Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMN3UXQ)

• Drug Name: Diethylstilbestrol Drug Info
• Synonyms: Acnestrol; Agostilben; Antigestil; Apstil; Bufon; Climaterine; Comestrol; Cyren; DES; Desma; Destrol; Diaethylstilboestrolum; Diastyl; Dibestrol; Dicorvin; Diethylstilbesterol; Diethylstilbestrolum; Diethylstilboesterol; Dietilestilbestrol; Dietilstilbestrolo; Distilbene; Domestrol; Dyestrol; Estril; Estrobene; Estrogenine; Estromenin; Estrosyn; Fonatol; Grafestrol; Gynopharm; Hibestrol; Idroestril; Iscovesco; Makarol; Menostilbeen; Micrest; Microest; Milestrol; OeKolp; Oestrogenine; Oestrolmensil; Oestromenin; Oestromensil; Oestromensyl; Oestromienin; Oestromon; Pabestrol; Palestrol; Protectona; Sedestran; Serral; Sexocretin; Sibol; Sintestrol; Stibilium; Stilbestroform; Stilbestrol; Stilbestrone; Stilbetin; Stilboefral; Stilboestroform; Stilboestrol; Stilbofolin; Stilbofollin; Stilbol; Stilkap; Strobene; Synestrin; Synthestrin; Synthoestrin; Synthofolin; Syntofolin; Tampovagan; Tylosterone; Vagestrol; APS Brand of Diethylstilbestrol; Anti gestil; Co Pharma Brand of Diethylstilbestrol; Comestrol estrobene; Cyren A; Diethylstilbestrol BP; Dietilestilbestrol [Spanish]; Dietilstilbestrolo [DCIT]; Estilbin MCO; Gerda Brand of Diethylstilbestrol; Oestrol vetag; Percutatrine oestrogenique iscovesco; ST IL; Stilbene Estrogen; Tampovagan stilboestrol; DiBestrol 2 Premix; MG 137; Rumestrol 1; Rumestrol 2; Cis-Des; Cis-Diethylstilbesterol; Cis-Diethylstilbestrol; Co-Pharma Brand of Diethylstilbestrol; DES (synthetic estrogen); Dawe's destrol; Di-Estryl; Diethylstilbestrol (DES); Diethylstilbestrol [USAN:INN]; Diethylstilbestrol, Disodium Salt; Diethylstilbestrolum [INN-Latin]; Dietilestilbestrol [INN-Spanish]; E-Diethylstilbestrol; Estilbin (MCO); Estrogen, Stilbene; Hi-Bestrol; Neo-Oestranol 1; Neo-Oestranol I; Neo-oe stranol 1; New-Estranol 1; Stil-Rol; Stilbestrol (TN); TRANS-DIETHYSTILBESTEROL; TRANSGENIC MODEL EVALUATION (DES); Trans-Diethylstilbesterol; Trans-Diethylstilbestrol; Trans-Diethylstilboesterol; DiBestrol "2" Premix; Dibestrol '2' premix; Diethylstilbestrol (USP/INN); Alpha,alpha'-Diethylstilbenediol; Diethylstilbestrol, (Z)-Isomer; Alpha,alpha'-Diethyl-4,4'-stilbenediol; (E)-3,4-Bis(4-hydroxyphenyl)-3-hexene; (E)-4,4'-(hex-3-ene-3,4-diyl)diphenol; (E)-Diethylstilbestrol; 3,4'(4,4'-Dihydroxyphenyl)hex-3-ene; 3,4-Bis(p-hydroxyphenyl)-3-hexene; 3,4-bis(4-hydroxyphenyl)hex-3-ene; 4,4'-(3E)-hex-3-ene-3,4-diyldiphenol; 4,4'-Dihydroxydiethylstilbene; 4,4'-hex-3-ene-3,4-diyldiphenol

Indication

Disease Entry	ICD 11	Status	REF
Gonorrheal vaginitis	GA02	Approved	[1]

• Therapeutic Class: Anticancer Agents
• Cross-matching ID:
  PubChem CID: 448537
  ChEBI ID: CHEBI:41922
  CAS Number: CAS 56-53-1
  TTD Drug ID: DMN3UXQ
  VARIDT Drug ID: DR00922
  INTEDE Drug ID: DR0492

Molecule-Related Drug Atlas

Drug(s) Targeting Estrogen receptor (ESR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[10]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[11]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[11]
Estradiol Valerate	DM8MC6O	Hormone replacement therapy	8E01	Approved	[12]
Estradiol Acetate	DM07U2A	Hormone replacement therapy	8E01	Approved	[12]
Estradiol Cypionate	DM27Z5T	Hormone replacement therapy	8E01	Approved	[12]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[13]
Raloxifene	DMDKF3M	Osteoporosis	FB83.0	Approved	[14]
Ospemifene	DMC4GEI	Dyspareunia	GA12	Approved	[15]
Toremifene	DMQYUWG	Breast cancer	2C60-2C65	Approved	[16]

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[17]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[18]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[19]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[20]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[19]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[19]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[21]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[19]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[3]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[22]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[23]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[24]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[25]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[26]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[27]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[28]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[29]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[30]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[24]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[31]
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[40]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[41]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[42]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[43]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[45]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[46]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[47]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[48]

Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[32]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[33]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[34]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[35]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[36]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[37]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[33]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[38]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[39]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[49]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[50]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[51]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[52]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[53]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[54]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[55]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[56]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[57]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[55]

Drug(s) Affected By Alpha-1-antichymotrypsin (SERPINA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[58]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[60]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[58]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[58]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[61]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[62]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[58]

Drug(s) Affected By Trefoil factor 1 (TFF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[63]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[65]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[66]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[67]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[65]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[69]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[71]

Drug(s) Affected By Transforming growth factor beta-3 proprotein (TGFB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[72]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[73]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[76]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]

Drug(s) Affected By Amine oxidase A (MAOA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[84]
Selegiline	DM6034S	Major depressive disorder	6A70.3	Approved	[85]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]

Drug(s) Affected By Glutathione S-transferase Mu 3 (GSTM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[90]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[99]

Drug(s) Affected By Cbp/p300-interacting transactivator 2 (CITED2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[73]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[101]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]

Drug(s) Affected By Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) (SLC6A14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[81]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[106]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[105]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[87]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[109]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]

Drug(s) Affected By Cholesterol side-chain cleavage enzyme, mitochondrial (CYP11A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[112]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[113]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[115]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[116]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[117]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[118]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]

Drug(s) Affected By 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[120]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[121]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[123]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[124]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[125]
Hexachlorophene	DMLKSE0	Bacterial infection	1A00-1C4Z	Approved	[126]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[64]

Drug(s) Affected By 17-beta-hydroxysteroid dehydrogenase type 1 (HSD17B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[127]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Metyrapone	DMI7FVQ	Cushing disease	5A70	Approved	[128]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[129]
Dutasteride	DMQ4TJK	Benign prostatic hyperplasia	GA90	Approved	[130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[131]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[9]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[132]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[127]

Drug(s) Affected By Homeobox protein DLX-4 (DLX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[133]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[135]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[137]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[139]

Drug(s) Affected By 5-hydroxymethyl-dUMP N-hydrolase (DNPH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[141]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[142]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[143]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[144]

Drug(s) Affected By Programmed cell death protein 6 (PDCD6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[145]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[146]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[147]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[148]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[120]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[149]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[150]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[151]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[152]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[86]
Selenium	DM25CGV	N. A.	N. A.	Approved	[153]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[154]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[155]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[156]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[157]

Drug(s) Affected By Apolipoprotein E (APOE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[158]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[159]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[74]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]

Drug(s) Affected By Calpain small subunit 1 (CAPNS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[140]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[163]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[164]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[160]

Drug(s) Affected By Prothymosin alpha (PTMA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[167]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[168]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[145]
Haloperidol	DM96SE0	Delirium		Approved	[169]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[141]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[169]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]

Drug(s) Affected By Tyrosine-protein kinase Lyn (LYN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[120]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[121]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[163]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[171]

Drug(s) Affected By Tyrosine-protein kinase Fgr (FGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[86]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[163]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[145]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[173]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[174]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[139]

Drug(s) Affected By DNA polymerase alpha catalytic subunit (POLA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[176]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[178]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[179]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[180]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[106]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[181]

Drug(s) Affected By Clusterin (CLU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[182]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[182]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[61]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Levamisole	DM5EN79	Parasitic infection	1D0Y-1G2Z	Approved	[183]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[182]

Drug(s) Affected By Ski oncogene (SKI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[184]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[186]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]

Drug(s) Affected By Glucosidase 2 subunit beta (PRKCSH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[188]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[189]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[190]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[191]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[191]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[192]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[193]

Drug(s) Affected By Fos-related antigen 1 (FOSL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[194]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[195]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[178]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[196]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[197]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[198]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[76]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]

Drug(s) Affected By Nucleoside diphosphate kinase A (NME1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[199]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[201]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[202]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[203]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[204]

Drug(s) Affected By Insulin-like growth factor-binding protein 2 (IGFBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[194]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[205]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[206]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[208]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]

Drug(s) Affected By Nucleoside diphosphate kinase B (NME2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[209]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[210]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[211]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[212]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[209]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[181]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[213]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[214]

Drug(s) Affected By Stromelysin-3 (MMP11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[140]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[215]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[125]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[216]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[139]

Drug(s) Affected By Integrin beta-7 (ITGB7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[86]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[172]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[217]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[218]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[179]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[219]
STO609	DMZSOG2	Discovery agent	N.A.	Investigative	[220]

Drug(s) Affected By Adenosine receptor A1 (ADORA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[73]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[184]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[140]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[221]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[222]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]

Drug(s) Affected By Cyclin-dependent kinases regulatory subunit 2 (CKS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[178]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[76]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[141]

Drug(s) Affected By Replication protein A 14 kDa subunit (RPA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[176]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[223]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[224]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[225]
Bortezomib	DMNO38U	Leukemia		Approved	[226]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[227]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[228]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[150]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[229]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[230]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[231]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[232]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[233]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[234]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]

Drug(s) Affected By Small ribosomal subunit protein eS19 (RPS19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[235]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[236]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[237]
Bortezomib	DMNO38U	Leukemia		Approved	[238]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[188]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]

Drug(s) Affected By DNA mismatch repair protein Mlh1 (MLH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[184]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[240]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[241]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[242]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[243]

Drug(s) Affected By Replication factor C subunit 5 (RFC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[176]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[244]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[245]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[169]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[180]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[246]

Drug(s) Affected By Signal transducer and activator of transcription 1-alpha/beta (STAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[247]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[248]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[249]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[250]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[251]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[252]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[253]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[249]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[254]

Drug(s) Affected By Netrin receptor DCC (DCC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[255]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[256]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[100]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[100]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
Taxifolin	DMQJSF9	N. A.	N. A.	Preclinical	[257]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[120]

Drug(s) Affected By Rap1 GTPase-activating protein 1 (RAP1GAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[205]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[258]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[171]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[259]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[260]

Drug(s) Affected By Fms-related tyrosine kinase 3 ligand (FLT3LG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[261]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[217]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[262]
Rutin	DMEHRAJ	Discovery agent	N.A.	Investigative	[263]
CATECHIN	DMY38SB	Discovery agent	N.A.	Investigative	[263]

Drug(s) Affected By Adenosine 5'-monophosphoramidase HINT1 (HINT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[140]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[179]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[265]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[266]
EXISULIND	DMBY56U	Colorectal cancer	2B91.Z	Phase 3	[267]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[268]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1C (CDKN1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[244]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[269]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[62]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[270]

