Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNO38U)

• Drug Name: Bortezomib Drug Info
• Synonyms: 179324-69-7; Velcade; Bortezomib (PS-341); UNII-69G8BD63PP; N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE; MLN-341; [(1R)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid; [(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic acid; CHEMBL325041; 69G8BD63PP; Boronic acid,; DPBA; PROSCRIPT BORONIC ACID; LPD 341; LPD-341; VELCADE (TN); Velcade (TN); Pyz-Phe-boroLeu; Bortezomib(JAN/USAN/INN); Velcade, MG-341, PS-341, Bortezomib; N-[(1R)-1-(dihydroxyboranyl)-3-methylbutyl]-Nalpha-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide; Bortezomib (Proteasome inhibitor); Peptide boronate

Indication

Disease Entry	ICD 11	Status	REF
Leukemia		Approved	[1]
Lung cancer	2C25.0	Approved	[1]
Lymphoproliferative syndrome		Approved	[1]
MALT lymphoma		Approved	[1]
Mantle cell lymphoma	2A85.5	Approved	[2]
Minimally invasive lung adenocarcinoma		Approved	[1]
Multiple myeloma	2A83	Approved	[3]
Nodal marginal zone lymphoma	2A85.0	Approved	[1]
Plasma cell myeloma	2A83.1	Approved	[1]
Recurrent adult burkitt lymphoma	2A85.6	Approved	[1]
Non-hodgkin lymphoma	2B33.5	Phase 3	[3]
B-cell neoplasm		Investigative	[1]
Colon cancer	2B90.Z	Investigative	[1]
Gastric cancer	2B72	Investigative	[1]

• Therapeutic Class: Anticancer Agents
• Cross-matching ID:
  PubChem CID: 387447
  ChEBI ID: CHEBI:52717
  CAS Number: CAS 179324-69-7
  TTD Drug ID: DMNO38U
  VARIDT Drug ID: DR01331
  INTEDE Drug ID: DR0221

Molecule-Related Drug Atlas

Drug(s) Targeting Cationic trypsinogen (PRSS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MELAGATRAN	DM4W8RE	N. A.	N. A.	Phase 3	[12]
Ulinastatin	DMIQCFG	Premature labour	JB00	Phase 3	[13]
Alpha-1 antitrypsin	DM5EFXZ	Coagulation defect	3B10.0	Phase 2	[14]
Dermolastin	DM6WSU2	Atopic dermatitis	EA80	Discontinued in Phase 2	[15]
RWJ-56423	DM6BIHE	Asthma	CA23	Discontinued in Phase 1	[16]
Patamostat	DM6HBQJ	Hypotension	BA20-BA21	Terminated	[14]
BMY-44621	DM8R3N0	N. A.	N. A.	Terminated	[17]
Grassystatin a	DM1PWX2	Discovery agent	N.A.	Investigative	[18]
2-(2-Hydroxy-phenyl)-1H-indole-5-carboxamidine	DM3UMYD	Discovery agent	N.A.	Investigative	[19]
4-(4-Benzyloxy-3-methoxy-benzylamino)-benzamidine	DME3PUT	Discovery agent	N.A.	Investigative	[20]

Drug(s) Targeting Kallikrein-related peptidase (KLK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ecallantide	DMOF2C6	Retina venous occlusion	9B74.1	Approved	[21]
Cetraxate	DMSP4JX	Peptic ulcer	DA61	Approved	[22]
LM-030	DMSJOE3	Congenital ichthyosiform erythroderma	EC20.02	Phase 2	[23]
Benzoxazinone derivative 2	DM4FHTG	N. A.	N. A.	Patented	[24]
Benzyl amine derivative 1	DMOU84B	N. A.	N. A.	Patented	[24]
Benzyl amine derivative 2	DMFK7EL	N. A.	N. A.	Patented	[24]
Heteroaryl-carboxamide derivative 11	DM1CWU7	N. A.	N. A.	Patented	[24]

Drug(s) Targeting Proteasome (PS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
MLN9708	DMCMETN	Amyloidosis	5D00	Approved	[25]
Carfilzomib	DM48K0X	Multiple myeloma	2A83	Approved	[26]
Marizomib	DME9QGW	Glioblastoma of brain	2A00.00	Phase 3	[27]
Oprozomib	DM16RIC	Hodgkin lymphoma	2B30	Phase 2	[28]
Delanzomib	DMX4DQH	Multiple myeloma	2A83	Phase 2	[29]
GSK3494245	DMSMQGL	Visceral leishmaniasis	1F54.0	Phase 1	[30]
PS-519	DMI0WHC	Ischemia-reperfusion injury	DB98.B	Terminated	[31]
MG-101	DM3RUT8	Discovery agent	N.A.	Investigative	[32]

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[33]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[34]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[35]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[36]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[35]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[35]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[37]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[35]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[38]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[39]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[40]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[41]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[42]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[43]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[45]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[46]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[47]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[41]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[8]

Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[48]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[49]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[50]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[51]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[52]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[53]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[46]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[54]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[55]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[56]

Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[57]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[58]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[59]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[44]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[8]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[60]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[61]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[62]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[63]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[64]

Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[65]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[66]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[68]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[69]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[68]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[70]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[71]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]

Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[74]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[65]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[75]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[76]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[68]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[77]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[79]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[80]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[81]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[82]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[83]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[84]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[85]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[86]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[87]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[88]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[89]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[87]

Drug(s) Affected By Extended synaptotagmin-2 (ESYT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[96]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[99]

Drug(s) Affected By Alternative prion protein (PRNP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[107]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[108]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[108]

Drug(s) Affected By Serine/threonine-protein kinase Sgk1 (SGK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[109]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[111]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[112]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[115]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[109]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[116]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]

Drug(s) Affected By Cytosolic acyl coenzyme A thioester hydrolase (ACOT7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[118]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[121]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[122]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[123]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[124]

Drug(s) Affected By GTP-binding protein 1 (GTPBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[127]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[127]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]

Drug(s) Affected By Galectin-8 (LGALS8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[132]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[133]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[96]

Drug(s) Affected By 26S proteasome non-ATPase regulatory subunit 12 (PSMD12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[135]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[136]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[137]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]

Drug(s) Affected By Leukocyte-specific transcript 1 protein (LST1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[127]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[102]
Coprexa	DMA0WEK	Neurological disorder	6B60	Phase 3	[139]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[140]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[142]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[118]

Drug(s) Affected By Agrin (AGRN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[144]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[144]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[144]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[146]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[147]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[148]

Drug(s) Affected By Krev interaction trapped protein 1 (KRIT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[149]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[150]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[151]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[153]
taurine	DMVW7N3	Discovery agent	N.A.	Investigative	[154]

Drug(s) Affected By Beta-1,3-N-acetylglucosaminyltransferase manic fringe (MFNG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[137]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[155]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[156]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[157]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[155]

Drug(s) Affected By Pirin (PIR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[160]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[144]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[161]

Drug(s) Affected By Pyridoxal kinase (PDXK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[159]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[162]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]

Drug(s) Affected By Stearoyl-CoA desaturase (SCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[163]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[164]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[164]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[165]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[164]
Fructose	DM43AN2	Vomiting	MD90	Approved	[166]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[164]

Drug(s) Affected By Suppressor of cytokine signaling 3 (SOCS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[167]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[168]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[169]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Fedratinib	DM4ZBK6	Myelofibrosis	2A20.2	Approved	[170]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Pyrimethamine	DM5X7VY	Malaria	1F40-1F45	Approved	[170]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[165]

Drug(s) Affected By TRAF-type zinc finger domain-containing protein 1 (TRAFD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[144]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[144]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[144]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[144]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[123]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[144]

Drug(s) Affected By Cytoplasmic dynein 1 intermediate chain 1 (DYNC1I1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[171]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[172]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[173]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]

Drug(s) Affected By Chromodomain-helicase-DNA-binding protein 2 (CHD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[175]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[136]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[176]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[177]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[178]

Drug(s) Affected By Golgi SNAP receptor complex member 2 (GOSR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[179]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[180]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[133]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[177]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[181]

Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[182]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[183]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[184]
Isoflavone	DM7U58J	N. A.	N. A.	Phase 4	[185]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[186]

Drug(s) Affected By Apolipoprotein L1 (APOL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[187]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[188]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]

Drug(s) Affected By Interferon-inducible protein AIM2 (AIM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[190]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[184]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[140]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[91]

Drug(s) Affected By Myosin regulatory light chain 12B (MYL12B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[191]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[192]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[193]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[194]

Drug(s) Affected By Centrosomal protein of 290 kDa (CEP290)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[150]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[143]

Drug(s) Affected By Small ribosomal subunit protein uS12m (MRPS12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[196]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[124]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[105]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[91]

Drug(s) Affected By UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[96]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[199]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[200]

Drug(s) Affected By V-type proton ATPase subunit e 1 (ATP6V0E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[192]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[181]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[201]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[91]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[202]

Drug(s) Affected By ATP-binding cassette sub-family C member 4 (ABCC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[203]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[204]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[205]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[206]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[207]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[209]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[210]

Drug(s) Affected By Transcription factor MafG (MAFG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[211]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[207]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[212]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]

Drug(s) Affected By Interleukin-1 receptor-associated kinase-like 2 (IRAK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[213]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[214]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[104]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[215]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[216]

Drug(s) Affected By PHD finger protein 1 (PHF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[217]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[177]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[218]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[91]

Drug(s) Affected By Synaptogyrin-2 (SYNGR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[173]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[177]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[118]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[218]

Drug(s) Affected By Cytohesin-interacting protein (CYTIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[162]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[219]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[220]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[221]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[222]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[223]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[224]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[91]

Drug(s) Affected By Growth arrest-specific protein 7 (GAS7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[225]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[226]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[227]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[149]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[228]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[220]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]

Drug(s) Affected By F-box-like/WD repeat-containing protein TBL1X (TBL1X)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[146]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[229]

Drug(s) Affected By Glycosaminoglycan xylosylkinase (FAM20B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[91]

Drug(s) Affected By Suppressor of cytokine signaling 5 (SOCS5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[230]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[231]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Indomethacin	DMSC4A7	Bursitis		Approved	[232]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
AMEP	DMFELMQ	Melanoma	2C30	Phase 1	[233]

Drug(s) Affected By Protein tyrosine phosphatase type IVA 3 (PTP4A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[234]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[177]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[140]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]

Drug(s) Affected By Deformed epidermal autoregulatory factor 1 homolog (DEAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[235]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[236]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]

Drug(s) Affected By Calpain-15 (CAPN15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[155]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[155]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[237]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[140]

Drug(s) Affected By Carbonyl reductase 3 (CBR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[238]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[210]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[238]
Oxcarbazepine	DM5PU6O	Epilepsy	8A60-8A68	Approved	[239]
Acetohexamide	DMR6N7H	Diabetic complication	5A2Y	Approved	[240]

Drug(s) Affected By Triple functional domain protein (TRIO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[230]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[241]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[242]

Drug(s) Affected By Cystatin-F (CST7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[243]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[244]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[245]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[246]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[241]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[247]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[140]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[248]

Drug(s) Affected By ATP-dependent DNA helicase Q4 (RECQL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[214]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[249]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[250]

Drug(s) Affected By Erlin-2 (ERLIN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[210]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[123]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[251]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[252]

Drug(s) Affected By Pre-mRNA-processing factor 6 (PRPF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[168]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[122]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[201]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[177]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[143]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[99]

Drug(s) Affected By Lysine-specific demethylase 4B (KDM4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[253]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[168]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[229]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[254]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[177]

Drug(s) Affected By Methyl-CpG-binding domain protein 4 (MBD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[162]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]

Drug(s) Affected By Arginyl-tRNA--protein transferase 1 (ATE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[234]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[140]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[256]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]

Drug(s) Affected By GDH/6PGL endoplasmic bifunctional protein (H6PD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[257]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[258]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[259]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[259]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[123]

Drug(s) Affected By NAD kinase (NADK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[159]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[260]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[260]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[143]

Drug(s) Affected By AP-2 complex subunit alpha-1 (AP2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[99]
SB-431542	DM0YOXQ	Pulmonary fibrosis	CB03.4	Preclinical	[262]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[263]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[264]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[191]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[265]

Drug(s) Affected By Acyl-CoA 6-desaturase (FADS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[266]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[267]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[268]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[219]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[269]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[220]

