Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZ7XNQ)

Drug Name
Tacrolimus Drug Info
Synonyms
Advagraf; Fujimycin; Graceptor; Modigraf; Prograf; Protopic; Protopy; Tacarolimus; Tsukubaenolide; Tacrolimus anhydrous; FK 506; FK5; FK506; FR 900506; FR900506; K506; L 679934; Advagraf (TN); FR-900506; Fk-506; L-679934; LCP-Tacro; Prograf (TN); Protopic (TN); Tacrolimus (INN); Tacrolimus (Prograf); Tacrolimus (anhydrous); (-)-FK 506; 15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(23H)-tetrone; 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN
Indication
Disease Entry ICD 11 Status REF
Graft-versus-host disease 4B24 Approved [1]
Hepatosplenic T-cell lymphoma Approved [1]
Kidney transplant rejection NE84 Approved [1]
Large granular lymphocytic leukemia 2A90.1 Approved [1]
Leukemia Approved [1]
Lupus nephritis 4A40.0Y Approved [1]
MALT lymphoma Approved [1]
Myeloproliferative neoplasm 2A20 Approved [1]
Nodal marginal zone lymphoma 2A85.0 Approved [1]
Organ transplant rejection NE84 Approved [2]
Primary cutaneous peripheral T-cell lymphoma not otherwise specified Approved [1]
Recurrent adult burkitt lymphoma 2A85.6 Approved [1]
Small intestine lymphoma Approved [1]
Splenic marginal zone lymphoma Approved [1]
Testicular lymphoma Approved [1]
Ocular allergy 4A81 Phase 3 [2]
Classic Hodgkin lymphoma Investigative [1]
Therapeutic Class
Immunosuppressive Agents
Cross-matching ID
PubChem CID
445643
ChEBI ID
CHEBI:61049
CAS Number
CAS 104987-11-3
TTD Drug ID
DMZ7XNQ
VARIDT Drug ID
DR00406
INTEDE Drug ID
DR1524
ACDINA Drug ID
D00648

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Approved Drug(s)
Investigative Drug(s)
Clinical Trial Drug(s)
Patented Agent(s)
Download the Complete Related Drug List
Drug(s) Targeting Calcineurin (PPP3CA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [17]
Pimecrolimus DMZLGRB Atopic dermatitis EA80 Approved [18]
Voclosporin DMWIJTN Lupus nephritis 4A40.0Y Approved [19]
L-685,818 DMJUQT1 Discovery agent N.A. Investigative [20]
Drug(s) Transported By P-glycoprotein 1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amoxicillin DMUYNEI Acute otitis media AB00 Approved [21]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [22]
Methotrexate DM2TEOL Anterior urethra cancer Approved [4]
Folic Acid DMEMBJC Colorectal carcinoma Approved [23]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [4]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [4]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [24]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [4]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [25]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [26]
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Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [27]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [28]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [29]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [30]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [31]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [32]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [33]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [34]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [28]
Verapamil DMA7PEW Angina pectoris BA40 Approved [35]
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [53]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [54]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [55]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [56]
Proguanil DMBL79I Malaria 1F40-1F45 Approved [57]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [57]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [58]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [59]
Capsaicin DMGMF6V Back pain ME84.Z Approved [60]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [61]
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Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [36]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [37]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [38]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [39]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [40]
Sulfasalazine DMICA9H Irritable bowel syndrome DD91.0 Approved [41]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [42]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [43]
Verapamil DMA7PEW Angina pectoris BA40 Approved [44]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [39]
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [53]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [54]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [59]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [59]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [62]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [63]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [64]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [65]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [66]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [67]
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Drug(s) Metabolized By NADPH-cytochrome P450 reductase (CPR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [45]
Daunorubicin DMQUSBT Acute monocytic leukemia Approved [46]
Nitrofurantoin DM7PQIK Urinary tract infection GC08 Approved [47]
Benzphetamine DMIJATC Obesity 5B81 Approved [48]
Nilutamide DMFN07X Prostate cancer 2C82.0 Approved [49]
Menadiol sodium diphosphate DMP9N85 Coagulation defect 3B10.0 Approved [50]
Amrubicin DM6SGUB Small-cell lung cancer 2C25.Y Phase 3 [51]
Nitrobenzodiazepine DM254EW N. A. N. A. Investigative [52]
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Drug(s) Metabolized By Ribosomal 23S RNA methyltransferase Erm (erm)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Pentamycin DM92LH2 Vulvovaginitis GA02.0 Approved [8]
Pentamycin DM92LH2 Vulvovaginitis GA02.0 Approved [8]
Drug(s) Affected By NADPH--cytochrome P450 reductase (POR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [68]
Selenium DM25CGV N. A. N. A. Approved [69]
Quercetin DM3NC4M Obesity 5B81 Approved [70]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [71]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [72]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [73]
Leflunomide DMR8ONJ Arthritis FA20 Approved [74]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [65]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [66]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [75]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Flupentixol DM0DJ9O Schizophrenia 6A20 Approved [76]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [77]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [78]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [79]
Cepharanthine DM9Y5JB N. A. N. A. Approved [80]
Itraconazole DMCR1MV Aspergillosis 1F20 Approved [81]
Clozapine DMFC71L Schizophrenia 6A20 Approved [82]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [83]
Trifluoperazine DMKBYWI Anxiety Approved [84]
Olanzapine DMPFN6Y Bipolar depression Approved [82]
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Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [85]
Gabapentin DM6T924 Complex partial seizure 8A68.0 Approved [16]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [86]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [87]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [88]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [89]
