Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0YOXQ)

• Drug Name: SB-431542 Drug Info
• Synonyms: 301836-41-9; SB-431542; SB 431542; 4-(4-(benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1H-imidazol-2-yl)benzamide; SB431542; UNII-E1557V1V0N; CHEMBL440084; E1557V1V0N; 4-[4-(1,3-BENZODIOXOL-5-YL)-5-(2-PYRIDINYL)-1H-IMIDAZOL-2-YL]BENZAMIDE; 4-(4-(1,3-Benzodioxole-5-yl)-5-(2-pyridyl)-1H-imidazole-2-yl)benzamide; SB 431542 hydrate; C22H16N4O3; 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]benzamide; 4-(4-Benzo[1,3]dioxol-5-yl-5-pyridin-2-yl-1H-imidazol-2-yl)-benzamide

Indication

Disease Entry	ICD 11	Status	REF
Pulmonary fibrosis	CB03.4	Preclinical	[1]

• Cross-matching ID:
  PubChem CID: 4521392
  ChEBI ID: CHEBI:91108
  CAS Number: CAS 301836-41-9
  TTD Drug ID: DM0YOXQ

Molecule-Related Drug Atlas

Drug(s) Targeting TGF-beta receptor type I (TGFBR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
LY2157299	DMP8HW1	Arteriosclerosis	BD40	Phase 2/3	[4]
TEW-7197	DM2LBC3	Myeloproliferative neoplasm	2A20	Phase 2	[5]
Metelimumab	DMENFD6	Scleroderma	4A42	Phase 1/2	[6]
TP-0184	DMJVZBC	Solid tumour/cancer	2A00-2F9Z	Phase 1	[7]
P-2745	DMJ3PNS	Chronic myelogenous leukaemia	2A20.0	Phase 1	[8]
LY3200882	DMQP6VB	Solid tumour/cancer	2A00-2F9Z	Phase 1	[9]
PF-06952229	DMDQJEZ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[10]
SM-16	DMHXJV2	Fibrosis	GA14-GC01	Terminated	[11]
LF-984	DMIYMS2	Fibrosis	GA14-GC01	Terminated	[12]
PMID23639540C13d	DMSTQGH	Discovery agent	N.A.	Investigative	[13]

Drug(s) Affected By Membrane-associated progesterone receptor component 1 (PGRMC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[15]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[20]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[22]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[23]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[24]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[25]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[26]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[27]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[28]
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[24]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[30]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[31]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[30]

Drug(s) Affected By Protein lin-7 homolog A (LIN7A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[33]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[33]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[36]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[37]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[38]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[39]

Drug(s) Affected By T-box transcription factor T (TBXT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[43]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[41]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[44]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[45]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[46]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[43]

Drug(s) Affected By RNA-binding protein Musashi homolog 1 (MSI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[47]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[49]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[43]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[47]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[50]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[51]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[52]

Drug(s) Affected By Prominin-1 (PROM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[53]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[54]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[55]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[58]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[59]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[60]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[61]

Drug(s) Affected By Catenin delta-1 (CTNND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[62]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[63]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[31]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]

Drug(s) Affected By AP-2 complex subunit alpha-2 (AP2A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[69]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[20]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[71]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[72]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[69]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[52]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[73]

Drug(s) Affected By Tight junction protein ZO-3 (TJP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[74]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[75]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[33]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[76]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[77]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[77]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[71]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]

Drug(s) Affected By AP-2 complex subunit alpha-1 (AP2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Bortezomib	DMNO38U	Leukemia		Approved	[78]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[71]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[79]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[80]

Drug(s) Affected By Serine/threonine-protein kinase PAK 4 (PAK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[69]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[81]
G1	DMTV42K	Lymphoma	2A80-2A86	Phase 1/2	[82]
PF-3758309	DM36PKZ	Solid tumour/cancer	2A00-2F9Z	Phase 1	[83]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[52]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[73]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[14]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[14]
taurine	DMVW7N3	Discovery agent	N.A.	Investigative	[84]

Drug(s) Affected By Urokinase-type plasminogen activator (PLAU)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[85]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[31]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[87]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[88]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[85]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[89]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[34]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[90]

Drug(s) Affected By Transferrin receptor protein 1 (TFRC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[91]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[92]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[94]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[95]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[15]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[97]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[98]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[99]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Selenium	DM25CGV	N. A.	N. A.	Approved	[101]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[103]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[104]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[105]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[95]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[106]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[107]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[108]

Drug(s) Affected By Keratin, type II cytoskeletal 1 (KRT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[111]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[112]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[113]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[111]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[114]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]

Drug(s) Affected By Guanine nucleotide-binding protein G(i) subunit alpha-2 (GNAI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[116]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[22]

Drug(s) Affected By Integrin beta-1 (ITGB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[26]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[117]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[91]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[118]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[119]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[120]
Fructose	DM43AN2	Vomiting	MD90	Approved	[121]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[88]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[122]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[123]

Drug(s) Affected By Keratin, type I cytoskeletal 18 (KRT18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[117]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[62]
Selenium	DM25CGV	N. A.	N. A.	Approved	[69]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[124]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[125]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[127]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[48]

Drug(s) Affected By Keratin, type II cytoskeletal 8 (KRT8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[117]
Selenium	DM25CGV	N. A.	N. A.	Approved	[69]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[125]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[128]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[87]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[117]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[112]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]

Drug(s) Affected By Glutathione peroxidase 1 (GPX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[130]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Amlexanox	DM0DQM5	Respiratory tract inflammation	CA07	Approved	[131]
Selenium	DM25CGV	N. A.	N. A.	Approved	[132]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[133]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[134]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[135]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[137]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[138]

Drug(s) Affected By Tyrosine-protein kinase Lyn (LYN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[15]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[141]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[59]

Drug(s) Affected By Tyrosine-protein kinase HCK (HCK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[47]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[140]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[48]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[143]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[144]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[20]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[145]
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[146]

Drug(s) Affected By Keratin, type I cytoskeletal 19 (KRT19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[117]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[147]
Selenium	DM25CGV	N. A.	N. A.	Approved	[69]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[148]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[149]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[48]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[150]

Drug(s) Affected By Keratin, type II cytoskeletal 7 (KRT7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[117]
Selenium	DM25CGV	N. A.	N. A.	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[129]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[37]

Drug(s) Affected By Guanine nucleotide-binding protein G(i) subunit alpha-3 (GNAI3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[129]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[152]
Bortezomib	DMNO38U	Leukemia		Approved	[78]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[153]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[22]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[154]

Drug(s) Affected By Tyrosine-protein kinase Fgr (FGR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[47]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[155]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[140]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[156]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[150]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[143]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[157]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[20]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[81]

Drug(s) Affected By Chorionic somatomammotropin hormone 1 (CSH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[155]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[158]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[159]
Forskolin	DM6ITNG	Solid tumour/cancer	2A00-2F9Z	Investigative	[160]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[161]

Drug(s) Affected By Choriogonadotropin subunit beta 3 (CGB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[47]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[162]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[163]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[164]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[165]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[164]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Bezafibrate	DMZDCS0	Hypercholesterolaemia	5C80.0	Approved	[166]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[167]

Drug(s) Affected By Laminin subunit gamma-1 (LAMC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[47]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[15]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[168]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[152]
Indomethacin	DMSC4A7	Bursitis		Approved	[169]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[66]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[170]

Drug(s) Affected By Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[171]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[172]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[173]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[174]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[173]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[31]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[173]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[55]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[173]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[175]

