Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4F29C)

• Drug Name: Crizotinib Drug Info
• Synonyms: Xalkori (TN); novel ALK inhibitors

Indication

Disease Entry	ICD 11	Status	REF
Non-small-cell lung cancer	2C25.Y	Approved	[1]

• Cross-matching ID:
  PubChem CID: 11626560
  ChEBI ID: CHEBI:64310
  CAS Number: CAS 877399-52-5
  TTD Drug ID: DM4F29C
  VARIDT Drug ID: DR00523
  INTEDE Drug ID: DR0387
  ACDINA Drug ID: D00154

Molecule-Related Drug Atlas

Drug(s) Targeting Proto-oncogene c-Met (MET)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cabozantinib	DMIYDT4	Medullary thyroid gland carcinoma		Approved	[12]
Amivantamab	DMZ7AMY	Non-small-cell lung cancer	2C25	Approved	[13]
Capmatinib	DMYCXKL	Non-small-cell lung cancer	2C25.Y	Approved	[14]
Tepotinib	DMUQ0E8	Non-small-cell lung cancer	2C25	Approved	[15]
RG3638	DMTQJE0	Gastric adenocarcinoma	2B72	Phase 3	[16]
Savolitinib	DMALFKX	Renal cell carcinoma	2C90	Phase 3	[17]
Beperminogene perplasmid	DM6RWBN	Critical limb ischemia	BD4Y	Phase 3	[18]
Tivantinib	DMNVP8Q	Hepatocellular carcinoma	2C12.02	Phase 3	[19]
MGCD516	DM752PU	Solid tumour/cancer	2A00-2F9Z	Phase 2/3	[16]
CMX-2043	DMPSCVY	Cardiac disease	BA00-BE2Z	Phase 2	[20]

Drug(s) Targeting ALK tyrosine kinase receptor (ALK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lorlatinib	DMICDLV	Non-small-cell lung cancer	2C25.Y	Approved	[21]
Entrectinib	DMMPTLH	Non-small-cell lung cancer	2C25	Approved	[22]
Brigatinib	DM7W94S	Anaplastic large cell lymphoma	2A90.A	Approved	[23]
Repotrectinib	DM9FB2T	Non-small-cell lung cancer	2C25	Approved	[17]
Ceritinib	DMB920Z	Non-small-cell lung cancer	2C25.Y	Approved	[24]
Alectinib	DMP1I6Y	Lung cancer	2C25.0	Approved	[25]
Ensartinib	DMIKDCQ	Non-small-cell lung cancer	2C25.Y	Phase 3	[17]
PF-06463922	DMKM7EW	Non-small-cell lung cancer	2C25.Y	Phase 2	[26]
AP26113	DMYBQEF	Solid tumour/cancer	2A00-2F9Z	Phase 2	[27]
TSR-011	DMFOR9Y	Non-small-cell lung cancer	2C25.Y	Phase 1/2	[28]
Ceritinib	DMB920Z	Non-small-cell lung cancer	2C25.Y	Approved	[94]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Masoprocol	DMMVNZ0	Prostate cancer	2C82.0	Approved	[95]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[97]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[98]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[100]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[101]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[102]

Drug(s) Targeting Proto-oncogene c-Ros (ROS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lorlatinib	DMICDLV	Non-small-cell lung cancer	2C25.Y	Approved	[21]
Entrectinib	DMMPTLH	Non-small-cell lung cancer	2C25	Approved	[22]
Repotrectinib	DM9FB2T	Non-small-cell lung cancer	2C25	Approved	[17]
AB-106	DMEW62S	Non-small-cell lung cancer	2C25	Phase 2	[29]
DS-6051	DM0RD4F	Solid tumour/cancer	2A00-2F9Z	Phase 1	[30]
Carboxamide derivative 4	DMU5GKC	N. A.	N. A.	Patented	[31]
Imidazo[1,2-b]pyridazine derivative 2	DM1JYNW	Solid tumour/cancer	2A00-2F9Z	Patented	[32]
Imidazo[1,2-b]pyridazine derivative 3	DMPDTG0	Solid tumour/cancer	2A00-2F9Z	Patented	[32]
PMID28270010-Compound-Figure21-b	DM6IYAT	Brain metastases	2D50	Patented	[32]
Imidazo[1,2-b]pyridazine derivative 1	DMULTAI	Solid tumour/cancer	2A00-2F9Z	Patented	[32]

