General Information of Drug (ID: DMZRQU7)

Drug Name
[3H]cAMP Drug Info
Synonyms
Cyclic AMP; cAMP; 60-92-4; Adenosine 3',5'-cyclic monophosphate; 3',5'-cyclic AMP; Adenosine 3',5'-phosphate; Adenosine 3',5'-cyclophosphate; cyclic 3',5'-AMP; Adenosine cyclic monophosphate; cyclic 3',5'-Adenylic acid; Adenosine 3',5'-monophosphate; Adenosine-3',5'-cyclophosphate; Adenosine cyclophosphate; Cyclic Adenosine Monophosphate; cyclic Adenosine 3',5'-phosphate; Cyclic adenylic acid; Adenosine cyclic 3',5'-monophosphate; 3',5'-AMP; cyclic Adenosine 3',5'-monophosphate; Adenosine cyclic 3',5'-phosphate; [3H]-cAMP
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
6076
ChEBI ID
CHEMBL316966
CAS Number
CAS 60-92-4
TTD Drug ID
DMZRQU7
VARIDT Drug ID
DR00295
INTEDE Drug ID
DR2052

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DTP
DME
DOT
Drug Status:
Investigative Drug(s)
Discontinued Drug(s)
Approved Drug(s)
Clinical Trial Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
RO-316233 DMAGLPW Discovery agent N.A. Investigative [17]
AdoC(Dpr)2AlaArg6 DM2TWSZ Discovery agent N.A. Investigative [18]
AdcAhxArg4NH(CH2)6NH2 DMSYMRJ Discovery agent N.A. Investigative [19]
AdcAhxArg4Lys-PEGOMe DMQ2C8X Discovery agent N.A. Investigative [19]
AdoC(GABA)Arg6 DMMWNPT Discovery agent N.A. Investigative [18]
AdcAhxArg4Lys(biotin)-PEG-OMe DMZYJHV Discovery agent N.A. Investigative [19]
AdoC(Aun)Arg6 DMDLHAB Discovery agent N.A. Investigative [18]
Cyclic Guanosine Monophosphate DMOU93V Discovery agent N.A. Investigative [2]
AdoCGlyArg6 DMVQJP0 Discovery agent N.A. Investigative [18]
AdoC(Aoc)Arg6 DMRSCO2 Discovery agent N.A. Investigative [18]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Targeting Adenylate cyclase (ADCY)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ad5-AC6 DMQNFZE Cardiac failure BD10-BD13 Terminated [20]
N6-CYCLOPENTYLADENOSINE DMD6AJO Discovery agent N.A. Investigative [21]
[3H]alphabeta-meATP DMWV5C3 Discovery agent N.A. Investigative [2]
NSC-88915 DM9WIHJ Solid tumour/cancer 2A00-2F9Z Investigative [22]
2-hydroxy-17beta-estradiol DMM9Z0B Discovery agent N.A. Investigative [22]
2,5-didesoxy-3-ATP DM5CWM0 Discovery agent N.A. Investigative [22]
N. A. N. A. [23]
N. A. N. A. [23]
N. A. N. A. [23]
N. A. N. A. [23]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BALANOL DMDLN9E N. A. N. A. Terminated [24]
4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol DMSKJ1X Discovery agent N.A. Investigative [25]
Ro-4396686 DM5DMCH Discovery agent N.A. Investigative [26]
AdoC(Dpr)2AlaArg6 DM2TWSZ Discovery agent N.A. Investigative [18]
AdcAhxArg4NH(CH2)6NH2 DMSYMRJ Discovery agent N.A. Investigative [19]
AdcAhxArg4Lys-PEGOMe DMQ2C8X Discovery agent N.A. Investigative [19]
AdoC(GABA)Arg6 DMMWNPT Discovery agent N.A. Investigative [18]
AdcAhxArg4Lys(biotin)-PEG-OMe DMZYJHV Discovery agent N.A. Investigative [19]
AdoC(Aun)Arg6 DMDLHAB Discovery agent N.A. Investigative [18]
AdoCGlyArg6 DMVQJP0 Discovery agent N.A. Investigative [18]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BALANOL DMDLN9E N. A. N. A. Terminated [24]
4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol DMSKJ1X Discovery agent N.A. Investigative [25]
Ro-4396686 DM5DMCH Discovery agent N.A. Investigative [26]
PMID20005102C1 DMMESBW Discovery agent N.A. Investigative [27]
PMID19364658C33 DMSE1C3 Discovery agent N.A. Investigative [28]
BX-912 DMZA45C Discovery agent N.A. Investigative [29]
BX-795 DMRIMLJ Discovery agent N.A. Investigative [29]
chelerythrine DMCP1G9 Discovery agent N.A. Investigative [30]
PMID21742770C1 DME3JMH Discovery agent N.A. Investigative [31]
Rp-adenosine 3',5'-cyclic monophosphothioate triethylamine (Rp-cAMPS) DM1JWGH Discovery agent N.A. Investigative [32]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [33]
Folic Acid DMEMBJC Colorectal carcinoma Approved [34]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [35]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [36]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [37]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [38]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [39]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [40]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [41]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [37]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [42]
Folic Acid DMEMBJC Colorectal carcinoma Approved [42]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [35]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [43]
Mercaptopurine DMTM2IK Acute lymphoblastic leukaemia 2A85 Approved [44]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [45]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [46]
FLUORESCEIN DMQTFAO Ocular disease 1F00.1Z Approved [47]
Pemetrexed DMMX2E6 Central nervous system lymphoma 2B33.5 Approved [48]
Adenosine DMM2NSK Paroxysmal supraventricular tachycardia BC81.Z Approved [49]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Metabolized By Phosphodiesterase 7B (PDE7B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Testosterone enanthate DMB6871 N. A. N. A. Approved [50]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [51]
Quercetin DM3NC4M Obesity 5B81 Approved [52]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [53]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [54]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [55]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [56]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [57]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [58]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [59]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [60]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [61]
Topiramate DM82Z30 Alcohol dependence 6C40.2 Approved [62]
Lamotrigine DM8SXYG Bipolar disorder 6A60 Approved [62]
Lindane DMB8CNL Infestations of lice and scabies 1G00.Z Approved [63]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [64]
Metyrapone DMI7FVQ Cushing disease 5A70 Approved [65]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [61]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [66]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [67]
Levetiracetam DMTGDN8 Epilepsy 8A60-8A68 Approved [64]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fructose DM43AN2 Vomiting MD90 Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [70]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [71]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [72]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [73]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [74]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [75]
Mirtazapine DML53ZJ Depression 6A70-6A7Z Approved [76]
Methamphetamine DMPM4SK Anxiety Approved [77]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ibandronate DM0QZBN Hypercalcaemia 5B91.0 Approved [78]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [79]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [80]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [81]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [56]