Drug(s) Affected By Keratin, type I cytoskeletal 13 (KRT13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[120]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[129]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[149]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[177]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[145]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[178]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[179]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[45]

Drug(s) Affected By Keratin, type II cytoskeletal 5 (KRT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[111]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[180]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[181]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[111]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[182]

Drug(s) Affected By CD59 glycoprotein (CD59)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[26]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[183]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[184]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[33]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]

Drug(s) Affected By 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[62]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[15]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[33]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[33]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[185]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[186]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[187]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[188]
Hexachlorophene	DMLKSE0	Bacterial infection	1A00-1C4Z	Approved	[189]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[190]

Drug(s) Affected By Glial fibrillary acidic protein (GFAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillin V	DMKVOYF	Acute otitis media	AB00	Approved	[72]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[191]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[192]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[193]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[194]
Haloperidol	DM96SE0	Delirium		Approved	[195]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[158]

Drug(s) Affected By Macrophage migration inhibitory factor (MIF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[196]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[197]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[136]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[198]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[199]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[195]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[152]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]

Drug(s) Affected By Junction plakoglobin (JUP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[200]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[14]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[201]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]

Drug(s) Affected By Desmoplakin (DSP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[129]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[70]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[48]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[34]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[202]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[203]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[22]

Drug(s) Affected By Platelet endothelial cell adhesion molecule (PECAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[204]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[205]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[206]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[207]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[208]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[209]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[210]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[211]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[212]

Drug(s) Affected By Epithelial cell adhesion molecule (EPCAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[56]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[213]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[152]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[214]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[215]

Drug(s) Affected By Midkine (MDK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[69]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[55]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[87]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[216]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[217]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[152]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[218]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[219]

Drug(s) Affected By Cadherin-3 (CDH3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[118]
Selenium	DM25CGV	N. A.	N. A.	Approved	[69]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[95]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[70]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[95]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[58]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[220]

Drug(s) Affected By Sterol carrier protein 2 (SCP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[221]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[158]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[222]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[223]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[221]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[39]

Drug(s) Affected By Integrin alpha-6 (ITGA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[224]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[225]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[226]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[96]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[227]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[228]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[229]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[230]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[231]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[232]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[233]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[234]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[235]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[236]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[237]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[238]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[239]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[230]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[240]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[241]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[242]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[229]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[72]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[26]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[232]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[233]

Drug(s) Affected By Myristoylated alanine-rich C-kinase substrate (MARCKS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[69]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[102]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[243]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[129]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[194]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]

Drug(s) Affected By Peroxiredoxin-6 (PRDX6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[244]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[106]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[245]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[158]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[246]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[218]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[247]

Drug(s) Affected By Enoyl-CoA hydratase, mitochondrial (ECHS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[248]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[198]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[249]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[250]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[251]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[252]

Drug(s) Affected By Heme oxygenase 2 (HMOX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[253]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[254]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[113]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[255]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[256]
Abexinostat	DM91LGU	Follicular lymphoma	2A80	Phase 3	[257]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[52]

Drug(s) Affected By Catenin alpha-1 (CTNNA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[118]
Selenium	DM25CGV	N. A.	N. A.	Approved	[69]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[31]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[226]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[141]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[155]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[141]
Haloperidol	DM96SE0	Delirium		Approved	[195]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]

Drug(s) Affected By Basigin (BSG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[258]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[119]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[55]
Carfilzomib	DM48K0X	Multiple myeloma	2A83	Approved	[258]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[15]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[259]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[258]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[195]

Drug(s) Affected By Vascular endothelial growth factor receptor 2 (KDR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[260]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[206]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[261]
Haloperidol	DM96SE0	Delirium		Approved	[195]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[195]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[262]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[263]

Drug(s) Affected By Trifunctional enzyme subunit alpha, mitochondrial (HADHA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[69]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[248]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[223]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[116]
Bortezomib	DMNO38U	Leukemia		Approved	[78]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[69]

Drug(s) Affected By Nestin (NES)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[151]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[264]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[265]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[266]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[195]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[152]

Drug(s) Affected By Very long-chain specific acyl-CoA dehydrogenase, mitochondrial (ACADVL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[195]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[248]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[267]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[88]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[15]
Haloperidol	DM96SE0	Delirium		Approved	[195]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[250]

Drug(s) Affected By Presenilin-1 (PSEN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[268]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[269]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[262]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[217]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[38]
Bortezomib	DMNO38U	Leukemia		Approved	[78]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[270]

Drug(s) Affected By Basal cell adhesion molecule (BCAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[55]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[271]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[22]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[272]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[272]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[52]

Drug(s) Affected By Ras-related protein Rab-13 (RAB13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[254]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[273]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[273]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[274]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[272]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[73]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[275]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[161]

Drug(s) Affected By Tyrosine-protein kinase Blk (BLK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[194]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[262]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[152]
Bortezomib	DMNO38U	Leukemia		Approved	[78]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[276]
Rigosertib	DMOSTXF	Myelodysplastic syndrome	2A37	Phase 3	[277]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[159]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[52]
PMID25656651-Compound-5	DMAI95U	Chronic myeloid leukaemia	2A20	Patented	[278]

Drug(s) Affected By Ephrin-B2 (EFNB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[279]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[33]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[280]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[58]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[59]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]

Drug(s) Affected By Ephrin type-B receptor 4 (EPHB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[281]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[142]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[143]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[152]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Omacetaxine mepesuccinate	DMPU2WX	Adult acute monocytic leukemia		Approved	[282]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[283]

Drug(s) Affected By Ephrin type-A receptor 4 (EPHA4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[284]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[285]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[284]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[70]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[194]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Mestranol	DMG3F94	Contraception	QA21	Approved	[284]

Drug(s) Affected By Trifunctional enzyme subunit beta, mitochondrial (HADHB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[248]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[195]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[195]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[250]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[223]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[21]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[22]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[286]

Drug(s) Affected By Integrin alpha-1 (ITGA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[287]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[34]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[59]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[288]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[22]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[289]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[290]

Drug(s) Affected By T-box transcription factor TBX4 (TBX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[34]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[38]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[51]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[51]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[51]

Drug(s) Affected By Cell division control protein 42 homolog (CDC42)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[88]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[254]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[291]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[213]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[292]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[293]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[294]
Bortezomib	DMNO38U	Leukemia		Approved	[78]

Drug(s) Affected By Guanine nucleotide-binding protein G(i) subunit alpha-1 (GNAI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[295]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[55]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[295]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[296]

Drug(s) Affected By Hemoglobin subunit beta (HBB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[297]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[298]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[254]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[299]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Voxelotor	DMCS6M5	Sickle-cell disorder	3A51	Approved	[300]
Ibrutinib	DMHZCPO	Mantle cell lymphoma	2A85.5	Approved	[301]
Flucloxacillin	DMNUWST	Bacterial infection	1A00-1C4Z	Approved	[302]
Capecitabine	DMTS85L	Adenocarcinoma	2D40	Approved	[303]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[304]

Drug(s) Affected By Coxsackievirus and adenovirus receptor (CXADR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[33]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[280]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[305]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[305]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[71]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[39]

Drug(s) Affected By Dermcidin (DCD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[306]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[195]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[195]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[52]

Drug(s) Affected By Pregnancy-specific beta-1-glycoprotein 9 (PSG9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[71]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[307]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[52]

