Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMXT7WG)

• Drug Name: Deguelin Drug Info
• Synonyms: 522-17-8; (-)-Deguelin; (-)-cis-deguelin; DEGUELIN(-); UNII-K5Z93K66IE; CHEBI:4357; K5Z93K66IE; MFCD01740600; C23H22O6; (7as,13as)-13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-3h-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7(7ah)-one; (7aS,13aS)-9,10-Dimethoxy-3,3-dimethyl-13,13a-dihydro-3H-pyrano[2,3-c:6,5-f']dichromen-7(7aH)-one; (7aS,13aS)-9,10-dimethoxy-3,3-dimethyl-13,13a-dihydro-3H-pyrano[2,3-c:6,5-f']dichromen-7(7aH)-one.; SR-01000597503; CCRIS 8104; Deguelin/; (-)-Deguelin, Mundulea sericea; Spectrum_001044; Tocris-1770; Spectrum2_000298; Spectrum3_001122; Spectrum4_001965; Spectrum5_001852; SCHEMBL73183; BSPBio_002583; KBioGR_002434; KBioSS_001524; SPECTRUM201138; MLS006010295; SPBio_000236; CHEMBL393417; KBio2_001524; KBio2_004092; KBio2_006660; KBio3_002083; DTXSID10200231; HMS1923A05; HMS3268E12; 3H-Bis(1)benzopyrano(3,4-b:6',5'-e)pyran-7(7aH)-one, 13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-, (7aS-cis)-; EX-A4158; ZINC3978987; 1702AH; ABP000411; BDBM50505204; CCG-39856; LMPK12060019; s8132; AKOS024456769; ACN-053693; BCP9000596; CS-1802; SDCCGMLS-0066380.P001; NCGC00025288-01; NCGC00025288-02; NCGC00025288-03; (-)-Deguelin, >98% (HPLC), powder; AS-56004; HY-13425; SMR004701363; C10417; Q5251862; SR-01000597503-1; SR-01000597503-3; SR-01000597503-4; BRD-K61401890-001-02-0; BRD-K61401890-001-03-8; BRD-K61401890-001-04-6; (1S,14S)-17,18-dimethoxy-7,7-dimethyl-2,8,21-trioxapentacyclo[12.8.0.03,12.04,9.015,20]docosa-3(12),4(9),5,10,15,17,19-heptaen-13-one; (7aS,13aS)-9,10-Dimethoxy-3,3-dimethyl-13,13a-dihydro-3H,7aH-pyrano[2,3-c;6,5-f']dichromen-7-one; 13,13aS-Dihydro-9,10-dimethoxy-3,3-dimethyl-3H-[1]benzopyrano[3,4-b]pyrano[2,3-h][1]benzopyran-7(7aS)-one; 3H-[1]Benzopyrano[3,4-b]pyrano[2,3-h][1]benzopyran-7(7aH)-one, 13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-, (7aS,13aS)-; 3H-Bis(1)benzopyrano(3,4-b:6',5'-e)pyran-7(7aH)-one, 13,13a-dihydro-9,10-dimethoxy-3,3-dimethyl-, (7aS,13aS)-

Indication

Disease Entry	ICD 11	Status	REF
Esophageal squamous cell carcinoma	2E60.1	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 107935
  ChEBI ID: CHEBI:4357
  CAS Number: CAS 522-17-8
  TTD Drug ID: DMXT7WG

Molecule-Related Drug Atlas

Drug(s) Targeting Aurora kinase B (AURKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
AT9283	DMQ94CT	Solid tumour/cancer	2A00-2F9Z	Phase 3	[5]
PHA-739358	DMGYBZI	Prostate cancer	2C82.0	Phase 2	[6]
VX-680	DM93YKJ	Solid tumour/cancer	2A00-2F9Z	Phase 2	[7]
ABT-348	DMMZOYN	Haematological malignancy	2B33.Y	Phase 2	[8]
HPP-607	DM5VSZR	Solid tumour/cancer	2A00-2F9Z	Phase 1	[9]
CYC116	DMUMHXT	Solid tumour/cancer	2A00-2F9Z	Phase 1	[10]
AMG 900	DMASGXJ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[11]
SNS-314	DMAC5F2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[12]
BI-847325	DMY4B6J	Solid tumour/cancer	2A00-2F9Z	Phase 1	[13]
R763	DME0CJ9	Haematological malignancy	2B33.Y	Phase 1	[14]

Drug(s) Affected By CCAAT/enhancer-binding protein alpha (CEBPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[15]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[18]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[19]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[20]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[24]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[25]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[27]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[28]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[29]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[30]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[34]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[35]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[36]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[37]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[38]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[39]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[40]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[41]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[42]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[43]

Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[44]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[45]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[46]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[47]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[48]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[52]

Drug(s) Affected By Endothelial PAS domain-containing protein 1 (EPAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[58]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ketorolac	DMI4EL5	Postoperative inflammation	1A00-CA43.1	Approved	[58]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[63]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[26]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[67]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[27]

Drug(s) Affected By Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[69]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[70]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[71]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[72]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[73]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[75]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[52]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[72]

Drug(s) Affected By Metalloproteinase inhibitor 1 (TIMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pentoxifylline	DMU3DNC	Alcoholic hepatitis	DB94.1	Approved	[76]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[77]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[78]
Selenium	DM25CGV	N. A.	N. A.	Approved	[79]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[78]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[82]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[83]

Drug(s) Affected By Interstitial collagenase (MMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[84]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[85]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[86]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[87]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[88]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[89]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[90]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[94]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[95]
Fructose	DM43AN2	Vomiting	MD90	Approved	[76]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[96]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[97]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[70]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[100]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[101]

Drug(s) Affected By Matrilysin (MMP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[88]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[104]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[107]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[108]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[109]

Drug(s) Affected By Metalloproteinase inhibitor 2 (TIMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[111]
Selenium	DM25CGV	N. A.	N. A.	Approved	[79]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[113]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[82]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[30]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[114]
Tetracaine	DM9J6C2	Spinal anesthesia	MB40.3	Approved	[115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[117]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[118]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[119]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[120]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[121]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[122]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[76]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[124]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[125]

Drug(s) Affected By Nitric oxide synthase, inducible (NOS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Indomethacin	DMSC4A7	Bursitis		Approved	[126]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[127]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[111]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[88]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[129]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[131]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[132]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[133]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[134]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[135]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[136]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[137]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[138]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[139]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[140]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[141]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[142]

Drug(s) Affected By Collagenase 3 (MMP13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[143]
Clindamycin	DM15HL8	Acne vulgaris	ED80	Approved	[144]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[143]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[145]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[146]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[147]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[148]
Doxycycline	DM7ICNU	Acne vulgaris	ED80	Approved	[144]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[149]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[150]

Drug(s) Affected By Transforming protein RhoA (RHOA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[24]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[88]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[151]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[152]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[153]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[154]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[155]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[156]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[157]

Drug(s) Affected By Son of sevenless homolog 1 (SOS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[158]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[149]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[159]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]

Drug(s) Affected By Rho-associated protein kinase 1 (ROCK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[161]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[163]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[164]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[165]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[156]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[166]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 3 (MAP3K3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[152]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[63]
Romidepsin	DMT5GNL	Cutaneous T-cell lymphoma	2B01	Approved	[168]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[169]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[170]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[171]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]

Drug(s) Affected By Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[69]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[70]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[72]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[72]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[172]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[72]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[75]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[52]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[173]

Drug(s) Affected By Putative cytochrome P450 2D7 (CYP2D7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]

Drug(s) Affected By DENN domain-containing protein 3 (DENND3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[174]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[164]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[176]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[27]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[177]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[178]

Drug(s) Affected By Golgi pH regulator A (GPR89A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[179]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[180]

Drug(s) Affected By Potassium channel subfamily K member 1 (KCNK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[184]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[185]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[185]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[186]

Drug(s) Affected By E3 SUMO-protein ligase CBX4 (CBX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[187]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[63]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[188]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[190]
Romidepsin	DMT5GNL	Cutaneous T-cell lymphoma	2B01	Approved	[168]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]

Drug(s) Affected By Pyruvate dehydrogenase protein X component, mitochondrial (PDHX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[81]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[193]

Drug(s) Affected By Importin-5 (IPO5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[177]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[194]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Indomethacin	DMSC4A7	Bursitis		Approved	[196]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]

Drug(s) Affected By Dynamin-1-like protein (DNM1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[197]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[198]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[200]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[201]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[197]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[202]

Drug(s) Affected By Interferon-related developmental regulator 1 (IFRD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[203]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[204]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[205]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[206]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[207]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[16]

Drug(s) Affected By Claudin-5 (CLDN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[208]
Guanfacine extended release	DMB1CZ8	Attention deficit hyperactivity disorder	6A05.Z	Approved	[209]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[210]
Glycine	DMIOZ29	Allergic rhinitis	CA08.0	Approved	[211]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[212]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
CS-600G	DM1PV4Y	N. A.	N. A.	Phase 3	[213]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[214]
LY294002	DMY1AFS	Neuroblastoma	2D11.2	Phase 1	[215]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[211]

Drug(s) Affected By Serine/threonine-protein kinase 25 (STK25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[216]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[217]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[217]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[177]

Drug(s) Affected By Suppressor of cytokine signaling 2 (SOCS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[153]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[114]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[220]

Drug(s) Affected By Neurocan core protein (NCAN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[222]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[223]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[224]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[57]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[225]

Drug(s) Affected By Protein arginine N-methyltransferase 5 (PRMT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[226]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]

Drug(s) Affected By Telomerase reverse transcriptase (TERT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[227]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[228]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[93]
Selenium	DM25CGV	N. A.	N. A.	Approved	[229]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[230]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[231]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[232]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[233]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[234]

Drug(s) Affected By Serine/threonine-protein kinase Chk1 (CHEK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[84]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[235]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[236]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[237]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[238]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[239]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[240]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[241]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[242]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[243]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[244]
Selenium	DM25CGV	N. A.	N. A.	Approved	[245]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[241]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[246]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[247]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[246]

Drug(s) Affected By Peripheral plasma membrane protein CASK (CASK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[248]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[164]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[250]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[252]

Drug(s) Affected By Aurora kinase A (AURKA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[203]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[253]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[255]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[253]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]

Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[256]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[257]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[258]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[259]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[260]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]

Drug(s) Affected By Centrin-3 (CETN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[261]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[262]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[263]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[263]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[264]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[265]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[266]

Drug(s) Affected By V-type proton ATPase subunit e 1 (ATP6V0E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[267]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[268]
Bortezomib	DMNO38U	Leukemia		Approved	[269]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[184]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[270]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[195]

Drug(s) Affected By Nuclear valosin-containing protein-like (NVL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[252]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[271]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[27]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[272]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[273]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[274]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[275]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[276]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[277]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[278]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[253]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[279]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[280]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[281]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[282]

Drug(s) Affected By Glutamate receptor ionotropic, NMDA 2D (GRIN2D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[188]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]

Drug(s) Affected By ATP-binding cassette sub-family C member 4 (ABCC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[283]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[284]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[285]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[286]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[287]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[288]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[207]

Drug(s) Affected By ATP-binding cassette sub-family C member 5 (ABCC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[283]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[289]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[290]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[291]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[292]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[285]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[293]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[288]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]

Drug(s) Affected By CASP8 and FADD-like apoptosis regulator (CFLAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[294]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[295]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[296]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[297]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[298]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[282]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[299]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[300]

Drug(s) Affected By Tapasin (TAPBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[177]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[225]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[301]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[302]

Drug(s) Affected By ATP-dependent RNA helicase DHX15 (DHX15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[303]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[303]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[57]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[304]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[305]

Drug(s) Affected By Ribosomal RNA-processing protein 8 (RRP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[184]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[27]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[27]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[306]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[307]

Drug(s) Affected By D-3-phosphoglycerate dehydrogenase (PHGDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[308]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[308]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[309]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[309]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]

Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 12 (ADAM12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[310]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[311]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[312]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[313]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[314]

Drug(s) Affected By ATM interactor (ATMIN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[315]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[186]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[26]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[316]

Drug(s) Affected By Histone-lysine N-methyltransferase SUV39H1 (SUV39H1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[317]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[177]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[318]
Bortezomib	DMNO38U	Leukemia		Approved	[319]

Drug(s) Affected By Protein Mis18-beta (OIP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[320]

Drug(s) Affected By Aflatoxin B1 aldehyde reductase member 2 (AKR7A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[321]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[190]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[322]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[323]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[324]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[325]

Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[326]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[327]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[328]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[329]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[330]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[331]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[332]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[164]

Drug(s) Affected By Neuronal migration protein doublecortin (DCX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[247]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[333]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[333]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[334]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[335]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[336]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[225]

Drug(s) Affected By Zinc finger protein SNAI2 (SNAI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[337]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[338]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]

Drug(s) Affected By Dual specificity tyrosine-phosphorylation-regulated kinase 3 (DYRK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[340]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[341]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[171]

Drug(s) Affected By Calumenin (CALU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[207]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[342]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[342]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[343]

Drug(s) Affected By Double-strand-break repair protein rad21 homolog (RAD21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[292]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[344]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[345]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[185]
Fenretinide	DMRD5SP	Macular degeneration	9B78.3	Phase 3	[346]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[347]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[348]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[349]

Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[177]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[350]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[351]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[352]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[30]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[114]

Drug(s) Affected By Kinesin heavy chain isoform 5C (KIF5C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[342]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Haloperidol	DM96SE0	Delirium		Approved	[342]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[107]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[342]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[342]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[186]

Drug(s) Affected By Catenin delta-1 (CTNND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[177]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[295]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[247]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[110]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[353]

Drug(s) Affected By Histone H2B type 1-K (H2BC12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[292]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[261]

Drug(s) Affected By E3 ubiquitin-protein ligase TRIM13 (TRIM13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[247]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[186]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[354]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[355]

Drug(s) Affected By Low-density lipoprotein receptor-related protein 4 (LRP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[356]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]

Drug(s) Affected By Copine-3 (CPNE3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[342]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[342]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[269]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[171]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[357]

Drug(s) Affected By Reticulon-2 (RTN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[358]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[264]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[359]

Drug(s) Affected By Hyaluronan mediated motility receptor (HMMR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[292]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[253]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[253]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]

Drug(s) Affected By Cell division control protein 45 homolog (CDC45)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[84]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[174]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[104]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]

Drug(s) Affected By Serine/arginine-rich splicing factor 10 (SRSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[250]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[322]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[360]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[361]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[81]

Drug(s) Affected By KH domain-containing, RNA-binding, signal transduction-associated protein 3 (KHDRBS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[362]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[164]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[225]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[341]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[323]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[184]

Drug(s) Affected By Ribonuclease P protein subunit p40 (RPP40)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[363]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[264]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[177]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[355]

Drug(s) Affected By ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial (CLPX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[364]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Josamycin	DMKJ8LB	Bacterial infection	1A00-1C4Z	Approved	[365]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[366]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[180]

Drug(s) Affected By DNA fragmentation factor subunit beta (DFFB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[367]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[351]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[331]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[206]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]

Drug(s) Affected By Signal recognition particle subunit SRP72 (SRP72)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[268]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[63]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[304]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[270]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[357]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]

Drug(s) Affected By Slit homolog 2 protein (SLIT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[177]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[311]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[368]

Drug(s) Affected By Transcription factor SOX-30 (SOX30)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[369]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[264]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]

Drug(s) Affected By G2/mitotic-specific cyclin-B2 (CCNB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[84]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[274]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[370]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[371]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[205]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]

Drug(s) Affected By Dual specificity protein phosphatase 14 (DUSP14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[70]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[244]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[241]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[372]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[164]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[241]

Drug(s) Affected By Elongator complex protein 1 (ELP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[351]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[351]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[373]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]

Drug(s) Affected By Kinesin-like protein KIF20A (KIF20A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[203]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[241]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]

Drug(s) Affected By SAM pointed domain-containing Ets transcription factor (SPDEF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[264]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[186]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[374]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[375]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[376]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
Oxalic Acid	DMLN2GQ	Discovery agent	N.A.	Investigative	[377]

Drug(s) Affected By E3 ubiquitin-protein ligase ARIH2 (ARIH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[311]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[378]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[358]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[184]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[316]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[177]

Drug(s) Affected By Transcription factor SOX-14 (SOX14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]

Drug(s) Affected By BAG family molecular chaperone regulator 3 (BAG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[294]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[351]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[331]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[268]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[351]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[63]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[379]

Drug(s) Affected By Zinc finger protein SNAI1 (SNAI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[140]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[337]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[338]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[380]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[381]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[382]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[383]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[384]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[210]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 17 (PPP1R17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[385]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[385]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[386]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[184]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[225]

Drug(s) Affected By G1/S-specific cyclin-E2 (CCNE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[84]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[274]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[241]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[247]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[387]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[174]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[388]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[307]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[309]

Drug(s) Affected By Glutathione reductase, mitochondrial (GSR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[389]
Ketoprofen	DMRKXPT	Bursitis		Approved	[76]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[390]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[391]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[392]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[393]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[394]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[351]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[395]

Drug(s) Affected By Hypoxanthine-guanine phosphoribosyltransferase (HPRT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[396]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[397]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[398]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Fructose	DM43AN2	Vomiting	MD90	Approved	[399]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[400]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]

Drug(s) Affected By Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[401]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[402]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[403]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[404]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[405]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[406]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[70]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[292]
Selenium	DM25CGV	N. A.	N. A.	Approved	[79]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[407]

Drug(s) Affected By Phosphoglycerate kinase 1 (PGK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[295]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[408]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[351]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[154]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[409]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[410]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[411]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]

Drug(s) Affected By Argininosuccinate synthase (ASS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[412]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[413]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[164]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[412]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[159]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[414]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[70]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[291]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[415]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[93]
Selenium	DM25CGV	N. A.	N. A.	Approved	[416]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[417]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[327]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[418]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]

Drug(s) Affected By GTPase NRas (NRAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[419]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[420]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[149]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[155]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[421]

Drug(s) Affected By Platelet-derived growth factor subunit B (PDGFB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[422]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[423]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[424]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[425]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[426]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[425]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[223]

Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[427]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[76]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[428]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[429]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[430]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[431]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[432]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[433]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]

Drug(s) Affected By Ferritin light chain (FTL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[422]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[235]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[434]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[435]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[436]

Drug(s) Affected By Ferritin heavy chain (FTH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[422]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[434]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[437]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[247]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[438]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[439]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[267]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[309]

Drug(s) Affected By Metallothionein-2 (MT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[440]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[317]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[235]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[441]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[442]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[351]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[154]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[443]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[309]

Drug(s) Affected By NADH-ubiquinone oxidoreductase chain 6 (ND6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[444]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[148]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[193]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[272]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[195]

Drug(s) Affected By Glucocorticoid receptor (NR3C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[445]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[140]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[446]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[447]

Drug(s) Affected By High affinity nerve growth factor receptor (NTRK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[448]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[449]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[311]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[450]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[171]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[451]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[452]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[453]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[454]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[37]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[455]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[456]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[457]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[458]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[459]

Drug(s) Affected By Metallothionein-1E (MT1E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[460]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[351]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[461]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[462]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[463]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[464]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[465]

Drug(s) Affected By Heat shock protein beta-1 (HSPB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[216]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[372]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[351]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[413]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[466]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]

Drug(s) Affected By Guanine nucleotide-binding protein G(i) subunit alpha-2 (GNAI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[467]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[250]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]

Drug(s) Affected By Histone H2A type 1-B/E (H2AC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[317]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[207]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[468]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[190]

Drug(s) Affected By Lupus La protein (SSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[469]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[159]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[250]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[470]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[27]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[27]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[366]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[195]

Drug(s) Affected By Keratin, type I cytoskeletal 18 (KRT18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[294]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[177]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[471]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[472]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[473]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[474]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]

Drug(s) Affected By Myosin light chain 1/3, skeletal muscle isoform (MYL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[342]
Norepinephrine	DMOUC09	Alopecia	ED70	Approved	[475]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[386]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[314]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]

Drug(s) Affected By Tyrosine-protein kinase Fyn (FYN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[476]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[477]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[478]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[479]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[480]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[341]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[481]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[482]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[45]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[483]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[248]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[327]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[484]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[236]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[485]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[387]

Drug(s) Affected By Cyclin-dependent kinase 1 (CDK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[84]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[486]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[274]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Selenium	DM25CGV	N. A.	N. A.	Approved	[416]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[278]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[487]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[88]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[387]

Drug(s) Affected By Nucleophosmin (NPM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[203]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[408]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[472]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[488]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[489]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[411]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]

Drug(s) Affected By Beta-hexosaminidase subunit alpha (HEXA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[184]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[490]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[76]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[491]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
PP-242	DM2348V	Discovery agent	N.A.	Investigative	[492]

Drug(s) Affected By Neurofilament light polypeptide (NEFL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[153]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[149]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[301]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[153]

Drug(s) Affected By Histone H1.0 (H1-0)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[154]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[356]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[493]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[358]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]

Drug(s) Affected By Asialoglycoprotein receptor 1 (ASGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[263]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[171]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[171]

Drug(s) Affected By Cathepsin D (CTSD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[494]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[292]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[495]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[496]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[497]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[409]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]

Drug(s) Affected By Calpain-1 catalytic subunit (CAPN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[44]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[498]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[328]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[499]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[500]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[501]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]

Drug(s) Affected By Beta-hexosaminidase subunit beta (HEXB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Pyrimethamine	DM5X7VY	Malaria	1F40-1F45	Approved	[502]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[268]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[263]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[503]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[190]
Dextromethorphan	DMUDJZM	Allergic rhinitis	CA08.0	Approved	[504]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]

Drug(s) Affected By Heat shock protein HSP 90-alpha (HSP90AA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[505]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[140]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[506]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[507]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[488]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[508]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]

Drug(s) Affected By Insulin-like growth factor 1 receptor (IGF1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[509]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[510]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[511]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[512]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[513]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[514]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[515]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[309]

Drug(s) Affected By Amino acid transporter heavy chain SLC3A2 (SLC3A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[253]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[516]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[204]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[351]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[204]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[309]

Drug(s) Affected By Heat shock protein HSP 90-beta (HSP90AB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[44]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[203]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[408]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[488]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[351]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]

Drug(s) Affected By Asparagine synthetase (ASNS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[460]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[517]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[203]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[517]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[253]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[308]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[518]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[517]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]

Drug(s) Affected By Synaptophysin (SYP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[248]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[333]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[519]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[333]
Abacavir	DMMN36E	Human immunodeficiency virus infection	1C62	Approved	[520]
Methamphetamine	DMPM4SK	Anxiety		Approved	[521]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[358]

Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[85]
Selenium	DM25CGV	N. A.	N. A.	Approved	[79]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[522]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[523]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[524]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[525]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[82]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[83]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[526]

Drug(s) Affected By Collagen alpha-2(IV) chain (COL4A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[294]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[412]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[412]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[294]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[527]

Drug(s) Affected By Fibroblast growth factor 2 (FGF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[528]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[529]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[530]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[531]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[532]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[533]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[154]
Isradipine	DMA5XGH	Hypertension	BA00-BA04	Approved	[534]
Valdecoxib	DMAY7H4	Osteoarthritis	FA00-FA05	Approved	[535]

Drug(s) Affected By Gamma-enolase (ENO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[536]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[537]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[538]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[539]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[309]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[309]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[540]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[460]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[541]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[542]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[543]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[544]
Selenium	DM25CGV	N. A.	N. A.	Approved	[545]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[546]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[547]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[88]

Drug(s) Affected By Complement C1s subcomponent (C1S)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[381]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[301]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[527]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[317]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[548]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[549]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[277]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[550]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[551]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[550]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[552]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[553]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[554]

Drug(s) Affected By Histone H2A type 1 (H2AC11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[317]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[307]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[310]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[373]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]

Drug(s) Affected By Pepsin A-5 (PGA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[314]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]

Drug(s) Affected By Heat shock 70 kDa protein 1A (HSPA1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[555]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[460]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[70]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[506]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[235]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[408]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]

Drug(s) Affected By Calmodulin-1 (CALM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[253]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[88]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[253]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[267]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]

Drug(s) Affected By Transcriptional activator GLI3 (GLI3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[556]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[557]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[341]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[558]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[315]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[559]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[560]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[359]

Drug(s) Affected By Myb-related protein A (MYBL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[561]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[562]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[340]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[561]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[563]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[267]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[268]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[562]

Drug(s) Affected By Lysosomal alpha-glucosidase (GAA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[177]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[110]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[564]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[564]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[376]

Drug(s) Affected By Retinoic acid receptor alpha (RARA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[294]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[140]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[565]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[309]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[309]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[309]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[309]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[566]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[567]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[356]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[568]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[569]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[570]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[571]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[76]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[317]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[572]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[573]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[124]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[574]

Drug(s) Affected By Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (DLAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[575]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[342]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[342]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[368]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[263]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase F (PTPRF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[268]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[373]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]

Drug(s) Affected By COUP transcription factor 1 (NR2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[576]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[164]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[577]

Drug(s) Affected By Transforming growth factor beta-3 proprotein (TGFB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[530]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[140]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[381]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[443]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[149]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]

Drug(s) Affected By cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[292]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[154]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[389]
Mitotane	DMU1GX0	Adrenocortical carcinoma	2D11.Z	Approved	[578]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[579]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[580]

Drug(s) Affected By Mast/stem cell growth factor receptor Kit (KIT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[581]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[529]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[582]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[268]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[583]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[584]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[301]

Drug(s) Affected By 60 kDa heat shock protein, mitochondrial (HSPD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[203]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[408]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[247]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[473]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[412]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[585]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[351]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[586]

Drug(s) Affected By Microtubule-associated protein 2 (MAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[292]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[587]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[247]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[56]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[334]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]

Drug(s) Affected By Heat shock cognate 71 kDa protein (HSPA8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[44]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[70]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[203]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[292]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[408]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[473]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[588]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[589]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[508]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[590]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[513]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[591]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[592]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[342]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[593]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[292]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[593]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[516]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]

Drug(s) Affected By Ras-related protein Ral-A (RALA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[140]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[594]

Drug(s) Affected By Lysosome-associated membrane glycoprotein 1 (LAMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[342]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[595]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[596]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[597]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[342]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[598]

Drug(s) Affected By DNA topoisomerase 2-alpha (TOP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[599]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[600]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[601]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[602]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[603]

Drug(s) Affected By Glucose-6-phosphate 1-dehydrogenase (G6PD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[76]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[342]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[140]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[391]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[392]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[604]

Drug(s) Affected By C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[206]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[263]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[263]

Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[605]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[606]
Selenium	DM25CGV	N. A.	N. A.	Approved	[416]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[607]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[88]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[608]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[609]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[387]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]

Drug(s) Affected By Ornithine decarboxylase (ODC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[317]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[610]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[611]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[612]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[153]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[613]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[267]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[614]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[466]

Drug(s) Affected By Neurofilament heavy polypeptide (NEFH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[529]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[206]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[615]
Scopolamine	DMOM8AL	Addictive disorder	6C50-6C5Z	Approved	[616]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[617]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[190]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[618]

Drug(s) Affected By ADP/ATP translocase 1 (SLC25A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[57]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[619]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[63]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]

Drug(s) Affected By ADP/ATP translocase 3 (SLC25A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[342]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[342]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[620]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[26]

Drug(s) Affected By Myosin light chain 4 (MYL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[3]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[373]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[315]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[621]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[622]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[294]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[337]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[623]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[624]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[625]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[626]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[627]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]

Drug(s) Affected By Proto-oncogene tyrosine-protein kinase Src (SRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bosutinib	DMTI8YE	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[628]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[629]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[630]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[631]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[632]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[106]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]

Drug(s) Affected By Metallothionein-1G (MT1G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[460]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[235]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[351]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[563]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[633]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[462]

Drug(s) Affected By Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (MTHFD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[253]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[204]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[204]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[204]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[268]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]

Drug(s) Affected By D(2) dopamine receptor (DRD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Droperidol	DM0DXA8	Nausea	MD90	Approved	[76]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[76]
Zuclopenthixol	DMKYD5N	Schizophrenia	6A20	Approved	[76]
Meglitinides	DM1OFHN	Type-2 diabetes	5A11	Approved	[634]
Sulpiride	DMF54ZG	Schizophrenia	6A20	Approved	[635]
Risperidone	DMN6DXL	Bipolar I disorder		Approved	[636]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[637]
Methamphetamine	DMPM4SK	Anxiety		Approved	[638]
Bromocriptine	DMVE3TK	Acromegaly	5A60.0	Approved	[639]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[640]

Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[84]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[486]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Selenium	DM25CGV	N. A.	N. A.	Approved	[416]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[278]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[551]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[641]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[253]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[642]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[140]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[643]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[644]
Selenium	DM25CGV	N. A.	N. A.	Approved	[79]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[645]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[552]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[296]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[646]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[647]

Drug(s) Affected By Protein C-ets-1 (ETS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[648]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[253]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[149]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[556]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[301]

Drug(s) Affected By Aldo-keto reductase family 1 member B1 (AKR1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[205]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[649]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[435]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[301]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[435]

Drug(s) Affected By B-lymphocyte antigen CD19 (CD19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[57]
GSK618334	DMJPXZ4	Drug abuse	6C4G.1Z	Phase 1	[650]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
CATECHIN	DMY38SB	Discovery agent	N.A.	Investigative	[651]

Drug(s) Affected By Fos-related antigen 1 (FOSL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[652]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[32]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[371]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[653]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[654]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[206]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[443]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[309]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[655]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[422]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[656]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[657]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[437]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[658]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[659]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[660]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[661]

Drug(s) Affected By Small ribosomal subunit protein uS5 (RPS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[443]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[81]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[662]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[271]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[27]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[306]

Drug(s) Affected By N-chimaerin (CHN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[663]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[315]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[622]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[177]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[270]

Drug(s) Affected By Transcription factor 4 (TCF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[177]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[47]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[664]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[47]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[206]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[567]

Drug(s) Affected By Mucin-1 (MUC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[665]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[536]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[666]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[666]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[667]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[668]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[669]

Drug(s) Affected By CD44 antigen (CD44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[561]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Selenium	DM25CGV	N. A.	N. A.	Approved	[670]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[338]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[671]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[672]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[673]

Drug(s) Affected By Carbonyl reductase 1 (CBR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[674]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[301]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[421]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[675]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[421]

Drug(s) Affected By SH2/SH3 adapter protein NCK1 (NCK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[57]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[301]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[676]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[677]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[322]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[323]

Drug(s) Affected By Histone H1.2 (H1-2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[309]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[309]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]

Drug(s) Affected By Methylated-DNA--protein-cysteine methyltransferase (MGMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[678]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[477]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[679]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[680]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[681]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[682]
Dacarbazine	DMNPZL4	Adenocarcinoma	2D40	Approved	[683]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[684]

Drug(s) Affected By Heat shock 70 kDa protein 6 (HSPA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[460]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[70]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[235]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[488]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[131]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[685]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[508]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]

Drug(s) Affected By Aspartate aminotransferase, cytoplasmic (GOT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[686]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[206]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[309]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[309]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[309]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[687]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[309]

Drug(s) Affected By Transcription factor JunB (JUNB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[97]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[140]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[688]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[689]

Drug(s) Affected By cAMP-dependent protein kinase catalytic subunit alpha (PRKACA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[190]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[690]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[691]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[57]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[176]

Drug(s) Affected By CCAAT/enhancer-binding protein beta (CEBPB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[317]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[247]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[158]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[692]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[693]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[204]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]

Drug(s) Affected By Neuromodulin (GAP43)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[78]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[78]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[694]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[148]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[114]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[695]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[268]
Megestrol	DMDH9KX	Breast cancer	2C60-2C65	Approved	[78]

Drug(s) Affected By Neuronal acetylcholine receptor subunit beta-2 (CHRNB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[363]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Atropine	DMEN6X7	Organophosphate poisoning	NE6Z	Approved	[696]
Galantamine	DMEO794	Alzheimer disease	8A20	Approved	[696]
Rivastigmine	DMG629M	Alzheimer disease	8A20	Approved	[696]
Scopolamine	DMOM8AL	Addictive disorder	6C50-6C5Z	Approved	[696]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[264]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[697]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[698]
CYTISINE	DMUF0BJ	Tobacco dependence	6C4A.2	Phase 3	[699]

Drug(s) Affected By CTP synthase 1 (CTPS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[174]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[268]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[421]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[110]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[700]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[701]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[421]

Drug(s) Affected By ATP-dependent 6-phosphofructokinase, liver type (PFKL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Penfluridol	DMG1DTE	Schizophrenia	6A20	Approved	[702]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[26]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[491]

Drug(s) Affected By Insulin-like growth factor-binding protein 2 (IGFBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[652]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[479]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[413]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[703]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[268]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]

Drug(s) Affected By Arylamine N-acetyltransferase 1 (NAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Procainamide	DMNMXR8	Ventricular arrhythmias	BC71	Approved	[704]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[705]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[706]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[704]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[704]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[188]

Drug(s) Affected By Large ribosomal subunit protein uL22 (RPL17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[707]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[267]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[662]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[271]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[27]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[306]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[70]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[243]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[248]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[253]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[75]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[52]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[32]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[173]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[708]

Drug(s) Affected By Cadherin-2 (CDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[248]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[661]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[333]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[709]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[710]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[711]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[712]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[149]

Drug(s) Affected By DNA-directed RNA polymerases I, II, and III subunit RPABC1 (POLR2E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[469]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[713]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[714]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[715]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[270]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[180]

Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 2 (EIF2S2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[30]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[716]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[309]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[421]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[358]
Vitamin C	DMXJ7O8	Adenocarcinoma	2D40	Approved	[717]

Drug(s) Affected By Annexin A7 (ANXA7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[342]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[718]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[366]

Drug(s) Affected By Cyclin-A2 (CCNA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[24]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[486]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[291]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[235]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[226]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[484]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[145]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[719]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]

Drug(s) Affected By Aromatic-L-amino-acid decarboxylase (DDC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[720]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[721]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[184]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[722]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[723]

Drug(s) Affected By Calpastatin (CAST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[411]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[268]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[322]

Drug(s) Affected By Cytochrome P450 3A5 (CYP3A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[724]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[725]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[726]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[726]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[727]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[728]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[729]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[730]

Drug(s) Affected By V-type proton ATPase subunit B, brain isoform (ATP6V1B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[342]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[342]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[306]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[355]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[731]

Drug(s) Affected By Filamin-A (FLNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[732]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[411]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[733]

Drug(s) Affected By Synaptotagmin-1 (SYT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[247]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[734]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[311]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[735]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[736]

Drug(s) Affected By Catechol O-methyltransferase (COMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[737]
Dobutamine	DMD1B8Z	Heart failure	BD10-BD13	Approved	[737]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[737]
Modafinil	DMYILBE	Malignant glioma	2A00.0	Approved	[738]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[737]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[140]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[248]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[739]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]

Drug(s) Affected By Cadherin-3 (CDH3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[248]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[661]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[661]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[222]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[740]

Drug(s) Affected By cAMP-dependent protein kinase catalytic subunit beta (PRKACB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[351]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[351]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[269]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[741]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[421]

Drug(s) Affected By NAD-dependent malic enzyme, mitochondrial (ME2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[315]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Josamycin	DMKJ8LB	Bacterial infection	1A00-1C4Z	Approved	[365]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[316]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]

Drug(s) Affected By Glycine dehydrogenase (GLDC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[468]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[421]

Drug(s) Affected By Small ribosomal subunit protein uS3 (RPS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[342]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[342]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[342]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[742]

Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[743]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[744]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[745]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[746]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[327]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[747]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[748]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[749]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[750]

Drug(s) Affected By Brain-derived neurotrophic factor (BDNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[751]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[140]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[752]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Bupivacaine	DM4PRFC	Anaesthesia	9A78.6	Approved	[753]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[754]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]

Drug(s) Affected By Eukaryotic translation initiation factor 4B (EIF4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[755]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[756]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[757]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[110]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[81]

Drug(s) Affected By Endothelial transcription factor GATA-2 (GATA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[292]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[758]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[759]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[68]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[760]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[761]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[574]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[762]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[402]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[483]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[763]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[417]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[764]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[460]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[70]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[765]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[766]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[253]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[767]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[768]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[769]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[770]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[771]

Drug(s) Affected By Elongation factor 1-beta (EEF1B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[488]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[579]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[580]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[27]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[772]

Drug(s) Affected By Tenascin (TNC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[530]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[661]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[661]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[363]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[207]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[3]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[301]

Drug(s) Affected By G1/S-specific cyclin-E1 (CCNE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[317]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[773]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[226]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[551]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[484]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[774]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[775]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[776]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[777]

Drug(s) Affected By Signal transducer CD24 (CD24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[203]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[247]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[778]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[779]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[57]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]

Drug(s) Affected By Guanylyl cyclase C (GUCY2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[225]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[110]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[314]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[177]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[225]

Drug(s) Affected By DNA replication licensing factor MCM3 (MCM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[84]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[15]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[174]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[371]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[443]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]

Drug(s) Affected By Bromodomain-containing protein 2 (BRD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[309]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[309]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[309]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[294]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[235]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[277]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[780]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[781]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[513]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[782]
Fructose	DM43AN2	Vomiting	MD90	Approved	[399]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[294]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[204]

Drug(s) Affected By DnaJ homolog subfamily B member 1 (DNAJB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[586]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[460]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[506]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[204]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[351]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[32]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[439]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[783]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[443]

Drug(s) Affected By Cathepsin S (CTSS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[784]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[381]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[784]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[301]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[784]
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[785]

Drug(s) Affected By Proteasome subunit alpha type-1 (PSMA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[786]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[342]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[787]
NVP-AUY922	DMTYXQF	Multiple myeloma	2A83	Phase 2	[788]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[176]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[122]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[118]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[789]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[124]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[125]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[790]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[791]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[792]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[793]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[794]

Drug(s) Affected By Aryl hydrocarbon receptor nuclear translocator (ARNT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[795]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[247]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[796]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[797]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[798]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[421]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[405]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[264]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]

Drug(s) Affected By Calreticulin (CALR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[292]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[408]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[799]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[363]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[800]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[801]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[342]

Drug(s) Affected By Calnexin (CANX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[292]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[351]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[30]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[802]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[200]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[351]

Drug(s) Affected By Glutathione S-transferase Mu 2 (GSTM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[294]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[803]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[804]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[805]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]

Drug(s) Affected By Progranulin (GRN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[806]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[190]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[110]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[322]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]

Drug(s) Affected By Transcription initiation factor IIE subunit beta (GTF2E2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[263]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[263]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[323]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[807]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[772]

Drug(s) Affected By Ephrin type-B receptor 2 (EPHB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[106]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Bortezomib	DMNO38U	Leukemia		Approved	[269]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[341]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[358]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[57]

Drug(s) Affected By AT-rich interactive domain-containing protein 4A (ARID4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[27]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[63]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[676]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[808]

Drug(s) Affected By Nitric oxide synthase 3 (NOS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[809]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[427]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[76]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[810]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[247]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[811]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[812]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[813]
Fructose	DM43AN2	Vomiting	MD90	Approved	[814]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[815]

Drug(s) Affected By Serpin B3 (SERPINB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[150]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[556]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[225]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[301]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[816]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[150]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
EUGENOL	DM7US1H	Discovery agent	N.A.	Patented	[816]

Drug(s) Affected By Leiomodin-1 (LMOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[527]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[368]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[817]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[818]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[386]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[26]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]

Drug(s) Affected By Myristoylated alanine-rich C-kinase substrate (MARCKS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[308]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[308]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[477]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[469]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]

Drug(s) Affected By Thioredoxin-dependent peroxide reductase, mitochondrial (PRDX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[819]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[820]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[620]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[358]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[470]

Drug(s) Affected By Phosphatidylethanolamine-binding protein 1 (PEBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[821]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[663]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[342]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[342]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[822]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]

Drug(s) Affected By G1/S-specific cyclin-D3 (CCND3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[84]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[402]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[387]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[823]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[824]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[825]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[371]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[613]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]

Drug(s) Affected By Coronin-1A (CORO1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[381]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[589]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[826]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[81]

Drug(s) Affected By S-adenosylmethionine synthase isoform type-2 (MAT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[342]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[827]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[828]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[827]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[829]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[830]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[457]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[574]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[831]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[746]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[832]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[511]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[417]

Drug(s) Affected By Bifunctional purine biosynthesis protein ATIC (ATIC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[283]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[653]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[268]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[190]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[110]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]

Drug(s) Affected By Neural cell adhesion molecule L1 (L1CAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[334]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[334]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[833]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[315]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[834]

Drug(s) Affected By Deoxycytidylate deaminase (DCTD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[185]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[355]

Drug(s) Affected By Cystathionine gamma-lyase (CTH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[460]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[351]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[586]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[206]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[460]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[309]

Drug(s) Affected By Large ribosomal subunit protein uL6 (RPL9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[292]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[580]
Nabiximols	DMHKJ5I	Cancer related pain	MG30	Phase 3	[835]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[491]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[714]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]

Drug(s) Affected By Cyclin-dependent kinases regulatory subunit 2 (CKS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[371]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[443]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[159]

Drug(s) Affected By Histone H2B type 1-B (H2BC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[527]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[190]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[110]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[836]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]

Drug(s) Affected By Dual specificity protein kinase TTK (TTK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[84]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[274]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]

Drug(s) Affected By Heat shock 70 kDa protein 4 (HSPA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[837]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[44]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[203]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[507]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[351]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]

Drug(s) Affected By Glypican-1 (GPC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[806]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[817]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[171]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[96]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[248]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[838]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[513]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[525]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[839]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[840]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[841]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[712]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[842]

Drug(s) Affected By Basigin (BSG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[843]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[844]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Carfilzomib	DM48K0X	Multiple myeloma	2A83	Approved	[843]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[845]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[843]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[342]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[460]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[846]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[70]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[243]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[72]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[235]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[847]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[848]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]

Drug(s) Affected By Transcription factor SOX-5 (SOX5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[207]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[250]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[57]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[849]

Drug(s) Affected By Glutaredoxin-1 (GLRX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[235]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[206]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[722]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[250]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]

Drug(s) Affected By Choline kinase alpha (CHKA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[15]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[247]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]

Drug(s) Affected By Vascular endothelial growth factor receptor 2 (KDR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[850]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[851]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[852]
Haloperidol	DM96SE0	Delirium		Approved	[342]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[342]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[63]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[853]

Drug(s) Affected By Large ribosomal subunit protein uL4 (RPL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[411]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[735]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[854]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[580]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[662]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[271]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[27]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[715]

Drug(s) Affected By Phosphoglucomutase-1 (PGM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]

Drug(s) Affected By Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PPP1CC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[177]

Drug(s) Affected By TGF-beta receptor type-2 (TGFBR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[530]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[844]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[387]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[479]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[707]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]

Drug(s) Affected By Alpha-synuclein (SNCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[268]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[188]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Bortezomib	DMNO38U	Leukemia		Approved	[855]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[856]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[263]

Drug(s) Affected By Breast cancer type 1 susceptibility protein (BRCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[317]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[762]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[397]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[487]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[88]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[769]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[237]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]

Drug(s) Affected By DNA-binding protein SMUBP-2 (IGHMBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[247]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[207]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[857]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[177]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[266]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[388]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[529]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[275]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[483]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[235]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[278]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[858]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[551]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[241]

Drug(s) Affected By Large ribosomal subunit protein uL3 (RPL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[247]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[184]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[859]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[580]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[184]

Drug(s) Affected By T-complex protein 1 subunit zeta (CCT6A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[342]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[589]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[735]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[190]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[470]

Drug(s) Affected By ADP-ribosylation factor-like protein 1 (ARL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[529]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[309]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[190]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[171]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[271]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[193]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[860]

Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[76]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[138]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[861]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[862]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[863]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[247]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[864]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[865]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[630]

Drug(s) Affected By DNA-binding protein inhibitor ID-1 (ID1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[866]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[541]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[248]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[174]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[867]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[206]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]

Drug(s) Affected By Eukaryotic translation initiation factor 1 (EIF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[529]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[267]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[309]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[309]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[575]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]

Drug(s) Affected By Signal transducer and activator of transcription 6 (STAT6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[868]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[247]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[869]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[870]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[868]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]

Drug(s) Affected By Glutamate receptor 2 (GRIA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[871]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[556]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[872]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[622]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[26]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[873]
UNC0379	DMD1E4J	Hepatocellular carcinoma	2C12.02	Preclinical	[874]

Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[875]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[876]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[877]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[877]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[875]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[875]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[778]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[878]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]

Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (PIK3CA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[879]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[114]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[880]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[881]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]

Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[882]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[744]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[745]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[883]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[417]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[587]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[884]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[653]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[885]

Drug(s) Affected By Epidermal growth factor receptor substrate 15 (EPS15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[765]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[515]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[184]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[807]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]

Drug(s) Affected By Neuronal vesicle trafficking-associated protein 1 (NSG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[247]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[358]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[314]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[886]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[887]

Drug(s) Affected By Excitatory amino acid transporter 2 (SLC1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[888]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[889]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[205]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Thiamphenicol	DMDRKH2	Bacterial infection	1A00-1C4Z	Approved	[890]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[888]

Drug(s) Affected By Platelet-activating factor acetylhydrolase IB subunit beta (PAFAH1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[161]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[469]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[322]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[891]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[171]

Drug(s) Affected By Translocon-associated protein subunit alpha (SSR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[225]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[190]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[558]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]

Drug(s) Affected By Nuclear receptor subfamily 4 group A member 2 (NR4A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[892]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[334]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[148]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[206]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[783]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[556]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[893]

Drug(s) Affected By Nicotinamide phosphoribosyltransferase (NAMPT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[588]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[894]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[443]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[164]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[309]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[309]

Drug(s) Affected By Neuronal acetylcholine receptor subunit alpha-4 (CHRNA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[177]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Atropine	DMEN6X7	Organophosphate poisoning	NE6Z	Approved	[696]
Galantamine	DMEO794	Alzheimer disease	8A20	Approved	[696]
Rivastigmine	DMG629M	Alzheimer disease	8A20	Approved	[696]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[895]
Scopolamine	DMOM8AL	Addictive disorder	6C50-6C5Z	Approved	[696]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[896]

Drug(s) Affected By Proliferation marker protein Ki-67 (MKI67)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[897]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[27]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[329]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[371]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[898]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[710]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]

Drug(s) Affected By Adapter molecule crk (CRK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[185]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[27]

