Drug(s) Targeting Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Contusugene ladenovec	DMN9ETB	Oral cancer	2B6E	Phase 3	[8]
QPI-1002	DMDU5Y2	Renal transplantation	NE84	Phase 3	[9]
APG-115	DMIFA0L	Prolymphocytic leukaemia	2A82.1	Phase 2	[10]
SGT-53	DMLYIPA	Pancreatic cancer	2C10	Phase 2	[11]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[12]
Ad-p53	DMJSWXL	Solid tumour/cancer	2A00-2F9Z	Phase 2	[13]
Kevetrin	DMFO6MH	Ovarian cancer	2C73	Phase 2	[10]
INGN-225	DMF7J6D	Head and neck cancer	2D42	Phase 2	[14]
ALT-801	DM9KL7P	Acute myeloid leukaemia	2A60	Phase 2	[15]
ISA-P53-01	DMQ5EYJ	Colorectal cancer	2B91.Z	Phase 1/2	[16]

Drug(s) Targeting Apoptosis regulator Bcl-2 (BCL-2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MCI-186	DM8ZHP1	Amyotrophic lateral sclerosis	8B60.0	Approved	[17]
Taxol	DMUOT9V	Breast cancer	2C60-2C65	Approved	[18]
GDC-0199	DMH0QKA	Chronic lymphocytic leukaemia	2A82.0	Approved	[19]
ABT-263	DMNE56X	Myelofibrosis	2A20.2	Phase 3	[20]
Taxol/Paraplatin/Herceptin	DML6GAN	Breast cancer	2C60-2C65	Phase 3	[21]
Oblimersen	DM7KI4E	Melanoma	2C30	Phase 3	[22]
RG7601	DMDVAFP	Chronic lymphocytic leukaemia	2A82.0	Phase 3	[19]
Obatoclax	DMPF9ZM	Solid tumour/cancer	2A00-2F9Z	Phase 2	[23]
PI-88/Taxotere	DM4FIWC	Solid tumour/cancer	2A00-2F9Z	Phase 2	[24]
Gossypol	DMJWE3I	Prostate cancer	2C82.0	Phase 2	[25]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[26]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[27]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[29]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[30]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[31]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[32]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[33]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[35]

Drug(s) Affected By Zinc finger protein SNAI2 (SNAI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[36]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[37]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[41]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]

Drug(s) Affected By Tyrosine-protein kinase JAK2 (JAK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Momelotinib	DMF98Q0	Myelofibrosis	2A20.2	Approved	[45]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[46]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[47]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[49]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[50]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[53]

Drug(s) Affected By Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[54]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[55]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[56]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[58]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[60]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[61]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[57]

Drug(s) Affected By Ubiquitin-like protein ATG12 (ATG12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[66]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[67]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[68]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[70]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[71]

Drug(s) Affected By Ubiquitin-like modifier-activating enzyme ATG7 (ATG7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[72]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[49]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[75]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[74]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[77]

Drug(s) Affected By Apoptosis-inducing factor 1, mitochondrial (AIFM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[78]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[29]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[82]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[83]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[84]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[85]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]

Drug(s) Affected By Zinc finger protein SNAI1 (SNAI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[86]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[36]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[87]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[88]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[89]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[90]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[91]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[92]

Drug(s) Affected By Metalloproteinase inhibitor 1 (TIMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pentoxifylline	DMU3DNC	Alcoholic hepatitis	DB94.1	Approved	[93]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[94]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[95]
Selenium	DM25CGV	N. A.	N. A.	Approved	[96]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[97]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[100]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[101]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[102]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[55]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[103]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[104]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Selenium	DM25CGV	N. A.	N. A.	Approved	[106]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[107]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[108]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[109]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]

Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Selenium	DM25CGV	N. A.	N. A.	Approved	[96]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[112]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[82]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[100]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[101]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[116]

Drug(s) Affected By Hepatocyte growth factor receptor (MET)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cabozantinib	DMIYDT4	Medullary thyroid gland carcinoma		Approved	[117]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[118]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[119]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[119]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[119]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[120]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[119]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[120]