Drug(s) Affected By Keratin, type I cytoskeletal 17 (KRT17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[308]
Selenium	DM25CGV	N. A.	N. A.	Approved	[69]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[111]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[111]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[308]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[111]

Drug(s) Affected By 3-ketodihydrosphingosine reductase (KDSR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[309]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[41]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[178]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[256]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[73]

Drug(s) Affected By Tight junction protein ZO-1 (TJP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[310]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[118]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[74]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[55]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[41]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[311]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[312]

Drug(s) Affected By AP-1 complex subunit beta-1 (AP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[313]
Selenium	DM25CGV	N. A.	N. A.	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[158]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[71]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[274]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[79]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[314]

Drug(s) Affected By Interleukin enhancer-binding factor 3 (ILF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[87]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[47]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[20]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[170]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[270]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[185]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[47]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[315]

Drug(s) Affected By Inactive tyrosine-protein kinase 7 (PTK7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[195]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[152]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[81]
Seocalcitol	DMKL9QO	Rickets	5B57	Phase 3	[316]

Drug(s) Affected By CD166 antigen (ALCAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[26]
Selenium	DM25CGV	N. A.	N. A.	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[15]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[317]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[152]

Drug(s) Affected By Desmoglein-2 (DSG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[168]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[152]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[20]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[274]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[290]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[68]

Drug(s) Affected By Malectin (MLEC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[69]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[318]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[71]

Drug(s) Affected By Oligodendrocyte transcription factor 3 (OLIG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[319]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[319]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[319]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[319]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[319]
Ramelteon	DM7IW9J	Insomnia	7A00-7A0Z	Approved	[319]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[320]
Dabigatran	DMDI6R4	Stroke	8B20	Approved	[319]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[321]
Abacavir	DMMN36E	Human immunodeficiency virus infection	1C62	Approved	[319]

Drug(s) Affected By Keratin, type II cytoskeletal 1b (KRT77)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[290]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[315]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[52]

Drug(s) Affected By Patatin-like phospholipase domain-containing protein 6 (PNPLA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[254]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[194]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[150]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[150]
Isoflurophate	DMBSK7X	Glaucoma/ocular hypertension	9C61	Approved	[322]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[152]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[113]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[71]

Drug(s) Affected By Protein PALS1 (PALS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[254]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[323]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[152]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[71]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[81]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[73]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[14]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[324]

Drug(s) Affected By SERPINE1 mRNA-binding protein 1 (SERBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[47]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[254]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[20]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[66]

Drug(s) Affected By Glutathione peroxidase 7 (GPX7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[325]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[185]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[256]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[185]

Drug(s) Affected By Plakophilin-4 (PKP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[47]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[33]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[59]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Indomethacin	DMSC4A7	Bursitis		Approved	[326]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[22]

Drug(s) Affected By Homeobox protein CDX-2 (CDX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[327]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[328]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[329]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[330]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[45]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[52]
OXYRESVERATROL	DMN7S4L	Discovery agent	N.A.	Investigative	[331]

Drug(s) Affected By 3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[195]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[332]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[333]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[270]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[334]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[335]

Drug(s) Affected By Plakophilin-2 (PKP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[226]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[149]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[33]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[33]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[152]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[116]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]

Drug(s) Affected By Cell adhesion molecule 1 (CADM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[31]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[47]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[336]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[337]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[152]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[61]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[338]

Drug(s) Affected By Semaphorin-4C (SEMA4C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[20]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[71]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[39]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[22]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[185]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[290]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[339]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[52]

Drug(s) Affected By Tumor protein 63 (TP63)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[340]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[110]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[341]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[48]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[58]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[342]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[343]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]

Drug(s) Affected By Band 4.1-like protein 5 (EPB41L5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[37]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[152]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[333]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]

Drug(s) Affected By Adipocyte plasma membrane-associated protein (APMAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[152]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[39]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[22]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[52]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[344]
[3H]methyltrienolone	DMTSGOW	Discovery agent	N.A.	Investigative	[345]

Drug(s) Affected By Reticulon-4 (RTN4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[254]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[323]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[39]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[22]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[346]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[41]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[256]

Drug(s) Affected By Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[62]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[323]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[71]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[81]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[347]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[256]

Drug(s) Affected By ORM1-like protein 1 (ORMDL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[34]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[22]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[62]

Drug(s) Affected By Cingulin (CGN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[74]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[348]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[223]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[59]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[152]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[64]

Drug(s) Affected By Cathepsin Z (CTSZ)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[35]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[349]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[22]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[350]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[52]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[73]

Drug(s) Affected By Tight junction protein ZO-2 (TJP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[55]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[88]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[148]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[351]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[152]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[218]

Drug(s) Affected By ETS-related transcription factor Elf-5 (ELF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[149]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[352]
Promegestone	DMK4S8I	Gynecological disease	GA6Z	Approved	[353]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[354]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[355]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[52]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[161]
ORG2058	DMH1M6N	Discovery agent	N.A.	Investigative	[353]

Drug(s) Affected By Glutathione S-transferase kappa 1 (GSTK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[117]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[100]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[55]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[219]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[39]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[356]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[357]

Drug(s) Affected By Junctional adhesion molecule A (F11R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[62]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[66]
Selenium	DM25CGV	N. A.	N. A.	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[65]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[358]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[42]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[22]

Drug(s) Affected By Insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[62]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[32]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[266]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[359]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[356]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[69]

Drug(s) Affected By Gremlin-1 (GREM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[147]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[360]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[280]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[142]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[152]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[19]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[361]

Drug(s) Affected By Bone marrow stromal antigen 2 (BST2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[69]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[139]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[102]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[149]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[16]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[362]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[152]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[102]

Drug(s) Affected By Mothers against decapentaplegic homolog 2 (SMAD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[297]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[363]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[47]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[364]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[36]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[325]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[365]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[365]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[18]

Drug(s) Affected By Transcription factor SOX-17 (SOX17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[366]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[366]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[366]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[366]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[366]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[366]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[367]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[59]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[366]
Ziprasidone	DMM58JY	Bipolar disorder	6A60	Approved	[366]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
TGF-beta receptor type I (TGFBR1)	TTP4520	TGFR1_HUMAN	Inhibitor	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1)	OTNAZVKB	3BHS1_HUMAN	Gene/Protein Processing	[3]
3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10)	OT7RJON4	HCD2_HUMAN	Gene/Protein Processing	[3]
3-ketodihydrosphingosine reductase (KDSR)	OTCIES3H	KDSR_HUMAN	Gene/Protein Processing	[3]
Adipocyte plasma membrane-associated protein (APMAP)	OT1P2GJA	APMAP_HUMAN	Gene/Protein Processing	[3]
AP-1 complex subunit beta-1 (AP1B1)	OTY0K84R	AP1B1_HUMAN	Gene/Protein Processing	[3]
AP-2 complex subunit alpha-1 (AP2A1)	OTEFZB21	AP2A1_HUMAN	Gene/Protein Processing	[3]
AP-2 complex subunit alpha-2 (AP2A2)	OTD1UGUN	AP2A2_HUMAN	Gene/Protein Processing	[3]
Band 4.1-like protein 5 (EPB41L5)	OTPPQPLU	E41L5_HUMAN	Gene/Protein Processing	[3]
Basal cell adhesion molecule (BCAM)	OTHZOPSD	BCAM_HUMAN	Gene/Protein Processing	[3]
Basigin (BSG)	OTD0CVEC	BASI_HUMAN	Gene/Protein Processing	[3]