Drug(s) Targeting HGF/Met signaling pathway (HGF/Met pathway)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fosgonimeton	DMXMAJA	Alzheimer disease	8A20	Phase 2/3	[33]
SAIT301	DMLU6J0	Nasopharyngeal carcinoma	2B6B	Investigative	[34]

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[35]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[36]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[37]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[38]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[37]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[37]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[39]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[37]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[40]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[41]

Drug(s) Transported By Organic anion transporting polypeptide 1B1 (SLCO1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[42]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[43]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[4]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[44]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[4]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[45]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[46]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[47]
Cerivastatin	DMXCM7H	Hyperlipidaemia	5C80	Approved	[48]
PITAVASTATIN CALCIUM	DM1UJO0	Dyslipidemia	5C80-5C81	Approved	[45]

Drug(s) Transported By Organic anion transporting polypeptide 1B3 (SLCO1B3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[49]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[4]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[50]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[51]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[4]
Pravastatin	DM6A0X7	Adult acute monocytic leukemia		Approved	[52]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[46]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[48]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[53]
Cerivastatin	DMXCM7H	Hyperlipidaemia	5C80	Approved	[48]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[54]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[55]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[56]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[57]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[58]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[59]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[60]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[61]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[55]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[62]
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[72]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[73]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[74]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[75]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[76]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[76]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[77]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[78]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[79]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[80]

Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[63]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[64]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[65]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[68]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[69]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[70]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[71]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[66]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[81]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[82]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[83]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[84]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[85]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[86]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[87]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[88]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[86]
Levetiracetam	DMTGDN8	Epilepsy	8A60-8A68	Approved	[83]

Drug(s) Affected By Hepatocyte growth factor receptor (MET)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cabozantinib	DMIYDT4	Medullary thyroid gland carcinoma		Approved	[89]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[90]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[90]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[90]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[91]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[93]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[91]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[90]

Drug(s) Affected By Prominin-1 (PROM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[103]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[104]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[107]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[108]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[109]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[110]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[111]

Drug(s) Affected By CD44 antigen (CD44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[112]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[113]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[114]
Selenium	DM25CGV	N. A.	N. A.	Approved	[115]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[103]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[117]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[118]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[120]

Drug(s) Affected By Epithelial cell adhesion molecule (EPCAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[118]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[122]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[124]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[125]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[111]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[126]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[127]

Drug(s) Affected By Cytidine deaminase (CDA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[128]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[129]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[114]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[130]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[131]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[133]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[134]

Drug(s) Affected By Insulin-induced gene 1 protein (INSIG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[135]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[136]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[138]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[130]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[138]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[139]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[140]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[141]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[140]

Drug(s) Affected By Acyl-CoA 6-desaturase (FADS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[136]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[142]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[130]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[134]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[143]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[108]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[144]
Bortezomib	DMNO38U	Leukemia		Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[146]

Drug(s) Affected By 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[147]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[148]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[149]
Digoxin	DMQCTIH	Arrhythmia	BC9Z	Approved	[150]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[151]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[152]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[136]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[153]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[154]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[155]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[156]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[157]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[158]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[159]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[160]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[161]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[162]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[163]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[164]

Drug(s) Affected By Fatty acid synthase (FASN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[165]
Selenium	DM25CGV	N. A.	N. A.	Approved	[166]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[152]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[167]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[168]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[169]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[153]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[170]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[171]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[172]

Drug(s) Affected By Caspase-7 (CASP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[173]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[174]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[175]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[176]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[177]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[177]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[178]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[179]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[180]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[181]

Drug(s) Affected By Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[182]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[183]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[114]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[184]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[184]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[169]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[184]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[153]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[117]

Drug(s) Affected By Sterol regulatory element-binding protein 2 (SREBF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[150]
Selenium	DM25CGV	N. A.	N. A.	Approved	[166]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[185]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[153]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[186]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[187]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[188]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[168]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[133]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[168]

