Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMUTEX3)

• Drug Name: Amiodarone Drug Info
• Synonyms: Amidorone; Aminodarone; Amiobeta; Amiodarex; Amiodarona; Amiodarons; Amiodaronum; Amiohexal; Amjodaronum; Ancar; Aratac;Arycor; Braxan; Corbionax; Cordarex; Cordarone; Kordaron; Labaz; Ortacrone; Pacerone; Rytmarone; Sedacoron; Sedacorone; Tachydaron; ASTA Medica Brand of Amiodarone Hydrochloride; Alphapharm Brand of Amiodarone Hydrochloride; Amiodarone Base; Armstrong Brand of Amiodarone Hydrochloride; Berenguer Infale Brand of Amiodarone Hydrochloride; Betapharm Brand of Amiodarone Hydrochloride; Cordarone Intravenous; G Gam Brand of Amiodarone Hydrochloride; Hexal Brand of Amiodarone Hydrochloride; Leurquin Brand of Amiodarone Hydrochloride; Pharma Investi Brand of Amiodarone Hydrochloride; Sanofi Winthrop Brand of Amiodarone Hydrochloride; Wyeth Brand of Amiodarone Hydrochloride; Ethylaminoethoxy)benzoyl]benzofuran; L 3428; L3428; SKF 33134A; Amio-Aqueous IV; Amiodarona [INN-Spanish]; Amiodaronum [INN-Latin]; Aratac (TN); Arycor (TN); Atlansil (TN); Cordarone (TN); L-3428; Pacerone (TN); Pms-Amiodarone; SKF 33134-A; Amiodarone (USAN/INN); Amiodarone [USAN:BAN:INN]; Ketone, 2-butyl-3-benzofuranyl 4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl; Ketone, 2-butyl-3-benzofuranyl 4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl (7CI,8CI); (2-Butyl-3-benzofuranyl)(4-(2-(diethylamino)ethoxy)-3,5-diidophenyl)methanone; (2-butyl-1-benzofuran-3-yl)(4-{[2-(diethylamino)ethyl]oxy}-3,5-diiodophenyl)methanone; (2-butyl-1-benzofuran-3-yl)-[4-(2-diethylaminoethyloxy)-3,5-diiodophenyl]methanone; (2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone; (2-butylbenzofuran-3-yl)-[4-(2-diethylaminoethoxy)-3,5-diiodo-phenyl]-methanone; (2-{4-[(2-butyl-1-benzofuran-3-yl)carbonyl]-2,6-diiodophenoxy}ethyl)diethylamine; 2-Butyl-3-(3,5-diiodo-4-(2-diethylaminoethoxy)benzoyl)benzofuran; 2-Butyl-3-(3,5-diiodo-4-(beta-diethylaminoethoxy)benzoyl)benzofuran; 2-Butyl-3-(4'-beta-N-diethylaminoethoxy-3',5'-diiodobenzoyl)benzofuran; 2-Butyl-3-[3,5-diiodo-4-(2-di; 2-Butyl-3-benzofuranyl 4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl ketone; 2-Butyl-3-benzofuranyl p-((2-diethylamino)ethoxy)-m,m-diiodophenyl ketone; 2-Butyl-3-benzofuranyl p-[(2-diethylamino)ethoxy]-m,m-diiodophenyl ketone; 2-n-Butyl-3',5'-diiodo-4'-N-diethylaminoethoxy-3-benzoylbenzofuran

Indication

Disease Entry	ICD 11	Status	REF
Tachyarrhythmias	BC71	Approved	[1]
Ventricular tachycardia	BC71	Approved	[2]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 2/3	[3]

• Therapeutic Class: Antiarrhythmic Agents
• Cross-matching ID:
  PubChem CID: 2157
  ChEBI ID: CHEBI:2663
  CAS Number: CAS 1951-25-3
  TTD Drug ID: DMUTEX3
  VARIDT Drug ID: DR00642
  INTEDE Drug ID: DR0093
  ACDINA Drug ID: D00031

Molecule-Related Drug Atlas

Drug(s) Targeting Potassium channel unspecific (KC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nateglinide	DMLK2QH	Diabetic complication	5A2Y	Approved	[4]
Dronedarone	DMA8FS5	Angina pectoris	BA40	Approved	[16]
Dofetilide	DMPN1TW	Sinus rhythm disorder	BC9Y	Approved	[4]
Amifampridine	DMK08L3	LambertEaton myasthenic syndrome	8C62	Approved	[17]
Minoxidil	DMA2Z4F	Alopecia	ED70	Approved	[4]
Pinacidil	DMRADYL	High blood pressure	BA00	Approved	[4]
Dalfampridine	DMM0PDO	Multiple sclerosis	8A40	Approved	[18]
Ibutilide	DMKXY2R	Atrial fibrillation	BC81.3	Approved	[4]
Diazoxide	DML1538	Congenital hyperinsulinism	5A4Y	Approved	[4]
Azimilide	DMUIBV8	Atrial fibrillation	BC81.3	Phase 3	[19]

Drug(s) Targeting HUMAN two pore channel subtype 2 (TPC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[5]

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[20]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[21]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[6]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[22]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[6]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[6]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[23]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[6]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[24]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[25]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[26]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[27]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[28]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[29]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[30]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[31]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[32]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[33]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[27]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[9]
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[80]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[81]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[82]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[83]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[84]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[84]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[85]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[86]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[87]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[88]

Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[34]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[35]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[36]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[39]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[32]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[40]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[41]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[42]
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[162]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[162]
Etoricoxib	DM6A4NW	Rheumatoid arthritis	FA20	Approved	[162]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[95]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[163]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[164]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[165]
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[166]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[167]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[109]

Drug(s) Metabolized By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[43]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[44]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[45]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[46]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[40]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[47]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[48]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[49]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[50]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[51]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[904]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[905]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[906]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[907]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[908]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[368]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[792]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[462]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[909]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[910]

Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[52]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[53]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[54]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[30]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[9]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[55]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[56]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[57]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[58]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[59]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[89]
Paliperidone	DM7NPJS	Psychotic disorder	6A20-6A25	Approved	[90]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[91]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[92]
Oxatomide	DM1F42Z	Hay fever	CA08.00	Approved	[93]
Cinacalcet	DMCX0K3	Hyperparathyroidism	5A51	Approved	[94]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[95]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[84]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[96]
Buprenorphine	DMPRI8G	Opioid dependence	6C43.2Z	Approved	[97]

Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[34]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[60]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[60]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[61]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[62]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[63]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[64]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[60]
Mycophenolate mofetil	DMPQAGE	Hepatosplenic T-cell lymphoma		Approved	[65]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[66]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[136]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[137]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[136]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[137]
Sulfinpyrazone	DMEV954	Gout	FA25	Approved	[138]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[136]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[136]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[136]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[139]
Dabrafenib	DMX6OE3	Melanoma	2C30	Approved	[140]

Drug(s) Metabolized By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[67]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[68]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[69]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[61]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[70]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[61]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[71]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[72]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[81]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[98]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[84]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[83]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[95]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[99]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[84]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[100]
Fluconazole	DMOWZ6B	Cryptococcal meningitis		Approved	[83]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[84]

Drug(s) Metabolized By Mephenytoin 4-hydroxylase (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[75]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[67]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[76]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[77]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[61]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[78]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[47]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[79]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[66]

Drug(s) Affected By Potassium voltage-gated channel subfamily H member 2 (KCNH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metoclopramide	DMFA5MY	Nausea	MD90	Approved	[101]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[102]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[103]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[104]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[104]
Disopyramide	DM5SYZP	Long QT syndrome	BC65.0	Approved	[105]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[106]
Dofetilide	DMPN1TW	Sinus rhythm disorder	BC9Y	Approved	[107]
Flecainide	DMSQDLE	Tachyarrhythmias	BC71	Approved	[104]
Cisapride	DMY7PED	Gastroesophageal reflux disease	DA22.Z	Approved	[108]
Metoclopramide	DMFA5MY	Nausea	MD90	Approved	[101]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[102]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[103]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[104]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[104]
Disopyramide	DM5SYZP	Long QT syndrome	BC65.0	Approved	[105]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[106]
Dofetilide	DMPN1TW	Sinus rhythm disorder	BC9Y	Approved	[107]
Flecainide	DMSQDLE	Tachyarrhythmias	BC71	Approved	[104]
Cisapride	DMY7PED	Gastroesophageal reflux disease	DA22.Z	Approved	[108]

Drug(s) Affected By Sodium channel protein type 5 subunit alpha (SCN5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Disopyramide	DM5SYZP	Long QT syndrome	BC65.0	Approved	[109]
Flecainide	DMSQDLE	Tachyarrhythmias	BC71	Approved	[110]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[111]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[112]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[114]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Retigabine	DMGNYIH	Behcet disease	4A62	Approved	[117]
Luvox	DMJKROX	Anxiety disorder	6B00-6B0Z	Approved	[118]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[119]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[120]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[122]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Selenium	DM25CGV	N. A.	N. A.	Approved	[124]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[119]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[125]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[126]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[125]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[127]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[128]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[129]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[130]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[131]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[132]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[133]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[134]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[135]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[133]

Drug(s) Affected By Nuclear protein 1 (NUPR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[141]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[15]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[142]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[143]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[15]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[15]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[15]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[145]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[142]

Drug(s) Affected By Serine protease hepsin (HPN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[15]
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[15]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[15]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[15]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[142]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[15]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]

Drug(s) Affected By Fatty acid-binding protein, liver (FABP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[15]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[143]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[15]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[150]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[15]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[15]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[142]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[152]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[153]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[15]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[143]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[15]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[126]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[15]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[15]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[154]

Drug(s) Affected By Lanosterol synthase (LSS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[15]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[155]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[15]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[15]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[15]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[156]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[157]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[142]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[15]

Drug(s) Affected By Inhibin beta E chain (INHBE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[15]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[143]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[15]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[15]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[15]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[157]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[142]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[15]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[158]

Drug(s) Affected By Acid ceramidase (ASAH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[15]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[159]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[142]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[160]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[15]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[142]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[15]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[142]

Drug(s) Affected By Asparagine synthetase (ASNS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[168]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[15]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[169]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[15]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[170]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[171]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[142]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[15]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]

Drug(s) Affected By AP-1 complex subunit sigma-1A (AP1S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[15]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[15]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[142]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[175]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[176]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[143]

Drug(s) Affected By Transgelin (TAGLN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[15]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[178]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[143]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[15]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[179]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[15]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[15]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[143]

Drug(s) Affected By Lysophospholipase D GDPD3 (GDPD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[15]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[143]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[15]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[142]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[142]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[15]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[181]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[182]
Haloperidol	DM96SE0	Delirium		Approved	[142]

Drug(s) Affected By Fibronectin type III domain-containing protein 4 (FNDC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[15]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[15]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[15]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[15]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[142]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[15]
Haloperidol	DM96SE0	Delirium		Approved	[142]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[15]

Drug(s) Affected By Protein DEPP1 (DEPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[15]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[142]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[184]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[15]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[15]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[15]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[142]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[142]

Drug(s) Affected By PLAC8-like protein 1 (PLAC8L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[188]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[190]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[191]

Drug(s) Affected By ADP-ribose glycohydrolase MACROD2 (MACROD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[158]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[193]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[194]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[158]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[196]

Drug(s) Affected By FERM domain-containing protein 3 (FRMD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[197]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[201]

Drug(s) Affected By EF-hand calcium-binding domain-containing protein 5 (EFCAB5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]

Drug(s) Affected By Olfactory receptor 14I1 (OR14I1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]

Drug(s) Affected By Proline-rich protein 19 (PRR19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[204]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]

Drug(s) Affected By ERI1 exoribonuclease 2 (ERI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[209]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
QUERCITRIN	DM1DH96	Discovery agent	N.A.	Investigative	[210]

Drug(s) Affected By PHD finger protein 20-like protein 1 (PHF20L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[211]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[212]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[213]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[158]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[209]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[197]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[213]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[196]

Drug(s) Affected By ATP-dependent RNA helicase DDX39A (DDX39A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[197]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[145]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[182]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[214]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]

Drug(s) Affected By Phospholemman (FXYD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[144]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[148]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[215]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[194]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]

Drug(s) Affected By Activator of apoptosis harakiri (HRK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[216]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[158]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[217]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[196]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[216]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[218]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Methamphetamine	DMPM4SK	Anxiety		Approved	[219]