References

• [1] Drugs and Targets in Fibrosis. Front Pharmacol. 2017 Nov 23;8:855.
• [2] Pyrazolone based TGFbetaR1 kinase inhibitors. Bioorg Med Chem Lett. 2010 Jan 1;20(1):326-9.
• [3] Activin/nodal signaling switches the terminal fate of human embryonic stem cell-derived trophoblasts. J Biol Chem. 2015 Apr 3;290(14):8834-48.
• [4] Cardiac Safety of TGF-beta Receptor I Kinase Inhibitor LY2157299 Monohydrate in Cancer Patients in a First-in-Human Dose Study. Cardiovasc Toxicol. 2015 Oct;15(4):309-23.
• [5] Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.
• [6] Development of TGF-beta signalling inhibitors for cancer therapy. Nat Rev Drug Discov. 2004 Dec;3(12):1011-22.
• [7] Clinical pipeline report, company report or official report of Sumitomo Dainippon Pharma.
• [8] Novel potent inhibitor of Bcr-Abl mutated imatinib resistant chronic myeloid leukemia cell lines. Cancer Research. 06/2012; 72(8 Supplement):1822-1822.
• [9] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [10] Targeting the TGF pathway for cancer therapy. Pharmacol Ther. 2015 Mar;147:22-31.
• [11] TGF-beta type I receptor kinase inhibitor down-regulates rheumatoid synoviocytes and prevents the arthritis induced by type II collagen antibody. Int Immunol. 2007 Feb;19(2):117-26.
• [12] US patent application no. 2013,0028,978, Compositions and methods for wound treatment.
• [13] Synthesis and structure-activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of dorsomorphin: the discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3248-52.
• [14] Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
• [15] Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
• [16] Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
• [17] Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
• [18] Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
• [19] Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
• [20] Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
• [21] Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
• [22] Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
• [23] Identification of protein expression alterations in gefitinib-resistant human lung adenocarcinoma: PCNT and mPR play key roles in the development of gefitinib-associated resistance. Toxicol Appl Pharmacol. 2015 Nov 1;288(3):359-73. doi: 10.1016/j.taap.2015.08.008. Epub 2015 Aug 20.
• [24] Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity. Toxicology. 2014 Jan 6;315:8-16. doi: 10.1016/j.tox.2013.10.009. Epub 2013 Nov 6.
• [25] Regulation of DR-5 protein and mitochondrial transmembrane potential by gemcitabine, a possible mechanism of gemcitabine-enhanced TRAIL-induced apoptosis. Oncol Rep. 2007 Sep;18(3):523-9.
• [26] Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
• [27] Amiodarone sensitizes human glioma cells but not astrocytes to TRAIL-induced apoptosis via CHOP-mediated DR5 upregulation. Neuro Oncol. 2011 Mar;13(3):267-79. doi: 10.1093/neuonc/noq195. Epub 2011 Feb 3.
• [28] Novel functional view of the crocidolite asbestos-treated A549 human lung epithelial transcriptome reveals an intricate network of pathways with opposing functions. BMC Genomics. 2008 Aug 7;9:376.
• [29] Death receptor 5 regulation during selenium-mediated apoptosis in human prostate cancer cells. Cancer Biol Ther. 2002 May-Jun;1(3):287-90. doi: 10.4161/cbt.83.
• [30] Death receptor regulation and celecoxib-induced apoptosis in human lung cancer cells. J Natl Cancer Inst. 2004 Dec 1;96(23):1769-80. doi: 10.1093/jnci/djh322.
• [31] Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
• [32] Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
• [33] Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
• [34] Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
• [35] Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
• [36] A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
• [37] Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
• [38] Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons. PLoS One. 2009 Sep 23;4(9):e7155.
• [39] Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
• [40] Molecular characterization of a toxicological tipping point during human stem cell differentiation. Reprod Toxicol. 2020 Jan;91:1-13. doi: 10.1016/j.reprotox.2019.10.001. Epub 2019 Oct 7.
• [41] Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
• [42] Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
• [43] Bisphenol A Represses Dopaminergic Neuron Differentiation from Human Embryonic Stem Cells through Downregulating the Expression of Insulin-like Growth Factor 1. Mol Neurobiol. 2017 Jul;54(5):3798-3812. doi: 10.1007/s12035-016-9898-y. Epub 2016 Jun 7.
• [44] Gene expression levels in normal human lymphoblasts with variable sensitivities to arsenite: identification of GGT1 and NFKBIE expression levels as possible biomarkers of susceptibility. Toxicol Appl Pharmacol. 2008 Jan 15;226(2):199-205. doi: 10.1016/j.taap.2007.09.004. Epub 2007 Sep 15.
• [45] CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.
• [46] A human embryonic stem cell-based model for benzo[a]pyrene-induced embryotoxicity. Reprod Toxicol. 2019 Apr;85:26-33. doi: 10.1016/j.reprotox.2019.01.008. Epub 2019 Jan 16.
• [47] Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
• [48] Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
• [49] DNA methylation inhibits p53-mediated survivin repression. Oncogene. 2009 May 14;28(19):2046-50. doi: 10.1038/onc.2009.62. Epub 2009 Apr 13.
• [50] Resveratrol promotes proteasome-dependent degradation of Nanog via p53 activation and induces differentiation of glioma stem cells. Stem Cell Res. 2013 Jul;11(1):601-10. doi: 10.1016/j.scr.2013.04.004. Epub 2013 Apr 11.
• [51] Comprehensive transcriptome profiling of BET inhibitor-treated HepG2 cells. PLoS One. 2022 Apr 29;17(4):e0266966. doi: 10.1371/journal.pone.0266966. eCollection 2022.
• [52] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
• [53] Ciprofloxacin mediates cancer stem cell phenotypes in lung cancer cells through caveolin-1-dependent mechanism. Chem Biol Interact. 2016 Apr 25;250:1-11.
• [54] Actinomycin D inhibits the expression of the cystine/glutamate transporter xCT via attenuation of CD133 synthesis in CD133(+) HCC. Chem Biol Interact. 2019 Aug 25;309:108713. doi: 10.1016/j.cbi.2019.06.026. Epub 2019 Jun 19.
• [55] Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
• [56] Enhancement of the antiproliferative activity of gemcitabine by modulation of c-Met pathway in pancreatic cancer. Curr Pharm Des. 2013;19(5):940-50.
• [57] Arsenic oxide targets stem cell marker CD133/prominin-1 in gallbladder carcinoma. Cancer Lett. 2011 Nov 28;310(2):181-7. doi: 10.1016/j.canlet.2011.06.035. Epub 2011 Jul 5.
• [58] Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells. Chem Res Toxicol. 2014 Mar 17;27(3):408-20.
• [59] Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
• [60] Melatonin reduces lung cancer stemness through inhibiting of PLC, ERK, p38, -catenin, and Twist pathways. Environ Toxicol. 2019 Feb;34(2):203-209. doi: 10.1002/tox.22674. Epub 2018 Nov 12.