Drug(s) Affected By Phosphatidylserine lipase ABHD16A (ABHD16A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[220]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[270]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[118]

Drug(s) Affected By G patch domain and ankyrin repeat-containing protein 1 (GPANK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[96]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[256]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By Putative lipid scramblase CLPTM1 (CLPTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[251]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[271]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[251]

Drug(s) Affected By Glutathione reductase, mitochondrial (GSR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[272]
Ketoprofen	DMRKXPT	Bursitis		Approved	[240]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[273]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[274]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[163]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[275]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[213]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[276]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[260]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[277]

Drug(s) Affected By HLA class II histocompatibility antigen, DR alpha chain (HLA-DRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[278]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[210]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[279]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[215]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[219]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[280]

Drug(s) Affected By Myelin basic protein (MBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[281]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[282]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[283]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[284]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[148]

Drug(s) Affected By Thy-1 membrane glycoprotein (THY1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[285]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[227]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[121]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[286]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[287]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[288]
Ximelegatran	DMU8ANS	Myocardial infarction	BA41-BA43	Approved	[289]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[172]

Drug(s) Affected By HLA class II histocompatibility antigen, DP beta 1 chain (HLA-DPB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[290]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[291]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[280]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[245]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[292]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[293]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[181]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[173]

Drug(s) Affected By T-cell surface glycoprotein CD5 (CD5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[294]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[295]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[296]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By Alpha-galactosidase A (GLA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[297]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[147]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]

Drug(s) Affected By HLA class II histocompatibility antigen, DO alpha chain (HLA-DOA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[298]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[210]
Saquinavir	DMG814N	Human immunodeficiency virus infection	1C62	Approved	[298]
Indapamide	DMGN1PW	Edema	MG29	Approved	[298]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[298]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[177]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[299]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[118]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[300]

Drug(s) Affected By Cathepsin D (CTSD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[301]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[302]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[303]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[304]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[305]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[306]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]

Drug(s) Affected By Trypsin-2 (PRSS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[307]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[308]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Vandetanib	DMRICNP	Solid tumour/cancer	2A00-2F9Z	Approved	[309]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[310]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[155]

Drug(s) Affected By Prosaposin (PSAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[311]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[311]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[312]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[199]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[124]

Drug(s) Affected By Guanine nucleotide-binding protein G(i) subunit alpha-3 (GNAI3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[135]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[313]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
SB-431542	DM0YOXQ	Pulmonary fibrosis	CB03.4	Preclinical	[262]

Drug(s) Affected By Steryl-sulfatase (STS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[315]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[315]
Tazarotene	DM8SMD1	Acne vulgaris	ED80	Approved	[316]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Danazol	DML8KTN	Menorrhagia	GA20.50	Approved	[317]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[316]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[315]

Drug(s) Affected By Monoacylglycerol lipase ABHD2 (ABHD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[109]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[109]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[162]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Mestranol	DMG3F94	Contraception	QA21	Approved	[109]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[109]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]

Drug(s) Affected By Gamma-enolase (ENO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[318]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[319]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[320]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[321]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[144]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]

Drug(s) Affected By Tropomyosin alpha-1 chain (TPM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[302]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[322]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[323]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[282]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[148]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[324]

Drug(s) Affected By Cancer/testis antigen family 45 member A6 (CT45A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[300]

Drug(s) Affected By Schwannomin-interacting protein 1 (SCHIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[325]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]

Drug(s) Affected By Granzyme B (GZMB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[326]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[327]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[328]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[192]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[329]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[330]
Ethambutol	DMR87LC	Pulmonary tuberculosis	1B10.Z	Approved	[328]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[331]
Pentoxifylline	DMU3DNC	Alcoholic hepatitis	DB94.1	Approved	[240]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[332]

Drug(s) Affected By Clusterin (CLU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[333]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[333]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[334]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[335]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[333]

Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[336]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[337]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[338]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[322]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[339]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[340]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[341]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[342]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[343]

Drug(s) Affected By Phenylethanolamine N-methyltransferase (PNMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[344]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[345]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[346]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[173]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[347]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[348]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[211]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[349]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[350]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[349]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[168]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[349]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[349]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[351]

Drug(s) Affected By Ras-related protein Ral-A (RALA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[167]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[352]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[207]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[147]

Drug(s) Affected By Breakpoint cluster region protein (BCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[353]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[354]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[355]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[149]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[356]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[150]

Drug(s) Affected By Glucose-6-phosphate 1-dehydrogenase (G6PD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[240]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[122]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[167]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[274]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[163]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[159]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[357]

Drug(s) Affected By Steroid hormone receptor ERR1 (ESRRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[358]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[359]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[360]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[361]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[362]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[363]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[363]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[364]
Isoflavone	DM7U58J	N. A.	N. A.	Phase 4	[365]

Drug(s) Affected By B-cell antigen receptor complex-associated protein alpha chain (CD79A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[364]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[366]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[367]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[91]
Rutin	DMEHRAJ	Discovery agent	N.A.	Investigative	[368]

Drug(s) Affected By Granzyme A (GZMA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[369]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[370]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[371]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[140]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[118]

Drug(s) Affected By Cytochrome b-245 light chain (CYBA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[372]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[373]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[374]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[375]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[162]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]

Drug(s) Affected By Sodium/potassium-transporting ATPase subunit alpha-3 (ATP1A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[376]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[364]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[102]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[377]

Drug(s) Affected By Perforin-1 (PRF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[326]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[162]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[329]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[176]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[173]
Pentoxifylline	DMU3DNC	Alcoholic hepatitis	DB94.1	Approved	[240]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[378]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[296]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By Insulin-degrading enzyme (IDE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[336]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[379]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[137]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]

Drug(s) Affected By Ras-related C3 botulinum toxin substrate 2 (RAC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[380]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[381]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[159]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[382]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[133]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]

Drug(s) Affected By Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[335]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[220]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[383]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]

Drug(s) Affected By Folate receptor alpha (FOLR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[384]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[219]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[385]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[241]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[386]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[387]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[388]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-2 (ATF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[264]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[230]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[168]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[389]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[390]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[391]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[123]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[144]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[392]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[211]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[393]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[394]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[395]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[396]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[397]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[398]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[165]

Drug(s) Affected By Immunoglobulin lambda-like polypeptide 1 (IGLL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[220]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[399]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[157]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[400]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[401]

Drug(s) Affected By Mucin-1 (MUC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[402]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[318]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[159]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[403]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[227]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[403]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[404]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[405]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[406]

Drug(s) Affected By Ribosyldihydronicotinamide dehydrogenase (NQO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[159]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[407]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[408]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[409]

Drug(s) Affected By Leukosialin (SPN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[173]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By Transcription factor JunD (JUND)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[410]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[264]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[411]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[196]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[260]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[207]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[160]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[412]

Drug(s) Affected By Integrin beta-6 (ITGB6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[286]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[413]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[414]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[151]

Drug(s) Affected By Ras-related protein Rab-5A (RAB5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[415]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[416]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[417]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[102]

Drug(s) Affected By Integrin alpha-L (ITGAL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[418]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[419]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[420]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[419]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[220]

Drug(s) Affected By B-cell lymphoma 3 protein (BCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[421]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[168]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[196]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[144]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[144]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[329]

Drug(s) Affected By 5'-nucleotidase (NT5E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[285]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[422]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[307]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[335]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[215]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]

Drug(s) Affected By Ephrin type-A receptor 1 (EPHA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[423]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[424]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[423]

Drug(s) Affected By CD9 antigen (CD9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[425]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[351]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]

Drug(s) Affected By Integrin alpha-6 (ITGA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[426]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[427]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[352]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[428]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[429]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[430]

Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[431]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[432]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[433]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[434]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[435]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[436]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[437]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[438]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[439]

Drug(s) Affected By Tyrosine-protein kinase JAK1 (JAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[230]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[440]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[441]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[132]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[219]

Drug(s) Affected By ER lumen protein-retaining receptor 1 (KDELR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[442]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[443]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[177]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[184]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[251]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[444]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[264]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[445]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[446]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[411]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[447]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[448]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[449]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[450]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[451]

Drug(s) Affected By Polypyrimidine tract-binding protein 1 (PTBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[168]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[162]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[220]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[452]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[201]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[129]

Drug(s) Affected By NKG2-D type II integral membrane protein (KLRK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[176]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[453]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[378]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[454]

Drug(s) Affected By CD82 antigen (CD82)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[285]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[455]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]

Drug(s) Affected By HLA class II histocompatibility antigen, DM beta chain (HLA-DMB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Topiramate	DM82Z30	Alcohol dependence	6C40.2	Approved	[298]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[227]
Valdecoxib	DMAY7H4	Osteoarthritis	FA00-FA05	Approved	[298]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[210]
Ethosuximide	DMDZ9LT	Epilepsy	8A60-8A68	Approved	[298]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[219]
Vancomycin	DM3JFIH	Bacteremia	1A73	Approved	[298]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[456]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[298]

Drug(s) Affected By ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[457]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[458]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[459]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[460]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[461]
Omacetaxine mepesuccinate	DMPU2WX	Adult acute monocytic leukemia		Approved	[458]
Novobiocin	DMRFWGK	Bacterial infection	1A00-1C4Z	Approved	[462]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[310]

Drug(s) Affected By Ephrin type-B receptor 2 (EPHB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[463]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[463]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[229]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[241]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[103]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]

Drug(s) Affected By Flavin reductase (BLVRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[211]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[464]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[278]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[194]

Drug(s) Affected By G1/S-specific cyclin-D2 (CCND2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[302]
Selenium	DM25CGV	N. A.	N. A.	Approved	[465]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[191]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[353]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[466]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[467]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[468]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[469]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]

Drug(s) Affected By Homeobox protein Hox-A11 (HOXA11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[168]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[141]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[470]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[143]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[118]

Drug(s) Affected By 14-3-3 protein sigma (SFN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[471]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[445]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[427]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[448]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[472]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[213]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[448]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[403]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[473]

Drug(s) Affected By Stress-induced-phosphoprotein 1 (STIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[474]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[475]
Haloperidol	DM96SE0	Delirium		Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[178]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[122]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[122]
Mecamylamine	DMGQFYB	Essential hypertension	BA00	Approved	[178]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[476]

Drug(s) Affected By Guanylate-binding protein 2 (GBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[464]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[179]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[162]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[219]

Drug(s) Affected By Multidrug resistance-associated protein 1 (ABCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[477]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[478]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[203]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[479]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[480]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[150]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[481]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[482]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[483]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[483]

Drug(s) Affected By Protein phosphatase 1A (PPM1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[162]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[484]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[103]

Drug(s) Affected By Transcription factor 7 (TCF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[258]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[485]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[133]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[245]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[486]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[181]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[487]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[488]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[489]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[490]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[136]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[491]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[207]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]

Drug(s) Affected By Transgelin-2 (TAGLN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[122]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Haloperidol	DM96SE0	Delirium		Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[323]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[122]

Drug(s) Affected By Pre-B-cell leukemia transcription factor 3 (PBX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[118]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[492]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[493]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]

Drug(s) Affected By Interleukin-15 (IL15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[471]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[494]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[282]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[495]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[413]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]

Drug(s) Affected By Trifunctional enzyme subunit alpha, mitochondrial (HADHA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[162]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[215]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[123]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[143]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[99]

Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 3 (EIF2S3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[496]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[122]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[122]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[102]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[256]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[142]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[91]

Drug(s) Affected By B-cell lymphoma 6 protein (BCL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[115]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[115]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[115]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[133]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[137]

Drug(s) Affected By Lysine-specific demethylase 5C (KDM5C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[497]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[498]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[256]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[129]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[282]

Drug(s) Affected By Eukaryotic translation initiation factor 1 (EIF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[499]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[192]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[144]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[283]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]

Drug(s) Affected By 5-hydroxytryptamine receptor 2B (HTR2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[240]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[500]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[244]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[501]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[383]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[242]
Fenfluramine	DM0762O	Dravet syndrome	8A61.11	Phase 3	[502]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[237]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By Lamina-associated polypeptide 2, isoform alpha (TMPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[503]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[504]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]

Drug(s) Affected By ETS translocation variant 4 (ETV4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[168]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[179]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[505]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[219]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[506]