Drug(s) Affected By Protein Tob1 (TOB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[120]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[271]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[270]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[272]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]

Drug(s) Affected By Tyrosine-protein kinase JAK3 (JAK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[157]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[273]
Ceritinib	DMB920Z	Non-small-cell lung cancer	2C25.Y	Approved	[274]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[270]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[125]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[273]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[275]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]

Drug(s) Affected By Cyclin-dependent kinases regulatory subunit 1 (CKS1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[276]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[277]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[180]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[181]

Drug(s) Affected By Small ribosomal subunit protein eS1 (RPS3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[147]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[278]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[279]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[280]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[281]

Drug(s) Affected By Cyclin-dependent kinase 5 (CDK5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[282]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[283]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[284]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[121]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[178]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]

Drug(s) Affected By Dual specificity mitogen-activated protein kinase kinase 1 (MAP2K1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[285]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[286]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[287]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[288]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[289]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[290]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[147]

Drug(s) Affected By Activated CDC42 kinase 1 (TNK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[139]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[291]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[293]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[120]
Rutin	DMEHRAJ	Discovery agent	N.A.	Investigative	[263]

Drug(s) Affected By Epithelial discoidin domain-containing receptor 1 (DDR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[171]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[125]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[294]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[295]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[294]

Drug(s) Affected By Adenylate cyclase type 1 (ADCY1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[296]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[173]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[173]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[222]

Drug(s) Affected By Cell division cycle protein 20 homolog (CDC20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[176]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[199]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[140]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[234]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[297]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]

Drug(s) Affected By TNF receptor-associated factor 3 (TRAF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[223]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[147]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[298]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[299]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Hydroxychloroquine	DMSIVND	Chronic renal failure	GB61.Z	Approved	[300]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]

Drug(s) Affected By Frizzled-2 (FZD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[301]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[198]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[302]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]

Drug(s) Affected By Cyclin-dependent kinase 10 (CDK10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[120]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[140]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[303]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[304]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[305]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]

Drug(s) Affected By Sulfotransferase 1E1 (SULT1E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[306]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[306]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[307]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[308]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[306]
Dienestrol	DMBSXI0	Atrophic vaginitis	GA30.2	Approved	[308]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[309]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[310]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[124]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[311]

Drug(s) Affected By Aromatase (CYP19A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[312]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[313]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[314]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[73]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[314]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[157]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[315]
Bifonazole	DM3KN7V	Fungal infection	1F29-1F2F	Approved	[316]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[317]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[314]

Drug(s) Affected By Espin (ESPN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[310]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[205]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[186]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[87]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[318]

Drug(s) Affected By Atypical chemokine receptor 2 (ACKR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[186]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[319]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[7]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[320]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[120]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[321]

Drug(s) Affected By Calpain-9 (CAPN9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[147]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[139]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[7]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[122]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[7]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[7]

Drug(s) Affected By ATP-binding cassette sub-family C member 3 (ABCC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[322]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[323]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[324]
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[325]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[326]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[151]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[327]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[328]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[329]

Drug(s) Affected By E3 ubiquitin-protein ligase SIAH2 (SIAH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[330]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[330]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[163]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[173]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]

Drug(s) Affected By Proline dehydrogenase 1, mitochondrial (PRODH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[205]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[331]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[205]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[147]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[332]

Drug(s) Affected By Band 4.1-like protein 2 (EPB41L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[86]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[106]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[333]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[334]

Drug(s) Affected By Galanin receptor type 2 (GALR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[335]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[7]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[336]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[7]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[321]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[179]

Drug(s) Affected By Regulator of G-protein signaling 10 (RGS10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[125]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[337]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[338]

Drug(s) Affected By Protein CBFA2T3 (CBFA2T3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[222]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[7]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[339]

Drug(s) Affected By Cartilage intermediate layer protein 1 (CILP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[340]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[222]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[341]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[7]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[222]

Drug(s) Affected By Short-chain dehydrogenase/reductase 3 (DHRS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[342]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[343]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[258]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[171]

Drug(s) Affected By RasGAP-activating-like protein 1 (RASAL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[171]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[344]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[318]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[179]

Drug(s) Affected By EGF-containing fibulin-like extracellular matrix protein 2 (EFEMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[121]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[141]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[311]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[337]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[337]

Drug(s) Affected By Actin-associated protein FAM107A (FAM107A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[171]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[337]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[337]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[222]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[345]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[100]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[239]

Drug(s) Affected By Carbonic anhydrase 2 (CA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetazolamide	DM1AF5U	Absence epilepsy		Approved	[346]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[347]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[348]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[84]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[349]
Topiramate	DM82Z30	Alcohol dependence	6C40.2	Approved	[350]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[343]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[351]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]

Drug(s) Affected By Protransforming growth factor alpha (TGFA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[73]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[73]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[352]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[353]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[343]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[354]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[355]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[356]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[357]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[358]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[90]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[359]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[360]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[361]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[362]

Drug(s) Affected By Thrombospondin-1 (THBS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[73]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[194]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[157]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[244]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[363]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[249]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[62]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[163]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]

Drug(s) Affected By Beta-microseminoprotein (MSMB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[121]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[310]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[118]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[364]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[365]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[64]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[366]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[364]

Drug(s) Affected By Amino acid transporter heavy chain SLC3A2 (SLC3A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[271]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[367]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[368]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[369]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[368]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[173]

Drug(s) Affected By Hepatocyte growth factor receptor (MET)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cabozantinib	DMIYDT4	Medullary thyroid gland carcinoma		Approved	[370]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[371]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[372]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[372]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[372]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[249]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[372]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[373]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[249]

Drug(s) Affected By Retinol-binding protein 1 (RBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[374]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[375]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[258]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[333]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[376]

Drug(s) Affected By Alkaline phosphatase, germ cell type (ALPG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[333]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[377]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[341]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[7]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[378]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[379]
Lithium chloride	DMHYLQ2	Discovery agent	N.A.	Investigative	[331]
Hydroxyestradiol	DMJXQME	N. A.	N. A.	Investigative	[377]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[380]

Drug(s) Affected By Serine/threonine-protein kinase pim-1 (PIM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[381]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[382]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[178]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[198]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[384]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]

Drug(s) Affected By Aminopeptidase N (ANPEP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[261]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[385]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[386]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[387]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[388]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]

Drug(s) Affected By Folate receptor alpha (FOLR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[389]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[171]
Bortezomib	DMNO38U	Leukemia		Approved	[270]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[186]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[390]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[335]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[305]

Drug(s) Affected By CCAAT/enhancer-binding protein beta (CEBPB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[391]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[250]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[392]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[393]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[368]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]

Drug(s) Affected By Diamine acetyltransferase 1 (SAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[394]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[234]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[395]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[395]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]

Drug(s) Affected By Interleukin-4 receptor subunit alpha (IL4R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[396]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[397]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[343]

Drug(s) Affected By Sodium- and chloride-dependent taurine transporter (SLC6A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[180]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[106]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[333]

Drug(s) Affected By G protein-activated inward rectifier potassium channel 4 (KCNJ5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[398]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[222]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[318]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[399]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[7]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[160]

Drug(s) Affected By Nuclear receptor-interacting protein 1 (NRIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[73]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[348]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[343]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[400]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[258]
Teniposide	DMLW57T	Acute lymphoblastic leukaemia	2A85	Approved	[401]

Drug(s) Affected By ADP-ribosylation factor-like protein 4D (ARL4D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[332]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[402]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[403]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[404]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]

Drug(s) Affected By CCAAT/enhancer-binding protein delta (CEBPD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[120]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[405]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[406]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[145]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[254]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]

Drug(s) Affected By Homeobox protein MOX-1 (MEOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[133]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[407]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[407]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[407]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[406]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[407]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[407]
Ramelteon	DM7IW9J	Insomnia	7A00-7A0Z	Approved	[407]

Drug(s) Affected By AF4/FMR2 family member 3 (AFF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[343]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[408]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[409]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[408]

Drug(s) Affected By Reelin (RELN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[410]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]

Drug(s) Affected By ETS-related transcription factor Elf-3 (ELF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[391]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[411]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[343]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]

Drug(s) Affected By Large neutral amino acids transporter small subunit 1 (SLC7A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[330]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[140]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[202]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[367]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[121]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[412]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[330]

Drug(s) Affected By Keratin, type I cytoskeletal 17 (KRT17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[413]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[244]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[62]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[413]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[62]

Drug(s) Affected By Lactadherin (MFGE8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[414]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[147]
Methyl aminolevulinate	DMIUX3D	Acne vulgaris	ED80	Approved	[415]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[180]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[64]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[416]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]

Drug(s) Affected By 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5 (FUT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[222]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[222]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]

Drug(s) Affected By Frizzled-5 (FZD5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[121]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[417]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]

Drug(s) Affected By Phakinin (BFSP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[335]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[120]

Drug(s) Affected By Inositol-tetrakisphosphate 1-kinase (ITPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[418]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[418]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[419]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[217]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]

Drug(s) Affected By Laminin subunit beta-3 (LAMB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[249]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[249]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[196]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[343]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[245]

Drug(s) Affected By Forkhead box protein D1 (FOXD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[391]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[61]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[121]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[222]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[239]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[341]

Drug(s) Affected By Protein GREB1 (GREB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[73]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[420]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[420]
Nandrolone	DMFWKG1	Osteoporosis	FB83.0	Approved	[65]
Mestranol	DMG3F94	Contraception	QA21	Approved	[420]

Drug(s) Affected By Extracellular tyrosine-protein kinase PKDCC (PKDCC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[421]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[337]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[337]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[409]

Drug(s) Affected By Protein Flattop (CFAP126)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[179]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[422]

Drug(s) Affected By Anoctamin-1 (ANO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[310]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[333]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Nimodipine	DMQ0RKZ	Cerebral vasospasm	BA85.Z	Approved	[423]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[424]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[222]

Drug(s) Affected By Proline-rich protein 5-like (PRR5L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[391]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[343]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[425]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[337]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[337]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[222]

Drug(s) Affected By Dynein axonemal intermediate chain 7 (DNAI7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[122]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[320]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[120]

Drug(s) Affected By Plexin domain-containing protein 2 (PLXDC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[332]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[180]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[340]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[366]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[426]

Drug(s) Affected By Isoaspartyl peptidase/L-asparaginase (ASRGL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[427]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[408]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[7]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]

Drug(s) Affected By Polypeptide N-acetylgalactosaminyltransferase 4 (GALNT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[428]
Bortezomib	DMNO38U	Leukemia		Approved	[270]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[139]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[7]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[7]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[120]

Drug(s) Affected By Ephexin-1 (NGEF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[429]

Drug(s) Affected By DEP domain-containing mTOR-interacting protein (DEPTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[120]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[430]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[171]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[180]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[340]

Drug(s) Affected By CDK5 and ABL1 enzyme substrate 1 (CABLES1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[431]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[337]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[64]

Drug(s) Affected By Docking protein 4 (DOK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[402]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[432]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[7]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[7]

Drug(s) Affected By Glycerophosphodiester phosphodiesterase domain-containing protein 5 (GDPD5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[125]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[105]

Drug(s) Affected By Glutathione-specific gamma-glutamylcyclotransferase 2 (CHAC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[125]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]

Drug(s) Affected By Forkhead box protein J1 (FOXJ1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[171]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[139]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[433]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[318]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[434]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[100]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[435]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 25 (TNFRSF25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[86]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[289]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[436]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[147]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[298]

Drug(s) Affected By Endoplasmic reticulum resident protein 27 (ERP27)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[205]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[205]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[171]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[106]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[333]