Drug(s) Affected By 26S proteasome non-ATPase regulatory subunit 11 (PSMD11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[220]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[222]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[196]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[223]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[224]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[225]

Drug(s) Affected By Class E basic helix-loop-helix protein 40 (BHLHE40)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[226]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[227]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[158]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[228]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[229]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]

Drug(s) Affected By Suppressor of cytokine signaling 6 (SOCS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[230]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[231]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[148]

Drug(s) Affected By Acyl-coenzyme A thioesterase 8 (ACOT8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[233]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[233]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[235]

Drug(s) Affected By Free fatty acid receptor 3 (FFAR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]

Drug(s) Affected By Protein lin-7 homolog A (LIN7A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[182]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[236]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[158]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[237]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[188]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[238]

Drug(s) Affected By NEDD4-binding protein 3 (N4BP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[158]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[149]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[239]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[240]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[194]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[158]

Drug(s) Affected By Fanconi anemia group A protein (FANCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[241]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[182]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[214]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[149]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]

Drug(s) Affected By Transcription factor MafG (MAFG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[153]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[243]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[244]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[245]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[246]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]

Drug(s) Affected By Period circadian protein homolog 1 (PER1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[247]
Haloperidol	DM96SE0	Delirium		Approved	[248]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[249]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[250]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[251]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[252]

Drug(s) Affected By Cytochrome P450 26A1 (CYP26A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[253]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[254]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[253]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[255]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[256]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[257]
Dolutegravir	DMCZGRE	Human immunodeficiency virus infection	1C62	Approved	[258]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[253]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[259]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[260]

Drug(s) Affected By Interleukin-1 receptor-associated kinase-like 2 (IRAK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[156]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[261]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[237]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[157]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[262]

Drug(s) Affected By Rho guanine nucleotide exchange factor 9 (ARHGEF9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[197]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[197]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[263]

Drug(s) Affected By Krueppel-like factor 4 (KLF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[168]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[145]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[264]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[265]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[266]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[261]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[267]

Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[268]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[269]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[270]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[271]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[272]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[158]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[273]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[274]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]

Drug(s) Affected By Maleylacetoacetate isomerase (GSTZ1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[159]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[275]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[276]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[229]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[277]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[278]

Drug(s) Affected By Protocadherin-7 (PCDH7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[158]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[261]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[267]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[279]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[280]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[158]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[281]

Drug(s) Affected By Signal-induced proliferation-associated 1-like protein 3 (SIPA1L3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[283]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[201]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[146]

Drug(s) Affected By Cyclin-T1 (CCNT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[284]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[285]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[201]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]

Drug(s) Affected By Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 (HCN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[176]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[194]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[286]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[287]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[288]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[288]

Drug(s) Affected By SH2 domain-containing protein 1A (SH2D1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[289]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[290]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]

Drug(s) Affected By Oligophrenin-1 (OPHN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[182]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[291]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[292]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[293]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[235]

Drug(s) Affected By Checkpoint protein HUS1 (HUS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[276]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[294]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[295]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[283]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[240]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]

Drug(s) Affected By Microphthalmia-associated transcription factor (MITF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[296]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[297]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[298]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[299]
Vemurafenib	DM62UG5	Melanoma	2C30	Approved	[300]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[261]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]

Drug(s) Affected By Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein (NOS1AP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[188]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[239]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[220]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[220]

Drug(s) Affected By Transmembrane and coiled-coil domains protein 2 (TMCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[301]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[302]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[303]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[204]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[302]

Drug(s) Affected By Calcium-responsive transactivator (SS18L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[176]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]

Drug(s) Affected By Low-density lipoprotein receptor-related protein 5 (LRP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[238]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[304]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[305]

Drug(s) Affected By PC4 and SFRS1-interacting protein (PSIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[197]
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[306]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[307]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]

Drug(s) Affected By TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L (TAF5L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[308]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[237]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[309]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[310]

Drug(s) Affected By Polycomb protein EED (EED)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[311]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[312]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[209]
GSK2816126	DMJDVW4	Solid tumour/cancer	2A00-2F9Z	Phase 1	[311]

Drug(s) Affected By Syntaxin-11 (STX11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[313]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[188]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[239]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[314]

Drug(s) Affected By Death effector domain-containing protein (DEDD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[315]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[316]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[291]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[317]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[146]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[225]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[317]

Drug(s) Affected By TOM1-like protein 1 (TOM1L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[158]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[220]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[288]

Drug(s) Affected By Protein phosphatase 1B (PPM1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[276]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[318]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[116]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]

Drug(s) Affected By Serine/threonine-protein kinase 16 (STK16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[319]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[320]

Drug(s) Affected By Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[168]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[321]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[226]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[294]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[181]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[322]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[323]

Drug(s) Affected By Gamma-butyrobetaine dioxygenase (BBOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[324]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[325]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[326]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[324]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[327]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[328]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[329]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[188]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF8 (RNF8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[220]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[220]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[330]

Drug(s) Affected By Cystatin-F (CST7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[150]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[331]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[332]
Bortezomib	DMNO38U	Leukemia		Approved	[333]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[334]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[188]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[335]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[336]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[337]

Drug(s) Affected By Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[213]

Drug(s) Affected By FERM, ARHGEF and pleckstrin domain-containing protein 2 (FARP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[338]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[220]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[339]

Drug(s) Affected By SLIT and NTRK-like protein 3 (SLITRK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[281]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]

Drug(s) Affected By Protein HEXIM1 (HEXIM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[340]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[341]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]

Drug(s) Affected By Semaphorin-3D (SEMA3D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[158]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[212]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[239]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[194]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[286]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[338]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[288]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[197]

Drug(s) Affected By Elongator complex protein 1 (ELP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[216]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[216]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[109]

Drug(s) Affected By Protocadherin-8 (PCDH8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[158]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[292]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[238]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[194]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[158]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[158]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[342]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 gamma (GADD45G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[241]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[343]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[344]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[345]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[182]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[346]
Febuxostat	DMDEXQ0	Hyperuricaemia	5C55.Y	Approved	[347]

Drug(s) Affected By Supervillin (SVIL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[197]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[220]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[348]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[349]
Mestranol	DMG3F94	Contraception	QA21	Approved	[348]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[332]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[327]

Drug(s) Affected By Neuroendocrine secretory protein 55 (GNAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[284]
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[158]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[236]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[346]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[350]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[230]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[351]

Drug(s) Affected By Neuronal pentraxin receptor (NPTXR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[236]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[188]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[194]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[303]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[197]

Drug(s) Affected By T-cell leukemia/lymphoma protein 1B (TCL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[201]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[197]

Drug(s) Affected By Tyrosine-protein kinase ABL1 (ABL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[109]
Anagrelide	DMSQ8MD	Thrombocythemia	3B63	Approved	[109]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[352]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[353]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[354]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[355]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[356]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[321]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[356]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[357]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[284]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[358]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[359]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[360]

Drug(s) Affected By Proenkephalin-B (PDYN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[284]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[158]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[361]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[362]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[363]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[363]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[364]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]

Drug(s) Affected By Interleukin-1 alpha (IL1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[141]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[365]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[365]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[366]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[365]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[150]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[367]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[365]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[368]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]

Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[109]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[369]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[370]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[371]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[372]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[373]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[374]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[375]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[376]

Drug(s) Affected By Semenogelin-1 (SEMG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[377]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[116]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[312]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
Okadaic acid	DM47CO1	Discovery agent	N.A.	Investigative	[378]

Drug(s) Affected By HLA class II histocompatibility antigen, DP beta 1 chain (HLA-DPB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[379]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[276]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[349]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[380]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[381]
Bortezomib	DMNO38U	Leukemia		Approved	[333]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[382]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[116]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[194]

Drug(s) Affected By Metallothionein-1F (MT1F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[141]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[216]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[294]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[383]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[349]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[237]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[384]

Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[385]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[385]
Ergonovine	DM0VEC1	Postpartum haemorrhage	JA43	Approved	[109]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[386]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[387]
Mizolastine	DM1FDN8	Allergic rhinitis	CA08.0	Approved	[388]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[389]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[390]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[391]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[392]

Drug(s) Affected By Phosphoglycerate kinase 2 (PGK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[393]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[393]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[197]

Drug(s) Affected By Acylphosphatase-1 (ACYP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[288]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[144]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]

Drug(s) Affected By Amino acid transporter heavy chain SLC3A2 (SLC3A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[170]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[172]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[394]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[395]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[216]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[395]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[245]

Drug(s) Affected By Nuclear factor 1 C-type (NFIC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[220]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[396]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[340]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[397]

Drug(s) Affected By Alpha-2A adrenergic receptor (ADRA2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[109]
Rilmenidine	DM13PQW	Hypertension	BA00-BA04	Approved	[398]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[276]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[288]
Oxymetazoline	DM8ZXT6	Arrhythmia	BC9Z	Approved	[399]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[236]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Indapamide	DMGN1PW	Edema	MG29	Approved	[400]

Drug(s) Affected By Homeobox protein Hox-C4 (HOXC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[194]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[338]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[401]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[402]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[263]

Drug(s) Affected By Annexin A4 (ANXA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[403]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[176]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[404]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[405]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[318]

Drug(s) Affected By 2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[325]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[406]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[350]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[350]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]

Drug(s) Affected By Histone H2A type 1 (H2AC11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[141]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[276]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[407]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[308]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[237]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]

Drug(s) Affected By Oncomodulin-1 (OCM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[235]

Drug(s) Affected By LIM and senescent cell antigen-like-containing domain protein 3 (LIMS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[306]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[288]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[303]

Drug(s) Affected By Sulfotransferase 1A3 (SULT1A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[188]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[408]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[409]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[410]
Vitamin C	DMXJ7O8	Adenocarcinoma	2D40	Approved	[411]
Benzyl alcohol	DMBVYDI	Head and body lice	1G00.0	Approved	[412]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[413]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[413]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[414]

Drug(s) Affected By Adenosine receptor A3 (ADORA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[415]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[416]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[236]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[417]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[283]
Indomethacin	DMSC4A7	Bursitis		Approved	[418]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[419]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[420]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase F (PTPRF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[416]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[349]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[193]

Drug(s) Affected By Microsomal glutathione S-transferase 1 (MGST1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[421]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[422]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[246]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[423]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[327]

Drug(s) Affected By Chromogranin-A (CHGA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[158]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[346]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[424]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[425]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[426]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[427]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[158]

Drug(s) Affected By Thyroid hormone receptor beta (THRB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[428]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[158]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[429]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[430]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[261]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[431]

Drug(s) Affected By Proto-oncogene DBL (MCF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[157]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[432]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[224]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]

Drug(s) Affected By Interferon regulatory factor 1 (IRF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[344]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[416]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[433]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[323]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[261]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]

Drug(s) Affected By E3 SUMO-protein ligase EGR2 (EGR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[434]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[237]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[333]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]

Drug(s) Affected By Glucose-6-phosphate 1-dehydrogenase (G6PD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[109]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[350]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[435]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[436]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[155]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[437]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[276]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[438]

Drug(s) Affected By Collagen alpha-1(XI) chain (COL11A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[203]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[289]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[256]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[214]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[439]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[440]

Drug(s) Affected By Myosin light chain 4 (MYL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[276]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[441]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[432]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[281]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[116]

Drug(s) Affected By 5-aminolevulinate synthase, non-specific, mitochondrial (ALAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[416]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[276]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[442]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[443]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[444]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[257]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[157]

Drug(s) Affected By Metallothionein-1G (MT1G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[168]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[243]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[216]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[444]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[383]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[384]

Drug(s) Affected By Troponin T, slow skeletal muscle (TNNT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[445]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[203]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[446]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[447]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[446]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]

Drug(s) Affected By Leukemia inhibitory factor (LIF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[141]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[243]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[344]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[145]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[448]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[236]

Drug(s) Affected By Cytotoxic T-lymphocyte protein 4 (CTLA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[449]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[450]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[451]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[452]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[336]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[338]

Drug(s) Affected By Homeobox protein Hox-B6 (HOXB6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[159]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[270]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[453]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[201]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[281]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[194]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[454]

Drug(s) Affected By CCAAT/enhancer-binding protein beta (CEBPB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[141]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[126]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[455]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[456]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[457]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[416]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[395]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[158]

Drug(s) Affected By Early growth response protein 1 (EGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[168]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[243]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[126]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[458]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[368]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[459]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[460]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[461]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[462]