Drug(s) Affected By Killer cell immunoglobulin-like receptor 2DS4 (KIR2DS4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[507]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[367]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[118]

Drug(s) Affected By 26S proteasome regulatory subunit 6B (PSMC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[474]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[429]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[124]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[508]

Drug(s) Affected By Lys-63-specific deubiquitinase BRCC36 (BRCC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[285]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[245]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[199]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[256]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]

Drug(s) Affected By LIM and senescent cell antigen-like-containing domain protein 1 (LIMS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[162]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[127]

Drug(s) Affected By NADP-dependent malic enzyme (ME1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[211]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[163]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[278]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[144]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[212]

Drug(s) Affected By MAP kinase-activated protein kinase 2 (MAPKAPK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[509]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[510]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[381]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[511]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[509]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[442]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[293]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[512]

Drug(s) Affected By Large ribosomal subunit protein bL19m (MRPL19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[230]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[124]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[513]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[514]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[91]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[515]

Drug(s) Affected By Beta-arrestin-1 (ARRB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[168]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[516]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[137]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[517]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]

Drug(s) Affected By Ubiquitin-conjugating enzyme E2 R1 (CDC34)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[416]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[184]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[184]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[518]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]

Drug(s) Affected By Choline-phosphate cytidylyltransferase A (PCYT1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[383]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[364]
G1	DMTV42K	Lymphoma	2A80-2A86	Phase 1/2	[519]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[256]

Drug(s) Affected By Protein phosphatase 1F (PPM1F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[122]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[234]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]
Nickel chloride	DMI12Y8	Discovery agent	N.A.	Investigative	[520]

Drug(s) Affected By Protein numb homolog (NUMB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[521]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[382]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[229]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[521]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]

Drug(s) Affected By Presenilin-1 (PSEN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[336]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[522]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[329]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[183]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[245]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[124]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]

Drug(s) Affected By Cytosolic purine 5'-nucleotidase (NT5C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[523]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[524]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[523]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[523]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[523]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]

Drug(s) Affected By DNA ligase 4 (LIG4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[415]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[525]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[178]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
Fenfluramine	DM0762O	Dravet syndrome	8A61.11	Phase 3	[526]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By Dynamin-2 (DNM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]
NS398	DMINUWH	Endometriosis	GA10	Terminated	[527]
Z-Pro-Prolinal	DM43O2U	Discovery agent	N.A.	Investigative	[528]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[529]

Drug(s) Affected By Poly(A) polymerase alpha (PAPOLA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[530]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[184]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[102]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By Tyrosine-protein kinase Blk (BLK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[329]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[364]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[531]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[325]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID25656651-Compound-5	DMAI95U	Chronic myeloid leukaemia	2A20	Patented	[354]
SB-431542	DM0YOXQ	Pulmonary fibrosis	CB03.4	Preclinical	[262]

Drug(s) Affected By Succinate-semialdehyde dehydrogenase, mitochondrial (ALDH5A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[260]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[260]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[241]

Drug(s) Affected By 26S proteasome non-ATPase regulatory subunit 7 (PSMD7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[381]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[429]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[532]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[122]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[122]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[533]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[534]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[535]

Drug(s) Affected By N-sulphoglucosamine sulphohydrolase (SGSH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[296]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[400]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[454]

Drug(s) Affected By AF4/FMR2 family member 1 (AFF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[220]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[536]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[537]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[538]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By Importin subunit alpha-1 (KPNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[503]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[302]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[539]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[496]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[540]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[541]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]

Drug(s) Affected By Diacylglycerol kinase epsilon (DGKE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[542]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[414]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[155]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[177]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[155]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[296]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[400]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[510]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[213]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[214]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[504]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[543]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[391]

Drug(s) Affected By Rho GDP-dissociation inhibitor 1 (ARHGDIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[322]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[319]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[544]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[306]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[113]

Drug(s) Affected By Cysteine-rich protein 2 (CRIP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[302]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[545]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[416]

Drug(s) Affected By Serine/threonine-protein phosphatase 5 (PPP5C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[122]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[546]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[428]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[547]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[233]

Drug(s) Affected By Delta-1-pyrroline-5-carboxylate synthase (ALDH18A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Haloperidol	DM96SE0	Delirium		Approved	[122]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[144]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[144]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[492]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]

Drug(s) Affected By Proteinase-activated receptor 2 (F2RL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[425]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[217]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]

Drug(s) Affected By Myc-associated zinc finger protein (MAZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[113]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[548]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[251]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[549]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[256]

Drug(s) Affected By ADP-ribosylation factor-like protein 4C (ARL4C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[278]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[227]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[532]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[404]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[219]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[150]
Indomethacin	DMSC4A7	Bursitis		Approved	[232]

Drug(s) Affected By Small integral membrane protein 11 (SMIM11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[245]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[113]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[103]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[550]

Drug(s) Affected By Triosephosphate isomerase (TPI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[322]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[551]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[552]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[193]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[553]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[323]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]

Drug(s) Affected By Cell division control protein 42 homolog (CDC42)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[412]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[415]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[554]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[555]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[556]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[272]

Drug(s) Affected By C-X-C chemokine receptor type 4 (CXCR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[557]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[315]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[558]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[559]
Carfilzomib	DM48K0X	Multiple myeloma	2A83	Approved	[560]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[315]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[561]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[420]

Drug(s) Affected By Large ribosomal subunit protein uL24 (RPL26)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[562]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[129]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[263]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[202]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[515]

Drug(s) Affected By cAMP-dependent protein kinase inhibitor alpha (PKIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[180]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[219]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[241]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[416]

Drug(s) Affected By AP-1 complex subunit sigma-1A (AP1S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[302]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[349]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[349]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[563]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[277]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[210]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[350]

Drug(s) Affected By Small ribosomal subunit protein uS17 (RPS11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[122]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[371]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[256]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[564]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[508]

Drug(s) Affected By ADP-ribosylation factor 6 (ARF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[565]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[123]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[566]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[383]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[416]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[302]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[168]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[219]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[556]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]

Drug(s) Affected By Calcineurin subunit B type 1 (PPP3R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[245]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[234]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[240]
Sirolimus	DMGW1ID	Advanced cancer	2A00-2F9Z	Approved	[240]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[240]
Tacrolimus	DMZ7XNQ	Graft-versus-host disease	4B24	Approved	[240]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PPP2R2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[123]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[265]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[234]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]

Drug(s) Affected By Small ubiquitin-related modifier 1 (SUMO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[381]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[567]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[411]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[568]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[155]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[399]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[256]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]

Drug(s) Affected By Eukaryotic translation initiation factor 5A-1 (EIF5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[322]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[135]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[235]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Morphine	DMRMS0L	Advanced cancer	2A00-2F9Z	Approved	[569]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[235]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[570]

Drug(s) Affected By DNA-dependent protein kinase catalytic subunit (PRKDC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[503]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[302]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[558]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[260]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[571]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[572]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]

Drug(s) Affected By Small ribosomal subunit protein uS5m (MRPS5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[573]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[124]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[177]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[99]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[508]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[574]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[575]

Drug(s) Affected By Spectrin beta chain, non-erythrocytic 1 (SPTBN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[135]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[576]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[329]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[148]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[245]

Drug(s) Affected By Large neutral amino acids transporter small subunit 1 (SLC7A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[109]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[428]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[577]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[159]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[403]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[109]

Drug(s) Affected By 2-oxoglutarate dehydrogenase complex component E1 (OGDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[118]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[578]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[428]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[162]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[576]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[122]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[124]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[547]

Drug(s) Affected By Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase , mitochondrial (ALDH6A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[230]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[260]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[297]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[260]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[579]

Drug(s) Affected By Mitochondrial 2-oxoglutarate/malate carrier protein (SLC25A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[577]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[159]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[124]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[240]

Drug(s) Affected By Glutathione S-transferase Mu 4 (GSTM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[557]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[335]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[580]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[177]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[581]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[184]

Drug(s) Affected By cAMP-responsive element modulator (CREM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[168]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[123]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[582]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[155]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[177]

Drug(s) Affected By Centromere protein C (CENPC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[383]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[256]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[285]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[583]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[584]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[585]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[586]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[587]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[588]

Drug(s) Affected By Neurogenic locus notch homolog protein 2 (NOTCH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[589]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[132]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[183]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[383]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[399]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[181]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[184]

Drug(s) Affected By CTD small phosphatase-like protein 2 (CTDSPL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[201]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 11 (PTPN11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[590]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[591]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[562]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[592]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Chondroitin sulfate	DM0N19Y	N. A.	N. A.	Phase 4	[593]

Drug(s) Affected By Early activation antigen CD69 (CD69)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[115]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[491]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[115]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[210]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[244]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[219]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[460]

Drug(s) Affected By Serine/arginine-rich splicing factor 1 (SRSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[503]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[149]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[594]

Drug(s) Affected By Rho GTPase-activating protein 1 (ARHGAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[168]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[135]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[123]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[220]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]

Drug(s) Affected By FACT complex subunit SSRP1 (SSRP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[176]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[177]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[181]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[595]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]

Drug(s) Affected By Sodium/bile acid cotransporter 7 (SLC10A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[417]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[248]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[153]

Drug(s) Affected By Apolipoprotein B receptor (APOBR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[383]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[140]

Drug(s) Affected By Nuclear factor 1 A-type (NFIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[504]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[231]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[493]

Drug(s) Affected By Interferon-related developmental regulator 2 (IFRD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[383]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[140]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[201]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[514]

Drug(s) Affected By Protein AF1q (MLLT11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[448]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[213]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[217]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[219]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[413]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]

Drug(s) Affected By PR domain zinc finger protein 2 (PRDM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[253]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[168]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[245]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[596]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[452]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]

Drug(s) Affected By Dual specificity protein phosphatase 4 (DUSP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[187]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[159]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[278]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]

Drug(s) Affected By Oxysterols receptor LXR-alpha (NR1H3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[428]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[576]
Gemfibrozil	DMD8Q3J	Hyperlipidaemia	5C80	Approved	[597]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[598]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[597]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[599]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[600]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[601]

Drug(s) Affected By Chromobox protein homolog 3 (CBX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[302]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[158]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[158]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]

Drug(s) Affected By Phosducin-like protein (PDCL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
EMODIN	DMAEDQG	Coronavirus Disease 2019 (COVID-19)	1D6Y	Terminated	[602]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[603]

Drug(s) Affected By DNA-binding protein Ikaros (IKZF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[227]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[293]
Vitamin C	DMXJ7O8	Adenocarcinoma	2D40	Approved	[604]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[102]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[91]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[515]

Drug(s) Affected By Protein OS-9 (OS9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[297]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[143]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[605]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[606]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[118]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[207]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[607]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[485]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[162]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[608]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[609]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[432]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[610]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[611]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[612]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[411]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[191]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[214]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[613]

Drug(s) Affected By Transformer-2 protein homolog alpha (TRA2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[122]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[160]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[614]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[162]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]

Drug(s) Affected By Rap guanine nucleotide exchange factor 1 (RAPGEF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[220]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[241]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[118]

Drug(s) Affected By High affinity 3',5'-cyclic-AMP phosphodiesterase 7A (PDE7A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Roflumilast	DMPGHY8	Asthma	CA23	Approved	[615]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
Trequinsin	DMQRSMD	N. A.	N. A.	Terminated	[615]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[118]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[103]

Drug(s) Affected By Nuclear transcription factor Y subunit gamma (NFYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[143]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[570]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[218]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[91]

Drug(s) Affected By Transcription factor Dp-1 (TFDP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[471]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[616]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[617]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[567]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[329]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[492]

Drug(s) Affected By Fas-activated serine/threonine kinase (FASTK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[158]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[162]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[149]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[329]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[158]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[618]

Drug(s) Affected By Mediator of DNA damage checkpoint protein 1 (MDC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[129]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[214]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]

Drug(s) Affected By Structural maintenance of chromosomes protein 1A (SMC1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[471]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[619]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[620]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[616]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[619]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[96]

Drug(s) Affected By Neutral alpha-glucosidase AB (GANAB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[302]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[148]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[508]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[508]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[302]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]

Drug(s) Affected By Kinesin-like protein KIF22 (KIF22)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[464]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[621]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[417]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[256]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]

Drug(s) Affected By DAZ-associated protein 2 (DAZAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[177]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[282]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[603]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[202]