Prednisone DM2HG4X Acute asthma CA23 Approved [90]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [91]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [92]
Methotrexate DM2TEOL Anterior urethra cancer Approved [93]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cytochrome b-245 light chain (CYBA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [94]
Quercetin DM3NC4M Obesity 5B81 Approved [95]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [96]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [72]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [97]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [98]
Testosterone DM7HUNW Hot flushes GA30 Approved [99]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Testosterone enanthate DMB6871 N. A. N. A. Approved [101]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [66]
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Drug(s) Affected By Nitric oxide synthase 3 (NOS3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [102]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [85]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [16]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [103]
Methotrexate DM2TEOL Anterior urethra cancer Approved [104]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [105]
Quercetin DM3NC4M Obesity 5B81 Approved [106]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [107]
Fructose DM43AN2 Vomiting MD90 Approved [108]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [109]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Bile salt export pump (ABCB11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [110]
Ezetimibe DM7A8TW Atherosclerosis BD40 Approved [111]
Glipizide DMZA5PQ Diabetic complication 5A2Y Approved [111]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [112]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [110]
Ofloxacin DM0VQN3 Acute gonococcal cervicitis Approved [111]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [113]
Gefitinib DM15F0X Colon adenocarcinoma Approved [110]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [13]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [110]
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Drug(s) Affected By Natural cytotoxicity triggering receptor 3 (NCR3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [114]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [115]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [116]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [117]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [118]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [119]
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Drug(s) Affected By Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [69]
Quercetin DM3NC4M Obesity 5B81 Approved [95]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [65]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [66]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [75]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [120]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [68]
Methotrexate DM2TEOL Anterior urethra cancer Approved [121]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [118]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [122]
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Drug(s) Affected By Rho guanine nucleotide exchange factor 11 (ARHGEF11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [116]
Urethane DM7NSI0 N. A. N. A. Phase 4 [123]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [122]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [122]
Fasudil DMTCNOM Discovery agent N.A. Investigative [124]
Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [125]
Gefitinib DM15F0X Colon adenocarcinoma Approved [126]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [127]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [128]
Etretinate DM2CZFA Keratosis ED56 Approved [129]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [130]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [131]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [132]
Quercetin DM3NC4M Obesity 5B81 Approved [133]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [134]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Actin-related protein 2/3 complex subunit 5 (ARPC5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [136]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [100]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [137]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [75]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [120]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [138]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [139]
chloropicrin DMSGBQA Discovery agent N.A. Investigative [140]
⏷ Show the Full List of 9 Drug(s)
Drug(s) Affected By G2/mitotic-specific cyclin-B2 (CCNB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [141]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [125]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [142]
Methotrexate DM2TEOL Anterior urethra cancer Approved [143]
Quercetin DM3NC4M Obesity 5B81 Approved [95]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [12]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [145]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [146]
Testosterone DM7HUNW Hot flushes GA30 Approved [147]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Zinc finger protein SNAI1 (SNAI1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [148]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [149]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [150]
Quercetin DM3NC4M Obesity 5B81 Approved [151]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [152]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [153]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [154]
Leflunomide DMR8ONJ Arthritis FA20 Approved [74]
Aldosterone DM9S2JW Hypertension BA00-BA04 Approved [155]
Sanguinarine DMDINFS Dental plaque DA08.4 Approved [156]
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Drug(s) Affected By Insulin (INS)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [157]
Methotrexate DM2TEOL Anterior urethra cancer Approved [93]
Epinephrine DM3KJBC Acute asthma CA23 Approved [158]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [159]
Fructose DM43AN2 Vomiting MD90 Approved [160]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [161]
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [162]
Clonidine DM6RZ9Q Attention deficit hyperactivity disorder 6A05.Z Approved [163]
Propranolol DM79NTF Angina pectoris BA40 Approved [164]
Testosterone DM7HUNW Hot flushes GA30 Approved [165]
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Drug(s) Affected By Tumor necrosis factor (TNF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [166]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [167]
Fructose DM43AN2 Vomiting MD90 Approved [16]
Ketoprofen DMRKXPT Bursitis Approved [16]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [168]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [169]
Baclofen DM0QV1J Multiple sclerosis 8A40 Approved [170]
