Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMJ2AH4)

Drug Name
Vitamin A Drug Info
Synonyms
Retinol; retinol; all-trans-Retinol; 68-26-8; Vitamin A1; Alphalin; Axerophthol; Afaxin; Oleovitamin A; Chocola A; Ophthalamin; Epiteliol; Biosterol; Aquasynth; Apostavit; Alphasterol; Veroftal; Testavol; Anatola; Prepalin; Myvpack; Agoncal; Agiolan; Vogan; Axerol; Vitpex; Avibon; Apexol; Aoral; Vaflol; Dofsol; Avitol; Vitamin A alcohol; Disatabs Tabs; Lard Factor; Bentavit A; Dohyfral A; all-trans-Retinyl alcohol; Alcovit A; Vogan-Neu; Anatola A; Plivit A; A-Mulsal; Vi-Alpha; A-Vitan; All-trans retinol; Atars; Vafol; trans-retinol; all-trans-Vitamin A; ACON; ATAV; Alin; Avita; Axerophtholum; Cylasphere; LPK; Retinolo; Retinolum; TROL; Thalasphere; Wachstumsvitamin; All Trans Retinol; Antixerophthalmic vitamin; Antixerophthalmisches Vitamin; Aquasol A Parenteral; Homagenets Aoral; Homagenets aorl; Hydrovit A; Mvc Plus; Retinol solution; Retinolo [DCIT]; Retrovitamin A; Sehkraft A; Super A; Testavol S; Vitamin A cryst; Vitamine A; Vitaminum A; Vitavel A; Zinosan N; Rovimix A 500; Vitamin A1 alcohol; A-Sol; Anti-infective vitamin; Beta-Retinol; Retinol [INN:BAN]; Retinolum [INN-Latin]; Solu-A; Trans-Vitamin A alcohol; Trans-retinol; Vi-a; Vi-alpha; Vio-A; Vitamin A (Feed); Vitamin A (USP); Vitamin A alcohol (VAN); Vitamin A1 alcohol, all trans; Vitamin-A; Vitamin-A alcohol; Vitamin-A alcohol solution; Vitamin-A1; Vitavel-A; Vogan-nu; A-Vi-Pel; ALL-TRANS RETINOL (SEE ALSO RETINOID PROJECT 1); All-trans-Retinol; All-trans-Retinyl alcohol; All-trans-Vitamin A; All-trans-Vitamin A alcohol; All-trans-Vitamin A1; Del-VI-A; Hi-A-Vita; Nio-A-Let; Ro-a-vit; Trans-Retinol acid (Vitamin A); Vi-Dom-A; [11,12-3H]-Retinol; MVC 9+3; MVI-12; Retinol, all-trans-(8CI); Retin-11,12-t2-ol (9CI); Retinol-(cellular-retinol-binding-protein); Alcohol 9,13-dimethyl-7-(1,1,5-trimethyl-6-cyclohexen-5-yl)-7,9,11,13-nonatetraen-15-ol; All-trans-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol; (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraen-1-ol; (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraen-1-ol; (all-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol; 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclchexen-1-yl)-2,4,6,8-nonatetraen-1-ol; 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonate-traen-1-ol; 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol; 3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexenyl)-2,4,6,8-nonatetraen-1-ol; 3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol, (all-E)-Isomer; Tricyclics
Indication
Disease Entry ICD 11 Status REF
Night blindness 9D45 Approved [1]
Vitamin A deficiency Approved [2]
Vitamin deficiency 5B55-5B71 Approved [2]
Kinetoplastids 1F61-1G2Z Investigative [3]
Therapeutic Class
Vitamins
Cross-matching ID
PubChem CID
445354
ChEBI ID
CHEBI:17336
CAS Number
CAS 11103-57-4
TTD Drug ID
DMJ2AH4
INTEDE Drug ID
DR1699

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DME
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Retinoic acid receptor (RAR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [23]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [24]
Adapalene DMX2358 Acne vulgaris ED80 Approved [25]
Fenretinide DMRD5SP Macular degeneration 9B78.3 Phase 3 [26]
Peretinoin DMESAZK Hepatocellular carcinoma 2C12.02 Phase 3 [27]
13-cis-retinoic acid DMTZ1A5 Glioma 2A00.0 Phase 3 [28]
Velac Gel DMXHI89 Acne vulgaris ED80 Phase 3 [29]
Amsilarotene DMOB01U Solid tumour/cancer 2A00-2F9Z Phase 2 [30]
LAS-41001 DMXZ4BK Rosacea ED90.0 Discontinued in Preregistration [31]
IRX-4310 DMUYQH8 Psoriasis vulgaris EA90 Discontinued in Phase 3 [32]
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Drug(s) Targeting Retinoic acid receptor RXR-gamma (RXRG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [33]
NRX-4204 DMYXOU2 Diabetic complication 5A2Y Phase 2 [34]
IRX4204 DM9SCME Breast cancer 2C60-2C65 Phase 1 [35]
9cUAB-30 DMYKPXJ Solid tumour/cancer 2A00-2F9Z Phase 1 [36]
SR-11237 DMQG3CK Solid tumour/cancer 2A00-2F9Z Terminated [37]
AGN-34 DM5ECDM Discovery agent N.A. Investigative [38]
LG100754 DMEK4FY Discovery agent N.A. Investigative [39]
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Drug(s) Targeting Trypanosoma Trypanothione reductase (Trypano TPR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bivalirudin DMECRX1 Thrombocytopenia 3B64 Approved [40]
Flavin-Adenine Dinucleotide DM5S4GK Discovery agent N.A. Investigative [41]
CONESSINE DM4VYP0 Discovery agent N.A. Investigative [42]
Maleic Acid DM4L0R7 Discovery agent N.A. Investigative [43]
1-(2'-chlorophenyl)penta-1,4-dien-3-one DMKTZSY Discovery agent N.A. Investigative [44]
CEPHARANTINE DMCE3NA Discovery agent N.A. Investigative [42]
Trypanothione DMDUGQ1 Discovery agent N.A. Investigative [41]
N-(5-chloro-2-(phenylthio)phenyl)butyramide DMHZ256 Discovery agent N.A. Investigative [45]
N1,N2-bis(dihydrocaffeoyl)spermine DMSDVGQ Discovery agent N.A. Investigative [42]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [46]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [47]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [48]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [49]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [50]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [51]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [52]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [53]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [47]
Verapamil DMA7PEW Angina pectoris BA40 Approved [54]
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Drug(s) Metabolized By Cytochrome P450 1A2 (CYP1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [55]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [56]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [57]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [58]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [59]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [60]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [52]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [61]
Verapamil DMA7PEW Angina pectoris BA40 Approved [62]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [63]
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Drug(s) Metabolized By Cytochrome P450 2E1 (CYP2E1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Folic Acid DMEMBJC Colorectal carcinoma Approved [64]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [65]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [66]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [67]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [68]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [61]
Verapamil DMA7PEW Angina pectoris BA40 Approved [69]
Estrone DM5T6US Acne vulgaris ED80 Approved [70]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [71]
Ethanol DMDRQZU Chronic pain MG30 Approved [72]
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Drug(s) Metabolized By Cytochrome P450 2C8 (CYP2C8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [55]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [73]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [73]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [69]