Drug(s) Affected By Crk-like protein (CRKL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[688]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[899]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[900]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[901]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[270]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[902]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[491]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[903]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[482]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[402]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[858]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[904]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[905]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[404]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[906]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[774]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[907]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[908]

Drug(s) Affected By Large ribosomal subunit protein eL28 (RPL28)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[223]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[358]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[580]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[184]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[909]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[26]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]

Drug(s) Affected By Small ribosomal subunit protein uS7 (RPS5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[411]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[190]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[271]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[910]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[731]

Drug(s) Affected By Microtubule-associated protein 1B (MAP1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[216]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[206]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[667]

Drug(s) Affected By Glucosamine-6-phosphate isomerase 1 (GNPDA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[184]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[224]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[358]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[306]

Drug(s) Affected By Ras GTPase-activating-like protein IQGAP1 (IQGAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[203]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[488]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[911]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[411]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[311]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]

Drug(s) Affected By NADP-dependent malic enzyme (ME1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[422]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[235]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[392]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[563]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[309]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[309]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[435]

Drug(s) Affected By Lanosterol synthase (LSS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[517]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[392]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[517]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[517]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[517]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[61]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[479]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[518]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[517]

Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[422]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[544]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[912]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[392]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[913]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[914]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[915]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[586]

Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[422]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[392]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[916]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[351]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[666]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[563]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[917]

Drug(s) Affected By Nuclear receptor-interacting protein 1 (NRIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[114]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[918]
Teniposide	DMLW57T	Acute lymphoblastic leukaemia	2A85	Approved	[919]

Drug(s) Affected By Casein kinase I isoform alpha (CSNK1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[515]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[322]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]

Drug(s) Affected By Natural resistance-associated macrophage protein 2 (SLC11A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[920]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[301]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[378]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[921]

Drug(s) Affected By Fatty acid synthase (FASN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[922]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[511]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[72]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[923]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[924]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[61]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[925]

Drug(s) Affected By Large ribosomal subunit protein bL19m (MRPL19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Bortezomib	DMNO38U	Leukemia		Approved	[269]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[714]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[273]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[195]

Drug(s) Affected By Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[411]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[722]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[358]

Drug(s) Affected By Centromere protein F (CENPF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[926]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]

Drug(s) Affected By Cysteine--tRNA ligase, cytoplasmic (CARS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[292]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[247]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[204]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[707]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[309]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[309]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[204]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[225]

Drug(s) Affected By Dual specificity protein kinase CLK1 (CLK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[460]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[927]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]

Drug(s) Affected By Placenta growth factor (PGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[205]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[928]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[368]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[264]

Drug(s) Affected By Presenilin-1 (PSEN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[44]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[88]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[929]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[63]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[687]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[373]
Bortezomib	DMNO38U	Leukemia		Approved	[269]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]

Drug(s) Affected By Presenilin-2 (PSEN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[44]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[687]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[188]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[930]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[931]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]

Drug(s) Affected By Isocitrate dehydrogenase subunit alpha, mitochondrial (IDH3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[216]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[932]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[933]
Bortezomib	DMNO38U	Leukemia		Approved	[934]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[934]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[322]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]

Drug(s) Affected By Sulfotransferase 1A1 (SULT1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[358]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[935]
Minoxidil	DMA2Z4F	Alopecia	ED70	Approved	[936]
Benzyl alcohol	DMBVYDI	Head and body lice	1G00.0	Approved	[937]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[936]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[938]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[292]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[939]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]

Drug(s) Affected By ETS translocation variant 1 (ETV1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[940]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[358]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[941]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[184]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[314]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[678]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[678]

Drug(s) Affected By Achaete-scute homolog 1 (ASCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[942]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[264]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[57]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[943]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[944]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[193]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[225]

Drug(s) Affected By Dual specificity protein phosphatase 3 (DUSP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[945]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[263]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[263]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[110]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[224]

Drug(s) Affected By Amyloid beta precursor like protein 1 (APLP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[946]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[22]

Drug(s) Affected By Cyclin-H (CCNH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[947]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[505]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[948]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[364]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[421]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[421]

Drug(s) Affected By Serine/threonine-protein kinase Nek2 (NEK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[274]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[292]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]

Drug(s) Affected By Cyclin-G1 (CCNG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[88]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[443]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[63]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[949]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[110]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[950]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein M (HNRNPM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[408]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[951]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[26]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[271]

Drug(s) Affected By DNA-directed RNA polymerases I, II, and III subunit RPABC3 (POLR2H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[323]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[952]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[270]

Drug(s) Affected By DNA mismatch repair protein Msh6 (MSH6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[84]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[241]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]

Drug(s) Affected By High mobility group protein HMGI-C (HMGA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[529]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[527]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[557]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[341]

Drug(s) Affected By Nuclear pore complex protein Nup98-Nup96 (NUP98)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[301]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[953]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[271]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[27]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[27]

Drug(s) Affected By Geranylgeranyl transferase type-2 subunit beta (RABGGTB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[164]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[323]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[954]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[81]

Drug(s) Affected By Mitogen-activated protein kinase 12 (MAPK12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[216]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[61]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[955]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[956]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[957]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[736]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[57]
Amsacrine	DMZKYIV	Acute lymphoblastic leukaemia	2A85	Approved	[957]

Drug(s) Affected By Ornithine decarboxylase antizyme 1 (OAZ1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[311]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[110]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[185]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[185]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]

Drug(s) Affected By Branched-chain-amino-acid aminotransferase, cytosolic (BCAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[309]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[309]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[309]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]

Drug(s) Affected By Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (PDE1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[958]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[301]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[959]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[315]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[264]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[622]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[171]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[960]

Drug(s) Affected By Caspase-7 (CASP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[642]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[70]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[961]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[962]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[963]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[963]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[88]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[158]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[964]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[602]

Drug(s) Affected By BH3-interacting domain death agonist (BID)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[277]
Selenium	DM25CGV	N. A.	N. A.	Approved	[245]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[965]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[966]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[967]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]

Drug(s) Affected By NADH dehydrogenase flavoprotein 3, mitochondrial (NDUFV3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[216]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[968]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[969]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[970]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]

Drug(s) Affected By P2X purinoceptor 3 (P2RX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
QUERCITRIN	DM1DH96	Discovery agent	N.A.	Investigative	[971]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[180]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[178]

Drug(s) Affected By T-cell leukemia translocation-altered gene protein (TCTA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]

Drug(s) Affected By Claudin-2 (CLDN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[177]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[972]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[666]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[973]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[666]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[210]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[301]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[974]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[975]

Drug(s) Affected By Sestrin-2 (SESN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[460]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[656]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[204]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[351]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[204]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[307]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[460]

Drug(s) Affected By Neurexin-1-beta (NRXN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[177]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[976]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[977]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[449]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[314]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[886]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[177]

Drug(s) Affected By Histone H2B type 1-D (H2BC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[292]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[806]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[222]

Drug(s) Affected By Triosephosphate isomerase (TPI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[408]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[472]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[473]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[978]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[979]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[411]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]

Drug(s) Affected By Synaptosomal-associated protein 25 (SNAP25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[292]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[260]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[734]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[301]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]

Drug(s) Affected By Cyclin-dependent kinases regulatory subunit 1 (CKS1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[774]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[613]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[527]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[980]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]

Drug(s) Affected By C-X-C chemokine receptor type 4 (CXCR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[294]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[308]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[513]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[797]
Carfilzomib	DM48K0X	Multiple myeloma	2A83	Approved	[843]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[308]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[981]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[982]

Drug(s) Affected By Large ribosomal subunit protein uL24 (RPL26)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[958]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Bortezomib	DMNO38U	Leukemia		Approved	[269]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[27]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[366]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[731]

Drug(s) Affected By Somatostatin (SST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[235]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[556]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Octreotide	DMHIDCJ	Acromegaly	5A60.0	Approved	[232]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[368]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[983]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[235]

Drug(s) Affected By 10 kDa heat shock protein, mitochondrial (HSPE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[821]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[412]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[508]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[412]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[583]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[619]

Drug(s) Affected By Syntaxin-binding protein 1 (STXBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[984]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[734]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[445]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[171]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[985]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]

Drug(s) Affected By Beta-2-microglobulin (B2M)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[986]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[292]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[987]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[588]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[988]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[989]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[990]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[740]

Drug(s) Affected By Small ribosomal subunit protein eS7 (RPS7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[177]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[930]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[26]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[271]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[306]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[991]

Drug(s) Affected By Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PPP1CB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[707]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[409]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]

Drug(s) Affected By Small ribosomal subunit protein uS13 (RPS18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[411]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[992]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[185]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[985]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[662]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[366]

Drug(s) Affected By Small ribosomal subunit protein uS15 (RPS13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[411]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[575]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[930]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[662]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[306]
all-trans-4-oxo-retinoic acid	DMM2R1N	Discovery agent	N.A.	Investigative	[153]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[731]

Drug(s) Affected By TATA box-binding protein-like 1 (TBPL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[323]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[731]

Drug(s) Affected By Eukaryotic peptide chain release factor subunit 1 (ETF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[264]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[910]

Drug(s) Affected By Rho-related GTP-binding protein RhoB (RHOB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[153]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[163]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[443]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[155]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[993]

Drug(s) Affected By Small ribosomal subunit protein eS6 (RPS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[994]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[247]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[995]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[749]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[469]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[996]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[997]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[596]
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[829]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]

Drug(s) Affected By Small ribosomal subunit protein eS25 (RPS25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[250]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[580]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[217]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[985]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[217]

Drug(s) Affected By E3 ubiquitin-protein ligase RBX1 (RBX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[443]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[594]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[930]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[323]

Drug(s) Affected By Large ribosomal subunit protein uL5 (RPL11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[342]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[271]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[177]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[998]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[731]
[3H]methyltrienolone	DMTSGOW	Discovery agent	N.A.	Investigative	[999]

Drug(s) Affected By Large ribosomal subunit protein uL2 (RPL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[619]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[580]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[271]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[177]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[998]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[731]

Drug(s) Affected By Ras-related C3 botulinum toxin substrate 1 (RAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[372]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1000]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[163]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[613]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[1000]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[575]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[478]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[594]

Drug(s) Affected By S-phase kinase-associated protein 1 (SKP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[342]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[594]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[322]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[1001]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[184]

Drug(s) Affected By Histone H3.1 (H3C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[317]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[148]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[307]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]

Drug(s) Affected By Hemoglobin subunit alpha (HBA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[488]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[207]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[311]
Flucloxacillin	DMNUWST	Bacterial infection	1A00-1C4Z	Approved	[1002]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[736]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[1003]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[110]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[1004]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[315]

Drug(s) Affected By Disintegrin and metalloproteinase domain-containing protein 8 (ADAM8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[247]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[223]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[1005]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[177]

Drug(s) Affected By RNA-binding protein 6 (RBM6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[358]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[271]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[27]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[27]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[368]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[354]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[265]

Drug(s) Affected By Phosphatidylinositol 5-phosphate 4-kinase type-2 beta (PIP4K2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[292]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[184]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[468]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[954]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[171]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[316]

Drug(s) Affected By Reelin (RELN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[1006]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[1007]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[315]

Drug(s) Affected By DNA-dependent protein kinase catalytic subunit (PRKDC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[203]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[292]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[513]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[351]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1008]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[679]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]

Drug(s) Affected By Small ribosomal subunit protein bS6m (MRPS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[305]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[323]

Drug(s) Affected By Mothers against decapentaplegic homolog 3 (SMAD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[177]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1009]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1010]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1011]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1012]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[567]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[261]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[301]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[1013]

Drug(s) Affected By Rho GTPase-activating protein 8 (ARHGAP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[207]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[358]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[691]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[26]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[376]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[1014]

Drug(s) Affected By Forkhead box protein O4 (FOXO4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[188]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[468]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[1015]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[263]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[190]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[264]

Drug(s) Affected By Cytochrome c (CYCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[1016]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[548]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[1017]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1018]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[962]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1019]
Pefloxacin	DM49IGF	Gonococcal urethritis	1A70.0Y	Approved	[1020]

Drug(s) Affected By Phosphatidylinositol transfer protein alpha isoform (PITPNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[247]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[26]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[1014]

Drug(s) Affected By Cyclin-dependent kinase 6 (CDK6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[606]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[459]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[45]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[484]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[247]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[823]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]

Drug(s) Affected By Cyclin-dependent kinase 5 (CDK5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[529]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[48]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1021]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[371]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[980]

Drug(s) Affected By Clathrin heavy chain 1 (CLTC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[184]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[735]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[854]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[389]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[184]

Drug(s) Affected By E3 ubiquitin-protein ligase Mdm2 (MDM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Flucytosine	DM13VTW	Cryptococcal meningitis		Approved	[1022]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[1022]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1023]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[88]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1024]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[453]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[351]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[1025]

Drug(s) Affected By Transcription factor E2F1 (E2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1026]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[317]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[773]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[228]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[241]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[484]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]

Drug(s) Affected By Interferon-induced transmembrane protein 3 (IFITM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[247]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[1027]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[856]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]

Drug(s) Affected By Interferon-induced transmembrane protein 2 (IFITM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[247]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[263]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[263]

Drug(s) Affected By Large neutral amino acids transporter small subunit 1 (SLC7A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[561]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[248]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[174]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[516]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[666]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[561]

Drug(s) Affected By ATP-dependent 6-phosphofructokinase, platelet type (PFKP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[177]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[924]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[469]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[1028]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[264]

Drug(s) Affected By DNA-binding protein SATB1 (SATB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[177]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1029]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[206]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[188]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[617]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[190]

Drug(s) Affected By POU domain, class 4, transcription factor 1 (POU4F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[247]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[443]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[1030]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[57]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[184]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[314]

Drug(s) Affected By Sodium-dependent dopamine transporter (SLC6A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[1031]
Amphetamine	DMSZQAK	Attention deficit hyperactivity disorder	6A05.Z	Approved	[1032]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[1033]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[1034]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Dextroamphetamine	DMMIHVP	Attention deficit hyperactivity disorder	6A05.Z	Approved	[1035]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[171]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[1036]

Drug(s) Affected By 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (PLCB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[27]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[715]

Drug(s) Affected By Transgelin (TAGLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[517]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[652]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[1037]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[517]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[667]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[517]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[517]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1038]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[1037]

Drug(s) Affected By Kinesin-like protein KIF23 (KIF23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[15]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[1039]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[24]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1040]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1041]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[1042]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[154]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[234]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[1043]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[63]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase FKBP4 (FKBP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[216]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[247]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[356]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]

Drug(s) Affected By Peroxisome proliferator-activated receptor delta (PPARD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[422]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1044]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1045]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[206]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[1046]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[1047]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[574]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[487]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1048]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[1049]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1050]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[1051]

Drug(s) Affected By Keratin, type I cytoskeletal 17 (KRT17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[1052]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[145]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[153]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[1052]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[153]

Drug(s) Affected By Neurogenic locus notch homolog protein 2 (NOTCH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[576]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[1053]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[687]
Bortezomib	DMNO38U	Leukemia		Approved	[269]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[264]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[941]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[184]

Drug(s) Affected By Proteolipid protein 2 (PLP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[954]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[185]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[185]

Drug(s) Affected By Dynamin-1 (DNM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[171]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[359]

Drug(s) Affected By Focal adhesion kinase 1 (PTK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[790]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1054]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[152]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1055]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[1056]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[1057]
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[1058]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]

Drug(s) Affected By GA-binding protein subunit beta-1 (GABPB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[984]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[263]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[263]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[984]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[150]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[1059]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[568]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[43]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[317]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[572]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[294]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[1017]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[483]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[248]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[1060]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[551]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[457]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1061]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[277]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1062]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[88]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[1022]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[298]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]

Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[124]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[294]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[1063]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[296]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[1064]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[513]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[131]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[294]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[1065]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[300]

Drug(s) Affected By Lysyl oxidase homolog 1 (LOXL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[356]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1066]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[713]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[184]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[171]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[1067]

Drug(s) Affected By Histone acetyltransferase p300 (EP300)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1010]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1068]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[567]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[63]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[687]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[968]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]

Drug(s) Affected By Secernin-1 (SCRN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[480]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[263]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[315]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[718]

Drug(s) Affected By POU domain, class 4, transcription factor 2 (POU4F2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[171]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[171]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[1069]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[271]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]

Drug(s) Affected By Follistatin-related protein 1 (FSTL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[479]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[301]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[954]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[358]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]

Drug(s) Affected By Contactin-1 (CNTN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[148]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Mecamylamine	DMGQFYB	Essential hypertension	BA00	Approved	[1070]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[1070]

Drug(s) Affected By Interferon-related developmental regulator 2 (IFRD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Bortezomib	DMNO38U	Leukemia		Approved	[269]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[264]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[176]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[270]

Drug(s) Affected By Ral guanine nucleotide dissociation stimulator (RALGDS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[184]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[617]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[190]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[171]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[359]

Drug(s) Affected By Protein AF1q (MLLT11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[768]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[339]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[184]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[301]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Bortezomib	DMNO38U	Leukemia		Approved	[269]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[1071]

Drug(s) Affected By Dual specificity protein phosphatase 4 (DUSP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[317]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[563]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]

Drug(s) Affected By E3 ubiquitin-protein ligase CBL-B (CBLB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[247]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[63]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[315]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[252]

Drug(s) Affected By Steroidogenic factor 1 (NR5A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1072]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[1073]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[1074]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1075]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[1076]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[1077]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
27-hydroxycholesterol	DM2L6OZ	Discovery agent	N.A.	Investigative	[1078]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[1079]

Drug(s) Affected By Serine-protein kinase ATM (ATM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[1080]
Paromomycin	DM1AGXN	Amoebiasis	1A36	Approved	[1081]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[397]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[278]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[513]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[329]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[351]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[132]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1082]

Drug(s) Affected By Growth factor receptor-bound protein 10 (GRB10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[177]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[253]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1083]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[206]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]

Drug(s) Affected By DNA-binding protein Ikaros (IKZF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Bortezomib	DMNO38U	Leukemia		Approved	[269]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[315]
Vitamin C	DMXJ7O8	Adenocarcinoma	2D40	Approved	[1084]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[81]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[195]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[167]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[744]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1085]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[1086]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[253]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[88]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]

Drug(s) Affected By Serine/threonine-protein kinase ATR (ATR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[351]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[1087]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1088]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[955]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[679]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[351]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[1089]

Drug(s) Affected By Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1090]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[417]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[609]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1083]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1091]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[206]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[997]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[756]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[268]

Drug(s) Affected By Calcium/calmodulin-dependent protein kinase type II subunit beta (CAMK2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[44]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[164]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[679]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[1092]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[1093]

Drug(s) Affected By Neurogenic differentiation factor 1 (NEUROD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1094]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[1095]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[304]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[184]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]

Drug(s) Affected By Ras-related protein Rab-31 (RAB31)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[309]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[309]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[309]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]

Drug(s) Affected By Laminin subunit gamma-2 (LAMC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[84]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[1096]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[768]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1097]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[768]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[363]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[320]

Drug(s) Affected By Calcyphosin (CAPS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[381]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[188]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[741]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[264]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[930]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]

Drug(s) Affected By Kelch-like ECH-associated protein 1 (KEAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1098]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[15]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[56]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1099]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[309]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[309]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[309]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[411]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[984]

Drug(s) Affected By Transcription factor Dp-1 (TFDP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[84]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[371]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[331]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[63]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[722]

Drug(s) Affected By Large ribosomal subunit protein mL62 (MRPL58)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[292]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[306]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[180]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[195]
1,6-hexamethylene diisocyanate	DMLB3RT	Discovery agent	N.A.	Investigative	[1100]

Drug(s) Affected By Protein BTG3 (BTG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[241]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[371]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[241]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[364]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[241]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[241]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[1101]

Drug(s) Affected By Src substrate cortactin (CTTN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[151]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[309]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[309]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[309]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]

Drug(s) Affected By Endonuclease G, mitochondrial (ENDOG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[292]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[367]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[679]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[501]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[421]

Drug(s) Affected By UDP-glucose 4-epimerase (GALE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[589]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[160]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]

Drug(s) Affected By Polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[315]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[184]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[185]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[185]

Drug(s) Affected By Growth factor receptor-bound protein 14 (GRB14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[225]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[301]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[722]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1102]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[675]

Drug(s) Affected By Transcription factor HES-1 (HES1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1103]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[164]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]

Drug(s) Affected By Histone RNA hairpin-binding protein (SLBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[177]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[292]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[241]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[241]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[722]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[241]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[241]

Drug(s) Affected By Endoplasmic reticulum membrane sensor NFE2L1 (NFE2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[248]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[253]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[184]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[854]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[1104]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[322]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[1105]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[358]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1106]

Drug(s) Affected By Inositol 1,4,5-trisphosphate receptor type 2 (ITPR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[177]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1107]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]

Drug(s) Affected By Indian hedgehog protein (IHH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[177]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[1108]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[1109]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[1109]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
CHIR-99021	DMB8MNU	Allergic inflammation	4A80-4A85	Patented	[1110]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[1111]

Drug(s) Affected By Plastin-1 (PLS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[268]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[373]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[322]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]

Drug(s) Affected By Structural maintenance of chromosomes protein 1A (SMC1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[84]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1112]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[844]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[1112]
Bortezomib	DMNO38U	Leukemia		Approved	[269]

Drug(s) Affected By Ribosomal RNA processing protein 1 homolog B (RRP1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[930]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[886]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[27]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[27]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[1113]

Drug(s) Affected By Membrane-bound transcription factor site-1 protease (MBTPS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[27]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[368]

Drug(s) Affected By Major facilitator superfamily domain-containing protein 10 (MFSD10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[588]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[190]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[358]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[891]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[176]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]

Drug(s) Affected By Signal transducer and activator of transcription 4 (STAT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[54]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[308]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[57]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[223]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[308]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[308]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[308]

Drug(s) Affected By Metabotropic glutamate receptor 4 (GRM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[1114]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
PMID20638279C11	DMFHS4V	Discovery agent	N.A.	Investigative	[1115]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[177]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[1116]
2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE	DMNQL17	Discovery agent	N.A.	Investigative	[1117]
4-[1-(4-hydroxyphenyl)-2-phenylbut-1-enyl]phenol	DMTMLXU	Discovery agent	N.A.	Investigative	[1114]

Drug(s) Affected By Nucleolar and coiled-body phosphoprotein 1 (NOLC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[174]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[110]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[322]

Drug(s) Affected By HUWE1-associated protein modifying stress responses 1 (HAPSTR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[930]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[1118]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[271]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[1119]

Drug(s) Affected By Condensin complex subunit 2 (NCAPH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[203]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[104]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Haloperidol	DM96SE0	Delirium		Approved	[342]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[1120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]

Drug(s) Affected By Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (HERPUD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[460]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[70]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[437]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[32]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[783]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[1120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Racecadotril	DMFOTZ7	Diarrhea	ME05.1	Approved	[1121]

Drug(s) Affected By Translocating chain-associated membrane protein 2 (TRAM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1066]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[184]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[171]

Drug(s) Affected By Ribosome biogenesis regulatory protein homolog (RRS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[363]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[190]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[930]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[305]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[984]

Drug(s) Affected By Bromodomain-containing protein 3 (BRD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[184]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[81]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[1122]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[1123]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[271]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]

Drug(s) Affected By Mitochondrial inner membrane protein OXA1L (OXA1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[358]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[193]

Drug(s) Affected By Early endosome antigen 1 (EEA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[57]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[1124]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[171]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]

Drug(s) Affected By Cyclin-dependent kinase 5 activator 1 (CDK5R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[44]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1055]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[340]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[340]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[927]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[1125]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[264]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[1125]

Drug(s) Affected By Platelet-activating factor acetylhydrolase IB subunit alpha1 (PAFAH1B3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[368]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]

Drug(s) Affected By kinase isozyme 1, mitochondrial (PDK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[309]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[309]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[1126]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1127]

Drug(s) Affected By Mitochondrial import receptor subunit TOM20 homolog (TOMM20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[184]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[903]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[27]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[1128]

Drug(s) Affected By Disks large-associated protein 5 (DLGAP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[15]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[309]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[309]

Drug(s) Affected By Transcription initiation factor TFIID subunit 7 (TAF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[27]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[356]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[184]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[205]

Drug(s) Affected By ELAV-like protein 1 (ELAVL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1129]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[1130]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[268]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[1130]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[1131]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Amsacrine	DMZKYIV	Acute lymphoblastic leukaemia	2A85	Approved	[1132]

Drug(s) Affected By Mitochondrial import receptor subunit TOM34 (TOMM34)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[342]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[184]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[342]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[193]

Drug(s) Affected By Neuronal pentraxin-1 (NPTX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[652]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[363]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Bortezomib	DMNO38U	Leukemia		Approved	[269]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[263]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[264]

Drug(s) Affected By ATP-sensitive inward rectifier potassium channel 8 (KCNJ8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Glibenclamide	DM8JXPZ	Diabetic complication	5A2Y	Approved	[1133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[856]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[263]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[358]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1066]

Drug(s) Affected By Alpha-internexin (INA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[292]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[930]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[171]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[622]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[314]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[1134]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[302]

Drug(s) Affected By Synaptophysin-like protein 1 (SYPL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[273]

Drug(s) Affected By Transcription initiation factor TFIID subunit 9 (TAF9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[203]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[203]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[203]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[376]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[271]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[27]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[772]

Drug(s) Affected By Bcl-2 homologous antagonist/killer (BAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[1135]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[248]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1136]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[88]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[1138]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[505]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1139]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[1140]

Drug(s) Affected By C-C motif chemokine 15 (CCL15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[722]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[358]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[22]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]

Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[1141]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1142]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[1143]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[1143]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1144]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1145]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[1146]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[513]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[1147]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[748]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 3 (CDKN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[84]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[205]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]

Drug(s) Affected By Thiosulfate sulfurtransferase (TST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[184]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[368]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[110]

Drug(s) Affected By 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[351]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1148]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[309]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[309]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[261]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[351]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[301]

Drug(s) Affected By Tectonic-1 (TCTN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[184]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[323]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[26]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[903]

Drug(s) Affected By MORN repeat-containing protein 2 (MORN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[930]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[179]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[180]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[195]

Drug(s) Affected By Centrosomal protein of 55 kDa (CEP55)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[184]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[320]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1149]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[301]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[722]

Drug(s) Affected By Interferon-induced protein 44-like (IFI44L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[308]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[308]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[206]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[363]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[57]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]

Drug(s) Affected By Shugoshin 2 (SGO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]

Drug(s) Affected By Protein sidekick-2 (SDK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[190]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[264]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[359]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[225]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[1150]

Drug(s) Affected By APC membrane recruitment protein 1 (AMER1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[190]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[930]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[171]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[376]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[27]

Drug(s) Affected By Cytochrome c oxidase assembly factor 6 homolog (COA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[560]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[1151]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[180]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[178]

Drug(s) Affected By Breast cancer metastasis-suppressor 1-like protein (BRMS1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[171]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[271]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[886]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[195]

Drug(s) Affected By Protein FAM72A (FAM72A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[1152]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[306]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[57]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[178]

Drug(s) Affected By F-actin-uncapping protein LRRC16A (CARMIL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[622]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[76]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[214]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[27]

Drug(s) Affected By TBC1 domain family member 9B (TBC1D9B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[110]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[316]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[27]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[27]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[368]

Drug(s) Affected By Olfactomedin-like protein 2B (OLFML2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[308]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[308]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[308]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[308]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[818]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[314]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[177]

Drug(s) Affected By Histone H2A type 2-A (H2AC18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[307]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[301]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[954]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[110]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]

Drug(s) Affected By Speckle-type POZ protein-like (SPOPL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[184]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[373]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[886]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[177]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[180]

Drug(s) Affected By Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6 (JMJD6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[322]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[186]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[1118]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[176]

Drug(s) Affected By Transmembrane protein 65 (TMEM65)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[580]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[386]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[184]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[195]

Drug(s) Affected By Biogenesis of lysosome-related organelles complex 1 subunit 2 (BLOC1S2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[529]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[341]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]

Drug(s) Affected By Kelch-like protein 24 (KLHL24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[204]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[159]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[204]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]

Drug(s) Affected By All-trans retinoic acid-induced differentiation factor (ATRAID)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[176]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[731]

Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase-interacting protein (IKBIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[1153]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[1154]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[930]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[171]

Drug(s) Affected By Centromere protein U (CENPU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[184]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[188]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[527]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]

Drug(s) Affected By Histone H2A.V (H2AZ2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[311]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[722]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[817]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[184]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[185]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[1155]

Drug(s) Affected By eIF5-mimic protein 2 (BZW1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[154]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[30]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[342]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[817]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[306]

Drug(s) Affected By BTB/POZ domain-containing protein KCTD9 (KCTD9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[250]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[323]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[186]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[662]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[306]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[270]

Drug(s) Affected By FAST kinase domain-containing protein 5, mitochondrial (FASTKD5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[323]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[354]
RESORCINOL	DMM37C0	Discovery agent	N.A.	Investigative	[722]

Drug(s) Affected By Sprouty-related, EVH1 domain-containing protein 2 (SPRED2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[270]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[184]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[271]

Drug(s) Affected By Dehydrodolichyl diphosphate synthase complex subunit DHDDS (DHDDS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
GW7647	DM9RD0C	Discovery agent	N.A.	Investigative	[1156]

Drug(s) Affected By Retrotransposon-derived protein PEG10 (PEG10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[479]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[310]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[164]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[583]

Drug(s) Affected By Kinectin (KTN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[469]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[342]
Bortezomib	DMNO38U	Leukemia		Approved	[269]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[270]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[580]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[26]

Drug(s) Affected By Poly(ADP-ribose) glycohydrolase (PARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[27]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[358]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]

Drug(s) Affected By C2 domain-containing protein 5 (C2CD5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[110]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]

Drug(s) Affected By CREB3 regulatory factor (CREBRF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[783]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[515]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[164]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[188]

Drug(s) Affected By NudC domain-containing protein 3 (NUDCD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[247]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[1157]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]

Drug(s) Affected By Extracellular sulfatase Sulf-1 (SULF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[563]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[527]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[368]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[1158]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]

Drug(s) Affected By RNA-binding protein 12B (RBM12B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[271]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[27]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[27]

Drug(s) Affected By Solute carrier family 35 member F2 (SLC35F2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[516]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[264]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]

Drug(s) Affected By ATP-dependent RNA helicase SUPV3L1, mitochondrial (SUPV3L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[184]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[940]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[323]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[677]

Drug(s) Affected By Synaptotagmin-like protein 1 (SYTL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1127]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[358]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[264]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[1159]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[171]

Drug(s) Affected By ELMO domain-containing protein 1 (ELMOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[148]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[206]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[314]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[57]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[57]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]

Drug(s) Affected By Activating signal cointegrator 1 complex subunit 3 (ASCC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[930]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[171]

Drug(s) Affected By GTP-binding protein 8 (GTPBP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[368]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[250]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[26]

Drug(s) Affected By Inactive dipeptidyl peptidase 10 (DPP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[177]

Drug(s) Affected By Phospholipid-transporting ATPase IG (ATP11C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[184]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[373]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[263]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[263]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[930]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[148]

Drug(s) Affected By Estradiol 17-beta-dehydrogenase 11 (HSD17B11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[110]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]

Drug(s) Affected By Arrestin domain-containing protein 4 (ARRDC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[114]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[583]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[3]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[16]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[301]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]

Drug(s) Affected By MAPK-interacting and spindle-stabilizing protein-like (MAPK1IP1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[927]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[27]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[177]

Drug(s) Affected By ATP-binding cassette sub-family F member 1 (ABCF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[889]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[184]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[27]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[27]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[177]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[270]
Hexadecanoic acid	DMWUXDZ	Discovery agent	N.A.	Investigative	[1160]

Drug(s) Affected By Transient receptor potential cation channel subfamily V member 1 (TRPV1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[1161]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1162]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[222]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[1163]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[1164]
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[1165]

Drug(s) Affected By Neuron navigator 1 (NAV1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[301]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[368]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[341]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[358]

Drug(s) Affected By Transmembrane protein 185A (TMEM185A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[378]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[314]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[180]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[195]

Drug(s) Affected By Kinetochore scaffold 1 (KNL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]

Drug(s) Affected By Fin bud initiation factor homolog (FIBIN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[206]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[57]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[1005]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[177]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[180]

Drug(s) Affected By Endonuclease 8-like 3 (NEIL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[84]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[207]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[190]

Drug(s) Affected By Gasdermin-B (GSDMB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[190]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[264]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[184]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[1005]

Drug(s) Affected By Proline-rich protein 7 (PRR7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[381]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Bortezomib	DMNO38U	Leukemia		Approved	[269]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[214]

Drug(s) Affected By Membrane protein FAM174A (FAM174A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[177]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[195]
bilirubin	DMI0V4O	Discovery agent	N.A.	Investigative	[1166]

Drug(s) Affected By Protein kish-A (TMEM167A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[1167]

Drug(s) Affected By Interferon-induced protein 44 (IFI44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[308]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[308]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[206]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[556]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[1168]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[308]
Bortezomib	DMNO38U	Leukemia		Approved	[269]

Drug(s) Affected By Apoptosis-enhancing nuclease (AEN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[307]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[927]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[930]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]

Drug(s) Affected By DEP domain-containing protein 1B (DEPDC1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[320]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[527]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[722]

Drug(s) Affected By Pleckstrin homology-like domain family A member 1 (PHLDA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[317]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[206]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[159]

Drug(s) Affected By Soluble calcium-activated nucleotidase 1 (CANT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[269]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[468]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[1169]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[270]

Drug(s) Affected By Reticulon-4-interacting protein 1, mitochondrial (RTN4IP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[358]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[171]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[323]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]

Drug(s) Affected By (3R)-3-hydroxyacyl-CoA dehydrogenase (HSD17B8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[268]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[1170]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[358]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]

Drug(s) Affected By Polyphosphoinositide phosphatase (FIG4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[184]

Drug(s) Affected By Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[561]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[328]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[561]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Mestranol	DMG3F94	Contraception	QA21	Approved	[561]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[561]

Drug(s) Affected By Protein NDRG1 (NDRG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[644]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[1171]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[487]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[924]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[268]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[188]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]

Drug(s) Affected By Secreted frizzled-related protein 3 (FRZB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[661]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[661]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[222]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[311]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[188]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[368]

Drug(s) Affected By Histone acetyltransferase KAT6A (KAT6A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[177]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[190]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[1172]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[27]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[148]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[27]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[177]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[270]

Drug(s) Affected By Neuronal cell adhesion molecule (NRCAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[177]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[292]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[988]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[301]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[368]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[1173]

Drug(s) Affected By Bcl-2-like protein 2 (BCL2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[140]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1174]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1175]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[508]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[63]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[1176]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[1177]

Drug(s) Affected By COP9 signalosome complex subunit 5 (COPS5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1178]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[271]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[306]

Drug(s) Affected By SWI/SNF complex subunit SMARCC1 (SMARCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[459]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[268]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[190]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[378]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[353]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[81]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[26]

Drug(s) Affected By Rho guanine nucleotide exchange factor 2 (ARHGEF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[151]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[174]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[206]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Mebendazole	DMO14SG	Ascariasis	1F62	Approved	[1179]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[421]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[263]

Drug(s) Affected By Histone H2A type 1-C (H2AC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[443]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[301]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[676]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[503]

Drug(s) Affected By Ribonuclease P/MRP protein subunit POP5 (POP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[164]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[268]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[368]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[171]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[323]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]

Drug(s) Affected By Mitochondrial calcium uniporter regulator 1 (MCUR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[184]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[301]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[184]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[1128]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[180]

Drug(s) Affected By Exosome complex component RRP43 (EXOSC8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[110]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[1152]

Drug(s) Affected By Spindle and kinetochore-associated protein 1 (SKA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[527]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[722]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[190]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]

Drug(s) Affected By AP-2 complex subunit mu (AP2M1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Haloperidol	DM96SE0	Delirium		Approved	[342]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[575]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[323]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[26]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]

Drug(s) Affected By RNA-binding protein Musashi homolog 2 (MSI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[164]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]

Drug(s) Affected By Arylsulfatase G (ARSG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[356]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[186]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[176]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]

Drug(s) Affected By ERO1-like protein alpha (ERO1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[309]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[410]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[309]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[301]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]

Drug(s) Affected By Proline-rich protein 11 (PRR11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[363]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[207]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[320]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[527]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]

Drug(s) Affected By Secreted frizzled-related protein 2 (SFRP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[368]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[1180]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[621]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[622]

Drug(s) Affected By Microtubule-associated protein 6 (MAP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[222]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[171]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[314]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[57]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[225]

Drug(s) Affected By Lymphokine-activated killer T-cell-originated protein kinase (PBK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[1181]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]

Drug(s) Affected By Beta-1,3-galactosyltransferase 6 (B3GALT6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[292]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[110]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[184]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[953]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]

Drug(s) Affected By Bcl-2-modifying factor (BMF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[381]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[340]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[586]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[332]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[309]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[567]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[479]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[63]

Drug(s) Affected By RNA-binding region-containing protein 3 (RNPC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[27]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[27]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[1128]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[57]

Drug(s) Affected By Hippocampus abundant transcript 1 protein (MFSD14A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[164]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[180]

Drug(s) Affected By SLIT and NTRK-like protein 1 (SLITRK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[315]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[171]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[184]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[171]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[177]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[225]

Drug(s) Affected By Hedgehog-interacting protein (HHIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[1182]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[741]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[1183]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[184]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[1184]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[302]

Drug(s) Affected By Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 (MAGI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[114]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[421]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[940]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]

Drug(s) Affected By Sperm-associated antigen 5 (SPAG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]

Drug(s) Affected By Tribbles homolog 3 (TRIB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[460]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[479]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[381]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[204]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[351]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[666]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[204]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[206]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[783]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]

Drug(s) Affected By Tribbles homolog 1 (TRIB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[317]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[247]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[206]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[114]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]

Drug(s) Affected By Protein cramped-like (CRAMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[207]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[190]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[27]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[177]

Drug(s) Affected By Cysteine/serine-rich nuclear protein 1 (CSRNP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[463]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[468]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]

Drug(s) Affected By 2-aminoethanethiol dioxygenase (ADO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[177]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[260]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[264]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[195]

Drug(s) Affected By Legumain (LGMN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[563]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[314]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[302]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[177]

Drug(s) Affected By Perilipin-2 (PLIN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[362]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[479]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[174]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[309]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[1185]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]

Drug(s) Affected By Nuclear pore complex protein Nup88 (NUP88)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[27]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[322]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[185]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]

Drug(s) Affected By TSC22 domain family protein 3 (TSC22D3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[1186]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[174]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[460]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[184]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[1187]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[269]

Drug(s) Affected By Selenide, water dikinase 2 (SEPHS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[263]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[190]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[110]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1188]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[185]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[1189]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[205]

Drug(s) Affected By Cell cycle checkpoint control protein RAD9A (RAD9A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1190]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[1191]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[713]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[1111]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[27]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[1192]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[1193]
taurine	DMVW7N3	Discovery agent	N.A.	Investigative	[1194]

Drug(s) Affected By Kinesin-like protein KIF2C (KIF2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1195]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[320]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]

Drug(s) Affected By Mothers against decapentaplegic homolog 5 (SMAD5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[1071]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[1095]

Drug(s) Affected By Cell division control protein 6 homolog (CDC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[84]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[241]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1190]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]

Drug(s) Affected By Tumor susceptibility gene 101 protein (TSG101)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[177]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[1196]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[1197]
4-hydroxy-2-nonenal	DM2LJFZ	Discovery agent	N.A.	Investigative	[248]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[177]

Drug(s) Affected By Probable rRNA-processing protein EBP2 (EBNA1BP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[174]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[363]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[190]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[110]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[322]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[952]

Drug(s) Affected By Histone H2B type 1-N (H2BC15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[1198]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[110]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[315]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[1199]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[985]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[306]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[266]

Drug(s) Affected By Histone H2B type 1-M (H2BC14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[177]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[247]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[261]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[527]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[1198]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[264]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[1152]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[1199]

Drug(s) Affected By Growth/differentiation factor 15 (GDF15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[460]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[235]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[241]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[253]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1200]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[153]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[153]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1201]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[613]

Drug(s) Affected By Protein CMSS1 (CMSS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[250]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[341]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[361]

Drug(s) Affected By Dysbindin domain-containing protein 2 (DBNDD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[556]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[263]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[313]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[314]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[185]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[909]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[376]

Drug(s) Affected By Rho GTPase-activating protein 9 (ARHGAP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[373]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[263]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[263]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[57]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[176]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[1202]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]
CHOLINE	DM5D9YK	Insomnia	7A00-7A0Z	Investigative	[1203]

Drug(s) Affected By DNA replication complex GINS protein PSF3 (GINS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[188]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[722]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]

Drug(s) Affected By Centromere protein K (CENPK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[527]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[722]

Drug(s) Affected By UDP-sugar transporter protein SLC35A5 (SLC35A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[27]

Drug(s) Affected By Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[460]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[204]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1204]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1205]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[460]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[1120]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[1204]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Racecadotril	DMFOTZ7	Diarrhea	ME05.1	Approved	[1121]

Drug(s) Affected By Nuclear pore complex protein Nup85 (NUP85)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[322]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[857]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[27]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[306]

Drug(s) Affected By Tubulin polymerization-promoting protein family member 3 (TPPP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[556]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[315]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[314]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[1206]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[1207]

Drug(s) Affected By ADP-ribose pyrophosphatase, mitochondrial (NUDT9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Magnesium	DMU4ORS	Ischemic stroke	8B11.5Z	Approved	[1208]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Manganese	DMKT129	N. A.	N. A.	Investigative	[1208]

Drug(s) Affected By Meiotic nuclear division protein 1 homolog (MND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[588]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[148]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[527]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[722]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]

Drug(s) Affected By TM2 domain-containing protein 2 (TM2D2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Bortezomib	DMNO38U	Leukemia		Approved	[269]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[341]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[306]

Drug(s) Affected By Bcl-2-like protein 13 (BCL2L13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[556]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[1158]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
Duvelisib	DM7USVA	Follicular lymphoma	2A80	Phase 2 Trial	[1209]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[27]

Drug(s) Affected By Serine/threonine-protein kinase PINK1, mitochondrial (PINK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[198]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[898]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[898]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1210]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[1211]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[1212]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[1213]

Drug(s) Affected By Kinetochore protein Nuf2 (NUF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[529]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[292]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]

Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[744]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[883]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[88]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1214]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[32]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[1215]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[595]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[1216]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[885]

Drug(s) Affected By Sentrin-specific protease 6 (SENP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[1217]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[735]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[984]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[1217]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[271]

Drug(s) Affected By Superkiller complex protein 8 (SKIC8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[171]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[185]

Drug(s) Affected By Mucolipin-1 (MCOLN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[292]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[306]

Drug(s) Affected By Transmembrane protein 126A (TMEM126A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[184]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[184]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[857]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[180]
AM251	DMTAWHL	Discovery agent	N.A.	Investigative	[1218]

Drug(s) Affected By Polyadenylate-binding protein-interacting protein 1 (PAIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[248]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[1219]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[1219]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1219]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[1219]

Drug(s) Affected By DNA replication factor Cdt1 (CDT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[317]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]

Drug(s) Affected By SH3 domain-binding glutamic acid-rich-like protein 3 (SH3BGRL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[110]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[185]

Drug(s) Affected By 2-aminomuconic semialdehyde dehydrogenase (ALDH8A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1121]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[204]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Racecadotril	DMFOTZ7	Diarrhea	ME05.1	Approved	[1121]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[479]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[942]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[301]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[722]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[959]

Drug(s) Affected By Sodium-coupled neutral amino acid symporter 1 (SLC38A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[177]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1107]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[207]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[190]

Drug(s) Affected By Frizzled-8 (FZD8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1029]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[1220]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[445]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[184]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[1221]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[57]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]

Drug(s) Affected By E3 ubiquitin ligase RNF121 (RNF121)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[309]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[309]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[309]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[309]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[177]

Drug(s) Affected By Ethanolamine kinase 1 (ETNK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[57]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[57]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[1222]

Drug(s) Affected By Transmembrane 9 superfamily member 3 (TM9SF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[366]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[195]

Drug(s) Affected By Exosome complex component RRP41 (EXOSC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[342]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[443]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[363]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[342]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]

Drug(s) Affected By Semaphorin-4B (SEMA4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[252]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]

Drug(s) Affected By Anillin (ANLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[1120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[320]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]

Drug(s) Affected By Neural proliferation differentiation and control protein 1 (NPDC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[322]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[171]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[176]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]

Drug(s) Affected By Delta-like protein 4 (DLL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1223]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[1224]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[1225]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[376]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[903]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[1226]

Drug(s) Affected By Cytochrome P450 26B1 (CYP26B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[1227]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[222]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[1228]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[741]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[263]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1066]

Drug(s) Affected By DNA polymerase epsilon subunit 3 (POLE3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[84]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[958]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[421]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[322]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[421]

Drug(s) Affected By Lymphoid-specific helicase (HELLS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[527]

Drug(s) Affected By Kinesin-like protein KIF15 (KIF15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[15]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[320]

Drug(s) Affected By Homer protein homolog 2 (HOMER2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[653]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[314]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[186]

Drug(s) Affected By FIGNL1-interacting regulator of recombination and mitosis (FIRRM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[527]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[722]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[184]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[1229]

Drug(s) Affected By Ubiquitin-like-conjugating enzyme ATG3 (ATG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1214]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[1219]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[1216]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[1230]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[1219]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[1231]

Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[794]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[585]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1129]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[585]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[1232]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[1129]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1233]

Drug(s) Affected By Structural maintenance of chromosomes protein 4 (SMC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[15]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[205]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[253]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[1120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]

Drug(s) Affected By Histone chaperone ASF1B (ASF1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[1120]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[320]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[463]

Drug(s) Affected By Anoctamin-10 (ANO10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[356]
Bortezomib	DMNO38U	Leukemia		Approved	[269]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[190]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase FKBP14 (FKBP14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[186]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[171]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[22]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[306]

Drug(s) Affected By Telomeric repeat-binding factor 2-interacting protein 1 (TERF2IP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[184]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[1234]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[26]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[302]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[271]

Drug(s) Affected By CDGSH iron-sulfur domain-containing protein 1 (CISD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[250]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[270]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[357]

Drug(s) Affected By GEM-interacting protein (GMIP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[359]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[27]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[27]

Drug(s) Affected By Calcium-binding and coiled-coil domain-containing protein 1 (CALCOCO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[1053]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[527]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[930]
PEITC	DMOMN31	Prostate cancer	2C82.0	Phase 2	[1229]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[1059]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[1235]