Drug(s) Affected By Phosphoinositide-3-kinase-interacting protein 1 (PIK3IP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[348]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[369]
Idelalisib	DM602WT	Chronic lymphocytic leukaemia	2A82.0	Approved	[437]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[198]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[145]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[369]

Drug(s) Affected By Hyaluronan and proteoglycan link protein 3 (HAPLN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[171]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[180]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[438]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[439]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[217]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[440]

Drug(s) Affected By Protein Niban 2 (NIBAN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[432]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[293]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[120]

Drug(s) Affected By Sphingosine 1-phosphate receptor 3 (S1PR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[441]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[237]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[340]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[442]

Drug(s) Affected By Neurturin (NRTN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[406]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[333]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[443]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[416]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[87]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[433]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]

Drug(s) Affected By Noelin (OLFM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[330]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[331]
Mestranol	DMG3F94	Contraception	QA21	Approved	[330]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[444]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[418]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[445]

Drug(s) Affected By Melanophilin (MLPH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[331]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[333]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[222]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[427]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[446]

Drug(s) Affected By Fibronectin type III domain-containing protein 11 (FNDC11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[222]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[120]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[414]

Drug(s) Affected By RNA-binding protein 24 (RBM24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[106]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[333]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[431]

Drug(s) Affected By Potassium voltage-gated channel subfamily F member 1 (KCNF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[125]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[222]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[7]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[447]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[218]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[7]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[448]

Drug(s) Affected By Transcription factor SOX-17 (SOX17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[449]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[449]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[449]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[449]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[449]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[449]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[450]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[171]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[449]
Ziprasidone	DMM58JY	Bipolar disorder	6A60	Approved	[449]

Drug(s) Affected By Prolyl hydroxylase EGLN3 (EGLN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[451]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[87]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[122]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[318]

Drug(s) Affected By 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[171]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Methamphetamine	DMPM4SK	Anxiety		Approved	[452]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[453]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[451]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[186]

Drug(s) Affected By Olfactomedin-like protein 3 (OLFML3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[454]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[455]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[333]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[186]

Drug(s) Affected By Ras-related protein Rab-20 (RAB20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[179]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[258]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[100]

Drug(s) Affected By A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[456]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[171]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[340]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[333]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[457]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]

Drug(s) Affected By Cilia- and flagella-associated protein 45 (CFAP45)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[139]

Drug(s) Affected By Transcription factor HES-2 (HES2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[414]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[171]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[333]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[222]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[7]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[458]

Drug(s) Affected By Lysosome-associated membrane glycoprotein 3 (LAMP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[208]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[454]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[311]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[459]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[459]

Drug(s) Affected By Cytochrome P450 2B6 (CYP2B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[460]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[461]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[462]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[463]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[464]
Clopidogrel	DMOL54H	Acute coronary syndrome	BA41	Approved	[465]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[466]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[467]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[468]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[469]

Drug(s) Affected By Bile salt export pump (ABCB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[470]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[471]
Glipizide	DMZA5PQ	Diabetic complication	5A2Y	Approved	[471]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[124]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[470]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[471]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[472]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[470]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[473]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[470]

Drug(s) Affected By Aldo-keto reductase family 1 member B10 (AKR1B10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[474]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[205]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[475]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[476]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[198]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[259]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[477]

Drug(s) Affected By Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (GCNT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[342]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[478]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[259]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[173]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[343]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]

Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[326]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[479]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[480]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[474]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[328]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[481]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[482]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[483]

Drug(s) Affected By F-box only protein 30 (FBXO30)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[484]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[173]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[173]

Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[326]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[372]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[372]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[372]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[249]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[485]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[368]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[372]

Drug(s) Affected By Histone chaperone ASF1A (ASF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[259]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[105]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[334]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]

Drug(s) Affected By Serine/threonine-protein kinase Sgk1 (SGK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[330]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[486]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[420]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[487]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[368]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[330]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[488]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]

Drug(s) Affected By Prostaglandin E synthase (PTGES)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[330]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[489]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[490]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[147]
Mestranol	DMG3F94	Contraception	QA21	Approved	[330]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[125]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]

Drug(s) Affected By Carbonic anhydrase 12 (CA12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetazolamide	DM1AF5U	Absence epilepsy		Approved	[491]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[330]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[205]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[330]
Topiramate	DM82Z30	Alcohol dependence	6C40.2	Approved	[350]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[492]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]

Drug(s) Affected By Tyrosine-protein kinase JAK2 (JAK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Momelotinib	DMF98Q0	Myelofibrosis	2A20.2	Approved	[493]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[330]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[494]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[330]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[196]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[495]

Drug(s) Affected By monooxygenase MICAL2 (MICAL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[496]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[330]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[330]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Mestranol	DMG3F94	Contraception	QA21	Approved	[330]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]

Drug(s) Affected By Serine protease 23 (PRSS23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[330]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[245]

Drug(s) Affected By Supervillin (SVIL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[120]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[293]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[330]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[208]
Mestranol	DMG3F94	Contraception	QA21	Approved	[330]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[332]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[171]

Drug(s) Affected By Transcription factor AP-2-alpha (TFAP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[497]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[330]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[498]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[499]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[497]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[173]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[173]

Drug(s) Affected By Proto-oncogene tyrosine-protein kinase receptor Ret (RET)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[182]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[330]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[182]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[500]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[330]
Methazolamide	DM7J2TA	Glaucoma/ocular hypertension	9C61	Approved	[182]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[501]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[343]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]

Drug(s) Affected By Monoacylglycerol lipase ABHD2 (ABHD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[330]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[330]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[141]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Mestranol	DMG3F94	Contraception	QA21	Approved	[330]
Bortezomib	DMNO38U	Leukemia		Approved	[270]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]

Drug(s) Affected By Transcriptional activator Myb (MYB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[330]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[269]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[502]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[170]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[330]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[503]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[384]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]

Drug(s) Affected By Myb-related protein A (MYBL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[330]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[420]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[504]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[330]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[101]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[208]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[420]

Drug(s) Affected By Tissue factor pathway inhibitor (TFPI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[330]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[330]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[505]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[179]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[454]

Drug(s) Affected By Delta-aminolevulinic acid dehydratase (ALAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[330]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[330]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[506]
Mestranol	DMG3F94	Contraception	QA21	Approved	[330]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[507]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[337]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[337]

Drug(s) Affected By Amphiregulin (AREG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[391]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[508]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[231]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[509]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[510]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[330]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[178]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[511]

Drug(s) Affected By CD44 antigen (CD44)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[261]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[330]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Selenium	DM25CGV	N. A.	N. A.	Approved	[512]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[513]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[514]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[515]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[516]

Drug(s) Affected By Ephrin-A1 (EFNA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[151]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[330]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[517]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[518]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[519]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[520]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[521]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[522]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[382]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[154]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[523]

Drug(s) Affected By Stromal cell-derived factor 1 (CXCL12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[133]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[330]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[524]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[121]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[330]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[525]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[526]

Drug(s) Affected By Ephrin type-A receptor 4 (EPHA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[330]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[527]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[330]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Mestranol	DMG3F94	Contraception	QA21	Approved	[330]

Drug(s) Affected By Single-stranded DNA-binding protein 2 (SSBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[330]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[406]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Mestranol	DMG3F94	Contraception	QA21	Approved	[330]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[528]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[330]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]

Drug(s) Affected By DNA-binding protein inhibitor ID-3 (ID3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[529]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[330]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[530]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[487]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[157]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[531]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[249]

Drug(s) Affected By Urokinase plasminogen activator surface receptor (PLAUR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[330]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[532]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[533]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[534]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[86]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[535]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[78]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]

Drug(s) Affected By Forkhead box protein C1 (FOXC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[330]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[536]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[330]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]

Drug(s) Affected By Kynureninase (KYNU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[330]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[348]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[330]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[86]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[179]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]

Drug(s) Affected By Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[330]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[303]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[330]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Mestranol	DMG3F94	Contraception	QA21	Approved	[330]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[431]

Drug(s) Affected By Dual specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[330]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[537]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[179]
Mestranol	DMG3F94	Contraception	QA21	Approved	[330]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[538]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[64]

Drug(s) Affected By Transcription factor AP-2 gamma (TFAP2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[330]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[330]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[86]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Mestranol	DMG3F94	Contraception	QA21	Approved	[330]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[455]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[539]

Drug(s) Affected By Serine/threonine-protein kinase Sgk3 (SGK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[330]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[330]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[141]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Mestranol	DMG3F94	Contraception	QA21	Approved	[330]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]

Drug(s) Affected By Inactive rhomboid protein 1 (RHBDF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[330]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[330]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Mestranol	DMG3F94	Contraception	QA21	Approved	[330]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[311]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[340]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[424]

Drug(s) Affected By Calmin (CLMN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[330]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[343]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Mestranol	DMG3F94	Contraception	QA21	Approved	[330]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[311]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[340]

Drug(s) Affected By Pleckstrin homology domain-containing family F member 2 (PLEKHF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[330]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Mestranol	DMG3F94	Contraception	QA21	Approved	[330]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[330]

Drug(s) Affected By Spermine oxidase (SMOX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[330]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[330]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Mestranol	DMG3F94	Contraception	QA21	Approved	[330]

Drug(s) Affected By Nicotinamide riboside kinase 1 (NMRK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[330]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[330]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[208]
Mestranol	DMG3F94	Contraception	QA21	Approved	[330]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[125]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[337]

Drug(s) Affected By Rap guanine nucleotide exchange factor-like 1 (RAPGEFL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[330]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[330]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Mestranol	DMG3F94	Contraception	QA21	Approved	[330]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[443]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[337]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[366]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]

Drug(s) Affected By RNA 3'-terminal phosphate cyclase-like protein (RCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[330]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[330]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[540]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Mestranol	DMG3F94	Contraception	QA21	Approved	[330]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]

Drug(s) Affected By Diphosphoinositol polyphosphate phosphohydrolase NUDT4B (NUDT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[121]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]

Drug(s) Affected By CBY1-interacting BAR domain-containing protein 1 (CIBAR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[122]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[541]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[542]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[543]

Drug(s) Affected By Protein FAM234B (FAM234B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[293]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[310]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[366]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[318]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[293]

Drug(s) Affected By Protein strawberry notch homolog 1 (SBNO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[343]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[254]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[293]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[100]

Drug(s) Affected By Cytosolic acyl coenzyme A thioester hydrolase (ACOT7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[544]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[169]
Bortezomib	DMNO38U	Leukemia		Approved	[270]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[545]

Drug(s) Affected By HCLS1-associated protein X-1 (HAX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[239]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[546]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[547]
MG-132	DMKA2YS	N. A.	N. A.	Preclinical	[548]

Drug(s) Affected By Receptor-binding cancer antigen expressed on SiSo cells (EBAG9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[549]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[549]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[293]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[550]
1,6-hexamethylene diisocyanate	DMLB3RT	Discovery agent	N.A.	Investigative	[551]

Drug(s) Affected By ATP-dependent RNA helicase DDX3X (DDX3X)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[552]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[553]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[334]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[554]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[122]

Drug(s) Affected By Stearoyl-CoA desaturase (SCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[474]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[555]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[555]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[157]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[61]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[555]
Fructose	DM43AN2	Vomiting	MD90	Approved	[556]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[555]

Drug(s) Affected By TRAF-type zinc finger domain-containing protein 1 (TRAFD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[173]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[173]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[173]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[173]
Bortezomib	DMNO38U	Leukemia		Approved	[270]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[173]

Drug(s) Affected By Chromodomain-helicase-DNA-binding protein 1 (CHD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[538]
Indomethacin	DMSC4A7	Bursitis		Approved	[557]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[139]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[160]