Minodronate DM50PMY Osteoporosis FB83.0 Approved [82]
Risedronate DM5FLTY Bone Paget disease Approved [83]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [84]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [85]
Pamidronate DMB4AVP Bone Paget disease Approved [83]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [73]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [86]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [87]
Arsenic DMTL2Y1 N. A. N. A. Approved [88]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [89]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [90]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [91]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [92]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [93]
⏷ Show the Full List of 9 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [59]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [73]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [94]
Roflumilast DMPGHY8 Asthma CA23 Approved [95]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [96]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [92]
Trequinsin DMQRSMD N. A. N. A. Terminated [95]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [97]
Sulforaphane DMQY3L0 Skin disease EA00-EM0Z Investigative [98]
⏷ Show the Full List of 9 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [99]
Cyproheptadine DM92AH3 Allergic rhinitis CA08.0 Approved [100]
Clozapine DMFC71L Schizophrenia 6A20 Approved [100]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [101]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [102]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [103]
PD-0325901 DM27D4J Breast cancer 2C60-2C65 Phase 2 [104]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [92]
SL65.0472 DMU5RKC Cardiovascular disease BA00-BE2Z Discontinued in Phase 2 [105]
SB-269970 DM8WTGA Sleep-wake disorder 7A00-7B2Z Terminated [100]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [106]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [55]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [107]
Testosterone DM7HUNW Hot flushes GA30 Approved [108]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [109]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [109]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [85]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [73]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [109]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [109]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [55]
Testosterone DM7HUNW Hot flushes GA30 Approved [108]
Leflunomide DMR8ONJ Arthritis FA20 Approved [110]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [109]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [73]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [111]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [112]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [113]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [114]
Urethane DM7NSI0 N. A. N. A. Phase 4 [115]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Lutropin subunit beta (LHB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [116]
Levonorgestrel DM1DP7T Atypical endometrial hyperplasia Approved [117]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [118]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [119]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [120]
Alprazolam DMC7XDN Anxiety Approved [121]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [73]
Norethindrone acetate DMDGCQP N. A. N. A. Approved [117]
Metoclopramide DMFA5MY Nausea MD90 Approved [119]
Cetrorelix DMFD9Q6 Ovarian stimulation LB45.1 Approved [122]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [123]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [59]
Testosterone enanthate DMB6871 N. A. N. A. Approved [124]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [125]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [86]
Motexafin gadolinium DMEJKRF Brain cancer 2A00 Approved [123]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [126]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [127]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [128]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [55]
Panobinostat DM58WKG Chronic graft versus host disease Approved [129]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [130]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [131]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [96]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [91]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [129]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [129]
PDX-101 DM6OC53 Plasma cell myeloma 2A83.1 Phase 2 [129]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [97]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valsartan DMREUQ6 Chronic heart failure BD1Z Approved [132]
Methotrexate DM2TEOL Anterior urethra cancer Approved [133]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [134]
Dinoprostone DMTYOPD Medical abortion JA00.1Z Approved [135]
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [136]
Cimetidine DMH61ZB Acid-reflux disorder DA22 Approved [136]
Cefdinir DMJ7A0H Bacterial infection 1A00-1C4Z Approved [137]
Cefaclor DMJXDGC Bacterial infection 1A00-1C4Z Approved [137]
Famotidine DMRL3AB Gastric ulcer DA60 Approved [138]
Tetracycline DMZA017 Acne vulgaris ED80 Approved [139]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Prokineticin-1 (PROK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [113]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [112]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [140]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [141]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [92]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [97]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [55]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [71]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [73]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [131]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [96]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [142]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [92]
Glyphosate DM0AFY7 Malaria 1F40-1F45 Investigative [143]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [97]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [144]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [73]
Octreotide DMHIDCJ Acromegaly 5A60.0 Approved [145]
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [146]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [147]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [148]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [149]
NITRATE DMVFB93 Discovery agent N.A. Investigative [150]