Verapamil DMA7PEW Angina pectoris BA40 Approved [74]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [75]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [76]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [73]
Mycophenolate mofetil DMPQAGE Hepatosplenic T-cell lymphoma Approved [77]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [78]
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Drug(s) Metabolized By Cytochrome P450 1B1 (CYP1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Progesterone DMUY35B Amenorrhea GA20.0 Approved [79]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [80]
Oxaliplatin DMQNWRD Adenocarcinoma 2D40 Approved [61]
Estrone DM5T6US Acne vulgaris ED80 Approved [81]
Erythromycin DM4K7GQ Acne vulgaris ED80 Approved [82]
Rosuvastatin DMMIQ7G Arteriosclerosis BD40 Approved [83]
Caffeine DMKBJWP Allergic rhinitis CA08.0 Approved [84]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [85]
Theophylline DMRJFN9 Bronchitis CA20 Approved [84]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [86]
Flutamide DMK0O7U Prostate cancer 2C82.0 Approved [96]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [97]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [98]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [99]
Estrone DM5T6US Acne vulgaris ED80 Approved [100]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [85]
Amodiaquine DME4RA8 Malaria 1F40-1F45 Approved [101]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [102]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [103]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [104]
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Drug(s) Affected By Cytochrome P450 26A1 (CYP26A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [87]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [88]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [89]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [90]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [91]
Dolutegravir DMCZGRE Human immunodeficiency virus infection 1C62 Approved [92]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [88]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [93]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [94]
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [95]
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Drug(s) Affected By Retinol-binding protein 1 (RBP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [105]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [106]
Panobinostat DM58WKG Chronic graft versus host disease Approved [107]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [108]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [109]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [110]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [111]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [112]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [113]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [114]
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Drug(s) Affected By Homeobox protein Meis1 (MEIS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [105]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [19]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [108]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [109]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [115]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [19]
Arsenic DMTL2Y1 N. A. N. A. Approved [116]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [117]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [118]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [119]
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Drug(s) Affected By Homeobox protein Meis2 (MEIS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [19]
Quercetin DM3NC4M Obesity 5B81 Approved [105]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [19]
Panobinostat DM58WKG Chronic graft versus host disease Approved [120]
Leflunomide DMR8ONJ Arthritis FA20 Approved [121]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [108]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [122]
Ethanol DMDRQZU Chronic pain MG30 Approved [123]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [19]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [113]
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Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [124]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [125]
Diazepam DM08E9O Alcohol withdrawal Approved [126]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [19]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [127]
Methotrexate DM2TEOL Anterior urethra cancer Approved [128]
Ceruletide DM2WE5K Caerulein stimulated gastric and pancreatic secretion 5A4Y Approved [129]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [130]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [131]
Quercetin DM3NC4M Obesity 5B81 Approved [132]
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Drug(s) Affected By Keratin, type I cytoskeletal 18 (KRT18)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [19]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [133]
Selenium DM25CGV N. A. N. A. Approved [134]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [135]
Methotrexate DM2TEOL Anterior urethra cancer Approved [136]
Quercetin DM3NC4M Obesity 5B81 Approved [137]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Panobinostat DM58WKG Chronic graft versus host disease Approved [107]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [139]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [140]
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Drug(s) Affected By Keratin, type II cytoskeletal 8 (KRT8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [19]
Selenium DM25CGV N. A. N. A. Approved [134]
Methotrexate DM2TEOL Anterior urethra cancer Approved [136]
Quercetin DM3NC4M Obesity 5B81 Approved [141]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [19]
Panobinostat DM58WKG Chronic graft versus host disease Approved [107]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [143]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [144]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [122]
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Drug(s) Affected By Involucrin (IVL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcipotriol DM03CP7 Psoriasis EA90 Approved [145]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [146]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [143]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [147]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [145]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [148]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [149]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [150]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [147]
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Drug(s) Affected By Collagen alpha-2(IV) chain (COL4A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [151]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [152]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [151]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [108]