Drug(s) Affected By Matrilysin (MMP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[64]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[122]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[124]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[128]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[129]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[130]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[131]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[132]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[133]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[134]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[135]
Selenium	DM25CGV	N. A.	N. A.	Approved	[136]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[137]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[138]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[64]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[139]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[140]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[29]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[142]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[143]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[142]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[144]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[145]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[146]

Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[147]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[57]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[148]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[149]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[150]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[151]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[152]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[153]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[154]

Drug(s) Affected By DNA topoisomerase 2-alpha (TOP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[155]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[157]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[158]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[159]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[161]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[163]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[36]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[164]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[165]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[166]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[168]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[39]

Drug(s) Affected By Proto-oncogene tyrosine-protein kinase Src (SRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosutinib	DMTI8YE	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[169]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[170]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[171]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[172]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[173]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[174]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[126]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[175]

Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[176]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[177]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[157]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[178]
Selenium	DM25CGV	N. A.	N. A.	Approved	[106]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[30]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[143]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[179]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[31]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[159]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[180]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[86]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[181]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[182]
Selenium	DM25CGV	N. A.	N. A.	Approved	[96]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[183]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[144]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[184]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[185]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[186]

Drug(s) Affected By Metalloproteinase inhibitor 2 (TIMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[178]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[187]
Selenium	DM25CGV	N. A.	N. A.	Approved	[96]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[188]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[189]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[100]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[190]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[191]
Tetracaine	DM9J6C2	Spinal anesthesia	MB40.3	Approved	[192]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]

Drug(s) Affected By CD44 antigen (CD44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[46]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[178]
Selenium	DM25CGV	N. A.	N. A.	Approved	[194]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[37]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[195]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[99]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[196]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[39]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[197]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[198]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[199]
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[200]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[201]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[203]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[204]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[205]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[55]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[206]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[207]
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[31]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[60]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[61]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[74]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[208]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[209]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[60]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[210]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[74]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[211]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[67]

Drug(s) Affected By Cadherin-2 (CDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[207]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[212]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[213]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[214]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[215]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[216]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[217]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[218]

Drug(s) Affected By Hepatocyte nuclear factor 1-alpha (HNF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[175]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[220]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[221]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[222]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[223]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[224]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[225]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[226]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[221]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[227]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[228]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[229]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[230]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[231]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[232]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[233]
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[107]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[234]

Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[176]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[177]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[235]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[236]
Selenium	DM25CGV	N. A.	N. A.	Approved	[106]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[143]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[237]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[184]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[238]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[239]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[240]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[241]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[242]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[243]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[244]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[245]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[93]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[246]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[247]

Drug(s) Affected By G1/S-specific cyclin-D2 (CCND2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[79]
Selenium	DM25CGV	N. A.	N. A.	Approved	[106]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[64]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[239]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[248]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[249]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[250]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[251]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]

Drug(s) Affected By G1/S-specific cyclin-D3 (CCND3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[176]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[231]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[239]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[252]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[253]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[249]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[254]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[172]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[255]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[256]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[257]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[258]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[259]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[229]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[260]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[261]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[262]
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[263]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[107]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[264]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[207]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[265]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[266]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[267]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[268]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[269]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[217]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[270]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[131]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[271]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[55]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[206]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[57]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[272]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[150]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[273]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[159]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[274]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[275]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[276]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[277]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[38]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[278]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[279]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[280]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[281]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[282]

Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[93]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[283]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[284]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[285]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[286]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[287]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[288]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[289]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[171]

Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[290]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[291]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[292]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[72]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[293]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[107]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[294]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[295]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[51]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[67]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[296]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[297]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[298]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[299]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[300]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[301]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[302]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[303]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[304]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[305]

Drug(s) Affected By Proliferation marker protein Ki-67 (MKI67)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[306]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[159]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[307]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[161]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[123]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[308]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[254]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[309]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[215]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[256]

Drug(s) Affected By Nestin (NES)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[310]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[311]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[213]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[312]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[313]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[314]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[175]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[315]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[316]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[317]

Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[147]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[318]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[319]
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[320]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[321]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[322]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[323]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[49]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[61]

Drug(s) Affected By Caspase-7 (CASP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[180]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[55]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[324]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[325]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[326]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[326]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[64]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[327]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[328]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[160]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[329]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[330]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[139]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[331]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[332]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[333]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[29]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[334]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[335]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[336]

Drug(s) Affected By BH3-interacting domain death agonist (BID)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[29]
Selenium	DM25CGV	N. A.	N. A.	Approved	[337]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[322]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[59]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[338]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[339]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[340]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]

Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[49]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[341]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[52]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[342]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[343]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[344]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[345]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[346]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[347]

Drug(s) Affected By Cytochrome c (CYCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[348]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[140]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[332]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[148]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[325]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[349]
Pefloxacin	DM49IGF	Gonococcal urethritis	1A70.0Y	Approved	[350]

Drug(s) Affected By E3 ubiquitin-protein ligase Mdm2 (MDM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Flucytosine	DM13VTW	Cryptococcal meningitis		Approved	[351]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[351]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[352]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[64]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[353]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[48]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[354]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[355]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[356]

Drug(s) Affected By POU domain, class 5, transcription factor 1 (POU5F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[178]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[311]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[357]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[39]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[197]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[358]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[359]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[360]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[361]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[259]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[362]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[29]
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[363]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[64]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[351]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[364]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[322]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[365]

Drug(s) Affected By Inactive caspase-12 (CASP12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[366]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[367]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[368]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[369]
Methamphetamine	DMPM4SK	Anxiety		Approved	[370]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[371]
Tetrandrine	DMAOJBX	Sarcoma	2A60-2C35	Phase 1	[372]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[373]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[367]
3,7,3',4'-TETRAHYDROXYFLAVONE	DMES906	Discovery agent	N.A.	Investigative	[374]

Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[375]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[305]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[376]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[377]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[378]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[379]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[380]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[381]

Drug(s) Affected By Autophagy protein 5 (ATG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[382]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[65]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[66]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[383]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[76]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[384]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[313]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[385]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[386]

Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3A (MAP1LC3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[387]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[388]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[66]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[389]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[175]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[315]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[390]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[317]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[391]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[69]

Drug(s) Affected By Homeobox protein NANOG (NANOG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[392]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[37]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[311]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[357]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[39]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[197]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[358]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[359]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[393]

Drug(s) Affected By Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[54]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[55]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[57]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[178]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[57]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[394]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[60]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[61]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[208]

Drug(s) Affected By Lymphoid enhancer-binding factor 1 (LEF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[395]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[269]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[218]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[396]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[175]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[397]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[398]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[399]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[400]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[386]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[245]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[241]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[401]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[246]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[247]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[402]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[403]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[404]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[405]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[406]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Apoptosis regulator BAX (BAX)	TTQ57WJ	BAX_HUMAN	Inhibitor	[2]
Apoptosis regulator Bcl-2 (BCL-2)	TTJGNVC	BCL2_HUMAN	Inhibitor	[2]
Cellular tumor antigen p53 (TP53)	TT7SBF5	P53_HUMAN	Inhibitor	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[3]
Apoptosis-inducing factor 1, mitochondrial (AIFM1)	OTKPWB7Q	AIFM1_HUMAN	Gene/Protein Processing	[4]
Autophagy protein 5 (ATG5)	OT4T5SMS	ATG5_HUMAN	Gene/Protein Processing	[5]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Gene/Protein Processing	[6]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Gene/Protein Processing	[4]
Bcl2-associated agonist of cell death (BAD)	OT63ERYM	BAD_HUMAN	Gene/Protein Processing	[7]
BH3-interacting domain death agonist (BID)	OTOSHSHU	BID_HUMAN	Gene/Protein Processing	[5]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Gene/Protein Processing	[3]
Cadherin-2 (CDH2)	OTH0Y56P	CADH2_HUMAN	Gene/Protein Processing	[3]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Protein Interaction/Cellular Processes	[5]

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