Drug(s) Affected By Neutrophil cytosol factor 4 (NCF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[140]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[400]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[622]

Drug(s) Affected By kinase isozyme 2, mitochondrial (PDK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[352]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[498]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[124]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[383]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[237]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[140]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By Leucine-rich repeat-containing protein 41 (LRRC41)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[129]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[220]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[623]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[143]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[282]

Drug(s) Affected By Ras suppressor protein 1 (RSU1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[504]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[149]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[201]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[140]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[263]

Drug(s) Affected By Scaffold attachment factor B1 (SAFB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[118]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[122]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[167]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[99]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[256]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]

Drug(s) Affected By NF-kappa-B inhibitor beta (NFKBIB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[624]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[625]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[293]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
BAICALEIN	DM4C7E6	Influenza virus infection	1E30-1E32	Phase 2	[626]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[143]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[248]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]

Drug(s) Affected By NGFI-A-binding protein 2 (NAB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[167]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[160]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[627]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[148]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]

Drug(s) Affected By Neuronal pentraxin-1 (NPTX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[628]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[532]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[137]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[383]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]

Drug(s) Affected By Coiled-coil domain-containing protein 6 (CCDC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[230]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[220]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[629]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]

Drug(s) Affected By Drebrin (DBN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[382]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[630]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[123]

Drug(s) Affected By Solute carrier family 35 member G1 (SLC35G1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[504]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[180]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[241]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[383]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[296]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]

Drug(s) Affected By Protein mono-ADP-ribosyltransferase PARP6 (PARP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]

Drug(s) Affected By Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[118]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[217]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[415]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]

Drug(s) Affected By Polycomb group RING finger protein 3 (PCGF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[118]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[149]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[118]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[103]

Drug(s) Affected By NAD kinase 2, mitochondrial (NADK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[118]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[124]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[201]

Drug(s) Affected By B-cell CLL/lymphoma 7 protein family member A (BCL7A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[287]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[102]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[218]

Drug(s) Affected By Glycerol-3-phosphate acyltransferase 3 (GPAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[425]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[179]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[144]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[144]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[631]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[282]

Drug(s) Affected By Acylglycerol kinase, mitochondrial (AGK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[118]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[124]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]

Drug(s) Affected By Vesicle transport protein SFT2C (SFT2D3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[632]

Drug(s) Affected By Transmembrane protein 41B (TMEM41B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[159]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[287]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[178]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[181]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By Torsin-1A-interacting protein 1 (TOR1AIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[129]

Drug(s) Affected By Tetratricopeptide repeat protein 39A (TTC39A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[633]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[173]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[103]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[595]

Drug(s) Affected By Protein furry homolog (FRY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[282]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[231]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[234]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[634]

Drug(s) Affected By Probable E3 ubiquitin-protein ligase HECTD2 (HECTD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[150]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
OXYQUINOLINE	DMZVS9Y	Discovery agent	N.A.	Investigative	[113]

Drug(s) Affected By G-protein coupled receptor 157 (GPR157)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[325]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[177]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[173]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[177]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By Obscurin (OBSCN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[227]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[118]

Drug(s) Affected By G kinase-anchoring protein 1 (GKAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[245]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[241]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[383]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]

Drug(s) Affected By Protein TASOR 2 (TASOR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[220]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[383]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[256]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[129]

Drug(s) Affected By Sushi domain-containing protein 4 (SUSD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[293]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[387]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[549]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[564]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[635]

Drug(s) Affected By Proteasome adapter and scaffold protein ECM29 (ECPAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[96]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[172]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[103]

Drug(s) Affected By DENN domain-containing protein 4C (DENND4C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[210]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[231]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[549]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[248]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[129]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[148]

Drug(s) Affected By Pecanex-like protein 4 (PCNX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[636]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[575]
PARAOXON	DMN4ZKC	Discovery agent	N.A.	Investigative	[637]

Drug(s) Affected By Protein SPT2 homolog (SPTY2D1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[231]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[256]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[575]

Drug(s) Affected By CWF19-like protein 1 (CWF19L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[636]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[218]

Drug(s) Affected By U11/U12 small nuclear ribonucleoprotein 48 kDa protein (SNRNP48)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[386]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[181]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[256]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[91]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[575]

Drug(s) Affected By Tyrosine-protein kinase STYK1 (STYK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[168]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[346]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[177]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[250]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[91]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[282]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[300]

Drug(s) Affected By SPRY domain-containing SOCS box protein 3 (SPSB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[383]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[385]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[385]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[385]

Drug(s) Affected By E3 ubiquitin-protein ligase TRIM65 (TRIM65)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[574]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[218]

Drug(s) Affected By Leucine-rich repeat and fibronectin type-III domain-containing protein 4 (LRFN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[307]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[383]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[223]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[638]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[575]

Drug(s) Affected By Type-1 angiotensin II receptor-associated protein (AGTRAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[168]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[639]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[140]

Drug(s) Affected By Transmembrane protein 92 (TMEM92)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[155]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[177]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[640]

Drug(s) Affected By MICOS complex subunit MIC27 (APOOL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[159]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[220]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]

Drug(s) Affected By DnaJ homolog subfamily C member 14 (DNAJC14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[96]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[105]

Drug(s) Affected By TBC1 domain family member 9 (TBC1D9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[387]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[103]

Drug(s) Affected By Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[474]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[149]

Drug(s) Affected By Serine/threonine-protein kinase MARK2 (MARK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[220]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[484]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]

Drug(s) Affected By Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[191]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[641]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[641]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[144]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]

Drug(s) Affected By Probable C-mannosyltransferase DPY19L4 (DPY19L4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[118]

Drug(s) Affected By Coiled-coil domain-containing protein 186 (CCDC186)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[386]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[177]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[504]

Drug(s) Affected By C-myc promoter-binding protein (DENND4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[287]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[642]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[143]

Drug(s) Affected By Cytochrome P450 2U1 (CYP2U1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[213]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[643]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[292]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[417]

Drug(s) Affected By HAUS augmin-like complex subunit 6 (HAUS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[217]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[492]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[644]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]

Drug(s) Affected By Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (PIP4P1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[266]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[129]

Drug(s) Affected By Kinectin (KTN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[135]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[122]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[201]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[547]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[143]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]

Drug(s) Affected By Phosphatidylcholine:ceramide cholinephosphotransferase 1 (SGMS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[219]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[231]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[416]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[181]

Drug(s) Affected By Sodium-independent sulfate anion transporter (SLC26A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[577]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[228]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[146]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[201]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By RNA-binding protein MEX3D (MEX3D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[335]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[241]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]

Drug(s) Affected By Dynein axonemal assembly factor 5 (DNAAF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[605]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[256]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[638]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[118]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[575]

Drug(s) Affected By Syntaxin-12 (STX12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[282]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[221]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[411]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[150]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[155]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[248]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[233]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[535]

Drug(s) Affected By Protein FAM219A (FAM219A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[150]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[241]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[105]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[129]

Drug(s) Affected By Mitofusin-1 (MFN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[645]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[646]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[647]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[123]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]

Drug(s) Affected By Pleckstrin homology domain-containing family M member 2 (PLEKHM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[177]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[129]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[636]

Drug(s) Affected By Mitochondrial Rho GTPase 2 (RHOT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[474]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[265]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[265]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[184]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[118]

Drug(s) Affected By Xaa-Arg dipeptidase (PM20D2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[648]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[181]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]

Drug(s) Affected By Solute carrier family 38 member 6 (SLC38A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[577]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[258]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[162]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[241]

Drug(s) Affected By Abl interactor 1 (ABI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[416]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[371]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[129]

Drug(s) Affected By N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase (GCNT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[582]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[623]

Drug(s) Affected By Protein FAM43A (FAM43A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[649]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[168]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[179]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[219]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[133]

Drug(s) Affected By CAP-Gly domain-containing linker protein 4 (CLIP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[104]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[144]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[144]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[293]

Drug(s) Affected By Putative transporter SVOPL (SVOPL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[103]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By Polypeptide N-acetylgalactosaminyltransferase 4 (GALNT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[650]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[385]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[383]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[385]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[385]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[118]

Drug(s) Affected By Coiled-coil domain-containing protein 82 (CCDC82)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[293]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[177]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[256]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[636]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[91]

Drug(s) Affected By SH2 domain-containing protein 3C (SH2D3C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[137]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[176]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[383]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[140]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By Methyltransferase-like protein 27 (METTL27)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[383]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[299]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[636]

Drug(s) Affected By ADP-ribosylation factor GTPase-activating protein 1 (ARFGAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[651]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[129]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[652]

Drug(s) Affected By Protein KRI1 homolog (KRI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[96]

Drug(s) Affected By ATPase family gene 2 protein homolog A (AFG2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[105]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[91]

Drug(s) Affected By Equilibrative nucleobase transporter 1 (SLC43A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[464]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[315]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[315]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[127]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[592]

Drug(s) Affected By Retinol dehydrogenase 13 (RDH13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[635]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[201]

Drug(s) Affected By Neuropilin and tolloid-like protein 2 (NETO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[448]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[448]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[217]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[236]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]

Drug(s) Affected By Polyhomeotic-like protein 3 (PHC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[532]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[155]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[533]

Drug(s) Affected By Glutathione S-transferase C-terminal domain-containing protein (GSTCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[220]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[293]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[127]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[653]

Drug(s) Affected By Folliculin (FLCN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[149]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[654]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[245]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[96]

Drug(s) Affected By Tubulin--tyrosine ligase (TTL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[234]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[250]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[574]
2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE	DMNQL17	Discovery agent	N.A.	Investigative	[655]

Drug(s) Affected By Protein NEDD1 (NEDD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[177]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[181]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]

Drug(s) Affected By Protein FAM76A (FAM76A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]

Drug(s) Affected By Proline-rich protein 7 (PRR7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[307]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[248]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[515]

Drug(s) Affected By Transmembrane protein 254 (TMEM254)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[159]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[282]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[218]

Drug(s) Affected By Retinol dehydrogenase 11 (RDH11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[159]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[415]
Haloperidol	DM96SE0	Delirium		Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]

Drug(s) Affected By POC1 centriolar protein homolog B (POC1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[414]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[414]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[533]

Drug(s) Affected By Interferon-induced protein 44 (IFI44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[315]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[464]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[315]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[656]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[657]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[315]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[315]

Drug(s) Affected By Large ribosomal subunit protein uL30m (MRPL30)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[133]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[658]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[201]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[177]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[263]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[91]

Drug(s) Affected By RB1-inducible coiled-coil protein 1 (RB1CC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[659]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[244]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[566]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[660]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]

Drug(s) Affected By Elongator complex protein 5 (ELP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[335]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[162]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[201]

Drug(s) Affected By DDB1- and CUL4-associated factor 11 (DCAF11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[241]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[201]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[221]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[140]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[250]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]

Drug(s) Affected By Arginine/serine-rich protein PNISR (PNISR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[614]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[220]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[201]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]

Drug(s) Affected By General transcription factor 3C polypeptide 2 (GTF3C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[260]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[260]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[661]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[640]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[129]

Drug(s) Affected By Transmembrane protein 263 (TMEM263)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[218]
cycloheximide	DMGDA3C	Discovery agent	N.A.	Investigative	[662]

Drug(s) Affected By Protein THEM6 (THEM6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[663]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[263]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[664]

Drug(s) Affected By Pleckstrin homology-like domain family A member 1 (PHLDA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[187]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[179]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[162]

Drug(s) Affected By Hexosaminidase D (HEXD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[383]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[155]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[237]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[605]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[118]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF138 (RNF138)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[416]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein L-like (HNRNPLL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[194]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[605]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[129]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[282]

Drug(s) Affected By Uncharacterized protein C4orf3 (C4ORF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[144]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[144]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[144]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]

Drug(s) Affected By tRNA-splicing endonuclease subunit Sen15 (TSEN15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[230]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[123]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[177]

Drug(s) Affected By Palladin (PALLD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[187]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[425]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[168]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[104]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[162]

Drug(s) Affected By Protein N-lysine methyltransferase METTL21A (METTL21A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[302]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[179]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[293]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]

Drug(s) Affected By Histone acetyltransferase KAT6B (KAT6B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[160]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[144]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[144]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[144]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[265]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[144]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[293]