Drug(s) Affected By Transcription elongation regulator 1 (TCERG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[139]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[506]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]

Drug(s) Affected By Ras-related protein M-Ras (MRAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[78]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Febuxostat	DMDEXQ0	Hyperuricaemia	5C55.Y	Approved	[558]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[294]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[559]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[560]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[294]

Drug(s) Affected By Glutathione S-transferase 3, mitochondrial (MGST3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[205]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[340]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[222]

Drug(s) Affected By Peripheral plasma membrane protein CASK (CASK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[140]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[343]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[561]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]

Drug(s) Affected By 1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[74]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[340]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[402]

Drug(s) Affected By Mothers against decapentaplegic homolog 9 (SMAD9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[416]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[427]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[562]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[318]

Drug(s) Affected By Prefoldin subunit 6 (PFDN6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[120]

Drug(s) Affected By Monocarboxylate transporter 5 (SLC16A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[348]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[367]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[245]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[171]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[538]

Drug(s) Affected By Cytochrome P450 26A1 (CYP26A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[563]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[564]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[563]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[565]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[566]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[553]
Dolutegravir	DMCZGRE	Human immunodeficiency virus infection	1C62	Approved	[567]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[563]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[539]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[568]

Drug(s) Affected By Eukaryotic translation elongation factor 1 epsilon-1 (EEF1E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[334]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[424]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[122]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[569]

Drug(s) Affected By Pleiotropic regulator 1 (PLRG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[120]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[200]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[120]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[321]

Drug(s) Affected By Probable 18S rRNA (BUD23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[570]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[186]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[440]

Drug(s) Affected By E3 ubiquitin-protein ligase MARCHF6 (MARCHF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[571]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Betaine	DMGRZW2	Cystitis	GC00	Approved	[571]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[137]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[122]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[160]
ANW-32821	DMMJOZD	N. A.	N. A.	Phase 2	[571]
CB-5083	DM12GN7	Multiple myeloma	2A83	Phase 1	[571]

Drug(s) Affected By Vinexin (SORBS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[337]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[186]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[217]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[87]

Drug(s) Affected By Sorting nexin-2 (SNX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[332]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[506]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[572]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]

Drug(s) Affected By Polyglutamine-binding protein 1 (PQBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[208]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[147]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[293]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[573]

Drug(s) Affected By Ribonuclease H1 (RNASEH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[334]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[418]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[574]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[418]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[160]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[575]

Drug(s) Affected By Vesicle-trafficking protein SEC22b (SEC22B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[305]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[293]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[576]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[321]
Hexadecanoic acid	DMWUXDZ	Discovery agent	N.A.	Investigative	[577]

Drug(s) Affected By Erlin-1 (ERLIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[270]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[578]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[440]

Drug(s) Affected By Serine/arginine-rich splicing factor 10 (SRSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[334]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[579]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[569]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[172]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[281]

Drug(s) Affected By Claudin-11 (CLDN11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[340]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[580]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[581]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[582]

Drug(s) Affected By PR domain zinc finger protein 1 (PRDM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[198]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[145]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[173]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[173]
Ibrutinib	DMHZCPO	Mantle cell lymphoma	2A85.5	Approved	[583]

Drug(s) Affected By Nuclear pore complex protein Nup155 (NUP155)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[179]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[139]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]

Drug(s) Affected By Pre-mRNA-splicing factor SPF27 (BCAS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[426]
MG-132	DMKA2YS	N. A.	N. A.	Preclinical	[584]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[321]

Drug(s) Affected By DnaJ homolog subfamily C member 8 (DNAJC8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[294]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[294]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[281]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[585]

Drug(s) Affected By Stanniocalcin-2 (STC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[391]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[194]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[271]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[406]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[411]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[227]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[586]

Drug(s) Affected By Metastasis-associated protein MTA2 (MTA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[61]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[61]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[64]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[122]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[587]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[320]

Drug(s) Affected By Erlin-2 (ERLIN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Bortezomib	DMNO38U	Leukemia		Approved	[270]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[435]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[459]

Drug(s) Affected By F-box only protein 21 (FBXO21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[64]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[239]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]

Drug(s) Affected By NADH dehydrogenase 1 alpha subcomplex subunit 10, mitochondrial (NDUFA10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[120]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[588]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[302]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[213]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]

Drug(s) Affected By Importin-7 (IPO7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[76]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[589]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[64]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[334]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[572]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[590]

Drug(s) Affected By GDH/6PGL endoplasmic bifunctional protein (H6PD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[591]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[484]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[592]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[592]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Bortezomib	DMNO38U	Leukemia		Approved	[270]

Drug(s) Affected By Mitochondrial pyruvate carrier 2 (MPC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[121]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[171]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[64]

Drug(s) Affected By STAM-binding protein (STAMBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[121]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[163]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[593]
PF-3758309	DM36PKZ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[594]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[595]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[321]

Drug(s) Affected By Renin (REN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[596]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[597]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[598]
Reboxetine	DM26PRD	Depression	6A70-6A7Z	Approved	[599]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[600]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[601]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[602]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[603]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[604]
Chlorthalidone	DM4DMBT	Edema	MG29	Approved	[605]

Drug(s) Affected By Cystatin-A (CSTA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[151]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[301]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[167]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[368]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[235]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]

Drug(s) Affected By Prolactin (PRL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[606]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[607]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[608]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[609]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[157]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[610]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[611]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[612]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[613]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[614]

Drug(s) Affected By Fibronectin (FN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[615]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[157]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[616]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[617]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[618]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[121]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[417]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[619]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[436]

Drug(s) Affected By Estrogen receptor (ESR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[620]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[520]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[621]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[622]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[623]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[624]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[625]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[626]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[622]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[627]

Drug(s) Affected By Sex hormone-binding globulin (SHBG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[628]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Fructose	DM43AN2	Vomiting	MD90	Approved	[629]
Oxcarbazepine	DM5PU6O	Epilepsy	8A60-8A68	Approved	[630]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[631]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[632]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Dienestrol	DMBSXI0	Atrophic vaginitis	GA30.2	Approved	[631]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[631]
Masoprocol	DMMVNZ0	Prostate cancer	2C82.0	Approved	[631]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[633]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[157]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[634]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[635]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[636]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[637]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[638]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[639]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[640]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[641]

Drug(s) Affected By Guanine nucleotide-binding protein G(i) subunit alpha-2 (GNAI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[642]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[446]

Drug(s) Affected By Sodium/potassium-transporting ATPase subunit beta-1 (ATP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[412]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[86]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[254]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[334]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]

Drug(s) Affected By Lupus La protein (SSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[141]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[643]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[293]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[293]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[576]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[179]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[644]

Drug(s) Affected By Progesterone receptor (PGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[645]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[646]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[647]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[648]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[649]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[650]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[71]
Goserelin	DMAT8CG	Breast cancer	2C60-2C65	Approved	[651]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[652]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]

Drug(s) Affected By Prostate-specific antigen (KLK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[73]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[653]
Selenium	DM25CGV	N. A.	N. A.	Approved	[654]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[655]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[656]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[657]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[658]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[659]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[660]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]

Drug(s) Affected By Cathepsin B (CTSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[496]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[133]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[661]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Pyrimethamine	DM5X7VY	Malaria	1F40-1F45	Approved	[662]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[663]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[664]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[665]

Drug(s) Affected By Tropomyosin beta chain (TPM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[169]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[666]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[667]

Drug(s) Affected By Porphobilinogen deaminase (HMBS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[540]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Aclarubicin	DMLFZHD	Acute myeloid leukaemia	2A60	Approved	[668]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[545]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[669]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[670]

Drug(s) Affected By Steryl-sulfatase (STS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[249]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[249]
Tazarotene	DM8SMD1	Acne vulgaris	ED80	Approved	[671]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[179]
Danazol	DML8KTN	Menorrhagia	GA20.50	Approved	[672]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[671]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[249]

Drug(s) Affected By Gamma-enolase (ENO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[673]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[674]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[675]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[161]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[173]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]

Drug(s) Affected By Trafficking protein particle complex subunit 2 (TRAPPC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[554]

Drug(s) Affected By Protein POLR1D, isoform 2 (POLR1D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[239]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[217]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]

Drug(s) Affected By Adrenodoxin, mitochondrial (FDX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[676]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[440]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[321]

Drug(s) Affected By Serglycin (SRGN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[406]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[179]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[677]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[528]

Drug(s) Affected By Androgen receptor (AR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[678]
Nilutamide	DMFN07X	Prostate cancer	2C82.0	Approved	[678]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[678]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[679]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[680]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[645]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[681]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[682]
Selenium	DM25CGV	N. A.	N. A.	Approved	[654]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[683]

Drug(s) Affected By Osteopontin (SPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[684]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[73]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[685]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[686]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[201]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[687]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[342]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[412]

Drug(s) Affected By COUP transcription factor 1 (NR2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[688]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[121]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[343]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[689]

Drug(s) Affected By S-formylglutathione hydrolase (ESD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[208]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[179]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[186]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[572]
NVP-AUY922	DMTYXQF	Multiple myeloma	2A83	Phase 2	[690]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[201]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[691]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[692]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[169]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[693]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[693]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[367]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]

Drug(s) Affected By Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[157]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[201]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[694]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[695]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[311]

Drug(s) Affected By Protein disulfide-isomerase A4 (PDIA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[696]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[697]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[426]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[408]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[572]

Drug(s) Affected By Tissue factor (F3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[698]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[699]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[700]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[701]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[702]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[703]
Fructose	DM43AN2	Vomiting	MD90	Approved	[704]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[705]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[699]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[84]

Drug(s) Affected By Interferon gamma receptor 1 (IFNGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[261]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[566]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[706]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[707]

Drug(s) Affected By Beta-1,4-galactosyltransferase 1 (B4GALT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[235]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[343]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[179]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[340]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[708]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[708]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-2 (ATF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[150]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[709]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[710]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[711]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Bortezomib	DMNO38U	Leukemia		Approved	[270]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]

Drug(s) Affected By Ribosyldihydronicotinamide dehydrogenase (NQO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[121]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[712]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[478]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[713]

Drug(s) Affected By Natriuretic peptides B (NPPB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[714]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[715]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[716]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[717]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[718]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[719]

Drug(s) Affected By Early growth response protein 1 (EGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[227]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[231]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[252]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[90]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[375]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[720]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[360]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 1A (TNFRSF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[296]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[721]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[722]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[723]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[724]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[369]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[289]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[725]

Drug(s) Affected By Follistatin (FST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[381]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[726]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[727]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]

Drug(s) Affected By Ras-related protein Rab-3B (RAB3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[198]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[728]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[208]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[729]

Drug(s) Affected By Lactoperoxidase (LPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[730]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[730]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[730]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[730]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Sulfadiazine	DMTW3R8	Rheumatic fever	1B40-1B42	Approved	[730]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[730]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[730]

Drug(s) Affected By Brain-derived neurotrophic factor (BDNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Haloperidol	DM96SE0	Delirium		Approved	[731]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[73]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[732]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Bupivacaine	DM4PRFC	Anaesthesia	9A78.6	Approved	[733]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[734]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[343]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[227]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[150]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[184]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[735]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[271]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[736]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[720]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[252]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[737]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[738]

Drug(s) Affected By Insulin-like growth factor-binding protein 6 (IGFBP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[244]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[739]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[740]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[147]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]

Drug(s) Affected By Adenomatous polyposis coli protein (APC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[140]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[723]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[400]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[741]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[147]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[538]

Drug(s) Affected By Bromodomain-containing protein 2 (BRD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[173]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[141]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[173]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]