Gefitinib DM15F0X Colon adenocarcinoma Approved [171]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [172]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [173]
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Drug(s) Affected By Interferon gamma (IFNG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [174]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [175]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [176]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [177]
Methotrexate DM2TEOL Anterior urethra cancer Approved [93]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [178]
Quercetin DM3NC4M Obesity 5B81 Approved [179]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [180]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [181]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [182]
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Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [183]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [184]
Gefitinib DM15F0X Colon adenocarcinoma Approved [185]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [186]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [187]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [186]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [188]
Selenium DM25CGV N. A. N. A. Approved [189]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [190]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [191]
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Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [16]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [192]
Diazepam DM08E9O Alcohol withdrawal Approved [193]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [194]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [195]
Methotrexate DM2TEOL Anterior urethra cancer Approved [196]
Ceruletide DM2WE5K Caerulein stimulated gastric and pancreatic secretion 5A4Y Approved [197]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [198]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [199]
Quercetin DM3NC4M Obesity 5B81 Approved [200]
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Drug(s) Affected By Fibronectin (FN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [201]
Methotrexate DM2TEOL Anterior urethra cancer Approved [93]
Quercetin DM3NC4M Obesity 5B81 Approved [202]
Aripiprazole DM3NUMH Bipolar I disorder Approved [203]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [204]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [205]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [206]
Ethacrynic acid DM60QMR Edema MG29 Approved [207]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [208]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [209]
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Drug(s) Affected By Granulocyte-macrophage colony-stimulating factor (CSF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [210]
Quercetin DM3NC4M Obesity 5B81 Approved [211]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [71]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [212]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [213]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [214]
Testosterone DM7HUNW Hot flushes GA30 Approved [99]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [215]
Acetylcholine DMDF79Z Cataract 9B10 Approved [216]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [217]
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Drug(s) Affected By Interleukin-4 (IL4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [218]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [89]
Tolnaftate DM28MU7 Dermatophytosis 1F28.2 Approved [219]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [220]
Salicyclic acid DM2F8XZ Acne vulgaris ED80 Approved [221]
Prednisone DM2HG4X Acute asthma CA23 Approved [222]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [177]
Methotrexate DM2TEOL Anterior urethra cancer Approved [93]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [178]
Cladribine DM3JDRP Hairy cell leukaemia 2A82.2 Approved [223]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-5 (IL5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [175]
Tolnaftate DM28MU7 Dermatophytosis 1F28.2 Approved [219]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [220]
Prednisone DM2HG4X Acute asthma CA23 Approved [90]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [224]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [225]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [226]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [227]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [228]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [229]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-3 (IL3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [93]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [230]
Ethanol DMDRQZU Chronic pain MG30 Approved [230]
Menthol DMG2KW7 Back pain ME84.Z Approved [231]
Betamethasone Valerate DMMIAXO Dermatological disease DA24.Y Approved [232]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [218]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [116]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [16]
Famotidine DMRL3AB Gastric ulcer DA60 Approved [16]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [16]
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Drug(s) Affected By Heme oxygenase 1 (HMOX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [233]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [234]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [235]
Verapamil DMA7PEW Angina pectoris BA40 Approved [236]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [184]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [237]
Selenium DM25CGV N. A. N. A. Approved [238]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [239]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [240]
Methotrexate DM2TEOL Anterior urethra cancer Approved [241]
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Drug(s) Affected By Cadherin-1 (CDH1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [194]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [149]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [242]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [243]
Liraglutide DM3FXPS Non-insulin dependent diabetes 5A11 Approved [244]
Quercetin DM3NC4M Obesity 5B81 Approved [95]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [245]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [246]
Polyethylene glycol DM4I1JP Constipation DD91.1 Approved [247]
Panobinostat DM58WKG Chronic graft versus host disease Approved [248]
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Drug(s) Affected By C-C motif chemokine 5 (CCL5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [249]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [250]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [175]
Methotrexate DM2TEOL Anterior urethra cancer Approved [93]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [251]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [144]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [72]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [252]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [253]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [254]