Testosterone enanthate DMB6871 N. A. N. A. Approved [153]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [109]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [154]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [155]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [115]
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Drug(s) Affected By Keratin, type I cytoskeletal 19 (KRT19)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [19]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [156]
Selenium DM25CGV N. A. N. A. Approved [134]
Quercetin DM3NC4M Obesity 5B81 Approved [105]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [157]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [157]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [158]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [159]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [140]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [160]
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Drug(s) Affected By Keratin, type II cytoskeletal 7 (KRT7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [161]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [19]
Selenium DM25CGV N. A. N. A. Approved [134]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [157]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [157]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [143]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [140]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [109]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [149]
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Drug(s) Affected By Retinoic acid receptor alpha (RARA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [19]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [163]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [164]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [160]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [160]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [160]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [160]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [165]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [166]
Ethanol DMDRQZU Chronic pain MG30 Approved [123]
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Drug(s) Affected By Retinoic acid receptor beta (RARB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [19]
Quercetin DM3NC4M Obesity 5B81 Approved [167]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [168]
Panobinostat DM58WKG Chronic graft versus host disease Approved [107]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [169]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [109]
Ethanol DMDRQZU Chronic pain MG30 Approved [123]
Folic Acid DMEMBJC Colorectal carcinoma Approved [170]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [171]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [115]
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Drug(s) Affected By Cadherin-1 (CDH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [19]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [172]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [173]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [174]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [175]
Quercetin DM3NC4M Obesity 5B81 Approved [105]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [176]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [177]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [178]
Panobinostat DM58WKG Chronic graft versus host disease Approved [107]
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Drug(s) Affected By Protein-glutamine gamma-glutamyltransferase 2 (TGM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [19]
Etretinate DM2CZFA Keratosis ED56 Approved [179]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [180]
Testosterone DM7HUNW Hot flushes GA30 Approved [181]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [181]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [182]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [109]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [154]
Ethanol DMDRQZU Chronic pain MG30 Approved [183]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [110]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [19]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [97]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [184]
Methotrexate DM2TEOL Anterior urethra cancer Approved [185]
Epinephrine DM3KJBC Acute asthma CA23 Approved [186]
Quercetin DM3NC4M Obesity 5B81 Approved [187]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [188]
Fructose DM43AN2 Vomiting MD90 Approved [189]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [19]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [190]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Retinoic acid receptor responder protein 1 (RARRES1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [19]
Methotrexate DM2TEOL Anterior urethra cancer Approved [191]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [19]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [192]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [193]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [122]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [19]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [194]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [191]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [195]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Homeobox protein MOX-1 (MEOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [196]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [196]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [196]
Panobinostat DM58WKG Chronic graft versus host disease Approved [107]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [158]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [196]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [197]
Nilotinib DM7HXWT Chronic myelogenous leukaemia 2A20.0 Approved [196]
Ramelteon DM7IW9J Insomnia 7A00-7A0Z Approved [196]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hepatocyte nuclear factor 3-alpha (FOXA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [19]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [163]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [198]
Quercetin DM3NC4M Obesity 5B81 Approved [105]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [199]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [19]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [200]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [197]
Leflunomide DMR8ONJ Arthritis FA20 Approved [121]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [108]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Oxidized low-density lipoprotein receptor 1 (OLR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [19]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [19]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [201]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [202]