⏷ Show the Full List of 8 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [151]
Ceruletide DM2WE5K Caerulein stimulated gastric and pancreatic secretion 5A4Y Approved [152]
Quercetin DM3NC4M Obesity 5B81 Approved [153]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [154]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [155]
Testosterone DM7HUNW Hot flushes GA30 Approved [156]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [72]
Leflunomide DMR8ONJ Arthritis FA20 Approved [110]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [157]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [158]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [159]
Isoproterenol DMK7MEY Atrioventricular block Approved [160]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [111]
Phenylephrine DMZHUO5 Allergic rhinitis CA08.0 Approved [161]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [92]
[3H]CGP12177 DMZN1A3 Discovery agent N.A. Investigative [162]
Cyanopindolol DMIBLGH Discovery agent N.A. Investigative [163]
KOJIC ACID DMP84CS Discovery agent N.A. Investigative [164]
⏷ Show the Full List of 8 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Dobutamine DMD1B8Z Heart failure BD10-BD13 Approved [165]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [166]
Methotrexate DM2TEOL Anterior urethra cancer Approved [151]
Vortioxetine DM6F1PU Major depressive disorder 6A70.3 Approved [167]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [73]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [74]
Labetalol DMK8U72 Hypertension BA00-BA04 Approved [168]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [169]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [170]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [91]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Salmeterol DMIEU69 Allergic asthma CA23.0 Approved [171]
Bambuterol DMKLSHF Asthma CA23 Approved [172]
Terbutaline DMD4381 Asthma CA23 Approved [173]
Salbutamol DMN9CWF Acute asthma CA23 Approved [174]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [175]
Methotrexate DM2TEOL Anterior urethra cancer Approved [151]
Epinephrine DM3KJBC Acute asthma CA23 Approved [176]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [99]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [177]
Ergotidine DM78IME Osteoarthritis FA00-FA05 Approved [178]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [69]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [179]
Testosterone enanthate DMB6871 N. A. N. A. Approved [180]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [73]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [181]
Pioglitazone DMKJ485 Amyotrophic lateral sclerosis 8B60.0 Approved [75]
Alitretinoin DMME8LH Kaposi sarcoma 2B57 Approved [181]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [131]
Bezafibrate DMZDCS0 Hypercholesterolaemia 5C80.0 Approved [182]
Testosterone DM7HUNW Hot flushes GA30 Approved [183]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Calcitonin (CALCA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ranitidine DM0GUSX Gastric ulcer DA60 Approved [184]
Fructose DM43AN2 Vomiting MD90 Approved [185]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [55]
Panobinostat DM58WKG Chronic graft versus host disease Approved [129]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [186]
Folic Acid DMEMBJC Colorectal carcinoma Approved [187]
Nizatidine DMGFV3Z Acid-reflux disorder DA22 Approved [184]
Capsaicin DMGMF6V Back pain ME84.Z Approved [188]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [101]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [189]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [81]
Leflunomide DMR8ONJ Arthritis FA20 Approved [110]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [157]
Folic Acid DMEMBJC Colorectal carcinoma Approved [187]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [131]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [190]
Urethane DM7NSI0 N. A. N. A. Phase 4 [115]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [92]
cinnamic acid DM340FH Discovery agent N.A. Investigative [191]
Milchsaure DM462BT Pruritus EC90 Investigative [192]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Adenylate cyclase (ADCY) TT2QM9D NOUNIPROTAC Inhibitor [2]
cAMP protein kinase type II-beta (PRKAR2B) TTW4Y2M KAP3_HUMAN Inhibitor [2]
cAMP-dependent protein kinase A type I (PRKAR1A) TTNAHEX KAP0_HUMAN Inhibitor [2]
Fungal Protein kinase A (Fung ypkA) TTYVI76 Q56921_YEREN Activator [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Multidrug resistance-associated protein 5 (ABCC5) DTYVM24 MRP5_HUMAN Substrate [4]
Multidrug resistance-associated protein 4 (ABCC4) DTCSGPB MRP4_HUMAN Substrate [5]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Phosphodiesterase 7B (PDE7B) Main DME DEON3ED PDE7B_HUMAN Substrate [6]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (HSD3B2) OT02MSKN 3BHS2_HUMAN Gene/Protein Processing [7]
5-hydroxytryptamine receptor 7 (HTR7) OT44DEWB 5HT7R_HUMAN Regulation of Drug Effects [8]
ATP-binding cassette sub-family C member 4 (ABCC4) OTO27PAL MRP4_HUMAN Regulation of Drug Effects [9]
Beta-1 adrenergic receptor (ADRB1) OTQBWN4U ADRB1_HUMAN Regulation of Drug Effects [10]
Beta-2 adrenergic receptor (ADRB2) OTSDOX4Q ADRB2_HUMAN Biotransformations [11]
Beta-3 adrenergic receptor (ADRB3) OTPMG4V7 ADRB3_HUMAN Regulation of Drug Effects [12]
Calcitonin (CALCA) OTZ11LHB CALC_HUMAN Regulation of Drug Effects [13]
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (PDE10A) OT74EK7Z PDE10_HUMAN Biotransformations [14]
cAMP-dependent protein kinase catalytic subunit beta (PRKACB) OT6RMDCE KAPCB_HUMAN Drug Response [15]
Choriogonadotropin subunit beta 3 (CGB3) OTVM2SU3 CGB3_HUMAN Regulation of Drug Effects [16]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5096).
2 How many drug targets are there Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1694).
4 The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides. J Biol Chem. 2000 Sep 29;275(39):30069-74.
5 cAMP regulates expression of the cyclic nucleotide transporter MRP4 (ABCC4) through the EPAC pathway. Pharmacogenet Genomics. 2014 Oct;24(10):522-6.
6 Cloning and characterization of the human and mouse PDE7B, a novel cAMP-specific cyclic nucleotide phosphodiesterase. Biochem Biophys Res Commun. 2000 May 27;272(1):186-92.
7 Inhibitory effects of cholesterol sulfate on progesterone production in human granulosa-like tumor cell line, KGN. Endocr J. 2008 Jul;55(3):575-81.
8 Presence of a 5-HT7 receptor positively coupled to adenylate cyclase activation in human granulosa-lutein cells. J Clin Endocrinol Metab. 2000 Mar;85(3):1277-86. doi: 10.1210/jcem.85.3.6448.
9 The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP. J Am Soc Nephrol. 2002 Mar;13(3):595-603.
10 Constitutive activity of the human beta(1)-adrenergic receptor in beta(1)-receptor transgenic mice. Mol Pharmacol. 2001 Oct;60(4):712-7.