Drug(s) Affected By Potassium voltage-gated channel subfamily H member 2 (KCNH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metoclopramide	DMFA5MY	Nausea	MD90	Approved	[189]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[190]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[191]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[192]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[192]
Disopyramide	DM5SYZP	Long QT syndrome	BC65.0	Approved	[193]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[194]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[195]
Dofetilide	DMPN1TW	Sinus rhythm disorder	BC9Y	Approved	[196]
Flecainide	DMSQDLE	Tachyarrhythmias	BC71	Approved	[192]

Drug(s) Affected By Acetyl-CoA carboxylase 1 (ACACA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[197]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[198]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[167]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[199]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[153]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[186]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[172]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[130]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[200]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[201]

Drug(s) Affected By Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[183]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Retigabine	DMGNYIH	Behcet disease	4A62	Approved	[204]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[205]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[206]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[207]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[208]

Drug(s) Affected By Sodium channel protein type 5 subunit alpha (SCN5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Disopyramide	DM5SYZP	Long QT syndrome	BC65.0	Approved	[150]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[209]
Flecainide	DMSQDLE	Tachyarrhythmias	BC71	Approved	[210]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[211]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[212]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[213]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[203]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[214]
Retigabine	DMGNYIH	Behcet disease	4A62	Approved	[204]
Luvox	DMJKROX	Anxiety disorder	6B00-6B0Z	Approved	[215]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[216]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[217]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[218]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[219]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[220]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[221]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[222]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[223]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[224]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[225]

Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[226]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[227]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[228]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[229]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[118]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[230]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[231]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[131]
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[232]

Drug(s) Affected By Follitropin subunit beta (FSHB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[233]
Goserelin	DMAT8CG	Breast cancer	2C60-2C65	Approved	[234]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[235]
Cetrorelix	DMFD9Q6	Ovarian stimulation	LB45.1	Approved	[236]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[237]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[238]
Risperidone	DMN6DXL	Bipolar I disorder		Approved	[239]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[240]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[111]
Naltrexone	DMUL45H	Alcohol dependence	6C40.2	Approved	[241]

Drug(s) Affected By Lutropin subunit beta (LHB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[242]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[243]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[244]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[245]
Alprazolam	DMC7XDN	Anxiety		Approved	[246]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Norethindrone acetate	DMDGCQP	N. A.	N. A.	Approved	[243]
Metoclopramide	DMFA5MY	Nausea	MD90	Approved	[245]
Cetrorelix	DMFD9Q6	Ovarian stimulation	LB45.1	Approved	[236]
Ganirelix	DMGMB30	Ovulation dysfunction	5A80	Approved	[247]

Drug(s) Affected By Tyrosine-protein kinase Lck (LCK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[183]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[117]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[130]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[139]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[248]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[249]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[250]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[251]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[252]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[253]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[254]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[255]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[219]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[256]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[257]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[256]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[258]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[259]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[260]

Drug(s) Affected By Tissue factor (F3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[261]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[262]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[263]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[264]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[265]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[266]
Fructose	DM43AN2	Vomiting	MD90	Approved	[267]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[268]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[269]
Desloratadine	DM56YN7	Allergic rhinitis	CA08.0	Approved	[262]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[270]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[271]
Selenium	DM25CGV	N. A.	N. A.	Approved	[166]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[272]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[273]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[274]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[104]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[275]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[181]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[276]

Drug(s) Affected By Alanine aminotransferase 1 (GPT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[150]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[277]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[278]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[150]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[150]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[150]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[8]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[279]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[8]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[280]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[281]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[282]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[283]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[284]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[285]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[286]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[287]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[288]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[289]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[290]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[291]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[282]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[292]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[293]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[294]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[281]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[150]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[112]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[284]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[285]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[295]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[296]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[297]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[298]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[299]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[300]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[301]
Selenium	DM25CGV	N. A.	N. A.	Approved	[166]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[152]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[302]

Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[150]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[112]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[303]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[304]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[305]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[306]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[307]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[308]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[309]

Drug(s) Affected By Ras GTPase-activating-like protein IQGAP1 (IQGAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[310]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[213]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[118]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[311]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[312]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[123]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[143]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[235]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[124]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[313]