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [203]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [110]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [204]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [19]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [205]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [206]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mucin-5AC (MUC5AC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [19]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [207]
Selenium DM25CGV N. A. N. A. Approved [208]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [19]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [209]
Capsaicin DMGMF6V Back pain ME84.Z Approved [210]
Dihydroxyacetone DMM1LG2 Sunburn EJ40 Approved [211]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [19]
Bleomycin DMNER5S Cervical cancer 2C77.0 Approved [212]
Arsenic DMTL2Y1 N. A. N. A. Approved [213]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [214]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [19]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [215]
Methotrexate DM2TEOL Anterior urethra cancer Approved [216]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [217]
Quercetin DM3NC4M Obesity 5B81 Approved [187]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [218]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [19]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [219]
Ethacrynic acid DM60QMR Edema MG29 Approved [220]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription factor GATA-6 (GATA6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [19]
Quercetin DM3NC4M Obesity 5B81 Approved [105]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [19]
Testosterone DM7HUNW Hot flushes GA30 Approved [221]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [105]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [222]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [19]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [223]
Indomethacin DMSC4A7 Bursitis Approved [224]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [198]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Phospholipase A and acyltransferase 4 (PLAAT4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [225]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [159]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [226]
Testosterone DM7HUNW Hot flushes GA30 Approved [181]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [181]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [108]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [109]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [149]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [115]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [227]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Toll-like receptor 4 (TLR4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [228]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [229]
Quercetin DM3NC4M Obesity 5B81 Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [231]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [197]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [233]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [229]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [109]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [160]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transmembrane protease serine 2 (TMPRSS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [16]
Diazepam DM08E9O Alcohol withdrawal Approved [16]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [198]
Selenium DM25CGV N. A. N. A. Approved [134]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [16]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [16]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [16]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [16]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [16]
Fluphenazine DMIT8LX Psychotic disorder 6A20-6A25 Approved [16]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Toll-like receptor 2 (TLR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [191]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [229]
Quercetin DM3NC4M Obesity 5B81 Approved [230]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [191]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [234]
Tibolone DM78XFG Anabolic metabolism 5C50-5C8Z Approved [235]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [232]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [108]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [229]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Myc proto-oncogene protein (MYC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [236]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [237]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [238]
Gefitinib DM15F0X Colon adenocarcinoma Approved [239]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [240]
Selenium DM25CGV N. A. N. A. Approved [241]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [242]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [243]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [244]
Methotrexate DM2TEOL Anterior urethra cancer Approved [228]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Erythropoietin (EPO)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [245]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [246]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [247]
Quercetin DM3NC4M Obesity 5B81 Approved [105]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [108]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [248]
Fenoterol DMIP3ZV Asthma CA23 Approved [249]
Enalapril DMNFUZR Congestive heart failure BD10 Approved [250]
Hydroxyurea DMOQVU9 Chronic myelogenous leukaemia 2A20.0 Approved [251]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [113]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fibronectin (FN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [252]
Methotrexate DM2TEOL Anterior urethra cancer Approved [228]
Quercetin DM3NC4M Obesity 5B81 Approved [167]
Aripiprazole DM3NUMH Bipolar I disorder Approved [253]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [254]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [255]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [152]
Ethacrynic acid DM60QMR Edema MG29 Approved [256]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [257]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [258]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Retinol-binding protein 4 (RBP4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [105]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [17]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [108]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [109]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [259]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [113]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [260]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [223]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [261]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [262]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Albumin (ALB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [263]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [124]