11 A polymorphism-specific "memory" mechanism in the (2)-adrenergic receptor. Sci Signal. 2011 Aug 9;4(185):ra53. doi: 10.1126/scisignal.2001681.
12 Comparative pharmacology of human beta-adrenergic receptor subtypes--characterization of stably transfected receptors in CHO cells. Naunyn Schmiedebergs Arch Pharmacol. 2004 Feb;369(2):151-9. doi: 10.1007/s00210-003-0860-y. Epub 2004 Jan 17.
13 Volatile anesthetics inhibit calcitonin gene-related peptide receptor-mediated responses in pithed rats and human neuroblastoma cells. J Pharmacol Exp Ther. 2004 Dec;311(3):1016-22. doi: 10.1124/jpet.104.071936. Epub 2004 Aug 5.
14 Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A). J Biol Chem. 1999 Jun 25;274(26):18438-45. doi: 10.1074/jbc.274.26.18438.
15 Activating PRKACB somatic mutation in cortisol-producing adenomas. JCI Insight. 2018 Apr 19;3(8):e98296. doi: 10.1172/jci.insight.98296. eCollection 2018 Apr 19.
16 Upregulation of peripubertal rat Leydig cell steroidogenesis following 24 h in vitro and in vivo exposure to atrazine. Toxicol Sci. 2010 Nov;118(1):52-60. doi: 10.1093/toxsci/kfq227. Epub 2010 Jul 28.
17 Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides. J Med Chem. 1992 Jan;35(1):177-84.
18 Adenosine-5'-carboxylic acid peptidyl derivatives as inhibitors of protein kinases. Bioorg Med Chem Lett. 1999 May 17;9(10):1447-52.
19 Liquid-phase synthesis of a pegylated adenosine-oligoarginine conjugate, cell-permeable inhibitor of cAMP-dependent protein kinase. Bioorg Med Chem Lett. 2003 Sep 15;13(18):3035-9.
20 Unanticipated Signaling Events Associated with Cardiac Adenylyl Cyclase Gene Transfer. J Mol Cell Cardiol. 2011 May; 50(5): 751-758.
21 Activity of N6-substituted 2-chloroadenosines at A1 and A2 adenosine receptors. J Med Chem. 1991 Dec;34(12):3388-90.
22 Structure-based development of novel adenylyl cyclase inhibitors. J Med Chem. 2008 Aug 14;51(15):4456-64.
23 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.
24 Joys of molecules. 2. Endeavors in chemical biology and medicinal chemistry. J Med Chem. 2005 Sep 8;48(18):5613-38. Address;
25 4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects. J Med Chem. 2006 Nov 2;49(22):6500-9.
26 Biological evaluation of a multi-targeted small molecule inhibitor of tumor-induced angiogenesis. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1950-3.
27 2,3,5-Trisubstituted pyridines as selective AKT inhibitors. Part II: Improved drug-like properties and kinase selectivity from azaindazoles. Bioorg Med Chem Lett. 2010 Jan 15;20(2):679-83.
28 Identification and SAR of squarate inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2). Bioorg Med Chem. 2009 May 1;17(9):3342-51.
29 Novel small molecule inhibitors of 3-phosphoinositide-dependent kinase-1. J Biol Chem. 2005 May 20;280(20):19867-74.
30 A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8.
31 A Potent and Selective Quinoxalinone-Based STK33 Inhibitor Does Not Show Synthetic Lethality in KRAS-Dependent Cells. ACS Med Chem Lett. 2012 Dec 13;3(12):1034-1038.
32 Inhibition of protein kinase A activity interferes with long-term, but not short-term, memory of conditioned taste aversions. Behav Neurosci. 2002 Dec;116(6):1070-4.
33 Interaction of nonsteroidal anti-inflammatory drugs with multidrug resistance protein (MRP) 2/ABCC2- and MRP4/ABCC4-mediated methotrexate transport. J Pharmacol Exp Ther. 2007 Jan;320(1):229-35.
34 Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system. Cancer Res. 2002 Jun 1;62(11):3144-50.
35 ATP-binding cassette C transporters in human pancreatic carcinoma cell lines. Upregulation in 5-fluorouracil-resistant cells. Pancreatology. 2009;9(1-2):136-44.
36 The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9244-9.
37 Human intestinal transporter database: QSAR modeling and virtual profiling of drug uptake, efflux and interactions. Pharm Res. 2013 Apr;30(4):996-1007.
38 Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4). Biochem J. 2003 Apr 15;371(Pt 2):361-7.
39 P-glycoprotein, but not multidrug resistance protein 4, plays a role in the systemic clearance of irinotecan and SN-38 in mice. Drug Metab Lett. 2010 Dec;4(4):195-201.
40 Polymorphisms in multidrug resistance-associated protein gene 4 is associated with outcome in childhood acute lymphoblastic leukemia. Blood. 2009 Aug 13;114(7):1383-6.
41 Role of glutathione in the multidrug resistance protein 4 (MRP4/ABCC4)-mediated efflux of cAMP and resistance to purine analogues. Biochem J. 2002 Feb 1;361(Pt 3):497-503.
42 The human multidrug resistance protein MRP5 transports folates and can mediate cellular resistance against antifolates. Cancer Res. 2005 May 15;65(10):4425-30.
43 Celecoxib upregulates multidrug resistance proteins in colon cancer: lack of synergy with standard chemotherapy. Curr Cancer Drug Targets. 2008 Aug;8(5):414-20.
44 Overexpression of MRP4 (ABCC4) and MRP5 (ABCC5) confer resistance to the nucleoside analogs cytarabine and troxacitabine, but not gemcitabine. Springerplus. 2014 Dec 13;3:732.
