Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMGU74E)

• Drug Name: Cholecalciferol Drug Info
• Synonyms: Arachitol; Calciol; Cholecalciferolum; Colecalciferol; Colecalciferolo; Colecalciferolum; Colecalcipherol; Delsterol; Deparal; Ebivit; FeraCol; Provitamine; Provitina; Rampage; Ricketon; Trivitan; Vigorsan; Colecalciferolo [DCIT]; VITAMIN D; Duphafral D3 1000; LT00244775; NEO Dohyfral D3; Oleovitamin D3; TNP00266; VITAMIN D3 POWDER; VITAMIN_D3; Vitamin D3; Vitamin D3 emulsifiable; Activated 7-dehydrocholesterol; Cholecalciferol (D3); Cholecalciferol, D3; Colecalciferol (INN); Colecalciferolum [INN-Latin]; D3-Vicotrat; D3-Vigantol; Delta-D; Irradiated 7-dehydrocholesterol; Micro-dee; Vitamin d-3; Cholecalciferol (JP15/USP); Cholecalciferol [USAN:BAN:JAN]; Delta-D (TN); Vitinc Dan-Dee-3; Vi-de-3-hydrosol; (+)-Vitamin D3; (3S,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol; (3beta,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol; (5Z,7E)-(3S)-9,10-seco-5,7,10(19)-cholestatrien-3-ol; (5Z,7E)-(3S)-9,10-secocholesta-5,7,10(19)-trien-3-ol; 25(OH)D; 7-Dehydrocholesterol activated; 7-Dehydrocholesterol, Activated; 7-Dehydrocholesterol, irradiated; 7-Dehydrocholestrol, activated; 9,10-Seco(5Z,7E)-5,7,10(19)-cholestatrien-3-ol; 9,10-Seco(5Z,7E)-5,7,10(19)-cholestatrien-3beta-ol; 9,10-Secocholesta-5(Z),7(E),10(19)-trien-3(beta.)-ol; 9,10-Secocholesta-5,7,10(19)-trien-3-beta-ol

Indication

Disease Entry	ICD 11	Status	REF
Adult acute monocytic leukemia		Approved	[1]
Exostosis		Approved	[1]
Hypercalcaemia	5B91.0	Approved	[1]
Hyperlipidemia	5C80.Z	Approved	[1]
Hypoparathyroidism	5A50	Approved	[1]
Osteoporosis	FB83.0	Approved	[1]
Pleural tuberculosis		Approved	[1]
Primary hyperparathyroidism		Approved	[1]
Rickets	5B57	Approved	[1]
Schizoaffective disorder	6A21	Approved	[1]
Vitamin D deficiency	5B57	Approved	[2]
Vitamin D-dependent rickets		Approved	[1]
Vitamin deficiency	5B55-5B71	Approved	[1]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 3	[3]
Autosomal dominant hypocalcemia	5A50.0Y	Investigative	[1]

• Therapeutic Class: Vitamins
• Cross-matching ID:
  PubChem CID: 5280795
  ChEBI ID: CHEBI:28940
  CAS Number: CAS 67-97-0
  TTD Drug ID: DMGU74E
  ACDINA Drug ID: D00128

Molecule-Related Drug Atlas

Drug(s) Targeting Vitamin D3 receptor (VDR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ergocalciferol	DMHO0AR	Hypoparathyroidism	5A50	Approved	[11]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[12]
Calcidiol	DMN4CV5	Hypophosphatemia		Approved	[11]
Doxercalciferol	DM6FG1P	Chronic kidney disease	GB61	Approved	[13]
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[14]
Falecalcitrol	DMBI9ZJ	Hyperparathyroidism	5A51	Approved	[15]
Dihydrotachysterol	DMFB97P	Hypocalcemia	5B5K.1	Approved	[16]
Paricalcitol	DMYBV3G	Hyperparathyroidism	5A51	Approved	[17]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[18]
S-06911	DMAYTIH	Osteoporosis	FB83.0	Phase 3	[19]

Drug(s) Affected By Cytochrome P450 2B6 (CYP2B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[20]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[21]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[22]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[23]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[24]
Clopidogrel	DMOL54H	Acute coronary syndrome	BA41	Approved	[25]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[26]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[27]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[28]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[29]

Drug(s) Affected By 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[30]
Calcidiol	DMN4CV5	Hypophosphatemia		Approved	[31]
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[32]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[35]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[37]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[38]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]

Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[40]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[41]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[42]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[43]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[44]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[45]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[46]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[47]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[48]