Drug(s) Affected By GMP reductase 2 (GMPR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[190]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[358]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[184]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[176]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[715]

Drug(s) Affected By Vesicular glutamate transporter 2 (SLC17A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[556]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[334]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[622]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[171]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]

Drug(s) Affected By Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 (B3GAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[263]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[263]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[1236]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[177]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[225]

Drug(s) Affected By Hepatocyte nuclear factor 6 (ONECUT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1029]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[315]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[886]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[772]

Drug(s) Affected By Origin recognition complex subunit 3 (ORC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[529]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[927]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]

Drug(s) Affected By DnaJ homolog subfamily B member 9 (DNAJB9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[460]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[32]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[783]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[460]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[309]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[309]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[1120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[225]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[309]

Drug(s) Affected By Dickkopf-related protein 4 (DKK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1237]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[184]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[959]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[304]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]

Drug(s) Affected By Alpha-catulin (CTNNAL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[177]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[145]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[154]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[1170]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]

Drug(s) Affected By Dickkopf-related protein 2 (DKK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[225]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[68]
Indomethacin	DMSC4A7	Bursitis		Approved	[621]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[358]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[690]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[386]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[302]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]

Drug(s) Affected By Protein DBF4 homolog A (DBF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[84]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[99]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[145]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[557]

Drug(s) Affected By Death domain-associated protein 6 (DAXX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[177]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[27]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1238]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[1239]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[363]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Bendamustine hydrochloride	DMFH15Z	leukaemia	2A60-2B33	Approved	[1240]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[63]

Drug(s) Affected By Lysine-specific demethylase 5B (KDM5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[30]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[318]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[188]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[190]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]

Drug(s) Affected By Poly polymerase 2 (PARP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[1241]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[247]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[190]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[516]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[768]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[368]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[768]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[190]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]

Drug(s) Affected By Transcription factor COE1 (EBF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[1242]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[1243]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[557]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[57]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[193]

Drug(s) Affected By Probable ribosome biogenesis protein RLP24 (RSL24D1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[940]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[1119]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[772]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[731]

Drug(s) Affected By Inactive cell surface hyaluronidase CEMIP2 (CEMIP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[311]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[340]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[340]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[340]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]

Drug(s) Affected By Ena/VASP-like protein (EVL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[563]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[445]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[185]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[26]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[176]

Drug(s) Affected By E3 ISG15--protein ligase HERC5 (HERC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[308]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[206]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[308]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[308]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[308]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[263]

Drug(s) Affected By Meteorin (METRN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[1242]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[918]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[57]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]

Drug(s) Affected By Lymphoid enhancer-binding factor 1 (LEF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[1244]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[841]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[149]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[1245]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[928]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[1180]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[1246]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[171]

Drug(s) Affected By ADP-sugar pyrophosphatase (NUDT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[718]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[323]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[271]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[272]

Drug(s) Affected By Angiopoietin-related protein 2 (ANGPTL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[363]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[207]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[527]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[386]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[622]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[314]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]

Drug(s) Affected By Proteasome activator complex subunit 2 (PSME2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[469]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[315]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[81]
MG-132	DMKA2YS	N. A.	N. A.	Preclinical	[1247]

Drug(s) Affected By Cadherin-9 (CDH9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[57]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[57]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[171]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[177]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[57]

Drug(s) Affected By Cadherin-7 (CDH7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[886]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[225]

Drug(s) Affected By Frizzled-4 (FZD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[381]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[1170]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[368]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[421]

Drug(s) Affected By Targeting protein for Xklp2 (TPX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[320]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[301]

Drug(s) Affected By Frizzled-10 (FZD10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[556]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[207]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[356]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[1170]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[57]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[1119]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[177]

Drug(s) Affected By A-kinase anchor protein 8-like (AKAP8L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[249]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[171]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[180]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[195]

Drug(s) Affected By Neurogenic locus notch homolog protein 3 (NOTCH3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1248]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[687]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[301]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[1249]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[376]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]

Drug(s) Affected By Ras GTPase-activating protein-binding protein 2 (G3BP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[186]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[27]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[27]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase E (PPIE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[385]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[385]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[271]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
PP-242	DM2348V	Discovery agent	N.A.	Investigative	[492]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[180]

Drug(s) Affected By Forkhead box protein J3 (FOXJ3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[844]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[110]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[323]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]

Drug(s) Affected By Microtubule-associated protein RP/EB family member 3 (MAPRE3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[132]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[311]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[479]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[1250]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]

Drug(s) Affected By Structural maintenance of chromosomes protein 3 (SMC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[159]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Bortezomib	DMNO38U	Leukemia		Approved	[269]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[223]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[322]

Drug(s) Affected By DNA replication complex GINS protein PSF2 (GINS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[317]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[254]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[162]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[184]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[320]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]

Drug(s) Affected By Ribitol-5-phosphate xylosyltransferase 1 (RXYLT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[27]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[270]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[225]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-5 (ATF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[477]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[105]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[984]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[1251]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[301]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[945]

Drug(s) Affected By Phospholipid-transporting ATPase IF (ATP11B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[445]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[171]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[186]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[148]

Drug(s) Affected By Nischarin (NISCH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[351]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[207]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[351]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[1118]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[27]

Drug(s) Affected By AP-3 complex subunit mu-1 (AP3M1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[207]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[250]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[57]

Drug(s) Affected By Nucleolar protein 58 (NOP58)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[184]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[250]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[110]

Drug(s) Affected By N-acetylglucosamine-6-phosphate deacetylase (AMDHD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[179]

Drug(s) Affected By U6 snRNA-associated Sm-like protein LSm2 (LSM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[930]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
PP-242	DM2348V	Discovery agent	N.A.	Investigative	[492]

Drug(s) Affected By Endophilin-B1 (SH3GLB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[74]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[32]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[421]

Drug(s) Affected By Dehydrogenase/reductase SDR family member 7 (DHRS7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1148]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[959]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]

Drug(s) Affected By PRELI domain containing protein 3B (PRELID3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[171]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[323]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[185]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[185]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[27]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[1119]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase-like 1 (PPIL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[177]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[110]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[361]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[1151]

Drug(s) Affected By Large ribosomal subunit protein eL36 (RPL36)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[358]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[930]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1252]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[662]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[491]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]

Drug(s) Affected By Metal-response element-binding transcription factor 2 (MTF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[959]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[175]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[941]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[353]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[26]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[271]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]

Drug(s) Affected By Disheveled-associated activator of morphogenesis 1 (DAAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[26]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[268]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[195]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[183]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[270]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[66]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[81]

Drug(s) Affected By Hypoxia up-regulated protein 1 (HYOU1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[1120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[190]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[358]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[305]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[470]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[1253]

Drug(s) Affected By Protocadherin alpha-9 (PCDHA9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[225]
Octanal	DMTN0OK	N. A.	N. A.	Investigative	[1254]

Drug(s) Affected By Protocadherin alpha-1 (PCDHA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[177]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[1116]

Drug(s) Affected By DnaJ homolog subfamily C member 15 (DNAJC15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[421]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[617]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[1255]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[421]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[22]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[218]

Drug(s) Affected By Phosphoserine aminotransferase (PSAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[460]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[53]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[104]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[460]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[309]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[309]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[191]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[23]

Drug(s) Affected By Chloride intracellular channel protein 4 (CLIC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[395]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[460]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[342]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[189]

Drug(s) Affected By Transforming acidic coiled-coil-containing protein 3 (TACC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[30]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[219]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[219]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[539]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[539]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[33]

Drug(s) Affected By Proton-coupled zinc antiporter SLC30A1 (SLC30A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[317]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[253]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1107]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[516]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[181]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[351]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[148]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[114]

Drug(s) Affected By Cadherin-10 (CDH10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[57]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[21]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[251]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[358]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[314]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[22]

Drug(s) Affected By Nuclear receptor coactivator 3 (NCOA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[588]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[1256]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[515]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[22]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[225]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[182]
Bortezomib	DMNO38U	Leukemia		Approved	[269]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Aurora kinase B (AURKB)	TT5LS6T	AURKB_HUMAN	Inhibitor	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
(3R)-3-hydroxyacyl-CoA dehydrogenase (HSD17B8)	OTX1DWEF	DHB8_HUMAN	Gene/Protein Processing	[3]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (PLCB3)	OT0OMDEM	PLCB3_HUMAN	Gene/Protein Processing	[3]
10 kDa heat shock protein, mitochondrial (HSPE1)	OT7JSZLB	CH10_HUMAN	Gene/Protein Processing	[3]
14-3-3 protein beta/alpha	OTGBS3RF	1433B_HUMAN	Gene/Protein Processing	[3]
2-aminoethanethiol dioxygenase (ADO)	OTRLGQ7V	AEDO_HUMAN	Gene/Protein Processing	[3]
2-aminomuconic semialdehyde dehydrogenase (ALDH8A1)	OTINY3MW	AL8A1_HUMAN	Gene/Protein Processing	[3]
5'-3' exoribonuclease 2	OT7PNO08	XRN2_HUMAN	Gene/Protein Processing	[3]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 (PFKFB4)	OTQYEXL2	F264_HUMAN	Gene/Protein Processing	[3]
60 kDa heat shock protein, mitochondrial (HSPD1)	OTTO1Y11	CH60_HUMAN	Gene/Protein Processing	[3]
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[4]