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Drug(s) Affected By Ras-related protein Rab-4A (RAB4A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [72]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [65]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [66]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [75]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [120]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [255]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [72]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [118]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [256]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [122]
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Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fructose DM43AN2 Vomiting MD90 Approved [16]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [257]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [183]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [184]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [237]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [258]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [259]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [260]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [261]
Quercetin DM3NC4M Obesity 5B81 Approved [95]
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Drug(s) Affected By T-lymphocyte activation antigen CD80 (CD80)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [262]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [263]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [264]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [265]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [266]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [267]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [268]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [267]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [269]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [270]
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Drug(s) Affected By T-lymphocyte activation antigen CD86 (CD86)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [271]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [175]
Kanamycin DM2DMPO Bacteremia 1A73 Approved [272]
Methotrexate DM2TEOL Anterior urethra cancer Approved [93]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [273]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [272]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [274]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [272]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [275]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [276]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [277]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [278]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [279]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [280]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [281]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [282]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [283]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [284]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [257]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Troponin T, cardiac muscle (TNNT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [285]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [246]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [66]
Folic Acid DMEMBJC Colorectal carcinoma Approved [286]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [120]
Arsenic DMTL2Y1 N. A. N. A. Approved [287]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [68]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [288]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [289]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [290]
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Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [119]
Gefitinib DM15F0X Colon adenocarcinoma Approved [291]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [292]
Epinephrine DM3KJBC Acute asthma CA23 Approved [293]
Quercetin DM3NC4M Obesity 5B81 Approved [294]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [71]
Fructose DM43AN2 Vomiting MD90 Approved [295]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [296]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [297]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [298]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glycogen synthase kinase-3 alpha (GSK3A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [69]
Quercetin DM3NC4M Obesity 5B81 Approved [299]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [15]
Methamphetamine DMPM4SK Anxiety Approved [300]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [301]
Urethane DM7NSI0 N. A. N. A. Phase 4 [123]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [302]
Epigallocatechin gallate DMCGWBJ Hepatic fibrosis DB93.0 Phase 3 [299]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [69]
Adaphostin DM16QSG Chronic myelogenous leukaemia 2A20.0 Phase 1 [303]
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Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [304]
Gefitinib DM15F0X Colon adenocarcinoma Approved [305]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [306]
Selenium DM25CGV N. A. N. A. Approved [69]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [307]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [308]
Quercetin DM3NC4M Obesity 5B81 Approved [309]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [310]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [311]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Eotaxin (CCL11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Prednisone DM2HG4X Acute asthma CA23 Approved [312]
Methotrexate DM2TEOL Anterior urethra cancer Approved [93]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [224]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [253]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [313]
Ethanol DMDRQZU Chronic pain MG30 Approved [230]
Chloroquine DMSI5CB Malaria 1F40-1F45 Approved [314]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [116]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [68]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [315]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C chemokine receptor type 3 (CCR3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [316]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [317]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [318]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [319]
Indomethacin DMSC4A7 Bursitis Approved [320]
Arsenic DMTL2Y1 N. A. N. A. Approved [321]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [118]
⏷ Show the Full List of 7 Drug(s)
Drug(s) Affected By LIM domain kinase 1 (LIMK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [322]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [65]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [66]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [120]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [323]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [174]
