Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZRQU7)

• Drug Name: [3H]cAMP Drug Info
• Synonyms: Cyclic AMP; cAMP; 60-92-4; Adenosine 3',5'-cyclic monophosphate; 3',5'-cyclic AMP; Adenosine 3',5'-phosphate; Adenosine 3',5'-cyclophosphate; cyclic 3',5'-AMP; Adenosine cyclic monophosphate; cyclic 3',5'-Adenylic acid; Adenosine 3',5'-monophosphate; Adenosine-3',5'-cyclophosphate; Adenosine cyclophosphate; Cyclic Adenosine Monophosphate; cyclic Adenosine 3',5'-phosphate; Cyclic adenylic acid; Adenosine cyclic 3',5'-monophosphate; 3',5'-AMP; cyclic Adenosine 3',5'-monophosphate; Adenosine cyclic 3',5'-phosphate; [3H]-cAMP

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 6076
  ChEBI ID: CHEBI:17489
  CAS Number: CAS 60-92-4
  TTD Drug ID: DMZRQU7
  VARIDT Drug ID: DR00295
  INTEDE Drug ID: DR2052

Molecule-Related Drug Atlas

Drug(s) Targeting cAMP-dependent protein kinase A type I (PRKAR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
RO-316233	DMAGLPW	Discovery agent	N.A.	Investigative	[17]
AdoC(Dpr)2AlaArg6	DM2TWSZ	Discovery agent	N.A.	Investigative	[18]
AdcAhxArg4NH(CH2)6NH2	DMSYMRJ	Discovery agent	N.A.	Investigative	[19]
AdcAhxArg4Lys-PEGOMe	DMQ2C8X	Discovery agent	N.A.	Investigative	[19]
AdoC(GABA)Arg6	DMMWNPT	Discovery agent	N.A.	Investigative	[18]
AdcAhxArg4Lys(biotin)-PEG-OMe	DMZYJHV	Discovery agent	N.A.	Investigative	[19]
AdoC(Aun)Arg6	DMDLHAB	Discovery agent	N.A.	Investigative	[18]
Cyclic Guanosine Monophosphate	DMOU93V	Discovery agent	N.A.	Investigative	[2]
AdoCGlyArg6	DMVQJP0	Discovery agent	N.A.	Investigative	[18]
AdoC(Aoc)Arg6	DMRSCO2	Discovery agent	N.A.	Investigative	[18]

Drug(s) Targeting Adenylate cyclase (ADCY)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ad5-AC6	DMQNFZE	Cardiac failure	BD10-BD13	Terminated	[20]
N6-CYCLOPENTYLADENOSINE	DMD6AJO	Discovery agent	N.A.	Investigative	[21]
[3H]alphabeta-meATP	DMWV5C3	Discovery agent	N.A.	Investigative	[2]
NSC-88915	DM9WIHJ	Solid tumour/cancer	2A00-2F9Z	Investigative	[22]
2-hydroxy-17beta-estradiol	DMM9Z0B	Discovery agent	N.A.	Investigative	[22]
2,5-didesoxy-3-ATP	DM5CWM0	Discovery agent	N.A.	Investigative	[22]
		N. A.	N. A.		[23]
		N. A.	N. A.		[23]
		N. A.	N. A.		[23]
		N. A.	N. A.		[23]

Drug(s) Targeting cAMP protein kinase type II-beta (PRKAR2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BALANOL	DMDLN9E	N. A.	N. A.	Terminated	[24]
4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol	DMSKJ1X	Discovery agent	N.A.	Investigative	[25]
Ro-4396686	DM5DMCH	Discovery agent	N.A.	Investigative	[26]
AdoC(Dpr)2AlaArg6	DM2TWSZ	Discovery agent	N.A.	Investigative	[18]
AdcAhxArg4NH(CH2)6NH2	DMSYMRJ	Discovery agent	N.A.	Investigative	[19]
AdcAhxArg4Lys-PEGOMe	DMQ2C8X	Discovery agent	N.A.	Investigative	[19]
AdoC(GABA)Arg6	DMMWNPT	Discovery agent	N.A.	Investigative	[18]
AdcAhxArg4Lys(biotin)-PEG-OMe	DMZYJHV	Discovery agent	N.A.	Investigative	[19]
AdoC(Aun)Arg6	DMDLHAB	Discovery agent	N.A.	Investigative	[18]
AdoCGlyArg6	DMVQJP0	Discovery agent	N.A.	Investigative	[18]