Drug(s) Affected By Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (PDE6G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[168]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[243]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[170]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[301]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[463]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[464]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[216]

Drug(s) Affected By Inter-alpha-trypsin inhibitor heavy chain H2 (ITIH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[465]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[188]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[240]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[286]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[220]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[466]

Drug(s) Affected By Calpain-3 (CAPN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[236]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[158]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[467]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[194]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[204]

Drug(s) Affected By Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[468]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[141]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[469]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[468]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[470]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[304]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[471]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[468]

Drug(s) Affected By Kit ligand (KITLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[241]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[150]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[367]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[158]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[229]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[472]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[261]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[349]

Drug(s) Affected By Lutropin-choriogonadotropic hormone receptor (LHCGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[109]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[109]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
MICROCYSTIN-LR	DMTMLRN	Discovery agent	N.A.	Investigative	[473]

Drug(s) Affected By Paired box protein Pax-3 (PAX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[474]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[475]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[158]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[475]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[475]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[176]
Dabigatran	DMDI6R4	Stroke	8B20	Approved	[475]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[212]
Abacavir	DMMN36E	Human immunodeficiency virus infection	1C62	Approved	[475]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[476]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[168]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[321]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[343]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[477]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[170]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[478]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[461]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[458]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[479]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[480]

Drug(s) Affected By Deoxyribonuclease-1 (DNASE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[150]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[437]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[437]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[313]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[454]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[454]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[481]

Drug(s) Affected By Collagen alpha-2(VIII) chain (COL8A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[437]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[437]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[434]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[437]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[482]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[483]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[194]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[158]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]

Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[109]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[484]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[184]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[485]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[486]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[487]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[488]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[489]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]

Drug(s) Affected By Tyrosine-protein phosphatase non-receptor type 3 (PTPN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[490]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[490]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[237]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[431]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]

Drug(s) Affected By Dual specificity protein phosphatase 1 (DUSP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[141]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[321]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[485]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[491]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[492]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[145]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[228]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[322]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]

Drug(s) Affected By M-phase inducer phosphatase 1 (CDC25A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[241]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[284]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[119]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[493]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[494]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[495]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[496]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[497]

Drug(s) Affected By Guanylate-binding protein 2 (GBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[145]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[181]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[182]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[453]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[237]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[327]

Drug(s) Affected By Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (DUT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[498]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[499]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[182]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[230]

Drug(s) Affected By Guanylate cyclase soluble subunit alpha-2 (GUCY1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[203]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[194]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[500]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[501]

Drug(s) Affected By Mannose-6-phosphate isomerase (MPI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[502]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[188]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[503]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[504]

Drug(s) Affected By Merlin (NF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[284]
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[505]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[506]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[149]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[419]

Drug(s) Affected By Sepiapterin reductase (SPR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[507]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[319]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[312]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[508]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[509]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[510]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[511]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[512]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[513]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[514]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[435]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[365]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[515]

Drug(s) Affected By Basigin (BSG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[516]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[517]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Carfilzomib	DM48K0X	Multiple myeloma	2A83	Approved	[516]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[276]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[518]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[516]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[350]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[168]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[519]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[321]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[122]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[520]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[243]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[521]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[522]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[226]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]

Drug(s) Affected By Myosin-11 (MYH11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[256]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[453]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[214]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[363]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[363]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[523]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]

Drug(s) Affected By Insulin-like growth factor-binding protein complex acid labile subunit (IGFALS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[236]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[313]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[524]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[524]
Cenestin	DMXQS7K	Menopause symptom	GA30.0	Approved	[524]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[194]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]

Drug(s) Affected By Gap junction alpha-5 protein (GJA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[525]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[526]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[194]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[263]

Drug(s) Affected By Transcription factor 7 (TCF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[527]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[528]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[405]
Bortezomib	DMNO38U	Leukemia		Approved	[333]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[529]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[116]

Drug(s) Affected By Activin receptor type-1B (ACVR1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[530]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[328]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[230]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[451]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[230]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]

Drug(s) Affected By Phosphatidylinositol N-acetylglucosaminyltransferase subunit A (PIGA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[148]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[531]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[532]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]

Drug(s) Affected By Growth/differentiation factor 5 (GDF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[533]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[194]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[534]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]

Drug(s) Affected By Cell surface glycoprotein MUC18 (MCAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[535]
Haloperidol	DM96SE0	Delirium		Approved	[350]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[236]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[506]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[214]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]

Drug(s) Affected By Nuclear receptor subfamily 4 group A member 2 (NR4A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[536]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[476]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[288]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[181]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[322]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[256]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[203]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[237]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[537]

Drug(s) Affected By Phosphorylase b kinase regulatory subunit alpha, skeletal muscle isoform (PHKA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[538]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[220]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[263]

Drug(s) Affected By Lys-63-specific deubiquitinase BRCC36 (BRCC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Bortezomib	DMNO38U	Leukemia		Approved	[333]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[341]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[209]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]

Drug(s) Affected By Mannan-binding lectin serine protease 1 (MASP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[405]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[539]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[194]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[540]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[540]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[541]

Drug(s) Affected By Tryptophan 2,3-dioxygenase (TDO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[176]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[237]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[157]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[542]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[148]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[483]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[194]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[543]

Drug(s) Affected By DNA primase large subunit (PRIM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[241]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[214]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[340]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[213]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[209]

Drug(s) Affected By Regulator of G-protein signaling 6 (RGS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[194]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[286]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[197]
Manganese	DMKT129	N. A.	N. A.	Investigative	[544]

Drug(s) Affected By Presenilin-1 (PSEN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[545]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[344]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[546]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[313]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[404]
Bortezomib	DMNO38U	Leukemia		Approved	[333]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[278]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]

Drug(s) Affected By Cytochrome P450 2J2 (CYP2J2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[547]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[548]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[549]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[550]
Nisoldipine	DM7ISKJ	Hypertension	BA00-BA04	Approved	[547]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[547]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[176]
Gemfibrozil	DMD8Q3J	Hyperlipidaemia	5C80	Approved	[551]

Drug(s) Affected By C-C chemokine receptor type 9 (CCR9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[109]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[109]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[338]
QUERCITRIN	DM1DH96	Discovery agent	N.A.	Investigative	[210]

Drug(s) Affected By H(+)/Cl(-) exchange transporter 5 (CLCN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[212]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[327]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[303]

Drug(s) Affected By H(+)/Cl(-) exchange transporter 6 (CLCN6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[552]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[553]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[197]

Drug(s) Affected By Transketolase-like protein 1 (TKTL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[212]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[554]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[116]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[196]

Drug(s) Affected By Protein FosB (FOSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[168]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[416]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[276]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[433]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[322]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[289]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[346]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[555]

Drug(s) Affected By Clathrin heavy chain 2 (CLTCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[239]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[556]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[303]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[209]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[197]

Drug(s) Affected By Sodium/myo-inositol cotransporter (SLC5A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[211]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[394]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[181]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[261]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[557]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[327]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[318]

Drug(s) Affected By Protein HIRA (HIRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[416]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[308]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[558]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[416]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[559]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[220]

Drug(s) Affected By Telomeric repeat-binding factor 1 (TERF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[560]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[561]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[562]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[146]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]

Drug(s) Affected By Eukaryotic translation initiation factor 5 (EIF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[169]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[220]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[498]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[563]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]

Drug(s) Affected By GTP-binding protein GEM (GEM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[150]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[564]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[196]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[237]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[327]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]

Drug(s) Affected By Peregrin (BRPF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[565]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[220]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[220]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[566]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[567]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[141]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[568]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[569]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[570]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[571]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[572]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[573]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[574]

Drug(s) Affected By Cadherin-15 (CDH15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[194]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[287]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[190]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[339]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[500]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[575]
Hexadecanoic acid	DMWUXDZ	Discovery agent	N.A.	Investigative	[576]

Drug(s) Affected By Caveolin-3 (CAV3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[239]
Phenylephrine	DMZHUO5	Allergic rhinitis	CA08.0	Approved	[577]
ANW-32821	DMMJOZD	N. A.	N. A.	Phase 2	[578]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]

Drug(s) Affected By T-box transcription factor TBX4 (TBX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[541]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[541]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[541]
SB-431542	DM0YOXQ	Pulmonary fibrosis	CB03.4	Preclinical	[579]

Drug(s) Affected By Sestrin-2 (SESN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[168]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[580]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[226]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[172]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[395]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[216]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[395]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[407]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]

Drug(s) Affected By Small integral membrane protein 11 (SMIM11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Bortezomib	DMNO38U	Leukemia		Approved	[333]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[144]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[158]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[581]

Drug(s) Affected By Actin-related protein 2/3 complex subunit 4 (ARPC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[329]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[582]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[146]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[148]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[583]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[584]

Drug(s) Affected By Ras-related C3 botulinum toxin substrate 3 (RAC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[585]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[236]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[410]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
Isoflavone	DM7U58J	N. A.	N. A.	Phase 4	[586]

Drug(s) Affected By Lysozyme C (LYZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[160]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[323]
Glibenclamide	DM8JXPZ	Diabetic complication	5A2Y	Approved	[587]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[588]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[589]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]

Drug(s) Affected By Histone H4 (H4C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[141]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[243]
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[170]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[126]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[590]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[294]

Drug(s) Affected By Histone H2B type 1-C/E/F/G/I (H2BC10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[276]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[236]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[176]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[237]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[530]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[439]

Drug(s) Affected By Calcineurin subunit B type 1 (PPP3R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Bortezomib	DMNO38U	Leukemia		Approved	[333]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[591]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[109]
Sirolimus	DMGW1ID	Advanced cancer	2A00-2F9Z	Approved	[109]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[109]
Tacrolimus	DMZ7XNQ	Graft-versus-host disease	4B24	Approved	[109]

Drug(s) Affected By Inward rectifier potassium channel 2 (KCNJ2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[197]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[237]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[446]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[446]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[592]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[239]

Drug(s) Affected By Histone H3.1 (H3C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[141]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[226]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[288]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[407]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[182]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[236]

Drug(s) Affected By Disks large homolog 4 (DLG4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[405]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[239]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[593]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[303]

Drug(s) Affected By UDP-galactose translocator (SLC35A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[126]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[276]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[190]

Drug(s) Affected By Metallothionein-1X (MT1X)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[168]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[243]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[594]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[216]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[294]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[182]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]

Drug(s) Affected By Large ribosomal subunit protein eL42 (RPL36A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[323]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[201]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[393]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[393]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[504]
AHPN	DM8G6O4	Discovery agent	N.A.	Investigative	[595]

Drug(s) Affected By Rho GTPase-activating protein 4 (ARHGAP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[596]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[416]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[416]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[336]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]

Drug(s) Affected By Cyclin-dependent kinase 17 (CDK17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[597]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[220]

Drug(s) Affected By Spectrin beta chain, non-erythrocytic 1 (SPTBN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[598]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[257]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[313]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[318]
Bortezomib	DMNO38U	Leukemia		Approved	[333]

Drug(s) Affected By Transcription factor RelB (RELB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[599]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[321]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[150]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[298]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[216]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[322]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[182]

Drug(s) Affected By Guanylate cyclase soluble subunit beta-1 (GUCY1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[181]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[600]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[227]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[312]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[312]
Glyceryl trinitrate	DMF72W3	N. A.	N. A.	Phase 4	[601]

Drug(s) Affected By AT-rich interactive domain-containing protein 5A (ARID5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[602]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[149]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[239]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[240]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[209]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[204]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[220]

Drug(s) Affected By Keratin, type I cytoskeletal 17 (KRT17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[603]
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[463]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[437]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[437]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[603]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[437]

Drug(s) Affected By Hepatocyte growth factor activator (HGFAC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[284]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]

Drug(s) Affected By Max dimerization protein 1 (MXD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[344]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[604]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[605]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[289]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[497]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[237]

Drug(s) Affected By Neuronal acetylcholine receptor subunit beta-3 (CHRNB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[212]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[419]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[556]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[197]
AM251	DMTAWHL	Discovery agent	N.A.	Investigative	[606]

Drug(s) Affected By Myocyte-specific enhancer factor 2C (MEF2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[289]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[276]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[158]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[349]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[607]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[419]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]

Drug(s) Affected By Sperm-associated antigen 1 (SPAG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[261]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[236]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[332]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]

Drug(s) Affected By Protocadherin-1 (PCDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[416]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[182]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[431]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[223]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[194]