Ximelegatran DMU8ANS Myocardial infarction BA41-BA43 Approved [324]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [325]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [326]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Interleukin-2 (IL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sirolimus DMGW1ID Advanced cancer 2A00-2F9Z Approved [16]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [89]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [220]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [327]
Methotrexate DM2TEOL Anterior urethra cancer Approved [328]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [329]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [225]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [227]
Fentanyl DM8WAHT Analgesia MB40.8 Approved [330]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [331]
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Drug(s) Affected By Neutrophil gelatinase-associated lipocalin (LCN2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [332]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [333]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [333]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [334]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [335]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [336]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [65]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [66]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [337]
Gentamicin DMKINJO Bacteremia 1A73 Approved [338]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Apoptosis regulator BAX (BAX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [339]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [257]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [332]
Verapamil DMA7PEW Angina pectoris BA40 Approved [340]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [194]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [341]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [342]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [343]
Meloxicam DM2AR7L Arthritis FA20 Approved [344]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [345]
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Drug(s) Affected By Lethal(2) giant larvae protein homolog 1 (LLGL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [135]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [346]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [75]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [256]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [347]
Milchsaure DM462BT Pruritus EC90 Investigative [348]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [248]
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Drug(s) Affected By Calcineurin subunit B type 1 (PPP3R1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [66]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [75]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [349]
Bortezomib DMNO38U Leukemia Approved [350]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [120]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [351]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [68]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [16]
Sirolimus DMGW1ID Advanced cancer 2A00-2F9Z Approved [16]
Cimetidine DMH61ZB Acid-reflux disorder DA22 Approved [16]
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Drug(s) Affected By Catalase (CAT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [187]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [352]
Haloperidol DM96SE0 Delirium Approved [16]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [353]
Selenium DM25CGV N. A. N. A. Approved [354]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [355]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [356]
Methotrexate DM2TEOL Anterior urethra cancer Approved [93]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [357]
Quercetin DM3NC4M Obesity 5B81 Approved [95]
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Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [237]
Selenium DM25CGV N. A. N. A. Approved [189]
Methotrexate DM2TEOL Anterior urethra cancer Approved [358]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [359]
Epinephrine DM3KJBC Acute asthma CA23 Approved [360]
Quercetin DM3NC4M Obesity 5B81 Approved [361]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [362]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [363]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [364]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [365]
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Drug(s) Affected By Peroxisome proliferator-activated receptor alpha (PPARA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [93]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [96]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [366]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [367]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [368]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [369]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [370]
Testosterone DM7HUNW Hot flushes GA30 Approved [147]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [371]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [65]
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Drug(s) Affected By Cytochrome P450 3A7 (CYP3A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [333]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [65]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [63]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [372]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [373]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [374]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [375]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [376]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [377]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [363]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Calcineurin (PPP3CA) TTA4LDE PP2BA_HUMAN Inhibitor [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) Main DME DE4LYSA CP3A4_HUMAN Substrate [5]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Substrate [6]
NADPH-cytochrome P450 reductase (CPR) DE3N2FM NCPR_HUMAN Substrate [7]
Ribosomal 23S RNA methyltransferase Erm (erm) DEW6V07 A0A5N1AHF6_CORAY Substrate [8]
Ribosomal 23S RNA methyltransferase Erm (erm) DEA65D8 A0A381KDL2_CORJE Substrate [8]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
Actin-related protein 2/3 complex subunit 5 (ARPC5) OTFNMMDL ARPC5_HUMAN Gene/Protein Processing [9]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Gene/Protein Processing [10]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Drug Response [11]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Gene/Protein Processing [12]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Gene/Protein Processing [13]
C-C chemokine receptor type 3 (CCR3) OT6GBUFA CCR3_HUMAN Gene/Protein Processing [14]
C-C motif chemokine 5 (CCL5) OTSCA5CK CCL5_HUMAN Gene/Protein Processing [14]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Gene/Protein Processing [15]
Calcineurin subunit B type 1 (PPP3R1) OTGQNFJQ CANB1_HUMAN Drug Response [16]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Protein Interaction/Cellular Processes [10]

References

1 Tacrolimus FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6784).
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