45 Cellular export of drugs and signaling molecules by the ATP-binding cassette transporters MRP4 (ABCC4) and MRP5 (ABCC5). Drug Metab Rev. 2005;37(1):253-78.
46 Interdependence of gemcitabine treatment, transporter expression, and resistance in human pancreatic carcinoma cells. Neoplasia. 2010 Sep;12(9):740-7.
47 Hyaluronan export by the ABC transporter MRP5 and its modulation by intracellular cGMP. J Biol Chem. 2007 Jul 20;282(29):20999-1004.
48 Kinetic validation of the use of carboxydichlorofluorescein as a drug surrogate for MRP5-mediated transport. Eur J Pharm Sci. 2006 Apr;27(5):524-32.
49 Role of MRP4 and MRP5 in biology and chemotherapy. AAPS PharmSci. 2002;4(3):E14.
50 PDE7B is involved in nandrolone decanoate hydrolysis in liver cytosol and its transcription is up-regulated by androgens in HepG2. Front Pharmacol. 2014 May 30;5:132.
51 Methotrexate normalizes up-regulated folate pathway genes in rheumatoid arthritis. Arthritis Rheum. 2013 Nov;65(11):2791-802.
52 Activation of beta-catenin signalling by GSK-3 inhibition increases p-glycoprotein expression in brain endothelial cells. J Neurochem. 2008 Aug;106(4):1855-65. doi: 10.1111/j.1471-4159.2008.05537.x. Epub 2008 Jul 4.
53 ATP binding cassette multidrug transporters limit the anti-HIV activity of zidovudine and indinavir in infected human macrophages. Antivir Ther. 2004 Aug;9(4):519-28.
54 Selenium-dependent and -independent transport of arsenic by the human multidrug resistance protein 2 (MRP2/ABCC2): implications for the mutual detoxification of arsenic and selenium. Carcinogenesis. 2010 Aug;31(8):1450-5. doi: 10.1093/carcin/bgq125. Epub 2010 Jun 27.
55 Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
56 Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury. Arch Toxicol. 2020 Apr;94(4):1151-1172. doi: 10.1007/s00204-020-02691-9. Epub 2020 Mar 10.
57 Hematopoietic stem cell differentiation affects expression and function of MRP4 (ABCC4), a transport protein for signaling molecules and drugs. Int J Cancer. 2009 May 15;124(10):2303-11. doi: 10.1002/ijc.24207.
58 Prolonged use of aspirin alters human and rat intestinal cells and thereby limits the absorption of clopidogrel. Clin Pharmacol Ther. 2011 Oct;90(4):612-9. doi: 10.1038/clpt.2011.163. Epub 2011 Sep 7.
59 Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
60 Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
61 Cinnamic acid based thiazolidinediones inhibit human P450c17 and 3beta-hydroxysteroid dehydrogenase and improve insulin sensitivity independent of PPARgamma agonist activity. J Mol Endocrinol. 2004 Apr;32(2):425-36.
62 Effects of anticonvulsants on human p450c17 (17alpha-hydroxylase/17,20 lyase) and 3beta-hydroxysteroid dehydrogenase type 2. Epilepsia. 2005 Mar;46(3):444-8.
63 Steroidogenic gene expression in H295R cells and the human adrenal gland: adrenotoxic effects of lindane in vitro. J Appl Toxicol. 2006 Nov-Dec;26(6):484-92.
64 Differential effects of antiepileptic drugs on steroidogenesis in a human in vitro cell model. Acta Neurol Scand Suppl. 2009;(189):14-21.
65 The H295R system for evaluation of endocrine-disrupting effects. Ecotoxicol Environ Saf. 2006 Nov;65(3):293-305.
66 Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029.
67 Pioglitazone inhibits androgen production in NCI-H295R cells by regulating gene expression of CYP17 and HSD3B2. Mol Pharmacol. 2007 Mar;71(3):787-98.
68 Fructose modulates GLUT5 mRNA stability in differentiated Caco-2 cells: role of cAMP-signalling pathway and PABP (polyadenylated-binding protein)-interacting protein (Paip) 2. Biochem J. 2003 Oct 1;375(Pt 1):167-74. doi: 10.1042/BJ20030661.
69 Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
70 In vitro study of transporters involved in intestinal absorption of inorganic arsenic. Chem Res Toxicol. 2012 Feb 20;25(2):446-53. doi: 10.1021/tx200491f. Epub 2012 Jan 26.
71 Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
72 Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
73 Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
74 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
75 Peroxisome proliferator activated receptor gamma (PPAR-gama) ligand pioglitazone regulated gene networks in term human primary trophoblast cells. Reprod Toxicol. 2018 Oct;81:99-107.
76 Effects of different antipsychotics and the antidepressant mirtazapine on glucose transporter mRNA levels in human blood cells. J Psychiatr Res. 2006 Jun;40(4):374-9. doi: 10.1016/j.jpsychires.2005.04.016. Epub 2005 Jul 5.
77 Microglial and astrocytic changes in the striatum of methamphetamine abusers. Leg Med (Tokyo). 2010 Mar;12(2):57-62. doi: 10.1016/j.legalmed.2009.11.001. Epub 2010 Jan 27.
78 Extracellular calcium increases bisphosphonate-induced growth inhibition of breast cancer cells. Breast Cancer Res. 2008;10(1):R4. doi: 10.1186/bcr1845. Epub 2008 Jan 11.
79 Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells. J Cell Biochem. 2006 Aug 1;98(5):1163-84.
80 Statin-induced Mitochondrial Priming Sensitizes Multiple Myeloma Cells to BCL2 and MCL-1 Inhibitors. Cancer Res Commun. 2023 Dec 8;3(12):2497-2509. doi: 10.1158/2767-9764.CRC-23-0350.