References

• [1] Deguelin, an Aurora B Kinase Inhibitor, Exhibits Potent Anti-Tumor Effect in Human Esophageal Squamous Cell Carcinoma. EBioMedicine. 2017 Dec;26:100-111.
• [2] An Electrophilic Deguelin Analogue Inhibits STAT3 Signaling in H- Ras-Transformed Human Mammary Epithelial Cells: The Cysteine 259 Residue as a Potential Target. Biomedicines. 2020 Oct 12;8(10):407.
• [3] Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors. Arch Toxicol. 2021 Feb;95(2):591-615. doi: 10.1007/s00204-020-02970-5. Epub 2021 Jan 29.
• [4] Deguelin inhibits the migration and invasion of lung cancer A549 and H460 cells via regulating actin cytoskeleton rearrangement. Int J Clin Exp Pathol. 2015 Dec 1;8(12):15582-90. eCollection 2015.
• [5] A phase I trial of AT9283 (a selective inhibitor of aurora kinases) in children and adolescents with solid tumors: a Cancer Research UK study. Clin Cancer Res. 2015 Jan 15;21(2):267-73.
• [6] Cell cycle kinases as therapeutic targets for cancer. Nat Rev Drug Discov. 2009 Jul;8(7):547-66.
• [7] A comparison of physicochemical property profiles of marketed oral drugs and orally bioavailable anti-cancer protein kinase inhibitors in clinical development. Curr Top Med Chem. 2007;7(14):1408-22.
• [8] Preclinical characterization of ABT-348, a kinase inhibitor targeting the aurora, vascular endothelial growth factor receptor/platelet-derived growth factor receptor, and Src kinase families. J Pharmacol Exp Ther. 2012 Dec;343(3):617-27.
• [9] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1936).
• [10] Clinical pipeline report, company report or official report of Cyclacel.
• [11] Preclinical evaluation of AMG 900, a novel potent and highly selective pan-aurora kinase inhibitor with activity in taxane-resistant tumor cell lines. Cancer Res. 2010 Dec 1;70(23):9846-54.
• [12] SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivo. Cancer Chemother Pharmacol. 2010 Mar;65(4):707-17.
• [13] doi: 10.1158/1535-7163.TARG-13-B281
• [14] Preclinical characterization of Aurora kinase inhibitor R763/AS703569 identified through an image-based phenotypic screen. J Cancer Res Clin Oncol. 2010 Jan;136(1):99-113.
• [15] Time series analysis of oxidative stress response patterns in HepG2: a toxicogenomics approach. Toxicology. 2013 Apr 5;306:24-34.
• [16] Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
• [17] Species-specific toxicity of diclofenac and troglitazone in primary human and rat hepatocytes. Chem Biol Interact. 2009 Apr 15;179(1):17-24.
• [18] C/EBPalpha inactivation in FAK-overexpressed HL-60 cells impairs cell differentiation. Cell Signal. 2006 Jul;18(7):955-63. doi: 10.1016/j.cellsig.2005.08.014. Epub 2005 Oct 14.
• [19] Arsenic trioxide promotes senescence and regulates the balance of adipogenic and osteogenic differentiation in human mesenchymal stem cells. Acta Biochim Biophys Sin (Shanghai). 2011 Mar;43(3):204-9. doi: 10.1093/abbs/gmq130. Epub 2011 Jan 21.
• [20] Effects of nevirapine and efavirenz on human adipocyte differentiation, gene expression, and release of adipokines and cytokines. Antiviral Res. 2011 Aug;91(2):112-9. doi: 10.1016/j.antiviral.2011.04.018. Epub 2011 May 17.
• [21] THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
• [22] Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
• [23] Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes. Toxicol Lett. 2018 Jun 1;289:1-13.
• [24] Cannabidiol and Oxygen-Ozone Combination Induce Cytotoxicity in Human Pancreatic Ductal Adenocarcinoma Cell Lines. Cancers (Basel). 2020 Sep 27;12(10):2774. doi: 10.3390/cancers12102774.
• [25] trans-Resveratrol inhibits H2O2-induced adenocarcinoma gastric cells proliferation via inactivation of MEK1/2-ERK1/2-c-Jun signalling axis. Biochem Pharmacol. 2009 Feb 1;77(3):337-47. doi: 10.1016/j.bcp.2008.10.034. Epub 2008 Nov 6.
• [26] Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
• [27] Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
• [28] Regulation of genistein-induced differentiation in human acute myeloid leukaemia cells (HL60, NB4) Protein kinase modulation and reactive oxygen species generation. Biochem Pharmacol. 2009 Feb 1;77(3):384-96. doi: 10.1016/j.bcp.2008.10.035. Epub 2008 Nov 6.
• [29] Apoptosis induced by arsenic trioxide in leukemia U937 cells is dependent on activation of p38, inactivation of ERK and the Ca2+-dependent production of superoxide. Int J Cancer. 2001 May 15;92(4):518-26. doi: 10.1002/ijc.1220.
• [30] Expression profile analysis of human peripheral blood mononuclear cells in response to aspirin. Arch Immunol Ther Exp (Warsz). 2005 Mar-Apr;53(2):151-8.
• [31] Cannabis-induced cytotoxicity in leukemic cell lines: the role of the cannabinoid receptors and the MAPK pathway. Blood. 2005 Feb 1;105(3):1214-21. doi: 10.1182/blood-2004-03-1182. Epub 2004 Sep 28.
• [32] Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury. Arch Toxicol. 2020 Apr;94(4):1151-1172. doi: 10.1007/s00204-020-02691-9. Epub 2020 Mar 10.
• [33] Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
• [34] Different apoptosis ratios and gene expressions in two human cell lines after sevoflurane anaesthesia. Acta Anaesthesiol Scand. 2009 Oct;53(9):1192-9. doi: 10.1111/j.1399-6576.2009.02036.x. Epub 2009 Jun 30.
• [35] [Mechanisms underlying the effect of arsenic trioxide on proliferation inhibition and apoptosis induction in myeloma cell line u266]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2007 Oct;15(5):982-5.
• [36] Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPAR-dependent pathway. Oncotarget. 2016 Mar 1;7(9):10345-62. doi: 10.18632/oncotarget.7213.
• [37] Induction of apoptosis by cidofovir in human papillomavirus (HPV)-positive cells. Oncol Res. 2000;12(9-10):397-408. doi: 10.3727/096504001108747855.
• [38] Comparison of burst of reactive oxygen species and activation of caspase-3 in apoptosis of K562 and HL-60 cells induced by docetaxel. Cancer Lett. 2004 Oct 8;214(1):103-13. doi: 10.1016/j.canlet.2004.03.047.
• [39] Induction of mitochondrial manganese superoxide dismutase confers resistance to apoptosis in acute myeloblastic leukaemia cells exposed to etoposide. Br J Haematol. 2000 Mar;108(3):574-81. doi: 10.1046/j.1365-2141.2000.01852.x.
• [40] Cisplatin-enhanced sensitivity of glioblastoma multiforme U251 cells to adenovirus-delivered TRAIL in vitro. Tumour Biol. 2010 Dec;31(6):613-22. doi: 10.1007/s13277-010-0077-x. Epub 2010 Jul 11.
• [41] Insulin-like growth factor I is the key growth factor in serum that protects neuroblastoma cells from hyperosmotic-induced apoptosis. J Cell Physiol. 2000 Jan;182(1):24-32. doi: 10.1002/(SICI)1097-4652(200001)182:1<24::AID-JCP3>3.0.CO;2-6.
• [42] mRNA expression analysis of a variety of apoptosis-related genes, including the novel gene of the BCL2-family, BCL2L12, in HL-60 leukemia cells after treatment with carboplatin and doxorubicin. Biol Chem. 2004 Nov;385(11):1099-103. doi: 10.1515/BC.2004.143.
• [43] Neurokinin-1 receptor (NK1R) inhibition sensitizes APL cells to anti-tumor effect of arsenic trioxide via restriction of NF-B axis: Shedding new light on resistance to Aprepitant. Int J Biochem Cell Biol. 2018 Oct;103:105-114. doi: 10.1016/j.biocel.2018.08.010. Epub 2018 Aug 23.
• [44] Cannabidiol Modulates the Expression of Alzheimer's Disease-Related Genes in Mesenchymal Stem Cells. Int J Mol Sci. 2016 Dec 23;18(1):26. doi: 10.3390/ijms18010026.
• [45] Effects and mechanisms of betulinic acid on improving EGFR TKI-resistance of lung cancer cells. Environ Toxicol. 2018 Nov;33(11):1153-1159.
• [46] The protective effects of liraglutide on AD-like neurodegeneration induced by oxidative stress in human neuroblastoma SH-SY5Y cells. Chem Biol Interact. 2019 Sep 1;310:108688. doi: 10.1016/j.cbi.2019.06.001. Epub 2019 Jun 4.
• [47] Dysregulation of integrin-linked kinase (ILK) signaling in colonic polyposis. Oncogene. 2001 Sep 27;20(43):6250-7. doi: 10.1038/sj.onc.1204791.
• [48] Differential effects of simvastatin and pravastatin on expression of Alzheimer's disease-related genes in human astrocytes and neuronal cells. J Lipid Res. 2009 Oct;50(10):2095-102. doi: 10.1194/jlr.M900236-JLR200. Epub 2009 May 21.
• [49] Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells. Biol Pharm Bull. 2013;36(6):944-51. doi: 10.1248/bpb.b12-01004.
• [50] Suppression of NF-kappaB and GSK-3beta is involved in colon cancer cell growth inhibition by the PPAR agonist troglitazone. Chem Biol Interact. 2010 Oct 6;188(1):75-85. doi: 10.1016/j.cbi.2010.06.001. Epub 2010 Jun 9.
• [51] Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
• [52] NGBR is required to ameliorate type 2 diabetes in mice by enhancing insulin sensitivity. J Biol Chem. 2021 Jan-Jun;296:100624. doi: 10.1016/j.jbc.2021.100624. Epub 2021 Apr 2.
• [53] MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia. Cell Biol Toxicol. 2023 Feb;39(1):201-216. doi: 10.1007/s10565-021-09639-4. Epub 2021 Sep 28.
• [54] The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
• [55] Flavonoids-induced accumulation of hypoxia-inducible factor (HIF)-1alpha/2alpha is mediated through chelation of iron. J Cell Biochem. 2008 Apr 15;103(6):1989-98. doi: 10.1002/jcb.21588.
• [56] Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7653-8.
• [57] A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
• [58] Ibuprofen-mediated reduction of hypoxia-inducible factors HIF-1alpha and HIF-2alpha in prostate cancer cells. Clin Cancer Res. 2003 Aug 1;9(8):3150-7.
• [59] Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
• [60] Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
• [61] Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
• [62] Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
• [63] Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
• [64] Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
• [65] Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
• [66] Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
• [67] High-throughput ectopic expression screen for tamoxifen resistance identifies an atypical kinase that blocks autophagy. Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2058-63.
• [68] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
• [69] Cannabidiol promotes apoptosis via regulation of XIAP/Smac in gastric cancer. Cell Death Dis. 2019 Nov 7;10(11):846. doi: 10.1038/s41419-019-2001-7.
• [70] Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
• [71] Asbestos-induced alveolar epithelial cell apoptosis. The role of endoplasmic reticulum stress response. Am J Respir Cell Mol Biol. 2013 Dec;49(6):892-901. doi: 10.1165/rcmb.2013-0053OC.
• [72] Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity. Cell Biol Toxicol. 2021 Apr;37(2):151-175. doi: 10.1007/s10565-020-09537-1. Epub 2020 Jun 14.
• [73] Quercetin enhances apoptotic effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in ovarian cancer cells through reactive oxygen species (ROS) mediated CCAAT enhancer-binding protein homologous protein (CHOP)-death receptor 5 pathway. Cancer Sci. 2014 May;105(5):520-7. doi: 10.1111/cas.12395. Epub 2014 Apr 11.
• [74] Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
• [75] Pyrazinamide-induced hepatotoxicity is alleviated by 4-PBA via inhibition of the PERK-eIF2-ATF4-CHOP pathway. Toxicology. 2017 Mar 1;378:65-75. doi: 10.1016/j.tox.2017.01.002. Epub 2017 Jan 4.
• [76] ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
• [77] Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1. FASEB J. 2012 Apr;26(4):1535-48. doi: 10.1096/fj.11-198184. Epub 2011 Dec 23.
• [78] Discovery of molecular mechanisms of neuroprotection using cell-based bioassays and oligonucleotide arrays. Physiol Genomics. 2002 Oct 29;11(2):45-52. doi: 10.1152/physiolgenomics.00064.2002.
• [79] Inhibition of invasion and induction of apoptosis by selenium in human malignant brain tumour cells in vitro. Int J Oncol. 2007 May;30(5):1263-71.
• [80] Dietary supplementation with the anti-tumour promoter quercetin: its effects on matrix metalloproteinase gene regulation. Mutat Res. 2001 Sep 1;480-481:269-76. doi: 10.1016/s0027-5107(01)00184-1.
• [81] Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
• [82] Arsenic trioxide (As2O3) inhibits invasion of HT1080 human fibrosarcoma cells: role of nuclear factor-kappaB and reactive oxygen species. J Cell Biochem. 2005 Aug 1;95(5):955-69. doi: 10.1002/jcb.20452.
• [83] Aspirin inhibits MMP-2 and MMP-9 expressions and activities through upregulation of PPARalpha/gamma and TIMP gene expressions in ox-LDL-stimulated macrophages derived from human monocytes. Pharmacology. 2009;83(1):18-25. doi: 10.1159/000166183. Epub 2008 Oct 30.
• [84] Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
• [85] Oxidative Stress-Protective and Anti-Melanogenic Effects of Loliolide and Ethanol Extract from Fresh Water Green Algae, Prasiola japonica. Int J Mol Sci. 2018 Sep 18;19(9):2825. doi: 10.3390/ijms19092825.
• [86] The effects of a novel synthetic retinoid, seletinoid G, on the expression of extracellular matrix proteins in aged human skin in vivo. Clin Chim Acta. 2005 Dec;362(1-2):161-9. doi: 10.1016/j.cccn.2005.06.016. Epub 2005 Aug 1.
• [87] Ciprofloxacin enhances the stimulation of matrix metalloproteinase 3 expression by interleukin-1beta in human tendon-derived cells. A potential mechanism of fluoroquinolone-induced tendinopathy. Arthritis Rheum. 2002 Nov;46(11):3034-40. doi: 10.1002/art.10617.
• [88] Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
• [89] Simvastatin reduces MMP1 expression in human smooth muscle cells cultured on polymerized collagen by inhibiting Rac1 activation. Arterioscler Thromb Vasc Biol. 2007 May;27(5):1043-9. doi: 10.1161/ATVBAHA.107.139881. Epub 2007 Feb 15.
• [90] Quercetin inhibits matrix metalloproteinase-1 expression in human vascular endothelial cells through extracellular signal-regulated kinase. Arch Biochem Biophys. 2001 Jul 1;391(1):72-8. doi: 10.1006/abbi.2001.2402.
• [91] Rofecoxib regulates the expression of genes related to the matrix metalloproteinase pathway in humans: implication for the adverse effects of cyclooxygenase-2 inhibitors. Clin Pharmacol Ther. 2006 Apr;79(4):303-15. doi: 10.1016/j.clpt.2005.12.306.
• [92] Interaction between the aryl hydrocarbon receptor and retinoic acid pathways increases matrix metalloproteinase-1 expression in keratinocytes. J Biol Chem. 2004 Jun 11;279(24):25284-93. doi: 10.1074/jbc.M402168200. Epub 2004 Apr 9.
• [93] Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
• [94] High-dose mitoxantrone induces programmed cell death or apoptosis in human myeloid leukemia cells. Blood. 1993 Nov 15;82(10):3133-40.
• [95] Gene expression data from acetaminophen-induced toxicity in human hepatic in vitro systems and clinical liver samples. Data Brief. 2016 Mar 26;7:1052-1057. doi: 10.1016/j.dib.2016.03.069. eCollection 2016 Jun.
• [96] Inhibition of autophagic flux differently modulates cannabidiol-induced death in 2D and 3D glioblastoma cell cultures. Sci Rep. 2020 Feb 14;10(1):2687. doi: 10.1038/s41598-020-59468-4.
• [97] Nitrogen mustard prevents transport of Fra-1 into the nucleus to promote c-Fos- and FosB-dependent IL-8 induction in injured mouse epidermis. Toxicol Lett. 2020 Feb 1;319:256-263. doi: 10.1016/j.toxlet.2019.10.006. Epub 2019 Oct 19.
• [98] Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res. 2002 Aug 1;62(15):4419-26.
• [99] Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun. 2008 Dec 19;377(3):797-802.
• [100] Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cells. J Biol Chem. 2002 Nov 15;277(46):43648-58. doi: 10.1074/jbc.M203214200. Epub 2002 Sep 6.
• [101] [Regulation mechanism of autophagy-related protein LC3 by c-Jun in methotrexate resistant human choriocarcinoma JEG-3 cells]. Zhonghua Fu Chan Ke Za Zhi. 2014 Jul;49(7):531-5.
• [102] Nobiletin, a citrus flavonoid, down-regulates matrix metalloproteinase-7 (matrilysin) expression in HT-29 human colorectal cancer cells. Biosci Biotechnol Biochem. 2005 Feb;69(2):307-14. doi: 10.1271/bbb.69.307.
• [103] Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4050-61.
• [104] Global effects of inorganic arsenic on gene expression profile in human macrophages. Mol Immunol. 2009 Feb;46(4):649-56.
• [105] Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
• [106] The differential cancer growth associated with anaesthetics in a cancer xenograft model of mice: mechanisms and implications of postoperative cancer recurrence. Cell Biol Toxicol. 2023 Aug;39(4):1561-1575. doi: 10.1007/s10565-022-09747-9. Epub 2022 Aug 12.
• [107] Effect of mood stabilizers on gene expression in lymphoblastoid cells. J Neural Transm (Vienna). 2010 Feb;117(2):155-64.
• [108] Histamine H4 receptor agonists have more activities than H4 agonism in antigen-specific human T-cell responses. Immunology. 2007 Jun;121(2):266-75. doi: 10.1111/j.1365-2567.2007.02574.x. Epub 2007 Mar 7.
• [109] AMPK-dependent signaling modulates the suppression of invasion and migration by fenofibrate in CAL 27 oral cancer cells through NF-B pathway. Environ Toxicol. 2016 Jul;31(7):866-76. doi: 10.1002/tox.22097. Epub 2014 Dec 24.
• [110] Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
• [111] Gaseous nitrogen oxide promotes human lung cancer cell line A549 migration, invasion, and metastasis via iNOS-mediated MMP-2 production. Toxicol Sci. 2008 Dec;106(2):364-75. doi: 10.1093/toxsci/kfn195. Epub 2008 Sep 16.
• [112] Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur J Nutr. 2005 Mar;44(3):143-56. doi: 10.1007/s00394-004-0503-1. Epub 2004 Apr 30.
• [113] Retinoic acid remodels extracellular matrix (ECM) of cultured human fetal palate mesenchymal cells (hFPMCs) through down-regulation of TGF-/Smad signaling. Toxicol Lett. 2014 Mar 3;225(2):208-15. doi: 10.1016/j.toxlet.2013.12.013. Epub 2013 Dec 24.
• [114] Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
• [115] Tetracaine downregulates matrix metalloproteinase activity and inhibits invasiveness of strongly metastatic MDA-MB-231 human breast cancer cells. Chem Biol Interact. 2023 Nov 1;385:110730. doi: 10.1016/j.cbi.2023.110730. Epub 2023 Oct 7.
• [116] Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
• [117] Downregulation of mitogen-activated protein kinases (MAPKs) in chronic ethanol-induced fatty liver. Toxicol Mech Methods. 2020 Jul;30(6):407-416. doi: 10.1080/15376516.2020.1747126. Epub 2020 Apr 1.
• [118] Progesterone increases csk homologous kinase in HMC-1560 human mast cells and reduces cell proliferation. J Cell Biochem. 2007 Dec 1;102(5):1271-80. doi: 10.1002/jcb.21357.
• [119] A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16657-62. doi: 10.1073/pnas.0707936104. Epub 2007 Oct 9.
• [120] The stent-eluting drugs sirolimus and paclitaxel suppress healing of the endothelium by induction of autophagy. Am J Pathol. 2009 Nov;175(5):2226-34.
• [121] Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids. J Biol Chem. 2005 Sep 9;280(36):31498-507. doi: 10.1074/jbc.M505537200. Epub 2005 Jul 13.
• [122] Treatment with anticancer agents induces dysregulation of specific Wnt signaling pathways in human ovarian luteinized granulosa cells in vitro. Toxicol Sci. 2013 Nov;136(1):183-92. doi: 10.1093/toxsci/kft175. Epub 2013 Aug 16.
• [123] Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
• [124] Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
• [125] Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2. Int J Cancer. 2006 Mar 15;118(6):1370-80. doi: 10.1002/ijc.21537.
• [126] Development of an alternative zebrafish model for drug-induced intestinal toxicity. J Appl Toxicol. 2018 Feb;38(2):259-273. doi: 10.1002/jat.3520. Epub 2017 Oct 13.
• [127] The effects of quercetin in cultured human RPE cells under oxidative stress and in Ccl2/Cx3cr1 double deficient mice. Exp Eye Res. 2010 Jul;91(1):15-25.
• [128] Mechanism of simvastatin-induced K562 cell apoptosis. Pharmacology. 2009;84(4):191-5. doi: 10.1159/000235907. Epub 2009 Sep 2.
• [129] The anti-inflammatory flavones quercetin and kaempferol cause inhibition of inducible nitric oxide synthase, cyclooxygenase-2 and reactive C-protein, and down-regulation of the nuclear factor kappaB pathway in Chang Liver cells. Eur J Pharmacol. 2007 Feb 28;557(2-3):221-9.
• [130] Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model. Toxicol In Vitro. 2009 Oct;23(7):1387-95.
• [131] D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis. Apoptosis. 2012 Oct;17(10):1079-94.
• [132] Integrated analysis of rifampicin-induced microRNA and gene expression changes in human hepatocytes. Drug Metab Pharmacokinet. 2014;29(4):333-40.
• [133] Docosahexaenoic acid regulates gene expression in HUVEC cells treated with polycyclic aromatic hydrocarbons. Toxicol Lett. 2015 Jul 16;236(2):75-81.
• [134] Etoposide induces necrosis through p53-mediated antiapoptosis in human kidney proximal tubule cells. Toxicol Sci. 2015 Nov;148(1):204-19.
• [135] Conjugated linoleic acid, unlike other unsaturated fatty acids, strongly induces glutathione synthesis without any lipoperoxidation. Br J Nutr. 2006 Nov;96(5):811-9.
• [136] COX-2 and PPAR-gama confer cannabidiol-induced apoptosis of human lung cancer cells. Mol Cancer Ther. 2013 Jan;12(1):69-82.
• [137] Mitochondrial involvement in schizophrenia and other functional psychoses. Neurochem Res. 1996 Sep;21(9):995-1004.
• [138] Immunomodulatory effect of selective serotonin reuptake inhibitors (SSRIs) on human T lymphocyte function and gene expression. Eur Neuropsychopharmacol. 2007 Dec;17(12):774-80.
• [139] Stimulation of cyclooxygenase-2 expression by bone-derived transforming growth factor-beta enhances bone metastases in breast cancer. Cancer Res. 2006 Feb 15;66(4):2067-73.
• [140] Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
• [141] An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
• [142] A2E selectively induces cox-2 in ARPE-19 and human neural cells. Curr Eye Res. 2006 Mar;31(3):259-63.
• [143] Contrasting effects of fluoroquinolone antibiotics on the expression of the collagenases, matrix metalloproteinases (MMP)-1 and -13, in human tendon-derived cells. Rheumatology (Oxford). 2005 Dec;44(12):1514-7. doi: 10.1093/rheumatology/kei087. Epub 2005 Sep 7.
• [144] Chloramphenicol causes mitochondrial stress, decreases ATP biosynthesis, induces matrix metalloproteinase-13 expression, and solid-tumor cell invasion. Toxicol Sci. 2010 Jul;116(1):140-50. doi: 10.1093/toxsci/kfq085. Epub 2010 Mar 25.
• [145] Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer Sci. 2007 Jun;98(6):890-9.
• [146] Matrix metalloproteinases of epithelial origin in facial sebum of patients with acne and their regulation by isotretinoin. J Invest Dermatol. 2005 Oct;125(4):673-84. doi: 10.1111/j.0022-202X.2005.23848.x.
• [147] Glucosamine promotes chondrogenic phenotype in both chondrocytes and mesenchymal stem cells and inhibits MMP-13 expression and matrix degradation. Osteoarthritis Cartilage. 2007 Jun;15(6):646-55. doi: 10.1016/j.joca.2007.01.014. Epub 2007 Mar 6.
• [148] Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. Arch Toxicol. 2016 Jan;90(1):159-80.
• [149] Ouabain impairs cell migration, and invasion and alters gene expression of human osteosarcoma U-2 OS cells. Environ Toxicol. 2017 Nov;32(11):2400-2413. doi: 10.1002/tox.22453. Epub 2017 Aug 10.
• [150] Expression profiling in squamous carcinoma cells reveals pleiotropic effects of vitamin D3 analog EB1089 signaling on cell proliferation, differentiation, and immune system regulation. Mol Endocrinol. 2002 Jun;16(6):1243-56.
• [151] Cytoskeletal activation and altered gene expression in endothelial barrier regulation by simvastatin. Am J Respir Cell Mol Biol. 2004 May;30(5):662-70. doi: 10.1165/rcmb.2003-0267OC. Epub 2003 Nov 20.
• [152] Quercetin inhibits migration and invasion of SAS human oral cancer cells through inhibition of NF-B and matrix metalloproteinase-2/-9 signaling pathways. Anticancer Res. 2013 May;33(5):1941-50.
• [153] Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
• [154] Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Toxicol Appl Pharmacol. 2012 Jun 1;261(2):204-16.
• [155] Combining prenylation inhibitors causes synergistic cytotoxicity, apoptosis and disruption of RAS-to-MAP kinase signalling in multiple myeloma cells. Br J Haematol. 2005 Sep;130(6):912-25. doi: 10.1111/j.1365-2141.2005.05696.x.
• [156] Pamidronate induced anti-proliferative, apoptotic, and anti-migratory effects in hepatocellular carcinoma. J Hepatol. 2006 Jan;44(1):142-50. doi: 10.1016/j.jhep.2005.09.022. Epub 2005 Nov 9.
• [157] RhoA GTPase inactivation by statins induces osteosarcoma cell apoptosis by inhibiting p42/p44-MAPKs-Bcl-2 signaling independently of BMP-2 and cell differentiation. Cell Death Differ. 2006 Nov;13(11):1845-56. doi: 10.1038/sj.cdd.4401873. Epub 2006 Feb 10.
• [158] Response rate of fibrosarcoma cells to cytotoxic drugs on the expression level correlates to the therapeutic response rate of fibrosarcomas and is mediated by regulation of apoptotic pathways. BMC Cancer. 2005 Jul 7;5:74. doi: 10.1186/1471-2407-5-74.
• [159] Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
• [160] Nicotinic modulation of gene expression in SH-SY5Y neuroblastoma cells. Brain Res. 2006 Oct 20;1116(1):39-49.
• [161] Protein expression profiling identifies molecular targets of quercetin as a major dietary flavonoid in human colon cancer cells. Proteomics. 2004 Jul;4(7):2160-74.
• [162] Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
• [163] Grouping of histone deacetylase inhibitors and other toxicants disturbing neural crest migration by transcriptional profiling. Neurotoxicology. 2015 Sep;50:56-70.
• [164] The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
• [165] Ouabain-induced apoptosis and Rho kinase: a novel caspase-2 cleavage site and fragment of Rock-2. Apoptosis. 2010 Dec;15(12):1494-506. doi: 10.1007/s10495-010-0529-1.
• [166] Niclosamide acts as a new inhibitor of vasculogenic mimicry in oral cancer through upregulation of miR-124 and downregulation of STAT3. Oncol Rep. 2018 Feb;39(2):827-833. doi: 10.3892/or.2017.6146. Epub 2017 Dec 11.
• [167] Transcriptomic Analysis of Stem Cells Treated with Moringin or Cannabidiol: Analogies and Differences in Inflammation Pathways. Int J Mol Sci. 2019 Nov 30;20(23):6039. doi: 10.3390/ijms20236039.
• [168] 5-Aza-2'-deoxycytidine and depsipeptide synergistically induce expression of BIK (BCL2-interacting killer). Biochem Biophys Res Commun. 2006 Dec 15;351(2):455-61. doi: 10.1016/j.bbrc.2006.10.055. Epub 2006 Oct 18.
• [169] Prenatal arsenic exposure and the epigenome: altered microRNAs associated with innate and adaptive immune signaling in newborn cord blood. Environ Mol Mutagen. 2014 Apr;55(3):196-208. doi: 10.1002/em.21842. Epub 2013 Dec 10.
• [170] Estrogen Regulates MAPK-Related Genes through Genomic and Nongenomic Interactions between IGF-I Receptor Tyrosine Kinase and Estrogen Receptor-Alpha Signaling Pathways in Human Uterine Leiomyoma Cells. J Signal Transduct. 2012;2012:204236. doi: 10.1155/2012/204236. Epub 2012 Oct 9.
• [171] Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
• [172] Effect of quercetin on apoptosis of PANC-1 cells. J Korean Surg Soc. 2013 Dec;85(6):249-60. doi: 10.4174/jkss.2013.85.6.249. Epub 2013 Nov 26.
• [173] Rifampicin-induced injury in L02 cells is alleviated by 4-PBA via inhibition of the PERK-ATF4-CHOP pathway. Toxicol In Vitro. 2016 Oct;36:186-196. doi: 10.1016/j.tiv.2016.07.017. Epub 2016 Jul 26.
• [174] Retinoic acid-induced downmodulation of telomerase activity in human cancer cells. Exp Mol Pathol. 2005 Oct;79(2):108-17.
• [175] Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
• [176] Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells. J Biol Chem. 2012 Dec 14;287(51):43137-55.
• [177] DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
• [178] Transcriptome and DNA methylation changes modulated by sulforaphane induce cell cycle arrest, apoptosis, DNA damage, and suppression of proliferation in human liver cancer cells. Food Chem Toxicol. 2020 Feb;136:111047. doi: 10.1016/j.fct.2019.111047. Epub 2019 Dec 12.
• [179] Bisphenol A and bisphenol S induce distinct transcriptional profiles in differentiating human primary preadipocytes. PLoS One. 2016 Sep 29;11(9):e0163318.
• [180] Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.
• [181] Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
• [182] Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
• [183] Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
• [184] Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
• [185] Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
• [186] LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
• [187] Arsenic-induced sumoylation of Mus81 is involved in regulating genomic stability. Cell Cycle. 2017 Apr 18;16(8):802-811. doi: 10.1080/15384101.2017.1302628. Epub 2017 Mar 20.
• [188] Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029.
• [189] Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
• [190] Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
• [191] Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
• [192] Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain. Toxicol Lett. 2015 Apr 16;234(2):139-50.
• [193] Endoplasmic reticulum stress impairs insulin signaling through mitochondrial damage in SH-SY5Y cells. Neurosignals. 2012;20(4):265-80.
• [194] DNA microarray analysis of changes in gene expression induced by 1,25-dihydroxyvitamin D3 in human promyelocytic leukemia HL-60 cells. Biomed Res. 2006 Jun;27(3):99-109. doi: 10.2220/biomedres.27.99.
• [195] Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
• [196] Mechanisms of indomethacin-induced alterations in the choline phospholipid metabolism of breast cancer cells. Neoplasia. 2006 Sep;8(9):758-71.
• [197] Low doses of BPF-induced hypertrophy in cardiomyocytes derived from human embryonic stem cells via disrupting the mitochondrial fission upon the interaction between ER and calcineurin A-DRP1 signaling pathway. Cell Biol Toxicol. 2022 Jun;38(3):409-426. doi: 10.1007/s10565-021-09615-y. Epub 2021 May 22.
• [198] Tea polyphenols direct Bmal1-driven ameliorating of the redox imbalance and mitochondrial dysfunction in hepatocytes. Food Chem Toxicol. 2018 Dec;122:181-193.
• [199] Statin-triggered cell death in primary human lung mesenchymal cells involves p53-PUMA and release of Smac and Omi but not cytochrome c. Biochim Biophys Acta. 2010 Apr;1803(4):452-67. doi: 10.1016/j.bbamcr.2009.12.005. Epub 2010 Jan 4.
• [200] Lon protease: a novel mitochondrial matrix protein in the interconnection between drug-induced mitochondrial dysfunction and endoplasmic reticulum stress. Br J Pharmacol. 2017 Dec;174(23):4409-4429. doi: 10.1111/bph.14045. Epub 2017 Nov 7.
• [201] Protective effects of silibinin against ethanol- or acetaldehyde-caused damage in liver cell lines involve the repression of mitochondrial fission. Toxicol In Vitro. 2022 Apr;80:105330. doi: 10.1016/j.tiv.2022.105330. Epub 2022 Feb 11.
• [202] Doxorubicin-induced mitophagy and mitochondrial damage is associated with dysregulation of the PINK1/parkin pathway. Toxicol In Vitro. 2018 Sep;51:1-10. doi: 10.1016/j.tiv.2018.05.001. Epub 2018 May 3.
• [203] Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells. J Cell Biochem. 2006 Aug 1;98(5):1163-84.
• [204] Transcriptome-based functional classifiers for direct immunotoxicity. Arch Toxicol. 2014 Mar;88(3):673-89.
• [205] Classification of heavy-metal toxicity by human DNA microarray analysis. Environ Sci Technol. 2007 May 15;41(10):3769-74.
• [206] Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
• [207] Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
• [208] Arsenic downregulates tight junction claudin proteins through p38 and NF-B in intestinal epithelial cell line, HT-29. Toxicology. 2017 Mar 15;379:31-39. doi: 10.1016/j.tox.2017.01.011. Epub 2017 Jan 20.
• [209] Palmitoylethanolamide and Cannabidiol Prevent Inflammation-induced Hyperpermeability of the Human Gut In Vitro and In Vivo-A Randomized, Placebo-controlled, Double-blind Controlled Trial. Inflamm Bowel Dis. 2019 May 4;25(6):1006-1018. doi: 10.1093/ibd/izz017.
• [210] Anti-invasive activity of sanguinarine through modulation of tight junctions and matrix metalloproteinase activities in MDA-MB-231 human breast carcinoma cells. Chem Biol Interact. 2009 May 15;179(2-3):185-91. doi: 10.1016/j.cbi.2008.11.009. Epub 2008 Nov 21.
• [211] Effects of glyphosate and aminomethylphosphonic acid on an isogeneic model of the human blood-brain barrier. Toxicol Lett. 2019 Apr;304:39-49. doi: 10.1016/j.toxlet.2018.12.013. Epub 2018 Dec 31.
• [212] Progesterone regulation of implantation-related genes: new insights into the role of oestrogen. Cell Mol Life Sci. 2007 Apr;64(7-8):1009-32.
• [213] Loxoprofen enhances intestinal barrier function via generation of its active metabolite by carbonyl reductase 1 in differentiated Caco-2?cells. Chem Biol Interact. 2021 Oct 1;348:109634. doi: 10.1016/j.cbi.2021.109634. Epub 2021 Sep 8.
• [214] Transcriptional signature of human macrophages exposed to the environmental contaminant benzo(a)pyrene. Toxicol Sci. 2010 Apr;114(2):247-59.
• [215] Involvement of claudin-5 in H(2)S-induced acute lung injury. J Toxicol Sci. 2020;45(5):293-304. doi: 10.2131/jts.45.293.
• [216] Gingival Stromal Cells as an In Vitro Model: Cannabidiol Modulates Genes Linked With Amyotrophic Lateral Sclerosis. J Cell Biochem. 2017 Apr;118(4):819-828. doi: 10.1002/jcb.25757. Epub 2016 Nov 28.
• [217] Effects of tobacco compounds on gene expression in fetal lung fibroblasts. Environ Toxicol. 2008 Aug;23(4):423-34.
• [218] Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
• [219] Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
• [220] Anti-oncogenic and pro-differentiation effects of clorgyline, a monoamine oxidase A inhibitor, on high grade prostate cancer cells. BMC Med Genomics. 2009 Aug 20;2:55. doi: 10.1186/1755-8794-2-55.
• [221] Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
• [222] Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells. Chem Res Toxicol. 2014 Mar 17;27(3):408-20.
• [223] Role of phenytoin in wound healing: microarray analysis of early transcriptional responses in human dermal fibroblasts. Biochem Biophys Res Commun. 2004 Feb 13;314(3):661-6. doi: 10.1016/j.bbrc.2003.12.146.
• [224] Epigenetic changes in individuals with arsenicosis. Chem Res Toxicol. 2011 Feb 18;24(2):165-7. doi: 10.1021/tx1004419. Epub 2011 Feb 4.
• [225] From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
• [226] Ribavirin inhibits colorectal cancer growth by downregulating PRMT5 expression and H3R8me2s and H4R3me2s accumulation. Toxicol Appl Pharmacol. 2021 Mar 15;415:115450. doi: 10.1016/j.taap.2021.115450. Epub 2021 Feb 9.
• [227] Effect of ellagic acid on the expression of human telomerase reverse transcriptase (hTERT) alpha+beta+ transcript in estrogen receptor-positive MCF-7 breast cancer cells. Clin Biochem. 2009 Sep;42(13-14):1358-62. doi: 10.1016/j.clinbiochem.2009.05.017. Epub 2009 Jun 6.
• [228] Antiproliferative effects of gefitinib are associated with suppression of E2F-1 expression and telomerase activity. Anticancer Res. 2006 Sep-Oct;26(5A):3387-91.
• [229] Inhibitory effects of selenium on telomerase activity and hTERT expression in cadmium-transformed 16HBE cells. Biomed Environ Sci. 2007 Aug;20(4):307-12.
• [230] Troglitazone suppresses telomerase activity independently of PPARgamma in estrogen-receptor negative breast cancer cells. BMC Cancer. 2010 Jul 22;10:390. doi: 10.1186/1471-2407-10-390.
• [231] Analysis of telomerase activity and RNA expression in a patient with acute promyelocytic leukemia treated with all-trans retinoic acid. Pediatr Blood Cancer. 2006 Apr;46(4):506-11. doi: 10.1002/pbc.20392.
• [232] Characterization of the functional and growth properties of long-term cell cultures established from a human somatostatinoma. Endocr Relat Cancer. 2006 Mar;13(1):79-93. doi: 10.1677/erc.1.00988.
• [233] Characterization of arsenic-induced cytogenetic alterations in acute promyelocytic leukemia cell line, NB4. Med Oncol. 2012 Jun;29(2):1209-16. doi: 10.1007/s12032-011-9946-4. Epub 2011 May 5.
• [234] Lunasin, a novel seed peptide, sensitizes human breast cancer MDA-MB-231 cells to aspirin-arrested cell cycle and induced apoptosis. Chem Biol Interact. 2010 Jul 30;186(2):127-34. doi: 10.1016/j.cbi.2010.04.027. Epub 2010 May 21.
• [235] Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
• [236] Melanoma coordinates general and cell-specific mechanisms to promote methotrexate resistance. Exp Cell Res. 2012 Jun 10;318(10):1146-59.
• [237] Involvement of the activation of Nrf2/HO-1, p38 MAPK signaling pathways and endoplasmic reticulum stress in furazolidone induced cytotoxicity and S phase arrest in human hepatocyte L02 cells: modulation of curcumin. Toxicol Mech Methods. 2017 Mar;27(3):165-172. doi: 10.1080/15376516.2016.1273424. Epub 2017 Jan 8.
• [238] Long-term exposure to zidovudine delays cell cycle progression, induces apoptosis, and decreases telomerase activity in human hepatocytes. Toxicol Sci. 2009 Sep;111(1):120-30. doi: 10.1093/toxsci/kfp136. Epub 2009 Jun 18.
• [239] ATR, PML, and CHK2 play a role in arsenic trioxide-induced apoptosis. J Biol Chem. 2006 Sep 29;281(39):28764-71. doi: 10.1074/jbc.M604392200. Epub 2006 Aug 3.
• [240] Identification of small molecule proliferating cell nuclear antigen (PCNA) inhibitor that disrupts interactions with PIP-box proteins and inhibits DNA replication. J Biol Chem. 2012 Apr 20;287(17):14289-300. doi: 10.1074/jbc.M112.353201. Epub 2012 Mar 1.
• [241] Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity. Toxicology. 2014 Jan 6;315:8-16. doi: 10.1016/j.tox.2013.10.009. Epub 2013 Nov 6.
• [242] Regulation of DR-5 protein and mitochondrial transmembrane potential by gemcitabine, a possible mechanism of gemcitabine-enhanced TRAIL-induced apoptosis. Oncol Rep. 2007 Sep;18(3):523-9.
• [243] Amiodarone sensitizes human glioma cells but not astrocytes to TRAIL-induced apoptosis via CHOP-mediated DR5 upregulation. Neuro Oncol. 2011 Mar;13(3):267-79. doi: 10.1093/neuonc/noq195. Epub 2011 Feb 3.
• [244] Novel functional view of the crocidolite asbestos-treated A549 human lung epithelial transcriptome reveals an intricate network of pathways with opposing functions. BMC Genomics. 2008 Aug 7;9:376.
• [245] Death receptor 5 regulation during selenium-mediated apoptosis in human prostate cancer cells. Cancer Biol Ther. 2002 May-Jun;1(3):287-90. doi: 10.4161/cbt.83.
• [246] Death receptor regulation and celecoxib-induced apoptosis in human lung cancer cells. J Natl Cancer Inst. 2004 Dec 1;96(23):1769-80. doi: 10.1093/jnci/djh322.
• [247] Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
• [248] Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
• [249] Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
• [250] Identification of biomarkers and outcomes of endocrine disruption in human ovarian cortex using In Vitro Models. Toxicology. 2023 Feb;485:153425. doi: 10.1016/j.tox.2023.153425. Epub 2023 Jan 5.
• [251] Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
• [252] Epidermal growth factor receptor signalling in human breast cancer cells operates parallel to estrogen receptor alpha signalling and results in tamoxifen insensitive proliferation. BMC Cancer. 2014 Apr 23;14:283.
• [253] Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
• [254] Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells. Eur J Pharmacol. 2014 Jun 5;732:60-7.
• [255] Aurora-A overexpression associates with Ha-ras codon-12 mutation and blackfoot disease endemic area in bladder cancer. Cancer Lett. 2006 Sep 8;241(1):93-101. doi: 10.1016/j.canlet.2005.10.014. Epub 2005 Dec 9.
• [256] Activation of nuclear factor-kappa B pathway by simvastatin and RhoA silencing increases doxorubicin cytotoxicity in human colon cancer HT29 cells. Mol Pharmacol. 2008 Aug;74(2):476-84.
• [257] A peptidyl-glucosamine derivative affects IKKalpha kinase activity in human chondrocytes. Arthritis Res Ther. 2010;12(1):R18. doi: 10.1186/ar2920. Epub 2010 Jan 29.
• [258] Arsenic trioxide exerts antimyeloma effects by inhibiting activity in the cytoplasmic substrates of histone deacetylase 6. PLoS One. 2012;7(2):e32215. doi: 10.1371/journal.pone.0032215. Epub 2012 Feb 22.
• [259] Constitutive activation of IkappaB kinase alpha and NF-kappaB in prostate cancer cells is inhibited by ibuprofen. Oncogene. 1999 Dec 2;18(51):7389-94. doi: 10.1038/sj.onc.1203160.
• [260] Antiepileptic drugs are endocrine disruptors for the human fetal testis ex vivo. Toxicol Sci. 2023 Sep 28;195(2):169-183. doi: 10.1093/toxsci/kfad076.
• [261] Chronic ethanol exposure increases goosecoid (GSC) expression in human embryonic carcinoma cell differentiation. J Appl Toxicol. 2014 Jan;34(1):66-75.
• [262] Rosiglitazone sensitizes MDA-MB-231 breast cancer cells to anti-tumour effects of tumour necrosis factor-alpha, CH11 and CYC202. Endocr Relat Cancer. 2007 Jun;14(2):305-15. doi: 10.1677/ERC-06-0003.
• [263] Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. PLoS One. 2012;7(12):e53003. doi: 10.1371/journal.pone.0053003. Epub 2012 Dec 27.
• [264] 17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.
• [265] Transcriptome dynamics of alternative splicing events revealed early phase of apoptosis induced by methylparaben in H1299 human lung carcinoma cells. Arch Toxicol. 2020 Jan;94(1):127-140. doi: 10.1007/s00204-019-02629-w. Epub 2019 Nov 20.
• [266] An in vitro strategy using multiple human induced pluripotent stem cell-derived models to assess the toxicity of chemicals: A case study on paraquat. Toxicol In Vitro. 2022 Jun;81:105333. doi: 10.1016/j.tiv.2022.105333. Epub 2022 Feb 16.
• [267] Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 Feb 26;10(1):3450. doi: 10.1038/s41598-020-59827-1.
• [268] The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
• [269] The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
• [270] Pleiotropic combinatorial transcriptomes of human breast cancer cells exposed to mixtures of dietary phytoestrogens. Food Chem Toxicol. 2009 Apr;47(4):787-95.
• [271] Inhibiting ubiquitination causes an accumulation of SUMOylated newly synthesized nuclear proteins at PML bodies. J Biol Chem. 2019 Oct 18;294(42):15218-15234. doi: 10.1074/jbc.RA119.009147. Epub 2019 Jul 8.
• [272] Bisphenol A Exposure Changes the Transcriptomic and Proteomic Dynamics of Human Retinoblastoma Y79 Cells. Genes (Basel). 2021 Feb 11;12(2):264. doi: 10.3390/genes12020264.
• [273] Gene expression profile analysis of gallic acid-induced cell death process. Sci Rep. 2021 Aug 18;11(1):16743. doi: 10.1038/s41598-021-96174-1.
• [274] mTOR inhibition reverses acquired endocrine therapy resistance of breast cancer cells at the cell proliferation and gene-expression levels. Cancer Sci. 2008 Oct;99(10):1992-2003. doi: 10.1111/j.1349-7006.2008.00955.x.
• [275] Leptomycin B reduces primary and acquired resistance of gefitinib in lung cancer cells. Toxicol Appl Pharmacol. 2017 Nov 15;335:16-27. doi: 10.1016/j.taap.2017.09.017. Epub 2017 Sep 21.
• [276] Assessment of the cytotoxic, genotoxic, and apoptotic potential of flurbiprofen in HeLa and HepG2 cell lines. J Biochem Mol Toxicol. 2021 Jun;35(6):1-11. doi: 10.1002/jbt.22770. Epub 2021 Mar 11.
• [277] Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
• [278] Bexarotene activates the p53/p73 pathway in human cutaneous T-cell lymphoma. Br J Dermatol. 2009 Mar;160(3):519-26. doi: 10.1111/j.1365-2133.2008.08931.x. Epub 2008 Nov 25.
• [279] Apoptotic induction by simvastatin in human lung cancer A549 cells via Akt signaling dependent down-regulation of survivin. Invest New Drugs. 2011 Oct;29(5):945-52. doi: 10.1007/s10637-010-9450-2. Epub 2010 May 13.
• [280] Combining lapatinib (GW572016), a small molecule inhibitor of ErbB1 and ErbB2 tyrosine kinases, with therapeutic anti-ErbB2 antibodies enhances apoptosis of ErbB2-overexpressing breast cancer cells. Oncogene. 2005 Sep 15;24(41):6213-21. doi: 10.1038/sj.onc.1208774.
• [281] Quercetin inhibit human SW480 colon cancer growth in association with inhibition of cyclin D1 and survivin expression through Wnt/beta-catenin signaling pathway. Cancer Invest. 2009 Jul;27(6):604-12. doi: 10.1080/07357900802337191.
• [282] Troglitazone sensitizes tumor cells to TRAIL-induced apoptosis via down-regulation of FLIP and Survivin. Apoptosis. 2006 Sep;11(9):1503-12. doi: 10.1007/s10495-006-8896-3.
• [283] Methotrexate normalizes up-regulated folate pathway genes in rheumatoid arthritis. Arthritis Rheum. 2013 Nov;65(11):2791-802.
• [284] Activation of beta-catenin signalling by GSK-3 inhibition increases p-glycoprotein expression in brain endothelial cells. J Neurochem. 2008 Aug;106(4):1855-65. doi: 10.1111/j.1471-4159.2008.05537.x. Epub 2008 Jul 4.
• [285] ATP binding cassette multidrug transporters limit the anti-HIV activity of zidovudine and indinavir in infected human macrophages. Antivir Ther. 2004 Aug;9(4):519-28.
• [286] Selenium-dependent and -independent transport of arsenic by the human multidrug resistance protein 2 (MRP2/ABCC2): implications for the mutual detoxification of arsenic and selenium. Carcinogenesis. 2010 Aug;31(8):1450-5. doi: 10.1093/carcin/bgq125. Epub 2010 Jun 27.
• [287] Hematopoietic stem cell differentiation affects expression and function of MRP4 (ABCC4), a transport protein for signaling molecules and drugs. Int J Cancer. 2009 May 15;124(10):2303-11. doi: 10.1002/ijc.24207.
• [288] Prolonged use of aspirin alters human and rat intestinal cells and thereby limits the absorption of clopidogrel. Clin Pharmacol Ther. 2011 Oct;90(4):612-9. doi: 10.1038/clpt.2011.163. Epub 2011 Sep 7.
• [289] The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites. Mol Cancer Ther. 2005 May;4(5):855-63.
• [290] ATP-binding cassette C transporters in human pancreatic carcinoma cell lines. Upregulation in 5-fluorouracil-resistant cells. Pancreatology. 2009;9(1-2):136-44.
• [291] Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
• [292] Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
• [293] Expression and transcriptional regulation of ABC transporters and cytochromes P450 in hCMEC/D3 human cerebral microvascular endothelial cells. Biochem Pharmacol. 2009 Mar 1;77(5):897-909.
• [294] Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
• [295] PGK1 induction by a hydrogen peroxide treatment is suppressed by antioxidants in human colon carcinoma cells. Biosci Biotechnol Biochem. 2008 Jul;72(7):1799-808. doi: 10.1271/bbb.80079. Epub 2008 Jul 7.
• [296] Peripheral blood expression of nuclear factor-kappab-regulated genes is associated with rheumatoid arthritis disease activity and responds differentially to anti-tumor necrosis factor-alpha versus methotrexate. J Rheumatol. 2007 Sep;34(9):1817-22. Epub 2007 Aug 1.