Drug(s) Affected By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[49]
Paliperidone	DM7NPJS	Psychotic disorder	6A20-6A25	Approved	[50]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[51]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[52]
Oxatomide	DM1F42Z	Hay fever	CA08.00	Approved	[53]
Cinacalcet	DMCX0K3	Hyperparathyroidism	5A51	Approved	[54]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[55]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[44]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[56]
Buprenorphine	DMPRI8G	Opioid dependence	6C43.2Z	Approved	[57]

Drug(s) Affected By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[41]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[44]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[43]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[55]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[59]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[44]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[60]
Fluconazole	DMOWZ6B	Cryptococcal meningitis		Approved	[43]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[44]

Drug(s) Affected By Cytidine deaminase (CDA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[61]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[62]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[65]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[66]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[67]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]

Drug(s) Affected By Osteocalcin (BGLAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[70]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[71]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[73]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[74]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[75]
Falecalcitrol	DMBI9ZJ	Hyperparathyroidism	5A51	Approved	[76]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[77]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[78]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[79]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[80]
Fructose	DM43AN2	Vomiting	MD90	Approved	[81]
Ketoprofen	DMRKXPT	Bursitis		Approved	[81]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[82]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[83]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[84]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[85]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[86]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[87]

Drug(s) Affected By Arginase-1 (ARG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[88]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[89]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[91]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[34]

Drug(s) Affected By Nitric oxide synthase, inducible (NOS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Indomethacin	DMSC4A7	Bursitis		Approved	[93]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[94]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[95]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[96]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[97]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[98]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[99]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[100]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[101]

Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[102]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[103]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[104]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[103]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[103]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[106]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[107]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[105]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[103]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[108]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[109]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[110]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[112]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[113]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[96]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]

Drug(s) Affected By Kelch-like ECH-associated protein 1 (KEAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[116]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[33]
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[115]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[118]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[119]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[120]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[122]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[123]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[124]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[125]
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[126]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[127]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[129]

Drug(s) Affected By Toll-like receptor 4 (TLR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[130]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[131]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[132]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[134]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[135]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[136]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[131]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[91]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[119]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 11 (TNFSF11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[137]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[138]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[139]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[140]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[141]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[89]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[142]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[91]

Drug(s) Affected By Phosphatidylinositol 4-phosphate 5-kinase type-1 beta (PIP5K1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[146]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[147]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[148]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[149]

Drug(s) Affected By ATP-binding cassette sub-family C member 4 (ABCC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[150]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[151]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[152]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[153]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[154]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[155]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[157]

Drug(s) Affected By Aquaporin-9 (AQP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[158]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[159]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[160]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[158]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[161]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[162]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[163]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[164]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[159]

Drug(s) Affected By Lymphocyte antigen 75 (LY75)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[140]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[143]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[165]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[166]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[167]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[168]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[140]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[169]
cordycepin	DM72Y01	Discovery agent	N.A.	Investigative	[170]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[171]

Drug(s) Affected By Toll-like receptor 2 (TLR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[172]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[131]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[132]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[173]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[174]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[135]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[131]

Drug(s) Affected By Growth arrest-specific protein 7 (GAS7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[175]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[140]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[67]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[177]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[178]
Bortezomib	DMNO38U	Leukemia		Approved	[179]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[180]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[181]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[182]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[182]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[183]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[184]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[185]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[182]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[182]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[182]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[186]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[187]

Drug(s) Affected By Coagulation factor XIII A chain (F13A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[88]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[189]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[177]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[190]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[191]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[192]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[193]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[189]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[194]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[195]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[124]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[195]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[196]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[197]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[198]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[199]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[200]

Drug(s) Affected By Parathyroid hormone (PTH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[201]
Cinacalcet	DMCX0K3	Hyperparathyroidism	5A51	Approved	[202]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[203]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[181]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[204]
Phosphate	DMUXQG7	Constipation	DD91.1	Approved	[205]
Paricalcitol	DMYBV3G	Hyperparathyroidism	5A51	Approved	[206]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[81]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[81]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[207]

Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[163]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[81]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[208]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[209]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[210]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[211]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[212]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[213]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[214]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[215]

Drug(s) Affected By NADH-ubiquinone oxidoreductase chain 4 (ND4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[216]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[217]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[218]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[190]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[219]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[220]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[221]
CERC-801	DM3SZ7P	N. A.	N. A.	Phase 2	[222]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[223]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[130]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[224]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[225]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[226]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[227]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[228]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[175]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[229]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[230]

Drug(s) Affected By Integrin beta-2 (ITGB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[96]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[231]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[232]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[66]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[189]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[233]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[91]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[234]
Josamycin	DMKJ8LB	Bacterial infection	1A00-1C4Z	Approved	[235]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[172]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[236]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[237]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[238]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[239]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[240]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[87]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[241]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[242]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[172]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[243]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[244]
Fructose	DM43AN2	Vomiting	MD90	Approved	[81]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[245]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[246]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[124]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[247]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[248]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[249]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[250]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[251]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[252]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[253]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[254]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[197]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[255]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[256]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[257]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[258]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[259]