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [264]
Diazepam DM08E9O Alcohol withdrawal Approved [265]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [266]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [267]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [268]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [269]
Methotrexate DM2TEOL Anterior urethra cancer Approved [270]
Quercetin DM3NC4M Obesity 5B81 Approved [271]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transferrin receptor protein 1 (TFRC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [272]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [273]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [229]
Quercetin DM3NC4M Obesity 5B81 Approved [274]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [275]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [276]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [152]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [277]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [278]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [279]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apolipoprotein D (APOD)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [280]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [157]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [109]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [149]
Paclitaxel DMLB81S Breast carcinoma Approved [281]
Chloroquine DMSI5CB Malaria 1F40-1F45 Approved [282]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [223]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [280]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [283]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [119]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Integrin beta-1 (ITGB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [284]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [19]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [272]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [285]
Methotrexate DM2TEOL Anterior urethra cancer Approved [286]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [287]
Fructose DM43AN2 Vomiting MD90 Approved [189]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [177]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [178]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [288]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Monocyte differentiation antigen CD14 (CD14)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [237]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [289]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [142]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [290]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [291]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [292]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [293]
Testosterone DM7HUNW Hot flushes GA30 Approved [181]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [294]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [108]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transforming growth factor beta-3 proprotein (TGFB3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Diazepam DM08E9O Alcohol withdrawal Approved [126]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [163]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [198]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [289]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [295]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [296]
Testosterone DM7HUNW Hot flushes GA30 Approved [181]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [297]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [181]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C motif chemokine 2 (CCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [298]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [163]
Gefitinib DM15F0X Colon adenocarcinoma Approved [299]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [300]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [301]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [302]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [303]
Methotrexate DM2TEOL Anterior urethra cancer Approved [228]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [304]
Quercetin DM3NC4M Obesity 5B81 Approved [305]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclic AMP-responsive element-binding protein 1 (CREB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aspirin DM672AH Acute coronary syndrome BA41 Approved [306]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [307]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [308]
Selenium DM25CGV N. A. N. A. Approved [134]
Methotrexate DM2TEOL Anterior urethra cancer Approved [286]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [254]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [309]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [309]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [310]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [311]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Retinoic acid receptor RXR-alpha (RXRA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [312]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [198]
Selenium DM25CGV N. A. N. A. Approved [313]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [289]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [314]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [315]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [316]
Acitretin DM8BKU9 Psoriasis vulgaris EA90 Approved [317]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [160]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [318]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [319]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [320]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [321]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [322]
Gefitinib DM15F0X Colon adenocarcinoma Approved [323]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [324]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [325]
Selenium DM25CGV N. A. N. A. Approved [134]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [242]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [326]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Integrin alpha-3 (ITGA3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [285]
Selenium DM25CGV N. A. N. A. Approved [134]
Methotrexate DM2TEOL Anterior urethra cancer Approved [327]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [142]
Testosterone DM7HUNW Hot flushes GA30 Approved [181]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [181]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [108]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [109]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [154]