Drug(s) Targeting Fungal Protein kinase A (Fung ypkA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BALANOL	DMDLN9E	N. A.	N. A.	Terminated	[24]
4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol	DMSKJ1X	Discovery agent	N.A.	Investigative	[25]
Ro-4396686	DM5DMCH	Discovery agent	N.A.	Investigative	[26]
PMID20005102C1	DMMESBW	Discovery agent	N.A.	Investigative	[27]
PMID19364658C33	DMSE1C3	Discovery agent	N.A.	Investigative	[28]
BX-912	DMZA45C	Discovery agent	N.A.	Investigative	[29]
BX-795	DMRIMLJ	Discovery agent	N.A.	Investigative	[29]
chelerythrine	DMCP1G9	Discovery agent	N.A.	Investigative	[30]
PMID21742770C1	DME3JMH	Discovery agent	N.A.	Investigative	[31]
Rp-adenosine 3',5'-cyclic monophosphothioate triethylamine (Rp-cAMPS)	DM1JWGH	Discovery agent	N.A.	Investigative	[32]

Drug(s) Transported By Multidrug resistance-associated protein 4 (ABCC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[33]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[34]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[35]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[36]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[37]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[38]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[39]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[41]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[37]

Drug(s) Transported By Multidrug resistance-associated protein 5 (ABCC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[42]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[42]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[35]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[43]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[44]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[45]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[46]
FLUORESCEIN	DMQTFAO	Ocular disease	1F00.1Z	Approved	[47]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[48]
Adenosine	DMM2NSK	Paroxysmal supraventricular tachycardia	BC81.Z	Approved	[49]

Drug(s) Metabolized By Phosphodiesterase 7B (PDE7B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[50]

Drug(s) Affected By 3',5'-cyclic-AMP phosphodiesterase 7B (PDE7B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[51]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[53]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[55]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[56]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[60]

Drug(s) Affected By ATP-binding cassette sub-family C member 4 (ABCC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[61]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[62]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[63]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[64]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[66]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[67]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]

Drug(s) Affected By 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (HSD3B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[71]
Topiramate	DM82Z30	Alcohol dependence	6C40.2	Approved	[72]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[72]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Metyrapone	DMI7FVQ	Cushing disease	5A70	Approved	[75]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[71]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[76]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[77]
Levetiracetam	DMTGDN8	Epilepsy	8A60-8A68	Approved	[74]

Drug(s) Affected By Cytochrome P450 11B1, mitochondrial (CYP11B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[78]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[79]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[82]
Potassium Chloride	DMMTAJC	Hypokalemia	5C77	Approved	[83]
Mitotane	DMU1GX0	Adrenocortical carcinoma	2D11.Z	Approved	[84]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[85]
Dalcetrapib	DMKNCVM	Acute coronary syndrome	BA41	Phase 3	[86]
Anacetrapib	DMP2BFG	Arteriosclerosis	BD40	Phase 3	[86]

Drug(s) Affected By Cholesterol side-chain cleavage enzyme, mitochondrial (CYP11A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[87]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[88]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[90]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[82]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[91]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[92]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[93]

Drug(s) Affected By Aromatase (CYP19A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[94]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[95]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[96]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[97]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[96]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[98]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[79]
Bifonazole	DM3KN7V	Fungal infection	1F29-1F2F	Approved	[99]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[100]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[96]

Drug(s) Affected By Prolactin (PRL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[101]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[102]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[103]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[104]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[98]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[105]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[106]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[107]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[108]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[109]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[110]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[111]
Fructose	DM43AN2	Vomiting	MD90	Approved	[85]
Ketoprofen	DMRKXPT	Bursitis		Approved	[85]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[112]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[113]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[114]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[115]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[116]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[117]

Drug(s) Affected By Estrogen receptor (ESR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[118]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[119]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[120]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[121]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[122]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[125]
Procaine	DM4LSNE	Anaesthesia	9A78.6	Approved	[121]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[126]