81 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
82 Efficacy of a nitrogen-containing bisphosphonate, minodronate, in conjunction with a p38 mitogen activated protein kinase inhibitor or doxorubicin against malignant bone tumor cells. Cancer Chemother Pharmacol. 2008 Jun;62(1):111-6. doi: 10.1007/s00280-007-0580-y. Epub 2007 Sep 15.
83 Nitrogen-containing bisphosphonates induce apoptosis of Caco-2 cells in vitro by inhibiting the mevalonate pathway: a model of bisphosphonate-induced gastrointestinal toxicity. Bone. 2001 Oct;29(4):336-43. doi: 10.1016/s8756-3282(01)00589-0.
84 Synergistic interaction of lovastatin and paclitaxel in human cancer cells. Mol Cancer Ther. 2001 Dec;1(2):141-9.
85 Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
86 Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
87 Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
88 Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
89 Human 3D multicellular microtissues: an upgraded model for the in vitro mechanistic investigation of inflammation-associated drug toxicity. Toxicol Lett. 2019 Sep 15;312:34-44.
90 Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. Genome Res. 2012 Nov;22(11):2153-62.
91 Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
92 Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
93 Alternatives for the worse: Molecular insights into adverse effects of bisphenol a and substitutes during human adipocyte differentiation. Environ Int. 2021 Nov;156:106730. doi: 10.1016/j.envint.2021.106730. Epub 2021 Jun 27.
94 Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
95 Dynamic activation of cystic fibrosis transmembrane conductance regulator by type 3 and type 4D phosphodiesterase inhibitors. J Pharmacol Exp Ther. 2005 Aug;314(2):846-54. doi: 10.1124/jpet.105.083519. Epub 2005 May 18.
96 Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
97 DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
98 Transcriptome and DNA methylation changes modulated by sulforaphane induce cell cycle arrest, apoptosis, DNA damage, and suppression of proliferation in human liver cancer cells. Food Chem Toxicol. 2020 Feb;136:111047. doi: 10.1016/j.fct.2019.111047. Epub 2019 Dec 12.
99 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
100 Clozapine and other competitive antagonists reactivate risperidone-inactivated h5-HT7 receptors: radioligand binding and functional evidence for GPCR homodimer protomer interactions. Psychopharmacology (Berl). 2010 Dec;212(4):687-97. doi: 10.1007/s00213-010-2001-x. Epub 2010 Sep 9.
101 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
102 Multi-level gene expression profiles affected by thymidylate synthase and 5-fluorouracil in colon cancer. BMC Genomics. 2006 Apr 3;7:68. doi: 10.1186/1471-2164-7-68.
103 Physiogenomic association of statin-related myalgia to serotonin receptors. Muscle Nerve. 2007 Sep;36(3):329-35. doi: 10.1002/mus.20871.
104 PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies. Nature. 2014 Oct 9;514(7521):247-51.
105 Profiling 976 ToxCast chemicals across 331 enzymatic and receptor signaling assays. Chem Res Toxicol. 2013 Jun 17;26(6):878-95.
106 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
107 Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Toxicol Appl Pharmacol. 2012 Jun 1;261(2):204-16.
108 The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
109 Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
110 Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
111 Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
112 Endometrial receptivity is affected in women with high circulating progesterone levels at the end of the follicular phase: a functional genomics analysis. Hum Reprod. 2011 Jul;26(7):1813-25.
113 Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
114 LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
115 Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
116 Erectile function and nocturnal penile tumescence in patients with prostate cancer undergoing luteinizing hormone-releasing hormone agonist therapy. Int J Urol. 1999 Jan;6(1):19-23. doi: 10.1046/j.1442-2042.1999.06128.x.
117 Relative progestational and androgenic activity of four progestins used for male hormonal contraception assessed in vitro in relation to their ability to suppress LH secretion in the castrate male rat. Mol Cell Endocrinol. 2010 Oct 26;328(1-2):16-21. doi: 10.1016/j.mce.2010.06.010. Epub 2010 Jun 25.
118 Chronic senescent human mesenchymal stem cells as possible contributor to the wound healing disorder after exposure to the alkylating agent sulfur mustard. Arch Toxicol. 2021 Feb;95(2):727-747. doi: 10.1007/s00204-020-02946-5. Epub 2021 Jan 25.
119 Differences in the opioid control of luteinizing hormone secretion between pathological and iatrogenic hyperprolactinemic states. J Clin Endocrinol Metab. 1987 Mar;64(3):508-12. doi: 10.1210/jcem-64-3-508.
120 Rapid-onset hypogonadism secondary to crizotinib use in men with metastatic nonsmall cell lung cancer. Cancer. 2012 Nov 1;118(21):5302-9. doi: 10.1002/cncr.27450. Epub 2012 Apr 4.
121 The effect of alprazolam on serum cortisol and luteinizing hormone pulsatility in normal women and in women with stress-related anovulation. J Clin Endocrinol Metab. 1995 Mar;80(3):818-23. doi: 10.1210/jcem.80.3.7883836.
122 Pharmacokinetics of new testosterone transdermal therapeutic systems in gonadotropin-releasing hormone antagonist-suppressed normal men. Exp Clin Endocrinol Diabetes. 1999;107(1):63-9. doi: 10.1055/s-0029-1212075.
123 Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
124 Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
125 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
126 The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
127 The genomic response of a human uterine endometrial adenocarcinoma cell line to 17alpha-ethynyl estradiol. Toxicol Sci. 2009 Jan;107(1):40-55.
128 Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNF-mediated hepatotoxicity. Toxicol Sci. 2014 Jul;140(1):144-59. doi: 10.1093/toxsci/kfu072. Epub 2014 Apr 20.
129 A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
130 Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells. Chem Res Toxicol. 2014 Mar 17;27(3):408-20.
131 Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
132 Uric acid accumulation in the kidney triggers mast cell degranulation and aggravates renal oxidative stress. Toxicology. 2023 Jan 1;483:153387. doi: 10.1016/j.tox.2022.153387. Epub 2022 Dec 1.