• [297] Combination of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and actinomycin D induces apoptosis even in TRAIL-resistant human pancreatic cancer cells. Clin Cancer Res. 2001 Feb;7(2):407-14.
• [298] Simvastatin induces apoptosis in human colon cancer cells and in tumor xenografts, and attenuates colitis-associated colon cancer in mice. Int J Cancer. 2008 Aug 15;123(4):951-7. doi: 10.1002/ijc.23593.
• [299] Rifampicin inhibits CD95-mediated apoptosis of Jurkat T cells via glucocorticoid receptors by modifying the expression of molecules regulating apoptosis. J Clin Immunol. 2002 Jan;22(1):37-47. doi: 10.1023/a:1014256603539.
• [300] Ethacrynic acid and a derivative enhance apoptosis in arsenic trioxide-treated myeloid leukemia and lymphoma cells: the role of glutathione S-transferase p1-1. Clin Cancer Res. 2012 Dec 15;18(24):6690-701. doi: 10.1158/1078-0432.CCR-12-0770. Epub 2012 Oct 18.
• [301] Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
• [302] Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma. Oncotarget. 2014 May 15;5(9):2355-71.
• [303] DHX15 is associated with poor prognosis in acute myeloid leukemia (AML) and regulates cell apoptosis via the NF-kB signaling pathway. Oncotarget. 2017 Aug 16;8(52):89643-89654. doi: 10.18632/oncotarget.20288. eCollection 2017 Oct 27.
• [304] Multi-level gene expression profiles affected by thymidylate synthase and 5-fluorouracil in colon cancer. BMC Genomics. 2006 Apr 3;7:68. doi: 10.1186/1471-2164-7-68.
• [305] Gene expression in endometrial cancer cells (Ishikawa) after short time high dose exposure to progesterone. Steroids. 2008 Jan;73(1):116-28.
• [306] Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. Arch Toxicol. 2018 Apr;92(4):1453-1469.
• [307] In vitro effects of aldehydes present in tobacco smoke on gene expression in human lung alveolar epithelial cells. Toxicol In Vitro. 2013 Apr;27(3):1072-81.
• [308] Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
• [309] Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
• [310] Monitoring of deiodinase deficiency based on transcriptomic responses in SH-SY5Y cells. Arch Toxicol. 2013 Jun;87(6):1103-13. doi: 10.1007/s00204-013-1018-4. Epub 2013 Feb 10.
• [311] Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92. doi: 10.1016/j.bbrc.2011.08.027. Epub 2011 Aug 16.
• [312] Ultradian cortisol pulsatility encodes a distinct, biologically important signal. PLoS One. 2011 Jan 18;6(1):e15766.
• [313] Effects of progesterone treatment on expression of genes involved in uterine quiescence. Reprod Sci. 2011 Aug;18(8):781-97.
• [314] Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
• [315] Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
• [316] New insights into BaP-induced toxicity: role of major metabolites in transcriptomics and contribution to hepatocarcinogenesis. Arch Toxicol. 2016 Jun;90(6):1449-58.
• [317] Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
• [318] Alcohol triggered bile acid disequilibrium by suppressing BSEP to sustain hepatocellular carcinoma progression. Chem Biol Interact. 2022 Apr 1;356:109847. doi: 10.1016/j.cbi.2022.109847. Epub 2022 Feb 9.
• [319] Bortezomib induces caspase-dependent apoptosis in Hodgkin lymphoma cell lines and is associated with reduced c-FLIP expression: a gene expression profiling study with implications for potential combination therapies. Leuk Res. 2008 Feb;32(2):275-85. doi: 10.1016/j.leukres.2007.05.024. Epub 2007 Jul 19.
• [320] Cdk4/6 inhibition induces epithelial-mesenchymal transition and enhances invasiveness in pancreatic cancer cells. Mol Cancer Ther. 2012 Oct;11(10):2138-48. doi: 10.1158/1535-7163.MCT-12-0562. Epub 2012 Aug 6.
• [321] Insights into the transcriptional regulation of the anthracycline reductase AKR7A2 in human cardiomyocytes. Toxicol Lett. 2019 Jun 1;307:11-16.
• [322] Apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma. PLoS One. 2011;6(8):e23569.
• [323] Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions. Toxicol In Vitro. 2009 Apr;23(3):466-75. doi: 10.1016/j.tiv.2008.12.018. Epub 2008 Dec 30.
• [324] Inducible protection of human astrocytoma 1321N1 cells against hydrogen peroxide and aldehyde toxicity by 7-hydroxycoumarin is associated with the upregulation of aldo-keto reductases. Neurotoxicology. 2012 Oct;33(5):1368-74.
• [325] Human aldo-keto reductase AKR7A2 protects against the cytotoxicity and mutagenicity of reactive aldehydes and lowers intracellular reactive oxygen species in hamster V79-4 cells. Chem Biol Interact. 2012 Jan 5;195(1):25-34. doi: 10.1016/j.cbi.2011.09.007. Epub 2011 Oct 5.
• [326] Selenium sensitizes MCF-7 breast cancer cells to doxorubicin-induced apoptosis through modulation of phospho-Akt and its downstream substrates. Mol Cancer Ther. 2007 Mar;6(3):1031-8. doi: 10.1158/1535-7163.MCT-06-0643. Epub 2007 Mar 5.
• [327] Combination small molecule MEK and PI3K inhibition enhances uveal melanoma cell death in a mutant GNAQ- and GNA11-dependent manner. Clin Cancer Res. 2012 Aug 15;18(16):4345-55. doi: 10.1158/1078-0432.CCR-11-3227. Epub 2012 Jun 25.
• [328] Quercetin induced cell apoptosis and altered gene expression in AGS human gastric cancer cells. Environ Toxicol. 2018 Nov;33(11):1168-1181. doi: 10.1002/tox.22623. Epub 2018 Aug 27.
• [329] An in vitro study on anti-carcinogenic effect of remdesivir in human ovarian cancer cells via generation of reactive oxygen species. Hum Exp Toxicol. 2022 Jan-Dec;41:9603271221089257. doi: 10.1177/09603271221089257.
• [330] Antitumor action of the MET tyrosine kinase inhibitor crizotinib (PF-02341066) in gastric cancer positive for MET amplification. Mol Cancer Ther. 2012 Jul;11(7):1557-64. doi: 10.1158/1535-7163.MCT-11-0934. Epub 2012 Jun 22.
• [331] Arsenic trioxide induces different gene expression profiles of genes related to growth and apoptosis in glioma cells dependent on the p53 status. Mol Biol Rep. 2008 Sep;35(3):421-9.
• [332] Aspirin induces apoptosis in human leukemia cells independently of NF-kappaB and MAPKs through alteration of the Mcl-1/Noxa balance. Apoptosis. 2010 Feb;15(2):219-29. doi: 10.1007/s10495-009-0424-9.
• [333] Effects of all-trans and 9-cis retinoic acid on differentiating human neural stem cells in vitro. Toxicology. 2023 Mar 15;487:153461. doi: 10.1016/j.tox.2023.153461. Epub 2023 Feb 16.
• [334] Neuronal and cardiac toxicity of pharmacological compounds identified through transcriptomic analysis of human pluripotent stem cell-derived embryoid bodies. Toxicol Appl Pharmacol. 2021 Dec 15;433:115792. doi: 10.1016/j.taap.2021.115792. Epub 2021 Nov 3.
• [335] Molecular mechanisms of resveratrol action in lung cancer cells using dual protein and microarray analyses. Cancer Res. 2007 Dec 15;67(24):12007-17. doi: 10.1158/0008-5472.CAN-07-2464.
• [336] Glyphosate-based herbicide induces long-lasting impairment in neuronal and glial differentiation. Environ Toxicol. 2022 Aug;37(8):2044-2057. doi: 10.1002/tox.23549. Epub 2022 Apr 29.
• [337] Manganese superoxide dismutase induces migration and invasion of tongue squamous cell carcinoma via H2O2-dependent Snail signaling. Free Radic Biol Med. 2012 Jul 1;53(1):44-50. doi: 10.1016/j.freeradbiomed.2012.04.031. Epub 2012 May 9.
• [338] Ciprofloxacin mediates cancer stem cell phenotypes in lung cancer cells through caveolin-1-dependent mechanism. Chem Biol Interact. 2016 Apr 25;250:1-11.
• [339] Endoplasmic reticulum stress contributes to arsenic trioxide-induced intrinsic apoptosis in human umbilical and bone marrow mesenchymal stem cells. Environ Toxicol. 2016 Mar;31(3):314-28.
• [340] Development and validation of the TGx-HDACi transcriptomic biomarker to detect histone deacetylase inhibitors in human TK6 cells. Arch Toxicol. 2021 May;95(5):1631-1645. doi: 10.1007/s00204-021-03014-2. Epub 2021 Mar 26.
• [341] The thioxotriazole copper(II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cells. J Biol Chem. 2009 Sep 4;284(36):24306-19.
• [342] Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
• [343] Gene expression changes associated with cytotoxicity identified using cDNA arrays. Funct Integr Genomics. 2000 Sep;1(2):114-26.
• [344] Analysis of the transcriptional regulation of cancer-related genes by aberrant DNA methylation of the cis-regulation sites in the promoter region during hepatocyte carcinogenesis caused by arsenic. Oncotarget. 2015 Aug 28;6(25):21493-506. doi: 10.18632/oncotarget.4085.
• [345] Exploring pradimicin-IRD antineoplastic mechanisms and related DNA repair pathways. Chem Biol Interact. 2023 Feb 1;371:110342. doi: 10.1016/j.cbi.2023.110342. Epub 2023 Jan 10.
• [346] Regulation of lipocalin-2 gene by the cancer chemopreventive retinoid 4-HPR. Int J Cancer. 2006 Oct 1;119(7):1599-606.
• [347] A high concentration of genistein down-regulates activin A, Smad3 and other TGF-beta pathway genes in human uterine leiomyoma cells. Exp Mol Med. 2012 Apr 30;44(4):281-92.
• [348] Genome-wide functional screen identifies a compendium of genes affecting sensitivity to tamoxifen. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2730-5. doi: 10.1073/pnas.1018872108. Epub 2011 Apr 11.
• [349] Selective inhibition of BET bromodomains. Nature. 2010 Dec 23;468(7327):1067-73.
• [350] Nucleoside reverse transcriptase inhibitors induce a mitophagy-associated endothelial cytotoxicity that is reversed by coenzyme Q10 cotreatment. Toxicol Sci. 2013 Aug;134(2):323-34. doi: 10.1093/toxsci/kft105. Epub 2013 May 2.
• [351] Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
• [352] Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mitochondrial cell death protein BNIP3. Oncogene. 2005 Feb 3;24(6):980-91. doi: 10.1038/sj.onc.1208095.
• [353] The NRF2-mediated oxidative stress response pathway is associated with tumor cell resistance to arsenic trioxide across the NCI-60 panel. BMC Med Genomics. 2010 Aug 13;3:37. doi: 10.1186/1755-8794-3-37.
• [354] Gene expression changes in primary human nasal epithelial cells exposed to formaldehyde in vitro. Toxicol Lett. 2010 Oct 5;198(2):289-95.
• [355] A trichostatin A expression signature identified by TempO-Seq targeted whole transcriptome profiling. PLoS One. 2017 May 25;12(5):e0178302. doi: 10.1371/journal.pone.0178302. eCollection 2017.
• [356] Gene expression signatures after ethanol exposure in differentiating embryoid bodies. Toxicol In Vitro. 2018 Feb;46:66-76.
• [357] Microarray analyses in dendritic cells reveal potential biomarkers for chemical-induced skin sensitization. Mol Immunol. 2007 May;44(12):3222-33.
• [358] Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
• [359] Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297. doi: 10.1016/j.fct.2020.111297. Epub 2020 Mar 28.
• [360] Association of Arsenic Exposure with Whole Blood DNA Methylation: An Epigenome-Wide Study of Bangladeshi Adults. Environ Health Perspect. 2019 May;127(5):57011. doi: 10.1289/EHP3849. Epub 2019 May 28.
• [361] Gene expression profile analysis of 4-phenylbutyrate treatment of IB3-1 bronchial epithelial cell line demonstrates a major influence on heat-shock proteins. Physiol Genomics. 2004 Jan 15;16(2):204-11.
• [362] Gene expression profiling of rheumatoid arthritis synovial cells treated with antirheumatic drugs. J Biomol Screen. 2007 Apr;12(3):328-40. doi: 10.1177/1087057107299261. Epub 2007 Mar 22.
• [363] Cyclosporine A--induced oxidative stress in human renal mesangial cells: a role for ERK 1/2 MAPK signaling. Toxicol Sci. 2012 Mar;126(1):101-13.
• [364] Proteomic analysis of anti-cancer effects by paclitaxel treatment in cervical cancer cells. Gynecol Oncol. 2005 Jul;98(1):45-53. doi: 10.1016/j.ygyno.2005.04.010.
• [365] A genome-wide analysis of targets of macrolide antibiotics in mammalian cells. J Biol Chem. 2020 Feb 14;295(7):2057-2067. doi: 10.1074/jbc.RA119.010770. Epub 2020 Jan 8.
• [366] Alternatives for the worse: Molecular insights into adverse effects of bisphenol a and substitutes during human adipocyte differentiation. Environ Int. 2021 Nov;156:106730. doi: 10.1016/j.envint.2021.106730. Epub 2021 Jun 27.
• [367] Sulindac activates nuclear translocation of AIF, DFF40 and endonuclease G but not induces oligonucleosomal DNA fragmentation in HT-29 cells. Life Sci. 2005 Sep 2;77(16):2059-70. doi: 10.1016/j.lfs.2005.04.021.
• [368] Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
• [369] SOX30, a novel epigenetic silenced tumor suppressor, promotes tumor cell apoptosis by transcriptional activating p53 in lung cancer. Oncogene. 2015 Aug 13;34(33):4391-402. doi: 10.1038/onc.2014.370. Epub 2014 Dec 1.
• [370] CyclinB2 and BIRC5 genes as surrogate biomarkers for neurite outgrowth in SH-SY5Y subclonal cells. Neuropharmacology. 2006 Jun;50(8):1041-7. doi: 10.1016/j.neuropharm.2006.02.004. Epub 2006 Mar 30.
• [371] Effects of chlorpromazine with and without UV irradiation on gene expression of HepG2 cells. Mutat Res. 2005 Aug 4;575(1-2):47-60. doi: 10.1016/j.mrfmmm.2005.03.002. Epub 2005 Apr 26.
• [372] Inflammation in methotrexate-induced pulmonary toxicity occurs via the p38 MAPK pathway. Toxicology. 2009 Feb 27;256(3):183-90. doi: 10.1016/j.tox.2008.11.016. Epub 2008 Nov 28.
• [373] Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons. PLoS One. 2009 Sep 23;4(9):e7155.
• [374] Prostate-derived Ets transcription factor as a favorable prognostic marker in ovarian cancer patients. Int J Cancer. 2008 Sep 15;123(6):1376-84. doi: 10.1002/ijc.23667.
• [375] Using DNA microarray analyses to elucidate the effects of genistein in androgen-responsive prostate cancer cells: identification of novel targets. Mol Carcinog. 2004 Oct;41(2):108-119.
• [376] CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.
• [377] Effects of Wood Smoke Constituents on Mucin Gene Expression in Mice and Human Airway Epithelial Cells and on Nasal Epithelia of Subjects with a Susceptibility Gene Variant in Tp53. Environ Health Perspect. 2022 Jan;130(1):17010. doi: 10.1289/EHP9446. Epub 2022 Jan 24.
• [378] Drinking-water arsenic exposure modulates gene expression in human lymphocytes from a U.S. population. Environ Health Perspect. 2008 Apr;116(4):524-31. doi: 10.1289/ehp.10861.
• [379] Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner. Carcinogenesis. 2009 Aug;30(8):1320-9. doi: 10.1093/carcin/bgp138. Epub 2009 Jun 5.
• [380] Quercetin suppresses pancreatic ductal adenocarcinoma progression via inhibition of SHH and TGF-/Smad signaling pathways. Cell Biol Toxicol. 2021 Jun;37(3):479-496. doi: 10.1007/s10565-020-09562-0. Epub 2020 Oct 17.
• [381] Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
• [382] Inhibition of the cancer stem cells-like properties by arsenic trioxide, involved in the attenuation of endogenous transforming growth factor beta signal. Toxicol Sci. 2015 Jan;143(1):156-64. doi: 10.1093/toxsci/kfu218. Epub 2014 Oct 10.
• [383] In vitro antitumoral effects of the steroid ouabain on human thyroid papillary carcinoma cell lines. Environ Toxicol. 2021 Jul;36(7):1338-1348. doi: 10.1002/tox.23130. Epub 2021 Mar 24.
• [384] Aldosterone induces epithelial-mesenchymal transition via ROS of mitochondrial origin. Am J Physiol Renal Physiol. 2007 Sep;293(3):F723-31. doi: 10.1152/ajprenal.00480.2006. Epub 2007 Jun 27.
• [385] Analysis of the in vitro synergistic effect of 5-fluorouracil and cisplatin on cervical carcinoma cells. Int J Gynecol Cancer. 2006 May-Jun;16(3):1321-9.
• [386] Exposure to Insecticides Modifies Gene Expression and DNA Methylation in Hematopoietic Tissues In Vitro. Int J Mol Sci. 2023 Mar 26;24(7):6259. doi: 10.3390/ijms24076259.
• [387] Inhibition of prostate cancer cell colony formation by the flavonoid quercetin correlates with modulation of specific regulatory genes. Clin Diagn Lab Immunol. 2004 Jan;11(1):63-9. doi: 10.1128/cdli.11.1.63-69.2004.
• [388] Zidovudine induces S-phase arrest and cell cycle gene expression changes in human cells. Mutagenesis. 2005 Mar;20(2):139-46. doi: 10.1093/mutage/gei019. Epub 2005 Mar 22.
• [389] Mechanism of cisplatin proximal tubule toxicity revealed by integrating transcriptomics, proteomics, metabolomics and biokinetics. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):117-27.
• [390] Cytotoxic Effects of Cannabinoids on Human HT-29 Colorectal Adenocarcinoma Cells: Different Mechanisms of THC, CBD, and CB83. Int J Mol Sci. 2020 Aug 1;21(15):5533. doi: 10.3390/ijms21155533.
• [391] Comparison of characteristics of peroxide-conditioned immortal human lens-epithelial cell lines with their murine counterparts. Exp Eye Res. 2004 Sep;79(3):411-7.
• [392] Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways. Food Chem Toxicol. 2021 Dec;158:112664. doi: 10.1016/j.fct.2021.112664. Epub 2021 Nov 9.
• [393] Quercetin modulates Nrf2 and glutathione-related defenses in HepG2 cells: Involvement of p38. Chem Biol Interact. 2012 Jan 25;195(2):154-64.
• [394] Glutathione depletion in antioxidant defense of differentiated NT2-LHON cybrids. Neurobiol Dis. 2007 Mar;25(3):536-44.
• [395] An approach to elucidate potential mechanism of renal toxicity of arsenic trioxide. Exp Hematol. 2007 Feb;35(2):252-62.
• [396] CRISPR/Cas9-mediated gene knockout screens and target identification via whole-genome sequencing uncover host genes required for picornavirus infection. J Biol Chem. 2017 Jun 23;292(25):10664-10671. doi: 10.1074/jbc.M117.782425. Epub 2017 Apr 26.
• [397] Pro-oxidant induced DNA damage in human lymphoblastoid cells: homeostatic mechanisms of genotoxic tolerance. Toxicol Sci. 2012 Aug;128(2):387-97. doi: 10.1093/toxsci/kfs152. Epub 2012 Apr 26.
• [398] Delivery method, target gene structure, and growth properties of target cells impact mutagenic responses to reactive nitrogen and oxygen species. Chem Res Toxicol. 2012 Apr 16;25(4):873-83. doi: 10.1021/tx2004882. Epub 2012 Feb 21.
• [399] Non-nutritional sweeteners effects on endothelial vascular function. Toxicol In Vitro. 2020 Feb;62:104694. doi: 10.1016/j.tiv.2019.104694. Epub 2019 Oct 23.
• [400] Genotoxicity of 3'-azido-3'-deoxythymidine in the human lymphoblastoid cell line, TK6: relationships between DNA incorporation, mutant frequency, and spectrum of deletion mutations in HPRT. Mutat Res. 1999 Oct 19;429(2):249-59. doi: 10.1016/s0027-5107(99)00111-6.
• [401] Cysteine mapping in conformationally distinct kinase nucleotide binding sites: application to the design of selective covalent inhibitors. J Med Chem. 2011 Mar 10;54(5):1347-55. doi: 10.1021/jm101396q. Epub 2011 Feb 15.
• [402] Dasatinib (BMS-354825) selectively induces apoptosis in lung cancer cells dependent on epidermal growth factor receptor signaling for survival. Cancer Res. 2006 Jun 1;66(11):5542-8. doi: 10.1158/0008-5472.CAN-05-4620.
• [403] Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 2004 May 20;350(21):2129-39. doi: 10.1056/NEJMoa040938. Epub 2004 Apr 29.
• [404] The dual ErbB1/ErbB2 inhibitor, lapatinib (GW572016), cooperates with tamoxifen to inhibit both cell proliferation- and estrogen-dependent gene expression in antiestrogen-resistant breast cancer. Cancer Res. 2005 Jan 1;65(1):18-25.
• [405] A fine-needle aspirate-based vulnerability assay identifies polo-like kinase 1 as a mediator of gemcitabine resistance in pancreatic cancer. Mol Cancer Ther. 2010 Feb;9(2):311-8. doi: 10.1158/1535-7163.MCT-09-0693. Epub 2010 Jan 26.
• [406] Prediction of chemosensitivity using multigene analysis in head and neck squamous cell carcinoma. Oncology. 2007;73(1-2):104-11. doi: 10.1159/000120998. Epub 2008 Mar 13.
• [407] Ligand-dependent activation of the epidermal growth factor receptor by secondary bile acids in polarizing colon cancer cells. Surgery. 2005 Sep;138(3):415-21. doi: 10.1016/j.surg.2005.06.030.
• [408] Consequences of the natural retinoid/retinoid X receptor ligands action in human breast cancer MDA-MB-231 cell line: Focus on functional proteomics. Toxicol Lett. 2017 Nov 5;281:26-34. doi: 10.1016/j.toxlet.2017.09.001. Epub 2017 Sep 5.
• [409] Genomic and proteomic analysis of the effects of cannabinoids on normal human astrocytes. Brain Res. 2008 Jan 29;1191:1-11.
• [410] Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells. Toxicol Sci. 2011 Mar;120(1):109-22.
• [411] Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21.
• [412] Comparison of the gene expression profiles of monocytic versus granulocytic lineages of HL-60 leukemia cell differentiation by DNA microarray analysis. Life Sci. 2003 Aug 15;73(13):1705-19. doi: 10.1016/s0024-3205(03)00515-0.
• [413] Role of NADPH oxidase in arsenic-induced reactive oxygen species formation and cytotoxicity in myeloid leukemia cells. Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4578-83.
• [414] Acetaminophen-induced proliferation of estrogen-responsive breast cancer cells is associated with increases in c-myc RNA expression and NF-kappaB activity. Toxicol Sci. 2002 Apr;66(2):233-43. doi: 10.1093/toxsci/66.2.233.
• [415] ZD1839 induces p15INK4b and causes G1 arrest by inhibiting the mitogen-activated protein kinase/extracellular signal-regulated kinase pathway. Mol Cancer Ther. 2007 May;6(5):1579-87. doi: 10.1158/1535-7163.MCT-06-0814.
• [416] Selenite and selenomethionine promote HL-60 cell cycle progression. J Nutr. 2002 Apr;132(4):674-9. doi: 10.1093/jn/132.4.674.
• [417] Ribavirin augments doxorubicin's efficacy in human hepatocellular carcinoma through inhibiting doxorubicin-induced eIF4E activation. J Biochem Mol Toxicol. 2018 Jan;32(1). doi: 10.1002/jbt.22007. Epub 2017 Nov 7.
• [418] Novel detection and differential utilization of a c-myc transcriptional block in colon cancer chemoprevention. Cancer Res. 2002 Nov 1;62(21):6006-10.
• [419] Quercetin inhibits p21-RAS expression in human colon cancer cell lines and in primary colorectal tumors. Int J Cancer. 2000 Feb 1;85(3):438-45.
• [420] Poly(ADP-ribosyl)ation enhances H-RAS protein stability and causes abnormal cell cycle progression in human TK6 lymphoblastoid cells treated with hydroquinone. Chem Biol Interact. 2015 Aug 5;238:1-8. doi: 10.1016/j.cbi.2015.05.019. Epub 2015 Jun 3.
• [421] Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNF-mediated hepatotoxicity. Toxicol Sci. 2014 Jul;140(1):144-59. doi: 10.1093/toxsci/kfu072. Epub 2014 Apr 20.
• [422] Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Redox Biol. 2020 Jan;28:101321. doi: 10.1016/j.redox.2019.101321. Epub 2019 Sep 5.
• [423] Ramipril inhibits in vitro human mesangial cell proliferation and platelet-derived growth factor expression. Exp Nephrol. 1999 May-Jun;7(3):229-35. doi: 10.1159/000020606.
• [424] Simvastatin inhibits PDGF-induced DNA synthesis in human glomerular mesangial cells. Kidney Int. 1993 Sep;44(3):503-8. doi: 10.1038/ki.1993.274.
• [425] Alcohol and Cannabinoids Differentially Affect HIV Infection and Function of Human Monocyte-Derived Dendritic Cells (MDDC). Front Microbiol. 2015 Dec 22;6:1452. doi: 10.3389/fmicb.2015.01452. eCollection 2015.
• [426] Chemosensitization by STI571 targeting the platelet-derived growth factor/platelet-derived growth factor receptor-signaling pathway in the tumor progression and angiogenesis of gastric carcinoma. Cancer. 2005 May 1;103(9):1800-9. doi: 10.1002/cncr.20973.
• [427] Oxidative stress in kidney transplant patients with calcineurin inhibitor-induced hypertension: effect of ramipril. J Cardiovasc Pharmacol. 2002 Oct;40(4):625-31.
• [428] Antiestrogens induce transforming growth factor beta-mediated immunosuppression in breast cancer. Cancer Res. 2010 Feb 15;70(4):1314-22. doi: 10.1158/0008-5472.CAN-09-3292. Epub 2010 Feb 9.
• [429] PPAR-alpha ligands inhibit H2O2-mediated activation of transforming growth factor-beta1 in human mesangial cells. Antioxid Redox Signal. 2002 Dec;4(6):877-84. doi: 10.1089/152308602762197416.
• [430] Cannabidiol selectively modulates interleukin (IL)-1 and IL-6 production in toll-like receptor activated human peripheral blood monocytes. Toxicology. 2021 Dec;464:153016. doi: 10.1016/j.tox.2021.153016. Epub 2021 Nov 2.
• [431] Cytokine abnormalities in a patient with eosinophilic fasciitis. Ann Allergy Asthma Immunol. 2003 Apr;90(4):452-5. doi: 10.1016/S1081-1206(10)61832-7.
• [432] Ciprofloxacin decreases survival in HT-29 cells via the induction of TGF-beta1 secretion and enhances the anti-proliferative effect of 5-fluorouracil. Br J Pharmacol. 2009 Jun;157(3):362-70. doi: 10.1111/j.1476-5381.2009.00161.x. Epub 2009 Apr 9.
• [433] Enhanced apoptosis and transforming growth factor-beta1 expression in colorectal adenomas and carcinomas after Sulindac therapy. Dis Colon Rectum. 2001 Jul;44(7):1008-15. doi: 10.1007/BF02235490.
• [434] Fumarate Mediates a Chronic Proliferative Signal in Fumarate Hydratase-Inactivated Cancer Cells by Increasing Transcription and Translation of Ferritin Genes. Mol Cell Biol. 2017 May 16;37(11):e00079-17. doi: 10.1128/MCB.00079-17. Print 2017 Jun 1.
• [435] Keratinocyte gene expression profiles discriminate sensitizing and irritating compounds. Toxicol Sci. 2010 Sep;117(1):81-9.
• [436] Comparison of replicative senescence and stress-induced premature senescence combining differential display and low-density DNA arrays. FEBS Lett. 2005 Jul 4;579(17):3651-9. doi: 10.1016/j.febslet.2005.05.056.
• [437] Growth-suppressive effect of non-steroidal anti-inflammatory drugs on 11 colon-cancer cell lines and fluorescence differential display of genes whose expression is influenced by sulindac. Int J Cancer. 2000 Dec 15;88(6):873-80. doi: 10.1002/1097-0215(20001215)88:6<873::aid-ijc6>3.0.co;2-b.
• [438] [Construction of subtracted cDNA library in human Jurkat T cell line induced by arsenic trioxide in vitro]. Zhonghua Yu Fang Yi Xue Za Zhi. 2003 Nov;37(6):403-7.
• [439] Survival of retinal pigment epithelium after exposure to prolonged oxidative injury: a detailed gene expression and cellular analysis. Invest Ophthalmol Vis Sci. 2004 Oct;45(10):3767-77.
• [440] Expression pattern of cisplatin-induced metallothionein isoforms in squamous cell carcinoma. Anticancer Res. 2003 Jan-Feb;23(1A):299-303.
• [441] Identification of novel activators of the metal responsive transcription factor (MTF-1) using a gene expression biomarker in a microarray compendium. Metallomics. 2020 Sep 23;12(9):1400-1415. doi: 10.1039/d0mt00071j.
• [442] Expression of antioxidant proteins in human intestinal Caco-2 cells treated with dietary flavonoids. Cancer Lett. 1999 Nov 15;146(2):161-7.
• [443] JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Oncogene. 2008 Aug 28;27(37):5033-44.
• [444] Mutation in mitochondrial complex I ND6 subunit is associated with defective response to hypoxia in human glioma cells. Mol Cancer. 2004 Jul 12;3:19. doi: 10.1186/1476-4598-3-19.
• [445] Persistent and non-persistent changes in gene expression result from long-term estrogen exposure of MCF-7 breast cancer cells. J Steroid Biochem Mol Biol. 2011 Feb;123(3-5):140-50.
• [446] Comparative effects of microtubules disruption on glucocorticoid receptor functions in proliferating and quiescent cells. Int J Toxicol. 2010 May-Jun;29(3):326-35. doi: 10.1177/1091581810366486.
• [447] Adipocyte differentiation, mitochondrial gene expression and fat distribution: differences between zidovudine and tenofovir after 6 months. Antivir Ther. 2009;14(8):1089-100. doi: 10.3851/IMP1457.
• [448] Arsenic trioxide induces cell cycle arrest and affects Trk receptor expression in human neuroblastoma SK-N-SH cells. Biol Res. 2018 Jun 13;51(1):18. doi: 10.1186/s40659-018-0167-6.
• [449] Evaluation of mRNA markers in differentiating human SH-SY5Y cells for estimation of developmental neurotoxicity. Neurotoxicology. 2023 Jul;97:65-77. doi: 10.1016/j.neuro.2023.05.011. Epub 2023 May 18.
• [450] Effect of cell differentiation for neuroblastoma by vitamin k analogs. Jpn J Clin Oncol. 2009 Apr;39(4):251-9. doi: 10.1093/jjco/hyp011. Epub 2009 Mar 8.
• [451] Long term effects of cigarette smoke extract or nicotine on nerve growth factor and its receptors in a bronchial epithelial cell line. Toxicol In Vitro. 2018 Dec;53:29-36. doi: 10.1016/j.tiv.2018.07.020. Epub 2018 Aug 1.
• [452] p53-R175H mutant gains new function in regulation of doxorubicin-induced apoptosis. Int J Cancer. 2005 Apr 10;114(3):331-6. doi: 10.1002/ijc.20818.
• [453] Azidothymidine and cisplatin increase p14ARF expression in OVCAR-3 ovarian cancer cell line. Toxicol Appl Pharmacol. 2006 Oct 1;216(1):89-97. doi: 10.1016/j.taap.2006.04.015. Epub 2006 May 19.
• [454] Quantitative analysis of gene expression changes in response to genotoxic compounds. Toxicol In Vitro. 2017 Mar;39:15-28. doi: 10.1016/j.tiv.2016.11.004. Epub 2016 Nov 5.
• [455] Gallic acid potentiates the apoptotic effect of paclitaxel and carboplatin via overexpression of Bax and P53 on the MCF-7 human breast cancer cell line. J Biochem Mol Toxicol. 2021 Feb;35(2):e22638. doi: 10.1002/jbt.22638. Epub 2020 Oct 1.
• [456] Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage. Nucleic Acids Res. 2009 Jan;37(1):78-95. doi: 10.1093/nar/gkn910. Epub 2008 Nov 16.
• [457] Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget. 2019 Jan 1;10(1):45-59. doi: 10.18632/oncotarget.26534. eCollection 2019 Jan 1.
• [458] Nitrogen Mustard Alkylates and Cross-Links p53 in Human Keratinocytes. Chem Res Toxicol. 2022 Apr 18;35(4):636-650. doi: 10.1021/acs.chemrestox.1c00420. Epub 2022 Mar 21.
• [459] Fulvestrant induces resistance by modulating GPER and CDK6 expression: implication of methyltransferases, deacetylases and the hSWI/SNF chromatin remodelling complex. Br J Cancer. 2013 Nov 12;109(10):2751-62. doi: 10.1038/bjc.2013.583. Epub 2013 Oct 29.
• [460] Inhibiting Heat Shock Proteins Can Potentiate the Cytotoxic Effect of Cannabidiol in Human Glioma Cells. Anticancer Res. 2015 Nov;35(11):5827-37.
• [461] Arsenic trioxide (ATO) influences the gene expression of metallothioneins in human glioblastoma cells. Biol Trace Elem Res. 2012 Dec;149(3):331-9.
• [462] Motexafin gadolinium disrupts zinc metabolism in human cancer cell lines. Cancer Res. 2005 May 1;65(9):3837-45.
• [463] Computational discovery of niclosamide ethanolamine, a repurposed drug candidate that reduces growth of hepatocellular carcinoma cells initro and in mice by inhibiting cell division cycle 37 signaling. Gastroenterology. 2017 Jun;152(8):2022-2036.
• [464] Glucocorticoids inhibit cell death in ovarian cancer and up-regulate caspase inhibitor cIAP2. Clin Cancer Res. 2005 Sep 1;11(17):6325-32. doi: 10.1158/1078-0432.CCR-05-0182.
• [465] Capturing time-dependent activation of genes and stress-response pathways using transcriptomics in iPSC-derived renal proximal tubule cells. Cell Biol Toxicol. 2023 Aug;39(4):1773-1793. doi: 10.1007/s10565-022-09783-5. Epub 2022 Dec 31.
• [466] Effects of Imatinib Mesylate (Gleevec) on human islet NF-kappaB activation and chemokine production in vitro. PLoS One. 2011;6(9):e24831. doi: 10.1371/journal.pone.0024831. Epub 2011 Sep 14.
• [467] Propofol suppresses proliferation, migration, invasion, and tumor growth of liver cancer cells via suppressing cancer susceptibility candidate 9/phosphatase and tensin homolog/AKT serine/threonine kinase/mechanistic target of rapamycin kinase axis. Hum Exp Toxicol. 2022 Jan-Dec;41:9603271211065972. doi: 10.1177/09603271211065972.
• [468] CXCL14 downregulation in human keratinocytes is a potential biomarker for a novel in vitro skin sensitization test. Toxicol Appl Pharmacol. 2020 Jan 1;386:114828. doi: 10.1016/j.taap.2019.114828. Epub 2019 Nov 14.
• [469] Proteomics-based identification of differentially abundant proteins from human keratinocytes exposed to arsenic trioxide. J Proteomics Bioinform. 2014 Jul;7(7):166-178.
• [470] Proteomic profile of aminoglutethimide-induced apoptosis in HL-60 cells: role of myeloperoxidase and arylamine free radicals. Chem Biol Interact. 2015 Sep 5;239:129-38.
• [471] The stability of cytokeratin 18 in human liver cells during colchicine-induced microtubule disruption. Food Chem Toxicol. 2001 Jan;39(1):85-9. doi: 10.1016/s0278-6915(00)00113-7.
• [472] Proteomic identification of differentially expressed proteins associated with the multiple drug resistance in methotrexate-resistant human breast cancer cells. Int J Oncol. 2014 Jul;45(1):448-58.
• [473] Identification of biomarkers for the initiation of apoptosis in human preneoplastic colonocytes by proteome analysis. Int J Cancer. 2004 Mar 20;109(2):220-9. doi: 10.1002/ijc.11692.
• [474] Nevirapine restores androgen signaling in hormone-refractory human prostate carcinoma cells both in vitro and in vivo. Prostate. 2009 May 15;69(7):744-54. doi: 10.1002/pros.20923.
• [475] Role of protein kinase D1 in vasoconstriction and haemodynamics in rats. Microvasc Res. 2024 Mar;152:104627. doi: 10.1016/j.mvr.2023.104627. Epub 2023 Nov 12.
• [476] The effects of dasatinib on IgE receptor-dependent activation and histamine release in human basophils. Blood. 2008 Mar 15;111(6):3097-107.
• [477] Comparative gene expression analysis of a chronic myelogenous leukemia cell line resistant to cyclophosphamide using oligonucleotide arrays and response to tyrosine kinase inhibitors. Leuk Res. 2007 Nov;31(11):1511-20.
• [478] Positive signaling interactions between arsenic and ethanol for angiogenic gene induction in human microvascular endothelial cells. Toxicol Sci. 2008 Apr;102(2):319-27. doi: 10.1093/toxsci/kfn003. Epub 2008 Jan 8.
• [479] Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
• [480] Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray. Cancer Sci. 2006 Jan;97(1):64-71.
• [481] Indomethacin inhibits cell growth of medullary thyroid carcinoma by reducing cell cycle progression into S phase. Exp Biol Med (Maywood). 2008 Nov;233(11):1433-40. doi: 10.3181/0804-RM-127. Epub 2008 Sep 12.
• [482] Therapeutically activating RB: reestablishing cell cycle control in endocrine therapy-resistant breast cancer. Endocr Relat Cancer. 2011 Apr 28;18(3):333-45. doi: 10.1530/ERC-10-0262. Print 2011 Jun.
• [483] BMN 673 (talazoparib): A potent PARP inhibitor for triple negative breast cancer with different genetic profile. J Biochem Mol Toxicol. 2019 May;33(5):e22286. doi: 10.1002/jbt.22286. Epub 2019 Jan 23.
• [484] Sulindac induces specific degradation of the HPV oncoprotein E7 and causes growth arrest and apoptosis in cervical carcinoma cells. Cancer Lett. 2007 Jan 8;245(1-2):103-11. doi: 10.1016/j.canlet.2005.12.034. Epub 2006 Feb 20.
• [485] HMG-CoA reductase inhibitor simvastatin inhibits cell cycle progression at the G1/S checkpoint in immortalized lymphocytes from Alzheimer's disease patients independently of cholesterol-lowering effects. J Pharmacol Exp Ther. 2008 Jan;324(1):352-9. doi: 10.1124/jpet.107.128959. Epub 2007 Oct 10.
• [486] G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently. J Biol Chem. 1993 Apr 15;268(11):8298-308.
• [487] Differential gene expression of sulindac-treated human breast epithelial cells. Int J Oncol. 2005 Dec;27(6):1727-36.
• [488] Quantitative proteomic analysis of HepG2 cells treated with quercetin suggests IQGAP1 involved in quercetin-induced regulation of cell proliferation and migration. OMICS. 2009 Apr;13(2):93-103. doi: 10.1089/omi.2008.0075.
• [489] Nucleophosmin acts as a novel AP2alpha-binding transcriptional corepressor during cell differentiation. EMBO Rep. 2007 Apr;8(4):394-400. doi: 10.1038/sj.embor.7400909. Epub 2007 Feb 23.
• [490] A role for the autophagy regulator Transcription Factor EB in amiodarone-induced phospholipidosis. Biochem Pharmacol. 2015 Jun 1;95(3):201-9. doi: 10.1016/j.bcp.2015.03.017. Epub 2015 Apr 13.
• [491] Proteomic analysis of the cellular response to a potent sensitiser unveils the dynamics of haptenation in living cells. Toxicology. 2020 Dec 1;445:152603. doi: 10.1016/j.tox.2020.152603. Epub 2020 Sep 28.
• [492] Marine biogenics in sea spray aerosols interact with the mTOR signaling pathway. Sci Rep. 2019 Jan 24;9(1):675.
• [493] Characterisation of human histone H1x. Biol Chem. 2005 Jun;386(6):541-51. doi: 10.1515/BC.2005.064.
• [494] Resveratrol modulates the phosphoinositide 3-kinase pathway through an estrogen receptor alpha-dependent mechanism: relevance in cell proliferation. Int J Cancer. 2004 Mar 20;109(2):167-73. doi: 10.1002/ijc.11720.
• [495] The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells. J Biol Chem. 2004 Jun 25;279(26):27008-16. doi: 10.1074/jbc.M403588200. Epub 2004 Apr 16.
• [496] Glucosamine sulfate-induced apoptosis in chronic myelogenous leukemia K562 cells is associated with translocation of cathepsin D and downregulation of Bcl-xL. Apoptosis. 2006 Oct;11(10):1851-60. doi: 10.1007/s10495-006-9529-6.
• [497] Src Family Kinase Inhibitor PP2 Has Different Effects on All-Trans-Retinoic Acid or Arsenic Trioxide-Induced Differentiation of an Acute Promyelocytic Leukemia Cell Line. Cancer Res Treat. 2013 Jun;45(2):126-33. doi: 10.4143/crt.2013.45.2.126. Epub 2013 Jun 30.
• [498] [Simvastatin-induced apoptosis of K562 cells is mediated by endoplasmic reticulum stress]. Yao Xue Xue Bao. 2008 Apr;43(4):371-7.
• [499] A potential role of calpains in sulfonylureas (SUs) -mediated death of human pancreatic cancer cells (1.2B4). Toxicol In Vitro. 2021 Jun;73:105128. doi: 10.1016/j.tiv.2021.105128. Epub 2021 Feb 27.
• [500] Aspirin Has Antitumor Effects via Expression of Calpain Gene in Cervical Cancer Cells. J Oncol. 2008;2008:285374. doi: 10.1155/2008/285374. Epub 2008 Sep 29.
• [501] Anticancer effects of cantharidin in A431 human skin cancer (Epidermoid carcinoma) cells in vitro and in vivo. Environ Toxicol. 2017 Mar;32(3):723-738. doi: 10.1002/tox.22273. Epub 2016 Apr 25.
• [502] Crystal structure of -hexosaminidase B in complex with pyrimethamine, a potential pharmacological chaperone. J Med Chem. 2011 Mar 10;54(5):1421-9. doi: 10.1021/jm101443u. Epub 2011 Jan 25.
• [503] Antineoplastic effects of gamma linolenic Acid on hepatocellular carcinoma cell lines. J Clin Biochem Nutr. 2010 Jul;47(1):81-90.
• [504] Dextromethorphan - A widely-used cough suppressant - Induces local anaphylaxis via MRGPRX2 on mast cells. Chem Biol Interact. 2020 Oct 1;330:109248. doi: 10.1016/j.cbi.2020.109248. Epub 2020 Aug 29.
• [505] Arsenic trioxide (As(2)O(3)) induced apoptosis and its mechanisms in a human esophageal squamous carcinoma cell line. Chin Med J (Engl). 2002 Feb;115(2):280-5.
• [506] Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction. J Toxicol Sci. 2020;45(11):673-680. doi: 10.2131/jts.45.673.
• [507] Simvastatin induces heat shock factor 1 in vascular endothelial cells. Atherosclerosis. 2006 Oct;188(2):265-73. doi: 10.1016/j.atherosclerosis.2005.10.045. Epub 2005 Dec 20.
• [508] Gene expression changes in human small airway epithelial cells exposed to Delta9-tetrahydrocannabinol. Toxicol Lett. 2005 Aug 14;158(2):95-107.
• [509] Estrogen utilization of IGF-1-R and EGF-R to signal in breast cancer cells. J Steroid Biochem Mol Biol. 2010 Feb 28;118(4-5):219-30. doi: 10.1016/j.jsbmb.2009.09.018. Epub 2009 Oct 6.
• [510] Implication of the insulin-like growth factor-IR pathway in the resistance of non-small cell lung cancer cells to treatment with gefitinib. Clin Cancer Res. 2007 May 1;13(9):2795-803. doi: 10.1158/1078-0432.CCR-06-2077.
• [511] Low-expressional IGF1 mediated methimazole-induced liver developmental toxicity in fetal mice. Toxicology. 2018 Sep 1;408:70-79. doi: 10.1016/j.tox.2018.07.004. Epub 2018 Jul 7.
• [512] Simvastatin inhibits the proliferation of human prostate cancer PC-3 cells via down-regulation of the insulin-like growth factor 1 receptor. Biochem Biophys Res Commun. 2008 Jul 25;372(2):356-61. doi: 10.1016/j.bbrc.2008.05.043. Epub 2008 May 19.
• [513] Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy. Med Oncol. 2011 Dec;28(4):1395-404. doi: 10.1007/s12032-010-9603-3. Epub 2010 Jul 2.
• [514] Arsenic trioxide and cisplatin synergism increase cytotoxicity in human ovarian cancer cells: therapeutic potential for ovarian cancer. Cancer Sci. 2009 Dec;100(12):2459-64.
• [515] Delta9-tetrahydrocannabinol inhibits cytotrophoblast cell proliferation and modulates gene transcription. Mol Hum Reprod. 2006 May;12(5):321-33. doi: 10.1093/molehr/gal036. Epub 2006 Apr 5.
• [516] Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23. doi: 10.1007/s00204-013-1169-3. Epub 2013 Nov 30.
• [517] A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system. Toxicol Sci. 2005 Feb;83(2):282-92.
• [518] Determination of phospholipidosis potential based on gene expression analysis in HepG2 cells. Toxicol Sci. 2007 Mar;96(1):101-14.
• [519] The induction of cytochrome P450 2E1 by ethanol leads to the loss of synaptic proteins via PPARalpha down-regulation. Toxicology. 2017 Jun 15;385:18-27.
• [520] The antiretroviral nucleoside analogue Abacavir reduces cell growth and promotes differentiation of human medulloblastoma cells. Int J Cancer. 2009 Jul 1;125(1):235-43. doi: 10.1002/ijc.24331.
• [521] Patterns of selective neuronal damage in methamphetamine-user AIDS patients. J Acquir Immune Defic Syndr. 2003 Dec 15;34(5):467-74. doi: 10.1097/00126334-200312150-00004.
• [522] Impaired migration of trophoblast cells caused by simvastatin is associated with decreased membrane IGF-I receptor, MMP2 activity and HSP27 expression. Hum Reprod. 2007 Apr;22(4):1161-7. doi: 10.1093/humrep/del464. Epub 2006 Dec 11.
• [523] Quercetin Suppresses the Migration and Invasion in Human Colon Cancer Caco-2 Cells Through Regulating Toll-like Receptor 4/Nuclear Factor-kappa B Pathway. Pharmacogn Mag. 2016 May;12(Suppl 2):S237-44. doi: 10.4103/0973-1296.182154. Epub 2016 May 11.
• [524] Troglitazone but not conjugated linoleic acid reduces gene expression and activity of matrix-metalloproteinases-2 and -9 in PMA-differentiated THP-1 macrophages. J Nutr Biochem. 2008 Sep;19(9):594-603. doi: 10.1016/j.jnutbio.2007.08.003. Epub 2007 Dec 21.
• [525] Multifaceted suppression of aggressive behavior of thyroid carcinoma by all-trans retinoic acid induced re-differentiation. Mol Cell Endocrinol. 2012 Jan 2;348(1):260-9. doi: 10.1016/j.mce.2011.09.002. Epub 2011 Sep 6.
• [526] Repetitive nonlethal oxidant injury to retinal pigment epithelium decreased extracellular matrix turnover in vitro and induced sub-RPE deposits in vivo. Invest Ophthalmol Vis Sci. 2006 Sep;47(9):4098-112. doi: 10.1167/iovs.05-1230.
• [527] Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.
• [528] Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling. Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21737-42. doi: 10.1073/pnas.1007863107. Epub 2010 Nov 22.
• [529] Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
• [530] Patterns of some extracellular matrix gene expression are similar in cells from cleft lip-palate patients and in human palatal fibroblasts exposed to diazepam in culture. Toxicology. 2009 Mar 4;257(1-2):10-6. doi: 10.1016/j.tox.2008.12.002. Epub 2008 Dec 9.
• [531] Imiquimod: a potential weapon against Dupuytren contracture. Med Hypotheses. 2006;66(5):991-2. doi: 10.1016/j.mehy.2005.09.052. Epub 2005 Dec 20.
• [532] Osmotic Induction of Angiogenic Growth Factor Expression in Human Retinal Pigment Epithelial Cells. PLoS One. 2016 Jan 22;11(1):e0147312. doi: 10.1371/journal.pone.0147312. eCollection 2016.
• [533] The role of simvastatin in the osteogenesis of injectable tissue-engineered bone based on human adipose-derived stromal cells and platelet-rich plasma. Biomaterials. 2010 Jul;31(20):5325-35. doi: 10.1016/j.biomaterials.2010.03.037. Epub 2010 Apr 9.
• [534] Proliferation of cultured human gingival fibroblasts caused by isradipine, a dihydropyridine-derivative calcium antagonist. Eur J Med Res. 2004 Jun 30;9(6):313-5.
• [535] The effect of valdecoxib on the production of growth factors evoked by hypoxia and bacterial lipopolysaccharide in HMEC-1 cells. Adv Clin Exp Med. 2013 Nov-Dec;22(6):795-800.
• [536] Retinoic acid can induce markers of endocrine transdifferentiation in pancreatic ductal adenocarcinoma: preliminary observations from an in vitro cell line model. J Clin Pathol. 2006 Jun;59(6):603-10. doi: 10.1136/jcp.2005.032003. Epub 2006 Feb 10.
• [537] Using a customized DNA microarray for expression profiling of the estrogen-responsive genes to evaluate estrogen activity among natural estrogens and industrial chemicals. Environ Health Perspect. 2004 May;112(7):773-81. doi: 10.1289/ehp.6753.
• [538] [Toxic effects of aluminum on human embryonic cerebral neurocytes in vitro studies]. Zhonghua Yu Fang Yi Xue Za Zhi. 2000 Mar;34(2):106-8.
• [539] Biological specificity of CDK4/6 inhibitors: dose response relationship, in vivo signaling, and composite response signature. Oncotarget. 2017 Jul 4;8(27):43678-43691. doi: 10.18632/oncotarget.18435.
• [540] Dexamethasone and the inflammatory response in explants of human omental adipose tissue. Mol Cell Endocrinol. 2010 Feb 5;315(1-2):292-8.
• [541] Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x. Epub 2009 Apr 8.
• [542] Protective role of HO-1 for alcohol-dependent liver damage. Dig Dis. 2010;28(6):792-8. doi: 10.1159/000324287. Epub 2011 Apr 27.
• [543] ERE-independent ERalpha target genes differentially expressed in human breast tumors. Mol Cell Endocrinol. 2005 Dec 21;245(1-2):53-9. doi: 10.1016/j.mce.2005.10.003. Epub 2005 Nov 17.
• [544] Neuroprotective effects of glucomoringin-isothiocyanate against H(2)O(2)-Induced cytotoxicity in neuroblastoma (SH-SY5Y) cells. Neurotoxicology. 2019 Dec;75:89-104. doi: 10.1016/j.neuro.2019.09.008. Epub 2019 Sep 12.
• [545] High selenium status in individuals exposed to arsenic through coal-burning in Shaanxi (PR of China) modulates antioxidant enzymes, heme oxygenase-1 and DNA damage. Clin Chim Acta. 2010 Sep 6;411(17-18):1312-8.
• [546] Dimethyl Fumarate Inhibits the Nuclear Factor B Pathway in Breast Cancer Cells by Covalent Modification of p65 Protein. J Biol Chem. 2016 Feb 12;291(7):3639-47. doi: 10.1074/jbc.M115.679704. Epub 2015 Dec 18.
• [547] Combination treatment with arsenic trioxide and sulindac enhances apoptotic cell death in lung cancer cells via activation of oxidative stress and mitogen-activated protein kinases. Oncol Rep. 2008 Aug;20(2):379-84.
• [548] Evidence of securin-mediated resistance to gefitinib-induced apoptosis in human cancer cells. Chem Biol Interact. 2013 Apr 25;203(2):412-22. doi: 10.1016/j.cbi.2013.03.011. Epub 2013 Mar 22.
• [549] Cigarette smoke and asbestos activate poly-ADP-ribose polymerase in alveolar epithelial cells. J Investig Med. 2001 Jan;49(1):68-76. doi: 10.2310/6650.2001.34092.
• [550] The antidepressants imipramine, clomipramine, and citalopram induce apoptosis in human acute myeloid leukemia HL-60 cells via caspase-3 activation. J Biochem Mol Toxicol. 1999;13(6):338-47. doi: 10.1002/(sici)1099-0461(1999)13:6<338::aid-jbt8>3.0.co;2-7.