Folic Acid DMEMBJC Colorectal carcinoma Approved [328]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Gamma-aminobutyric acid receptor subunit beta-3 (GABRB3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [231]
Panobinostat DM58WKG Chronic graft versus host disease Approved [107]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [158]
Testosterone DM7HUNW Hot flushes GA30 Approved [221]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [329]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [109]
Flunitrazepam DMGR5Z3 Insomnia 7A00-7A0Z Approved [330]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [113]
Flumazenil DMPCG2L Benzodiazepine overdose PC91 Approved [331]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [332]
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Drug(s) Affected By Cellular retinoic acid-binding protein 2 (CRABP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [333]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [334]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [333]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [168]
Panobinostat DM58WKG Chronic graft versus host disease Approved [107]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [197]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [109]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [115]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [227]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Catenin beta-1 (CTNNB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [335]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [285]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [336]
Quercetin DM3NC4M Obesity 5B81 Approved [187]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [337]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [338]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [339]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [340]
Testosterone DM7HUNW Hot flushes GA30 Approved [341]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [342]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By TGF-beta receptor type-1 (TGFBR1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [343]
Diazepam DM08E9O Alcohol withdrawal Approved [126]
Quercetin DM3NC4M Obesity 5B81 Approved [344]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [289]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [345]
Lenalidomide DM6Q7U4 Adult T-cell leukemia/lymphoma Approved [346]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [346]
Testosterone DM7HUNW Hot flushes GA30 Approved [221]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [347]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [122]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By TGF-beta receptor type-2 (TGFBR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Diazepam DM08E9O Alcohol withdrawal Approved [126]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [198]
Methotrexate DM2TEOL Anterior urethra cancer Approved [286]
Quercetin DM3NC4M Obesity 5B81 Approved [348]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [349]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [152]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [288]
Testosterone DM7HUNW Hot flushes GA30 Approved [181]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [181]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Prostaglandin-H2 D-isomerase (PTGDS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [156]
Selenium DM25CGV N. A. N. A. Approved [134]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [152]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [140]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [109]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [350]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [119]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [351]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [352]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [353]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [354]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [355]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [356]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [357]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [358]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [359]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [360]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [361]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [362]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Excitatory amino acid transporter 2 (SLC1A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [363]
Quercetin DM3NC4M Obesity 5B81 Approved [105]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [231]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [364]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [365]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [347]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [109]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [154]
Thiamphenicol DMDRKH2 Bacterial infection 1A00-1C4Z Approved [366]
Ampicillin DMHWE7P Acute epiglottitis Approved [363]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein Tob1 (TOB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [133]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [367]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [368]
Leflunomide DMR8ONJ Arthritis FA20 Approved [121]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [108]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [369]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [370]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [115]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [371]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-2 (IL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sirolimus DMGW1ID Advanced cancer 2A00-2F9Z Approved [124]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [301]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [372]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [373]
Methotrexate DM2TEOL Anterior urethra cancer Approved [374]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [375]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [376]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [377]
Fentanyl DM8WAHT Analgesia MB40.8 Approved [378]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [379]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Protein BTG2 (BTG2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [97]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [380]
Quercetin DM3NC4M Obesity 5B81 Approved [105]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [225]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [381]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [382]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [383]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [384]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [385]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [226]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Proheparin-binding EGF-like growth factor (HBEGF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [386]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [387]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [388]