• [61] A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo. Carcinogenesis. 2012 Jul;33(7):1421-9.
• [62] DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
• [63] PGK1 induction by a hydrogen peroxide treatment is suppressed by antioxidants in human colon carcinoma cells. Biosci Biotechnol Biochem. 2008 Jul;72(7):1799-808. doi: 10.1271/bbb.80079. Epub 2008 Jul 7.
• [64] Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
• [65] Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
• [66] Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
• [67] Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
• [68] The NRF2-mediated oxidative stress response pathway is associated with tumor cell resistance to arsenic trioxide across the NCI-60 panel. BMC Med Genomics. 2010 Aug 13;3:37. doi: 10.1186/1755-8794-3-37.
• [69] Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
• [70] THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
• [71] Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
• [72] ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
• [73] Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
• [74] Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
• [75] Gene microarray analysis of human renal cell carcinoma: the effects of HDAC inhibition and retinoid treatment. Cancer Biol Ther. 2008 Oct;7(10):1607-18.
• [76] Evidence for a role of claudin 2 as a proximal tubular stress responsive paracellular water channel. Toxicol Appl Pharmacol. 2014 Sep 1;279(2):163-72.
• [77] Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. PLoS One. 2012;7(12):e53003. doi: 10.1371/journal.pone.0053003. Epub 2012 Dec 27.
• [78] The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
• [79] Proteomic analysis of the cellular response to a potent sensitiser unveils the dynamics of haptenation in living cells. Toxicology. 2020 Dec 1;445:152603. doi: 10.1016/j.tox.2020.152603. Epub 2020 Sep 28.
• [80] Alternatives for the worse: Molecular insights into adverse effects of bisphenol a and substitutes during human adipocyte differentiation. Environ Int. 2021 Nov;156:106730. doi: 10.1016/j.envint.2021.106730. Epub 2021 Jun 27.
• [81] Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
• [82] The G Protein-Coupled Estrogen Receptor Agonist G-1 Inhibits Nuclear Estrogen Receptor Activity and Stimulates Novel Phosphoproteomic Signatures. Toxicol Sci. 2016 Jun;151(2):434-46. doi: 10.1093/toxsci/kfw057. Epub 2016 Mar 29.
• [83] Inhibition of neuroblastoma proliferation by PF-3758309, a small-molecule inhibitor that targets p21-activated kinase 4. Oncol Rep. 2017 Nov;38(5):2705-2716. doi: 10.3892/or.2017.5989. Epub 2017 Sep 22.
• [84] Taurine-responsive genes related to signal transduction as identified by cDNA microarray analyses of HepG2 cells. J Med Food. 2006 Spring;9(1):33-41. doi: 10.1089/jmf.2006.9.33.
• [85] Genomic profiling uncovers a molecular pattern for toxicological characterization of mutagens and promutagens in vitro. Toxicol Sci. 2011 Jul;122(1):185-97.
• [86] Quercetin inhibits invasion, migration and signalling molecules involved in cell survival and proliferation of prostate cancer cell line (PC-3). Cell Biochem Funct. 2011 Mar;29(2):87-95. doi: 10.1002/cbf.1725. Epub 2011 Feb 9.
• [87] Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
• [88] Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
• [89] Arsenic trioxide (As2O3) inhibits invasion of HT1080 human fibrosarcoma cells: role of nuclear factor-kappaB and reactive oxygen species. J Cell Biochem. 2005 Aug 1;95(5):955-69. doi: 10.1002/jcb.20452.
• [90] Atorvastatin affects several angiogenic mediators in human endothelial cells. Endothelium. 2005 Sep-Dec;12(5-6):233-41.
• [91] Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res. 2002 Aug 1;62(15):4419-26.
• [92] Relationships and distinctions in iron-regulatory networks responding to interrelated signals. Blood. 2003 May 1;101(9):3690-8. doi: 10.1182/blood-2002-07-2140. Epub 2002 Sep 26.
• [93] Differential effects of statins on relevant functions of human monocyte-derived dendritic cells. J Leukoc Biol. 2006 Mar;79(3):529-38. doi: 10.1189/jlb.0205064. Epub 2005 Dec 30.
• [94] Quantitative proteomic analysis of HepG2 cells treated with quercetin suggests IQGAP1 involved in quercetin-induced regulation of cell proliferation and migration. OMICS. 2009 Apr;13(2):93-103. doi: 10.1089/omi.2008.0075.
• [95] Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
• [96] Retinoic acid-induced downmodulation of telomerase activity in human cancer cells. Exp Mol Pathol. 2005 Oct;79(2):108-17.
• [97] Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
• [98] Arsenic trioxide induces apoptosis of human monocytes during macrophagic differentiation through nuclear factor-kappaB-related survival pathway down-regulation. J Pharmacol Exp Ther. 2006 Jan;316(1):304-14. doi: 10.1124/jpet.105.092874. Epub 2005 Sep 20.
• [99] Phenolic metabolites of benzene inhibited the erythroid differentiation of K562 cells. Toxicol Lett. 2011 Jun 24;203(3):190-9. doi: 10.1016/j.toxlet.2011.03.012. Epub 2011 Mar 23.
• [100] Neuroprotective effects of glucomoringin-isothiocyanate against H(2)O(2)-Induced cytotoxicity in neuroblastoma (SH-SY5Y) cells. Neurotoxicology. 2019 Dec;75:89-104. doi: 10.1016/j.neuro.2019.09.008. Epub 2019 Sep 12.
• [101] Changes in gene expression profiles in response to selenium supplementation among individuals with arsenic-induced pre-malignant skin lesions. Toxicol Lett. 2007 Mar 8;169(2):162-76. doi: 10.1016/j.toxlet.2007.01.006. Epub 2007 Jan 19.
• [102] Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
• [103] P450 3A-catalyzed O-dealkylation of lapatinib induces mitochondrial stress and activates Nrf2. Chem Res Toxicol. 2016 May 16;29(5):784-96.
• [104] Epinephrine upregulates superoxide dismutase in human coronary artery endothelial cells. Free Radic Biol Med. 2001 Jan 15;30(2):148-53.
• [105] Cissus quadrangularis ethanol extract upregulates superoxide dismutase, glutathione peroxidase and endothelial nitric oxide synthase expression in hydrogen peroxide-injured human ECV304 cells. J Ethnopharmacol. 2012 Sep 28;143(2):664-72.
• [106] Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
• [107] Manganese superoxide dismutase is a promising target for enhancing chemosensitivity of basal-like breast carcinoma. Antioxid Redox Signal. 2014 May 20;20(15):2326-46. doi: 10.1089/ars.2013.5295. Epub 2013 Nov 14.
• [108] Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4050-61.
• [109] Differential protein expression of peroxiredoxin I and II by benzo(a)pyrene and quercetin treatment in 22Rv1 and PrEC prostate cell lines. Toxicol Appl Pharmacol. 2007 Apr 15;220(2):197-210. doi: 10.1016/j.taap.2006.12.030. Epub 2007 Jan 9.
• [110] Activation of PPAR and inhibition of cell proliferation reduces key proteins associated with the basal subtype of bladder cancer in As3+-transformed UROtsa cells. PLoS One. 2020 Aug 21;15(8):e0237976. doi: 10.1371/journal.pone.0237976. eCollection 2020.