Drug(s) Affected By E3 ubiquitin-protein ligase rififylin (RFFL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[168]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[104]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[144]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[144]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[144]

Drug(s) Affected By Aquaporin-3 (AQP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[665]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[666]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[179]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[113]

Drug(s) Affected By Proteasome inhibitor PI31 subunit (PSMF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[265]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[265]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By Protein FAM168A (FAM168A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[251]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[251]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[248]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[118]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[282]

Drug(s) Affected By Protein NDRG1 (NDRG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[667]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[668]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[584]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[669]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[214]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[613]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[133]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]

Drug(s) Affected By TRAF family member-associated NF-kappa-B activator (TANK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[627]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[329]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[265]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[670]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[671]

Drug(s) Affected By Ras-related protein Rab-8B (RAB8B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[220]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[177]

Drug(s) Affected By GTP-binding protein Rit1 (RIT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[144]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[144]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[144]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[492]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[123]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]

Drug(s) Affected By Phosphorylase b kinase regulatory subunit beta (PHKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[177]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[416]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]

Drug(s) Affected By BLOC-2 complex member HPS3 (HPS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[177]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[672]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[603]

Drug(s) Affected By F-box/WD repeat-containing protein 7 (FBXW7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[558]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[673]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[674]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]

Drug(s) Affected By Polyamine deacetylase HDAC10 (HDAC10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[168]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[675]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[173]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[140]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]

Drug(s) Affected By NXPE family member 3 (NXPE3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[177]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[417]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[177]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[105]

Drug(s) Affected By Transmembrane protein 230 (TMEM230)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[129]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[636]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[201]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[218]

Drug(s) Affected By SOSS complex subunit B2 (NABP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]

Drug(s) Affected By Ankyrin repeat domain-containing protein 9 (ANKRD9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[220]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[676]

Drug(s) Affected By ADP-ribosylation factor-like protein 8A (ARL8A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[122]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[416]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[105]

Drug(s) Affected By m7GpppX diphosphatase (DCPS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[184]

Drug(s) Affected By Protein FAM241B (FAM241B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[96]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[140]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[105]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]

Drug(s) Affected By R3H domain-containing protein 4 (R3HDM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]

Drug(s) Affected By E3 ubiquitin-protein ligase CHFR (CHFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[168]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[246]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[677]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[677]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[678]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By ATP-dependent DNA helicase DDX11 (DDX11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[517]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[295]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[256]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[250]

Drug(s) Affected By Kelch domain-containing protein 7B (KLHDC7B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[227]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[148]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[679]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[680]

Drug(s) Affected By H/ACA ribonucleoprotein complex non-core subunit NAF1 (NAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[681]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[386]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[383]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[256]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[129]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[652]

Drug(s) Affected By Histone-lysine N-methyltransferase EHMT2 (EHMT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[253]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[411]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[335]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[411]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[682]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]

Drug(s) Affected By Uncharacterized protein C9orf85 (C9ORF85)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[149]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[347]

Drug(s) Affected By Pannexin-2 (PANX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[683]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[296]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[684]

Drug(s) Affected By Ribosomal protein S6 kinase delta-1 (RPS6KC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[248]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[129]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[514]

Drug(s) Affected By Structural maintenance of chromosomes protein 6 (SMC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Vitamin C	DMXJ7O8	Adenocarcinoma	2D40	Approved	[685]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[143]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[256]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[118]

Drug(s) Affected By Protein orai-2 (ORAI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[383]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[156]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]

Drug(s) Affected By E3 ubiquitin-protein ligase RING2 (RNF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[123]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[416]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]

Drug(s) Affected By Krueppel-like factor 6 (KLF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[187]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[686]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[112]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[687]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[214]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]

Drug(s) Affected By Succinate dehydrogenase cytochrome b560 subunit, mitochondrial (SDHC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[474]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[352]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[335]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[220]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[241]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]

Drug(s) Affected By Sigma non-opioid intracellular receptor 1 (SIGMAR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[688]
Bardoxolone methyl	DMODA2X	Mixed connective tissue disease	4A43.3	Phase 3	[689]
URSOLIC ACID	DM4SOAW	Metabolic syndrome x	5C50-5D2Z	Phase 2	[689]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[105]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[689]

Drug(s) Affected By Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[123]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[245]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[127]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[570]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]

Drug(s) Affected By Protein NipSnap homolog 1 (NIPSNAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[576]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[498]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[452]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[124]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[177]

Drug(s) Affected By Protein FAM118B (FAM118B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[230]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[218]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[575]

Drug(s) Affected By Target of rapamycin complex 2 subunit MAPKAP1 (MAPKAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[474]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[230]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[123]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[229]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[690]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[181]

Drug(s) Affected By TM2 domain-containing protein 3 (TM2D3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[96]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]

Drug(s) Affected By Ferroptosis suppressor protein 1 (AIFM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[118]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[411]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[179]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[144]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[144]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[148]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]

Drug(s) Affected By Tubulin-specific chaperone D (TBCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[118]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[691]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[248]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[118]

Drug(s) Affected By Iron-sulfur cluster assembly 1 homolog, mitochondrial (ISCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[149]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[215]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[127]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[176]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[143]

Drug(s) Affected By Bublin coiled-coil protein (BBLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[159]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[411]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[219]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[105]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[129]

Drug(s) Affected By Coiled-coil domain-containing protein 32 (CCDC32)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]

Drug(s) Affected By Kinesin-like protein KIFC1 (KIFC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[302]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[692]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[693]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[541]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]

Drug(s) Affected By Katanin p60 ATPase-containing subunit A-like 1 (KATNAL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[118]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[220]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[694]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By Protein C1orf43 (C1ORF43)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[230]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[192]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[150]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[574]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[575]

Drug(s) Affected By TM2 domain-containing protein 2 (TM2D2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[229]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[636]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[515]

Drug(s) Affected By Sphingosine-1-phosphate phosphatase 1 (SGPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[180]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[549]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[282]
bilirubin	DMI0V4O	Discovery agent	N.A.	Investigative	[695]

Drug(s) Affected By FSD1-like protein (FSD1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[219]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[177]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[230]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[533]

Drug(s) Affected By C-type lectin domain family 7 member A (CLEC7A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[464]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[278]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[696]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
Beta-D-Glucose	DM5IHYP	Discovery agent	N.A.	Investigative	[697]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[347]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[622]
Butanoic Acid	DMTAJP7	Discovery agent	N.A.	Investigative	[698]

Drug(s) Affected By Serrate RNA effector molecule homolog (SRRT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[381]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[135]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[201]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[181]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[504]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[129]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[636]

Drug(s) Affected By Protein kinase C and casein kinase substrate in neurons protein 1 (PACSIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[633]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[177]

Drug(s) Affected By Sterile alpha motif domain-containing protein 10 (SAMD10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[140]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]

Drug(s) Affected By ATP-binding cassette sub-family A member 2 (ABCA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[699]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[245]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[173]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[700]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[700]

Drug(s) Affected By INO80 complex subunit B (INO80B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[517]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[701]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[702]

Drug(s) Affected By Uncharacterized protein C6orf62 (C6ORF62)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[230]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[425]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[127]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[176]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]

Drug(s) Affected By Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[214]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[659]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[144]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[146]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[219]

Drug(s) Affected By Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (NUCKS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[235]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[123]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[236]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[703]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]

Drug(s) Affected By Oxysterol-binding protein-related protein 2 (OSBPL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[168]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[137]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[638]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[118]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[282]

Drug(s) Affected By Dual specificity protein phosphatase 15 (DUSP15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
RESORCINOL	DMM37C0	Discovery agent	N.A.	Investigative	[492]

Drug(s) Affected By BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 (KCTD10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[168]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[129]

Drug(s) Affected By UPF0696 protein C11orf68 (C11ORF68)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[184]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[143]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By Differentially expressed in FDCP 6 homolog (DEF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[180]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[704]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[704]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[103]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[296]

Drug(s) Affected By Sentrin-specific protease 3 (SENP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[129]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[582]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[605]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[636]

Drug(s) Affected By ESF1 homolog (ESF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[162]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[383]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[177]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[256]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[400]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]

Drug(s) Affected By RNA polymerase II-associated protein 3 (RPAP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[118]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[282]

Drug(s) Affected By Sin3 histone deacetylase corepressor complex component SDS3 (SUDS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[519]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[256]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[91]

Drug(s) Affected By Caspase activity and apoptosis inhibitor 1 (CAAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[230]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[143]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[256]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[129]

Drug(s) Affected By Kinesin-like protein KIF9 (KIF9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[416]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[118]

Drug(s) Affected By E3 ubiquitin-protein ligase SMURF2 (SMURF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[609]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[244]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[241]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[155]

Drug(s) Affected By Transcription factor IIIB 50 kDa subunit (BRF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[127]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[452]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[105]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]

Drug(s) Affected By Retinoid-inducible serine carboxypeptidase (SCPEP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[278]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[104]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[162]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]

Drug(s) Affected By POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[168]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[661]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[149]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[660]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[177]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[177]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[256]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By DNA dC->dU-editing enzyme APOBEC-3G (APOBEC3G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[127]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[241]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[705]
Isoflavone	DM7U58J	N. A.	N. A.	Phase 4	[706]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[140]

Drug(s) Affected By DnaJ homolog subfamily C member 4 (DNAJC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[162]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Indomethacin	DMSC4A7	Bursitis		Approved	[232]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[707]
Okadaic acid	DM47CO1	Discovery agent	N.A.	Investigative	[708]
L-serine	DM6WPIS	Pulmonary tuberculosis	1B10.Z	Investigative	[709]

Drug(s) Affected By DNA-directed DNA/RNA polymerase mu (POLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[523]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[523]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[523]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[523]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[234]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]
MK-886	DMT0O7H	Asthma	CA23	Discontinued in Phase 2	[710]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[129]

Drug(s) Affected By Carbohydrate sulfotransferase 11 (CHST11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[194]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[229]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[241]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[383]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[156]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]

Drug(s) Affected By Uncharacterized protein C14orf132 (C14ORF132)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[219]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[386]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[103]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[181]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[103]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By Putative RNA-binding protein Luc7-like 1 (LUC7L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[230]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[177]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[129]

Drug(s) Affected By Prefoldin subunit 4 (PFDN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[263]

Drug(s) Affected By Solute carrier family 35 member C2 (SLC35C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
[3H]methyltrienolone	DMTSGOW	Discovery agent	N.A.	Investigative	[711]
3-iodothyronamine	DM3L0F8	Discovery agent	N.A.	Investigative	[712]

Drug(s) Affected By Gephyrin (GPHN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[118]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[229]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[181]

Drug(s) Affected By Endophilin-B2 (SH3GLB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[184]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[534]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[347]
[3H]methyltrienolone	DMTSGOW	Discovery agent	N.A.	Investigative	[711]

Drug(s) Affected By Muscleblind-like protein 1 (MBNL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[150]
Indomethacin	DMSC4A7	Bursitis		Approved	[232]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[713]

Drug(s) Affected By CDC42 small effector protein 2 (CDC42SE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[177]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]
cycloheximide	DMGDA3C	Discovery agent	N.A.	Investigative	[662]

Drug(s) Affected By RNA-binding protein PNO1 (PNO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[413]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[220]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[383]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]

Drug(s) Affected By DDB1- and CUL4-associated factor 13 (DCAF13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[383]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[256]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[186]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[603]

Drug(s) Affected By FGFR1 oncogene partner 2 (FGFR1OP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[230]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[714]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[245]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[177]

Drug(s) Affected By DNA-directed RNA polymerase III subunit RPC5 (POLR3E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[168]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[127]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[96]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[417]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[256]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]

Drug(s) Affected By Anoctamin-10 (ANO10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[159]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[648]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[220]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[636]

Drug(s) Affected By BSD domain-containing protein 1 (BSDC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[448]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[383]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[129]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[91]

Drug(s) Affected By G patch domain-containing protein 2-like (GPATCH2L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[150]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[549]

Drug(s) Affected By Ceroid-lipofuscinosis neuronal protein 6 (CLN6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[383]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[129]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[347]

Drug(s) Affected By AFG2-interacting ribosome maturation factor (AIRIM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[230]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[383]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]

Drug(s) Affected By N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 (B3GNT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[231]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[220]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[234]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]