Drug(s) Affected By Schlafen family member 5 (SLFN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[288]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[608]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[327]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[424]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]

Drug(s) Affected By Putative sodium-coupled neutral amino acid transporter 11 (SLC38A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[589]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[148]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[541]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]

Drug(s) Affected By Neuroblast differentiation-associated protein AHNAK (AHNAK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[169]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[220]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[416]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[158]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[182]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[236]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[237]

Drug(s) Affected By Thyrotroph embryonic factor (TEF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[204]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[235]

Drug(s) Affected By Calcium-activated potassium channel subunit alpha-1 (KCNMA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[197]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[340]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[609]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[610]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[193]

Drug(s) Affected By PR domain zinc finger protein 2 (PRDM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[611]
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[416]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Bortezomib	DMNO38U	Leukemia		Approved	[333]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[612]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[502]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]

Drug(s) Affected By Acetyl-CoA carboxylase 1 (ACACA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[613]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[520]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[614]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[114]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[615]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[276]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[616]

Drug(s) Affected By Krueppel-like factor 10 (KLF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[211]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[416]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[157]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[260]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]

Drug(s) Affected By Dehydrogenase/reductase SDR family member 2, mitochondrial (DHRS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[288]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[182]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[237]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PPP2R5C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[230]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[230]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[312]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[617]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[617]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[454]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[618]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[613]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[619]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[160]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[620]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[170]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[344]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]

Drug(s) Affected By Interleukin-10 receptor subunit alpha (IL10RA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[437]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[437]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[237]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[437]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Teriflunomide	DMQ2FKJ	Hyperlipidaemia	5C80	Approved	[621]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[283]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[622]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[194]

Drug(s) Affected By Rho guanine nucleotide exchange factor 7 (ARHGEF7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[237]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[230]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[149]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]

Drug(s) Affected By Dynactin subunit 1 (DCTN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[623]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[624]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[583]

Drug(s) Affected By Metabotropic glutamate receptor 2 (GRM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[193]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[116]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[194]
Methamphetamine	DMPM4SK	Anxiety		Approved	[625]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[626]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]

Drug(s) Affected By Hepatocyte nuclear factor 4-gamma (HNF4G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[286]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[148]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[197]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[237]
uric acid	DMA1MKT	Discovery agent	N.A.	Investigative	[627]

Drug(s) Affected By Plastin-1 (PLS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[349]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[341]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[628]

Drug(s) Affected By DNA replication complex GINS protein PSF1 (GINS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[355]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[276]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[182]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[405]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[214]

Drug(s) Affected By Prostaglandin reductase 1 (PTGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[153]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[629]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[630]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[246]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[349]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]

Drug(s) Affected By Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (HERPUD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[168]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[321]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[631]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[244]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[322]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[608]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Racecadotril	DMFOTZ7	Diarrhea	ME05.1	Approved	[632]

Drug(s) Affected By Platelet-derived growth factor receptor-like protein (PDGFRL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[212]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[327]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[318]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]

Drug(s) Affected By Homeobox protein SIX1 (SIX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[158]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[237]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[116]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[196]
Lithium chloride	DMHYLQ2	Discovery agent	N.A.	Investigative	[349]

Drug(s) Affected By Cystatin-M (CST6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[344]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[145]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[181]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[633]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[236]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[482]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[634]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[116]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[194]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[158]

Drug(s) Affected By Syntaxin-binding protein 2 (STXBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[170]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[556]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[336]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]

Drug(s) Affected By Urea transporter 2 (SLC14A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[229]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[635]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[197]

Drug(s) Affected By NT-3 growth factor receptor (NTRK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[197]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[636]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[261]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[637]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[194]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[543]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[203]

Drug(s) Affected By U11/U12 small nuclear ribonucleoprotein 35 kDa protein (SNRNP35)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[453]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[240]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[146]

Drug(s) Affected By Tafazzin (TAFAZZIN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[278]
Napabucasin	DMDZ6Q3	Colorectal cancer	2B91.Z	Phase 3	[638]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[336]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]

Drug(s) Affected By Drebrin (DBN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[276]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[434]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[236]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[639]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[507]

Drug(s) Affected By Receptor-type tyrosine-protein phosphatase-like N (PTPRN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[416]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[410]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[416]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]

Drug(s) Affected By Tigger transposable element-derived protein 6 (TIGD6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[308]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[209]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]

Drug(s) Affected By Intestine-specific homeobox (ISX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[182]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[148]
OXYQUINOLINE	DMZVS9Y	Discovery agent	N.A.	Investigative	[144]

Drug(s) Affected By Coiled-coil domain-containing protein 96 (CFAP184)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[116]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[500]

Drug(s) Affected By CST complex subunit CTC1 (CTC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[197]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[303]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[237]

Drug(s) Affected By GON-4-like protein (GON4L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[237]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[149]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[224]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[336]

Drug(s) Affected By Probable E3 SUMO-protein ligase RNF212 (RNF212)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[197]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[575]

Drug(s) Affected By Malonate--CoA ligase ACSF3, mitochondrial (ACSF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[197]

Drug(s) Affected By Enhancer of polycomb homolog 2 (EPC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[209]

Drug(s) Affected By Rho GTPase-activating protein 15 (ARHGAP15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[158]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[237]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[283]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[116]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[336]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[337]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[211]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[237]

Drug(s) Affected By Puratrophin-1 (PLEKHG4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[405]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[363]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[283]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[303]

Drug(s) Affected By RUN domain-containing protein 3A (RUNDC3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[176]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[188]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[197]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[213]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[235]

Drug(s) Affected By Putative tripartite motif-containing protein 61 (TRIM61)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]

Drug(s) Affected By Transmembrane protein 31 (TMEM31)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[363]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[363]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[196]

Drug(s) Affected By Kidney mitochondrial carrier protein 1 (SLC25A30)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[349]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[157]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[278]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[280]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[303]

Drug(s) Affected By Clavesin-2 (CLVS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]

Drug(s) Affected By Uncharacterized protein C6orf141 (C6ORF141)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[141]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[158]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[363]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[188]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[239]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[158]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[194]

Drug(s) Affected By DC-STAMP domain-containing protein 2 (DCST2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]

Drug(s) Affected By Late cornified envelope-like proline-rich protein 1 (LELP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[640]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[193]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID27336223-Compound-5	DM6E50A	N. A.	N. A.	Patented	[640]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[235]

Drug(s) Affected By G kinase-anchoring protein 1 (GKAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[158]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Bortezomib	DMNO38U	Leukemia		Approved	[333]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[188]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[239]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]

Drug(s) Affected By Protein SLX4IP (SLX4IP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[209]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[337]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[197]

Drug(s) Affected By MORN repeat-containing protein 5 (MORN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
Fenfluramine	DM0762O	Dravet syndrome	8A61.11	Phase 3	[641]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[575]

Drug(s) Affected By Janus kinase and microtubule-interacting protein 3 (JAKMIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[405]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[602]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[197]

Drug(s) Affected By Protein stum homolog (STUM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[238]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[194]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]

Drug(s) Affected By TBC1 domain family member 3C (TBC1D3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[642]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[146]

Drug(s) Affected By Speckle-type POZ protein-like (SPOPL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[338]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[197]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[235]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[441]

Drug(s) Affected By Tau-tubulin kinase 2 (TTBK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[158]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[447]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[643]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[303]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[158]

Drug(s) Affected By Polypeptide N-acetylgalactosaminyltransferase 17 (GALNT17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[236]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[194]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[203]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[196]

Drug(s) Affected By Mitochondrial adenyl nucleotide antiporter SLC25A25 (SLC25A25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Teriflunomide	DMQ2FKJ	Hyperlipidaemia	5C80	Approved	[644]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[283]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[645]

Drug(s) Affected By N-alpha-acetyltransferase 16, NatA auxiliary subunit (NAA16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[197]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[646]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[158]

Drug(s) Affected By Putative ATP-dependent RNA helicase DHX57 (DHX57)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[346]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[283]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[235]

Drug(s) Affected By Protein C3orf33 (C3ORF33)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[158]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[144]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[647]

Drug(s) Affected By tRNA methyltransferase 10 homolog B (TRMT10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[197]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[158]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[626]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]

Drug(s) Affected By Complexin-2 (CPLX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[431]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[286]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[466]

Drug(s) Affected By Adhesion G-protein coupled receptor D1 (ADGRD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[212]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[194]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]

Drug(s) Affected By POTE ankyrin domain family member H (POTEH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[182]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]

Drug(s) Affected By SLP adapter and CSK-interacting membrane protein (SCIMP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[648]

Drug(s) Affected By Lactase-like protein (LCTL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[158]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[194]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[158]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[158]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[196]

Drug(s) Affected By Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 (ENPP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[649]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[236]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[541]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
lysophosphatidylcholine	DMOGFVH	Discovery agent	N.A.	Investigative	[649]

Drug(s) Affected By ALK and LTK ligand 1 (ALKAL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[214]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[197]

Drug(s) Affected By Protein delta homolog 2 (DLK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[261]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[116]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[204]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[263]

Drug(s) Affected By Vitamin D 25-hydroxylase (CYP2R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[149]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[303]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[235]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[196]

Drug(s) Affected By Neuropeptide S receptor (NPSR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[193]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[197]

Drug(s) Affected By FYVE, RhoGEF and PH domain-containing protein 5 (FGD5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[158]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[236]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[363]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[363]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[158]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[287]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[196]

Drug(s) Affected By Solute carrier organic anion transporter family member 4C1 (SLCO4C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[276]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[158]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[650]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[237]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[327]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[589]

Drug(s) Affected By Putative glycerol kinase 5 (GK5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[261]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[283]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[651]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[237]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[158]

Drug(s) Affected By Mitochondrial S-adenosylmethionine carrier protein (SLC25A26)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[236]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[157]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[197]

Drug(s) Affected By Transmembrane and ubiquitin-like domain-containing protein 2 (TMUB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[239]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[336]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[220]

Drug(s) Affected By Endonuclease/exonuclease/phosphatase family domain-containing protein 1 (EEPD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[261]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[318]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[602]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[283]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]

Drug(s) Affected By Activity-regulated cytoskeleton-associated protein (ARC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[239]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[652]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[541]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[626]

Drug(s) Affected By PHD finger-like domain-containing protein 5A (PHF5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[598]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[653]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[303]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[583]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[235]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[500]
AMINOHIPPURIC ACID	DMUN54G	Discovery agent	N.A.	Investigative	[654]

Drug(s) Affected By Highly divergent homeobox (HDX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[188]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[209]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[204]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]

Drug(s) Affected By LisH domain-containing protein ARMC9 (ARMC9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[229]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[214]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[610]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[637]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[655]

Drug(s) Affected By Transmembrane protease serine 9 (TMPRSS9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[286]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[204]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[500]

Drug(s) Affected By Podocan (PODN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[197]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[214]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[338]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[197]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[656]

Drug(s) Affected By FERM domain-containing protein 5 (FRMD5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[126]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[291]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]

Drug(s) Affected By DnaJ homolog subfamily B member 7 (DNAJB7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[220]

Drug(s) Affected By Large ribosomal subunit protein uL10m (MRPL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[278]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[583]

Drug(s) Affected By Serine/threonine-protein kinase Nek8 (NEK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]

Drug(s) Affected By Telomerase-binding protein EST1A (SMG6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[197]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[146]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[337]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[220]

Drug(s) Affected By Amphoterin-induced protein 1 (AMIGO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[239]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[194]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[303]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[504]

Drug(s) Affected By Proline and serine-rich protein 2 (PROSER2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[182]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[327]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[158]

Drug(s) Affected By Extracellular matrix organizing protein FRAS1 (FRAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[318]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[148]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[220]

Drug(s) Affected By Spermatogenesis-associated protein 2-like protein (SPATA2L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[657]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[213]

Drug(s) Affected By Epidermal growth factor-like protein 6 (EGFL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[288]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[256]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[327]
Indomethacin	DMSC4A7	Bursitis		Approved	[432]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[158]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[281]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[658]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[658]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[658]

Drug(s) Affected By F-box only protein 16 (FBXO16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[239]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[158]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[197]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[659]

Drug(s) Affected By Cadherin-like protein 26 (CDH26)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[181]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[439]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[634]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[235]
2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE	DMNQL17	Discovery agent	N.A.	Investigative	[660]

Drug(s) Affected By MICAL-like protein 2 (MICALL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[283]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[148]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[553]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]