Drug(s) Affected By Proteasome subunit alpha type-2 (PSMA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[588]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[212]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]

Drug(s) Affected By Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase (MGAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[578]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[120]

Drug(s) Affected By G0/G1 switch protein 2 (G0S2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Selenium	DM25CGV	N. A.	N. A.	Approved	[742]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[205]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[167]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[196]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[198]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[343]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]

Drug(s) Affected By DNA repair nuclease/redox regulator APEX1 (APEX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[743]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[713]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[744]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[445]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[745]

Drug(s) Affected By Proteasome subunit beta type-4 (PSMB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[746]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[643]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[747]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[160]

Drug(s) Affected By Probable global transcription activator SNF2L1 (SMARCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[179]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[667]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[444]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[281]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[748]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[293]

Drug(s) Affected By RNA-binding motif, single-stranded-interacting protein 1 (RBMS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[64]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[559]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[554]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]

Drug(s) Affected By Myristoylated alanine-rich C-kinase substrate (MARCKS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[249]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[249]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[84]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[141]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]

Drug(s) Affected By Large ribosomal subunit protein uL11 (RPL12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[188]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[749]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[546]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[576]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[585]

Drug(s) Affected By Alpha-2-macroglobulin receptor-associated protein (LRPAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[405]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[750]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[239]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[576]

Drug(s) Affected By Oxytocin receptor (OXTR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[751]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[554]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[752]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[239]

Drug(s) Affected By Sorcin (SRI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[492]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[181]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[64]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[554]

Drug(s) Affected By Homeobox protein Hox-A10 (HOXA10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[167]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[753]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[754]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[445]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[753]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[447]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[336]

Drug(s) Affected By Homeobox protein Hox-A9 (HOXA9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[755]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[755]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[528]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[756]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[334]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[757]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
EPZ-004777	DMLN4V5	leukaemia	2A60-2B33	Investigative	[758]

Drug(s) Affected By Ribonucleoside-diphosphate reductase subunit M2 (RRM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[759]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[176]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[234]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[406]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[76]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]

Drug(s) Affected By 3-hydroxyisobutyrate dehydrogenase, mitochondrial (HIBADH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[64]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[545]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein H (HNRNPH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[247]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[760]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[761]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]

Drug(s) Affected By Stress-induced-phosphoprotein 1 (STIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[496]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[342]
Haloperidol	DM96SE0	Delirium		Approved	[169]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[189]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[169]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[169]
Mecamylamine	DMGQFYB	Essential hypertension	BA00	Approved	[189]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[246]

Drug(s) Affected By ETS-related transcription factor Elf-1 (ELF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[762]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[141]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]

Drug(s) Affected By Syntaxin-2 (STX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[122]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[763]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[140]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[764]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[201]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[765]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[766]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[767]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[768]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[769]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[770]

Drug(s) Affected By Sepiapterin reductase (SPR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[539]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[771]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[341]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]

Drug(s) Affected By Transcription factor SOX-5 (SOX5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[100]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[772]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[590]

Drug(s) Affected By Glutaredoxin-1 (GLRX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[231]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[773]

Drug(s) Affected By Aryl hydrocarbon receptor (AHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[73]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[774]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[775]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[776]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[777]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[778]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[779]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[780]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[781]

Drug(s) Affected By Transaldolase (TALDO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[121]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[782]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[173]

Drug(s) Affected By Adenylyl cyclase-associated protein 2 (CAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[783]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[171]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[419]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]

Drug(s) Affected By Trifunctional enzyme subunit alpha, mitochondrial (HADHA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[157]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[141]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[205]
Bortezomib	DMNO38U	Leukemia		Approved	[270]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[160]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[572]

Drug(s) Affected By N-alpha-acetyltransferase 10 (NAA10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[169]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[160]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[293]

Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[784]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[721]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[785]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[786]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[787]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[154]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[730]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[788]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[196]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[789]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[790]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[791]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[792]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[636]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[793]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[794]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[795]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[796]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[797]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[798]

Drug(s) Affected By Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (STT3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[160]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[547]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[595]

Drug(s) Affected By Guanine nucleotide exchange factor MSS4 (RABIF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[799]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[590]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[321]

Drug(s) Affected By DNA-binding protein inhibitor ID-4 (ID4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[171]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[800]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[451]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[729]

Drug(s) Affected By Glioma pathogenesis-related protein 1 (GLIPR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[801]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[254]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[179]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[270]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]

Drug(s) Affected By Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (PIP4K2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[537]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[802]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]

Drug(s) Affected By CCN family member 3 (CCN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[151]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[416]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[390]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[151]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[803]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[574]

Drug(s) Affected By Nuclear autoantigenic sperm protein (NASP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[179]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[454]

Drug(s) Affected By GMP synthase (GMPS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[804]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[572]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[805]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[293]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[293]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[806]

Drug(s) Affected By Rab GDP dissociation inhibitor beta (GDI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[666]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[64]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[186]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[433]

Drug(s) Affected By Palmitoyl-protein thioesterase 1 (PPT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[807]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[807]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[572]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[320]

Drug(s) Affected By Ras-related protein Rab-9A (RAB9A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[666]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[426]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[808]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[799]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[293]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[293]

Drug(s) Affected By Thiopurine S-methyltransferase (TPMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[296]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[809]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[810]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[811]
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[812]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[137]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[813]
Bendroflumethiazide	DM7EVLC	High blood pressure	BA00	Approved	[814]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]

Drug(s) Affected By Nuclear cap-binding protein subunit 2 (NCBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[756]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[172]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[440]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[100]

Drug(s) Affected By Rap1 GTPase-GDP dissociation stimulator 1 (RAP1GDS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[540]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[169]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[239]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[100]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]

Drug(s) Affected By Rho GDP-dissociation inhibitor 1 (ARHGDIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[140]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[209]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[674]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[815]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[783]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[81]

Drug(s) Affected By Spermine synthase (SMS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[249]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[249]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[249]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[249]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[249]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[816]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[817]

Drug(s) Affected By Stanniocalcin-1 (STC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[120]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[363]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[205]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[540]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[544]

Drug(s) Affected By Biliverdin reductase A (BLVRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[343]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[212]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[160]

Drug(s) Affected By Arfaptin-2 (ARFIP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[540]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[408]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[293]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[543]

Drug(s) Affected By Coatomer subunit alpha (COPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[137]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[805]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[293]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[547]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[293]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[120]

Drug(s) Affected By Phospholipase A and acyltransferase 3 (PLAAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[208]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[340]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[337]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[186]

Drug(s) Affected By Solute carrier family 12 member 2 (SLC12A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[674]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[818]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Furosemide	DMMQ8ZG	Congestive heart failure	BD10	Approved	[818]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[674]

Drug(s) Affected By Protein AF-10 (MLLT10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[122]

Drug(s) Affected By ATP synthase subunit f, mitochondrial (ATP5MF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[121]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[302]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[819]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[222]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]

Drug(s) Affected By Sestrin-3 (SESN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[820]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[821]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[332]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]

Drug(s) Affected By Actin, cytoplasmic 1 (ACTB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[140]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[209]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[822]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]

Drug(s) Affected By Large ribosomal subunit protein eL15 (RPL15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[169]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[145]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[428]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[310]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[205]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[581]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[239]

Drug(s) Affected By Transforming protein RhoA (RHOA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[285]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[80]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[823]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[824]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[62]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[825]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[826]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[827]

Drug(s) Affected By Protein transport protein Sec61 subunit alpha isoform 1 (SEC61A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[141]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[554]

Drug(s) Affected By Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 (DAD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[147]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[828]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[819]

Drug(s) Affected By Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PPP1CB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[721]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[829]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[783]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]

Drug(s) Affected By ADP-ribosylation factor 6 (ARF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[830]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Bortezomib	DMNO38U	Leukemia		Approved	[270]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[831]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[139]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[426]

Drug(s) Affected By Estrogen-related receptor gamma (ESRRG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[832]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[141]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[205]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[171]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[186]

Drug(s) Affected By Actin, aortic smooth muscle (ACTA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[833]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[834]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[835]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[836]
Pirfenidone	DM6VZFQ	Idiopathic pulmonary fibrosis	CB03.4	Approved	[837]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[224]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]

Drug(s) Affected By Ras-related protein Rap-1A (RAP1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[838]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[247]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[839]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[195]
Minodronate	DM50PMY	Osteoporosis	FB83.0	Approved	[840]
Risedronate	DM5FLTY	Bone Paget disease		Approved	[841]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[842]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[841]

Drug(s) Affected By Small ribosomal subunit protein eS25 (RPS25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[188]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[562]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[843]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[562]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[844]

Drug(s) Affected By DNA-directed RNA polymerases I, II, and III subunit RPABC5 (POLR2L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[120]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[340]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[337]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[337]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[426]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PPP2R2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[120]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[179]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Bortezomib	DMNO38U	Leukemia		Approved	[270]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[294]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[845]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]

Drug(s) Affected By Small ribosomal subunit protein RACK1 (RACK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[721]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[846]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[847]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[847]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[169]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[169]
Nandrolone	DMFWKG1	Osteoporosis	FB83.0	Approved	[848]

Drug(s) Affected By Actin, gamma-enteric smooth muscle (ACTG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[405]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[405]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[171]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[180]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]

Drug(s) Affected By Phosphoserine phosphatase (PSPH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[540]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[141]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[333]

Drug(s) Affected By Eukaryotic translation initiation factor 4 gamma 2 (EIF4G2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[849]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[849]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[849]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[147]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[850]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[64]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]

Drug(s) Affected By Butyrophilin subfamily 3 member A2 (BTN3A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[484]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[235]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[125]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]

Drug(s) Affected By Protein jagged-1 (JAG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[301]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[405]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[525]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[237]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[180]

Drug(s) Affected By Biogenesis of lysosome-related organelles complex 1 subunit 1 (BLOC1S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[222]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[459]
bilirubin	DMI0V4O	Discovery agent	N.A.	Investigative	[851]

Drug(s) Affected By High mobility group nucleosome-binding domain-containing protein 5 (HMGN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[135]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[390]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[139]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[122]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[852]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[281]

Drug(s) Affected By ADP-ribosylation factor 5 (ARF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[208]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[160]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[572]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[87]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[573]

Drug(s) Affected By Cytochrome c (CYCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[261]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[853]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[854]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[855]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[856]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[857]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[157]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[858]
Pefloxacin	DM49IGF	Gonococcal urethritis	1A70.0Y	Approved	[859]

Drug(s) Affected By Heat shock factor protein 1 (HSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[860]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[861]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[861]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[862]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[863]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[861]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[861]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[861]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[861]

Drug(s) Affected By Protein SET (SET)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[864]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[865]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[865]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[746]
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[744]

Drug(s) Affected By Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[169]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[120]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[555]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[555]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[363]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[555]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[74]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[205]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]

Drug(s) Affected By Protein Dr1 (DR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Haloperidol	DM96SE0	Delirium		Approved	[169]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[169]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[160]

Drug(s) Affected By cAMP-responsive element modulator (CREM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Bortezomib	DMNO38U	Leukemia		Approved	[270]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[866]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[222]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[122]

Drug(s) Affected By Caveolin-1 (CAV1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[519]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[73]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[867]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[868]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[869]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[513]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[101]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]

Drug(s) Affected By Antigen peptide transporter 2 (TAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[870]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[186]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[322]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[366]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[261]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[519]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[871]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[489]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[872]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[873]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[874]

Drug(s) Affected By Sialomucin core protein 24 (CD164)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[801]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[174]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[875]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]

Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 12 (PTPN12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[293]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Indomethacin	DMSC4A7	Bursitis		Approved	[557]