Drug(s) Affected By Opioid growth factor receptor (OGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[499]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[168]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[428]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[162]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[155]

Drug(s) Affected By E3 ubiquitin-protein ligase KCMF1 (KCMF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[415]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[416]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[181]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[184]

Drug(s) Affected By Stromal interaction molecule 2 (STIM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[230]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[549]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[113]

Drug(s) Affected By Inhibitor of Bruton tyrosine kinase (IBTK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[195]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[194]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[715]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[416]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[129]

Drug(s) Affected By Phosphatidylinositol 4-kinase beta (PI4KB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[136]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[143]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[129]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF14 (RNF14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[137]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[172]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
QUERCITRIN	DM1DH96	Discovery agent	N.A.	Investigative	[716]

Drug(s) Affected By Fibulin-5 (FBLN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[219]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[501]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[242]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[173]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[484]

Drug(s) Affected By Beta-1,4-galactosyltransferase 6 (B4GALT6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[717]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[282]

Drug(s) Affected By LIM domain-containing protein 1 (LIMD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[168]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[129]

Drug(s) Affected By Protein NDRG3 (NDRG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[220]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[177]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[99]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By LIM domain and actin-binding protein 1 (LIMA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[718]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]

Drug(s) Affected By AF4/FMR2 family member 4 (AFF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[719]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[177]

Drug(s) Affected By NADH-cytochrome b5 reductase 1 (CYB5R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[260]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[260]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[122]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[220]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[240]

Drug(s) Affected By Methyl-CpG-binding domain protein 1 (MBD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[168]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[720]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[721]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[143]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[256]

Drug(s) Affected By Oxidative stress-induced growth inhibitor 1 (OSGIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[144]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[144]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[144]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[144]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[144]

Drug(s) Affected By Cell division cycle protein 23 homolog (CDC23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[722]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[177]

Drug(s) Affected By Anaphase-promoting complex subunit 5 (ANAPC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[162]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[416]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[256]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[233]

Drug(s) Affected By Calcipressin-3 (RCAN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[293]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[173]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[177]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (ASAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[265]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[723]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[201]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[388]

Drug(s) Affected By Tetratricopeptide repeat protein 7A (TTC7A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[149]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[176]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[256]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[250]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[118]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[684]

Drug(s) Affected By Nucleosome assembly protein 1-like 2 (NAP1L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[400]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]

Drug(s) Affected By Protein PHTF1 (PHTF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[149]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[194]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[220]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[638]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]

Drug(s) Affected By 26S proteasome non-ATPase regulatory subunit 13 (PSMD13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[724]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
MG-132	DMKA2YS	N. A.	N. A.	Preclinical	[725]

Drug(s) Affected By Cytosolic carboxypeptidase 1 (AGTPBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[143]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[549]

Drug(s) Affected By Serine/threonine-protein kinase ICK (CILK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[258]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[220]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[218]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[91]
[3H]methyltrienolone	DMTSGOW	Discovery agent	N.A.	Investigative	[711]

Drug(s) Affected By Structural maintenance of chromosomes protein 3 (SMC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[162]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[726]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[199]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]

Drug(s) Affected By Myotubularin-related protein 6 (MTMR6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[727]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[177]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[102]

Drug(s) Affected By Phospholipase A-2-activating protein (PLAA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[245]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[105]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[237]

Drug(s) Affected By Phenylalanine--tRNA ligase alpha subunit (FARSA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[122]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[220]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[201]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]

Drug(s) Affected By Nck-associated protein 1 (NCKAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[728]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[574]

Drug(s) Affected By Kelch-like protein 20 (KLHL20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[148]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[123]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[143]

Drug(s) Affected By ARF GTPase-activating protein GIT1 (GIT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[129]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[534]

Drug(s) Affected By RING finger protein 11 (RNF11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[575]

Drug(s) Affected By Transformation/transcription domain-associated protein (TRRAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[118]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[302]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[229]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[96]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]

Drug(s) Affected By Carbohydrate sulfotransferase 2 (CHST2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[179]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[192]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[648]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[181]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[417]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[177]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By G-protein-signaling modulator 3 (GPSM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[210]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[177]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[684]

Drug(s) Affected By U6 snRNA-associated Sm-like protein LSm4 (LSM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[177]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[416]

Drug(s) Affected By DNA-directed RNA polymerase III subunit RPC8 (POLR3H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[383]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[181]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[606]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[218]

Drug(s) Affected By NEDD8 ultimate buster 1 (NUB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[123]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[137]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[177]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[118]

Drug(s) Affected By Selenoprotein K (SELENOK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[192]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[229]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[155]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]

Drug(s) Affected By Nuclear receptor coactivator 3 (NCOA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[381]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[729]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[614]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[162]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[282]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[265]

Drug(s) Affected By Numb-like protein (NUMBL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By ATPase MORC2 (MORC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[416]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[102]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[256]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[129]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[129]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[218]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[664]

Drug(s) Affected By Aldo-keto reductase family 1 member B10 (AKR1B10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[425]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[163]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[215]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[730]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[731]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[179]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[631]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[212]

Drug(s) Affected By Aldo-keto reductase family 1 member B1 (AKR1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[297]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[732]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[212]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[219]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[212]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[733]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[734]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[735]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[736]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[737]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[738]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[739]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[167]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[740]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[741]

Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[742]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[743]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[744]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[744]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[742]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[742]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[745]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[746]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]

Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[742]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[743]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[747]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[742]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[408]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[742]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[748]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]

Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[749]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[742]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[743]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[750]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[742]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[742]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[687]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[751]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[750]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[742]

Drug(s) Affected By ATP-binding cassette sub-family C member 2 (ABCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lopinavir	DMITQS0	Human immunodeficiency virus infection	1C62	Approved	[752]
Sulfinpyrazone	DMEV954	Gout	FA25	Approved	[753]
Probenecid	DMMFWOJ	Acute gonococcal cervicitis		Approved	[754]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[755]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[203]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[666]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[756]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[481]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[757]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]

Drug(s) Affected By Toll-like receptor 4 (TLR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[758]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[759]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[760]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[761]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[758]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[144]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[191]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[214]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[762]
Vismodegib	DM5IXKQ	Basal cell carcinoma	2C32	Approved	[763]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[764]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[765]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[766]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[572]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]

Drug(s) Affected By NF-kappa-B inhibitor epsilon (NFKBIE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[665]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[625]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[661]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[592]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[767]

Drug(s) Affected By Myc box-dependent-interacting protein 1 (BIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[307]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[768]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[286]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[112]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[769]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[285]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[770]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[771]
Selenium	DM25CGV	N. A.	N. A.	Approved	[772]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[112]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[773]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[168]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[773]

Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[774]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[775]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[776]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[774]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[777]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ibrutinib	DMHZCPO	Mantle cell lymphoma	2A85.5	Approved	[778]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[779]

Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[609]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[780]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[781]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[782]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[783]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[361]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]

Drug(s) Affected By Apoptosis regulatory protein Siva (SIVA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[285]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[144]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[144]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[144]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[784]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[785]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[786]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[787]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[788]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[411]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[789]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[790]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[791]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[792]

Drug(s) Affected By High affinity copper uptake protein 1 (SLC31A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[793]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[793]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[159]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[794]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
TRIENTINE	DMD2WPG	Inborn error of metabolism	5C50-5C59	Approved	[793]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[757]

Drug(s) Affected By CASP8 and FADD-like apoptosis regulator (CFLAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[557]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[795]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[665]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[796]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[797]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[616]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[792]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[798]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[799]

Drug(s) Affected By Histone-lysine N-methyltransferase SUV39H1 (SUV39H1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[187]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[118]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[214]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[497]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]

Drug(s) Affected By Serine protease HTRA2, mitochondrial (HTRA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[474]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[380]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[335]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[800]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[801]

Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[802]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[435]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[714]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[803]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[804]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[567]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[805]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]

Drug(s) Affected By Nuclear protein 1 (NUPR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[187]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[349]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[563]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[350]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[349]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[349]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[349]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[464]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[563]

Drug(s) Affected By Toll-like receptor 2 (TLR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[315]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[758]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[759]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[315]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[625]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[485]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[760]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[758]

Drug(s) Affected By DENN domain-containing protein 4B (DENND4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[177]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[140]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[153]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[187]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[264]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[425]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[191]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[472]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[217]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[444]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[264]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[771]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[692]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[214]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[335]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[179]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[806]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[192]

Drug(s) Affected By Natural cytotoxicity triggering receptor 1 (NCR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[327]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[293]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[248]
BAY11-7082	DMQNOFA	Multiple myeloma	2A83	Investigative	[807]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 gamma (GADD45G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[471]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[445]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[808]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[180]
Febuxostat	DMDEXQ0	Hyperuricaemia	5C55.Y	Approved	[809]

Drug(s) Affected By BAG family molecular chaperone regulator 3 (BAG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[557]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[260]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[567]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[260]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[329]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[810]

Drug(s) Affected By Apoptosis-inducing factor 1, mitochondrial (AIFM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[118]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[302]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[787]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[811]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[714]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[812]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[813]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[572]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[814]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[264]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[815]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[816]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[160]
Selenium	DM25CGV	N. A.	N. A.	Approved	[465]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[817]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[435]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[818]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]

Drug(s) Affected By Insulin-like growth factor II (IGF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dantrolene	DM1D8XY	Hyperthermia	MG26	Approved	[819]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[820]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[217]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[821]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[822]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[282]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[823]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[501]

Drug(s) Affected By Prelamin-A/C (LMNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[191]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[586]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[552]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[544]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[824]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]

Drug(s) Affected By RAF proto-oncogene serine/threonine-protein kinase (RAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[487]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[825]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[826]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[489]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[369]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[827]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[828]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[829]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[543]

Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trastuzumab	DMZQOUX	Breast cancer	2C60-2C65	Approved	[240]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[487]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[830]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[815]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[831]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[191]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[353]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[832]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[833]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[834]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[835]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[836]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[837]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[225]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[838]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[839]

Drug(s) Affected By Galectin-2 (LGALS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[382]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[383]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[173]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[840]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[840]

Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[264]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[503]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[841]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[842]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[843]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[428]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[844]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[845]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[846]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[315]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[847]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[187]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[649]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[848]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[849]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[667]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[850]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[851]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[315]

Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[852]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[852]
Ergonovine	DM0VEC1	Postpartum haemorrhage	JA43	Approved	[240]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[853]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[854]
Mizolastine	DM1FDN8	Allergic rhinitis	CA08.0	Approved	[855]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[856]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[857]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[858]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[859]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[860]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[566]
Fructose	DM43AN2	Vomiting	MD90	Approved	[240]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[861]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[410]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[264]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[423]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[230]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[862]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[863]

Drug(s) Affected By Cyclin-dependent kinase 1 (CDK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[471]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[864]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[784]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Selenium	DM25CGV	N. A.	N. A.	Approved	[465]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[788]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[584]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[191]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[687]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[353]

Drug(s) Affected By Integrin alpha-V (ITGAV)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[865]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[159]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[543]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[162]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]

Drug(s) Affected By Cathepsin B (CTSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[474]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[557]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[866]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Pyrimethamine	DM5X7VY	Malaria	1F40-1F45	Approved	[867]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[868]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[869]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[870]

Drug(s) Affected By Heat shock protein HSP 90-alpha (HSP90AA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[871]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[285]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[167]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[872]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[873]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[874]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[875]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]

Drug(s) Affected By Heat shock protein HSP 90-beta (HSP90AB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[336]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[503]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[322]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[874]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[876]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[260]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]

Drug(s) Affected By Growth-regulated alpha protein (CXCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[187]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[628]
Selenium	DM25CGV	N. A.	N. A.	Approved	[877]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[168]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[165]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[214]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[315]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[158]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[878]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[879]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[444]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[649]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[880]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[849]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[546]
Selenium	DM25CGV	N. A.	N. A.	Approved	[881]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[859]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[882]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[191]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[187]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[883]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[884]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[787]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[885]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[886]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[885]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[887]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[888]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[889]

Drug(s) Affected By Heat shock 70 kDa protein 1A (HSPA1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[890]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[444]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[264]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[872]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[322]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[876]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[891]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[892]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[893]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[649]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[410]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[849]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[740]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[393]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[894]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[740]

Drug(s) Affected By C-C motif chemokine 3 (CCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[848]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[876]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[843]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[381]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[382]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[895]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[896]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[896]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[848]