Drug(s) Affected By Small ribosomal subunit protein eS6 (RPS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[314]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[315]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[316]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[317]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[318]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[319]
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[295]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[311]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[312]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 2 (BIRC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[320]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[164]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[321]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[322]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[323]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[324]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[325]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[326]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[311]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[327]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[328]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[329]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[112]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[330]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[331]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[219]
Selenium	DM25CGV	N. A.	N. A.	Approved	[166]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[332]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[333]

Drug(s) Affected By Echinoderm microtubule-associated protein-like 4 (EML4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[198]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[316]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[311]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[134]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[143]
Mecamylamine	DMGQFYB	Essential hypertension	BA00	Approved	[334]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[335]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[145]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[111]

Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[336]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[336]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[337]
Sunitinib	DMCBJSR	Acute undifferentiated leukemia		Approved	[150]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[338]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[103]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[339]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[340]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[341]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[342]

Drug(s) Affected By GTPase KRas (KRAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[343]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[344]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[130]
Tiazofurin	DM5JWV9	Solid tumour/cancer	2A00-2F9Z	Approved	[345]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[346]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[347]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[348]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[349]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[350]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[351]

Drug(s) Affected By Pro-epidermal growth factor (EGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[352]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[353]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[354]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[355]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[118]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[356]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[357]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[131]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[311]

Drug(s) Affected By Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[358]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[359]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[360]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[361]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[362]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[363]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[174]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[198]
Selenium	DM25CGV	N. A.	N. A.	Approved	[364]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[365]

Drug(s) Affected By Mast/stem cell growth factor receptor Kit (KIT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[366]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[367]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[183]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[186]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[118]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[368]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[369]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[370]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[371]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[108]

Drug(s) Affected By Proheparin-binding EGF-like growth factor (HBEGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[372]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[373]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[374]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[92]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[171]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[171]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[375]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[376]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[187]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[140]

Drug(s) Affected By Protransforming growth factor alpha (TGFA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[377]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[377]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[202]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[170]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[378]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[379]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[132]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[380]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[134]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[124]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
ALK tyrosine kinase receptor (ALK)	TTPMQSO	ALK_HUMAN	Modulator	[2]
HGF/Met signaling pathway (HGF/Met pathway)	TTKA5LP	NOUNIPROTAC	Inhibitor	[3]
Proto-oncogene c-Met (MET)	TTNDSF4	MET_HUMAN	Modulator	[2]
Proto-oncogene c-Ros (ROS1)	TTSZ6Y3	ROS1_HUMAN	Modulator	[2]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Organic anion transporting polypeptide 1B1 (SLCO1B1)	DT3D8F0	SO1B1_HUMAN	Substrate	[4]
Organic anion transporting polypeptide 1B3 (SLCO1B3)	DT9C1TS	SO1B3_HUMAN	Substrate	[4]
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[5]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4) Main DME	DE4LYSA	CP3A4_HUMAN	Substrate	[6]
Cytochrome P450 3A5 (CYP3A5) Main DME	DEIBDNY	CP3A5_HUMAN	Substrate	[6]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)	OTRT3F3U	HMDH_HUMAN	Gene/Protein Processing	[7]
Acetyl-CoA carboxylase 1 (ACACA)	OT5CQPZY	ACACA_HUMAN	Post-Translational Modifications	[7]
Acyl-CoA 6-desaturase (FADS2)	OTUX531P	FADS2_HUMAN	Gene/Protein Processing	[7]
Alanine aminotransferase 1 (GPT)	OTOXOA0Q	ALAT1_HUMAN	Protein Interaction/Cellular Processes	[8]
ALK tyrosine kinase receptor (ALK)	OTV3P4V8	ALK_HUMAN	Drug Response	[9]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Gene/Protein Processing	[10]
Baculoviral IAP repeat-containing protein 2 (BIRC2)	OTFXFREP	BIRC2_HUMAN	Gene/Protein Processing	[11]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Gene/Protein Processing	[11]
Bcl-2-like protein 11 (BCL2L11)	OTNQQWFJ	B2L11_HUMAN	Gene/Protein Processing	[11]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)	OTW8V2V1	ABCG2_HUMAN	Gene/Protein Processing	[10]

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