Drug(s) Affected By Trefoil factor 1 (TFF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[127]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[129]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[130]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[131]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[132]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[129]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[133]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[134]
Exemestane	DM9HPW3	Hormonally-responsive breast cancer	2C60-2C65	Approved	[135]

Drug(s) Affected By Inhibin beta A chain (INHBA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[137]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[139]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[140]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[141]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[142]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[143]

Drug(s) Affected By Granulocyte colony-stimulating factor (CSF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[144]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[145]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[146]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[147]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[148]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[149]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[150]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[151]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[152]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[153]

Drug(s) Affected By Cystic fibrosis transmembrane conductance regulator (CFTR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivacaftor	DMZC1HS	Cystic fibrosis	CA25	Approved	[154]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[155]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[156]
Miglustat	DM5J64S	Niemann-Pick disease type C		Approved	[157]
Glibenclamide	DM8JXPZ	Diabetic complication	5A2Y	Approved	[158]
Milrinone	DM8TUPF	Congestive heart failure	BD10	Approved	[155]
Oxidized glutathione	DM9EQC0	Breast cancer	2C60-2C65	Approved	[159]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[159]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]

Drug(s) Affected By Serine/threonine-protein kinase B-raf (BRAF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[161]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[162]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[163]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[165]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[167]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[168]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[169]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[170]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[171]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[173]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[137]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[174]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[175]
Mirtazapine	DML53ZJ	Depression	6A70-6A7Z	Approved	[176]
Methamphetamine	DMPM4SK	Anxiety		Approved	[177]

Drug(s) Affected By Ras-related protein Rap-1A (RAP1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[178]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[179]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[180]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[181]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[66]
Minodronate	DM50PMY	Osteoporosis	FB83.0	Approved	[182]
Risedronate	DM5FLTY	Bone Paget disease		Approved	[183]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[184]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[165]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[183]

Drug(s) Affected By Hormone-sensitive lipase (LIPE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[185]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[186]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[185]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[187]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[188]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[141]
Vitamin B3	DMQVRZH	Chronic renal failure	GB61.Z	Approved	[189]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[190]
CS-038	DM67P0F	Type-2 diabetes	5A11	Phase 3	[188]

Drug(s) Affected By Histone-arginine methyltransferase CARM1 (CARM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[97]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[191]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[181]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[192]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[193]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[194]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[195]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[190]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[196]

Drug(s) Affected By Aquaporin-3 (AQP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[197]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[198]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[199]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[200]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[173]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[137]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[199]

Drug(s) Affected By NADH dehydrogenase 1 beta subcomplex subunit 11, mitochondrial (NDUFB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[193]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[201]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[202]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[203]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[190]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[204]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[205]

Drug(s) Affected By Glycoprotein hormones alpha chain (CGA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[206]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Octreotide	DMHIDCJ	Acromegaly	5A60.0	Approved	[207]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[142]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[208]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[209]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[210]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[211]

Drug(s) Affected By Thyrotropin receptor (TSHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[212]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[213]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[214]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[214]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[215]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[213]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[216]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[217]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[218]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[219]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[145]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[220]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[221]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[222]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[221]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[223]
Selenium	DM25CGV	N. A.	N. A.	Approved	[224]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[225]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[226]

Drug(s) Affected By High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (PDE8B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[141]
Roflumilast	DMPGHY8	Asthma	CA23	Approved	[227]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[204]
Trequinsin	DMQRSMD	N. A.	N. A.	Terminated	[227]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[228]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[229]

Drug(s) Affected By 5-hydroxytryptamine receptor 7 (HTR7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[200]
Cyproheptadine	DM92AH3	Allergic rhinitis	CA08.0	Approved	[230]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[230]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[231]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[232]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[233]
PD-0325901	DM27D4J	Breast cancer	2C60-2C65	Phase 2	[234]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[204]
SL65.0472	DMU5RKC	Cardiovascular disease	BA00-BE2Z	Discontinued in Phase 2	[235]
SB-269970	DM8WTGA	Sleep-wake disorder	7A00-7B2Z	Terminated	[230]