Drug(s) Affected By Dynein regulatory complex subunit 7 (DRC7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[541]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[541]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[541]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[661]

Drug(s) Affected By Collagen alpha-1(XXVII) chain (COL27A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[662]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[303]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]

Drug(s) Affected By Gap junction delta-3 protein (GJD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[194]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]

Drug(s) Affected By Cardiomyopathy-associated protein 5 (CMYA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[194]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]

Drug(s) Affected By T-cell activation inhibitor, mitochondrial (TCAIM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[333]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[213]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[158]

Drug(s) Affected By Thioredoxin domain-containing protein 3 (NME8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[158]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[158]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[158]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[648]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[196]

Drug(s) Affected By Fibrinogen C domain-containing protein 1 (FIBCD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[663]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[158]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[197]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[501]

Drug(s) Affected By Sperm-associated microtubule inner protein 4 (SPMIP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[196]

Drug(s) Affected By Protein SREK1IP1 (SREK1IP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[261]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[591]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[158]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[220]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[237]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[158]

Drug(s) Affected By Dynein axonemal assembly factor 3 (DNAAF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[557]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[188]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[194]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[286]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[541]

Drug(s) Affected By Protein boule-like (BOLL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[664]

Drug(s) Affected By Phospholipid-transporting ATPase IG (ATP11C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[363]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[363]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[201]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[288]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[220]

Drug(s) Affected By Proprotein convertase subtilisin/kexin type 9 (PCSK9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[157]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[288]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[665]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[327]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[666]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[667]

Drug(s) Affected By Trinucleotide repeat-containing gene 6A protein (TNRC6A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[150]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[281]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[597]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[220]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[646]
Manganese	DMKT129	N. A.	N. A.	Investigative	[544]

Drug(s) Affected By Transmembrane protein 161B (TMEM161B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[240]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[146]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]

Drug(s) Affected By Myosin-IIIa (MYO3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]

Drug(s) Affected By Folliculin (FLCN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[668]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[212]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[669]
Bortezomib	DMNO38U	Leukemia		Approved	[333]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[149]

Drug(s) Affected By DNA helicase B (HELB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[355]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[482]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[647]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[338]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[220]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[197]

Drug(s) Affected By Olfactory receptor 9Q2 (OR9Q2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[197]

Drug(s) Affected By Olfactory receptor 6T1 (OR6T1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[287]

Drug(s) Affected By Olfactory receptor 4F5 (OR4F5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[236]

Drug(s) Affected By GTPase RhebL1 (RHEBL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[196]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[237]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[196]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[263]

Drug(s) Affected By Ermin (ERMN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]

Drug(s) Affected By Ras and Rab interactor 3 (RIN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[182]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[201]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[336]

Drug(s) Affected By DEP domain-containing mTOR-interacting protein (DEPTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[197]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[158]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[670]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[327]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[214]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[318]

Drug(s) Affected By Protein cornichon homolog 3 (CNIH3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[236]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[318]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[340]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[426]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[671]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[286]

Drug(s) Affected By Protein FAM81A (FAM81A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[182]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[194]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[338]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[237]

Drug(s) Affected By Ciliary microtubule-associated protein 3 (CIMAP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[236]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[158]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[158]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[204]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[664]

Drug(s) Affected By Caskin-2 (CASKIN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[220]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[188]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]

Drug(s) Affected By Dynein axonemal heavy chain 7 (DNAH7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[212]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[287]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[220]

Drug(s) Affected By Nanos homolog 1 (NANOS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[395]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[158]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[395]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[333]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[318]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]

Drug(s) Affected By Rho GTPase-activating protein 45 (ARHGAP45)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[672]
Acetazolamide	DM1AF5U	Absence epilepsy		Approved	[672]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[416]
Brinzolamide	DMBAPFG	Ocular hypertension	9C61.01	Approved	[672]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Indapamide	DMGN1PW	Edema	MG29	Approved	[672]
Cefepime	DMHVWIK	Bacterial infection	1A00-1C4Z	Approved	[672]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[673]

Drug(s) Affected By Protein TFG (TFG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[433]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[220]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[293]

Drug(s) Affected By Transcription factor AP-2 gamma (TFAP2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[348]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[158]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[348]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[229]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Mestranol	DMG3F94	Contraception	QA21	Approved	[348]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[674]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[348]

Drug(s) Affected By Prospero homeobox protein 1 (PROX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[675]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[453]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[676]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]

Drug(s) Affected By Coronin-2A (CORO2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[158]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[288]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]

Drug(s) Affected By Probable ATP-dependent RNA helicase DDX17 (DDX17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[677]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[323]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[245]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[245]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[453]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]

Drug(s) Affected By Semaphorin-4D (SEMA4D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[211]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[340]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[116]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[235]

Drug(s) Affected By Transcription factor ATOH1 (ATOH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[678]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[286]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[659]

Drug(s) Affected By RNA-binding protein with multiple splicing (RBPMS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[331]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[276]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[236]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[340]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]

Drug(s) Affected By Thymic stromal lymphopoietin (TSLP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[181]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[261]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[679]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[610]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[240]

Drug(s) Affected By Immunoglobulin superfamily member 8 (IGSF8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[349]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[283]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[680]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[643]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[148]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]

Drug(s) Affected By F-box only protein 32 (FBXO32)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[168]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[395]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[261]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[395]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[176]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[214]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]

Drug(s) Affected By Oxysterol-binding protein 2 (OSBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[141]
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[363]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[363]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[558]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[681]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[286]

Drug(s) Affected By Galactose-3-O-sulfotransferase 3 (GAL3ST3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase FKBP10 (FKBP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[276]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[308]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[679]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]

Drug(s) Affected By Engulfment and cell motility protein 3 (ELMO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[682]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]

Drug(s) Affected By ELL-associated factor 2 (EAF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[301]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[683]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[261]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[301]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[405]
Dutasteride	DMQ4TJK	Benign prostatic hyperplasia	GA90	Approved	[683]

Drug(s) Affected By Reticulocalbin-3 (RCN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[605]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[405]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[188]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[583]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[575]

Drug(s) Affected By Ras-related protein Rab-39B (RAB39B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[669]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[194]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[424]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[237]

Drug(s) Affected By RNA-binding protein 33 (RBM33)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[211]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[240]

Drug(s) Affected By CKLF-like MARVEL transmembrane domain-containing protein 7 (CMTM7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[197]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[196]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[201]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[201]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[336]

Drug(s) Affected By Protein FAM89A (FAM89A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[158]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[245]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[245]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[245]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[245]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[245]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]

Drug(s) Affected By Uncharacterized protein C16orf74 (C16ORF74)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[181]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[197]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[684]

Drug(s) Affected By RCC1-like G exchanging factor-like protein (RCC1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[237]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[338]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[235]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[500]
AM251	DMTAWHL	Discovery agent	N.A.	Investigative	[606]
Hexadecanoic acid	DMWUXDZ	Discovery agent	N.A.	Investigative	[685]

Drug(s) Affected By ATP-binding cassette sub-family C member 11 (ABCC11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[197]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[394]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[650]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[686]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[687]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[687]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[686]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[643]

Drug(s) Affected By CUGBP Elav-like family member 6 (CELF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[688]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[405]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[439]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[197]

Drug(s) Affected By Membrane-spanning 4-domains subfamily A member 14 (MS4A14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]

Drug(s) Affected By Melanoma-associated antigen D4 (MAGED4B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[312]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[312]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[312]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[220]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[466]

Drug(s) Affected By PDZ and LIM domain protein 2 (PDLIM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[182]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[640]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[188]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[146]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[336]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID27336223-Compound-5	DM6E50A	N. A.	N. A.	Patented	[640]

Drug(s) Affected By Spermatogenesis-associated protein 17 (SPATA17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[602]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[363]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[309]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[193]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[193]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[664]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[263]

Drug(s) Affected By Kinesin-like protein KIF16B (KIF16B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[146]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[337]

Drug(s) Affected By Fc receptor-like protein 2 (FCRL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[327]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[237]

Drug(s) Affected By Fc receptor-like protein 1 (FCRL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[689]

Drug(s) Affected By Coiled-coil domain-containing protein 17 (CCDC17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[193]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[597]

Drug(s) Affected By FYVE, RhoGEF and PH domain-containing protein 4 (FGD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[355]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[182]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[318]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[602]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]

Drug(s) Affected By DGAT1/2-independent enzyme synthesizing storage lipids (TMEM68)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[287]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[237]

Drug(s) Affected By Fc receptor-like protein 3 (FCRL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[327]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[393]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[338]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[393]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[197]

Drug(s) Affected By CCA tRNA nucleotidyltransferase 1, mitochondrial (TRNT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[430]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[278]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[239]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]

Drug(s) Affected By Sorting nexin-18 (SNX18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[126]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[261]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[410]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[543]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[293]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[158]

Drug(s) Affected By Tribbles homolog 3 (TRIB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[168]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[325]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[395]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[216]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[326]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[395]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[181]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[322]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]

Drug(s) Affected By Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[416]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[690]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[332]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[341]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]

Drug(s) Affected By DNA endonuclease RBBP8 (RBBP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[348]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[348]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[182]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[203]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[237]
Mestranol	DMG3F94	Contraception	QA21	Approved	[348]

Drug(s) Affected By Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[507]
Bortezomib	DMNO38U	Leukemia		Approved	[333]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[539]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[558]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[220]

Drug(s) Affected By Protein arginine N-methyltransferase 1 (PRMT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[691]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[692]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[693]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[694]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]

Drug(s) Affected By BAG family molecular chaperone regulator 1 (BAG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[273]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[181]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[695]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[313]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[696]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[340]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[252]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-6 beta (ATF6B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[126]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[270]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[605]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[697]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[179]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[188]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[209]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[197]

Drug(s) Affected By Growth/differentiation factor 15 (GDF15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[168]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[243]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[119]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[170]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[298]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[698]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[437]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[437]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[699]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[700]

Drug(s) Affected By BTB/POZ domain-containing protein KCTD14 (KCTD14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[626]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]

Drug(s) Affected By Rho GTPase-activating protein 9 (ARHGAP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[363]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[363]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[158]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[336]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[287]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
CHOLINE	DM5D9YK	Insomnia	7A00-7A0Z	Investigative	[701]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[702]

Drug(s) Affected By Protein fuzzy homolog (FUZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[239]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[339]

Drug(s) Affected By Histone H2A.J (H2AJ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[350]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Haloperidol	DM96SE0	Delirium		Approved	[350]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[350]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[350]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[318]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[149]

Drug(s) Affected By Protein crumbs homolog 3 (CRB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[188]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[235]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[263]

Drug(s) Affected By Programmed cell death protein 10 (PDCD10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[433]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[703]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[704]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[705]

Drug(s) Affected By Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[168]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[395]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[158]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[706]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[670]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[608]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[706]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Racecadotril	DMFOTZ7	Diarrhea	ME05.1	Approved	[632]

Drug(s) Affected By Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase (ALG12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[504]

Drug(s) Affected By Kinesin-like protein KIFC1 (KIFC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[226]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[182]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[608]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[707]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]

Drug(s) Affected By Replication initiator 1 (REPIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[439]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[283]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
PHENOL	DM1QSM3	N. A.	N. A.	Phase 2/3	[304]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[204]
Hexadecanoic acid	DMWUXDZ	Discovery agent	N.A.	Investigative	[708]

Drug(s) Affected By FUN14 domain-containing protein 2 (FUNDC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[278]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[193]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[583]

Drug(s) Affected By Tapasin-related protein (TAPBPL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[709]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[188]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[336]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]

Drug(s) Affected By Krueppel-like factor 16 (KLF16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[283]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[502]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[188]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[201]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[503]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[220]

Drug(s) Affected By NF-kappa-B inhibitor zeta (NFKBIZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[141]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[325]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[433]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[261]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[710]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[327]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[363]

Drug(s) Affected By ATP-binding cassette sub-family A member 2 (ABCA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[650]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Bortezomib	DMNO38U	Leukemia		Approved	[333]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[194]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[711]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[711]

Drug(s) Affected By Protein Niban 1 (NIBAN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[712]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[181]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[261]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[608]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[349]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[431]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[327]