Drug(s) Affected By Serine/arginine-rich splicing factor 11 (SRSF11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[179]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[270]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[64]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]

Drug(s) Affected By Early growth response protein 3 (EGR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[330]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[121]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[674]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[406]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[198]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[343]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]

Drug(s) Affected By KH domain-containing, RNA-binding, signal transduction-associated protein 1 (KHDRBS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[169]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[169]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[137]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[64]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]

Drug(s) Affected By Rho GTPase-activating protein 1 (ARHGAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Bortezomib	DMNO38U	Leukemia		Approved	[270]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[805]

Drug(s) Affected By ATP-dependent RNA helicase A (DHX9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[247]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[695]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[773]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[64]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[866]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[334]

Drug(s) Affected By Calmodulin-regulated spectrin-associated protein 2 (CAMSAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[141]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[122]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[341]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]

Drug(s) Affected By Tripartite motif-containing protein 26 (TRIM26)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[487]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[487]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[487]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[64]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]

Drug(s) Affected By Protein Red (IK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[239]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[160]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[281]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein A0 (HNRNPA0)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tetracaine	DM9J6C2	Spinal anesthesia	MB40.3	Approved	[876]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[122]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[281]

Drug(s) Affected By Methanethiol oxidase (SELENBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[877]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[674]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[340]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[674]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[186]

Drug(s) Affected By S-phase kinase-associated protein 2 (SKP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[391]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[234]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[878]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[879]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]

Drug(s) Affected By Acid ceramidase (ASAH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[58]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[133]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[880]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[58]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[880]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[880]

Drug(s) Affected By Serine/threonine-protein kinase PRP4 homolog (PRP4K)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Indomethacin	DMSC4A7	Bursitis		Approved	[557]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[334]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[281]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]

Drug(s) Affected By Eukaryotic translation initiation factor 4E-binding protein 2 (EIF4EBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[62]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[864]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[881]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[62]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]

Drug(s) Affected By Transformer-2 protein homolog alpha (TRA2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[169]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[86]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[537]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[141]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]

Drug(s) Affected By Periodic tryptophan protein 1 homolog (PWP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[254]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[160]

Drug(s) Affected By Cullin-2 (CUL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[169]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[169]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[882]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]

Drug(s) Affected By Cullin-3 (CUL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[369]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[343]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[369]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[310]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[169]

Drug(s) Affected By GDP-L-fucose synthase (GFUS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[883]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[160]

Drug(s) Affected By Angio-associated migratory cell protein (AAMP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[884]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[885]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[160]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[844]

Drug(s) Affected By Transcription factor Dp-2 (TFDP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[121]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[886]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[147]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[333]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[451]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[887]

Drug(s) Affected By Four and a half LIM domains protein 2 (FHL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[120]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[271]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[330]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[406]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]

Drug(s) Affected By Translation initiation factor eIF2B subunit alpha (EIF2B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[294]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[850]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[304]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[433]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[294]
EMODIN	DMAEDQG	Coronavirus Disease 2019 (COVID-19)	1D6Y	Terminated	[888]

Drug(s) Affected By Eukaryotic initiation factor 4A-II (EIF4A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[179]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[125]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[294]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[334]

Drug(s) Affected By Caprin-1 (CAPRIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[889]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[270]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[890]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[845]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]

Drug(s) Affected By Squalene monooxygenase (SQLE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[571]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[891]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[205]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[484]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[343]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[208]

Drug(s) Affected By Golgin subfamily B member 1 (GOLGB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[400]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[169]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[408]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[572]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[892]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[893]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[352]
Artemether	DM48QOT	Malaria	1F40-1F45	Approved	[894]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[895]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[195]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[780]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[896]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[897]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]

Drug(s) Affected By Proteasome activator complex subunit 4 (PSME4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[247]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[141]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[179]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]

Drug(s) Affected By GTPase-activating protein and VPS9 domain-containing protein 1 (GAPVD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[293]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[506]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[122]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[805]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[293]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[193]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[321]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[550]

Drug(s) Affected By Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 (ACAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[400]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[218]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[406]

Drug(s) Affected By Inorganic pyrophosphatase (PPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[169]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Haloperidol	DM96SE0	Delirium		Approved	[169]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[169]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[169]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[340]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase kappa (PTPRK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[739]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[332]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[181]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[756]

Drug(s) Affected By Pumilio homolog 3 (PUM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[202]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[64]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[139]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[218]

Drug(s) Affected By Calponin-3 (CNN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[204]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[334]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[845]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[239]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 7 (PPP1R7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[141]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[294]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[186]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[294]

Drug(s) Affected By Thyroid receptor-interacting protein 6 (TRIP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[160]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[799]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]

Drug(s) Affected By Tubulin-specific chaperone C (TBCC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[538]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]

Drug(s) Affected By Coiled-coil domain-containing protein 85B (CCDC85B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[141]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[334]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[186]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[139]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[426]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[320]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]
UNC0379	DMD1E4J	Hepatocellular carcinoma	2C12.02	Preclinical	[898]

Drug(s) Affected By Histone-lysine N-methyltransferase EZH2 (EZH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[899]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[293]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[688]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[900]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[901]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]

Drug(s) Affected By DNA damage-binding protein 1 (DDB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[902]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[360]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[581]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[189]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[239]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[903]

Drug(s) Affected By Mitogen-activated protein kinase 14 (MAPK14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[904]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[496]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[479]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[905]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[906]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[178]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[288]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[907]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[908]

Drug(s) Affected By Large ribosomal subunit protein uL23m (MRPL23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[426]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[217]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]

Drug(s) Affected By Calcium/calmodulin-dependent protein kinase type IV (CAMK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[666]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[442]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[909]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[122]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[910]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[320]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[120]

Drug(s) Affected By Serine/arginine-rich splicing factor 7 (SRSF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[76]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[169]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]

Drug(s) Affected By Drebrin (DBN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[121]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[801]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[911]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[539]

Drug(s) Affected By V-type proton ATPase subunit F (ATP6V1F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[321]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[585]

Drug(s) Affected By DNA repair protein SWI5 homolog (SWI5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[883]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[321]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[550]

Drug(s) Affected By WD40 repeat-containing protein SMU1 (SMU1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[137]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[200]

Drug(s) Affected By N-acetylglucosamine-1-phosphotransferase subunits alpha/beta (GNPTAB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[454]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[341]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[341]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[799]

Drug(s) Affected By Protein FAM229B (FAM229B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[208]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[122]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[295]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[120]

Drug(s) Affected By Prolyl endopeptidase-like (PREPL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[121]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[142]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[310]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[142]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]

Drug(s) Affected By Programmed cell death protein 4 (PDCD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[912]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[913]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[912]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[369]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[914]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[198]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[912]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]

Drug(s) Affected By Protein Hikeshi (HIKESHI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[122]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[120]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[541]

Drug(s) Affected By Shugoshin 2 (SGO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[234]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]

Drug(s) Affected By Protein FAM133B (FAM133B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[321]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[414]

Drug(s) Affected By SH3 domain-containing protein 19 (SH3D19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[120]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[331]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[340]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]

Drug(s) Affected By Polynucleotide 5'-hydroxyl-kinase NOL9 (NOL9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[222]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[915]

Drug(s) Affected By Tumor protein p63-regulated gene 1-like protein (TPRG1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[179]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[179]

Drug(s) Affected By Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (PDZK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[330]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[121]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[674]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[122]
Mestranol	DMG3F94	Contraception	QA21	Approved	[330]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[171]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[708]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[708]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]

Drug(s) Affected By Early estrogen-induced gene 1 protein (EEIG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[454]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[205]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[708]
Estriol	DMOEM2I	Hormone deficiency	5A61.1	Approved	[708]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[560]

Drug(s) Affected By DEP domain-containing protein 1A (DEPDC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[234]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[406]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[171]

Drug(s) Affected By Serine/threonine-protein kinase MRCK alpha (CDC42BPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[86]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[137]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[866]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]

Drug(s) Affected By Threonylcarbamoyladenosine tRNA methylthiotransferase (CDKAL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[141]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[916]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[281]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[87]

Drug(s) Affected By SPRY domain-containing protein 7 (SPRYD7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[186]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[139]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[122]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[590]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[339]

Drug(s) Affected By Metalloreductase STEAP3 (STEAP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[425]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[186]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[222]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[318]

Drug(s) Affected By Secreted frizzled-related protein 4 (SFRP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Cyclothiazide	DMJ4AWC	Congestive heart failure	BD10	Approved	[917]
Perindopril	DMOPZDT	Hypertension	BA00-BA04	Approved	[917]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[416]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[318]

Drug(s) Affected By OTU domain-containing protein 7B (OTUD7B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[222]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[408]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[100]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[918]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[293]

Drug(s) Affected By Eukaryotic translation initiation factor 5A-1-like (EIF5AL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[440]

Drug(s) Affected By Rhomboid domain-containing protein 2 (RHBDD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[270]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[87]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[547]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[440]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[179]

Drug(s) Affected By tRNA N(3)-methylcytidine methyltransferase METTL2B (METTL2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[310]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[293]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[321]

Drug(s) Affected By Superkiller complex protein 3 (SKIC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[160]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[200]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[406]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[340]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[100]
2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE	DMNQL17	Discovery agent	N.A.	Investigative	[919]

Drug(s) Affected By Spindle assembly abnormal protein 6 homolog (SASS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[311]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[186]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[920]

Drug(s) Affected By Cytochrome P450 20A1 (CYP20A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[337]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[337]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[340]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[541]

Drug(s) Affected By Beta-1,3-glucosyltransferase (B3GLCT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[179]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[799]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[179]

Drug(s) Affected By Lysophospholipid acyltransferase 2 (MBOAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[121]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[198]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[419]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[408]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[542]

Drug(s) Affected By Protein O-mannosyl-transferase TMTC3 (TMTC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[208]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[122]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[239]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[406]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[595]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[179]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[100]

Drug(s) Affected By Centromere protein U (CENPU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[179]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[125]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[180]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]

Drug(s) Affected By Nucleolar protein 8 (NOL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[426]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[160]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[281]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[293]

Drug(s) Affected By Protein RUFY3 (RUFY3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[141]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[921]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[139]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]

Drug(s) Affected By BTB/POZ domain-containing protein KCTD9 (KCTD9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[426]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[408]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[191]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[440]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[554]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[644]

Drug(s) Affected By Eukaryotic translation initiation factor 3 subunit M (EIF3M)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[179]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]

Drug(s) Affected By G2/M phase-specific E3 ubiquitin-protein ligase (G2E3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[137]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]

Drug(s) Affected By Rab11 family-interacting protein 2 (RAB11FIP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[310]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[922]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[341]

Drug(s) Affected By Protein lifeguard 1 (GRINA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[120]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[560]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[222]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[923]

Drug(s) Affected By Neuroepithelial cell-transforming gene 1 protein (NET1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[343]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Indomethacin	DMSC4A7	Bursitis		Approved	[557]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[64]

Drug(s) Affected By Large ribosomal subunit protein mL55 (MRPL55)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[676]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[87]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[924]

Drug(s) Affected By Transmembrane emp24 domain-containing protein 4 (TMED4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[100]

Drug(s) Affected By Polypeptide N-acetylgalactosaminyltransferase 10 (GALNT10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[171]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[559]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[561]

Drug(s) Affected By Probable RNA-binding protein 23 (RBM23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[590]
Lithium chloride	DMHYLQ2	Discovery agent	N.A.	Investigative	[331]

Drug(s) Affected By Serine incorporator 5 (SERINC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[179]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[318]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[172]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[799]