• [111] Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
• [112] Proteomics investigations of drug-induced hepatotoxicity in HepG2 cells. Toxicol Sci. 2011 Mar;120(1):109-22.
• [113] CXCL14 downregulation in human keratinocytes is a potential biomarker for a novel in vitro skin sensitization test. Toxicol Appl Pharmacol. 2020 Jan 1;386:114828. doi: 10.1016/j.taap.2019.114828. Epub 2019 Nov 14.
• [114] Application of cDNA microarray to the study of arsenic-induced liver diseases in the population of Guizhou, China. Toxicol Sci. 2001 Jan;59(1):185-92.
• [115] Propofol suppresses proliferation, migration, invasion, and tumor growth of liver cancer cells via suppressing cancer susceptibility candidate 9/phosphatase and tensin homolog/AKT serine/threonine kinase/mechanistic target of rapamycin kinase axis. Hum Exp Toxicol. 2022 Jan-Dec;41:9603271211065972. doi: 10.1177/09603271211065972.
• [116] Identification of biomarkers and outcomes of endocrine disruption in human ovarian cortex using In Vitro Models. Toxicology. 2023 Feb;485:153425. doi: 10.1016/j.tox.2023.153425. Epub 2023 Jan 5.
• [117] Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
• [118] Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
• [119] Distinct genetic profile in peripheral blood mononuclear cells of psoriatic arthritis patients treated with methotrexate and TNF-inhibitors. Clin Rheumatol. 2014 Dec;33(12):1815-21. doi: 10.1007/s10067-014-2807-8. Epub 2014 Oct 24.
• [120] Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer Sci. 2007 Jun;98(6):890-9.
• [121] Non-nutritional sweeteners effects on endothelial vascular function. Toxicol In Vitro. 2020 Feb;62:104694. doi: 10.1016/j.tiv.2019.104694. Epub 2019 Oct 23.
• [122] Regulation of epithelial cell morphology and functions approaching to more in vivo-like by modifying polyethylene glycol on polysulfone membranes. PLoS One. 2012;7(4):e36110.
• [123] Gene expression profile changes in NB4 cells induced by arsenic trioxide. Acta Pharmacol Sin. 2003 Jul;24(7):646-50.
• [124] The stability of cytokeratin 18 in human liver cells during colchicine-induced microtubule disruption. Food Chem Toxicol. 2001 Jan;39(1):85-9. doi: 10.1016/s0278-6915(00)00113-7.
• [125] Proteomic identification of differentially expressed proteins associated with the multiple drug resistance in methotrexate-resistant human breast cancer cells. Int J Oncol. 2014 Jul;45(1):448-58.
• [126] Identification of biomarkers for the initiation of apoptosis in human preneoplastic colonocytes by proteome analysis. Int J Cancer. 2004 Mar 20;109(2):220-9. doi: 10.1002/ijc.11692.
• [127] Nevirapine restores androgen signaling in hormone-refractory human prostate carcinoma cells both in vitro and in vivo. Prostate. 2009 May 15;69(7):744-54. doi: 10.1002/pros.20923.
• [128] The effects of quercetin on SW480 human colon carcinoma cells: a proteomic study. Nutr J. 2005 Mar 4;4:11.
• [129] Proteomics-based identification of differentially abundant proteins from human keratinocytes exposed to arsenic trioxide. J Proteomics Bioinform. 2014 Jul;7(7):166-178.
• [130] Chromium III histidinate exposure modulates gene expression in HaCaT human keratinocytes exposed to oxidative stress. Biol Trace Elem Res. 2010 Oct;137(1):23-39.
• [131] Premature termination codon readthrough in human cells occurs in novel cytoplasmic foci and requires UPF proteins. J Cell Sci. 2017 Sep 15;130(18):3009-3022. doi: 10.1242/jcs.198176. Epub 2017 Jul 25.
• [132] Effects of Se-depletion on glutathione peroxidase and selenoprotein W gene expression in the colon. FEBS Lett. 2005 Jan 31;579(3):792-6. doi: 10.1016/j.febslet.2004.12.042.
• [133] Methotrexate-related response on human peripheral blood mononuclear cells may be modulated by the Ala16Val-SOD2 gene polymorphism. PLoS One. 2014 Oct 20;9(10):e107299. doi: 10.1371/journal.pone.0107299. eCollection 2014.
• [134] A high-throughput reporter gene assay to prove the ability of natural compounds to modulate glutathione peroxidase, superoxide dismutase and catalase gene promoters in V79 cells. Free Radic Res. 2008 Aug;42(8):746-53.
• [135] Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model. Toxicol In Vitro. 2009 Oct;23(7):1387-95.
• [136] Pharmacogenomic analysis of acute promyelocytic leukemia cells highlights CYP26 cytochrome metabolism in differential all-trans retinoic acid sensitivity. Blood. 2007 May 15;109(10):4450-60.
• [137] Role of oxidative stress in the apoptosis of hepatocellular carcinoma induced by combination of arsenic trioxide and ascorbic acid. Acta Pharmacol Sin. 2006 Aug;27(8):1078-84.
• [138] Involvement of oxidative stress in the impairment in biliary secretory function induced by intraperitoneal administration of aluminum to rats. Biol Trace Elem Res. 2007 Jun;116(3):329-48.
• [139] Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
• [140] Expression profile analysis of human peripheral blood mononuclear cells in response to aspirin. Arch Immunol Ther Exp (Warsz). 2005 Mar-Apr;53(2):151-8.
• [141] Comparison of the gene expression profiles of monocytic versus granulocytic lineages of HL-60 leukemia cell differentiation by DNA microarray analysis. Life Sci. 2003 Aug 15;73(13):1705-19. doi: 10.1016/s0024-3205(03)00515-0.
• [142] Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
• [143] The effects of dasatinib on IgE receptor-dependent activation and histamine release in human basophils. Blood. 2008 Mar 15;111(6):3097-107.
• [144] Aberrant DNA methylation of the Src kinase Hck, but not of Lyn, in Philadelphia chromosome negative acute lymphocytic leukemia. Leukemia. 2007 May;21(5):906-11. doi: 10.1038/sj.leu.2404615. Epub 2007 Mar 8.
• [145] 17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.
• [146] Selective targeting of the inactive state of hematopoietic cell kinase (Hck) with a stable curcumin derivative. J Biol Chem. 2021 Jan-Jun;296:100449. doi: 10.1016/j.jbc.2021.100449. Epub 2021 Feb 20.
• [147] Unique signatures of stress-induced senescent human astrocytes. Exp Neurol. 2020 Dec;334:113466. doi: 10.1016/j.expneurol.2020.113466. Epub 2020 Sep 17.
• [148] Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. Arch Toxicol. 2016 Jan;90(1):159-80.
• [149] Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
• [150] Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
• [151] Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
• [152] Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
• [153] High levels of caveolar cholesterol inhibit progesterone-induced genomic actions in human and guinea pig gallbladder muscle. Am J Physiol Gastrointest Liver Physiol. 2009 Apr;296(4):G948-54. doi: 10.1152/ajpgi.90699.2008. Epub 2009 Feb 12.
• [154] Effect of aflatoxin B(1), benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells. Food Chem Toxicol. 2018 Nov;121:214-223. doi: 10.1016/j.fct.2018.08.034. Epub 2018 Aug 26.
• [155] Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