Drug(s) Affected By High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (PDE8A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[197]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[236]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[237]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[238]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[165]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[238]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[238]

Drug(s) Affected By High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[237]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[238]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[239]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[240]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[241]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[242]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[243]

Drug(s) Affected By Lutropin subunit beta (LHB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[244]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[245]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[246]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[247]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[248]
Alprazolam	DMC7XDN	Anxiety		Approved	[249]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Norethindrone acetate	DMDGCQP	N. A.	N. A.	Approved	[245]
Metoclopramide	DMFA5MY	Nausea	MD90	Approved	[247]
Cetrorelix	DMFD9Q6	Ovarian stimulation	LB45.1	Approved	[250]

Drug(s) Affected By Leptin (LEP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[251]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[117]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[252]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[253]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[254]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[251]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[251]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[255]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[256]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[257]

Drug(s) Affected By cAMP-dependent protein kinase catalytic subunit beta (PRKACB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[258]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[259]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[193]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[258]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[260]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[261]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[168]

Drug(s) Affected By cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[262]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[190]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[262]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[262]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[262]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[228]

Drug(s) Affected By Organic anion transporter 3 (SLC22A8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[263]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[264]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[265]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[266]
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[267]
Cimetidine	DMH61ZB	Acid-reflux disorder	DA22	Approved	[267]
Cefdinir	DMJ7A0H	Bacterial infection	1A00-1C4Z	Approved	[268]
Cefaclor	DMJXDGC	Bacterial infection	1A00-1C4Z	Approved	[268]
Famotidine	DMRL3AB	Gastric ulcer	DA60	Approved	[269]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[270]

Drug(s) Affected By Prokineticin-1 (PROK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[241]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[240]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[271]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[272]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[204]

Drug(s) Affected By Histamine H2 receptor (HRH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[181]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[273]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[190]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[271]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[204]

Drug(s) Affected By Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (PDE11A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[228]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[137]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[59]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[274]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[204]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[275]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[228]

Drug(s) Affected By Thyrotropin subunit beta (TSHB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[276]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Octreotide	DMHIDCJ	Acromegaly	5A60.0	Approved	[277]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[278]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[279]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[280]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[281]
NITRATE	DMVFB93	Discovery agent	N.A.	Investigative	[282]

Drug(s) Affected By Parathyroid hormone-related protein (PTHLH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[283]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[199]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[284]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[285]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[286]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[138]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[287]

Drug(s) Affected By Vasopressin V2 receptor (AVPR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[288]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[204]

Drug(s) Affected By Hydroxycarboxylic acid receptor 3 (HCAR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[181]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[138]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[231]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[289]
Vitamin B3	DMQVRZH	Chronic renal failure	GB61.Z	Approved	[290]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[239]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[291]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[243]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[292]

Drug(s) Affected By Adiponectin (ADIPOQ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[251]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[251]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[293]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[147]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[251]
Cilazapril	DM4V6JA	Congestive heart failure	BD10	Approved	[294]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[295]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[251]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[255]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[296]

Drug(s) Affected By Interleukin-4 (IL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[297]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[298]
Tolnaftate	DM28MU7	Dermatophytosis	1F28.2	Approved	[299]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[300]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[301]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[302]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[303]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[98]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[304]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[305]

Drug(s) Affected By Beta-3 adrenergic receptor (ADRB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[306]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[307]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[239]
Phenylephrine	DMZHUO5	Allergic rhinitis	CA08.0	Approved	[308]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[204]
[3H]CGP12177	DMZN1A3	Discovery agent	N.A.	Investigative	[309]
Cyanopindolol	DMIBLGH	Discovery agent	N.A.	Investigative	[310]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[311]

Drug(s) Affected By Beta-1 adrenergic receptor (ADRB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dobutamine	DMD1B8Z	Heart failure	BD10-BD13	Approved	[312]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[313]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Vortioxetine	DM6F1PU	Major depressive disorder	6A70.3	Approved	[314]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[174]
Labetalol	DMK8U72	Hypertension	BA00-BA04	Approved	[315]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[316]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[317]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[190]