Drug(s) Affected By Cullin-associated NEDD8-dissociated protein 1 (CAND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[334]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[191]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[100]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[748]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[191]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[595]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[179]

Drug(s) Affected By Transmembrane protein adipocyte-associated 1 (TPRA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[271]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[171]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[799]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[218]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]

Drug(s) Affected By Mitofusin-1 (MFN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[732]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[925]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[926]
Bortezomib	DMNO38U	Leukemia		Approved	[270]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]

Drug(s) Affected By PHD finger protein 6 (PHF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[179]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[122]

Drug(s) Affected By Cytoskeleton-associated protein 2-like (CKAP2L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[245]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[180]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[438]

Drug(s) Affected By Chondroitin sulfate synthase 2 (CHPF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[186]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]

Drug(s) Affected By GTP-binding protein 8 (GTPBP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[141]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[340]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[160]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]

Drug(s) Affected By Small integral membrane protein 20 (SMIM20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[883]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[573]

Drug(s) Affected By ARL14 effector protein (ARL14EP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[310]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[281]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]

Drug(s) Affected By Probable RNA-binding protein EIF1AD (EIF1AD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[179]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[845]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]

Drug(s) Affected By Zinc finger protein GLIS3 (GLIS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[186]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[87]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[318]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[408]

Drug(s) Affected By Zinc transporter 7 (SLC30A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[367]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[122]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[408]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[927]

Drug(s) Affected By Periphilin-1 (PPHLN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[293]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[281]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[293]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[293]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[120]
[3H]methyltrienolone	DMTSGOW	Discovery agent	N.A.	Investigative	[928]

Drug(s) Affected By FAD synthase (FLAD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[139]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[748]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[193]

Drug(s) Affected By Retinoic acid-induced protein 3 (GPRC5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[194]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[301]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[348]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[198]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[254]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[171]

Drug(s) Affected By Lysine-specific demethylase 2B (KDM2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[179]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[64]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]

Drug(s) Affected By Multiple coagulation factor deficiency protein 2 (MCFD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[121]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[408]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]

Drug(s) Affected By Phosphatidylinositol-glycan biosynthesis class X protein (PIGX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[340]

Drug(s) Affected By Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma (PIP4K2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[310]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[929]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[160]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]

Drug(s) Affected By E3 ubiquitin-protein ligase DTX3L (DTX3L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[366]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[122]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[318]

Drug(s) Affected By Histone deacetylase 7 (HDAC7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[293]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[930]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[931]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[122]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[932]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[933]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[217]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[320]

Drug(s) Affected By Pleckstrin homology-like domain family A member 1 (PHLDA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[391]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[198]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[141]

Drug(s) Affected By RING finger protein 141 (RNF141)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[310]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[270]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[340]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[340]

Drug(s) Affected By Sec1 family domain-containing protein 1 (SCFD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[819]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[772]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[819]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[934]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[340]

Drug(s) Affected By tRNA-splicing endonuclease subunit Sen15 (TSEN15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[179]
Bortezomib	DMNO38U	Leukemia		Approved	[270]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[122]

Drug(s) Affected By Stalled ribosome sensor GCN1 (GCN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[559]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[139]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[844]
chloropicrin	DMSGBQA	Discovery agent	N.A.	Investigative	[585]

Drug(s) Affected By Acidic leucine-rich nuclear phosphoprotein 32 family member B (ANP32B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[282]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[64]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[643]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[122]

Drug(s) Affected By Estrogen receptor beta (ESR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[73]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[935]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[936]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[937]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[938]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[939]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[940]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[941]
Mestranol	DMG3F94	Contraception	QA21	Approved	[942]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[943]

Drug(s) Affected By Ras-responsive element-binding protein 1 (RREB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[944]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[222]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[281]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[748]

Drug(s) Affected By Gamma-glutamyl hydrolase (GGH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[945]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[946]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[540]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[106]

Drug(s) Affected By BLOC-3 complex member HPS1 (HPS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[141]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[667]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[100]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]

Drug(s) Affected By GTP-binding protein Rit1 (RIT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[173]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[173]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[173]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[106]
Bortezomib	DMNO38U	Leukemia		Approved	[270]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]

Drug(s) Affected By Ninjurin-1 (NINJ1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[170]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[163]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[179]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[173]

Drug(s) Affected By Pre-rRNA-processing protein TSR2 homolog (TSR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[321]

Drug(s) Affected By Transmembrane protein 54 (TMEM54)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[337]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[337]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[122]

Drug(s) Affected By Endonuclease 8-like 2 (NEIL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[139]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[7]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[7]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[293]

Drug(s) Affected By Polyamine deacetylase HDAC10 (HDAC10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Bortezomib	DMNO38U	Leukemia		Approved	[270]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[318]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[217]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF25 (RNF25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[293]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[321]

Drug(s) Affected By Mitochondrial assembly of ribosomal large subunit protein 1 (MALSU1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]

Drug(s) Affected By C1GALT1-specific chaperone 1 (C1GALT1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[340]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[64]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[947]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[426]

Drug(s) Affected By Corrinoid adenosyltransferase MMAB (MMAB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[186]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[845]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]

Drug(s) Affected By PDZ and LIM domain protein 5 (PDLIM5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]
Haloperidol	DM96SE0	Delirium		Approved	[169]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[310]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[169]

Drug(s) Affected By Small integral membrane protein 10 (SMIM10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[120]

Drug(s) Affected By DnaJ homolog subfamily C member 1 (DNAJC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[293]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[195]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[186]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[948]

Drug(s) Affected By Histone-lysine N-methyltransferase, H3 lysine-36 specific (NSD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[949]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[281]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[293]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[950]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[179]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[550]

Drug(s) Affected By Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 (PCMTD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[400]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[180]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[139]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[122]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[100]

Drug(s) Affected By Dedicator of cytokinesis protein 7 (DOCK7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[845]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[100]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[218]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[293]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[120]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[541]

Drug(s) Affected By Erbin (ERBIN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[120]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[163]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[64]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[559]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]

Drug(s) Affected By Selenocysteine insertion sequence-binding protein 2 (SECISBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[337]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[337]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[426]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[951]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]

Drug(s) Affected By 26S proteasome non-ATPase regulatory subunit 1 (PSMD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[76]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Lithium	DMZ3OU6	Bipolar disorder	6A60	Phase 2	[952]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[281]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[293]

Drug(s) Affected By E3 ubiquitin-protein ligase RING2 (RNF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[343]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Bortezomib	DMNO38U	Leukemia		Approved	[270]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[426]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[293]

Drug(s) Affected By G-protein coupled estrogen receptor 1 (GPER1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[914]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[808]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[914]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[205]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[627]

Drug(s) Affected By Cell division cycle-associated protein 3 (CDCA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[348]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[953]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[179]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[245]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]

Drug(s) Affected By COP9 signalosome complex subunit 8 (COPS8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[122]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[120]

Drug(s) Affected By Lysosomal-trafficking regulator (LYST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[431]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[451]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[139]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[426]

Drug(s) Affected By Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[539]
Bortezomib	DMNO38U	Leukemia		Approved	[270]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[528]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[954]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[293]

Drug(s) Affected By Homeobox protein Nkx-3.1 (NKX3-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[655]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[955]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[408]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[956]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[957]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[958]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[959]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[756]

Drug(s) Affected By T-complex protein 1 subunit eta (CCT7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[169]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[169]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[188]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[643]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[281]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[293]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[576]

Drug(s) Affected By Plakophilin-2 (PKP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[198]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]

Drug(s) Affected By Actin-related protein 2/3 complex subunit 5-like protein (ARPC5L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[193]

Drug(s) Affected By Target of rapamycin complex 2 subunit MAPKAP1 (MAPKAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[496]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Bortezomib	DMNO38U	Leukemia		Approved	[270]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[756]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[960]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[239]

Drug(s) Affected By Protein CMSS1 (CMSS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[756]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[569]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[218]

Drug(s) Affected By Vesicle-trafficking protein SEC22c (SEC22C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[311]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[554]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[179]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[542]

Drug(s) Affected By Nucleolar protein 10 (NOL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[139]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[961]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[281]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]

Drug(s) Affected By Deubiquitinase DESI2 (DESI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[202]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[141]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[137]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[64]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]

Drug(s) Affected By NEDD4 family-interacting protein 1 (NDFIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[239]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[554]

Drug(s) Affected By Plasma alpha-L-fucosidase (FUCA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[553]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[426]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
CH-223191	DMMJZYC	Solid tumour/cancer	2A00-2F9Z	Investigative	[962]

Drug(s) Affected By Acireductone dioxygenase (ADI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[137]
Dutasteride	DMQ4TJK	Benign prostatic hyperplasia	GA90	Approved	[660]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[337]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[337]

Drug(s) Affected By Guanine nucleotide-binding protein-like 3 (GNL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[208]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[205]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[139]

Drug(s) Affected By TM2 domain-containing protein 1 (TM2D1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[337]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[337]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[321]

Drug(s) Affected By Ion channel TACAN (TMEM120A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[205]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[843]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[87]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[576]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[321]

Drug(s) Affected By GTP-binding protein 4 (GTPBP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[169]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[64]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[139]

Drug(s) Affected By Protein Niban 1 (NIBAN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[963]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[198]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[343]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[953]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[208]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[454]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[171]

Drug(s) Affected By Tripartite motif-containing protein 5 (TRIM5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[139]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[432]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[408]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[961]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[120]

Drug(s) Affected By Phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[120]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[125]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[964]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[87]

Drug(s) Affected By Transmembrane protein 222 (TMEM222)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[337]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[337]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[446]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[160]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[293]

Drug(s) Affected By Large ribosomal subunit protein uL18m (MRPL18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[676]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[87]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[87]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[547]

Drug(s) Affected By Inhibitor of growth protein 2 (ING2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[281]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[321]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[965]

Drug(s) Affected By Cysteine-rich and transmembrane domain-containing protein 1 (CYSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[208]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[337]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[337]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[122]

Drug(s) Affected By Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (NUCKS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[142]
Bortezomib	DMNO38U	Leukemia		Approved	[270]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[144]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[265]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]

Drug(s) Affected By Inorganic pyrophosphatase 2, mitochondrial (PPA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[545]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[222]

Drug(s) Affected By Mitochondrial translation release factor in rescue (MTRFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[965]

Drug(s) Affected By Aminopeptidase B (RNPEP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[426]

Drug(s) Affected By TATA box-binding protein-associated factor RNA polymerase I subunit D (TAF1D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[921]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[426]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[239]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[160]

Drug(s) Affected By Transmembrane protein 134 (TMEM134)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[222]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[341]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[341]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[341]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]

Drug(s) Affected By Prostaglandin E synthase 2 (PTGES2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
PIRINIXIC ACID	DM82Y75	Pulmonary fibrosis	CB03.4	Preclinical	[966]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[193]

Drug(s) Affected By Coenzyme Q-binding protein COQ10 homolog B, mitochondrial (COQ10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[426]

Drug(s) Affected By Queuine tRNA-ribosyltransferase accessory subunit 2 (QTRT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[139]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[550]

Drug(s) Affected By Sideroflexin-1 (SFXN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[135]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[341]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[341]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[918]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]

Drug(s) Affected By Ribosome production factor 1 (RPF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]

Drug(s) Affected By Probable cysteine--tRNA ligase, mitochondrial (CARS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[545]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[426]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[805]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]

Drug(s) Affected By Melanoma-associated antigen F1 (MAGEF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[64]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[426]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[967]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[281]

Drug(s) Affected By MYG1 exonuclease (MYG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[545]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[576]

Drug(s) Affected By Calcyclin-binding protein (CACYBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[282]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[414]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[334]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]