Quercetin DM3NC4M Obesity 5B81 Approved [105]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [157]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [157]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [389]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [159]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [197]
Testosterone DM7HUNW Hot flushes GA30 Approved [181]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Angiotensin-converting enzyme 2 (ACE2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Captopril DM458UM Chronic heart failure BD1Z Approved [390]
Diazepam DM08E9O Alcohol withdrawal Approved [16]
Dantrolene DM1D8XY Hyperthermia MG26 Approved [16]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [16]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [16]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [16]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [16]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [16]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [16]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [16]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Receptor for retinol uptake STRA6 (STRA6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [231]
Panobinostat DM58WKG Chronic graft versus host disease Approved [107]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [291]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [122]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [115]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [118]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [107]
Malathion DMXZ84M Pediculus capitis infestation 1G00.0 Approved [391]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [391]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [107]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Epidermal retinol dehydrogenase 2 (SDR16C5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [392]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [202]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [108]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [393]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [113]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [117]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [394]
Milchsaure DM462BT Pruritus EC90 Investigative [395]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [393]
Nicotinamide-Adenine-Dinucleotide DM9LRKB N. A. N. A. Investigative [396]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Retinol dehydrogenase 12 (RDH12)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [133]
Quercetin DM3NC4M Obesity 5B81 Approved [105]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [159]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [108]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [109]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [227]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [113]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [394]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [133]
all-trans-retinal DM6CEVB Discovery agent N.A. Investigative [397]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Retinoid isomerohydrolase (RPE65)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [398]
Arsenic DMTL2Y1 N. A. N. A. Approved [213]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [399]
all-trans-retinal DM6CEVB Discovery agent N.A. Investigative [400]
Drug(s) Affected By Aldo-keto reductase family 1 member B10 (AKR1B10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [401]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [402]
Quercetin DM3NC4M Obesity 5B81 Approved [105]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [349]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [403]
Isoniazid DM5JVS3 Latent tuberculosis infection Approved [404]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [159]
Reserpine DM6VM38 Hypertension BA00-BA04 Approved [405]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [162]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [406]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aldo-keto reductase family 1 member B1 (AKR1B1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [105]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [138]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [365]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [407]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [347]
Disulfiram DMCL2OK Alcohol dependence 6C40.2 Approved [406]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [109]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [154]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [408]
Benzoic Acid DMKB9FI Alopecia areata ED70.2 Approved [406]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Retinoic acid receptor (RAR) TTOD7B3 NOUNIPROTAC Binder [4]
Retinoic acid receptor RXR-gamma (RXRG) TTH029C RXRG_HUMAN Binder [4]
Trypanosoma Trypanothione reductase (Trypano TPR) TTRTKPV TYTR_TRYBB Binder [3]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [5]
Cytochrome P450 2E1 (CYP2E1) DEVDYN7 CP2E1_HUMAN Substrate [6]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Substrate [7]
Cytochrome P450 1B1 (CYP1B1) DE9QHP6 CP1B1_HUMAN Substrate [8]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Substrate [9]
Retinoic acid 4-hydroxylase 26A1 (CYP26A1) DEOVJF2 CP26A_HUMAN Substrate [10]
Retinal dehydrogenase 2 (ALDH1A2) DEKN1H4 AL1A2_HUMAN Substrate [11]
Retinol dehydrogenase 5 (RDH5) DESI4OK RDH5_HUMAN Substrate [12]
Cytochrome P450 2S1 (CYP2S1) DE6NMGO CP2S1_HUMAN Substrate [13]
Short-chain dehydrogenase/reductase retSDR8 (DHRS9) DEGTU5I DHRS9_HUMAN Substrate [11]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Albumin (ALB) OTVMM513 ALBU_HUMAN Protein Interaction/Cellular Processes [14]
Aldo-keto reductase family 1 member B1 (AKR1B1) OTRX72TH ALDR_HUMAN Drug Response [15]
Aldo-keto reductase family 1 member B10 (AKR1B10) OTOA4HTH AK1BA_HUMAN Drug Response [15]
Angiotensin-converting enzyme 2 (ACE2) OTTRZGU7 ACE2_HUMAN Gene/Protein Processing [16]
Apolipoprotein D (APOD) OTT77XW8 APOD_HUMAN Protein Interaction/Cellular Processes [17]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Gene/Protein Processing [18]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Gene/Protein Processing [19]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Gene/Protein Processing [20]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Gene/Protein Processing [21]
Cellular retinoic acid-binding protein 2 (CRABP2) OTY01V9G RABP2_HUMAN Gene/Protein Processing [22]

References

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49 Isoform-specific regulation of cytochromes P450 expression by estradiol and progesterone. Drug Metab Dispos. 2013 Feb;41(2):263-9.
50 Metabolic interactions between acetaminophen (paracetamol) and two flavonoids, luteolin and quercetin, through in-vitro inhibition studies. J Pharm Pharmacol. 2017 Dec;69(12):1762-1772.
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