• [156] Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 Feb 26;10(1):3450. doi: 10.1038/s41598-020-59827-1.
• [157] Analysis of gene expression induced by diethylstilbestrol (DES) in human primitive Mullerian duct cells using microarray. Cancer Lett. 2005 Apr 8;220(2):197-210.
• [158] Effects of acute ethanol treatment on NCCIT cells and NCCIT cell-derived embryoid bodies (EBs). Toxicol In Vitro. 2010 Sep;24(6):1696-704. doi: 10.1016/j.tiv.2010.05.017. Epub 2010 May 26.
• [159] High-throughput ectopic expression screen for tamoxifen resistance identifies an atypical kinase that blocks autophagy. Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2058-63.
• [160] Effects of selective serotonin-reuptake inhibitors (SSRIs) on human villous trophoblasts syncytialization. Toxicol Appl Pharmacol. 2018 Jun 15;349:8-20. doi: 10.1016/j.taap.2018.04.018. Epub 2018 Apr 19.
• [161] From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
• [162] The psychoactive compound of Cannabis sativa, (9)-tetrahydrocannabinol (THC) inhibits the human trophoblast cell turnover. Toxicology. 2015 Aug 6;334:94-103. doi: 10.1016/j.tox.2015.06.005. Epub 2015 Jun 9.
• [163] Pharmacological doses of testosterone upregulated androgen receptor and 3-Beta-hydroxysteroid dehydrogenase/delta-5-delta-4 isomerase and impaired leydig cells steroidogenesis in adult rats. Toxicol Sci. 2011 Jun;121(2):397-407. doi: 10.1093/toxsci/kfr063. Epub 2011 Apr 6.
• [164] Trialkyltin compounds bind retinoid X receptor to alter human placental endocrine functions. Mol Endocrinol. 2005 Oct;19(10):2502-16.
• [165] Peroxisome proliferator activated receptor gamma (PPAR-gama) ligand pioglitazone regulated gene networks in term human primary trophoblast cells. Reprod Toxicol. 2018 Oct;81:99-107.
• [166] Expression of cFABP and PPAR in trophoblast cells: effect of PPAR ligands on linoleic acid uptake and differentiation. Biochim Biophys Acta. 2005 Feb 21;1687(1-3):181-94. doi: 10.1016/j.bbalip.2004.11.017.
• [167] The inhibitory effects of manganese on steroidogenesis in rat primary Leydig cells by disrupting steroidogenic acute regulatory (StAR) protein expression. Toxicology. 2003 May 3;187(2-3):139-48. doi: 10.1016/s0300-483x(03)00063-5.
• [168] The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
• [169] The cyclooxygenase inhibitor indomethacin modulates gene expression and represses the extracellular matrix protein laminin gamma1 in human glioblastoma cells. Exp Cell Res. 2005 Jan 15;302(2):244-52. doi: 10.1016/j.yexcr.2004.09.021.
• [170] Apoptosis induced by piroxicam plus cisplatin combined treatment is triggered by p21 in mesothelioma. PLoS One. 2011;6(8):e23569.
• [171] Kinetic analysis of the liver-type (GLUT2) and brain-type (GLUT3) glucose transporters in Xenopus oocytes: substrate specificities and effects of transport inhibitors. Biochem J. 1993 Mar 15;290 ( Pt 3)(Pt 3):701-6. doi: 10.1042/bj2900701.
• [172] Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Redox Biol. 2020 Jan;28:101321. doi: 10.1016/j.redox.2019.101321. Epub 2019 Sep 5.
• [173] A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system. Toxicol Sci. 2005 Feb;83(2):282-92.
• [174] In vitro detection of drug-induced phospholipidosis using gene expression and fluorescent phospholipid based methodologies. Toxicol Sci. 2007 Sep;99(1):162-73.
• [175] Retinoic acid represses a cassette of candidate pluripotency chromosome 12p genes during induced loss of human embryonal carcinoma tumorigenicity. Biochim Biophys Acta. 2005 Oct 15;1731(1):48-56. doi: 10.1016/j.bbaexp.2005.08.006. Epub 2005 Sep 1.
• [176] Retinoic acid-induced glandular differentiation of the oesophagus. Gut. 2007 Jul;56(7):906-17. doi: 10.1136/gut.2006.097915. Epub 2006 Dec 21.
• [177] Extremely low copper concentrations affect gene expression profiles of human prostate epithelial cell lines. Chem Biol Interact. 2010 Oct 6;188(1):214-9.
• [178] cDNA microarray analysis of isogenic paclitaxel- and doxorubicin-resistant breast tumor cell lines reveals distinct drug-specific genetic signatures of resistance. Breast Cancer Res Treat. 2006 Mar;96(1):17-39. doi: 10.1007/s10549-005-9026-6. Epub 2005 Dec 2.
• [179] Gene expression preferentially regulated by tamoxifen in breast cancer cells and correlations with clinical outcome. Cancer Res. 2006 Jul 15;66(14):7334-40.
• [180] Oral lichenoid eruption secondary to imatinib (Glivec). J Dermatolog Treat. 2004 Jul;15(4):253-5. doi: 10.1080/09546630410015556.
• [181] Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound. Toxicol In Vitro. 2021 Jun;73:105112. doi: 10.1016/j.tiv.2021.105112. Epub 2021 Feb 22.
• [182] Retinoic acid receptor- and retinoid X receptor-selective retinoids activate signaling pathways that converge on AP-1 and inhibit squamous differentiation in human bronchial epithelial cells. Cell Growth Differ. 1996 Aug;7(8):997-1004.
• [183] Mechanisms of the genotoxicity of crocidolite asbestos in mammalian cells: implication from mutation patterns induced by reactive oxygen species. Environ Health Perspect. 2002 Oct;110(10):1003-8. doi: 10.1289/ehp.021101003.
• [184] Comparison of the mutagenic potential of 17 physical and chemical agents analyzed by the flow cytometry mutation assay. Mutat Res. 2006 Dec 1;602(1-2):14-25. doi: 10.1016/j.mrfmmm.2006.07.009. Epub 2006 Oct 11.
• [185] Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
• [186] Towards a systematic analysis of human short-chain dehydrogenases/reductases (SDR): Ligand identification and structure-activity relationships. Chem Biol Interact. 2015 Jun 5;234:114-25.
• [187] Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures. Arch Toxicol. 2018 Jun;92(6):1939-1952.
• [188] Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029.
• [189] The analysis of pesticides and fungicides in the inhibition of human and rat placental 3-hydroxysteroid dehydrogenase activity: Mode of inhibition and mechanism. Toxicol Lett. 2023 Apr 15;379:76-86. doi: 10.1016/j.toxlet.2023.03.002. Epub 2023 Mar 24.
• [190] Estrogenic endocrine disruptive components interfere with calcium handling and differentiation of human trophoblast cells. J Cell Biochem. 2003 Jul 1;89(4):755-70.
• [191] miRNA expression profiling in a human stem cell-based model as a tool for developmental neurotoxicity testing. Cell Biol Toxicol. 2013 Aug;29(4):239-57. doi: 10.1007/s10565-013-9250-5. Epub 2013 Aug 1.
• [192] A prominent elevation of glial fibrillary acidic protein in the cerebrospinal fluid during relapse in neuromyelitis optica. Tohoku J Exp Med. 2008 May;215(1):55-9. doi: 10.1620/tjem.215.55.
• [193] Aspirin-induced blockade of NF-kappaB activity restrains up-regulation of glial fibrillary acidic protein in human astroglial cells. Biochim Biophys Acta. 2006 Mar;1763(3):282-9. doi: 10.1016/j.bbamcr.2006.01.005. Epub 2006 Feb 21.
• [194] The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
• [195] Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