Drug(s) Affected By Kinetochore protein Spc25 (SPC25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[234]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[406]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[953]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]

Drug(s) Affected By E3 SUMO-protein ligase KIAA1586 (KIAA1586)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[122]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[281]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[440]
RESORCINOL	DMM37C0	Discovery agent	N.A.	Investigative	[106]

Drug(s) Affected By Golgi-associated PDZ and coiled-coil motif-containing protein (GOPC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[64]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[281]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[293]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[321]

Drug(s) Affected By Transcription factor 7-like 2 (TCF7L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[968]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[388]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[311]
Bortezomib	DMNO38U	Leukemia		Approved	[969]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[137]

Drug(s) Affected By N-lysine methyltransferase KMT5A (KMT5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[970]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[971]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[972]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[973]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[805]

Drug(s) Affected By Translation initiation factor eIF2B subunit gamma (EIF2B3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[121]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[845]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[439]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[281]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[218]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]

Drug(s) Affected By Cytochrome P450 26B1 (CYP26B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[974]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[343]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[425]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[333]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[337]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[335]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]

Drug(s) Affected By Bromodomain adjacent to zinc finger domain protein 1A (BAZ1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[120]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[141]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Indomethacin	DMSC4A7	Bursitis		Approved	[557]

Drug(s) Affected By Lymphoid-specific helicase (HELLS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[179]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[180]

Drug(s) Affected By Transmembrane 7 superfamily member 3 (TM7SF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[975]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[553]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[750]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[87]

Drug(s) Affected By Phenylalanine--tRNA ligase beta subunit (FARSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[169]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[137]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[64]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[139]

Drug(s) Affected By Biogenesis of lysosome-related organelles complex 1 subunit 4 (BLOC1S4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[321]

Drug(s) Affected By Cell cycle control protein 50A (TMEM30A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[179]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[270]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[120]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[554]

Drug(s) Affected By ATPase family AAA domain-containing protein 3A (ATAD3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[169]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[333]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[139]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[439]

Drug(s) Affected By ADP-ribosylation factor-like protein 8B (ARL8B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[239]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]

Drug(s) Affected By Armadillo repeat-containing protein 1 (ARMC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[293]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[293]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[193]

Drug(s) Affected By Protein SDA1 homolog (SDAD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[139]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]

Drug(s) Affected By Arginine and glutamate-rich protein 1 (ARGLU1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[282]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[271]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[179]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[122]

Drug(s) Affected By CXXC motif containing zinc binding protein (CZIB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[546]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[844]

Drug(s) Affected By COMM domain-containing protein 8 (COMMD8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[845]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[122]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[321]

Drug(s) Affected By PH and SEC7 domain-containing protein 3 (PSD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[801]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[179]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[431]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[756]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]

Drug(s) Affected By CDGSH iron-sulfur domain-containing protein 1 (CISD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[545]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[554]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[967]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]

Drug(s) Affected By Methionine adenosyltransferase 2 subunit beta (MAT2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[169]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[976]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[977]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[844]

Drug(s) Affected By Cysteine-rich motor neuron 1 protein (CRIM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[101]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[141]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[368]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]

Drug(s) Affected By Protein PALS2 (PALS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[337]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[337]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[175]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[222]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[426]

Drug(s) Affected By COMM domain-containing protein 9 (COMMD9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[239]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[595]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[541]

Drug(s) Affected By Cysteine-rich PDZ-binding protein (CRIPT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[121]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[341]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[293]

Drug(s) Affected By Serine/threonine-protein kinase pim-2 (PIM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[179]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[171]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]

Drug(s) Affected By Dolichol-phosphate mannosyltransferase subunit 3 (DPM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[173]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[173]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[340]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[173]

Drug(s) Affected By Carboxypeptidase A4 (CPA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[194]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[75]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[343]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[245]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[171]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[180]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[186]

Drug(s) Affected By GTP:AMP phosphotransferase AK3, mitochondrial (AK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[173]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[173]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[173]

Drug(s) Affected By SH3 domain-binding glutamic acid-rich-like protein 2 (SH3BGRL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[205]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[186]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[321]

Drug(s) Affected By Motile sperm domain-containing protein 1 (MOSPD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[121]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[179]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[426]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[81]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[120]

Drug(s) Affected By Inhibitor of growth protein 1 (ING1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[147]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[337]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[108]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[978]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[550]

Drug(s) Affected By Polypyrimidine tract-binding protein 2 (PTBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[74]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[332]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[189]

Drug(s) Affected By TRAF2 and NCK-interacting protein kinase (TNIK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[198]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[208]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[921]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[335]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[100]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[318]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[100]

Drug(s) Affected By DCC-interacting protein 13-alpha (APPL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[979]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[293]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[980]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[120]

Drug(s) Affected By CASP8-associated protein 2 (CASP8AP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[391]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[147]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[981]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[882]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[572]

Drug(s) Affected By Apoptotic chromatin condensation inducer in the nucleus (ACIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[163]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[864]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[294]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[819]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[294]

Drug(s) Affected By Protein argonaute-2 (AGO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[120]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[162]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[537]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[343]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[179]

Drug(s) Affected By Neudesin (NENF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[222]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[122]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[160]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[576]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[321]

Drug(s) Affected By Proliferation-associated protein 2G4 (PA2G4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[202]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[815]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[310]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[81]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[334]

Drug(s) Affected By C-C motif chemokine 26 (CCL26)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[685]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[331]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[982]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[239]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[983]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[100]

Drug(s) Affected By Exocyst complex component 6B (EXOC6B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[414]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[318]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[572]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[799]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[984]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]

Drug(s) Affected By Kelch-like protein 20 (KLHL20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[340]
Bortezomib	DMNO38U	Leukemia		Approved	[270]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[160]

Drug(s) Affected By Axin-2 (AXIN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[196]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[332]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[302]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[985]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[561]

Drug(s) Affected By AP-3 complex subunit mu-1 (AP3M1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[104]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[100]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[644]

Drug(s) Affected By Nucleolar protein 58 (NOP58)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[64]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[139]

Drug(s) Affected By RRP15-like protein (RRP15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[414]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[390]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[222]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]

Drug(s) Affected By Methionine-R-sulfoxide reductase B2, mitochondrial (MSRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[101]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[311]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[64]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[528]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[186]

Drug(s) Affected By DmX-like protein 1 (DMXL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[963]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[504]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[963]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[400]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF115 (RNF115)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[845]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[107]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[172]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[961]

Drug(s) Affected By U6 snRNA-associated Sm-like protein LSm5 (LSM5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[122]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[110]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[292]

Drug(s) Affected By RNA-binding protein 7 (RBM7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[145]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[554]

Drug(s) Affected By NEDD8 ultimate buster 1 (NUB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Bortezomib	DMNO38U	Leukemia		Approved	[270]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[337]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[337]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[264]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[122]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[120]

Drug(s) Affected By Glypican-6 (GPC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[100]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[540]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[77]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[77]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[95]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[340]

Drug(s) Affected By Roundabout homolog 1 (ROBO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[92]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[101]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[136]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[986]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[119]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[187]

Drug(s) Affected By Sulfotransferase 2A1 (SULT2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[62]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[62]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[195]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[87]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[553]

Drug(s) Affected By Sulfotransferase 1A1 (SULT1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[186]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[987]
Minoxidil	DMA2Z4F	Alopecia	ED70	Approved	[988]
Benzyl alcohol	DMBVYDI	Head and body lice	1G00.0	Approved	[989]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[988]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[306]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[307]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[134]

Drug(s) Affected By Glutathione peroxidase 1 (GPX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[735]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Amlexanox	DM0DQM5	Respiratory tract inflammation	CA07	Approved	[990]
Selenium	DM25CGV	N. A.	N. A.	Approved	[991]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[992]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[993]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[90]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[167]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[994]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[995]

Drug(s) Affected By Sulfotransferase 1B1 (SULT1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzyl alcohol	DMBVYDI	Head and body lice	1G00.0	Approved	[989]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[186]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[565]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[79]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[996]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[997]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[998]
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[999]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[1000]

Drug(s) Affected By Sulfotransferase 1A3 (SULT1A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[186]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[739]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[309]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[539]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[538]
Vitamin C	DMXJ7O8	Adenocarcinoma	2D40	Approved	[1001]
Benzyl alcohol	DMBVYDI	Head and body lice	1G00.0	Approved	[989]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[988]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[988]

Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[1002]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[1002]
Etoricoxib	DM6A4NW	Rheumatoid arthritis	FA20	Approved	[1002]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[1003]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[1004]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[1005]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[1006]
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[1007]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[1008]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[296]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Estrogen receptor (ESR)	TTZAYWL	ESR1_HUMAN	Agonist	[2]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[3]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[4]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Substrate	[5]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2)	OT5I4Y9K	PLCB_HUMAN	Gene/Protein Processing	[6]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1)	OT9HYT7A	PLCB1_HUMAN	Gene/Protein Processing	[7]
14-3-3 protein beta/alpha	OTGBS3RF	1433B_HUMAN	Gene/Protein Processing	[8]
17-beta-hydroxysteroid dehydrogenase type 1 (HSD17B1)	OT6EBDHM	DHB1_HUMAN	Gene/Protein Processing	[9]
26S proteasome non-ATPase regulatory subunit 1 (PSMD1)	OTW258OV	PSMD1_HUMAN	Gene/Protein Processing	[6]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1)	OTNAZVKB	3BHS1_HUMAN	Gene/Protein Processing	[9]
3-hydroxyisobutyrate dehydrogenase, mitochondrial (HIBADH)	OTCMMMIZ	3HIDH_HUMAN	Gene/Protein Processing	[6]
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5 (FUT5)	OTOPGL9M	FUT5_HUMAN	Gene/Protein Processing	[7]
5-hydroxymethyl-dUMP N-hydrolase (DNPH1)	OTEZVTI1	DNPH1_HUMAN	Gene/Protein Processing	[8]
A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9)	OTV3Q0DS	ATS9_HUMAN	Gene/Protein Processing	[7]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2801).
• [2] Effects of diethylstilbestrol on programmed oocyte death and induction of polyovular follicles in neonatal mouse ovaries. Biol Reprod. 2009 Nov;81(5):1002-9.
• [3] Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92.
• [4] Comparative analysis of human CYP3A4 and rat CYP3A1 induction and relevant gene expression by bisphenol A and diethylstilbestrol: implications for toxicity testing paradigms. Reprod Toxicol. 2013 Jun;37:24-30.
• [5] Reversible inhibition of four important human liver cytochrome P450 enzymes by diethylstilbestrol. Pharmazie. 2011 Mar;66(3):216-21.
• [6] Identification of biomarkers and outcomes of endocrine disruption in human ovarian cortex using In Vitro Models. Toxicology. 2023 Feb;485:153425. doi: 10.1016/j.tox.2023.153425. Epub 2023 Jan 5.
• [7] Gene expression profiling in Ishikawa cells: a fingerprint for estrogen active compounds. Toxicol Appl Pharmacol. 2009 Apr 1;236(1):85-96.
• [8] Analysis of gene expression induced by diethylstilbestrol (DES) in human primitive Mullerian duct cells using microarray. Cancer Lett. 2005 Apr 8;220(2):197-210.
• [9] Estrogenic endocrine disruptive components interfere with calcium handling and differentiation of human trophoblast cells. J Cell Biochem. 2003 Jul 1;89(4):755-70.
• [10] Modulators of vascular sex hormone receptors and their effects in estrogen-deficiency states associated with menopause. Recent Pat Cardiovasc Drug Discov. 2008 Nov;3(3):165-86.
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