Drug(s) Affected By Annexin A2 (ANXA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[111]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[260]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[261]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[140]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[262]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[263]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[264]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[265]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[39]

Drug(s) Affected By Pulmonary surfactant-associated protein B (SFTPB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[130]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[266]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[144]
Terbutaline	DMD4381	Asthma	CA23	Approved	[267]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[267]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[268]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[269]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[269]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[164]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[164]

Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[270]
Selenium	DM25CGV	N. A.	N. A.	Approved	[271]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[272]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[273]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[274]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[275]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[66]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[276]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[277]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[278]

Drug(s) Affected By Monocyte differentiation antigen CD14 (CD14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[124]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[279]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[280]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[281]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[282]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[283]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[284]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[237]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[285]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[286]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[287]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[288]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[289]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[288]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[290]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[291]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[292]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[293]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[294]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[295]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[296]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[81]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[237]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[297]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[298]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[83]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[299]

Drug(s) Affected By Mast/stem cell growth factor receptor Kit (KIT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[300]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[194]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[301]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[140]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[302]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[165]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[303]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[234]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[304]

Drug(s) Affected By Integrin alpha-M (ITGAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[305]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[232]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[306]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[307]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[308]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[309]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[160]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[310]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[311]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[312]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[313]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[314]
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[315]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[316]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[317]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[318]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[319]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[320]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[321]

Drug(s) Affected By Retinoic acid receptor RXR-alpha (RXRA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[322]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Selenium	DM25CGV	N. A.	N. A.	Approved	[323]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[279]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[324]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[325]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[326]
Acitretin	DM8BKU9	Psoriasis vulgaris	EA90	Approved	[327]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[119]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[328]

Drug(s) Affected By Interleukin-10 (IL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[329]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[330]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[331]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[332]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[333]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[334]
Bisoprolol	DM3UZ95	Hypertension	BA00-BA04	Approved	[335]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[336]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[337]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[338]

Drug(s) Affected By Ribosomal protein S6 kinase beta-1 (RPS6KB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[339]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[109]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[340]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[341]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[255]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[342]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[343]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[232]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[344]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[345]

Drug(s) Affected By G1/S-specific cyclin-E1 (CCNE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[237]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[346]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[347]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[289]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[256]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[348]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[349]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[350]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[351]

Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[352]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[353]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[346]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[354]
Selenium	DM25CGV	N. A.	N. A.	Approved	[355]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[289]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[356]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[357]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[358]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[259]

Drug(s) Affected By DNA cytosine-5)-methyltransferase 1 (DNMT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[359]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[360]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[361]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[362]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[363]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[364]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[365]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[366]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[367]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[368]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[369]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[370]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[371]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[372]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[373]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[374]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[375]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[376]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[194]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[247]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[377]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[254]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[378]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[379]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[380]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[289]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[381]

Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[382]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[108]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[109]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[340]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[383]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[384]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[385]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[386]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[387]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[388]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[389]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[390]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[391]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[226]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[392]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[393]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[394]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[395]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[396]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[397]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[252]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[398]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[380]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[399]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[400]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[401]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[402]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[348]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[403]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[404]

Drug(s) Affected By Solute carrier organic anion transporter family member 1A2 (SLCO1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trospium chloride	DM32XZT	Discovery agent	N.A.	Approved	[405]
Saquinavir	DMG814N	Human immunodeficiency virus infection	1C62	Approved	[406]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[407]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[408]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[68]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[409]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[171]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[410]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[193]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[411]

Drug(s) Affected By NADP-dependent malic enzyme (ME1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[412]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[378]
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[413]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[66]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[414]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[119]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[415]

Drug(s) Affected By Paxillin (PXN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[130]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[416]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[417]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[418]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[419]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[190]
Terbinafine	DMI6HUW	Fungal infection	1F29-1F2F	Approved	[420]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[421]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[422]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[423]
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[424]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[425]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[357]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[99]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[426]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[427]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[428]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[237]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[298]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[429]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[94]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[287]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[430]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[431]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[432]

Drug(s) Affected By Cyclin-dependent kinase 4 inhibitor D (CDKN2D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[197]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[433]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[358]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[115]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[326]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[121]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[434]

Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[175]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[301]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[435]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[130]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[361]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[436]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[437]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[438]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[67]

Drug(s) Affected By Small ribosomal subunit protein eS6 (RPS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[439]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[88]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[440]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[344]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[441]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[442]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[443]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[444]
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[445]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[293]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[397]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[237]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[297]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[423]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[429]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[254]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[197]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[446]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[289]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[175]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[447]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[287]
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[448]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[96]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[449]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[450]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[451]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[99]