Drug(s) Affected By Forkhead box protein P3 (FOXP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[197]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[713]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[156]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[714]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[715]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
GSK618334	DMJPXZ4	Drug abuse	6C4G.1Z	Phase 1	[716]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
Dorsomorphin	DMKYXJW	Discovery agent	N.A.	Investigative	[717]
Mepacrine	DMU8L7C	Discovery agent	N.A.	Investigative	[718]

Drug(s) Affected By Testis-specific gene 10 protein (TSGA10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[403]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[237]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[237]
Manganese	DMKT129	N. A.	N. A.	Investigative	[544]

Drug(s) Affected By Sperm flagellar protein 2 (SPEF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[158]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[659]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[500]

Drug(s) Affected By Olfactory receptor 2B2 (OR2B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]

Drug(s) Affected By Carbohydrate sulfotransferase 6 (CHST6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[276]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[719]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[236]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[318]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[720]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[146]

Drug(s) Affected By Extracellular glycoprotein lacritin (LACRT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]

Drug(s) Affected By Neuroblastoma breakpoint family member 3 (NBPF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[211]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[591]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
crotylaldehyde	DMTWRQI	Discovery agent	N.A.	Investigative	[721]

Drug(s) Affected By Mitochondrial glutamate carrier 2 (SLC25A18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[188]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[197]

Drug(s) Affected By Myosin light chain kinase 2, skeletal/cardiac muscle (MYLK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[303]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[197]

Drug(s) Affected By Olfactory receptor 2D2 (OR2D2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[160]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]

Drug(s) Affected By Caspase recruitment domain-containing protein 9 (CARD9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[313]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[188]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[220]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[190]

Drug(s) Affected By Enhancer of polycomb homolog 1 (EPC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[197]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[172]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[209]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[220]

Drug(s) Affected By Testis-specific Y-encoded-like protein 2 (TSPYL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[527]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[283]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[149]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[209]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]

Drug(s) Affected By Solute carrier organic anion transporter family member 5A1 (SLCO5A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[405]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[188]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[239]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[722]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
3-iodothyronamine	DM3L0F8	Discovery agent	N.A.	Investigative	[723]

Drug(s) Affected By BolA-like protein 2 (BOLA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[327]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
UNC0379	DMD1E4J	Hepatocellular carcinoma	2C12.02	Preclinical	[724]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[197]

Drug(s) Affected By Semaphorin-6B (SEMA6B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[725]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[725]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[405]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[194]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[303]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]

Drug(s) Affected By Ribokinase (RBKS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[276]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[640]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[201]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[628]

Drug(s) Affected By Glutathione S-transferase omega-2 (GSTO2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[363]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[363]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[591]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[116]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[726]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]

Drug(s) Affected By Alpha-1,3/1,6-mannosyltransferase ALG2 (ALG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[498]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[340]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[310]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[503]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[727]

Drug(s) Affected By Ankyrin repeat and SOCS box protein 7 (ASB7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[197]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[235]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[646]

Drug(s) Affected By Coiled-coil domain-containing protein 134 (CCDC134)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[204]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]

Drug(s) Affected By Nucleolar protein 6 (NOL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[283]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[201]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[201]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[504]

Drug(s) Affected By Dedicator of cytokinesis protein 5 (DOCK5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[158]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[261]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[405]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[239]

Drug(s) Affected By Probable ATP-dependent RNA helicase DDX31 (DDX31)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[197]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[239]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[220]

Drug(s) Affected By Metal transporter CNNM2 (CNNM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[214]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[439]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[291]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[283]

Drug(s) Affected By Inositol-pentakisphosphate 2-kinase (IPPK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[239]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[197]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[646]

Drug(s) Affected By Histone-lysine N-methyltransferase EHMT1 (EHMT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[728]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[236]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[149]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[729]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
YM155	DM5Q1W4	Breast cancer	2C60-2C65	Phase 2	[730]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[209]

Drug(s) Affected By Dysbindin domain-containing protein 1 (DBNDD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[148]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[286]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[144]

Drug(s) Affected By EF-hand and coiled-coil domain-containing protein 1 (EFCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[197]

Drug(s) Affected By Potassium channel subfamily K member 12 (KCNK12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[116]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[731]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[732]

Drug(s) Affected By Peptide deformylase, mitochondrial (PDF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[733]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]

Drug(s) Affected By Rho guanine nucleotide exchange factor 10-like protein (ARHGEF10L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[325]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[176]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[116]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]

Drug(s) Affected By 3',5'-cyclic-AMP phosphodiesterase 7B (PDE7B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[734]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[126]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[288]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[346]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[327]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[188]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[735]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]

Drug(s) Affected By Ras-related protein Rab-9B (RAB9B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[212]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]

Drug(s) Affected By 5'(3')-deoxyribonucleotidase, mitochondrial (NT5M)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[405]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[188]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[600]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[736]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]

Drug(s) Affected By CD320 antigen (CD320)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[336]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[204]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[318]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[213]

Drug(s) Affected By G-protein coupled receptor family C group 5 member C (GPRC5C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[236]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[405]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[318]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[283]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[149]

Drug(s) Affected By E3 ubiquitin-protein ligase TRIM36 (TRIM36)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[283]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[310]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[303]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[220]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[220]

Drug(s) Affected By PR domain zinc finger protein 8 (PRDM8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[236]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[281]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[194]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[286]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[204]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]

Drug(s) Affected By CDC42 small effector protein 1 (CDC42SE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[310]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[504]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[196]
Lithium chloride	DMHYLQ2	Discovery agent	N.A.	Investigative	[688]

Drug(s) Affected By Rho GTPase-activating protein 35 (ARHGAP35)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[737]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[738]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[220]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[220]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[739]

Drug(s) Affected By Three-prime repair exonuclease 1 (TREX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[740]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[239]
Fotemustine	DMV62ED	Solid tumour/cancer	2A00-2F9Z	Approved	[740]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[740]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[146]

Drug(s) Affected By BMP-2-inducible protein kinase (BMP2K)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[236]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[453]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Indomethacin	DMSC4A7	Bursitis		Approved	[741]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[341]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[239]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[116]

Drug(s) Affected By StAR-related lipid transfer protein 5 (STARD5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[201]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[626]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]

Drug(s) Affected By PAK4-inhibitor INKA2 (INKA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[245]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[245]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[363]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[742]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[148]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[504]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF146 (RNF146)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[197]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[332]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[283]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[559]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[220]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[646]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF19A (RNF19A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[261]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[236]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[743]

Drug(s) Affected By Trimethyllysine dioxygenase, mitochondrial (TMLHE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[320]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[235]

Drug(s) Affected By FGFR1 oncogene partner 2 (FGFR1OP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[211]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[270]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Bortezomib	DMNO38U	Leukemia		Approved	[333]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]

Drug(s) Affected By Spermine oxidase (SMOX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[348]
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[416]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[348]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[182]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Mestranol	DMG3F94	Contraception	QA21	Approved	[348]

Drug(s) Affected By 3-oxoacyl- synthase, mitochondrial (OXSM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[245]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[257]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[245]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[278]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[116]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[235]

Drug(s) Affected By DNA damage-inducible transcript 4 protein (DDIT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[168]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[160]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[119]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[744]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[745]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[216]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[294]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[407]

Drug(s) Affected By Glucose-fructose oxidoreductase domain-containing protein 1 (GFOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[563]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[239]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[146]

Drug(s) Affected By Kelch-like protein 28 (KLHL28)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[237]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
QUERCITRIN	DM1DH96	Discovery agent	N.A.	Investigative	[210]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[237]

Drug(s) Affected By DnaJ homolog subfamily B member 12 (DNAJB12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[257]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[197]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[500]

Drug(s) Affected By Protein EURL homolog (C21ORF91)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[340]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[239]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[337]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[646]

Drug(s) Affected By Retinol dehydrogenase 8 (RDH8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]

Drug(s) Affected By Taste receptor type 2 member 10 (TAS2R10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[647]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[339]

Drug(s) Affected By Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[746]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[321]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[520]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[520]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[747]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[520]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[748]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[749]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[750]

Drug(s) Affected By Adenosine deaminase 2 (ADA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[276]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[194]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[336]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[597]

Drug(s) Affected By Mediator of RNA polymerase II transcription subunit 11 (MED11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[201]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[235]

Drug(s) Affected By Kallikrein-14 (KLK14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[235]

Drug(s) Affected By Actin-related protein 3B (ACTR3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[149]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[239]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[197]

Drug(s) Affected By Kinesin-like protein KIF17 (KIF17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[286]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]

Drug(s) Affected By Myelin expression factor 2 (MYEF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[236]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[439]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[504]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[237]

Drug(s) Affected By DnaJ homolog subfamily B member 9 (DNAJB9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[168]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[244]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[322]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[168]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[245]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[245]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[608]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[196]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[245]

Drug(s) Affected By DNA polymerase lambda (POLL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[213]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[751]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[220]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[752]
HONOKIOL	DMJWT3X	Discovery agent	N.A.	Investigative	[753]

Drug(s) Affected By Transcription factor 20 (TCF20)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[419]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[582]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[209]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[220]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[293]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[235]

Drug(s) Affected By HMG domain-containing protein 4 (HMGXB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[146]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[209]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[220]

Drug(s) Affected By Protein FAM153A (FAM153A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[361]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[361]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[426]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
Maleic Acid	DM4L0R7	Discovery agent	N.A.	Investigative	[754]

Drug(s) Affected By Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAIAP2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Streptozocin	DMOF7AT	Pancreatic cancer	2C10	Approved	[109]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[288]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[589]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[363]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[363]

Drug(s) Affected By Krueppel-like factor 15 (KLF15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[158]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[346]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[405]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[188]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[116]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[194]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[310]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]

Drug(s) Affected By Death-associated protein kinase 2 (DAPK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[416]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[755]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[182]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[313]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[440]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[756]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]

Drug(s) Affected By CCR4-NOT transcription complex subunit 7 (CNOT7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[680]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[584]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[237]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[196]

Drug(s) Affected By Potassium voltage-gated channel subfamily E regulatory beta subunit 5 (KCNE5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[236]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[116]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]

Drug(s) Affected By Probable E3 ubiquitin-protein ligase MID2 (MID2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[597]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]

Drug(s) Affected By Tubulointerstitial nephritis antigen (TINAG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[261]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[245]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[245]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[327]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[286]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[237]

Drug(s) Affected By SERTA domain-containing protein 3 (SERTAD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[336]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
CH-223191	DMMJZYC	Solid tumour/cancer	2A00-2F9Z	Investigative	[757]

Drug(s) Affected By Uncharacterized protein C3orf18 (C3ORF18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[336]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]

Drug(s) Affected By Protein Z-dependent protease inhibitor (SERPINA10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[148]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[293]

Drug(s) Affected By Solute carrier family 13 member 4 (SLC13A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[758]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[188]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[235]

Drug(s) Affected By Sarcosine dehydrogenase, mitochondrial (SARDH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[689]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[278]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[466]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[659]

Drug(s) Affected By Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A (MGAT4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[323]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[759]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[280]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[116]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[303]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]

Drug(s) Affected By ALK tyrosine kinase receptor (ALK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ceritinib	DMB920Z	Non-small-cell lung cancer	2C25.Y	Approved	[760]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[761]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[762]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[763]
Masoprocol	DMMVNZ0	Prostate cancer	2C82.0	Approved	[762]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[419]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[764]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[765]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[766]

Drug(s) Affected By Calpain-11 (CAPN11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[313]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[363]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[363]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[767]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[582]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[500]

Drug(s) Affected By Protocadherin gamma-C3 (PCDHGC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[159]
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[126]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[410]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[556]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[146]

Drug(s) Affected By Exonuclease 1 (EXO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[241]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[182]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[608]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[237]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[707]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[214]

Drug(s) Affected By Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[545]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[405]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
AMEP	DMFELMQ	Melanoma	2C30	Phase 1	[768]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[769]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[768]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF6 (RNF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[306]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[229]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[212]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]

Drug(s) Affected By Phospholipase A-2-activating protein (PLAA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Bortezomib	DMNO38U	Leukemia		Approved	[333]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[148]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[481]

Drug(s) Affected By Coiled-coil domain-containing protein 9 (CCDC9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[220]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[220]

Drug(s) Affected By Pygopus homolog 1 (PYGO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[239]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[310]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[743]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[288]

Drug(s) Affected By Lethal(3)malignant brain tumor-like protein 1 (L3MBTL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[197]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[591]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[203]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[237]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[158]

Drug(s) Affected By Jerky protein homolog-like (JRKL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[211]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[176]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[220]