133 P-gp, MRP2 and OAT1/OAT3 mediate the drug-drug interaction between resveratrol and methotrexate. Toxicol Appl Pharmacol. 2016 Sep 1;306:27-35. doi: 10.1016/j.taap.2016.06.030. Epub 2016 Jul 1.
134 Intracellular concentrations determine the cytotoxicity of adefovir, cidofovir and tenofovir. Toxicol In Vitro. 2015 Feb;29(1):251-8. doi: 10.1016/j.tiv.2014.10.019.
135 Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol. 2001 May;59(5):1277-86.
136 A species difference in the transport activities of H2 receptor antagonists by rat and human renal organic anion and cation transporters. J Pharmacol Exp Ther. 2005 Oct;315(1):337-45.
137 Human organic anion transporter hOAT3 is a potent transporter of cephalosporin antibiotics, in comparison with hOAT1. Biochem Pharmacol. 2005 Oct 1;70(7):1104-13.
138 Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A). Eur J Pharmacol. 2004 Oct 25;503(1-3):25-30.
139 Human organic anion transporters mediate the transport of tetracycline. Jpn J Pharmacol. 2002 Jan;88(1):69-76.
140 Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
141 Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
142 CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.
143 Evaluation of estrogen receptor alpha activation by glyphosate-based herbicide constituents. Food Chem Toxicol. 2017 Oct;108(Pt A):30-42.
144 Effect of 1 alpha-hydroxyvitamin D3 on serum levels of thyroid hormones in hyperthyroid patients with untreated Graves' disease. Metabolism. 1997 Oct;46(10):1184-8. doi: 10.1016/s0026-0495(97)90214-6.
145 Long-term efficacy and tolerability of octreotide treatment in acromegaly. Metabolism. 1992 Sep;41(9 Suppl 2):44-50. doi: 10.1016/0026-0495(92)90030-e.
146 Effects of terguride on anterior pituitary function in parkinsonian patients treated with L-dopa: a double-blind study versus placebo. Clin Neuropharmacol. 1996 Feb;19(1):72-80. doi: 10.1097/00002826-199619010-00006.
147 Post-myocardial infarction mortality in patients with ventricular premature depolarizations. Canadian Amiodarone Myocardial Infarction Arrhythmia Trial Pilot Study. Circulation. 1991 Aug;84(2):550-7. doi: 10.1161/01.cir.84.2.550.
148 Dynamic monitoring of cardio-specific markers and markers of thyroid gland function in cancer patients--a pilot study. Anticancer Res. 2007 Jul-Aug;27(4A):1883-6.
149 Amiodarone stimulates interleukin-6 production in cultured human thyrocytes, exerting cytotoxic effects on thyroid follicles in suspension culture. Thyroid. 2001 Feb;11(2):101-9. doi: 10.1089/105072501300042703.
150 Goitrogenic anions, thyroid-stimulating hormone, and thyroid hormone in infants. Environ Health Perspect. 2010 Sep;118(9):1332-7. doi: 10.1289/ehp.0901736. Epub 2010 Apr 27.
151 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
152 Acinar cell-specific knockout of the PTHrP gene decreases the proinflammatory and profibrotic responses in pancreatitis. Am J Physiol Gastrointest Liver Physiol. 2014 Sep 1;307(5):G533-49. doi: 10.1152/ajpgi.00428.2013. Epub 2014 Jul 17.
153 Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
154 All-trans retinoic acid induced hypercalcemia in a patient with acute promyelocytic leukemia: its relation to increased PTH-rP. Int J Hematol. 1994 Feb;59(2):143-4.
155 THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
156 Parathyroid hormone-related protein varies with sex and androgen status in nonsmall cell lung cancer. Cancer. 2007 Sep 15;110(6):1313-20. doi: 10.1002/cncr.22922.
157 Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
158 From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
159 Impact of rosiglitazone on the expression of beta3-AR in the stable cell lines expressed beta3-AR gene. Clin Chem Lab Med. 2007;45(11):1511-6. doi: 10.1515/CCLM.2007.315.
160 Discovery of a novel series of biphenyl benzoic acid derivatives as highly potent and selective human beta3 adrenergic receptor agonists with good oral bioavailability. Part II. J Med Chem. 2008 Jul 10;51(13):4002-20. doi: 10.1021/jm8000345. Epub 2008 Jun 14.
161 Characterization of beta3-adrenoceptors in human internal mammary artery and putative involvement in coronary artery bypass management. J Am Coll Cardiol. 2005 Jul 19;46(2):351-9. doi: 10.1016/j.jacc.2005.03.061.
162 Synthesis and characterization of high-affinity 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled fluorescent ligands for human -adrenoceptors. J Med Chem. 2011 Oct 13;54(19):6874-87. doi: 10.1021/jm2008562. Epub 2011 Sep 16.
163 Selective activation of beta3-adrenoceptors by octopamine: comparative studies in mammalian fat cells. Naunyn Schmiedebergs Arch Pharmacol. 1999 Apr;359(4):310-21. doi: 10.1007/pl00005357.
164 Toxicogenomics of kojic acid on gene expression profiling of a375 human malignant melanoma cells. Biol Pharm Bull. 2006 Apr;29(4):655-69.
165 The Arg389Gly 1-adrenoceptor gene polymorphism influences the acute effects of -adrenoceptor blockade on contractility in the human heart. Clin Res Cardiol. 2011 Aug;100(8):641-7. doi: 10.1007/s00392-011-0288-1. Epub 2011 Feb 11.
166 Agonist actions of "beta-blockers" provide evidence for two agonist activation sites or conformations of the human beta1-adrenoceptor. Mol Pharmacol. 2003 Jun;63(6):1312-21. doi: 10.1124/mol.63.6.1312.