Drug(s) Affected By Regulator of G-protein signaling 1 (RGS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[130]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[452]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[177]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[91]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[160]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[453]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[454]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[455]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[456]

Drug(s) Affected By Beclin-1 (BECN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[457]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[237]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[383]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[96]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[458]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[459]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[460]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[461]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[462]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[444]

Drug(s) Affected By Ankyrin repeat domain-containing protein 22 (ANKRD22)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[463]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[78]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[234]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[180]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[464]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[465]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[466]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[301]

Drug(s) Affected By Sodium-independent sulfate anion transporter (SLC26A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[467]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[468]
Bortezomib	DMNO38U	Leukemia		Approved	[179]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[469]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[181]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[470]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[466]

Drug(s) Affected By Extracellular sulfatase Sulf-2 (SULF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[281]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[119]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[39]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[119]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[119]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]

Drug(s) Affected By Mast cell-expressed membrane protein 1 (MCEMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[453]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[180]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[466]

Drug(s) Affected By Leucine-rich repeat-containing protein 25 (LRRC25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[88]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[144]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[221]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[471]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[466]

Drug(s) Affected By Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[88]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[458]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[154]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[472]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[89]
Ceritinib	DMB920Z	Non-small-cell lung cancer	2C25.Y	Approved	[473]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[91]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[190]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[474]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[474]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 14 (SLC2A14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[412]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[467]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[67]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[39]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[144]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[409]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[312]
Vandetanib	DMRICNP	Solid tumour/cancer	2A00-2F9Z	Approved	[475]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[476]

Drug(s) Affected By Bcl2-associated agonist of cell death (BAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[477]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[397]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[478]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[479]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[480]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[481]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[279]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[482]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[141]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[483]

Drug(s) Affected By 5'-3' exonuclease PLD4 (PLD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[91]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[166]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[471]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[466]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[484]

Drug(s) Affected By Proton-coupled folate transporter (SLC46A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[485]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[486]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[487]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Pyrimethamine	DM5X7VY	Malaria	1F40-1F45	Approved	[488]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[489]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[91]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[490]

Drug(s) Affected By Cleavage stimulation factor subunit 2 tau variant (CSTF2T)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[190]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[491]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[469]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[163]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[92]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[149]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[221]

Drug(s) Affected By Membrane-spanning 4-domains subfamily A member 6A (MS4A6A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[189]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[492]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[166]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[493]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[494]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[466]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[484]
taurine	DMVW7N3	Discovery agent	N.A.	Investigative	[495]

Drug(s) Affected By CMRF35-like molecule 8 (CD300A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[232]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[177]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[91]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[468]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[180]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[496]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[493]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[232]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[471]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[466]

Drug(s) Affected By Adhesion G-protein coupled receptor G1 (ADGRG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[34]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[114]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[177]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[144]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[497]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[191]

Drug(s) Affected By RAF proto-oncogene serine/threonine-protein kinase (RAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[498]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[499]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[500]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[501]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[189]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[483]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[367]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[502]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[503]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[504]

Drug(s) Affected By Cytochrome P450 3A5 (CYP3A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[40]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[41]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[46]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[46]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[505]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[408]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[506]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[91]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[507]

Drug(s) Affected By Vitamin D-binding protein (GC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[463]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[264]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[303]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[508]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[509]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[510]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[511]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[465]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[512]

Drug(s) Affected By Fibroblast growth factor 23 (FGF23)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[513]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[514]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[515]
Phosphate	DMUXQG7	Constipation	DD91.1	Approved	[516]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[466]
Glycerol-2-Phosphate	DM0J5KF	Discovery agent	N.A.	Investigative	[516]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[301]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Vitamin D3 receptor (VDR)	TTK59TV	VDR_HUMAN	Binder	[4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial (CYP24A1)	OTG2T749	CP24A_HUMAN	Gene/Protein Processing	[5]
5'-3' exonuclease PLD4 (PLD4)	OT5I74II	PLD4_HUMAN	Gene/Protein Processing	[6]
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[7]
Adhesion G-protein coupled receptor G1 (ADGRG1)	OTQBB8NT	AGRG1_HUMAN	Gene/Protein Processing	[6]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Protein Interaction/Cellular Processes	[8]
Aldo-keto reductase family 1 member C1 (AKR1C1)	OTQKR4CM	AK1C1_HUMAN	Gene/Protein Processing	[9]
Ankyrin repeat domain-containing protein 22 (ANKRD22)	OT6CRQ67	ANR22_HUMAN	Gene/Protein Processing	[6]
Annexin A2 (ANXA2)	OTFNS0CC	ANXA2_HUMAN	Gene/Protein Processing	[6]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[10]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[10]

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