Drug(s) Affected By Malignant fibrous histiocytoma-amplified sequence 1 (MFHAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[239]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[194]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[593]

Drug(s) Affected By Tubulin monoglycylase TTLL3 (TTLL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[405]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
PMID28870136-Compound-48	DMPIM9L	N. A.	N. A.	Patented	[211]

Drug(s) Affected By Protocadherin alpha-C2 (PCDHAC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]

Drug(s) Affected By Mitochondrial import inner membrane translocase subunit Tim13 (TIMM13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[276]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[312]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[146]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[225]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[235]

Drug(s) Affected By Transient receptor potential cation channel subfamily V member 2 (TRPV2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[770]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[771]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Tranilast	DME5Y64	Allergic rhinitis	CA08.0	Approved	[772]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[327]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[591]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[281]

Drug(s) Affected By Transcription factor ETV7 (ETV7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[541]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[204]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[235]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[237]

Drug(s) Affected By NAD-dependent protein lipoamidase sirtuin-4, mitochondrial (SIRT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[773]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[363]
Vitamin B3	DMQVRZH	Chronic renal failure	GB61.Z	Approved	[774]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[278]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[197]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[237]

Drug(s) Affected By Proton-coupled zinc antiporter SLC30A1 (SLC30A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[141]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[170]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[712]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[394]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[276]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[216]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[288]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[261]

Drug(s) Affected By Probable ATP-dependent RNA helicase DDX49 (DDX49)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[209]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[195]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[645]

Drug(s) Affected By Dual specificity protein phosphatase 10 (DUSP10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[321]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[492]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[437]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[395]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[437]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[158]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[395]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[322]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[261]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]

Drug(s) Affected By Bile salt export pump (ABCB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[775]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[776]
Glipizide	DMZA5PQ	Diabetic complication	5A2Y	Approved	[776]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[423]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[775]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[776]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[777]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[775]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[778]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[775]

Drug(s) Affected By Stearoyl-CoA desaturase (SCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[155]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[779]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[779]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[150]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[289]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[779]
Fructose	DM43AN2	Vomiting	MD90	Approved	[780]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[416]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[779]

Drug(s) Affected By Acyl-CoA 6-desaturase (FADS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[668]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[781]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[114]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[276]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[327]
Bortezomib	DMNO38U	Leukemia		Approved	[333]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[283]

Drug(s) Affected By Heterogeneous nuclear ribonucleoprotein A1 (HNRNPA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[113]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[182]
Tetracaine	DM9J6C2	Spinal anesthesia	MB40.3	Approved	[782]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[291]

Drug(s) Affected By Liver carboxylesterase 1 (CES1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[783]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[355]
Dextropropoxyphene	DM23HCX	Pain	MG30-MG3Z	Approved	[784]
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[785]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[786]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[787]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[788]

Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[789]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[790]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[791]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[792]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[790]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[790]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[463]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[793]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[792]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[790]

Drug(s) Affected By T-box transcription factor TBX3 (TBX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[308]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[170]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[396]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[308]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[346]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]

Drug(s) Affected By Trans-Golgi network integral membrane protein 2 (TGOLN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[308]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[220]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[308]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[453]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[794]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]

Drug(s) Affected By Pendrin (SLC26A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[650]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[223]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[671]
CHLORIDE	DM1TJXA	Solid tumour/cancer	2A00-2F9Z	Phase 3	[795]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
IODIDE	DM3FZ6P	Discovery agent	N.A.	Investigative	[796]
Formic Acid	DMNFZC6	Discovery agent	N.A.	Investigative	[797]

Drug(s) Affected By Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[746]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[321]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[798]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[520]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[799]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[520]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[748]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[749]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[520]

Drug(s) Affected By Diacylglycerol O-acyltransferase 1 (DGAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[800]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[150]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[801]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[318]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[149]

Drug(s) Affected By Ubiquitin-like modifier-activating enzyme ATG7 (ATG7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[802]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[803]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[804]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[244]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[805]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[806]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[807]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[244]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[808]

Drug(s) Affected By Phospholipid-transporting ATPase ABCA1 (ABCA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[809]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[810]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[668]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[156]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[811]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[812]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[813]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[814]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[815]

Drug(s) Affected By Zinc finger protein SNAI1 (SNAI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[435]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[816]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[817]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[818]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[325]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[819]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[820]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[821]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[822]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[823]
Haloperidol	DM96SE0	Delirium		Approved	[109]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[159]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[824]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[580]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[825]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[826]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[827]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[828]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[829]

Drug(s) Affected By Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[830]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[831]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[832]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[833]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[834]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[835]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[321]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Selenium	DM25CGV	N. A.	N. A.	Approved	[836]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[837]

Drug(s) Affected By Angiotensinogen (AGT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[838]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[839]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Reboxetine	DM26PRD	Depression	6A70-6A7Z	Approved	[840]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[841]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[842]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[843]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[844]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[845]

Drug(s) Affected By Low-density lipoprotein receptor (LDLR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[846]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[243]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[846]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[847]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[848]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[156]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[276]

Drug(s) Affected By Thyrotropin subunit beta (TSHB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[849]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Octreotide	DMHIDCJ	Acromegaly	5A60.0	Approved	[850]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[851]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[852]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[853]
NITRATE	DMVFB93	Discovery agent	N.A.	Investigative	[854]
[3H]cAMP	DMZRQU7	Discovery agent	N.A.	Investigative	[855]

Drug(s) Affected By Thyroglobulin (TG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[856]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[857]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[182]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[858]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[857]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[202]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[859]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[860]
Fructose	DM43AN2	Vomiting	MD90	Approved	[109]
Ketoprofen	DMRKXPT	Bursitis		Approved	[109]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[861]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[862]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[863]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[864]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[865]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[366]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[184]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[866]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[365]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[580]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[365]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[867]
Selenium	DM25CGV	N. A.	N. A.	Approved	[868]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[869]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[870]

Drug(s) Affected By Serotransferrin (TF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[557]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[871]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[872]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[203]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[873]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[874]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[875]

Drug(s) Affected By Ferritin light chain (FTL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[153]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[243]
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[876]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[222]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[246]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[877]

Drug(s) Affected By Metallothionein-2 (MT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[878]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[141]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[243]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[464]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[879]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[368]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[216]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[294]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[498]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[245]

Drug(s) Affected By Catalase (CAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[580]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[880]
Haloperidol	DM96SE0	Delirium		Approved	[109]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[881]
Selenium	DM25CGV	N. A.	N. A.	Approved	[882]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[883]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[884]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[150]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[885]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]

Drug(s) Affected By Apolipoprotein B-100 (APOB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[520]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[520]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[886]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[156]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[520]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[887]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[520]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[888]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[485]
Selenium	DM25CGV	N. A.	N. A.	Approved	[868]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[171]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[889]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[828]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[890]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[289]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[156]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[891]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[145]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[892]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[150]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[893]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[894]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[895]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[896]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[897]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[898]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[899]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[900]

Drug(s) Affected By Metallothionein-1E (MT1E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[168]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[216]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[901]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[384]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[555]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[902]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[903]

Drug(s) Affected By Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[321]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[169]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[911]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[912]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[459]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[748]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[913]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[914]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[171]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[915]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[141]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[916]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[917]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[184]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[366]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[867]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[421]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[171]

Drug(s) Affected By Beta-hexosaminidase subunit alpha (HEXA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[109]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[224]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]
PP-242	DM2348V	Discovery agent	N.A.	Investigative	[918]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[441]

Drug(s) Affected By Thyroid peroxidase (TPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[197]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[919]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[920]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[921]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[856]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[857]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[921]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[236]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[857]

Drug(s) Affected By Glutathione peroxidase 1 (GPX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[477]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Amlexanox	DM0DQM5	Respiratory tract inflammation	CA07	Approved	[922]
Selenium	DM25CGV	N. A.	N. A.	Approved	[923]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[924]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[925]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[368]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[926]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[927]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[928]

Drug(s) Affected By Cathepsin D (CTSD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[929]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[360]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[416]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[930]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[931]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[932]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]

Drug(s) Affected By Beta-2 adrenergic receptor (ADRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salmeterol	DMIEU69	Allergic asthma	CA23.0	Approved	[933]
Bambuterol	DMKLSHF	Asthma	CA23	Approved	[934]
Terbutaline	DMD4381	Asthma	CA23	Approved	[935]
Salbutamol	DMN9CWF	Acute asthma	CA23	Approved	[936]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[937]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[126]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[938]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[939]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[940]

Drug(s) Affected By Procathepsin L (CTSL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[331]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[941]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[942]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[589]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[941]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[334]

Drug(s) Affected By Cathepsin B (CTSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[943]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[159]
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[944]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Pyrimethamine	DM5X7VY	Malaria	1F40-1F45	Approved	[945]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[946]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[856]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[947]

Drug(s) Affected By Beta-1 adrenergic receptor (ADRB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dobutamine	DMD1B8Z	Heart failure	BD10-BD13	Approved	[948]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[949]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[126]
Vortioxetine	DM6F1PU	Major depressive disorder	6A70.3	Approved	[950]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[237]
Labetalol	DMK8U72	Hypertension	BA00-BA04	Approved	[951]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[952]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[953]

Drug(s) Affected By Insulin-like growth factor-binding protein 1 (IGFBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[435]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[954]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[157]
Lisinopril	DMUOK4C	Chronic heart failure	BD1Z	Approved	[955]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[228]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[182]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]

Drug(s) Affected By Glutathione S-transferase A2 (GSTA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[956]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[957]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[150]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[257]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[149]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[671]
Mefenamic acid	DMK7HFI	Dysmenorrhea	GA34.3	Approved	[958]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[959]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[960]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[168]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[916]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[961]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[184]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[485]
Selenium	DM25CGV	N. A.	N. A.	Approved	[962]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[392]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[963]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[344]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[964]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[965]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[966]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[967]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[109]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[141]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[968]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[568]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[862]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[969]

Drug(s) Affected By Thyroid hormone receptor alpha (THRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[332]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[149]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[970]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[240]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[971]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]

Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[545]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[520]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[972]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[973]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[521]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[974]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[975]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[976]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[977]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[614]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[978]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[979]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[350]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[980]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[980]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[394]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[159]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[816]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[981]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[982]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[983]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[984]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[985]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[158]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[917]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[435]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[986]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[366]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[987]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[308]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[392]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[150]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[988]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[989]

Drug(s) Affected By Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (MTHFD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[170]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[395]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[395]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[395]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[349]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]

Drug(s) Affected By Platelet glycoprotein 4 (CD36)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[520]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[990]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[991]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[992]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[993]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[994]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[257]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[995]

Drug(s) Affected By Integrin beta-5 (ITGB5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[284]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[308]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[158]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[308]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[308]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[158]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[327]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[363]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[321]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[122]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[284]
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[170]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[748]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[749]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[244]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[750]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[996]

Drug(s) Affected By Cadherin-2 (CDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[284]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[289]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[428]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[158]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[997]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[998]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[999]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[1000]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[1001]

Drug(s) Affected By Transcription factor EB (TFEB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[1002]
Prochlorperazine	DM53SRA	Nausea	MD90	Approved	[1002]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[805]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[1003]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[236]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[283]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[194]

Drug(s) Affected By Nuclear factor NF-kappa-B p105 subunit (NFKB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[960]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[700]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[321]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[343]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[284]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1004]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[827]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[455]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1005]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[367]

Drug(s) Affected By Interleukin-10 (IL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[389]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[1006]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[1007]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[492]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[713]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1008]
Bisoprolol	DM3UZ95	Hypertension	BA00-BA04	Approved	[1009]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1010]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[1011]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[1012]

Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[1013]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[613]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[802]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1014]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[269]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1015]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[1016]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[416]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[1017]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1018]

Drug(s) Affected By Alanine aminotransferase 1 (GPT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Halothane	DM80OZ5	Anaesthesia	9A78.6	Approved	[109]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[1019]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[1020]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[109]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[109]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[109]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1021]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1022]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[1021]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[1021]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1023]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[1024]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[296]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[862]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[1025]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[1026]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[1027]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1028]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[1029]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[773]

Drug(s) Affected By Calreticulin (CALR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[973]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[683]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[642]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[1030]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[1031]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[350]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1032]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[1024]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[1033]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[1034]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[1035]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1023]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[109]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[121]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[862]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[1025]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[1036]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[1037]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[898]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[969]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1038]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1014]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[1039]
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[372]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[1040]