• [551] Ciprofloxacin mediated cell growth inhibition, S/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line. Clin Cancer Res. 2000 Mar;6(3):891-900.
• [552] Investigation of molecular mechanisms underlying the antiproliferative effects of colchicine against PC3 prostate cancer cells. Toxicol In Vitro. 2021 Jun;73:105138. doi: 10.1016/j.tiv.2021.105138. Epub 2021 Mar 6.
• [553] Sulindac enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human lung cancer. Mol Cancer Ther. 2005 Feb;4(2):291-304.
• [554] Methotrexate induces poly(ADP-ribose) polymerase-dependent, caspase 3-independent apoptosis in subsets of proliferating CD4+ T cells. Clin Exp Immunol. 2007 May;148(2):288-95. doi: 10.1111/j.1365-2249.2007.03335.x. Epub 2007 Feb 7.
• [555] Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene cluster. Pharmacogenet Genomics. 2006 Apr;16(4):287-96. doi: 10.1097/01.fpc.0000189800.88596.7a.
• [556] Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound. Toxicol In Vitro. 2021 Jun;73:105112. doi: 10.1016/j.tiv.2021.105112. Epub 2021 Feb 22.
• [557] Bone marrow osteoblast damage by chemotherapeutic agents. PLoS One. 2012;7(2):e30758. doi: 10.1371/journal.pone.0030758. Epub 2012 Feb 17.
• [558] Influence of Iron on Cytotoxicity and Gene Expression Profiles Induced by Arsenic in HepG2 Cells. Int J Environ Res Public Health. 2019 Nov 14;16(22):4484. doi: 10.3390/ijerph16224484.
• [559] Profile of estrogen-responsive genes in an estrogen-specific mammary gland outgrowth model. Mol Reprod Dev. 2009 Aug;76(8):733-50. doi: 10.1002/mrd.21041.
• [560] Epigallocatechin-3-gallate (EGCG) protects against chromate-induced toxicity in vitro. Toxicol Appl Pharmacol. 2012 Jan 15;258(2):166-75.
• [561] Moving toward integrating gene expression profiling into high-throughput testing: a gene expression biomarker accurately predicts estrogen receptor alpha modulation in a microarray compendium. Toxicol Sci. 2016 May;151(1):88-103.
• [562] A Gene Expression Biomarker Identifies Chemical Modulators of Estrogen Receptor in an MCF-7 Microarray Compendium. Chem Res Toxicol. 2021 Feb 15;34(2):313-329. doi: 10.1021/acs.chemrestox.0c00243. Epub 2021 Jan 6.
• [563] Changes in gene expression profiles of multiple myeloma cells induced by arsenic trioxide (ATO): possible mechanisms to explain ATO resistance in vivo. Br J Haematol. 2005 Mar;128(5):636-44.
• [564] Changes in gene expressions elicited by physiological concentrations of genistein on human endometrial cancer cells. Mol Carcinog. 2006 Oct;45(10):752-63.
• [565] Factors associated with the therapeutic efficacy of retinoic acids on malignant lymphomas. J Formos Med Assoc. 1997 Jul;96(7):525-34.
• [566] Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program. Chem Res Toxicol. 2010 Mar 15;23(3):578-90. doi: 10.1021/tx900325g.
• [567] Nuclear and Mitochondrial DNA Methylation Patterns Induced by Valproic Acid in Human Hepatocytes. Chem Res Toxicol. 2017 Oct 16;30(10):1847-1854. doi: 10.1021/acs.chemrestox.7b00171. Epub 2017 Sep 13.
• [568] 4.8% sevoflurane induces activation of autophagy in human neuroblastoma SH-SY5Y cells by the AMPK/mTOR signaling pathway. Neurotoxicology. 2022 May;90:256-264. doi: 10.1016/j.neuro.2022.04.008. Epub 2022 Apr 23.
• [569] Enhanced chemotherapeutic efficacy of docetaxel in human lung cancer cell line via GLUT1 inhibitor. J Biochem Mol Toxicol. 2023 Jun;37(6):e23348. doi: 10.1002/jbt.23348. Epub 2023 Mar 31.
• [570] Breast cancer cells response to the antineoplastic agents cisplatin, carboplatin, and doxorubicin at the mRNA expression levels of distinct apoptosis-related genes, including the new member, BCL2L12. Ann N Y Acad Sci. 2007 Jan;1095:35-44. doi: 10.1196/annals.1397.005.
• [571] Extracellular signal-regulated kinase activation and Bcl-2 downregulation mediate apoptosis after gemcitabine treatment partly via a p53-independent pathway. Eur J Pharmacol. 2004 Oct 19;502(3):169-83. doi: 10.1016/j.ejphar.2004.09.006.
• [572] Verapamil potentiates anti-glioblastoma efficacy of temozolomide by modulating apoptotic signaling. Toxicol In Vitro. 2018 Oct;52:306-313. doi: 10.1016/j.tiv.2018.07.001. Epub 2018 Jul 9.
• [573] Inhibition of caspase-dependent mitochondrial permeability transition protects airway epithelial cells against mustard-induced apoptosis. Apoptosis. 2006 Sep;11(9):1545-59. doi: 10.1007/s10495-006-8764-1.
• [574] -Carotene Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cell Lines via the Cav-1/AKT/NF-B Signaling Pathway. J Biochem Mol Toxicol. 2016 Mar;30(3):148-57. doi: 10.1002/jbt.21773. Epub 2016 Jan 6.
• [575] Gene expression profiling of early primary biliary cirrhosis: possible insights into the mechanism of action of ursodeoxycholic acid. Liver Int. 2008 Aug;28(7):997-1010. doi: 10.1111/j.1478-3231.2008.01744.x. Epub 2008 Apr 15.
• [576] Differential responses to retinoic acid and endocrine disruptor compounds of subpopulations within human embryonic stem cell lines. Differentiation. 2012 Nov;84(4):330-43. doi: 10.1016/j.diff.2012.07.006. Epub 2012 Aug 18.
• [577] Dexamethasone controls aryl hydrocarbon receptor (AhR)-mediated CYP1A1 and CYP1A2 expression and activity in primary cultures of human hepatocytes. Chem Biol Interact. 2009 May 15;179(2-3):288-96.
• [578] The effect of mitotane on viability, steroidogenesis and gene expression in NCI295R adrenocortical cells. Mol Med Rep. 2013 Mar;7(3):893-900.
• [579] The G Protein-Coupled Estrogen Receptor Agonist G-1 Inhibits Nuclear Estrogen Receptor Activity and Stimulates Novel Phosphoproteomic Signatures. Toxicol Sci. 2016 Jun;151(2):434-46. doi: 10.1093/toxsci/kfw057. Epub 2016 Mar 29.
• [580] Expression Profiling of Human Pluripotent Stem Cell-Derived Cardiomyocytes Exposed to Doxorubicin-Integration and Visualization of Multi-Omics Data. Toxicol Sci. 2018 May 1;163(1):182-195. doi: 10.1093/toxsci/kfy012.
• [581] Sorafenib induces growth suppression in mouse models of gastrointestinal stromal tumor. Mol Cancer Ther. 2009 Jan;8(1):152-9. doi: 10.1158/1535-7163.MCT-08-0553.
• [582] [Demethylation effect of inhibitor As2O3 on expression of SHP-1 and C-kit genes in leukemia HL-60 cells]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2013 Jun;21(3):613-6. doi: 10.7534/j.issn.1009-2137.2013.03.015.
• [583] Cardiac toxicity from ethanol exposure in human-induced pluripotent stem cell-derived cardiomyocytes. Toxicol Sci. 2019 May 1;169(1):280-292.
• [584] Targeting iron homeostasis induces cellular differentiation and synergizes with differentiating agents in acute myeloid leukemia. J Exp Med. 2010 Apr 12;207(4):731-50. doi: 10.1084/jem.20091488. Epub 2010 Apr 5.
• [585] Lon protease and eiF2 are involved in acute, but not prolonged, antiretroviral induced stress response in HepG2 cells. Chem Biol Interact. 2016 May 25;252:82-6. doi: 10.1016/j.cbi.2016.03.021. Epub 2016 Apr 1.
• [586] Darinaparsin induces a unique cellular response and is active in an arsenic trioxide-resistant myeloma cell line. Mol Cancer Ther. 2009 May;8(5):1197-206.
• [587] Establishment of a 13 genes-based molecular prediction score model to discriminate the neurotoxic potential of food relevant-chemicals. Toxicol Lett. 2022 Feb 1;355:1-18. doi: 10.1016/j.toxlet.2021.10.013. Epub 2021 Nov 5.
• [588] Pharmacogenomic analysis of acute promyelocytic leukemia cells highlights CYP26 cytochrome metabolism in differential all-trans retinoic acid sensitivity. Blood. 2007 May 15;109(10):4450-60.
• [589] Proteomic and functional analyses reveal a dual molecular mechanism underlying arsenic-induced apoptosis in human multiple myeloma cells. J Proteome Res. 2009 Jun;8(6):3006-19.
• [590] Indomethacin and ibuprofen induce Hsc70 nuclear localization and activation of the heat shock response in HeLa cells. Biochem Biophys Res Commun. 2004 Jan 23;313(4):863-70. doi: 10.1016/j.bbrc.2003.12.018.
• [591] Insulin regulation of hexose transport in mouse 3T3-L1 cells expressing the human HepG2 glucose transporter. J Biol Chem. 1990 Nov 25;265(33):20106-16.
• [592] Effects of troglitazone on cellular differentiation, insulin signaling, and glucose metabolism in cultured human skeletal muscle cells. Biochem Biophys Res Commun. 2001 Jan 26;280(3):664-74. doi: 10.1006/bbrc.2000.4216.
• [593] Disturbance of cellular glucose transport by two prevalently used fluoroquinolone antibiotics ciprofloxacin and levofloxacin involves glucose transporter type 1. Toxicol Lett. 2009 Jan 30;184(2):81-4. doi: 10.1016/j.toxlet.2008.10.017. Epub 2008 Oct 28.
• [594] Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity. Arch Toxicol. 2018 Jan;92(1):469-485.
• [595] Arsenic trioxide induces autophagic cell death in osteosarcoma cells via the ROS-TFEB signaling pathway. Biochem Biophys Res Commun. 2018 Jan 29;496(1):167-175. doi: 10.1016/j.bbrc.2018.01.018. Epub 2018 Jan 4.
• [596] Imatinib disturbs lysosomal function and morphology and impairs the activity of mTORC1 in human hepatocyte cell lines. Food Chem Toxicol. 2022 Apr;162:112869. doi: 10.1016/j.fct.2022.112869. Epub 2022 Feb 16.
• [597] Induction of Sestrin2 by pterostilbene suppresses ethanol-triggered hepatocyte senescence by degrading CCN1 via p62-dependent selective autophagy. Cell Biol Toxicol. 2023 Jun;39(3):729-749. doi: 10.1007/s10565-021-09635-8. Epub 2021 Aug 17.
• [598] Rosiglitazone induces autophagy in H295R and cell cycle deregulation in SW13 adrenocortical cancer cells. Exp Cell Res. 2011 Jun 10;317(10):1397-410. doi: 10.1016/j.yexcr.2011.02.014. Epub 2011 Mar 3.
• [599] Incidence of mutation and deletion in topoisomerase II alpha mRNA of etoposide and mAMSA-resistant cell lines. Jpn J Cancer Res. 2001 Oct;92(10):1133-7. doi: 10.1111/j.1349-7006.2001.tb01069.x.
• [600] HU-331 and Oxidized Cannabidiol Act as Inhibitors of Human Topoisomerase II and . Chem Res Toxicol. 2018 Feb 19;31(2):137-144. doi: 10.1021/acs.chemrestox.7b00302. Epub 2018 Jan 8.
• [601] Interactions between the etoposide derivative F14512 and human type II topoisomerases: implications for the C4 spermine moiety in promoting enzyme-mediated DNA cleavage. Biochemistry. 2011 Apr 19;50(15):3240-9. doi: 10.1021/bi200094z. Epub 2011 Mar 28.
• [602] The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib. Toxicol Sci. 2023 Dec 21;197(1):69-78. doi: 10.1093/toxsci/kfad099.
• [603] Arsenic trioxide exposure to ovarian carcinoma cells leads to decreased level of topoisomerase II and cytotoxicity. Int J Gynecol Cancer. 2006 Jul-Aug;16(4):1552-6. doi: 10.1111/j.1525-1438.2006.00626.x.
• [604] Isoniazid-induced apoptosis in HepG2 cells: generation of oxidative stress and Bcl-2 down-regulation. Toxicol Mech Methods. 2010 Jun;20(5):242-51. doi: 10.3109/15376511003793325.
• [605] p16-Cdk4-Rb axis controls sensitivity to a cyclin-dependent kinase inhibitor PD0332991 in glioblastoma xenograft cells. Neuro Oncol. 2012 Jul;14(7):870-81. doi: 10.1093/neuonc/nos114. Epub 2012 Jun 18.
• [606] In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells. Food Chem Toxicol. 2022 Jan;159:112722. doi: 10.1016/j.fct.2021.112722. Epub 2021 Dec 3.
• [607] JNK1 is required for sulindac-mediated inhibition of cell proliferation and induction of apoptosis in vitro and in vivo. Eur J Pharmacol. 2007 Apr 10;560(2-3):95-100. doi: 10.1016/j.ejphar.2007.01.020. Epub 2007 Jan 19.
• [608] Simvastatin inhibits cell growth and induces apoptosis and G0/G1 cell cycle arrest in hepatic cancer cells. Int J Mol Med. 2010 Nov;26(5):735-41. doi: 10.3892/ijmm_00000520.
• [609] A gene signature-based approach identifies thioridazine as an inhibitor of phosphatidylinositol-3'-kinase (PI3K)/AKT pathway in ovarian cancer cells. Gynecol Oncol. 2011 Jan;120(1):121-7. doi: 10.1016/j.ygyno.2010.10.003. Epub 2010 Oct 29.
• [610] Effects of formaldehyde, acetaldehyde, benzoyl peroxide, and hydrogen peroxide on cultured normal human bronchial epithelial cells. Cancer Res. 1985 Jun;45(6):2522-6.
• [611] Methotrexate induced differentiation in colon cancer cells is primarily due to purine deprivation. J Cell Biochem. 2006 Sep 1;99(1):146-55. doi: 10.1002/jcb.20908.
• [612] Quercetin inhibits the expression and function of the androgen receptor in LNCaP prostate cancer cells. Carcinogenesis. 2001 Mar;22(3):409-14. doi: 10.1093/carcin/22.3.409.
• [613] DNA array analysis of the effects of aspirin on colon cancer cells: involvement of Rac1. Carcinogenesis. 2004 Jul;25(7):1293-8.
• [614] Adrenergic modulation of cardiac development in the rat: effects of prenatal exposure to propranolol via continuous maternal infusion. J Dev Physiol. 1990 May;13(5):243-9.
• [615] Tryptanthrin induces growth inhibition and neuronal differentiation in the human neuroblastoma LA-N-1 cells. Chem Biol Interact. 2013 Apr 25;203(2):512-21. doi: 10.1016/j.cbi.2013.03.001. Epub 2013 Mar 13.
• [616] Protective role of Ashwagandha leaf extract and its component withanone on scopolamine-induced changes in the brain and brain-derived cells. PLoS One. 2011;6(11):e27265. doi: 10.1371/journal.pone.0027265. Epub 2011 Nov 11.
• [617] Epigenetic silencing of novel tumor suppressors in malignant melanoma. Cancer Res. 2006 Dec 1;66(23):11187-93. doi: 10.1158/0008-5472.CAN-06-1274.
• [618] Arsenic metabolites affect expression of the neurofilament and tau genes: an in-vitro study into the mechanism of arsenic neurotoxicity. Toxicol In Vitro. 2007 Sep;21(6):1104-12. doi: 10.1016/j.tiv.2007.04.007. Epub 2007 Apr 27.
• [619] Folic acid induces cell type-specific changes in the transcriptome of breast cancer cell lines: a proof-of-concept study. J Nutr Sci. 2016 Apr 26;5:e17. doi: 10.1017/jns.2016.8. eCollection 2016.
• [620] Mitochondrial proteomics investigation of a cellular model of impaired dopamine homeostasis, an early step in Parkinson's disease pathogenesis. Mol Biosyst. 2014 Jun;10(6):1332-44.
• [621] Evaluation of developmental toxicity using undifferentiated human embryonic stem cells. J Appl Toxicol. 2015 Feb;35(2):205-18.
• [622] Cytosine arabinoside induces ectoderm and inhibits mesoderm expression in human embryonic stem cells during multilineage differentiation. Br J Pharmacol. 2011 Apr;162(8):1743-56.
• [623] Nitric oxide causes anoikis through attenuation of E-cadherin and activation of caspase-3 in human gastric carcinoma AZ-521 cells infected with Mycoplasma hyorhinis. J Vet Med Sci. 2010 Jul;72(7):869-74.
• [624] Induced differentiation in HT29, a human colon adenocarcinoma cell line. J Cell Sci. 1999 Aug;112 ( Pt 16):2657-66. doi: 10.1242/jcs.112.16.2657.
• [625] Antitumoral activity of liraglutide, a new DNMT inhibitor in breast cancer cells in vitro and in vivo. Chem Biol Interact. 2021 Nov 1;349:109641. doi: 10.1016/j.cbi.2021.109641. Epub 2021 Sep 14.
• [626] Troglitazone increases expression of E-cadherin and claudin 4 in human pancreatic cancer cells. Biochem Biophys Res Commun. 2009 Mar 13;380(3):614-9. doi: 10.1016/j.bbrc.2009.01.134. Epub 2009 Jan 27.
• [627] Regulation of epithelial cell morphology and functions approaching to more in vivo-like by modifying polyethylene glycol on polysulfone membranes. PLoS One. 2012;7(4):e36110.
• [628] SKI-606 decreases growth and motility of colorectal cancer cells by preventing pp60(c-Src)-dependent tyrosine phosphorylation of beta-catenin and its nuclear signaling. Cancer Res. 2006 Feb 15;66(4):2279-86. doi: 10.1158/0008-5472.CAN-05-2057.
• [629] Selective activation of Src family kinases and JNK by low levels of chromium(VI). Toxicol Appl Pharmacol. 2003 Aug 1;190(3):214-23. doi: 10.1016/s0041-008x(03)00188-1.
• [630] Quercetin exerts anti-melanoma activities and inhibits STAT3 signaling. Biochem Pharmacol. 2014 Feb 1;87(3):424-34. doi: 10.1016/j.bcp.2013.11.008. Epub 2013 Nov 23.
• [631] Dehydroepiandrosterone Activation of G-protein-coupled Estrogen Receptor Rapidly Stimulates MicroRNA-21 Transcription in Human Hepatocellular Carcinoma Cells. J Biol Chem. 2015 Jun 19;290(25):15799-15811. doi: 10.1074/jbc.M115.641167. Epub 2015 May 11.
• [632] Mithramycin inhibits human epithelial carcinoma cell proliferation and migration involving downregulation of Eps8 expression. Chem Biol Interact. 2010 Jan 5;183(1):181-6. doi: 10.1016/j.cbi.2009.09.018.
• [633] High-throughput cell-based screening of 4910 known drugs and drug-like small molecules identifies disulfiram as an inhibitor of prostate cancer cell growth. Clin Cancer Res. 2009 Oct 1;15(19):6070-8.
• [634] Dose-finding study of paliperidone ER based on striatal and extrastriatal dopamine D2 receptor occupancy in patients with schizophrenia. Psychopharmacology (Berl). 2008 Apr;197(2):229-35. doi: 10.1007/s00213-007-1029-z. Epub 2007 Dec 6.
• [635] Positron emission tomography measurement of dopamine D? receptor occupancy in the pituitary and cerebral cortex: relation to antipsychotic-induced hyperprolactinemia. J Clin Psychiatry. 2010 Sep;71(9):1131-7. doi: 10.4088/JCP.08m04307yel. Epub 2010 Feb 23.
• [636] Variants of the dopamine D2 receptor gene and risperidone-induced hyperprolactinemia in children and adolescents. Pharmacogenet Genomics. 2009 May;19(5):373-82. doi: 10.1097/FPC.0b013e328329a60f.
• [637] Dopamine receptor D2 gene is associated with weight gain in schizophrenic patients under long-term atypical antipsychotic treatment. Pharmacogenet Genomics. 2010 Jun;20(6):359-66. doi: 10.1097/FPC.0b013e3283397d06.
• [638] A preliminary study: novelty seeking, frontal executive function, and dopamine receptor (D2) TaqI A gene polymorphism in patients with methamphetamine dependence. Compr Psychiatry. 2008 Jul-Aug;49(4):387-92. doi: 10.1016/j.comppsych.2008.01.008. Epub 2008 Mar 21.
• [639] Imaging gene-substance interactions: the effect of the DRD2 TaqIA polymorphism and the dopamine agonist bromocriptine on the brain activation during the anticipation of reward. Neurosci Lett. 2006 Sep 25;405(3):196-201. doi: 10.1016/j.neulet.2006.07.030. Epub 2006 Aug 8.
• [640] Discovery of antiandrogen activity of nonsteroidal scaffolds of marketed drugs. Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):11927-32. doi: 10.1073/pnas.0609752104. Epub 2007 Jul 2.
• [641] Synthesis and antitumor evaluation of nitrovinyl biphenyls: anticancer agents based on allocolchicines. ChemMedChem. 2011 May 2;6(5):859-68. doi: 10.1002/cmdc.201100019. Epub 2011 Apr 6.
• [642] Cannabidiol Effectively Promoted Cell Death in Bladder Cancer and the Improved Intravesical Adhesion Drugs Delivery Strategy Could Be Better Used for Treatment. Pharmaceutics. 2021 Sep 7;13(9):1415. doi: 10.3390/pharmaceutics13091415.
• [643] Frankincense myrrh attenuates hepatocellular carcinoma by regulating tumor blood vessel development through multiple epidermal growth factor receptor-mediated signaling pathways. World J Gastrointest Oncol. 2022 Feb 15;14(2):450-477. doi: 10.4251/wjgo.v14.i2.450.
• [644] Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts. Biomed Res Int. 2015;2015:257090. doi: 10.1155/2015/257090. Epub 2015 Aug 3.
• [645] Pentosan polysulfate decreases proliferation and extracellular matrix deposition by vascular smooth muscle cells isolated from failed hemodialysis access grafts. Clin Nephrol. 2000 Aug;54(2):121-7.
• [646] Matrix metalloproteinase-9 is involved in chronic lymphocytic leukemia cell response to fludarabine and arsenic trioxide. PLoS One. 2014 Jun 23;9(6):e99993. doi: 10.1371/journal.pone.0099993. eCollection 2014.
• [647] Simvastatin, an HMG-CoA reductase inhibitor, reduced the expression of matrix metalloproteinase-9 (Gelatinase B) in osteoblastic cells and HT1080 fibrosarcoma cells. J Pharmacol Sci. 2004 Apr;94(4):403-9. doi: 10.1254/jphs.94.403.
• [648] Resveratrol inhibits hydrogen peroxide-induced apoptosis in endothelial cells via the activation of PI3K/Akt by miR-126. J Atheroscler Thromb. 2014;21(2):108-18. doi: 10.5551/jat.19257. Epub 2013 Oct 10.
• [649] Posttranslational glutathiolation of aldose reductase (AKR1B1): a possible mechanism of protein recovery from S-nitrosylation. Chem Biol Interact. 2009 Mar 16;178(1-3):250-8. doi: 10.1016/j.cbi.2008.11.007. Epub 2008 Nov 18.
• [650] Phase IIa trial of fingolimod for amyotrophic lateral sclerosis demonstrates acceptable acute safety and tolerability. Muscle Nerve. 2017 Dec;56(6):1077-1084. doi: 10.1002/mus.25733. Epub 2017 Aug 29.
• [651] Epicatechin and a cocoa polyphenolic extract modulate gene expression in human Caco-2 cells. J Nutr. 2004 Oct;134(10):2509-16.
• [652] Unique signatures of stress-induced senescent human astrocytes. Exp Neurol. 2020 Dec;334:113466. doi: 10.1016/j.expneurol.2020.113466. Epub 2020 Sep 17.
• [653] A comprehensive analysis of Wnt/beta-catenin signaling pathway-related genes and crosstalk pathways in the treatment of As2O3 in renal cancer. Ren Fail. 2018 Nov;40(1):331-339.
• [654] Antitumor effect of aspirin in glioblastoma cells by modulation of -catenin/T-cell factor-mediated transcriptional activity. J Neurosurg. 2011 Oct;115(4):780-8. doi: 10.3171/2011.5.JNS113. Epub 2011 Jul 1.
• [655] Functional cardiotoxicity assessment of cosmetic compounds using human-induced pluripotent stem cell-derived cardiomyocytes. Arch Toxicol. 2018 Jan;92(1):371-381.
• [656] Gypenosides protect retinal pigment epithelium cells from oxidative stress. Food Chem Toxicol. 2018 Feb;112:76-85.
• [657] Enhanced cytotoxicity of bioreductive antitumor agents with dimethyl fumarate in human glioblastoma cells. Anticancer Drugs. 2005 Feb;16(2):167-74.
• [658] Simvastatin protects dopaminergic neurons against MPP+-induced oxidative stress and regulates the endogenous anti-oxidant system through ERK. Cell Physiol Biochem. 2018;51(4):1957-1968.
• [659] P450 3A-catalyzed O-dealkylation of lapatinib induces mitochondrial stress and activates Nrf2. Chem Res Toxicol. 2016 May 16;29(5):784-96.
• [660] Induction of human NAD(P)H:quinone oxidoreductase (NQO1) gene expression by the flavonol quercetin. Toxicol Lett. 2001 Feb 3;119(1):49-57.
• [661] Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
• [662] Comparative proteomics reveals concordant and discordant biochemical effects of caffeine versus epigallocatechin-3-gallate in human endothelial cells. Toxicol Appl Pharmacol. 2019 Sep 1;378:114621. doi: 10.1016/j.taap.2019.114621. Epub 2019 Jun 10.
• [663] Morphological and molecular course of mitochondrial pathology in cultured human cells exposed long-term to Zidovudine. Environ Mol Mutagen. 2007 Apr-May;48(3-4):179-89. doi: 10.1002/em.20245.
• [664] Quercetin, a potent inhibitor against beta-catenin/Tcf signaling in SW480 colon cancer cells. Biochem Biophys Res Commun. 2005 Mar 4;328(1):227-34. doi: 10.1016/j.bbrc.2004.12.151.
• [665] Effects of retinoids on cancerous phenotype and apoptosis in organotypic cultures of ovarian carcinoma. J Natl Cancer Inst. 2001 Apr 4;93(7):516-25. doi: 10.1093/jnci/93.7.516.
• [666] Comparison of base-line and chemical-induced transcriptomic responses in HepaRG and RPTEC/TERT1 cells using TempO-Seq. Arch Toxicol. 2018 Aug;92(8):2517-2531.
• [667] Folate deficiency in normal human fibroblasts leads to altered expression of genes primarily linked to cell signaling, the cytoskeleton and extracellular matrix. J Nutr Biochem. 2007 Aug;18(8):541-52. doi: 10.1016/j.jnutbio.2006.11.002. Epub 2007 Feb 22.
• [668] Peroxisome proliferator activated receptor gamma (PPAR-gama) ligand pioglitazone regulated gene networks in term human primary trophoblast cells. Reprod Toxicol. 2018 Oct;81:99-107.
• [669] Muc-1 core protein is expressed on multiple myeloma cells and is induced by dexamethasone. Blood. 1999 Feb 15;93(4):1287-98.
• [670] Promotion of the articular cartilage proteoglycan degradation by T-2 toxin and selenium protective effect. J Zhejiang Univ Sci B. 2008 Jan;9(1):22-33. doi: 10.1631/jzus.B071322.
• [671] Simvastatin prevents skeletal metastasis of breast cancer by an antagonistic interplay between p53 and CD44. J Biol Chem. 2011 Apr 1;286(13):11314-27. doi: 10.1074/jbc.M110.193714. Epub 2011 Jan 3.
• [672] Enhancement of the antiproliferative activity of gemcitabine by modulation of c-Met pathway in pancreatic cancer. Curr Pharm Des. 2013;19(5):940-50.
• [673] The antipsychotic chlorpromazine suppresses YAP signaling, stemness properties, and drug resistance in breast cancer cells. Chem Biol Interact. 2019 Apr 1;302:28-35. doi: 10.1016/j.cbi.2019.01.033. Epub 2019 Jan 28.
• [674] Carbonyl reductase 1 offers a novel therapeutic target to enhance leukemia treatment by arsenic trioxide. Cancer Res. 2012 Aug 15;72(16):4214-24.
• [675] Proteomic analysis of hepatic effects of phenobarbital in mice with humanized liver. Arch Toxicol. 2022 Oct;96(10):2739-2754. doi: 10.1007/s00204-022-03338-7. Epub 2022 Jul 26.
• [676] In vitro and in vivo irinotecan-induced changes in expression profiles of cell cycle and apoptosis-associated genes in acute myeloid leukemia cells. Mol Cancer Ther. 2005 Jun;4(6):885-900.
• [677] Epigenetic influences of low-dose bisphenol A in primary human breast epithelial cells. Toxicol Appl Pharmacol. 2010 Oct 15;248(2):111-21.
• [678] Tumor necrosis factor-alpha-induced protein 3 as a putative regulator of nuclear factor-kappaB-mediated resistance to O6-alkylating agents in human glioblastomas. J Clin Oncol. 2006 Jan 10;24(2):274-87. doi: 10.1200/JCO.2005.02.9405. Epub 2005 Dec 19.
• [679] Ouabain induces apoptotic cell death in human prostate DU 145 cancer cells through DNA damage and TRAIL pathways. Environ Toxicol. 2019 Dec;34(12):1329-1339. doi: 10.1002/tox.22834. Epub 2019 Aug 21.
• [680] Disulfiram is a direct and potent inhibitor of human O6-methylguanine-DNA methyltransferase (MGMT) in brain tumor cells and mouse brain and markedly increases the alkylating DNA damage. Carcinogenesis. 2014 Mar;35(3):692-702. doi: 10.1093/carcin/bgt366. Epub 2013 Nov 5.
• [681] Induction of the DNA repair gene O6-methylguanine-DNA methyltransferase by dexamethasone in glioblastomas. J Neurosurg. 2004 Oct;101(4):659-63. doi: 10.3171/jns.2004.101.4.0659.
• [682] Phenytoin may increase the efficacy of temozolomide by methylating DNA-repair enzyme, O6-methylguanine-DNA methyltransferase in patients with glioblastoma. Med Hypotheses. 2005;65(4):819-20. doi: 10.1016/j.mehy.2005.04.007.
• [683] Pharmacokinetic, biochemical and clinical effects of dimethyltriazenoimidazole-4-carboxamide-bischloroethylnitrosourea combination therapy in patients with advanced breast cancer. Int J Cancer. 2003 Feb 20;103(5):686-92. doi: 10.1002/ijc.10849.
• [684] Transcriptional repression of O6-methylguanine DNA methyltransferase gene rendering cells hypersensitive to N,N'-bis(2-chloroethyl)-N-nitrosurea in camptothecin-resistant cells. Mol Pharmacol. 2008 Aug;74(2):517-26. doi: 10.1124/mol.107.043620. Epub 2008 May 20.
• [685] Arsenic trioxide induces Hsp70 expression via reactive oxygen species and JNK pathway in MDA231 cells. Life Sci. 2005 Oct 14;77(22):2783-93. doi: 10.1016/j.lfs.2005.04.024.
• [686] A Study of Gentianae Radix et Rhizoma Class Differences Based on Chemical Composition and Core Efficacy. Molecules. 2023 Oct 17;28(20):7132. doi: 10.3390/molecules28207132.
• [687] NOTCH signaling is activated in and contributes to resistance in enzalutamide-resistant prostate cancer cells. J Biol Chem. 2019 May 24;294(21):8543-8554. doi: 10.1074/jbc.RA118.006983. Epub 2019 Apr 2.
• [688] Endoplasmic reticulum stress-mediated apoptosis in imatinib-resistant leukemic K562-r cells triggered by AMN107 combined with arsenic trioxide. Exp Biol Med (Maywood). 2013 Aug 1;238(8):932-42. doi: 10.1177/1535370213492689. Epub 2013 Jul 24.
• [689] DNA microarray analysis of vitamin D-induced gene expression in a human colon carcinoma cell line. Physiol Genomics. 2004 Apr 13;17(2):122-9. doi: 10.1152/physiolgenomics.00002.2003.
• [690] Gamma-irradiation and doxorubicin treatment of normal human cells cause cell cycle arrest via different pathways. Mol Cells. 2005 Dec 31;20(3):331-8.
• [691] Induction of class II major histocompatibility complex expression in human multiple myeloma cells by retinoid. Haematologica. 2007 Jan;92(1):115-20.
• [692] Ursodeoxycholic acid suppresses Cox-2 expression in colon cancer: roles of Ras, p38, and CCAAT/enhancer-binding protein. Nutr Cancer. 2008;60(3):389-400.
• [693] Quercetin represses apolipoprotein B expression by inhibiting the transcriptional activity of C/EBP. PLoS One. 2015 Apr 15;10(4):e0121784. doi: 10.1371/journal.pone.0121784. eCollection 2015.
• [694] Arsenic trioxide inhibits neuroblastoma growth in vivo and promotes apoptotic cell death in vitro. Biochem Biophys Res Commun. 2000 Oct 14;277(1):179-85. doi: 10.1006/bbrc.2000.3651.
• [695] Lovastatin induces neuronal differentiation and apoptosis of embryonal carcinoma and neuroblastoma cells: enhanced differentiation and apoptosis in combination with dbcAMP. Mol Cell Biochem. 2010 Dec;345(1-2):1-11. doi: 10.1007/s11010-010-0553-z. Epub 2010 Aug 9.
• [696] Cholinergic drugs potentiate human nicotinic alpha4beta2 acetylcholine receptors by a competitive mechanism. Eur J Pharmacol. 2005 Feb 21;509(2-3):97-108. doi: 10.1016/j.ejphar.2004.12.037.
• [697] Repetitive nicotine exposure leads to a more malignant and metastasis-prone phenotype of SCLC: a molecular insight into the importance of quitting smoking during treatment. Toxicol Sci. 2010 Aug;116(2):467-76. doi: 10.1093/toxsci/kfq138. Epub 2010 May 10.
• [698] Molecular modelling of the interactions of carbamazepine and a nicotinic receptor involved in the autosomal dominant nocturnal frontal lobe epilepsy. Br J Pharmacol. 2002 Jul;136(6):883-95. doi: 10.1038/sj.bjp.0704786.
• [699] ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A potent and selective cholinergic channel modulator with neuroprotective properties. J Pharmacol Exp Ther. 1997 Oct;283(1):235-46.
• [700] Expression profiling of nucleotide metabolism-related genes in human breast cancer cells after treatment with 5-fluorouracil. Cancer Invest. 2009 Jun;27(5):561-7.
• [701] Convergent transcriptional profiles induced by endogenous estrogen and distinct xenoestrogens in breast cancer cells. Carcinogenesis. 2006 Aug;27(8):1567-78.
• [702] Targeting PFKL with penfluridol inhibits glycolysis and suppresses esophageal cancer tumorigenesis in an AMPK/FOXO3a/BIM-dependent manner. Acta Pharm Sin B. 2022 Mar;12(3):1271-1287. doi: 10.1016/j.apsb.2021.09.007. Epub 2021 Sep 11.
• [703] DHT and testosterone, but not DHEA or E2, differentially modulate IGF-I, IGFBP-2, and IGFBP-3 in human prostatic stromal cells. Am J Physiol Endocrinol Metab. 2006 May;290(5):E952-60. doi: 10.1152/ajpendo.00451.2005. Epub 2005 Dec 20.
• [704] Over-expression, purification, and characterization of recombinant human arylamine N-acetyltransferase 1. Protein J. 2005 Feb;24(2):65-77.
• [705] The xenobiotic-metabolizing enzymes arylamine N-acetyltransferases in human lens epithelial cells: inactivation by cellular oxidants and UVB-induced oxidative stress. Mol Pharmacol. 2005 Apr;67(4):1299-306.
• [706] Sulindac inhibited gene expression and activity of arylamine N-acetyltransferase and DNA-2-aminofluorene adduct formation in T24 human bladder tumor cells. Urol Res. 2001 Dec;29(6):406-11.
• [707] Gene expression profile changes in NB4 cells induced by arsenic trioxide. Acta Pharmacol Sin. 2003 Jul;24(7):646-50.
• [708] Combination of arsenic trioxide and Dasatinib: a new strategy to treat Philadelphia chromosome-positive acute lymphoblastic leukaemia. J Cell Mol Med. 2018 Mar;22(3):1614-1626.
• [709] Arsenic trioxide inhibits EMT in hepatocellular carcinoma by promoting lncRNA MEG3 via PKM2. Biochem Biophys Res Commun. 2019 Jun 11;513(4):834-840. doi: 10.1016/j.bbrc.2019.04.081. Epub 2019 Apr 16.
• [710] Thalidomide suppresses angiogenesis and immune evasion via lncRNA FGD5-AS1/miR-454-3p/ZEB1 axis-mediated VEGFA expression and PD-1/PD-L1 checkpoint in NSCLC. Chem Biol Interact. 2021 Nov 1;349:109652. doi: 10.1016/j.cbi.2021.109652. Epub 2021 Sep 11.
• [711] ?9-tetrahydrocannabinol inhibits epithelial-mesenchymal transition and metastasis by targeting matrix metalloproteinase-9 in endometrial cancer. Oncol Lett. 2018 Jun;15(6):8527-8535. doi: 10.3892/ol.2018.8407. Epub 2018 Apr 2.
• [712] Anti-androgen 2-hydroxyflutamide modulates cadherin, catenin and androgen receptor phosphorylation in androgen-sensitive LNCaP and androgen-independent PC3 prostate cancer cell lines acting via PI3K/Akt and MAPK/ERK1/2 pathways. Toxicol In Vitro. 2017 Apr;40:324-335. doi: 10.1016/j.tiv.2017.01.019. Epub 2017 Feb 2.
• [713] Gene expression profile induced by BCNU in human glioma cell lines with differential MGMT expression. J Neurooncol. 2005 Jul;73(3):189-98.
• [714] Comparison of quantitation methods in proteomics to define relevant toxicological information on AhR activation of HepG2 cells by BaP. Toxicology. 2021 Jan 30;448:152652. doi: 10.1016/j.tox.2020.152652. Epub 2020 Dec 2.
• [715] Environmental pollutant induced cellular injury is reflected in exosomes from placental explants. Placenta. 2020 Jan 1;89:42-49. doi: 10.1016/j.placenta.2019.10.008. Epub 2019 Oct 17.
• [716] 1,25-Dihydroxyvitamin D3 suppresses gene expression of eukaryotic translation initiation factor 2 in human promyelocytic leukemia HL-60 cells. Cell Struct Funct. 2005;30(1):1-6. doi: 10.1247/csf.30.1.
• [717] Antiproliferative effect of ascorbic acid is associated with the inhibition of genes necessary to cell cycle progression. PLoS One. 2009;4(2):e4409.
• [718] Proteomic analysis revealed association of aberrant ROS signaling with suberoylanilide hydroxamic acid-induced autophagy in Jurkat T-leukemia cells. Autophagy. 2010 Aug;6(6):711-24. doi: 10.4161/auto.6.6.12397. Epub 2010 Aug 17.
• [719] CDK4/6 inhibition provides a potent adjunct to Her2-targeted therapies in preclinical breast cancer models. Genes Cancer. 2014 Jul;5(7-8):261-72. doi: 10.18632/genesandcancer.24.
• [720] Focal striatal dopamine may potentiate dyskinesias in parkinsonian monkeys. Exp Neurol. 2006 Feb;197(2):363-72. doi: 10.1016/j.expneurol.2005.10.022. Epub 2005 Dec 9.
• [721] Decarboxylases as hypothetical targets for actions of organophosphates: Molecular modeling for prediction of hidden and unexpected health threats. Food Chem Toxicol. 2022 Mar;161:112856. doi: 10.1016/j.fct.2022.112856. Epub 2022 Feb 11.
• [722] A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo. Carcinogenesis. 2012 Jul;33(7):1421-9.
• [723] Nephrotoxicity induced by cisplatin is primarily due to the activation of the 5-hydroxytryptamine degradation system in proximal renal tubules. Chem Biol Interact. 2021 Nov 1;349:109662. doi: 10.1016/j.cbi.2021.109662. Epub 2021 Sep 21.
• [724] The relative role of CYP3A4 and CYP3A5 in eplerenone metabolism. Toxicol Lett. 2019 Oct 15;315:9-13.
• [725] Characterization of the structural determinants required for potent mechanism-based inhibition of human cytochrome P450 1A1 by cannabidiol. Chem Biol Interact. 2014 May 25;215:62-8.
• [726] Mechanism-based inactivation of CYP3A by HIV protease inhibitors. J Pharmacol Exp Ther. 2005 Feb;312(2):583-91.
• [727] Contribution of CYP3A5 to hepatic and renal ifosfamide N-dechloroethylation. Drug Metab Dispos. 2005 Jul;33(7):1074-81. doi: 10.1124/dmd.104.002279. Epub 2005 Apr 8.
• [728] Use of mRNA expression to detect the induction of drug metabolising enzymes in rat and human hepatocytes. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):86-96.
• [729] Induction of human cytochrome P450 3A enzymes in cultured placental cells by thalidomide and relevance to bioactivation and toxicity. J Toxicol Sci. 2017;42(3):343-348.
• [730] Induction of hepatic CYP3A enzymes by pregnancy-related hormones: studies in human hepatocytes and hepatic cell lines. Drug Metab Dispos. 2013 Feb;41(2):281-90.
• [731] Transcriptomic analysis of human primary bronchial epithelial cells after chloropicrin treatment. Chem Res Toxicol. 2015 Oct 19;28(10):1926-35.
• [732] Filamin A phosphorylation by Akt promotes cell migration in response to arsenic. Oncotarget. 2015 May 20;6(14):12009-19. doi: 10.18632/oncotarget.3617.
• [733] Proteomic analysis of human adipose tissue after rosiglitazone treatment shows coordinated changes to promote glucose uptake. Obesity (Silver Spring). 2010 Jan;18(1):27-34. doi: 10.1038/oby.2009.208. Epub 2009 Jun 25.
• [734] Distinctive profiles of gene expression in the human nucleus accumbens associated with cocaine and heroin abuse. Neuropsychopharmacology. 2006 Oct;31(10):2304-12. doi: 10.1038/sj.npp.1301089. Epub 2006 May 3.
• [735] Clinical determinants of response to irinotecan-based therapy derived from cell line models. Clin Cancer Res. 2008 Oct 15;14(20):6647-55.
• [736] Real-time monitoring of cisplatin-induced cell death. PLoS One. 2011;6(5):e19714. doi: 10.1371/journal.pone.0019714. Epub 2011 May 16.
• [737] Molecular mechanisms controlling the rate and specificity of catechol O-methylation by human soluble catechol O-methyltransferase. Mol Pharmacol. 2001 Feb;59(2):393-402. doi: 10.1124/mol.59.2.393.
• [738] Effects of modafinil on the sleep EEG depend on Val158Met genotype of COMT. Sleep. 2010 Aug;33(8):1027-35. doi: 10.1093/sleep/33.8.1027.
• [739] Tolcapone increases plasma catecholamine levels in patients with Parkinson's disease. Parkinsonism Relat Disord. 2001 Apr;7(2):93-96. doi: 10.1016/s1353-8020(00)00027-4.
• [740] High folic acid increases cell turnover and lowers differentiation and iron content in human HT29 colon cancer cells. Br J Nutr. 2008 Apr;99(4):703-8.
• [741] The genomic response of a human uterine endometrial adenocarcinoma cell line to 17alpha-ethynyl estradiol. Toxicol Sci. 2009 Jan;107(1):40-55.
• [742] Identification of estrogen-induced genes downregulated by AhR agonists in MCF-7 breast cancer cells using suppression subtractive hybridization. Gene. 2001 Jan 10;262(1-2):207-14. doi: 10.1016/s0378-1119(00)00530-8.
• [743] Rapamycin sensitizes multiple myeloma cells to apoptosis induced by dexamethasone. Blood. 2004 Apr 15;103(8):3138-47. doi: 10.1182/blood-2003-05-1543. Epub 2003 Dec 24.
• [744] Antidepressant drug sertraline modulates AMPK-MTOR signaling-mediated autophagy via targeting mitochondrial VDAC1 protein. Autophagy. 2021 Oct;17(10):2783-2799. doi: 10.1080/15548627.2020.1841953. Epub 2020 Nov 9.
• [745] EGFR tyrosine kinase inhibitors activate autophagy as a cytoprotective response in human lung cancer cells. PLoS One. 2011;6(6):e18691. doi: 10.1371/journal.pone.0018691. Epub 2011 Jun 2.
• [746] Oxidative stress induces parallel autophagy and mitochondria dysfunction in human glioma U251 cells. Toxicol Sci. 2009 Aug;110(2):376-88. doi: 10.1093/toxsci/kfp101. Epub 2009 May 18.
• [747] Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J. 2000 Oct 1;351(Pt 1):95-105.
• [748] SU5416 inhibited VEGF and HIF-1alpha expression through the PI3K/AKT/p70S6K1 signaling pathway. Biochem Biophys Res Commun. 2004 Nov 12;324(2):471-80. doi: 10.1016/j.bbrc.2004.09.082.
• [749] D-glucosamine down-regulates HIF-1alpha through inhibition of protein translation in DU145 prostate cancer cells. Biochem Biophys Res Commun. 2009 Apr 24;382(1):96-101. doi: 10.1016/j.bbrc.2009.02.129. Epub 2009 Feb 28.
• [750] Arsenic trioxide inhibits translation of mRNA of bcr-abl, resulting in attenuation of Bcr-Abl levels and apoptosis of human leukemia cells. Cancer Res. 2003 Nov 15;63(22):7950-8.
• [751] The differential effects of neuroleptic drugs and PACAP on the expression of BDNF mRNA and protein in a human glioblastoma cell line. Acta Neurobiol Exp (Wars). 2017;77(3):205-213.
• [752] Tea polyphenols ameliorates neural redox imbalance and mitochondrial dysfunction via mechanisms linking the key circadian regular Bmal1. Food Chem Toxicol. 2017 Dec;110:189-199. doi: 10.1016/j.fct.2017.10.031. Epub 2017 Oct 20.
• [753] LncRNA SNHG12 ameliorates bupivacaine-induced neurotoxicity by sponging miR-497-5p to upregulate NLRX1. Hum Exp Toxicol. 2022 Jan-Dec;41:9603271221089001. doi: 10.1177/09603271221089001.
• [754] Mechanism of arsenic trioxide inhibiting angiogenesis in multiple myeloma. J Huazhong Univ Sci Technolog Med Sci. 2006;26(1):43-6. doi: 10.1007/BF02828035.
• [755] Characterization of arsenic trioxide resistant clones derived from Jurkat leukemia T cell line: focus on PI3K/Akt signaling pathway. Chem Biol Interact. 2013 Oct 5;205(3):198-211. doi: 10.1016/j.cbi.2013.07.011. Epub 2013 Aug 2.
• [756] A systems biology understanding of the synergistic effects of arsenic sulfide and Imatinib in BCR/ABL-associated leukemia. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3378-83.
• [757] Cisplatin transiently up-regulates hHR23 expression through enhanced translational efficiency in A549 adenocarcinoma cells. Toxicol Lett. 2011 Sep 10;205(3):341-50. doi: 10.1016/j.toxlet.2011.06.028. Epub 2011 Jul 2.
• [758] In vitro dual effect of arsenic trioxide on hemopoiesis: inhibition of erythropoiesis and stimulation of megakaryocytic maturation. Blood Cells Mol Dis. 2006 Jan-Feb;36(1):59-76. doi: 10.1016/j.bcmd.2005.10.005. Epub 2005 Dec 15.
• [759] Phenolic metabolites of benzene inhibited the erythroid differentiation of K562 cells. Toxicol Lett. 2011 Jun 24;203(3):190-9. doi: 10.1016/j.toxlet.2011.03.012. Epub 2011 Mar 23.
• [760] The nonsteroidal anti-inflammatory drugs aspirin and indomethacin attenuate beta-catenin/TCF-4 signaling. Oncogene. 2001 Feb 1;20(5):645-53. doi: 10.1038/sj.onc.1204123.
• [761] Novel mechanism of cannabidiol-induced apoptosis in breast cancer cell lines. Breast. 2018 Oct;41:34-41. doi: 10.1016/j.breast.2018.06.009. Epub 2018 Jun 22.
• [762] Cross-talk between non-genomic and genomic signalling pathways--distinct effect profiles of environmental estrogens. Toxicol Appl Pharmacol. 2010 Jun 1;245(2):160-70. doi: 10.1016/j.taap.2010.02.015. Epub 2010 Mar 4.
• [763] Resveratrol attenuates senescence of adipose-derived mesenchymal stem cells and restores their paracrine effects on promoting insulin secretion of INS-1 cells through Pim-1. Eur Rev Med Pharmacol Sci. 2016;20(6):1203-13.
• [764] Cell cycle effects of nonsteroidal anti-inflammatory drugs and enhanced growth inhibition in combination with gemcitabine in pancreatic carcinoma cells. J Pharmacol Exp Ther. 2001 Sep;298(3):976-85.
• [765] Identification of genes linked to gefitinib treatment in prostate cancer cell lines with or without resistance to androgen: a clue to application of gefitinib to hormone-resistant prostate cancer. Oncol Rep. 2006 Jun;15(6):1453-60.
• [766] Chromium III histidinate exposure modulates gene expression in HaCaT human keratinocytes exposed to oxidative stress. Biol Trace Elem Res. 2010 Oct;137(1):23-39.
• [767] A dual role of p21waf1/cip1 gene in apoptosis of HEp-2 treated with cisplatin or methotrexate. Cancer Gene Ther. 2008 Sep;15(9):576-90. doi: 10.1038/cgt.2008.28. Epub 2008 May 16.
• [768] Genomic profiling uncovers a molecular pattern for toxicological characterization of mutagens and promutagens in vitro. Toxicol Sci. 2011 Jul;122(1):185-97.
• [769] Quercetin and Its Fermented Extract as a Potential Inhibitor of Bisphenol A-Exposed HT-29 Colon Cancer Cells' Viability. Int J Mol Sci. 2023 Mar 15;24(6):5604. doi: 10.3390/ijms24065604.
• [770] The Effect of GADD45a on Furazolidone-Induced S-Phase Cell-Cycle Arrest in Human Hepatoma G2 Cells. J Biochem Mol Toxicol. 2015 Oct;29(10):489-495. doi: 10.1002/jbt.21719. Epub 2015 Jun 11.
• [771] Signaling pathways involved in induction of GADD45 gene expression and apoptosis by troglitazone in human MCF-7 breast carcinoma cells. Oncogene. 2004 Jun 3;23(26):4614-23. doi: 10.1038/sj.onc.1207598.
• [772] Comprehensive analysis of transcriptomic changes induced by low and high doses of bisphenol A in HepG2 spheroids in vitro and rat liver in vivo. Environ Res. 2019 Jun;173:124-134. doi: 10.1016/j.envres.2019.03.035. Epub 2019 Mar 18.
• [773] Estrogen receptor regulates E2F1 expression to mediate tamoxifen resistance. Mol Cancer Res. 2010 Mar;8(3):343-52. doi: 10.1158/1541-7786.MCR-09-0395. Epub 2010 Mar 9.
• [774] Fluoxetine mediates G0/G1 arrest by inducing functional inhibition of cyclin dependent kinase subunit (CKS)1. Biochem Pharmacol. 2008 May 15;75(10):1924-34. doi: 10.1016/j.bcp.2008.02.013. Epub 2008 Feb 17.
• [775] Troglitazone suppresses cell growth of KU812 cells independently of PPARgamma. Eur J Pharmacol. 2002 Feb 1;436(1-2):7-13. doi: 10.1016/s0014-2999(01)01577-1.
• [776] Retinoic acid regulates cell cycle progression and cell differentiation in human monocytic THP-1 cells. Exp Cell Res. 2004 Jul 1;297(1):68-81. doi: 10.1016/j.yexcr.2004.02.017.
• [777] [P27(Kip1), cyclin E and endogenous TGF-beta1 changes in apoptosis of NB4 cells induced by As(2)O(3) and/or TGF-beta1 and their significance]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2009 Feb;17(1):74-9.
• [778] In-vivo effects of simvastatin and rosuvastatin on global gene expression in peripheral blood leucocytes in a human inflammation model. Pharmacogenet Genomics. 2008 Feb;18(2):109-20.
• [779] Arsenic promotes the COX2/PGE2-SOX2 axis to increase the malignant stemness properties of urothelial cells. Int J Cancer. 2018 Jul 1;143(1):113-126.
• [780] Topotecan and methotrexate alter expression of the apoptosis-related genes BCL2, FAS and BCL2L12 in leukemic HL-60 cells. Biol Chem. 2006 Dec;387(12):1629-33. doi: 10.1515/BC.2006.203.
• [781] Carvedilol prevents epinephrine-induced apoptosis in human coronary artery endothelial cells: modulation of Fas/Fas ligand and caspase-3 pathway. Cardiovasc Res. 2000 Feb;45(3):788-94. doi: 10.1016/s0008-6363(99)00369-7.
• [782] Regulatory role of KEAP1 and NRF2 in PPAR expression and chemoresistance in human non-small-cell lung carcinoma cells. Free Radic Biol Med. 2012 Aug 15;53(4):758-68. doi: 10.1016/j.freeradbiomed.2012.05.041. Epub 2012 Jun 7.
• [783] Polyunsaturated fatty acids synergize with lipid droplet binding thalidomide analogs to induce oxidative stress in cancer cells. Lipids Health Dis. 2010 Jun 2;9:56. doi: 10.1186/1476-511X-9-56.
• [784] Radiation-induced cathepsin S is involved in radioresistance. Int J Cancer. 2009 Apr 15;124(8):1794-801. doi: 10.1002/ijc.24095.
• [785] Valsartan improves adipose tissue function in humans with impaired glucose metabolism: a randomized placebo-controlled double-blind trial. PLoS One. 2012;7(6):e39930. doi: 10.1371/journal.pone.0039930. Epub 2012 Jun 29.
• [786] Synergistic effects of retinoic acid and tamoxifen on human breast cancer cells: proteomic characterization. Exp Cell Res. 2007 Jan 15;313(2):357-68. doi: 10.1016/j.yexcr.2006.10.016. Epub 2006 Oct 25.
• [787] Changes in composition and activities of 26S proteasomes under the action of doxorubicin--apoptosis inductor of erythroleukemic K562 cells. Cell Biol Int. 2007 Apr;31(4):338-48. doi: 10.1016/j.cellbi.2007.01.018. Epub 2007 Jan 21.