Drug(s) Affected By Dickkopf-related protein 1 (DKK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[318]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[319]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[200]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[320]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[321]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[285]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[193]

Drug(s) Affected By Beta-2 adrenergic receptor (ADRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salmeterol	DMIEU69	Allergic asthma	CA23.0	Approved	[322]
Bambuterol	DMKLSHF	Asthma	CA23	Approved	[323]
Terbutaline	DMD4381	Asthma	CA23	Approved	[324]
Salbutamol	DMN9CWF	Acute asthma	CA23	Approved	[325]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[326]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[52]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[327]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[200]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[328]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[329]

Drug(s) Affected By High affinity 3',5'-cyclic-AMP phosphodiesterase 7A (PDE7A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[200]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[69]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Bortezomib	DMNO38U	Leukemia		Approved	[260]
Roflumilast	DMPGHY8	Asthma	CA23	Approved	[227]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[58]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[190]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[204]
Trequinsin	DMQRSMD	N. A.	N. A.	Terminated	[227]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[228]

Drug(s) Affected By Choriogonadotropin subunit beta 3 (CGB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[172]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[256]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[330]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[81]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[331]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[175]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[331]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Bezafibrate	DMZDCS0	Hypercholesterolaemia	5C80.0	Approved	[332]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[333]

Drug(s) Affected By Calcitonin (CALCA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ranitidine	DM0GUSX	Gastric ulcer	DA60	Approved	[334]
Fructose	DM43AN2	Vomiting	MD90	Approved	[335]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[65]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[262]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[336]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[337]
Nizatidine	DMGFV3Z	Acid-reflux disorder	DA22	Approved	[334]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[338]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[231]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[339]

Drug(s) Affected By Hydroxycarboxylic acid receptor 2 (HCAR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[181]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[164]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[160]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[337]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[291]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[243]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[204]
cinnamic acid	DM340FH	Discovery agent	N.A.	Investigative	[340]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[341]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adenylate cyclase (ADCY)	TT2QM9D	NOUNIPROTAC	Inhibitor	[2]
cAMP protein kinase type II-beta (PRKAR2B)	TTW4Y2M	KAP3_HUMAN	Inhibitor	[2]
cAMP-dependent protein kinase A type I (PRKAR1A)	TTNAHEX	KAP0_HUMAN	Inhibitor	[2]
Fungal Protein kinase A (Fung ypkA)	TTYVI76	Q56921_YEREN	Activator	[3]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Multidrug resistance-associated protein 5 (ABCC5)	DTYVM24	MRP5_HUMAN	Substrate	[4]
Multidrug resistance-associated protein 4 (ABCC4)	DTCSGPB	MRP4_HUMAN	Substrate	[5]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Phosphodiesterase 7B (PDE7B) Main DME	DEON3ED	PDE7B_HUMAN	Substrate	[6]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (HSD3B2)	OT02MSKN	3BHS2_HUMAN	Gene/Protein Processing	[7]
3',5'-cyclic-AMP phosphodiesterase 7B (PDE7B)	OTK3SHT2	PDE7B_HUMAN	Biotransformations	[8]
5-hydroxytryptamine receptor 7 (HTR7)	OT44DEWB	5HT7R_HUMAN	Regulation of Drug Effects	[9]
Adiponectin (ADIPOQ)	OTNX23LE	ADIPO_HUMAN	Regulation of Drug Effects	[10]
Aquaporin-3 (AQP3)	OT2J7JPD	AQP3_HUMAN	Gene/Protein Processing	[11]
Aromatase (CYP19A1)	OTZ6XF74	CP19A_HUMAN	Gene/Protein Processing	[12]
ATP-binding cassette sub-family C member 4 (ABCC4)	OTO27PAL	MRP4_HUMAN	Regulation of Drug Effects	[13]
Beta-1 adrenergic receptor (ADRB1)	OTQBWN4U	ADRB1_HUMAN	Regulation of Drug Effects	[14]
Beta-2 adrenergic receptor (ADRB2)	OTSDOX4Q	ADRB2_HUMAN	Biotransformations	[15]
Beta-3 adrenergic receptor (ADRB3)	OTPMG4V7	ADRB3_HUMAN	Regulation of Drug Effects	[16]

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