Drug(s) Affected By Aryl hydrocarbon receptor (AHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[435]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1041]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[1042]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[1043]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1044]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1045]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[1046]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[1047]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1048]

Drug(s) Affected By Sterol regulatory element-binding protein 1 (SREBF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[172]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[109]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[159]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[800]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[155]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1049]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[815]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[511]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1050]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1051]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1052]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[1053]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[1054]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1055]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1056]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[1057]

Drug(s) Affected By Signal transducer and activator of transcription 1-alpha/beta (STAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[169]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1058]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[171]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[455]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1059]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[458]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[693]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[171]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[181]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[642]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[1060]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1061]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[1062]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[895]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[1063]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[1064]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[1065]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[1066]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[1067]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[484]

Drug(s) Affected By Excitatory amino acid transporter 1 (SLC1A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[158]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[198]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[255]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[327]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[318]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[188]

Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[153]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[211]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[155]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1068]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[276]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[216]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[326]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[444]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1069]

Drug(s) Affected By Fatty acid synthase (FASN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[1070]
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[372]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[520]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1071]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1072]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[156]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[437]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[114]

Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[545]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[1073]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1074]
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1075]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1076]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[367]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1077]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[749]

Drug(s) Affected By Type I iodothyronine deiodinase (DIO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[856]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[306]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Ergocalciferol	DMHO0AR	Hypoparathyroidism	5A50	Approved	[1078]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[428]
Masoprocol	DMMVNZ0	Prostate cancer	2C82.0	Approved	[1078]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[589]
Oxytetracycline	DMOVH1M	Actinomycosis		Approved	[1079]

Drug(s) Affected By Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[1080]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[150]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[156]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[294]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1081]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[1082]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[498]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[122]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[159]
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[1083]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1084]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[469]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[368]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[693]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[227]

Drug(s) Affected By Signal transducer and activator of transcription 2 (STAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[642]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[186]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[382]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[239]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[455]

Drug(s) Affected By ATP-citrate synthase (ACLY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[520]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[614]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[157]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[276]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[1085]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[1086]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[332]
OPC-34712	DMHG57U	Major depressive disorder	6A70.3	Approved	[1087]

Drug(s) Affected By 5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[236]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[453]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[349]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[669]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Vitamin B3	DMQVRZH	Chronic renal failure	GB61.Z	Approved	[1088]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[540]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[540]

Drug(s) Affected By Microsomal triglyceride transfer protein large subunit (MTTP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[520]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[520]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[954]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[520]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[520]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[954]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[992]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[848]

Drug(s) Affected By Caspase-7 (CASP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[1089]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[321]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1090]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[1091]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[1092]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[1092]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[344]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[455]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1093]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[1094]

Drug(s) Affected By Hepatocyte nuclear factor 3-alpha (FOXA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[159]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[435]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1095]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1096]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]

Drug(s) Affected By Actin, aortic smooth muscle (ACTA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[375]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[818]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[1097]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1098]
Pirfenidone	DM6VZFQ	Idiopathic pulmonary fibrosis	CB03.4	Approved	[1099]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[182]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[499]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[182]

Drug(s) Affected By Metallothionein-1H (MT1H)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[168]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[243]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[156]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[216]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[444]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[237]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[384]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[318]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[903]

Drug(s) Affected By Pro-neuregulin-1, membrane-bound isoform (NRG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[241]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[197]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[344]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[461]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[158]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[294]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]

Drug(s) Affected By DNA-binding protein inhibitor ID-2 (ID2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[160]
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[308]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1100]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[395]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[216]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[229]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[308]

Drug(s) Affected By Peroxiredoxin-1 (PRDX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1101]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[973]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[344]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[156]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[368]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[422]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[1102]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[1103]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[964]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[484]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[141]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[968]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[159]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[569]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[1104]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[284]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[1105]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[1106]

Drug(s) Affected By Peroxisomal bifunctional enzyme (EHHADH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[150]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[954]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[954]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[1107]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[1108]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[589]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]

Drug(s) Affected By 5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[211]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1109]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[1081]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[1110]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[1111]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[669]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[291]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[340]

Drug(s) Affected By Eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1112]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[1040]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[494]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[693]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1113]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[181]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[1114]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[1115]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[349]

Drug(s) Affected By Metal regulatory transcription factor 1 (MTF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[1031]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[903]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[239]
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[1116]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1117]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[1118]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[189]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[943]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[961]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[321]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[580]
Selenium	DM25CGV	N. A.	N. A.	Approved	[146]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[1119]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1120]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[889]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[1121]

Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[1122]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1123]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[1124]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[1124]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[1125]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[1126]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[1127]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[614]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[668]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[1016]

Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[905]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[243]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[1128]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[252]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[1129]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[1130]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[1131]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[1132]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[1133]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[916]

Drug(s) Affected By Metallothionein-1M (MT1M)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[168]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[464]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[434]
Phenoxybenzamine	DM8KSQH	Malignant essential hypertension	BA00	Approved	[464]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[464]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[318]

Drug(s) Affected By Phospholipase A2 group XV (PLA2G15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[283]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[232]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[234]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[208]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[303]

Drug(s) Affected By Sodium/iodide cotransporter (SLC5A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[856]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[1134]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1135]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1136]
Tazarotene	DM8SMD1	Acne vulgaris	ED80	Approved	[1137]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[1137]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[1137]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[1138]
Romidepsin	DMT5GNL	Cutaneous T-cell lymphoma	2B01	Approved	[1137]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[1137]

Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[571]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[170]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[1139]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[1140]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[463]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[459]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[1141]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[710]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[274]

Drug(s) Affected By Eukaryotic translation initiation factor 2A (EIF2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[122]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[220]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[416]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[1142]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1143]
Cerulenin	DM6N4PR	Weight loss	MG43.5	Approved	[1144]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[498]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[697]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]

Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[613]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[1145]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[344]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1146]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[244]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[1147]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[805]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[1148]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1149]

Drug(s) Affected By Very long chain fatty acid elongase 6 (ELOVL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[156]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[327]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[214]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[318]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[206]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[1150]
Fructose	DM43AN2	Vomiting	MD90	Approved	[780]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[1151]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[1152]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[242]
Ketotifen	DM74XKS	Allergic conjunctivitis	9A60.02	Approved	[954]
Riboflavin	DM8YMWE	Acne vulgaris	ED80	Approved	[1153]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[199]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[1153]

Drug(s) Affected By Peroxisomal carnitine O-octanoyltransferase (CROT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[141]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[954]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[177]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[405]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[187]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[502]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[238]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[203]

Drug(s) Affected By Transcription factor MafF (MAFF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[153]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[435]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[1154]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[156]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[276]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[244]

Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[153]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[365]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[211]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[365]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[365]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[171]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[1155]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[395]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[365]

Drug(s) Affected By Angiopoietin-related protein 3 (ANGPTL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[520]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[520]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[520]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[954]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Allopurinol	DMLPAOB	Gout	FA25	Approved	[520]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[1156]
Indomethacin	DMSC4A7	Bursitis		Approved	[520]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[188]

Drug(s) Affected By Autophagy protein 5 (ATG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[802]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1146]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[805]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[1148]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[1157]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[807]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[1158]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[205]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[964]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[203]

Drug(s) Affected By Cytochrome P450 2A6 (CYP2A6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tegafur	DM31ZQM	Solid tumour/cancer	2A00-2F9Z	Approved	[1159]
Methoxsalen	DME8FZ9	Cutaneous T-cell lymphoma	2B01	Approved	[1160]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[1161]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[1162]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[188]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[29]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[1163]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[257]
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[1164]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[1165]

Drug(s) Affected By Potassium voltage-gated channel subfamily KQT member 1 (KCNQ1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[1166]
Atenolol	DMNKG1Z	Angina pectoris	BA40	Approved	[1166]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[109]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]
Bupivacaine	DM4PRFC	Anaesthesia	9A78.6	Approved	[1167]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Mepivacaine	DMH2NMY	Analgesia	MB40.8	Approved	[1167]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[446]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[446]

Drug(s) Affected By Solute carrier organic anion transporter family member 2B1 (SLCO2B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[394]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[650]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[1168]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[245]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[245]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[116]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1169]

Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[81]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[1170]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[83]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[1171]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[95]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[84]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[164]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[84]
Desipramine	DMT2FDC	Attention deficit hyperactivity disorder	6A05.Z	Approved	[1170]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[109]

Drug(s) Affected By Cytochrome P450 2E1 (CYP2E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fomepizole	DM6VOWQ	Athylene glycol or methanol poisoning	NE61	Approved	[1172]
Ademetionine	DMYQDBO	Hepatic fibrosis	DB93.0	Approved	[1173]
Theophylline	DMRJFN9	Bronchitis	CA20	Approved	[109]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[1174]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[1175]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[188]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[1176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Didanosine	DMI2QPE	Human immunodeficiency virus infection	1C62	Approved	[109]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[1170]

Drug(s) Affected By Cytochrome P450 2B6 (CYP2B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[1171]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[1177]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[1178]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[1179]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[1180]
Clopidogrel	DMOL54H	Acute coronary syndrome	BA41	Approved	[1181]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[1182]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[1183]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[1184]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[1185]

Drug(s) Affected By Cytochrome P450 3A5 (CYP3A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[80]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[81]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[86]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[86]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[1186]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[1187]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[1188]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[183]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[1189]

Drug(s) Affected By Cytochrome P450 3A7 (CYP3A7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[437]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[1187]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[1190]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[720]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[671]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[1191]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[1192]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[1193]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[156]

Drug(s) Affected By Cytochrome P450 2C18 (CYP2C18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[137]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[549]
Lansoprazole	DMXYLQ3	Gastric ulcer	DA60	Approved	[1194]
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[1195]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[197]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[1174]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[148]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[157]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[207]

Drug(s) Affected By Potassium voltage-gated channel subfamily E member 1 (KCNE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Pentobarbital	DMFNH7L	Brain ischaemia	8B1Z	Approved	[1196]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[109]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[109]
Diltiazem	DMAI7ZV	Angina pectoris	BA40	Approved	[109]
Sotalol	DML60TN	Sinus rhythm disorder	BC9Y	Approved	[109]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[109]
Atenolol	DMNKG1Z	Angina pectoris	BA40	Approved	[109]
Procainamide	DMNMXR8	Ventricular arrhythmias	BC71	Approved	[109]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Potassium channel unspecific (KC)	TT1VOHK	NOUNIPROTAC	Modulator	[4]
HUMAN two pore channel subtype 2 (TPC2)	TTHQJ2Y	TPC2_HUMAN	Blocker	[5]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[6]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[7]
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Substrate	[8]
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Substrate	[9]
Cytochrome P450 1A1 (CYP1A1)	DE6OQ3W	CP1A1_HUMAN	Substrate	[10]
Mephenytoin 4-hydroxylase (CYP2C19)	DEGTFWK	CP2CJ_HUMAN	Substrate	[10]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Substrate	[11]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Substrate	[12]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP)	OTB8HCED	CN37_HUMAN	Gene/Protein Processing	[13]
26S proteasome non-ATPase regulatory subunit 11 (PSMD11)	OT8KO67V	PSD11_HUMAN	Gene/Protein Processing	[13]
3',5'-cyclic-AMP phosphodiesterase 7B (PDE7B)	OTK3SHT2	PDE7B_HUMAN	Gene/Protein Processing	[13]
3-oxoacyl- synthase, mitochondrial (OXSM)	OTMDWHOM	OXSM_HUMAN	Gene/Protein Processing	[13]
5'(3')-deoxyribonucleotidase, mitochondrial (NT5M)	OTJF73BA	NT5M_HUMAN	Gene/Protein Processing	[13]
5'-AMP-activated protein kinase catalytic subunit alpha-1 (PRKAA1)	OT7TNF0L	AAPK1_HUMAN	Post-Translational Modifications	[14]
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2)	OTU1KZPV	AAPK2_HUMAN	Post-Translational Modifications	[14]
5-aminolevulinate synthase, non-specific, mitochondrial (ALAS1)	OTQY6ZSF	HEM1_HUMAN	Gene/Protein Processing	[13]
Acetyl-CoA carboxylase 1 (ACACA)	OT5CQPZY	ACACA_HUMAN	Gene/Protein Processing	[13]
Acid ceramidase (ASAH1)	OT1DNGXL	ASAH1_HUMAN	Gene/Protein Processing	[15]

References

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