• [788] Impact of Heat Shock Protein 90 Inhibition on the Proteomic Profile of Lung Adenocarcinoma as Measured by Two-Dimensional Electrophoresis Coupled with Mass Spectrometry. Cells. 2019 Jul 31;8(8):806. doi: 10.3390/cells8080806.
• [789] Cannabidiol upregulates melanogenesis through CB1 dependent pathway by activating p38 MAPK and p42/44 MAPK. Chem Biol Interact. 2017 Aug 1;273:107-114. doi: 10.1016/j.cbi.2017.06.005. Epub 2017 Jun 7.
• [790] Estrogen and pure antiestrogen fulvestrant (ICI 182 780) augment cell-matrigel adhesion of MCF-7 breast cancer cells through a novel G protein coupled estrogen receptor (GPR30)-to-calpain signaling axis. Toxicol Appl Pharmacol. 2014 Mar 1;275(2):176-81. doi: 10.1016/j.taap.2014.01.005. Epub 2014 Jan 17.
• [791] Inhibition of activator protein 1 by barbiturates is mediated by differential effects on mitogen-activated protein kinases and the small G proteins ras and rac-1. J Pharmacol Exp Ther. 2004 Dec;311(3):1232-40. doi: 10.1124/jpet.104.071332. Epub 2004 Jul 19.
• [792] Growth of hormone-dependent MCF-7 breast cancer cells is promoted by constitutive caveolin-1 whose expression is lost in an EGF-R-mediated manner during development of tamoxifen resistance. Breast Cancer Res Treat. 2010 Feb;119(3):575-91. doi: 10.1007/s10549-009-0355-8. Epub 2009 Mar 15.
• [793] Effect of histamine H1 receptor antagonists on TARC/CCL17 and MDC/CCL22 production from CD14+ cells induced by antigenic stimulation in vitro. Int Arch Allergy Immunol. 2011;155(1):38-51. doi: 10.1159/000318720. Epub 2010 Nov 25.
• [794] SIRT3 Mediates the Antioxidant Effect of Hydrogen Sulfide in Endothelial Cells. Antioxid Redox Signal. 2016 Feb 20;24(6):329-43. doi: 10.1089/ars.2015.6331. Epub 2015 Nov 10.
• [795] Curcumin inhibits hypoxia-inducible factor-1 by degrading aryl hydrocarbon receptor nuclear translocator: a mechanism of tumor growth inhibition. Mol Pharmacol. 2006 Nov;70(5):1664-71. doi: 10.1124/mol.106.025817. Epub 2006 Jul 31.
• [796] Single and concerted effects of benzo[a]pyrene and flavonoids on the AhR and Nrf2-pathway in the human colon carcinoma cell line Caco-2. Toxicol In Vitro. 2011 Apr;25(3):671-83.
• [797] Omeprazole inhibits pancreatic cancer cell invasion through a nongenomic aryl hydrocarbon receptor pathway. Chem Res Toxicol. 2015 May 18;28(5):907-18.
• [798] Ligand-independent activation of AhR by hydroquinone mediates benzene-induced hematopoietic toxicity. Chem Biol Interact. 2022 Mar 1;355:109845. doi: 10.1016/j.cbi.2022.109845. Epub 2022 Feb 4.
• [799] Inhibition of 5alpha-reductase enhances testosterone-induced expression of U19/Eaf2 tumor suppressor during the regrowth of LNCaP xenograft tumor in nude mice. Prostate. 2010 Oct 1;70(14):1575-85. doi: 10.1002/pros.21193.
• [800] Valproic acid promotes mitochondrial dysfunction in primary human hepatocytes in vitro; impact of C/EBP-controlled gene expression. Arch Toxicol. 2020 Oct;94(10):3463-3473. doi: 10.1007/s00204-020-02835-x. Epub 2020 Jul 4.
• [801] Role of oxidative stress in the induction of metallothionein-2A and heme oxygenase-1 gene expression by the antineoplastic agent gallium nitrate in human lymphoma cells. Free Radic Biol Med. 2008 Sep 15;45(6):763-72.
• [802] Proteomics investigation of protein expression changes in ouabain induced apoptosis in human umbilical vein endothelial cells. J Cell Biochem. 2008 Jun 1;104(3):1054-64. doi: 10.1002/jcb.21691.
• [803] Astaxanthin and omega-3 fatty acids individually and in combination protect against oxidative stress via the Nrf2-ARE pathway. Food Chem Toxicol. 2013 Dec;62:869-75.
• [804] Simulation of interindividual differences in inactivation of reactive para-benzoquinone imine metabolites of diclofenac by glutathione S-transferases in human liver cytosol. Toxicol Lett. 2016 Jul 25;255:52-62.
• [805] Expression of glutathione S-transferase M2 in stage I/II non-small cell lung cancer and alleviation of DNA damage exposure to benzo[a]pyrene. Toxicol Lett. 2010 Feb 15;192(3):316-23. doi: 10.1016/j.toxlet.2009.11.003. Epub 2009 Nov 10.
• [806] Synergistic effects of arsenic trioxide combined with ascorbic acid in human osteosarcoma MG-63 cells: a systems biology analysis. Eur Rev Med Pharmacol Sci. 2014;18(24):3877-88.
• [807] Interactive gene expression pattern in prostate cancer cells exposed to phenolic antioxidants. Life Sci. 2002 Mar 1;70(15):1821-39.
• [808] Differential expression of genes induced by resveratrol in LNCaP cells: P53-mediated molecular targets. Int J Cancer. 2003 Mar 20;104(2):204-12.
• [809] Protective effects of S-carvedilol on doxorubicin-induced damages to human umbilical vein endothelial cells and rats. J Appl Toxicol. 2019 Aug;39(8):1233-1244. doi: 10.1002/jat.3809. Epub 2019 May 7.
• [810] Hydrogen peroxide decreases endothelial nitric oxide synthase promoter activity through the inhibition of Sp1 activity. DNA Cell Biol. 2009 Mar;28(3):119-29.
• [811] Simvastatin inhibits cigarette smoking-induced emphysema and pulmonary hypertension in rat lungs. Am J Respir Crit Care Med. 2005 Oct 15;172(8):987-93. doi: 10.1164/rccm.200501-041OC. Epub 2005 Jul 7.
• [812] A blend of polyphenolic compounds explains the stimulatory effect of red wine on human endothelial NO synthase. Nitric Oxide. 2005 Mar;12(2):97-104.
• [813] The thiazolidinedione drug troglitazone up-regulates nitric oxide synthase expression in vascular endothelial cells. J Diabetes Complications. 2006 Sep-Oct;20(5):336-42.
• [814] Fructose induces the inflammatory molecule ICAM-1 in endothelial cells. J Am Soc Nephrol. 2008 Sep;19(9):1712-20.
• [815] Upregulation of nitric oxide production in vascular endothelial cells by all-trans retinoic acid through the phosphoinositide 3-kinase/Akt pathway. Circulation. 2005 Aug 2;112(5):727-36. doi: 10.1161/CIRCULATIONAHA.104.500959. Epub 2005 Jul 25.
• [816] The THP-1 cell toolbox: a new concept integrating the key events of skin sensitization. Arch Toxicol. 2019 Apr;93(4):941-951.
• [817] Identification of novel low-dose bisphenol a targets in human foreskin fibroblast cells derived from hypospadias patients. PLoS One. 2012;7(5):e36711. doi: 10.1371/journal.pone.0036711. Epub 2012 May 4.
• [818] Unique transcriptome, pathways, and networks in the human endometrial fibroblast response to progesterone in endometriosis. Biol Reprod. 2011 Apr;84(4):801-15.
• [819] Quercetin induces the expression of peroxiredoxins 3 and 5 via the Nrf2/NRF1 transcription pathway. Invest Ophthalmol Vis Sci. 2011 Feb 22;52(2):1055-63. doi: 10.1167/iovs.10-5777.
• [820] Downregulation of the c-MYC target gene, peroxiredoxin III, contributes to arsenic trioxide-induced apoptosis in acute promyelocytic leukemia. Int J Cancer. 2009 Jul 15;125(2):264-75. doi: 10.1002/ijc.24341.
• [821] Differential protein expression of peroxiredoxin I and II by benzo(a)pyrene and quercetin treatment in 22Rv1 and PrEC prostate cell lines. Toxicol Appl Pharmacol. 2007 Apr 15;220(2):197-210. doi: 10.1016/j.taap.2006.12.030. Epub 2007 Jan 9.
• [822] Proteomic analysis of the nucleus accumbens of rats with different vulnerability to cocaine addiction. Neuropharmacology. 2009 Jul;57(1):41-8. doi: 10.1016/j.neuropharm.2009.04.005. Epub 2009 Apr 22.
• [823] Involvement of the p38 MAPK signaling pathway in S-phase cell-cycle arrest induced by Furazolidone in human hepatoma G2 cells. J Appl Toxicol. 2013 Dec;33(12):1500-5. doi: 10.1002/jat.2829. Epub 2012 Oct 30.
• [824] Thiazolidinediones inhibit proliferation of microvascular and macrovascular cells by a PPARgamma-independent mechanism. Diabetologia. 2005 Mar;48(3):586-94. doi: 10.1007/s00125-005-1672-z. Epub 2005 Feb 24.
• [825] Retinoid targeting of different D-type cyclins through distinct chemopreventive mechanisms. Cancer Res. 2005 Jul 15;65(14):6476-83. doi: 10.1158/0008-5472.CAN-05-0370.
• [826] Downregulation of TACO gene transcription restricts mycobacterial entry/survival within human macrophages. FEMS Microbiol Lett. 2005 Sep 1;250(1):137-44. doi: 10.1016/j.femsle.2005.06.056.
• [827] Low-dose methotrexate inhibits methionine S-adenosyltransferase in vitro and in vivo. Mol Med. 2012 May 9;18:423-32.
• [828] Ethanol inhibits methionine adenosyltransferase II activity and S-adenosylmethionine biosynthesis and enhances caspase-3-dependent cell death in T lymphocytes: relevance to alcohol-induced immunosuppression. J Nutr Biochem. 2008 Jun;19(6):384-91.
• [829] Inhibition of cholesterol metabolism underlies synergy between mTOR pathway inhibition and chloroquine in bladder cancer cells. Oncogene. 2016 Aug 25;35(34):4518-28. doi: 10.1038/onc.2015.511. Epub 2016 Feb 8.
• [830] Nicotine-induced survival signaling in lung cancer cells is dependent on their p53 status while its down-regulation by curcumin is independent. Mol Cancer. 2010 Aug 20;9:220.
• [831] Dihydromyricetin suppresses tumor growth via downregulation of the EGFR/Akt/survivin signaling pathway. J Biochem Mol Toxicol. 2023 Jun;37(6):e23328. doi: 10.1002/jbt.23328. Epub 2023 Feb 19.
• [832] Effect of toll-like receptor 7 and 9 targeted therapy to prevent the development of hepatocellular carcinoma. Liver Int. 2015 Mar;35(3):1063-76. doi: 10.1111/liv.12626. Epub 2014 Jul 30.
• [833] Alcohol inhibits cell-cell adhesion mediated by human L1. J Cell Biol. 1996 Apr;133(2):381-90. doi: 10.1083/jcb.133.2.381.
• [834] Dissecting progressive stages of 5-fluorouracil resistance in vitro using RNA expression profiling. Int J Cancer. 2004 Nov 1;112(2):200-12. doi: 10.1002/ijc.20401.
• [835] Clinical response to Nabiximols correlates with the downregulation of immune pathways in multiple sclerosis. Eur J Neurol. 2018 Jul;25(7):934-e70. doi: 10.1111/ene.13623. Epub 2018 Apr 16.
• [836] Casodex treatment induces hypoxia-related gene expression in the LNCaP prostate cancer progression model. BMC Urol. 2005 Mar 24;5:5.
• [837] Atrazine potentiation of arsenic trioxide-induced cytotoxicity and gene expression in human liver carcinoma cells (HepG2). Mol Cell Biochem. 2001 Jun;222(1-2):49-59.
• [838] Sulindac suppresses beta-catenin expression in human cancer cells. Eur J Pharmacol. 2008 Mar 31;583(1):26-31. doi: 10.1016/j.ejphar.2007.12.034. Epub 2008 Feb 5.
• [839] Arsenic trioxide and 2-methoxyestradiol reduce beta-catenin accumulation after proteasome inhibition and enhance the sensitivity of myeloma cells to Bortezomib. Leuk Res. 2008 Nov;32(11):1674-83. doi: 10.1016/j.leukres.2008.03.039. Epub 2008 May 15.
• [840] Effect of aspirin on the Wnt/beta-catenin pathway is mediated via protein phosphatase 2A. Oncogene. 2006 Oct 19;25(49):6447-56. doi: 10.1038/sj.onc.1209658. Epub 2006 Jul 31.
• [841] Benzene metabolite hydroquinone induces apoptosis of bone marrow mononuclear cells through inhibition of -catenin signaling. Toxicol In Vitro. 2018 Feb;46:361-369. doi: 10.1016/j.tiv.2017.08.018. Epub 2017 Sep 5.
• [842] Anthelmintic Niclosamide Disrupts the Interplay of p65 and FOXM1/-catenin and Eradicates Leukemia Stem Cells in Chronic Myelogenous Leukemia. Clin Cancer Res. 2017 Feb 1;23(3):789-803. doi: 10.1158/1078-0432.CCR-16-0226. Epub 2016 Aug 4.
• [843] Cannabinoids synergize with carfilzomib, reducing multiple myeloma cells viability and migration. Oncotarget. 2016 Nov 22;7(47):77543-77557. doi: 10.18632/oncotarget.12721.
• [844] Distinct genetic profile in peripheral blood mononuclear cells of psoriatic arthritis patients treated with methotrexate and TNF-inhibitors. Clin Rheumatol. 2014 Dec;33(12):1815-21. doi: 10.1007/s10067-014-2807-8. Epub 2014 Oct 24.
• [845] [Inhibitory effect of arsenic trioxide on invasion in human hepatocellular carcinoma SMMC-7721 cells and its mechanism]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2012 Dec;28(12):1254-7.
• [846] Induction of CCAAT/enhancer-binding protein-homologous protein by cigarette smoke through the superoxide anion-triggered PERK-eIF2 pathway. Toxicology. 2011 Sep 5;287(1-3):105-12. doi: 10.1016/j.tox.2011.06.005. Epub 2011 Jun 15.
• [847] High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities. Arch Toxicol. 2017 Mar;91(3):1367-1383. doi: 10.1007/s00204-016-1781-0. Epub 2016 Jun 29.
• [848] Utilization of causal reasoning of hepatic gene expression in rats to identify molecular pathways of idiosyncratic drug-induced liver injury. Toxicol Sci. 2014 Jan;137(1):234-48. doi: 10.1093/toxsci/kft232. Epub 2013 Oct 17.
• [849] Dose- and time-dependent transcriptional response of Ishikawa cells exposed to genistein. Toxicol Sci. 2016 May;151(1):71-87.
• [850] SU5416, a small molecule tyrosine kinase receptor inhibitor, has biologic activity in patients with refractory acute myeloid leukemia or myelodysplastic syndromes. Blood. 2003 Aug 1;102(3):795-801. doi: 10.1182/blood-2002-10-3023. Epub 2003 Mar 20.
• [851] Low dosage of arsenic trioxide (As(2)O(3)) inhibits angiogenesis in epithelial ovarian cancer without cell apoptosis. J Biol Inorg Chem. 2018 Aug;23(6):939-947. doi: 10.1007/s00775-018-1595-z. Epub 2018 Jul 16.
• [852] Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas. Cancer Res. 2004 Aug 15;64(16):5617-23. doi: 10.1158/0008-5472.CAN-03-3927.
• [853] Inhibition of endothelial cell proliferation and angiogenesis by orlistat, a fatty acid synthase inhibitor. FASEB J. 2006 Oct;20(12):2027-35. doi: 10.1096/fj.05-5404com.
• [854] Ornithine decarboxylase antizyme upregulates DNA-dependent protein kinase and enhances the nonhomologous end-joining repair of DNA double-strand breaks in human oral cancer cells. Biochemistry. 2007 Aug 7;46(31):8920-32. doi: 10.1021/bi7000328. Epub 2007 Jul 14.
• [855] Induction of heme oxygenase-1 by cobalt protoporphyrin enhances the antitumour effect of bortezomib in adult T-cell leukaemia cells. Br J Cancer. 2007 Oct 22;97(8):1099-105. doi: 10.1038/sj.bjc.6604003. Epub 2007 Sep 25.
• [856] The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat Genet. 2009 Feb;41(2):178-186.
• [857] BET bromodomain inhibition of MYC-amplified medulloblastoma. Clin Cancer Res. 2014 Feb 15;20(4):912-25.
• [858] Glucocorticoids induce G1 arrest of lymphoblastic cells through retinoblastoma protein Rb1 dephosphorylation in childhood acute lymphoblastic leukemia in vivo. Cancer Biol Ther. 2004 May;3(5):470-6. doi: 10.4161/cbt.3.5.838. Epub 2004 May 9.
• [859] Proteomic analysis of antiproliferative effects by treatment of 5-fluorouracil in cervical cancer cells. DNA Cell Biol. 2004 Nov;23(11):769-76.
• [860] Isobaric tags for relative and absolute quantitation-based proteomics analysis of the effect of ginger oil on bisphenol A-induced breast cancer cell proliferation. Oncol Lett. 2021 Feb;21(2):101. doi: 10.3892/ol.2020.12362. Epub 2020 Dec 8.
• [861] Diesel exhaust particulate-induced activation of Stat3 requires activities of EGFR and Src in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2007 Feb;292(2):L422-9. doi: 10.1152/ajplung.00204.2006. Epub 2006 Oct 6.
• [862] Physapubescin B enhances the sensitivity of gastric cancer cells to trametinib by inhibiting the STAT3 signaling pathway. Toxicol Appl Pharmacol. 2020 Dec 1;408:115273. doi: 10.1016/j.taap.2020.115273. Epub 2020 Oct 6.
• [863] Sulindac induces apoptosis and inhibits tumor growth in vivo in head and neck squamous cell carcinoma. Neoplasia. 2007 Mar;9(3):192-9. doi: 10.1593/neo.06781.
• [864] Simvastatin acts as an inhibitor of interferon gamma-induced cycloxygenase-2 expression in human THP-1 cells, but not in murine RAW264.7 cells. Biocell. 2009 Aug;33(2):107-14.
• [865] Therapeutic potential of cladribine in combination with STAT3 inhibitor against multiple myeloma. BMC Cancer. 2011 Jun 16;11:255. doi: 10.1186/1471-2407-11-255.
• [866] Targeting multiple cannabinoid anti-tumour pathways with a resorcinol derivative leads to inhibition of advanced stages of breast cancer. Br J Pharmacol. 2014 Oct;171(19):4464-77. doi: 10.1111/bph.12803. Epub 2014 Sep 5.
• [867] Study of As(2)O(3) regulating proliferation and apoptosis of Tca8113 cells by inhibiting the expression of Id-1. Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):1932-1937. doi: 10.1080/21691401.2019.1613419.
• [868] Pyrethroid insecticides influence the signal transduction in T helper lymphocytes from atopic and nonatopic subjects. Inflamm Res. 2003 Apr;52(4):154-63. doi: 10.1007/s000110300066.
• [869] Direct and indirect effects of retinoic acid on human Th2 cytokine and chemokine expression by human T lymphocytes. BMC Immunol. 2006 Nov 21;7:27. doi: 10.1186/1471-2172-7-27.
• [870] Cannabinoid receptor type 2 agonists induce transcription of the mu-opioid receptor gene in Jurkat T cells. Mol Pharmacol. 2006 Apr;69(4):1486-91. doi: 10.1124/mol.105.018325. Epub 2006 Jan 24.
• [871] THC Treatment Alters Glutamate Receptor Gene Expression in Human Stem Cell-Derived Neurons. Mol Neuropsychiatry. 2017 Nov;3(2):73-84. doi: 10.1159/000477762. Epub 2017 Jul 20.
• [872] Cocaine-induced alterations in nucleus accumbens ionotropic glutamate receptor subunits in human and non-human primates. J Neurochem. 2005 Dec;95(6):1785-93. doi: 10.1111/j.1471-4159.2005.03517.x.
• [873] Disruption of glutamate neurotransmitter transmission is modulated by SNAP-25 in benzo[a]pyrene-induced neurotoxic effects. Toxicology. 2017 Jun 1;384:11-22. doi: 10.1016/j.tox.2017.03.021. Epub 2017 Apr 19.
• [874] Epigenetic siRNA and chemical screens identify SETD8 inhibition as a therapeutic strategy for p53 activation in high-risk neuroblastoma. Cancer Cell. 2017 Jan 9;31(1):50-63.
• [875] Type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase (AKR1C3): role in breast cancer and inhibition by non-steroidal anti-inflammatory drug analogs. Chem Biol Interact. 2009 Mar 16;178(1-3):221-7.
• [876] Substrate specificity of human 3(20)alpha-hydroxysteroid dehydrogenase for neurosteroids and its inhibition by benzodiazepines. Biol Pharm Bull. 2002 Apr;25(4):441-5.
• [877] Progestins as inhibitors of the human 20-ketosteroid reductases, AKR1C1 and AKR1C3. Chem Biol Interact. 2011 May 30;191(1-3):227-33.
• [878] AKR1C3 as a potential target for the inhibitory effect of dietary flavonoids. Chem Biol Interact. 2009 Mar 16;178(1-3):138-44.
• [879] The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer. J Med Chem. 2008 Sep 25;51(18):5522-32. doi: 10.1021/jm800295d.
• [880] Cantharidin suppresses gastric cancer cell migration/invasion by inhibiting the PI3K/Akt signaling pathway via CCAT1. Chem Biol Interact. 2020 Feb 1;317:108939. doi: 10.1016/j.cbi.2020.108939. Epub 2020 Jan 13.
• [881] Atorvastatin induces MicroRNA-145 expression in HEPG2 cells via regulation of the PI3K/AKT signalling pathway. Chem Biol Interact. 2018 May 1;287:32-40. doi: 10.1016/j.cbi.2018.04.005. Epub 2018 Apr 6.
• [882] eIF4E is a critical regulator of human papillomavirus (HPV)-immortalized cervical epithelial (H8) cell growth induced by nicotine. Toxicology. 2019 May 1;419:1-10. doi: 10.1016/j.tox.2019.02.017. Epub 2019 Mar 2.
• [883] Repression of Kisspeptin1 weakens hydrogen peroxide-caused injury in HTR8 cells via adjusting PI3K/AKT/mTOR pathway. J Biochem Mol Toxicol. 2020 May;34(5):e22461. doi: 10.1002/jbt.22461. Epub 2020 Feb 11.
• [884] Quercetin inhibits angiogenesis mediated human prostate tumor growth by targeting VEGFR- 2 regulated AKT/mTOR/P70S6K signaling pathways. PLoS One. 2012;7(10):e47516. doi: 10.1371/journal.pone.0047516. Epub 2012 Oct 18.
• [885] Hydroquinone-induced endoplasmic reticulum stress affects TK6 cell autophagy and apoptosis via ATF6-mTOR. Environ Toxicol. 2023 Aug;38(8):1874-1890. doi: 10.1002/tox.23814. Epub 2023 May 6.
• [886] Benzo[a]pyrene-induced changes in microRNA-mRNA networks. Chem Res Toxicol. 2012 Apr 16;25(4):838-49.
• [887] Regulation of chromatin assembly and cell transformation by formaldehyde exposure in human cells. Environ Health Perspect. 2017 Sep 21;125(9):097019.
• [888] Translational control of glial glutamate transporter EAAT2 expression. J Biol Chem. 2007 Jan 19;282(3):1727-37. doi: 10.1074/jbc.M609822200. Epub 2006 Nov 30.
• [889] Rifampin Regulation of Drug Transporters Gene Expression and the Association of MicroRNAs in Human Hepatocytes. Front Pharmacol. 2016 Apr 26;7:111.
• [890] Human nasal olfactory epithelium as a dynamic marker for CNS therapy development. Exp Neurol. 2011 Dec;232(2):203-11. doi: 10.1016/j.expneurol.2011.09.002. Epub 2011 Sep 16.
• [891] Gene alterations of ovarian cancer cells expressing estrogen receptors by estrogen and bisphenol a using microarray analysis. Lab Anim Res. 2011 Jun;27(2):99-107. doi: 10.5625/lar.2011.27.2.99. Epub 2011 Jun 22.
• [892] Identification of NR4A2 as a transcriptional activator of IL-8 expression in human inflammatory arthritis. Mol Immunol. 2009 Oct;46(16):3345-57. doi: 10.1016/j.molimm.2009.07.019. Epub 2009 Sep 3.
• [893] Identification of cornifelin and early growth response-1 gene as novel biomarkers for in vitro eye irritation using a 3D reconstructed human cornea model MCTT HCE?. Arch Toxicol. 2015 Sep;89(9):1589-98. doi: 10.1007/s00204-014-1390-8. Epub 2014 Nov 7.
• [894] Inhibition of nicotinamide phosphoribosyltransferase and depletion of nicotinamide adenine dinucleotide contribute to arsenic trioxide suppression of oral squamous cell carcinoma. Toxicol Appl Pharmacol. 2017 Sep 15;331:54-61. doi: 10.1016/j.taap.2017.05.008. Epub 2017 May 10.
• [895] Rosiglitazone inhibits alpha4 nicotinic acetylcholine receptor expression in human lung carcinoma cells through peroxisome proliferator-activated receptor gamma-independent signals. Mol Cancer Ther. 2009 Jan;8(1):110-8. doi: 10.1158/1535-7163.MCT-08-0719.
• [896] The C terminus of the human nicotinic alpha4beta2 receptor forms a binding site required for potentiation by an estrogenic steroid. J Neurosci. 2001 Sep 1;21(17):6561-8. doi: 10.1523/JNEUROSCI.21-17-06561.2001.
• [897] Effect of menstrual cycle and hormonal treatment on ki-67 and bcl-2 expression and adenomyosis. Gynecol Endocrinol. 2005 Mar;20(3):127-31. doi: 10.1080/09513590400021086.
• [898] Mitophagy inhibits proliferation by decreasing cyclooxygenase-2 (COX-2) in arsenic trioxide-treated HepG2 cells. Environ Toxicol Pharmacol. 2016 Jul;45:212-21.
• [899] Establishment and characterization of a novel imatinib-sensitive chronic myeloid leukemia cell line MYL, and an imatinib-resistant subline MYL-R showing overexpression of Lyn. Eur J Haematol. 2007 May;78(5):417-31. doi: 10.1111/j.1600-0609.2007.00835.x.
• [900] Cotreatment with vorinostat (suberoylanilide hydroxamic acid) enhances activity of dasatinib (BMS-354825) against imatinib mesylate-sensitive or imatinib mesylate-resistant chronic myelogenous leukemia cells. Clin Cancer Res. 2006 Oct 1;12(19):5869-78. doi: 10.1158/1078-0432.CCR-06-0980.
• [901] Sorafenib induces apoptosis specifically in cells expressing BCR/ABL by inhibiting its kinase activity to activate the intrinsic mitochondrial pathway. Cancer Res. 2009 May 1;69(9):3927-36. doi: 10.1158/0008-5472.CAN-08-2978. Epub 2009 Apr 14.
• [902] Efficacy of the polo-like kinase inhibitor rigosertib, alone or in combination with Abelson tyrosine kinase inhibitors, against break point cluster region-c-Abelson-positive leukemia cells. Oncotarget. 2015 Aug 21;6(24):20231-40. doi: 10.18632/oncotarget.4047.
• [903] Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018 Nov;121:214-223. doi: 10.1016/j.fct.2018.08.034. Epub 2018 Aug 26.
• [904] Methotrexate increases expression of cell cycle checkpoint genes via JNK activation. Arthritis Rheum. 2012 Jun;64(6):1780-9. doi: 10.1002/art.34342. Epub 2011 Dec 19.
• [905] Simvastatin inhibits growth via apoptosis and the induction of cell cycle arrest in human melanoma cells. Melanoma Res. 2008 Apr;18(2):85-94. doi: 10.1097/CMR.0b013e3282f60097.
• [906] Effects of structurally related flavonoids on cell cycle progression of human melanoma cells: regulation of cyclin-dependent kinases CDK2 and CDK1. Biochem Pharmacol. 2001 May 15;61(10):1205-15. doi: 10.1016/s0006-2952(01)00583-4.
• [907] Induction mechanism of apoptosis by troglitazone through peroxisome proliferator-activated receptor-gamma in gastric carcinoma cells. Anticancer Res. 2003 Jan-Feb;23(1A):267-73.
• [908] Down-regulation of CD44 contributes to the differentiation of HL-60 cells induced by ATRA or HMBA. Cell Mol Immunol. 2007 Feb;4(1):59-63.
• [909] The molecular basis of genistein-induced mitotic arrest and exit of self-renewal in embryonal carcinoma and primary cancer cell lines. BMC Med Genomics. 2008 Oct 10;1:49.
• [910] Low-dose Bisphenol A exposure alters the functionality and cellular environment in a human cardiomyocyte model. Environ Pollut. 2023 Oct 15;335:122359. doi: 10.1016/j.envpol.2023.122359. Epub 2023 Aug 9.
• [911] Tyrosine phosphorylation of the scaffold protein IQGAP1 in the MET pathway alters function. J Biol Chem. 2020 Dec 25;295(52):18105-18121. doi: 10.1074/jbc.RA120.015891. Epub 2020 Oct 21.
• [912] Blood cell oxidative stress precedes hemolysis in whole blood-liver slice co-cultures of rat, dog, and human tissues. Toxicol Appl Pharmacol. 2010 May 1;244(3):354-65. doi: 10.1016/j.taap.2010.01.017. Epub 2010 Feb 6.
• [913] Induction of multidrug resistance proteins MRP1 and MRP3 and gamma-glutamylcysteine synthetase gene expression by nonsteroidal anti-inflammatory drugs in human colon cancer cells. Biochem Biophys Res Commun. 2002 Feb 8;290(5):1427-33. doi: 10.1006/bbrc.2002.6367.
• [914] Flavonoids increase the intracellular glutathione level by transactivation of the gamma-glutamylcysteine synthetase catalytical subunit promoter. Free Radic Biol Med. 2002 Mar 1;32(5):386-93. doi: 10.1016/s0891-5849(01)00812-7.
• [915] Glycidamide and cis-2-butene-1,4-dial (BDA) as potential carcinogens and promoters of liver cancer - An in vitro study. Food Chem Toxicol. 2022 Aug;166:113251. doi: 10.1016/j.fct.2022.113251. Epub 2022 Jun 21.
• [916] Essential role of Nrf2 in keratinocyte protection from UVA by quercetin. Biochem Biophys Res Commun. 2009 Sep 11;387(1):109-14. doi: 10.1016/j.bbrc.2009.06.136. Epub 2009 Jul 1.
• [917] An in vitro skin sensitization assay termed EpiSensA for broad sets of chemicals including lipophilic chemicals and pre/pro-haptens. Toxicol In Vitro. 2017 Apr;40:11-25. doi: 10.1016/j.tiv.2016.12.005. Epub 2016 Dec 10.
• [918] PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells. J Exp Med. 2006 Oct 2;203(10):2351-62.
• [919] Regulation of Hepatic Cholesteryl Ester Transfer Protein Expression and Reverse Cholesterol Transport by Inhibition of DNA Topoisomerase II. J Biol Chem. 2015 Jun 5;290(23):14418-29. doi: 10.1074/jbc.M115.643015. Epub 2015 Apr 25.
• [920] Zinc inhibits oxidative stress-induced iron signaling and apoptosis in Caco-2 cells. Free Radic Biol Med. 2010 Apr 1;48(7):961-8. doi: 10.1016/j.freeradbiomed.2010.01.019. Epub 2010 Jan 20.
• [921] Influence of estrogens on copper indicators: in vivo and in vitro studies. Biol Trace Elem Res. 2010 Jun;134(3):252-64.
• [922] Organochloride pesticides induced hepatic ABCG5/G8 expression and lipogenesis in Chinese patients with gallstone disease. Oncotarget. 2016 Jun 7;7(23):33689-702. doi: 10.18632/oncotarget.9399.
• [923] Effect of atorvastatin, simvastatin, and lovastatin on the metabolism of cholesterol and triacylglycerides in HepG2 cells. Biochem Pharmacol. 2001 Dec 1;62(11):1545-55. doi: 10.1016/s0006-2952(01)00790-0.
• [924] Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells. Exp Eye Res. 2009 Dec;89(6):995-1002. doi: 10.1016/j.exer.2009.08.011. Epub 2009 Sep 1.
• [925] Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):245-55.
• [926] Synergistic interaction of lovastatin and paclitaxel in human cancer cells. Mol Cancer Ther. 2001 Dec;1(2):141-9.
• [927] Systematic transcriptome-based comparison of cellular adaptive stress response activation networks in hepatic stem cell-derived progeny and primary human hepatocytes. Toxicol In Vitro. 2021 Jun;73:105107. doi: 10.1016/j.tiv.2021.105107. Epub 2021 Feb 3.
• [928] Adenosine and Cordycepin Accelerate Tissue Remodeling Process through Adenosine Receptor Mediated Wnt/-Catenin Pathway Stimulation by Regulating GSK3b Activity. Int J Mol Sci. 2021 May 25;22(11):5571. doi: 10.3390/ijms22115571.
• [929] Regulation of secretases by all-trans-retinoic acid. FEBS J. 2009 May;276(9):2645-55. doi: 10.1111/j.1742-4658.2009.06992.x. Epub 2009 Mar 25.
• [930] Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. Genome Res. 2012 Nov;22(11):2153-62.
• [931] Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models. Cancer Res. 2001 Oct 15;61(20):7456-63.
• [932] The role of NAD(+)-dependent isocitrate dehydrogenase 3 subunit in AFB1 induced liver lesion. Toxicol Lett. 2014 Jan 30;224(3):371-9. doi: 10.1016/j.toxlet.2013.10.037. Epub 2013 Nov 5.
• [933] Identification of potential biomarkers for predicting acute dermal irritation by proteomic analysis. J Appl Toxicol. 2011 Nov;31(8):762-72.
• [934] Identification of Compounds That Inhibit Estrogen-Related Receptor Alpha Signaling Using High-Throughput Screening Assays. Molecules. 2019 Feb 27;24(5):841. doi: 10.3390/molecules24050841.
• [935] Characterization of human liver thermostable phenol sulfotransferase (SULT1A1) allozymes with 3,3',5-triiodothyronine as the substrate. J Endocrinol. 2001 Dec;171(3):525-32.
• [936] Enzymatic characterization and interspecies difference of phenol sulfotransferases, ST1A forms. Drug Metab Dispos. 2001 Mar;29(3):274-81.
• [937] Sulfation of benzyl alcohol by the human cytosolic sulfotransferases (SULTs): a systematic analysis. J Appl Toxicol. 2016 Sep;36(9):1090-4.
• [938] Inhibition of human phenol and estrogen sulfotransferase by certain non-steroidal anti-inflammatory agents. Curr Drug Metab. 2006 Oct;7(7):745-53.
• [939] Methotrexate induction of human sulfotransferases in Hep G2 and Caco-2 cells. J Appl Toxicol. 2005 Sep-Oct;25(5):354-60.
• [940] Gene expression profiling of breast cancer cells in response to gemcitabine: NF-kappaB pathway activation as a potential mechanism of resistance. Breast Cancer Res Treat. 2007 Apr;102(2):157-72.
• [941] Coordinate up-regulation of TMEM97 and cholesterol biosynthesis genes in normal ovarian surface epithelial cells treated with progesterone: implications for pathogenesis of ovarian cancer. BMC Cancer. 2007 Dec 11;7:223.
• [942] Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures. Arch Toxicol. 2018 Jun;92(6):1939-1952.
• [943] Resveratrol induces Notch2-mediated apoptosis and suppression of neuroendocrine markers in medullary thyroid cancer. Ann Surg Oncol. 2011 May;18(5):1506-11. doi: 10.1245/s10434-010-1488-z. Epub 2010 Dec 24.
• [944] Regulation of aryl hydrocarbon receptor function by selective estrogen receptor modulators. Mol Endocrinol. 2010 Jan;24(1):33-46.
• [945] Effects of paclitaxel on proliferation and apoptosis in human acute myeloid leukemia HL-60 cells. Acta Pharmacol Sin. 2004 Mar;25(3):378-84.
• [946] Increased processing of APLP2 and APP with concomitant formation of APP intracellular domains in BDNF and retinoic acid-differentiated human neuroblastoma cells. J Neurochem. 2005 Nov;95(4):1059-68. doi: 10.1111/j.1471-4159.2005.03440.x. Epub 2005 Sep 7.
• [947] MAT1-modulated cyclin-dependent kinase-activating kinase activity cross-regulates neuroblastoma cell G1 arrest and neurite outgrowth. Cancer Res. 2004 May 1;64(9):2977-83. doi: 10.1158/0008-5472.can-03-4018.
• [948] Effects of valproic acid and levetiracetam on viability and cell cycle regulatory genes expression in the OVCAR-3 cell line. Pharmacol Rep. 2012;64(1):157-65. doi: 10.1016/s1734-1140(12)70742-9.
• [949] Hydroxyurea (HU)-induced apoptosis in the mouse fetal lung. Exp Mol Pathol. 2005 Aug;79(1):59-67. doi: 10.1016/j.yexmp.2005.02.007. Epub 2005 Apr 22.
• [950] Application of cDNA microarray to the study of arsenic-induced liver diseases in the population of Guizhou, China. Toxicol Sci. 2001 Jan;59(1):185-92.
• [951] The analysis of doxorubicin resistance in human breast cancer cells using antibody microarrays. Mol Cancer Ther. 2006 Aug;5(8):2115-20. doi: 10.1158/1535-7163.MCT-06-0190.
• [952] BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia. Blood. 2012 Oct 4;120(14):2843-52.
• [953] Gene-expression profiling during curcumin-induced apoptosis reveals downregulation of CXCR4. Exp Hematol. 2007 Jan;35(1):84-95.
• [954] The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells. Leukemia. 2009 Jun;23(6):1019-28.
• [955] Aspirin and alterations in DNA repair proteins in the SW480 colorectal cancer cell line. Oncol Rep. 2010 Jul;24(1):37-46. doi: 10.3892/or_00000826.
• [956] A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs. Biochem J. 2004 Dec 1;384(Pt 2):391-400. doi: 10.1042/BJ20041498.
• [957] Phosphorylation and stabilization of topoisomerase II protein by p38 mitogen-activated protein kinase sensitize breast cancer cells to its poisons. J Biol Chem. 2011 Oct 14;286(41):35883-35890. doi: 10.1074/jbc.M111.229260. Epub 2011 Aug 30.
• [958] Effects of lithium and valproic acid on gene expression and phenotypic markers in an NT2 neurosphere model of neural development. PLoS One. 2013;8(3):e58822.
• [959] Differential expression of microRNAs and their predicted targets in renal cells exposed to amphotericin B and its complex with copper (II) ions. Toxicol Mech Methods. 2017 Sep;27(7):537-543. doi: 10.1080/15376516.2017.1333554. Epub 2017 Jun 8.
• [960] Gene expression changes associated with altered growth and differentiation in benzo[a]pyrene or arsenic exposed normal human epidermal keratinocytes. J Appl Toxicol. 2008 May;28(4):491-508.
• [961] A model to identify novel targets involved in oxidative stress-induced apoptosis in human lung epithelial cells by RNA interference. Toxicol In Vitro. 2010 Feb;24(1):310-8. doi: 10.1016/j.tiv.2009.08.008. Epub 2009 Aug 23.
• [962] Nitric oxide inhibits execution of apoptosis at two distinct ATP-dependent steps upstream and downstream of mitochondrial cytochrome c release. Biochem Biophys Res Commun. 1999 Apr 29;258(1):215-21. doi: 10.1006/bbrc.1999.0491.
• [963] Palmitate increases the susceptibility of cells to drug-induced toxicity: an in vitro method to identify drugs with potential contraindications in patients with metabolic disease. Toxicol Sci. 2012 Oct;129(2):346-62. doi: 10.1093/toxsci/kfs208. Epub 2012 Jun 14.
• [964] Simvastatin induces apoptosis and alters cytoskeleton in endometrial stromal cells. J Clin Endocrinol Metab. 2010 Jul;95(7):3453-9. doi: 10.1210/jc.2010-0072. Epub 2010 Apr 28.
• [965] Combination of Poly I:C and arsenic trioxide triggers apoptosis synergistically via activation of TLR3 and mitochondrial pathways in hepatocellular carcinoma cells. Cell Biol Int. 2011 Aug;35(8):803-10. doi: 10.1042/CBI20100739.
• [966] Role of mitochondria in aspirin-induced apoptosis in human gastric epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2005 Oct;289(4):G731-8. doi: 10.1152/ajpgi.00150.2005. Epub 2005 Jun 23.
• [967] p38 MAPK/PP2Ac/TTP pathway on the connection of TNF- and caspases activation on hydroquinone-induced apoptosis. Carcinogenesis. 2013 Apr;34(4):818-27. doi: 10.1093/carcin/bgs409. Epub 2013 Jan 3.
• [968] Growth inhibition of ovarian tumor-initiating cells by niclosamide. Mol Cancer Ther. 2012 Aug;11(8):1703-12.
• [969] Transcriptome responses in blood reveal distinct biological pathways associated with arsenic exposure through drinking water in rural settings of Punjab, Pakistan. Environ Int. 2020 Feb;135:105403. doi: 10.1016/j.envint.2019.105403. Epub 2019 Dec 18.
• [970] New insights into the mechanisms underlying 5-fluorouracil-induced intestinal toxicity based on transcriptomic and metabolomic responses in human intestinal organoids. Arch Toxicol. 2021 Aug;95(8):2691-2718. doi: 10.1007/s00204-021-03092-2. Epub 2021 Jun 20.
• [971] Molecular mechanisms of quercitrin-induced apoptosis in non-small cell lung cancer. Arch Med Res. 2014 Aug;45(6):445-54.
• [972] Prevention of murine experimental corneal trauma by epigenetic events regulating claudin 6 and claudin 9. Jpn J Ophthalmol. 2008 May-Jun;52(3):195-203. doi: 10.1007/s10384-008-0524-z. Epub 2008 Jul 27.
• [973] Evidence for a role of claudin 2 as a proximal tubular stress responsive paracellular water channel. Toxicol Appl Pharmacol. 2014 Sep 1;279(2):163-72.
• [974] Induction of intestinalization in human esophageal keratinocytes is a multistep process. Carcinogenesis. 2009 Jan;30(1):122-30. doi: 10.1093/carcin/bgn227. Epub 2008 Oct 8.
• [975] Resveratrol induces chemosensitization to 5-fluorouracil through up-regulation of intercellular junctions, Epithelial-to-mesenchymal transition and apoptosis in colorectal cancer. Biochem Pharmacol. 2015 Nov 1;98(1):51-68. doi: 10.1016/j.bcp.2015.08.105. Epub 2015 Aug 24.
• [976] Redox/methylation mediated abnormal DNA methylation as regulators of ambient fine particulate matter-induced neurodevelopment related impairment in human neuronal cells. Sci Rep. 2016 Sep 14;6:33402. doi: 10.1038/srep33402.
• [977] Early Transcriptomic Changes upon Thalidomide Exposure Influence the Later Neuronal Development in Human Embryonic Stem Cell-Derived Spheres. Int J Mol Sci. 2020 Aug 3;21(15):5564. doi: 10.3390/ijms21155564.
• [978] Proteomics analysis of the proliferative effect of low-dose ouabain on human endothelial cells. Biol Pharm Bull. 2007 Feb;30(2):247-53. doi: 10.1248/bpb.30.247.
• [979] Protein profile in neuroblastoma cells incubated with S- and R-enantiomers of ibuprofen by iTRAQ-coupled 2-D LC-MS/MS analysis: possible action of induced proteins on Alzheimer's disease. Proteomics. 2008 Apr;8(8):1595-607. doi: 10.1002/pmic.200700556.
• [980] Analysis of gene expression induced by diethylstilbestrol (DES) in human primitive Mullerian duct cells using microarray. Cancer Lett. 2005 Apr 8;220(2):197-210.
• [981] Arsenic trioxide inhibits CXCR4-mediated metastasis by interfering miR-520h/PP2A/NF-B signaling in cervical cancer. Ann Surg Oncol. 2014 Dec;21 Suppl 4:S687-95. doi: 10.1245/s10434-014-3812-5. Epub 2014 Jul 22.
• [982] Etodolac induces apoptosis and inhibits cell adhesion to bone marrow stromal cells in human myeloma cells. Leuk Res. 2006 Feb;30(2):123-35. doi: 10.1016/j.leukres.2005.06.009. Epub 2005 Jul 25.
• [983] Hypermethylation of the somatostatin promoter is a common, early event in human esophageal carcinogenesis. Cancer. 2008 Jan 1;112(1):43-9. doi: 10.1002/cncr.23135.
• [984] A genomic approach to predict synergistic combinations for breast cancer treatment. Pharmacogenomics J. 2013 Feb;13(1):94-104. doi: 10.1038/tpj.2011.48. Epub 2011 Nov 15.
• [985] Quantitative proteomics and transcriptomics addressing the estrogen receptor subtype-mediated effects in T47D breast cancer cells exposed to the phytoestrogen genistein. Mol Cell Proteomics. 2011 Jan;10(1):M110.002170.
• [986] A prospective evaluation of ifosfamide-related nephrotoxicity in children and young adults. Cancer. 1995 Dec 15;76(12):2557-64. doi: 10.1002/1097-0142(19951215)76:12<2557::aid-cncr2820761223>3.0.co;2-9.
• [987] Serum clara-cell protein and beta2-microglobulin as early markers of occupational exposure to nitric oxides. Inhal Toxicol. 2005 Feb;17(2):87-97. doi: 10.1080/08958370590899460.
• [988] Effects of aspirin on metastasis-associated gene expression detected by cDNA microarray. Acta Pharmacol Sin. 2004 Oct;25(10):1327-33.
• [989] Changes of bone markers during long-term intravenous calcitriol therapy in maintenance dialysis patients. Miner Electrolyte Metab. 1996;22(4):219-23.
• [990] Pamidronate increases markers of bone formation in patients with multiple myeloma in plateau phase under interferon-alpha treatment. Calcif Tissue Int. 2001 May;68(5):285-90.
• [991] Molecular targets of chloropicrin in human airway epithelial cells. Toxicol In Vitro. 2017 Aug;42:247-254.
• [992] Quantitative Assessment of Arsenite-Induced Perturbation of Ubiquitinated Proteome. Chem Res Toxicol. 2022 Sep 19;35(9):1589-1597. doi: 10.1021/acs.chemrestox.2c00197. Epub 2022 Aug 22.
• [993] Combination of atorvastatin and celecoxib synergistically induces cell cycle arrest and apoptosis in colon cancer cells. Int J Cancer. 2008 May 1;122(9):2115-24. doi: 10.1002/ijc.23315.
• [994] Cannabidiol Reduces Leukemic Cell Size - But Is It Important?. Front Pharmacol. 2017 Mar 24;8:144. doi: 10.3389/fphar.2017.00144. eCollection 2017.
• [995] Crizotinib-resistant mutants of EML4-ALK identified through an accelerated mutagenesis screen. Chem Biol Drug Des. 2011 Dec;78(6):999-1005. doi: 10.1111/j.1747-0285.2011.01239.x. Epub 2011 Oct 31.
• [996] Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling. Aging (Albany NY). 2012 Dec;4(12):952-65. doi: 10.18632/aging.100521.
• [997] Androgen receptor-mTOR crosstalk is regulated by testosterone availability: implication for prostate cancer cell survival. Anticancer Res. 2010 Oct;30(10):3895-901.
• [998] ST1926, a novel and orally active retinoid-related molecule inducing apoptosis in myeloid leukemia cells: modulation of intracellular calcium homeostasis. Blood. 2004 Jan 1;103(1):194-207.
• [999] Analysis of the prostate cancer cell line LNCaP transcriptome using a sequencing-by-synthesis approach. BMC Genomics. 2006 Sep 29;7:246. doi: 10.1186/1471-2164-7-246.
• [1000] Simvastatin and lovastatin inhibit breast cell invasion induced by H-Ras. Oncol Rep. 2009 May;21(5):1317-22. doi: 10.3892/or_00000357.
• [1001] Genome-wide analysis of BEAS-2B cells exposed to trivalent arsenicals and dimethylthioarsinic acid. Toxicology. 2010 Jan 31;268(1-2):31-9.
• [1002] Identification of flucloxacillin-modified hepatocellular proteins: implications in flucloxacillin-induced liver injury. Toxicol Sci. 2023 Mar 20;192(1):106-116. doi: 10.1093/toxsci/kfad015.
• [1003] Orlistat 120 mg improves glycaemic control in type 2 diabetic patients with or without concurrent weight loss. Diabetes Obes Metab. 2009 Apr;11(4):361-71. doi: 10.1111/j.1463-1326.2008.00970.x. Epub 2009 Jan 22.
• [1004] Gene expression responses reflecting 5-FU-induced toxicity: Comparison between patient colon tissue and 3D human colon organoids. Toxicol Lett. 2022 Dec 1;371:17-24. doi: 10.1016/j.toxlet.2022.09.013. Epub 2022 Sep 29.
• [1005] The MT1G Gene in LUHMES Neurons Is a Sensitive Biomarker of Neurotoxicity. Neurotox Res. 2020 Dec;38(4):967-978. doi: 10.1007/s12640-020-00272-3. Epub 2020 Sep 1.
• [1006] DNA methyltransferase inhibitors coordinately induce expression of the human reelin and glutamic acid decarboxylase 67 genes. Mol Pharmacol. 2007 Mar;71(3):644-53. doi: 10.1124/mol.106.030635. Epub 2006 Oct 25.
• [1007] Gene expression profiling in Ishikawa cells: a fingerprint for estrogen active compounds. Toxicol Appl Pharmacol. 2009 Apr 1;236(1):85-96.
• [1008] Gene expression in benzene-exposed workers by microarray analysis of peripheral mononuclear blood cells: induction and silencing of CYP4F3A and regulation of DNA-dependent protein kinase catalytic subunit in DNA double strand break repair. Chem Biol Interact. 2010 Mar 19;184(1-2):207-11.
• [1009] Expression of connective tissue growth factor, a biomarker in senescence of human diploid fibroblasts, is up-regulated by a transforming growth factor-beta-mediated signaling pathway. Biochem Biophys Res Commun. 2004 Jun 11;318(4):819-25. doi: 10.1016/j.bbrc.2004.04.108.
• [1010] Suppression of transforming growth factor beta/smad signaling in keloid-derived fibroblasts by quercetin: implications for the treatment of excessive scars. J Trauma. 2004 Nov;57(5):1032-7. doi: 10.1097/01.ta.0000114087.46566.eb.
• [1011] The retinoid anticancer signal: mechanisms of target gene regulation. Br J Cancer. 2005 Aug 8;93(3):310-8. doi: 10.1038/sj.bjc.6602700.
• [1012] Inhibition of TGF-/SMAD3/NF-B signaling by microRNA-491 is involved in arsenic trioxide-induced anti-angiogenesis in hepatocellular carcinoma cells. Toxicol Lett. 2014 Nov 18;231(1):55-61. doi: 10.1016/j.toxlet.2014.08.024. Epub 2014 Sep 6.
• [1013] Identification and Profiling of Environmental Chemicals That Inhibit the TGF/SMAD Signaling Pathway. Chem Res Toxicol. 2019 Dec 16;32(12):2433-2444. doi: 10.1021/acs.chemrestox.9b00228. Epub 2019 Nov 11.
• [1014] Characterization of the Molecular Alterations Induced by the Prolonged Exposure of Normal Colon Mucosa and Colon Cancer Cells to Low-Dose Bisphenol A. Int J Mol Sci. 2022 Oct 1;23(19):11620. doi: 10.3390/ijms231911620.
• [1015] Modulation of FoxO signaling in human hepatoma cells by exposure to copper or zinc ions. Arch Biochem Biophys. 2006 Oct 15;454(2):107-13. doi: 10.1016/j.abb.2006.08.016. Epub 2006 Aug 30.
• [1016] Regulation of ERRalpha gene expression by estrogen receptor agonists and antagonists in SKBR3 breast cancer cells: differential molecular mechanisms mediated by g protein-coupled receptor GPR30/GPER-1. Mol Endocrinol. 2010 May;24(5):969-80. doi: 10.1210/me.2009-0148. Epub 2010 Mar 8.
• [1017] Effects of gonadotrophin-releasing hormone agonists on apoptosis of granulosa cells. Ann N Y Acad Sci. 2005 May;1042:531-7. doi: 10.1196/annals.1338.065.
• [1018] K-RAS transformation in prostate epithelial cell overcomes H2O2-induced apoptosis via upregulation of gamma-glutamyltransferase-2. Toxicol In Vitro. 2012 Apr;26(3):429-34. doi: 10.1016/j.tiv.2012.01.013. Epub 2012 Jan 17.
• [1019] Troglitazone induces cytotoxicity in part by promoting the degradation of peroxisome proliferator-activated receptor co-activator-1 protein. Br J Pharmacol. 2010 Oct;161(4):771-81. doi: 10.1111/j.1476-5381.2010.00900.x.
• [1020] Under ambient UVA exposure, pefloxacin exhibits both immunomodulatory and genotoxic effects via multiple mechanisms. J Photochem Photobiol B. 2018 Jan;178:593-605. doi: 10.1016/j.jphotobiol.2017.12.014. Epub 2017 Dec 15.
• [1021] Genistein-induced neuronal differentiation is associated with activation of extracellular signal-regulated kinases and upregulation of p21 and N-cadherin. J Cell Biochem. 2005 Dec 1;96(5):1061-70. doi: 10.1002/jcb.20626.
• [1022] Mechanisms of thymidine kinase/ganciclovir and cytosine deaminase/ 5-fluorocytosine suicide gene therapy-induced cell death in glioma cells. Oncogene. 2005 Feb 10;24(7):1231-43. doi: 10.1038/sj.onc.1208290.
• [1023] In vitro antioxidant and antigenotoxic potentials of 3,5-O-di-galloylquinic acid extracted from Myrtus communis leaves and modulation of cell gene expression by H2O2. J Appl Toxicol. 2012 May;32(5):333-41.
• [1024] HMG-CoA reductase inhibitors, statins, induce phosphorylation of Mdm2 and attenuate the p53 response to DNA damage. FASEB J. 2005 Mar;19(3):476-8. doi: 10.1096/fj.04-2745fje. Epub 2004 Dec 29.
• [1025] Amifostine impairs p53-mediated apoptosis of human myeloid leukemia cells. Mol Cancer Ther. 2003 Sep;2(9):893-900.
• [1026] Suppression of breast cancer by chemical modulation of vulnerable zinc fingers in estrogen receptor. Nat Med. 2004 Jan;10(1):40-7. doi: 10.1038/nm969. Epub 2003 Dec 14.
• [1027] Impact of extracellular folate levels on global gene expression. Mol Pharmacol. 2001 Dec;60(6):1288-95. doi: 10.1124/mol.60.6.1288.