Drug(s) Affected By Cytochrome c oxidase subunit 8A, mitochondrial (COX8A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carfilzomib	DM48K0X	Multiple myeloma	2A83	Approved	[897]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[220]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[140]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[898]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[574]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[218]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[202]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[899]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[900]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[901]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[902]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[240]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[187]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[903]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[904]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[905]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[583]

Drug(s) Affected By Osteopontin (SPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[906]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[167]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[907]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[908]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[558]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[909]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[475]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[403]

Drug(s) Affected By Growth hormone receptor (GHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[387]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[623]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[105]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[118]

Drug(s) Affected By Parathyroid hormone-related protein (PTHLH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[168]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[910]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[911]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[912]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[104]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[282]

Drug(s) Affected By Interferon-induced transmembrane protein 1 (IFITM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[168]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[214]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[226]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[159]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[179]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[227]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]

Drug(s) Affected By Protein Cripto (CRIPTO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[913]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[648]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[149]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[293]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[914]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[103]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[848]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[167]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[915]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[667]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[916]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[188]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[859]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[917]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[918]

Drug(s) Affected By Tissue factor (F3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[919]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[920]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[921]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[922]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[923]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[924]
Fructose	DM43AN2	Vomiting	MD90	Approved	[925]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[926]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[920]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[243]

Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[471]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[864]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[423]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Selenium	DM25CGV	N. A.	N. A.	Approved	[465]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[788]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[886]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[927]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[411]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[692]

Drug(s) Affected By Interleukin-1 receptor type 1 (IL1R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[285]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[118]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[352]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[928]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[928]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]

Drug(s) Affected By Transcription factor 4 (TCF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[118]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[929]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[930]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[160]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[929]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[179]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[162]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[931]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[560]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[932]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[933]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[934]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[935]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[936]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[937]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[938]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[939]

Drug(s) Affected By Interleukin-7 receptor subunit alpha (IL7R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[620]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[136]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[192]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[532]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[940]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[941]

Drug(s) Affected By Heat shock 70 kDa protein 6 (HSPA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[444]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[264]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[874]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[214]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[843]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[942]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[875]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]

Drug(s) Affected By Transcription factor JunB (JUNB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[410]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[167]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[213]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[943]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[944]

Drug(s) Affected By CCAAT/enhancer-binding protein beta (CEBPB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[187]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[168]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[945]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[946]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[947]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[214]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[115]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]

Drug(s) Affected By Early growth response protein 1 (EGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[444]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[168]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[449]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[876]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[843]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[948]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[448]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[875]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[444]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[411]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[949]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[687]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[950]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[215]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[260]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[264]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[770]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[411]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[844]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[951]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[207]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[952]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[389]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[879]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[412]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[264]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[445]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[953]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[954]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[945]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[585]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[616]

Drug(s) Affected By Interleukin-10 (IL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[856]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[955]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[956]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[510]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[957]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[958]
Bisoprolol	DM3UZ95	Hypertension	BA00-BA04	Approved	[959]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[960]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[878]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[731]

Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[471]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[864]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[961]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[962]
Selenium	DM25CGV	N. A.	N. A.	Approved	[465]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[886]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[963]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[665]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[964]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[353]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[557]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[787]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[965]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[966]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[558]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[967]
Fructose	DM43AN2	Vomiting	MD90	Approved	[925]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[557]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[115]

Drug(s) Affected By DnaJ homolog subfamily B member 1 (DNAJB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[968]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[444]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[872]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[115]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[260]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[207]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[249]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[806]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[415]

Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[240]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[969]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[285]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[849]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[546]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[774]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[970]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[780]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[586]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]

Drug(s) Affected By Pentraxin-related protein PTX3 (PTX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[877]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[971]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[501]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[194]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[972]

Drug(s) Affected By CD27 antigen (CD27)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[169]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[567]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[329]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[973]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[133]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[292]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[140]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[974]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[975]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[976]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[977]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[905]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[978]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[979]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[980]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[981]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[982]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[983]

Drug(s) Affected By Calreticulin (CALR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[302]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[322]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[984]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[532]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[985]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[986]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[122]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[987]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[976]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[988]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[989]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[990]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[975]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[240]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[285]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[905]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[978]

Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 6 (PTPN6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[991]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[192]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Sodium chloride	DMM3950	Skin burns	ME65.0	Approved	[992]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[993]

Drug(s) Affected By SHC-transforming protein 1 (SHC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[446]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[335]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[361]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[727]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[512]

Drug(s) Affected By Nitric oxide synthase 1 (NOS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[557]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[994]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[165]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[995]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[165]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[996]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[329]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[997]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[998]
Interferon gamma-1b	DMWUMRL	Chronic granulomatous disease	4A00.0Y	Approved	[240]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[999]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[1000]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[225]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[583]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1001]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[434]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[1002]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[1003]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[817]

Drug(s) Affected By DNA replication licensing factor MCM7 (MCM7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[471]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[1004]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[616]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[214]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[464]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[504]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[861]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1005]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[558]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1006]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1007]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1008]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1009]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[1010]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[1011]

Drug(s) Affected By Replication protein A 14 kDa subunit (RPA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[471]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[214]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[567]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[193]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[430]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[1012]

Drug(s) Affected By Pro-adrenomedullin (ADM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[499]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[771]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[625]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[879]

Drug(s) Affected By Insulin receptor substrate 1 (IRS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[815]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[179]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[1013]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[104]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[444]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[1014]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[264]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[770]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[337]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[339]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1015]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[692]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]

Drug(s) Affected By Alpha-synuclein (SNCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[162]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[106]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[133]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[727]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[137]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[1016]

Drug(s) Affected By Breast cancer type 1 susceptibility protein (BRCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[187]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[1017]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1018]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[584]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[191]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[449]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[343]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[214]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[468]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[499]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[423]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[785]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[1019]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[788]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[1020]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[886]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[112]

Drug(s) Affected By Small ribosomal subunit protein eS19 (RPS19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1021]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[323]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[183]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[1012]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[547]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[1022]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1023]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[1024]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[835]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[1025]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[1026]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1027]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[1028]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[1029]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[969]

Drug(s) Affected By Caspase-2 (CASP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[904]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1030]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[168]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[1031]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1032]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[567]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[813]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[1033]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1034]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[861]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1035]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[546]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[862]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[616]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[845]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[1036]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[862]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[1037]

Drug(s) Affected By Mitogen-activated protein kinase 9 (MAPK9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[861]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[862]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[1038]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1039]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[862]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1040]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[1041]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]

Drug(s) Affected By Proliferation marker protein Ki-67 (MKI67)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[1042]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[692]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[129]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[214]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[464]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[803]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[617]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1043]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[1044]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[1045]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1046]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[1020]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[1038]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1047]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[1048]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1049]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[1050]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1051]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1052]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[118]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1053]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1054]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[966]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1055]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[876]
Fructose	DM43AN2	Vomiting	MD90	Approved	[925]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1056]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[1057]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[798]

Drug(s) Affected By Caspase-4 (CASP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[285]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[264]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[423]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[714]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[871]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1058]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[572]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[104]

Drug(s) Affected By Isocitrate dehydrogenase subunit alpha, mitochondrial (IDH3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[474]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1059]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[1060]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[897]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[199]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[124]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[770]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[557]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[1061]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1062]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[665]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[876]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[226]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[475]

Drug(s) Affected By Small ribosomal subunit protein mS29 (DAP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[360]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[283]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[329]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[1063]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[726]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[124]

Drug(s) Affected By Breast cancer type 2 susceptibility protein (BRCA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[487]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[449]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[625]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]

Drug(s) Affected By Interleukin-1 receptor-associated kinase 1 (IRAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[191]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[616]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[213]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1064]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1065]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[1066]

Drug(s) Affected By DNA mismatch repair protein Msh6 (MSH6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[471]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[112]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]

Drug(s) Affected By Caspase-7 (CASP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[1067]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[264]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1068]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[1069]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[1070]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[1070]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[191]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[945]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1071]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[938]

Drug(s) Affected By Caspase-6 (CASP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[285]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[447]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[586]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[1072]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[871]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[249]

Drug(s) Affected By Hepatocyte nuclear factor 3-alpha (FOXA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[557]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[167]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1073]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[557]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[175]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]

Drug(s) Affected By BH3-interacting domain death agonist (BID)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[285]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[787]
Selenium	DM25CGV	N. A.	N. A.	Approved	[772]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[616]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[213]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1074]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1075]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[390]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]

Drug(s) Affected By Histone deacetylase 4 (HDAC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[118]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[558]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[335]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[1076]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[229]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]

Drug(s) Affected By NACHT, LRR and PYD domains-containing protein 12 (NLRP12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[625]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[1077]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[224]

Drug(s) Affected By Beta-2-microglobulin (B2M)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[1078]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[302]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[1079]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[381]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1021]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[1080]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[1081]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[1082]

Drug(s) Affected By C-C motif chemokine 8 (CCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[444]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[244]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[219]
Morphine	DMRMS0L	Advanced cancer	2A00-2F9Z	Approved	[1083]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By Cytochrome c (CYCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[285]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[358]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[883]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[1084]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[338]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[1069]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[359]
Pefloxacin	DM49IGF	Gonococcal urethritis	1A70.0Y	Approved	[1085]

Drug(s) Affected By Heat shock factor protein 1 (HSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1086]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[1087]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[1087]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1088]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[873]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[1087]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[1087]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[1087]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1087]

Drug(s) Affected By Nuclear factor NF-kappa-B p100 subunit (NFKB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[285]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[264]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[191]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[213]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[429]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1065]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[576]

Drug(s) Affected By E3 ubiquitin-protein ligase Mdm2 (MDM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[285]
Flucytosine	DM13VTW	Cryptococcal meningitis		Approved	[1089]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[1089]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1090]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[191]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1091]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[833]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[260]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[1092]

Drug(s) Affected By Dystonin (DST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[118]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[335]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[149]

Drug(s) Affected By Heat shock factor protein 2 (HSF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[217]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[256]
MG-132	DMKA2YS	N. A.	N. A.	Preclinical	[1093]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[282]

Drug(s) Affected By DNA repair protein RAD51 homolog 1 (RAD51)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[471]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[784]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1094]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[1095]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[214]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1096]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[1097]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]

Drug(s) Affected By Fragile X messenger ribonucleoprotein 1 (FMR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[149]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[1098]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
M3541	DMG98QO	Solid tumour/cancer	2A00-2F9Z	Phase 1	[1098]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[534]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[899]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[969]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[187]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[903]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[557]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[1084]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[1019]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[1099]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[886]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[225]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1100]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[787]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1101]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[191]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[1089]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[797]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[616]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[876]

Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[905]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[557]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[1102]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[665]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[1103]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[558]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[843]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[557]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[1104]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[799]

Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[687]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[260]
Quinolones	DM5GVHU	Bacterial infection	1A00-1C4Z	Approved	[1105]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1106]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[249]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[144]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 1 (NAIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[329]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[973]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1107]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[1108]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[383]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[1109]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[1110]

Drug(s) Affected By Chromatin assembly factor 1 subunit A (CHAF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[112]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[129]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[214]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[112]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[133]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]

Drug(s) Affected By S-phase kinase-associated protein 2 (SKP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[187]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[692]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1111]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1112]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]

Drug(s) Affected By Serine-protein kinase ATM (ATM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[1113]
Paromomycin	DM1AGXN	Amoebiasis	1A36	Approved	[1114]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1018]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[788]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[558]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[803]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[260]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[681]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[591]

Drug(s) Affected By Bcl-2-interacting killer (BIK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1115]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[447]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1116]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[243]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1117]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[1118]

Drug(s) Affected By Interleukin-18 receptor 1 (IL18R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[656]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[219]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[671]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[658]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[177]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[1119]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[640]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[454]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 3 (BIRC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[1120]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[969]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[118]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[787]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[191]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[213]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[115]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[591]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[1121]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 2 (BIRC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[1120]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[969]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[797]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[226]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[804]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[1122]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1123]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[1121]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[1124]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[1125]

Drug(s) Affected By Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[609]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[207]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1126]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[207]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1127]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[329]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]

Drug(s) Affected By Cullin-1 (CUL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[264]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[429]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[102]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[99]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By Cullin-3 (CUL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[260]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[104]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[260]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[149]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[122]