167 Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder. J Med Chem. 2011 May 12;54(9):3206-21. doi: 10.1021/jm101459g. Epub 2011 Apr 12.
168 Preclinical pharmacologic properties of dilevalol, an antihypertensive agent possessing selective beta 2 agonist-mediated vasodilation and beta antagonism. Am J Cardiol. 1989 Jun 5;63(19):3I-6I. doi: 10.1016/0002-9149(89)90120-3.
169 Effects of chronic amiodarone treatment on human myocardial beta adrenoceptor density and adenylate cyclase response. Cardiovasc Res. 1991 Jun;25(6):503-9. doi: 10.1093/cvr/25.6.503.
170 Analysis of estrogen agonism and antagonism of tamoxifen, raloxifene, and ICI182780 in endometrial cancer cells: a putative role for the epidermal growth factor receptor ligand amphiregulin. J Soc Gynecol Investig. 2005 Oct;12(7):e55-67.
171 Pleiotropic beta-agonist-promoted receptor conformations and signals independent of intrinsic activity. Am J Respir Cell Mol Biol. 2007 Feb;36(2):236-43. doi: 10.1165/rcmb.2006-0257OC. Epub 2006 Sep 15.
172 Development of 3D-QSAR models for predicting the activities of chemicals to stimulate muscle growth via (2)-adrenoceptor. Toxicol In Vitro. 2021 Dec;77:105251. doi: 10.1016/j.tiv.2021.105251. Epub 2021 Sep 30.
173 Beta2-adrenergic receptor polymorphisms in African American children with status asthmaticus. Pediatr Crit Care Med. 2006 Jan;7(1):15-8. doi: 10.1097/01.pcc.0000194010.63115.a2.
174 beta2-adrenergic receptor polymorphisms and salbutamol-stimulated energy expenditure. J Clin Endocrinol Metab. 2005 Apr;90(4):2301-7. doi: 10.1210/jc.2004-1356. Epub 2005 Feb 1.
175 Neutrophil beta(2)-adrenoceptor function in major depression: G(s) coupling, effects of imipramine and relationship to treatment outcome. Eur J Pharmacol. 1999 Dec 15;386(2-3):135-44. doi: 10.1016/s0014-2999(99)00749-9.
176 Myocardial ischaemia and ventricular arrhthymias precipitated by physiological concentrations of adrenaline in patients with coronary artery disease. Br Heart J. 1992 May;67(5):419-20. doi: 10.1136/hrt.67.5.419-b.
177 Hormonal regulation of beta2-adrenergic receptor level in prostate cancer. Prostate. 2008 Jul 1;68(10):1133-42. doi: 10.1002/pros.20778.
178 Histamine augments beta2-adrenoceptor-induced cyclic AMP accumulation in human prostate cancer cells DU-145 independently of known histamine receptors. Biochem Pharmacol. 2007 Mar 15;73(6):814-23. doi: 10.1016/j.bcp.2006.11.022. Epub 2006 Dec 1.
179 The psychoactive compound of Cannabis sativa, (9)-tetrahydrocannabinol (THC) inhibits the human trophoblast cell turnover. Toxicology. 2015 Aug 6;334:94-103. doi: 10.1016/j.tox.2015.06.005. Epub 2015 Jun 9.
180 Pharmacological doses of testosterone upregulated androgen receptor and 3-Beta-hydroxysteroid dehydrogenase/delta-5-delta-4 isomerase and impaired leydig cells steroidogenesis in adult rats. Toxicol Sci. 2011 Jun;121(2):397-407. doi: 10.1093/toxsci/kfr063. Epub 2011 Apr 6.
181 Trialkyltin compounds bind retinoid X receptor to alter human placental endocrine functions. Mol Endocrinol. 2005 Oct;19(10):2502-16.
182 Expression of cFABP and PPAR in trophoblast cells: effect of PPAR ligands on linoleic acid uptake and differentiation. Biochim Biophys Acta. 2005 Feb 21;1687(1-3):181-94. doi: 10.1016/j.bbalip.2004.11.017.
183 The inhibitory effects of manganese on steroidogenesis in rat primary Leydig cells by disrupting steroidogenic acute regulatory (StAR) protein expression. Toxicology. 2003 May 3;187(2-3):139-48. doi: 10.1016/s0300-483x(03)00063-5.
184 Effects of histamine H(2)-receptor antagonists on human plasma levels of calcitonin gene-related peptide, substance P and vasoactive intestinal peptide. J Pharm Pharmacol. 2002 Nov;54(11):1559-63. doi: 10.1211/002235702117.
185 Non-nutritional sweeteners effects on endothelial vascular function. Toxicol In Vitro. 2020 Feb;62:104694. doi: 10.1016/j.tiv.2019.104694. Epub 2019 Oct 23.
186 The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
187 Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92. doi: 10.1016/j.bbrc.2011.08.027. Epub 2011 Aug 16.
188 Transient receptor potential vanilloid 1-mediated expression and secretion of endothelial cell-derived calcitonin gene-related peptide. Regul Pept. 2008 Oct 9;150(1-3):66-72. doi: 10.1016/j.regpep.2008.05.007. Epub 2008 Jun 3.
189 Intriguing response to azacitidine in a patient with juvenile myelomonocytic leukemia and monosomy 7. Blood. 2009 Mar 19;113(12):2867-8. doi: 10.1182/blood-2008-12-195693.
190 17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.
191 Structure-activity relationships of trans-substituted-propenoic acid derivatives on the nicotinic acid receptor HCA2 (GPR109A). Bioorg Med Chem Lett. 2011 May 1;21(9):2736-9. doi: 10.1016/j.bmcl.2010.11.091. Epub 2010 Nov 25.
192 Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.