• [1028] Thyroid hormone responsive genes in cultured human fibroblasts. J Clin Endocrinol Metab. 2005 Feb;90(2):936-43.
• [1029] Molecular characterization of a toxicological tipping point during human stem cell differentiation. Reprod Toxicol. 2020 Jan;91:1-13. doi: 10.1016/j.reprotox.2019.10.001. Epub 2019 Oct 7.
• [1030] Effect of prenatal arsenic exposure on DNA methylation and leukocyte subpopulations in cord blood. Epigenetics. 2014 May;9(5):774-82. doi: 10.4161/epi.28153. Epub 2014 Feb 13.
• [1031] Functional characterization of N-octyl 4-methylamphetamine variants and related bivalent compounds at the dopamine and serotonin transporters using Ca(2+) channels as sensors. Toxicol Appl Pharmacol. 2021 May 15;419:115513. doi: 10.1016/j.taap.2021.115513. Epub 2021 Mar 27.
• [1032] Dopamine transporter gene associated with diminished subjective response to amphetamine. Neuropsychopharmacology. 2005 Mar;30(3):602-9. doi: 10.1038/sj.npp.1300637.
• [1033] Pharmacological Chaperones of the Dopamine Transporter Rescue Dopamine Transporter Deficiency Syndrome Mutations in Heterologous Cells. J Biol Chem. 2016 Oct 14;291(42):22053-22062. doi: 10.1074/jbc.M116.749119. Epub 2016 Aug 23.
• [1034] Evaluation of first generation synthetic cannabinoids on binding at non-cannabinoid receptors and in a battery of in?vivo assays in mice. Neuropharmacology. 2016 Nov;110(Pt A):143-153. doi: 10.1016/j.neuropharm.2016.07.016. Epub 2016 Jul 20.
• [1035] Pharmacological characterization of the aminorex analogs 4-MAR, 4,4'-DMAR, and 3,4-DMAR. Neurotoxicology. 2019 May;72:95-100. doi: 10.1016/j.neuro.2019.02.011. Epub 2019 Feb 15.
• [1036] Pyrethroid pesticide-induced alterations in dopamine transporter function. Toxicol Appl Pharmacol. 2006 Mar 15;211(3):188-97. doi: 10.1016/j.taap.2005.06.003. Epub 2005 Jul 11.
• [1037] In vitro detection of drug-induced phospholipidosis using gene expression and fluorescent phospholipid based methodologies. Toxicol Sci. 2007 Sep;99(1):162-73.
• [1038] Differentiation of human embryonic stem cells into smooth muscle cells in adherent monolayer culture. Biochem Biophys Res Commun. 2006 Dec 15;351(2):321-7. doi: 10.1016/j.bbrc.2006.09.171. Epub 2006 Oct 17.
• [1039] Riboflavin depletion impairs cell proliferation in adult human duodenum: identification of potential effectors. Dig Dis Sci. 2011 Apr;56(4):1007-19. doi: 10.1007/s10620-010-1374-3. Epub 2010 Sep 17.
• [1040] Inhibition of phosphatidylinostol 3-kinase uncouples H2O2-induced senescent phenotype and cell cycle arrest in normal human diploid fibroblasts. Exp Cell Res. 2004 Aug 1;298(1):188-96. doi: 10.1016/j.yexcr.2004.04.012.
• [1041] Combination of all-trans retinoic acid and paclitaxel-induced differentiation and apoptosis in human glioblastoma U87MG xenografts in nude mice. Cancer. 2008 Feb 1;112(3):596-607. doi: 10.1002/cncr.23223.
• [1042] Characterization of cell death induced by ethacrynic acid in a human colon cancer cell line DLD-1 and suppression by N-acetyl-L-cysteine. Cancer Sci. 2003 Oct;94(10):886-93.
• [1043] Dominant roles of the Raf/MEK/ERK pathway in cell cycle progression, prevention of apoptosis and sensitivity to chemotherapeutic drugs. Cell Cycle. 2010 Apr 15;9(8):1629-38. doi: 10.4161/cc.9.8.11487. Epub 2010 Apr 15.
• [1044] Functional characterization of peroxisome proliferator-activated receptor-/ expression in colon cancer. Mol Carcinog. 2011 Nov;50(11):884-900. doi: 10.1002/mc.20757. Epub 2011 Mar 11.
• [1045] Aspirin-induced apoptosis in jurkat cells is not mediated by peroxisome proliferator-activated receptor delta. Mol Cell Biochem. 2004 Nov;266(1-2):57-63. doi: 10.1023/b:mcbi.0000049138.67699.7b.
• [1046] (9)-Tetrahydrocannabinol upregulates fatty acid 2-hydroxylase (FA2H) via PPAR induction: A possible evidence for the cancellation of PPAR/-mediated inhibition of PPAR in MDA-MB-231?cells. Arch Biochem Biophys. 2019 Feb 15;662:219-225. doi: 10.1016/j.abb.2018.12.011. Epub 2018 Dec 13.
• [1047] Cross-talk between vitamin D receptor (VDR)- and peroxisome proliferator-activated receptor (PPAR)-signaling in melanoma cells. Anticancer Res. 2009 Sep;29(9):3647-58.
• [1048] Suppression of RAGE as a basis of simvastatin-dependent plaque stabilization in type 2 diabetes. Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2716-23.
• [1049] Prevention of deoxycholate-induced gastric apoptosis by aspirin: roles of NF-kappaB and PKC signaling. J Surg Res. 2008 Mar;145(1):66-73. doi: 10.1016/j.jss.2007.04.039. Epub 2007 Jul 20.
• [1050] Peroxisome proliferator-activated receptor-gamma agonists inhibit respiratory syncytial virus-induced expression of intercellular adhesion molecule-1 in human lung epithelial cells. Immunology. 2007 May;121(1):71-81. doi: 10.1111/j.1365-2567.2006.02539.x.
• [1051] Glucosamine regulation of LPS-mediated inflammation in human bronchial epithelial cells. Eur J Pharmacol. 2010 Jun 10;635(1-3):219-26. doi: 10.1016/j.ejphar.2010.02.044. Epub 2010 Mar 20.
• [1052] Effects of 1 alpha,25-dihydroxy-vitamin D3 and calcipotriol on organotypic cultures of outer root sheath cells: a potential model to evaluate antipsoriatic drugs. Arch Dermatol Res. 1993;285(7):402-9. doi: 10.1007/BF00372133.
• [1053] Toxicoproteomics reveals an effect of clozapine on autophagy in human liver spheroids. Toxicol Mech Methods. 2023 Jun;33(5):401-410. doi: 10.1080/15376516.2022.2156005. Epub 2022 Dec 19.
• [1054] Cleavage of focal adhesion kinase is an early marker and modulator of oxidative stress-induced apoptosis. Chem Biol Interact. 2008 Jan 10;171(1):57-66. doi: 10.1016/j.cbi.2007.08.009. Epub 2007 Aug 19.
• [1055] Effect of all-trans retinoic acid on sodium/iodide symporter expression, radioiodine uptake and gene expression profiles in a human anaplastic thyroid carcinoma cell line. Nucl Med Biol. 2006 Oct;33(7):875-82. doi: 10.1016/j.nucmedbio.2006.07.004.
• [1056] Activation of cannabinoid receptors promote periodontal cell adhesion and migration. J Clin Periodontol. 2019 Dec;46(12):1264-1272. doi: 10.1111/jcpe.13190. Epub 2019 Oct 22.
• [1057] Monomeric and oligomeric flavanols are agonists of membrane androgen receptors. Exp Cell Res. 2005 Oct 1;309(2):329-39. doi: 10.1016/j.yexcr.2005.06.011.
• [1058] Disruption of FAK signaling: a side mechanism in cytotoxicity. Toxicology. 2008 Mar 12;245(1-2):1-10. doi: 10.1016/j.tox.2007.12.003. Epub 2007 Dec 15.
• [1059] Novel ATP-competitive Akt inhibitor afuresertib suppresses the proliferation of malignant pleural mesothelioma cells. Cancer Med. 2017 Nov;6(11):2646-2659. doi: 10.1002/cam4.1179. Epub 2017 Sep 27.
• [1060] Combining kallistatin gene therapy and meloxicam to treat hepatocellular carcinoma in mice. Cancer Sci. 2009 Nov;100(11):2226-33. doi: 10.1111/j.1349-7006.2009.01306.x. Epub 2009 Aug 4.
• [1061] Expression of the retinoic acid-metabolizing enzyme CYP26A1 limits programmed cell death. Mol Pharmacol. 2005 May;67(5):1808-17. doi: 10.1124/mol.104.005769. Epub 2005 Feb 9.
• [1062] Role of BAX in the apoptotic response to anticancer agents. Science. 2000 Nov 3;290(5493):989-92. doi: 10.1126/science.290.5493.989.
• [1063] The role of MITF and Mcl-1 proteins in the antiproliferative and proapoptotic effect of ciprofloxacin in amelanotic melanoma cells: In silico and in vitro study. Toxicol In Vitro. 2020 Aug;66:104884. doi: 10.1016/j.tiv.2020.104884. Epub 2020 May 8.
• [1064] Quercetin downregulates Mcl-1 by acting on mRNA stability and protein degradation. Br J Cancer. 2011 Jul 12;105(2):221-30. doi: 10.1038/bjc.2011.229.
• [1065] Anti-cancer properties of glucosamine-hydrochloride in YD-8 human oral cancer cells: Induction of the caspase-dependent apoptosis and down-regulation of HIF-1. Toxicol In Vitro. 2012 Feb;26(1):42-50. doi: 10.1016/j.tiv.2011.10.005. Epub 2011 Oct 13.
• [1066] Long-term estrogen exposure promotes carcinogen bioactivation, induces persistent changes in gene expression, and enhances the tumorigenicity of MCF-7 human breast cancer cells. Toxicol Appl Pharmacol. 2009 Nov 1;240(3):355-66.
• [1067] BRD4 is a novel therapeutic target for liver fibrosis. Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):15713-8. doi: 10.1073/pnas.1522163112. Epub 2015 Dec 7.
• [1068] Histone Acetyltransferase p300/CREB-binding Protein-associated Factor (PCAF) Is Required for All-trans-retinoic Acid-induced Granulocytic Differentiation in Leukemia Cells. J Biol Chem. 2017 Feb 17;292(7):2815-2829. doi: 10.1074/jbc.M116.745398. Epub 2017 Jan 4.
• [1069] Highly active combination of BRD4 antagonist and histone deacetylase inhibitor against human acute myelogenous leukemia cells. Mol Cancer Ther. 2014 May;13(5):1142-54.
• [1070] Nicotine modulates the expression of a diverse set of genes in the neuronal SH-SY5Y cell line. J Biol Chem. 2003 May 2;278(18):15633-40.
• [1071] Identification of biomarkers modulated by the rexinoid LGD1069 (bexarotene) in human breast cells using oligonucleotide arrays. Cancer Res. 2006 Dec 15;66(24):12009-18.
• [1072] Autophagy as a compensation mechanism participates in ethanol-induced fetal adrenal dysfunction in female rats. Toxicol Appl Pharmacol. 2018 Apr 15;345:36-47.
• [1073] Low H3K27 acetylation of SF1 in PBMC: a biomarker for prenatal dexamethasone exposure-caused adrenal insufficiency of steroid synthesis in male offspring. Cell Biol Toxicol. 2023 Oct;39(5):2051-2067. doi: 10.1007/s10565-021-09691-0. Epub 2022 Mar 4.
• [1074] Transcriptional activation of steroidogenic factor-1 by hypomethylation of the 5' CpG island in endometriosis. J Clin Endocrinol Metab. 2007 Aug;92(8):3261-7. doi: 10.1210/jc.2007-0494. Epub 2007 May 22.
• [1075] Stimulating the GPR30 estrogen receptor with a novel tamoxifen analogue activates SF-1 and promotes endometrial cell proliferation. Cancer Res. 2009 Jul 1;69(13):5415-23.
• [1076] Prenatal nicotinic exposure suppresses fetal adrenal steroidogenesis via steroidogenic factor 1 (SF-1) deacetylation. Toxicol Appl Pharmacol. 2014 Jun 15;277(3):231-41.
• [1077] Human steroidogenic factor-1 (hSF-1) regulates progesterone biosynthesis and growth of ovarian surface epithelial cancer cells. J Steroid Biochem Mol Biol. 2010 Mar;119(1-2):14-25. doi: 10.1016/j.jsbmb.2009.11.006. Epub 2010 Jan 4.
• [1078] Activation of the orphan nuclear receptor steroidogenic factor 1 by oxysterols. Proc Natl Acad Sci U S A. 1997 May 13;94(10):4895-900. doi: 10.1073/pnas.94.10.4895.
• [1079] Peroxisome proliferator-activated receptor-gamma mediates bisphenol A inhibition of FSH-stimulated IGF-1, aromatase, and estradiol in human granulosa cells. Environ Health Perspect. 2010 Mar;118(3):400-6. doi: 10.1289/ehp.0901161. Epub 2009 Oct 22.
• [1080] Cannabidiol Induces Cell Cycle Arrest and Cell Apoptosis in Human Gastric Cancer SGC-7901 Cells. Biomolecules. 2019 Jul 25;9(8):302. doi: 10.3390/biom9080302.
• [1081] Correction of ATM gene function by aminoglycoside-induced read-through of premature termination codons. Proc Natl Acad Sci U S A. 2004 Nov 2;101(44):15676-81. doi: 10.1073/pnas.0405155101. Epub 2004 Oct 21.
• [1082] Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP, cIAP2, BCL-XL and survivin. Med Oncol. 2010 Sep;27(3):833-42. doi: 10.1007/s12032-009-9294-9. Epub 2009 Sep 10.
• [1083] Benzodithiophenes potentiate differentiation of acute promyelocytic leukemia cells by lowering the threshold for ligand-mediated corepressor/coactivator exchange with retinoic acid receptor alpha and enhancing changes in all-trans-retinoic acid-regulated gene expression. Cancer Res. 2005 Sep 1;65(17):7856-65. doi: 10.1158/0008-5472.CAN-05-1056.
• [1084] Induction of alkaline phosphatase activity by L-ascorbic acid in human osteoblastic cells: a potential role for CK2 and Ikaros. Nutrition. 2007 Oct;23(10):745-53. doi: 10.1016/j.nut.2007.06.013. Epub 2007 Jul 30.
• [1085] Autophagy Inhibition Overcomes the Antagonistic Effect Between Gefitinib and Cisplatin in Epidermal Growth Factor Receptor Mutant Non--Small-Cell Lung Cancer Cells. Clin Lung Cancer. 2015 Sep;16(5):e55-66. doi: 10.1016/j.cllc.2015.03.006. Epub 2015 Apr 2.
• [1086] Harnessing autophagy to overcome mitogen-activated protein kinase kinase inhibitor-induced resistance in metastatic melanoma. Br J Dermatol. 2019 Feb;180(2):346-356. doi: 10.1111/bjd.17333. Epub 2018 Nov 25.
• [1087] Involvement of mitochondrial dysfunction in nefazodone-induced hepatotoxicity. Food Chem Toxicol. 2016 Aug;94:148-58. doi: 10.1016/j.fct.2016.06.001. Epub 2016 Jun 8.
• [1088] Targeting of EGFR increase?anti-cancer effects of arsenic trioxide: Promising treatment for glioblastoma multiform. Eur J Pharmacol. 2018 Feb 5;820:274-285. doi: 10.1016/j.ejphar.2017.12.041. Epub 2017 Dec 20.
• [1089] An ATM- and Rad3-related (ATR) signaling pathway and a phosphorylation-acetylation cascade are involved in activation of p53/p21Waf1/Cip1 in response to 5-aza-2'-deoxycytidine treatment. J Biol Chem. 2008 Feb 1;283(5):2564-74. doi: 10.1074/jbc.M702454200. Epub 2007 Oct 31.
• [1090] Frenolicin B Targets Peroxiredoxin 1 and Glutaredoxin 3 to Trigger ROS/4E-BP1-Mediated Antitumor Effects. Cell Chem Biol. 2019 Mar 21;26(3):366-377.e12. doi: 10.1016/j.chembiol.2018.11.013. Epub 2019 Jan 17.
• [1091] Arsenic trioxide potentiates the anti-cancer activities of sorafenib against hepatocellular carcinoma by inhibiting Akt activation. Tumour Biol. 2015 Apr;36(4):2323-34. doi: 10.1007/s13277-014-2839-3. Epub 2014 Nov 22.
• [1092] Transcriptional changes common to human cocaine, cannabis and phencyclidine abuse. PLoS One. 2006 Dec 27;1(1):e114. doi: 10.1371/journal.pone.0000114.
• [1093] Endometrial receptivity is affected in women with high circulating progesterone levels at the end of the follicular phase: a functional genomics analysis. Hum Reprod. 2011 Jul;26(7):1813-25.
• [1094] Differentiating human NT2/D1 neurospheres as a versatile in vitro 3D model system for developmental neurotoxicity testing. Toxicology. 2008 Jul 30;249(2-3):243-50. doi: 10.1016/j.tox.2008.05.014. Epub 2008 Jul 2.
• [1095] Prenatal arsenic exposure and shifts in the newborn proteome: interindividual differences in tumor necrosis factor (TNF)-responsive signaling. Toxicol Sci. 2014 Jun;139(2):328-37. doi: 10.1093/toxsci/kfu053. Epub 2014 Mar 27.
• [1096] Histopathologic and immunohistochemical features in human skin after exposure to nitrogen and sulfur mustard. Am J Dermatopathol. 1998 Feb;20(1):22-8. doi: 10.1097/00000372-199802000-00005.
• [1097] Constitutive gene expression predisposes morphogen-mediated cell fate responses of NT2/D1 and 27X-1 human embryonal carcinoma cells. Stem Cells. 2007 Mar;25(3):771-8. doi: 10.1634/stemcells.2006-0271. Epub 2006 Nov 30.
• [1098] Nrf2 but not autophagy inhibition is associated with the survival of wild-type epidermal growth factor receptor non-small cell lung cancer cells. Toxicol Appl Pharmacol. 2016 Nov 1;310:140-149. doi: 10.1016/j.taap.2016.09.010. Epub 2016 Sep 14.
• [1099] Hydroquinone triggers pyroptosis and endoplasmic reticulum stress via AhR-regulated oxidative stress in human lymphocytes. Toxicol Lett. 2023 Mar 1;376:39-50. doi: 10.1016/j.toxlet.2023.01.005. Epub 2023 Jan 13.
• [1100] DNA methylation modifies urine biomarker levels in 1,6-hexamethylene diisocyanate exposed workers: a pilot study. Toxicol Lett. 2014 Dec 1;231(2):217-26. doi: 10.1016/j.toxlet.2014.10.024. Epub 2014 Oct 22.
• [1101] BTG3 tumor suppressor gene promoter demethylation, histone modification and cell cycle arrest by genistein in renal cancer. Carcinogenesis. 2009 Apr;30(4):662-70. doi: 10.1093/carcin/bgp042. Epub 2009 Feb 12.
• [1102] Analysis of estrogen agonism and antagonism of tamoxifen, raloxifene, and ICI182780 in endometrial cancer cells: a putative role for the epidermal growth factor receptor ligand amphiregulin. J Soc Gynecol Investig. 2005 Oct;12(7):e55-67.
• [1103] Modulation of notch signaling pathway to prevent H2O2/menadione-induced SK-N-MC cells death by EUK134. Cell Mol Neurobiol. 2014 Oct;34(7):1037-45. doi: 10.1007/s10571-014-0079-0. Epub 2014 Jul 9.
• [1104] Gene expression in human hippocampus from cocaine abusers identifies genes which regulate extracellular matrix remodeling. PLoS One. 2007 Nov 14;2(11):e1187. doi: 10.1371/journal.pone.0001187.
• [1105] Chronic exposure to arsenic causes increased cell survival, DNA damage, and increased expression of mitochondrial transcription factor A (mtTFA) in human prostate epithelial cells. Chem Res Toxicol. 2011 Mar 21;24(3):340-9. doi: 10.1021/tx1003112. Epub 2011 Jan 14.
• [1106] Natural antioxidants exhibit chemopreventive characteristics through the regulation of CNC b-Zip transcription factors in estrogen-induced breast carcinogenesis. J Biochem Mol Toxicol. 2014 Dec;28(12):529-38.
• [1107] Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells. Nat Commun. 2018 Aug 9;9(1):3069. doi: 10.1038/s41467-018-05402-2.
• [1108] Parathyroid hormone 1-34 reduces dexamethasone-induced terminal differentiation in human articular chondrocytes. Toxicology. 2016 Aug 10;368-369:116-128.
• [1109] Effect of resveratrol on proliferation and apoptosis of human pancreatic cancer MIA PaCa-2 cells may?involve inhibition of the Hedgehog signaling pathway. Mol Med Rep. 2014 Nov;10(5):2563-7. doi: 10.3892/mmr.2014.2511. Epub 2014 Aug 21.
• [1110] Exposure-based assessment of chemical teratogenicity using morphogenetic aggregates of human embryonic stem cells. Reprod Toxicol. 2020 Jan;91:74-91. doi: 10.1016/j.reprotox.2019.10.004. Epub 2019 Nov 8.
• [1111] Global expression profiling of theophylline response genes in macrophages: evidence of airway anti-inflammatory regulation. Respir Res. 2005 Aug 8;6(1):89. doi: 10.1186/1465-9921-6-89.
• [1112] Direct activation of ATM by resveratrol under oxidizing conditions. PLoS One. 2014 Jun 16;9(6):e97969. doi: 10.1371/journal.pone.0097969. eCollection 2014.
• [1113] Genome-wide gene expression profiling of low-dose, long-term exposure of human osteosarcoma cells to bisphenol A and its analogs bisphenols AF and S. Toxicol In Vitro. 2015 Aug;29(5):1060-9.
• [1114] Molecular mechanism of action of bisphenol and bisphenol A mediated by oestrogen receptor alpha in growth and apoptosis of breast cancer cells. Br J Pharmacol. 2013 May;169(1):167-78.
• [1115] An orally bioavailable positive allosteric modulator of the mGlu4 receptor with efficacy in an animal model of motor dysfunction. Bioorg Med Chem Lett. 2010 Aug 15;20(16):4901-5.
• [1116] Transcriptome profile analysis of saturated aliphatic aldehydes reveals carbon number-specific molecules involved in pulmonary toxicity. Chem Res Toxicol. 2014 Aug 18;27(8):1362-70.
• [1117] Preferential induction of the AhR gene battery in HepaRG cells after a single or repeated exposure to heterocyclic aromatic amines. Toxicol Appl Pharmacol. 2010 Nov 15;249(1):91-100.
• [1118] Mutant p53 reactivation by PRIMA-1MET induces multiple signaling pathways converging on apoptosis. Oncogene. 2010 Mar 4;29(9):1329-38. doi: 10.1038/onc.2009.425. Epub 2009 Nov 30.
• [1119] Clarifying off-target effects for torcetrapib using network pharmacology and reverse docking approach. BMC Syst Biol. 2012 Dec 10;6:152.
• [1120] Inter-laboratory comparison of human renal proximal tubule (HK-2) transcriptome alterations due to Cyclosporine A exposure and medium exhaustion. Toxicol In Vitro. 2009 Apr;23(3):486-99.
• [1121] Successful validation of genomic biomarkers for human immunotoxicity in Jurkat T cells in vitro. J Appl Toxicol. 2015 Jul;35(7):831-41.
• [1122] OTX015 (MK-8628), a novel BET inhibitor, displays in vitro and in vivo antitumor effects alone and in combination with conventional therapies in glioblastoma models. Int J Cancer. 2016 Nov 1;139(9):2047-55. doi: 10.1002/ijc.30256. Epub 2016 Jul 30.
• [1123] BET inhibitor OTX015 targets BRD2 and BRD4 and decreases c-MYC in acute leukemia cells. Oncotarget. 2015 Jul 10;6(19):17698-712. doi: 10.18632/oncotarget.4131.
• [1124] Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion. Autophagy. 2018;14(8):1435-1455. doi: 10.1080/15548627.2018.1474314. Epub 2018 Jul 20.
• [1125] Cell-type-specific responses to chemotherapeutics in breast cancer. Cancer Res. 2004 Jun 15;64(12):4218-26.
• [1126] Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells. Arch Toxicol. 2018 Apr;92(4):1507-1524.
• [1127] Characterisation of cisplatin-induced transcriptomics responses in primary mouse hepatocytes, HepG2 cells and mouse embryonic stem cells shows conservation of regulating transcription factor networks. Mutagenesis. 2014 Jan;29(1):17-26.
• [1128] Expression and DNA methylation changes in human breast epithelial cells after bisphenol A exposure. Int J Oncol. 2012 Jul;41(1):369-77.
• [1129] Effects of SIDT2 on the miR-25/NOX4/HuR axis and SIRT3 mRNA stability lead to ROS-mediated TNF- expression in hydroquinone-treated leukemia cells. Cell Biol Toxicol. 2023 Oct;39(5):2207-2225. doi: 10.1007/s10565-022-09705-5. Epub 2022 Mar 18.
• [1130] The p38 MAPK pathway mediates aryl propionic acid induced messenger rna stability of p75 NTR in prostate cancer cells. Cancer Res. 2007 Dec 1;67(23):11402-10. doi: 10.1158/0008-5472.CAN-07-1792.
• [1131] Tyrosine phosphorylation of HuR by JAK3 triggers dissociation and degradation of HuR target mRNAs. Nucleic Acids Res. 2014 Jan;42(2):1196-208. doi: 10.1093/nar/gkt903. Epub 2013 Oct 7.
• [1132] Amsacrine downregulates BCL2L1 expression and triggers apoptosis in human chronic myeloid leukemia cells through the SIDT2/NOX4/ERK/HuR pathway. Toxicol Appl Pharmacol. 2023 Sep 1;474:116625. doi: 10.1016/j.taap.2023.116625. Epub 2023 Jul 13.
• [1133] The intermediate conductance Ca2+-activated K+ channel inhibitor TRAM-34 stimulates proliferation of breast cancer cells via activation of oestrogen receptors. Br J Pharmacol. 2010 Feb 1;159(3):650-8. doi: 10.1111/j.1476-5381.2009.00557.x. Epub 2009 Dec 24.
• [1134] Comprehensive transcriptome profiling of BET inhibitor-treated HepG2 cells. PLoS One. 2022 Apr 29;17(4):e0266966. doi: 10.1371/journal.pone.0266966. eCollection 2022.
• [1135] Increased expression of VDAC1 sensitizes carcinoma cells to apoptosis induced by DNA cross-linking agents. Biochem Pharmacol. 2012 May 1;83(9):1172-82. doi: 10.1016/j.bcp.2012.01.017. Epub 2012 Jan 21.
• [1136] Sulindac-derived reactive oxygen species induce apoptosis of human multiple myeloma cells via p38 mitogen activated protein kinase-induced mitochondrial dysfunction. Apoptosis. 2007 Jan;12(1):195-209. doi: 10.1007/s10495-006-0527-5.
• [1137] Inhibition of lung cancer cell growth by quercetin glucuronides via G2/M arrest and induction of apoptosis. Drug Metab Dispos. 2006 Feb;34(2):296-304. doi: 10.1124/dmd.105.005280. Epub 2005 Nov 9.
• [1138] Levamisole induced apoptosis in cultured vascular endothelial cells. Br J Pharmacol. 2000 Dec;131(8):1577-83.
• [1139] Non-steroidal anti-inflammatory drugs induce apoptosis in gastric cancer cells through up-regulation of bax and bak. Carcinogenesis. 2001 Sep;22(9):1393-7. doi: 10.1093/carcin/22.9.1393.
• [1140] AMPK activation induced by promethazine increases NOXA expression and Beclin-1 phosphorylation and drives autophagy-associated apoptosis in chronic myeloid leukemia. Chem Biol Interact. 2020 Jan 5;315:108888. doi: 10.1016/j.cbi.2019.108888. Epub 2019 Nov 2.
• [1141] Cannabidiol disrupts apoptosis, autophagy and invasion processes of placental trophoblasts. Arch Toxicol. 2021 Oct;95(10):3393-3406. doi: 10.1007/s00204-021-03122-z. Epub 2021 Jul 24.
• [1142] AMP-activated protein kinase activity is required for vanadate-induced hypoxia-inducible factor 1alpha expression in DU145 cells. Carcinogenesis. 2004 Dec;25(12):2497-507. doi: 10.1093/carcin/bgh253. Epub 2004 Aug 5.
• [1143] Identification of chemical compounds that induce HIF-1alpha activity. Toxicol Sci. 2009 Nov;112(1):153-63.
• [1144] NO-sulindac inhibits the hypoxia response of PC-3 prostate cancer cells via the Akt signalling pathway. Int J Cancer. 2009 Jan 1;124(1):223-32. doi: 10.1002/ijc.23934.
• [1145] Simvastatin stimulates vascular endothelial growth factor production by hypoxia-inducible factor-1alpha upregulation in endothelial cells. J Cardiovasc Pharmacol. 2008 Mar;51(3):267-73. doi: 10.1097/FJC.0b013e3181624b44.
• [1146] Epinephrine facilitates the growth of T cell lymphoma by altering cell proliferation, apoptosis, and glucose metabolism. Chem Biol Interact. 2023 Jan 5;369:110278. doi: 10.1016/j.cbi.2022.110278. Epub 2022 Nov 22.
• [1147] Screening autism-associated environmental factors in differentiating human neural progenitors with fractional factorial design-based transcriptomics. Sci Rep. 2023 Jun 29;13(1):10519. doi: 10.1038/s41598-023-37488-0.
• [1148] Gene expression profile induced by arsenic trioxide in chronic lymphocytic leukemia cells reveals a central role for heme oxygenase-1 in apoptosis and regulation of matrix metalloproteinase-9. Oncotarget. 2016 Dec 13;7(50):83359-83377.
• [1149] Effects of acute ethanol treatment on NCCIT cells and NCCIT cell-derived embryoid bodies (EBs). Toxicol In Vitro. 2010 Sep;24(6):1696-704. doi: 10.1016/j.tiv.2010.05.017. Epub 2010 May 26.
• [1150] Sulforaphane-induced apoptosis in human leukemia HL-60 cells through extrinsic and intrinsic signal pathways and altering associated genes expression assayed by cDNA microarray. Environ Toxicol. 2017 Jan;32(1):311-328.
• [1151] Targeting MYCN in neuroblastoma by BET bromodomain inhibition. Cancer Discov. 2013 Mar;3(3):308-23.
• [1152] Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. J Biol Chem. 2011 Feb 25;286(8):6602-13.
• [1153] A comparative transcriptomic study on the effects of valproic acid on two different hESCs lines in a neural teratogenicity test system. Toxicol Lett. 2014 Nov 18;231(1):38-44.
• [1154] Apoptosis, cell cycle progression and gene expression in TP53-depleted HCT116 colon cancer cells in response to short-term 5-fluorouracil treatment. Int J Oncol. 2007 Dec;31(6):1491-500.
• [1155] ON 01910.Na is selectively cytotoxic for chronic lymphocytic leukemia cells through a dual mechanism of action involving PI3K/AKT inhibition and induction of oxidative stress. Clin Cancer Res. 2012 Apr 1;18(7):1979-91. doi: 10.1158/1078-0432.CCR-11-2113. Epub 2012 Feb 20.
• [1156] Farnesol induces fatty acid oxidation and decreases triglyceride accumulation in steatotic HepaRG cells. Toxicol Appl Pharmacol. 2019 Feb 15;365:61-70.
• [1157] Differential effects of omega-3 and omega-6 Fatty acids on gene expression in breast cancer cells. Breast Cancer Res Treat. 2007 Jan;101(1):7-16. doi: 10.1007/s10549-006-9269-x. Epub 2006 Jul 6.
• [1158] The effect of DNA methylation inhibitor 5-Aza-2'-deoxycytidine on human endometrial stromal cells. Hum Reprod. 2010 Nov;25(11):2859-69.
• [1159] RNA sequence analysis of inducible pluripotent stem cell-derived cardiomyocytes reveals altered expression of DNA damage and cell cycle genes in response to doxorubicin. Toxicol Appl Pharmacol. 2018 Oct 1;356:44-53.
• [1160] Functional lipidomics: Palmitic acid impairs hepatocellular carcinoma development by modulating membrane fluidity and glucose metabolism. Hepatology. 2017 Aug;66(2):432-448. doi: 10.1002/hep.29033. Epub 2017 Jun 16.
• [1161] Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide. Br J Pharmacol. 2001 Oct;134(4):845-52. doi: 10.1038/sj.bjp.0704327.
• [1162] Comparison of protective effect of ascorbic acid on redox and endocannabinoid systems interactions in in vitro cultured human skin fibroblasts exposed to UV radiation and hydrogen peroxide. Arch Dermatol Res. 2017 May;309(4):285-303. doi: 10.1007/s00403-017-1729-0. Epub 2017 Mar 11.
• [1163] The anthelminthic drug praziquantel is a selective agonist of the sensory transient receptor potential melastatin type 8 channel. Toxicol Appl Pharmacol. 2017 Dec 1;336:55-65. doi: 10.1016/j.taap.2017.10.012. Epub 2017 Oct 18.
• [1164] Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures. Exp Dermatol. 2004 Mar;13(3):129-39. doi: 10.1111/j.0906-6705.2004.0178.x.
• [1165] The vanilloid receptor TRPV1 is activated and sensitized by local anesthetics in rodent sensory neurons. J Clin Invest. 2008 Feb;118(2):763-76. doi: 10.1172/JCI32751.
• [1166] Global changes in gene regulation demonstrate that unconjugated bilirubin is able to upregulate and activate select components of the endoplasmic reticulum stress response pathway. J Biochem Mol Toxicol. 2010 Mar-Apr;24(2):73-88.
• [1167] Genome-wide transcriptional and functional analysis of human T lymphocytes treated with benzo[alpha]pyrene. Int J Mol Sci. 2018 Nov 17;19(11).
• [1168] White-to-brown metabolic conversion of human adipocytes by JAK inhibition. Nat Cell Biol. 2015 Jan;17(1):57-67. doi: 10.1038/ncb3075. Epub 2014 Dec 8.
• [1169] Interindividual variation in gene expression responses and metabolite formation in acetaminophen-exposed primary human hepatocytes. Arch Toxicol. 2016 May;90(5):1103-15. doi: 10.1007/s00204-015-1545-2. Epub 2015 Jun 24.
• [1170] Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium. Mol Hum Reprod. 2007 Sep;13(9):641-54.
• [1171] Nitric oxide suppresses tumor cell migration through N-Myc downstream-regulated gene-1 (NDRG1) expression: role of chelatable iron. J Biol Chem. 2011 Dec 2;286(48):41413-41424. doi: 10.1074/jbc.M111.287052. Epub 2011 Oct 5.
• [1172] BET bromodomain inhibition as a novel strategy for reactivation of HIV-1. J Leukoc Biol. 2012 Dec;92(6):1147-54. doi: 10.1189/jlb.0312165. Epub 2012 Jul 16.
• [1173] A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies. PLoS Med. 2006 Dec;3(12):e486. doi: 10.1371/journal.pmed.0030486.
• [1174] Activation of peroxisome proliferator-activated receptor-gamma by troglitazone (TGZ) inhibits human lung cell growth. J Cell Biochem. 2005 Nov 1;96(4):760-74. doi: 10.1002/jcb.20474.
• [1175] Curcumin reduces the expression of survivin, leading to enhancement of arsenic trioxide-induced apoptosis in myelodysplastic syndrome and leukemia stem-like cells. Oncol Rep. 2016 Sep;36(3):1233-42. doi: 10.3892/or.2016.4944. Epub 2016 Jul 15.
• [1176] Effect of zoledronic acid on oral fibroblasts and epithelial cells: a potential mechanism of bisphosphonate-associated osteonecrosis. Br J Haematol. 2009 Mar;144(5):667-76. doi: 10.1111/j.1365-2141.2008.07504.x. Epub 2008 Nov 20.
• [1177] Niclosamide overcomes acquired resistance to erlotinib through suppression of STAT3 in non-small cell lung cancer. Mol Cancer Ther. 2013 Oct;12(10):2200-12. doi: 10.1158/1535-7163.MCT-13-0095. Epub 2013 Jul 26.
• [1178] Genome-wide local ancestry approach identifies genes and variants associated with chemotherapeutic susceptibility in African Americans. PLoS One. 2011;6(7):e21920. doi: 10.1371/journal.pone.0021920. Epub 2011 Jul 6.
• [1179] Flubendazole and mebendazole impair migration and epithelial to mesenchymal transition in oral cell lines. Chem Biol Interact. 2018 Sep 25;293:124-132. doi: 10.1016/j.cbi.2018.07.026. Epub 2018 Jul 31.
• [1180] Wnt signaling pathway is epigenetically regulated by methylation of Wnt antagonists in acute myeloid leukemia. Leukemia. 2009 Sep;23(9):1658-66. doi: 10.1038/leu.2009.86. Epub 2009 Apr 23.
• [1181] Epigenetic activation of O-linked -N-acetylglucosamine transferase overrides the differentiation blockage in acute leukemia. EBioMedicine. 2020 Apr;54:102678. doi: 10.1016/j.ebiom.2020.102678. Epub 2020 Apr 6.
• [1182] Selenium is critical for cancer-signaling gene expression but not cell proliferation in human colon Caco-2 cells. Biofactors. 2007;31(3-4):155-64. doi: 10.1002/biof.5520310302.
• [1183] Combined targeting of histone deacetylases and hedgehog signaling enhances cytoxicity in pancreatic cancer. Cancer Biol Ther. 2009 Jul;8(14):1328-39. doi: 10.4161/cbt.8.14.8633. Epub 2009 Jul 6.
• [1184] Differential regulation of proliferation, cell cycle control and gene expression in cultured human aortic and pulmonary artery endothelial cells by resveratrol. Int J Mol Med. 2010 Nov;26(5):743-9.
• [1185] Detection of the mechanism of immunotoxicity of cyclosporine A in murine in vitro and in vivo models. Arch Toxicol. 2015 Dec;89(12):2325-37. doi: 10.1007/s00204-014-1365-9. Epub 2014 Sep 17.
• [1186] Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors. Mol Cell. 2006 Nov 3;24(3):341-54. doi: 10.1016/j.molcel.2006.10.019.
• [1187] Hydrocortisone enhances the barrier properties of HBMEC/ci, a brain microvascular endothelial cell line, through mesenchymal-to-endothelial transition-like effects. Fluids Barriers CNS. 2015 Mar 5;12:7. doi: 10.1186/s12987-015-0003-0. eCollection 2015.
• [1188] Functional Profiling Identifies Determinants of Arsenic Trioxide Cellular Toxicity. Toxicol Sci. 2019 May 1;169(1):108-121. doi: 10.1093/toxsci/kfz024.
• [1189] Resveratrol modulates mRNA transcripts of genes related to redox metabolism and cell proliferation in non-small-cell lung carcinoma cells. Biol Chem. 2007 Feb;388(2):207-19.
• [1190] Activation of the p38 MAPK/Akt/ERK1/2 signal pathways is required for the protein stabilization of CDC6 and cyclin D1 in low-dose arsenite-induced cell proliferation. J Cell Biochem. 2010 Dec 15;111(6):1546-55. doi: 10.1002/jcb.22886.
• [1191] Caffeine disrupts ataxia telangiectasia mutated gene-related pathways and exacerbates acetaminophen toxicity in human fetal immortalized hepatocytes. Toxicology. 2021 Jun 15;457:152811. doi: 10.1016/j.tox.2021.152811. Epub 2021 May 7.
• [1192] Bisphenol-A impairs cellular function and alters DNA methylation of stress pathway genes in first trimester trophoblast cells. Reprod Toxicol. 2018 Dec;82:72-79.
• [1193] MCM-2 is a therapeutic target of Trichostatin A in colon cancer cells. Toxicol Lett. 2013 Jul 31;221(1):23-30. doi: 10.1016/j.toxlet.2013.05.643. Epub 2013 Jun 13.
• [1194] Taurine-responsive genes related to signal transduction as identified by cDNA microarray analyses of HepG2 cells. J Med Food. 2006 Spring;9(1):33-41. doi: 10.1089/jmf.2006.9.33.
• [1195] DNA double-strand breaks and Aurora B mislocalization induced by exposure of early mitotic cells to H(2)O(2) appear to increase chromatin bridges and resultant cytokinesis failure. Free Radic Biol Med. 2017 Jul;108:129-145. doi: 10.1016/j.freeradbiomed.2017.03.025. Epub 2017 Mar 24.
• [1196] Resveratrol-induced gene expression profiles in human prostate cancer cells. Cancer Epidemiol Biomarkers Prev. 2005 Mar;14(3):596-604. doi: 10.1158/1055-9965.EPI-04-0398.
• [1197] ATR inhibitors VE-821 and VX-970 sensitize cancer cells to topoisomerase i inhibitors by disabling DNA replication initiation and fork elongation responses. Cancer Res. 2014 Dec 1;74(23):6968-79.
• [1198] Extremely low copper concentrations affect gene expression profiles of human prostate epithelial cell lines. Chem Biol Interact. 2010 Oct 6;188(1):214-9.
• [1199] Berberine acts as a putative epigenetic modulator by affecting the histone code. Toxicol In Vitro. 2016 Oct;36:10-17. doi: 10.1016/j.tiv.2016.06.004. Epub 2016 Jun 13.
• [1200] Expression of NAG-1, a transforming growth factor-beta superfamily member, by troglitazone requires the early growth response gene EGR-1. J Biol Chem. 2004 Feb 20;279(8):6883-92. doi: 10.1074/jbc.M305295200. Epub 2003 Dec 8.
• [1201] Growth differentiation factor 15 production is necessary for normal erythroid differentiation and is increased in refractory anaemia with ring-sideroblasts. Br J Haematol. 2009 Jan;144(2):251-62. doi: 10.1111/j.1365-2141.2008.07441.x. Epub 2008 Nov 19.
• [1202] Exome-wide mutation profile in benzo[a]pyrene-derived post-stasis and immortal human mammary epithelial cells. Mutat Res Genet Toxicol Environ Mutagen. 2014 Dec;775-776:48-54. doi: 10.1016/j.mrgentox.2014.10.011. Epub 2014 Nov 4.
• [1203] Lymphocyte gene expression in subjects fed a low-choline diet differs between those who develop organ dysfunction and those who do not. Am J Clin Nutr. 2007 Jul;86(1):230-9. doi: 10.1093/ajcn/86.1.230.
• [1204] Toxicogenomics-based identification of mechanisms for direct immunotoxicity. Toxicol Sci. 2013 Oct;135(2):328-46.
• [1205] Differently expressed long noncoding RNAs and mRNAs in TK6 cells exposed to low dose hydroquinone. Oncotarget. 2017 Oct 4;8(56):95554-95567. doi: 10.18632/oncotarget.21481. eCollection 2017 Nov 10.
• [1206] Inter- and intra-laboratory study to determine the reproducibility of toxicogenomics datasets. Toxicology. 2011 Nov 28;290(1):50-8.
• [1207] Proteomics and disease network associations evaluation of environmentally relevant Bisphenol A concentrations in a human 3D neural stem cell model. Front Cell Dev Biol. 2023 Aug 16;11:1236243. doi: 10.3389/fcell.2023.1236243. eCollection 2023.
• [1208] The specific, submicromolar-Km ADP-ribose pyrophosphatase purified from human placenta is enzymically indistinguishable from recombinant NUDT9 protein, including a selectivity for Mn2+ as activating cation and increase in Km for ADP-ribose, both elicited by H2O2. Biochim Biophys Acta. 2006 Oct;1760(10):1545-51. doi: 10.1016/j.bbagen.2006.06.003. Epub 2006 Jun 9.
• [1209] Duvelisib treatment is associated with altered expression of apoptotic regulators that helps in sensitization of chronic lymphocytic leukemia cells to venetoclax (ABT-199). Leukemia. 2017 Sep;31(9):1872-1881. doi: 10.1038/leu.2016.382. Epub 2016 Dec 26.
• [1210] Silibinin inhibits ethanol- or acetaldehyde-induced ferroptosis in liver cell lines. Toxicol In Vitro. 2022 Aug;82:105388. doi: 10.1016/j.tiv.2022.105388. Epub 2022 May 18.
• [1211] Capsaicin inhibits the migration, invasion and EMT of renal cancer cells by inducing AMPK/mTOR-mediated autophagy. Chem Biol Interact. 2022 Oct 1;366:110043. doi: 10.1016/j.cbi.2022.110043. Epub 2022 Aug 28.
• [1212] PPAR- activation attenuates deltamethrin-induced apoptosis by regulating cytosolic PINK1 and inhibiting mitochondrial dysfunction. Toxicol Lett. 2016 Oct 17;260:8-17. doi: 10.1016/j.toxlet.2016.08.016. Epub 2016 Aug 21.
• [1213] Melatonin ameliorates acute lung injury caused by paraquat poisoning by promoting PINK1 and BNIP3 expression. Toxicology. 2023 May 15;490:153506. doi: 10.1016/j.tox.2023.153506. Epub 2023 Apr 5.
• [1214] Low Autophagy (ATG) Gene Expression Is Associated with an Immature AML Blast Cell Phenotype and Can Be Restored during AML Differentiation Therapy. Oxid Med Cell Longev. 2018 Mar 18;2018:1482795. doi: 10.1155/2018/1482795. eCollection 2018.
• [1215] Inhibitory effect of PXR on ammonia-induced hepatocyte autophagy via P53. Toxicol Lett. 2018 Oct 1;295:153-161. doi: 10.1016/j.toxlet.2018.06.1066. Epub 2018 Jun 14.
• [1216] TNF enhances trovafloxacin-induced in vitro hepatotoxicity by inhibiting protective autophagy. Toxicol Lett. 2021 May 15;342:73-84. doi: 10.1016/j.toxlet.2021.02.009. Epub 2021 Feb 17.
• [1217] The Bromodomain Inhibitor JQ1 and the Histone Deacetylase Inhibitor Panobinostat Synergistically Reduce N-Myc Expression and Induce Anticancer Effects. Clin Cancer Res. 2016 May 15;22(10):2534-44. doi: 10.1158/1078-0432.CCR-15-1666. Epub 2016 Jan 5.
• [1218] Cannabinoid derivatives induce cell death in pancreatic MIA PaCa-2 cells via a receptor-independent mechanism. FEBS Lett. 2006 Mar 20;580(7):1733-9.
• [1219] Effect of nephrotoxicants and hepatotoxicants on gene expression profile in human peripheral blood mononuclear cells. Biochem Biophys Res Commun. 2010 Oct 15;401(2):245-50. doi: 10.1016/j.bbrc.2010.09.039. Epub 2010 Sep 16.
• [1220] A high-throughput screen for teratogens using human pluripotent stem cells. Toxicol Sci. 2014 Jan;137(1):76-90. doi: 10.1093/toxsci/kft239. Epub 2013 Oct 23.
• [1221] Reduced camptothecin sensitivity of estrogen receptor-positive human breast cancer cells following exposure to di(2-ethylhexyl)phthalate (DEHP) is associated with DNA methylation changes. Environ Toxicol. 2019 Apr;34(4):401-414.
• [1222] Gene expression preferentially regulated by tamoxifen in breast cancer cells and correlations with clinical outcome. Cancer Res. 2006 Jul 15;66(14):7334-40.
• [1223] Arsenic trioxide exerts anti-lung cancer activity by inhibiting angiogenesis. Curr Cancer Drug Targets. 2014;14(6):557-66. doi: 10.2174/1568009614666140725090000.
• [1224] Propranolol inhibits proliferation and invasion of hemangioma-derived endothelial cells by suppressing the DLL4/Notch1/Akt pathway. Chem Biol Interact. 2018 Oct 1;294:28-33. doi: 10.1016/j.cbi.2018.08.018. Epub 2018 Aug 18.
• [1225] Role of delta-like ligand-4 in chemoresistance against docetaxel in MCF-7 cells. Hum Exp Toxicol. 2017 Apr;36(4):328-338. doi: 10.1177/0960327116650006. Epub 2016 Jun 22.
• [1226] Transcriptomic?pathway?and?benchmark dose analysis of Bisphenol A, Bisphenol S, Bisphenol F, and 3,3',5,5'-Tetrabromobisphenol A in H9 human embryonic stem cells. Toxicol In Vitro. 2021 Apr;72:105097. doi: 10.1016/j.tiv.2021.105097. Epub 2021 Jan 18.
• [1227] Molecular targeting of retinoic acid metabolism in neuroblastoma: the role of the CYP26 inhibitor R116010 in vitro and in vivo. Br J Cancer. 2007 Jun 4;96(11):1675-83.
• [1228] Estrogen receptor alpha (ER)-mediated coregulator binding and gene expression discriminates the toxic ER agonist diethylstilbestrol (DES) from the endogenous ER agonist 17-estradiol (E2). Cell Biol Toxicol. 2020 Oct;36(5):417-435. doi: 10.1007/s10565-020-09516-6. Epub 2020 Feb 22.
• [1229] Phenethyl isothiocyanate alters the gene expression and the levels of protein associated with cell cycle regulation in human glioblastoma GBM 8401 cells. Environ Toxicol. 2017 Jan;32(1):176-187.
• [1230] Endoplasmic reticulum stress contributes to autophagy and apoptosis in cantharidin-induced nephrotoxicity. Food Chem Toxicol. 2022 May;163:112986. doi: 10.1016/j.fct.2022.112986. Epub 2022 Apr 6.
• [1231] Artesunate alleviates liver fibrosis by regulating ferroptosis signaling pathway. Biomed Pharmacother. 2019 Jan;109:2043-2053. doi: 10.1016/j.biopha.2018.11.030. Epub 2018 Nov 26.
• [1232] Various concentrations of hesperetin induce different types of programmed cell death in human breast cancerous and normal cell lines in a ROS-dependent manner. Chem Biol Interact. 2023 Sep 1;382:110642. doi: 10.1016/j.cbi.2023.110642. Epub 2023 Jul 23.
• [1233] Sirtuin-3 (SIRT3), a novel potential therapeutic target for oral cancer. Cancer. 2011 Apr 15;117(8):1670-8. doi: 10.1002/cncr.25676. Epub 2010 Nov 29.
• [1234] Arsenic exposure, telomere length, and expression of telomere-related genes among Bangladeshi individuals. Environ Res. 2015 Jan;136:462-9. doi: 10.1016/j.envres.2014.09.040. Epub 2014 Nov 25.
• [1235] BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell. 2011 Sep 16;146(6):904-17.
• [1236] Bromodomain and extraterminal inhibition blocks tumor progression and promotes differentiation in?neuroblastoma. Surgery. 2015 Sep;158(3):819-26. doi: 10.1016/j.surg.2015.04.017. Epub 2015 Jun 9.
• [1237] Chronic senescent human mesenchymal stem cells as possible contributor to the wound healing disorder after exposure to the alkylating agent sulfur mustard. Arch Toxicol. 2021 Feb;95(2):727-747. doi: 10.1007/s00204-020-02946-5. Epub 2021 Jan 25.
• [1238] Daxx is a transcriptional repressor of CCAAT/enhancer-binding protein beta. J Biol Chem. 2009 Oct 16;284(42):28783-94. doi: 10.1074/jbc.M109.041186. Epub 2009 Aug 18.
• [1239] Synergistic effects of iron and aluminum on stress-related gene expression in primary human neural cells. J Alzheimers Dis. 2005 Nov;8(2):117-27; discussion 209-15. doi: 10.3233/jad-2005-8204.
• [1240] Synergistic effects of chemotherapeutic drugs in lymphoma cells are associated with down-regulation of inhibitor of apoptosis proteins (IAPs), prostate-apoptosis-response-gene 4 (Par-4), death-associated protein (Daxx) and with enforced caspase activation. Biochem Pharmacol. 2003 Sep 1;66(5):711-24. doi: 10.1016/s0006-2952(03)00410-6.
• [1241] Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors. J Med Chem. 2017 Feb 23;60(4):1262-1271. doi: 10.1021/acs.jmedchem.6b00990. Epub 2016 Dec 21.
• [1242] Effects of aromatase inhibitors on human osteoblast and osteoblast-like cells: a possible androgenic bone protective effects induced by exemestane. Bone. 2007 Apr;40(4):876-87. doi: 10.1016/j.bone.2006.11.029. Epub 2006 Dec 28.
• [1243] In vitro assessment of drug-induced liver steatosis based on human dermal stem cell-derived hepatic cells. Arch Toxicol. 2016 Mar;90(3):677-89. doi: 10.1007/s00204-015-1483-z. Epub 2015 Feb 26.
• [1244] Ethacrynic acid exhibits selective toxicity to chronic lymphocytic leukemia cells by inhibition of the Wnt/beta-catenin pathway. PLoS One. 2009 Dec 14;4(12):e8294. doi: 10.1371/journal.pone.0008294.
• [1245] Lovastatin protects human neurons against Abeta-induced toxicity and causes activation of beta-catenin-TCF/LEF signaling. Neurosci Lett. 2007 Feb 2;412(3):211-6. doi: 10.1016/j.neulet.2006.07.045. Epub 2007 Jan 17.
• [1246] Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer. Cancer Manag Res. 2009 Apr 3;1:25-37.
• [1247] Proteasome inhibition creates a chromatin landscape favorable to RNA Pol II processivity. J Biol Chem. 2020 Jan 31;295(5):1271-1287. doi: 10.1074/jbc.RA119.011174. Epub 2019 Dec 5.
• [1248] Prediction of the contact sensitizing potential of chemicals using analysis of gene expression changes in human THP-1 monocytes. Toxicol Lett. 2010 Nov 10;199(1):51-9.
• [1249] Effects of residual levels of tetracycline on the barrier functions of human intestinal epithelial cells. Food Chem Toxicol. 2017 Nov;109(Pt 1):253-263. doi: 10.1016/j.fct.2017.09.004. Epub 2017 Sep 4.
• [1250] Olesoxime prevents microtubule-targeting drug neurotoxicity: selective preservation of EB comets in differentiated neuronal cells. Biochem Pharmacol. 2010 Sep 15;80(6):884-94. doi: 10.1016/j.bcp.2010.04.018. Epub 2010 Apr 22.
• [1251] Antihypertrophic Effects of Small Molecules that Maintain Mitochondrial ATP Levels Under Hypoxia. EBioMedicine. 2017 Oct;24:147-158. doi: 10.1016/j.ebiom.2017.09.022. Epub 2017 Sep 19.
• [1252] Identification by functional cloning from a retroviral cDNA library of cDNAs for ribosomal protein L36 and the 10-kDa heat shock protein that confer cisplatin resistance. Mol Pharmacol. 2006 Apr;69(4):1383-8. doi: 10.1124/mol.105.017525. Epub 2006 Jan 4.
• [1253] Microarray analysis of bicalutamide action on telomerase activity, p53 pathway and viability of prostate carcinoma cell lines. J Pharm Pharmacol. 2005 Jan;57(1):83-92.
• [1254] DNA Methylome Analysis of Saturated Aliphatic Aldehydes in Pulmonary Toxicity. Sci Rep. 2018 Jul 12;8(1):10497. doi: 10.1038/s41598-018-28813-z.
• [1255] Dose- and time-dependent effects of phenobarbital on gene expression profiling in human hepatoma HepaRG cells. Toxicol Appl Pharmacol. 2009 Feb 1;234(3):345-60.
• [1256] LC, a novel estrone-rhein hybrid compound, promotes proliferation and differentiation and protects against cell death in human osteoblastic MG-63 cells. Mol Cell Endocrinol. 2011 Sep 15;344(1-2):59-68. doi: 10.1016/j.mce.2011.06.027. Epub 2011 Jul 13.