Drug(s) Affected By Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[444]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[425]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[787]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[935]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[380]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1128]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[843]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[311]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[260]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[1129]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1130]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[1131]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[285]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1053]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1132]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[787]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[1133]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]

Drug(s) Affected By Transcription elongation factor A protein-like 1 (TCEAL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[104]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[492]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[220]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[241]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[325]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[505]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By Interferon regulatory factor 4 (IRF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[175]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[210]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[292]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[221]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[1135]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[1136]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
T-5224	DMD3CUJ	Rheumatoid arthritis	FA20	Discontinued in Phase 2	[1137]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[474]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[880]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[264]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[393]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[1138]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[396]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[397]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[1139]

Drug(s) Affected By Hsp90 co-chaperone Cdc37 (CDC37)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[352]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[567]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[136]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[129]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[636]

Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[1140]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1141]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[191]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1142]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[334]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[871]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1143]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[1144]

Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[1145]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1146]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[1147]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[1147]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1148]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1149]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[1150]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[558]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[266]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[437]

Drug(s) Affected By Carbonic anhydrase 9 (CA9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetazolamide	DM1AF5U	Absence epilepsy		Approved	[1151]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1148]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[868]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[179]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[227]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[113]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[517]

Drug(s) Affected By TIR domain-containing adapter molecule 2 (TICAM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[625]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[210]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[103]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[105]

Drug(s) Affected By Cell division cycle and apoptosis regulator protein 1 (CCAR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[122]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[614]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[122]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[122]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[1152]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[1153]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[177]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[1154]

Drug(s) Affected By Ectodysplasin-A receptor-associated adapter protein (EDARADD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[223]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By DNA-binding death effector domain-containing protein 2 (DEDD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[260]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[260]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[1155]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[152]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[383]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]

Drug(s) Affected By Heat shock protein 105 kDa (HSPH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[876]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[115]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[260]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[567]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[806]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[875]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]

Drug(s) Affected By CREB-binding protein (CREBBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[353]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1156]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[411]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[1157]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[931]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[183]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[1158]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[194]

Drug(s) Affected By Histone acetyltransferase KAT2B (KAT2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[191]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1156]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[183]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[1076]

Drug(s) Affected By Bcl-2-like protein 2 (BCL2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[167]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1160]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[875]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[329]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[973]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[1161]

Drug(s) Affected By N-alpha-acetyltransferase 80 (NAA80)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[133]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[514]

Drug(s) Affected By MOB kinase activator 3A (MOB3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[241]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[1162]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[118]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 7 (BIRC7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1160]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[294]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[1109]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[1163]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[1163]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[1163]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[1164]

Drug(s) Affected By NACHT, LRR and PYD domains-containing protein 3 (NLRP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[285]
Selenium	DM25CGV	N. A.	N. A.	Approved	[877]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1165]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1166]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[1167]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[761]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1168]
Atropine	DMEN6X7	Organophosphate poisoning	NE6Z	Approved	[1169]

Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[787]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[411]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[935]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[1170]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[687]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[843]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[1171]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1117]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[805]

Drug(s) Affected By Tribbles homolog 3 (TRIB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[444]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[215]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[307]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[115]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[260]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[403]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[115]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[179]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[806]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]

Drug(s) Affected By Cell growth regulator with EF hand domain protein 1 (CGREF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[210]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[177]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[1172]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[177]

Drug(s) Affected By Myeloid differentiation primary response protein MyD88 (MYD88)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[285]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[191]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[669]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[260]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[567]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[260]

Drug(s) Affected By Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[444]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[115]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1173]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1174]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[444]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[693]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[1173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Racecadotril	DMFOTZ7	Diarrhea	ME05.1	Approved	[1175]

Drug(s) Affected By Fanconi anemia group D2 protein (FANCD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[471]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[692]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[214]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[1176]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[210]

Drug(s) Affected By Eukaryotic translation initiation factor 2A (EIF2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[770]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[1177]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1178]
Cerulenin	DM6N4PR	Weight loss	MG43.5	Approved	[1179]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[415]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[572]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]

Drug(s) Affected By DNA replication factor Cdt1 (CDT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[187]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[687]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[214]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[464]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]

Drug(s) Affected By Interleukin-23 subunit alpha (IL23A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[315]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[169]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[315]
Misoprostol	DMHVJFK	Medical abortion	JA00.1Z	Approved	[1180]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[11]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[315]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[315]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[315]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[220]

Drug(s) Affected By Transcription factor 7-like 2 (TCF7L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[791]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[931]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[194]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[123]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[150]

Drug(s) Affected By Diablo IAP-binding mitochondrial protein (DIABLO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[474]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[302]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[787]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[380]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[558]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1181]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1075]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[181]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]

Drug(s) Affected By Sphingosine kinase 1 (SPHK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[307]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[543]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[127]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]

Drug(s) Affected By Anaphase-promoting complex subunit 11 (ANAPC11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[155]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[636]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[218]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[514]

Drug(s) Affected By Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[1182]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[264]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[337]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[337]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1183]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[337]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[844]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[951]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[952]

Drug(s) Affected By Lipid transferase CIDEB (CIDEB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[215]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[297]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[430]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[329]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[215]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[670]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[671]

Drug(s) Affected By Adenine DNA glycosylase (MUTYH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1184]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1185]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[118]

Drug(s) Affected By Cell cycle progression protein 1 (CCPG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[118]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[625]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[113]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Indomethacin	DMSC4A7	Bursitis		Approved	[1186]

Drug(s) Affected By FAS-associated factor 1 (FAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[118]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[329]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[229]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[96]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]

Drug(s) Affected By Transcription factor 19 (TCF19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[784]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[504]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[501]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-5 (ATF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[243]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[227]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[661]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[1187]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[219]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[312]

Drug(s) Affected By Rho-related BTB domain-containing protein 2 (RHOBTB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[220]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[174]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[252]

Drug(s) Affected By Beclin-1 (BECN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[1188]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[187]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1189]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[191]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1190]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[1191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1192]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1193]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1194]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[1195]

Drug(s) Affected By Palmitoyl thioesterase CPT1C (CPT1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[606]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[636]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[282]

Drug(s) Affected By Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (ATP2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[411]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[411]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[1196]

Drug(s) Affected By Histone deacetylase 6 (HDAC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[198]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[1197]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1198]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[1199]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[416]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1200]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[1200]

Drug(s) Affected By Serine/threonine-protein kinase 4 (STK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[150]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[143]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[513]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[1033]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[1201]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[187]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[904]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[1084]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1202]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[787]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[1203]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[1133]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[1204]

Drug(s) Affected By Transcription factor SOX-8 (SOX8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[149]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[133]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[383]

Drug(s) Affected By DNA repair endonuclease XPF (ERCC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[567]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[138]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[1176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[210]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1205]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[1206]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[293]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[1207]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[1208]

Drug(s) Affected By Polyunsaturated fatty acid lipoxygenase ALOX12 (ALOX12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1209]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[179]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[104]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[1210]
Masoprocol	DMMVNZ0	Prostate cancer	2C82.0	Approved	[1209]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[1209]
BAICALEIN	DM4C7E6	Influenza virus infection	1E30-1E32	Phase 2	[1209]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[314]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[218]

Drug(s) Affected By Heat shock protein beta-1 (HSPB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[474]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[611]
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[510]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[260]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[375]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[117]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[627]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[177]

Drug(s) Affected By Peroxisome proliferator-activated receptor delta (PPARD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[211]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1211]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1212]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[179]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[1213]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[1214]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[576]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[546]
Selenium	DM25CGV	N. A.	N. A.	Approved	[877]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[315]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[397]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[1215]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1216]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[165]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[213]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1217]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[464]

Drug(s) Affected By Unconventional myosin-Va (MYO5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1218]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1219]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[95]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[234]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[177]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[181]

Drug(s) Affected By Proteasome subunit beta type-5 (PSMB5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[159]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[92]
Sibutramine	DMFJTDI	Obesity	5B81	Approved	[1220]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Ardeparin	DMYRX8B	Deep vein thrombosis	BD71	Approved	[1221]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[1222]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[143]
WP-1066	DMUGHWR	Recurrent glioblastoma	2A00.00	Phase 1/2	[1222]
MG-132	DMKA2YS	N. A.	N. A.	Preclinical	[1223]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[263]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[1224]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[1045]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1225]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[1019]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[435]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1226]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[1227]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1228]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[353]

Drug(s) Affected By Mannose-binding protein C (MBL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[215]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[215]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[492]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[94]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[105]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[128]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[141]

Drug(s) Affected By Nucleophosmin (NPM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[503]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[322]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[551]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[874]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1229]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[323]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]

Drug(s) Affected By BRCA1-associated RING domain protein 1 (BARD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[143]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[321]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[91]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[541]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[93]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[492]

Drug(s) Affected By General transcription and DNA repair factor IIH helicase subunit XPB (ERCC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[119]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[329]
Dihydroxyacetone	DMM1LG2	Sunburn	EJ40	Approved	[1230]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[1206]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[261]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[98]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[385]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[385]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[143]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[1231]

Drug(s) Affected By Insulin-like growth factor 1 receptor (IGF1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[1232]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1233]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[1003]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1234]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[558]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1235]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[614]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[189]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[144]

Drug(s) Affected By Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[1182]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[264]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1236]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[337]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1237]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[337]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[114]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[844]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[951]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[337]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cationic trypsinogen (PRSS1)	TT2WR1T	TRY1_HUMAN	Inhibitor	[4]
Kallikrein-related peptidase (KLK)	TT5L2VC	NOUNIPROTAC	Inhibitor	[4]
Proteasome (PS)	TTU7ZMG	NOUNIPROTAC	Modulator	[5]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[6]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4) Main DME	DE4LYSA	CP3A4_HUMAN	Substrate	[7]
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Substrate	[8]
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Substrate	[9]
Mephenytoin 4-hydroxylase (CYP2C19) Main DME	DEGTFWK	CP2CJ_HUMAN	Substrate	[8]
Cytochrome P450 1A2 (CYP1A2) Main DME	DEJGDUW	CP1A2_HUMAN	Substrate	[10]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
14-3-3 protein epsilon	OT3WQXNA	1433E_HUMAN	Gene/Protein Processing	[11]
14-3-3 protein sigma (SFN)	OTLJCZ1U	1433S_HUMAN	Gene/Protein Processing	[11]
14-3-3 protein zeta/delta	OT2TKG9P	1433Z_HUMAN	Gene/Protein Processing	[11]
2-oxoglutarate dehydrogenase complex component E1 (OGDH)	OTHGTQWF	ODO1_HUMAN	Gene/Protein Processing	[11]
26S proteasome non-ATPase regulatory subunit 12 (PSMD12)	OTWICA51	PSD12_HUMAN	Gene/Protein Processing	[11]
26S proteasome non-ATPase regulatory subunit 13 (PSMD13)	OTNQ351N	PSD13_HUMAN	Gene/Protein Processing	[11]
26S proteasome non-ATPase regulatory subunit 7 (PSMD7)	OT7PZZ4K	PSMD7_HUMAN	Gene/Protein Processing	[11]
26S proteasome regulatory subunit 6B (PSMC4)	OTS3XN41	PRS6B_HUMAN	Gene/Protein Processing	[11]
5'-nucleotidase (NT5E)	OT7J5LT6	5NTD_HUMAN	Gene/Protein Processing	[11]
5-hydroxytryptamine receptor 2B (HTR2B)	OTM1AD9J	5HT2B_HUMAN	Gene/Protein Processing	[11]

References

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• [2] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
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• [7] Relative contributions of the five major human cytochromes P450, 1A2, 2C9, 2C19, 2D6, and 3A4, to the hepatic metabolism of the proteasome inhibitor bortezomib. Drug Metab Dispos. 2005 Nov;33(11):1723-8.
• [8] Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
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• [15] Arriva-ProMetic recombinant alpha 1-antitrypsin (rAAT) moves into the clinic for dermatology applications. ProMetic Life Sciences. 2009.
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• [18] Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation. J Med Chem. 2009 Sep 24;52(18):5732-47.
• [19] Development of serine protease inhibitors displaying a multicentered short (<2.3 A) hydrogen bond binding mode: inhibitors of urokinase-type plasmi... J Med Chem. 2001 Aug 16;44(17):2753-71.
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