• [196] Chronic senescent human mesenchymal stem cells as possible contributor to the wound healing disorder after exposure to the alkylating agent sulfur mustard. Arch Toxicol. 2021 Feb;95(2):727-747. doi: 10.1007/s00204-020-02946-5. Epub 2021 Jan 25.
• [197] Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells. Exp Eye Res. 2009 Dec;89(6):995-1002. doi: 10.1016/j.exer.2009.08.011. Epub 2009 Sep 1.
• [198] Proteomic and functional analyses reveal a dual molecular mechanism underlying arsenic-induced apoptosis in human multiple myeloma cells. J Proteome Res. 2009 Jun;8(6):3006-19.
• [199] Folate deficiency in normal human fibroblasts leads to altered expression of genes primarily linked to cell signaling, the cytoskeleton and extracellular matrix. J Nutr Biochem. 2007 Aug;18(8):541-52. doi: 10.1016/j.jnutbio.2006.11.002. Epub 2007 Feb 22.
• [200] Convergent transcriptional profiles induced by endogenous estrogen and distinct xenoestrogens in breast cancer cells. Carcinogenesis. 2006 Aug;27(8):1567-78.
• [201] Epigenetic regulation of human trophoblastic cell migration and invasion. Endocrinology. 2006 Nov;147(11):5275-83. doi: 10.1210/en.2006-0288. Epub 2006 Aug 3.
• [202] Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells. Chem Res Toxicol. 2015 Oct 19;28(10):1903-13. doi: 10.1021/acs.chemrestox.5b00105. Epub 2015 Sep 21.
• [203] Cytosolic proteomic alterations in the nucleus accumbens of cocaine overdose victims. Mol Psychiatry. 2007 Jan;12(1):55-73. doi: 10.1038/sj.mp.4001914. Epub 2006 Oct 31.
• [204] Relationship between release of platelet/endothelial biomarkers and plasma levels of sertraline and N-desmethylsertraline in acute coronary syndrome patients receiving SSRI treatment for depression. Am J Psychiatry. 2005 Jun;162(6):1165-70. doi: 10.1176/appi.ajp.162.6.1165.
• [205] Frankincense myrrh attenuates hepatocellular carcinoma by regulating tumor blood vessel development through multiple epidermal growth factor receptor-mediated signaling pathways. World J Gastrointest Oncol. 2022 Feb 15;14(2):450-477. doi: 10.4251/wjgo.v14.i2.450.
• [206] Low dosage of arsenic trioxide (As(2)O(3)) inhibits angiogenesis in epithelial ovarian cancer without cell apoptosis. J Biol Inorg Chem. 2018 Aug;23(6):939-947. doi: 10.1007/s00775-018-1595-z. Epub 2018 Jul 16.
• [207] Effects of aspirin on metastasis-associated gene expression detected by cDNA microarray. Acta Pharmacol Sin. 2004 Oct;25(10):1327-33.
• [208] Thalidomide suppresses angiogenesis and immune evasion via lncRNA FGD5-AS1/miR-454-3p/ZEB1 axis-mediated VEGFA expression and PD-1/PD-L1 checkpoint in NSCLC. Chem Biol Interact. 2021 Nov 1;349:109652. doi: 10.1016/j.cbi.2021.109652. Epub 2021 Sep 11.
• [209] RhoA/MLC signaling pathway is involved in ?-tetrahydrocannabinol-impaired placental angiogenesis. Toxicol Lett. 2018 Mar 15;285:148-155. doi: 10.1016/j.toxlet.2017.12.031. Epub 2018 Jan 4.
• [210] Magnitude and time course of platelet inhibition with Aggrenox and Aspirin in patients after ischemic stroke: the AGgrenox versus Aspirin Therapy Evaluation (AGATE) trial. Eur J Pharmacol. 2004 Sep 24;499(3):315-24. doi: 10.1016/j.ejphar.2004.07.114.
• [211] Possible roles for folic acid in the regulation of trophoblast invasion and placental development in normal early human pregnancy. Biol Reprod. 2011 Jun;84(6):1148-53. doi: 10.1095/biolreprod.110.088351. Epub 2011 Feb 23.
• [212] Rosiglitazone impairs proliferation of human adrenocortical cancer: preclinical study in a xenograft mouse model. Endocr Relat Cancer. 2010 Feb 18;17(1):169-77. doi: 10.1677/ERC-09-0170. Print 2010 Mar.
• [213] JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Oncogene. 2008 Aug 28;27(37):5033-44.
• [214] Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell. 2009 Aug 21;138(4):645-659. doi: 10.1016/j.cell.2009.06.034. Epub 2009 Aug 13.
• [215] Methylation status of the Ep-CAM promoter region in human breast cancer cell lines and breast cancer tissue. Cancer Lett. 2007 Feb 8;246(1-2):253-61. doi: 10.1016/j.canlet.2006.03.002. Epub 2006 Apr 18.
• [216] Constitutive gene expression predisposes morphogen-mediated cell fate responses of NT2/D1 and 27X-1 human embryonal carcinoma cells. Stem Cells. 2007 Mar;25(3):771-8. doi: 10.1634/stemcells.2006-0271. Epub 2006 Nov 30.
• [217] NOTCH signaling is activated in and contributes to resistance in enzalutamide-resistant prostate cancer cells. J Biol Chem. 2019 May 24;294(21):8543-8554. doi: 10.1074/jbc.RA118.006983. Epub 2019 Apr 2.
• [218] Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
• [219] Role of phenytoin in wound healing: microarray analysis of early transcriptional responses in human dermal fibroblasts. Biochem Biophys Res Commun. 2004 Feb 13;314(3):661-6. doi: 10.1016/j.bbrc.2003.12.146.
• [220] High folic acid increases cell turnover and lowers differentiation and iron content in human HT29 colon cancer cells. Br J Nutr. 2008 Apr;99(4):703-8.
• [221] Transcriptional profiling suggests that Nevirapine and Ritonavir cause drug induced liver injury through distinct mechanisms in primary human hepatocytes. Chem Biol Interact. 2016 Aug 5;255:31-44.
• [222] Induction of the endoplasmic reticulum stress protein GADD153/CHOP by capsaicin in prostate PC-3 cells: a microarray study. Biochem Biophys Res Commun. 2008 Aug 8;372(4):785-91.
• [223] Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
• [224] Patterns of some extracellular matrix gene expression are similar in cells from cleft lip-palate patients and in human palatal fibroblasts exposed to diazepam in culture. Toxicology. 2009 Mar 4;257(1-2):10-6. doi: 10.1016/j.tox.2008.12.002. Epub 2008 Dec 9.
• [225] Gene expression profiling of rheumatoid arthritis synovial cells treated with antirheumatic drugs. J Biomol Screen. 2007 Apr;12(3):328-40. doi: 10.1177/1087057107299261. Epub 2007 Mar 22.
• [226] Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur J Nutr. 2005 Mar;44(3):143-56. doi: 10.1007/s00394-004-0503-1. Epub 2004 Apr 30.
• [227] A comprehensive analysis of Wnt/beta-catenin signaling pathway-related genes and crosstalk pathways in the treatment of As2O3 in renal cancer. Ren Fail. 2018 Nov;40(1):331-339.
• [228] Effects of folate deficiency on gene expression in the apoptosis and cancer pathways in colon cancer cells. Carcinogenesis. 2006 May;27(5):916-24. doi: 10.1093/carcin/bgi312. Epub 2005 Dec 16.
• [229] Treatment with anticancer agents induces dysregulation of specific Wnt signaling pathways in human ovarian luteinized granulosa cells in vitro. Toxicol Sci. 2013 Nov;136(1):183-92. doi: 10.1093/toxsci/kft175. Epub 2013 Aug 16.
• [230] Progesterone increases csk homologous kinase in HMC-1560 human mast cells and reduces cell proliferation. J Cell Biochem. 2007 Dec 1;102(5):1271-80. doi: 10.1002/jcb.21357.
• [231] Cannabidiol upregulates melanogenesis through CB1 dependent pathway by activating p38 MAPK and p42/44 MAPK. Chem Biol Interact. 2017 Aug 1;273:107-114. doi: 10.1016/j.cbi.2017.06.005. Epub 2017 Jun 7.
• [232] Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
• [233] Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2. Int J Cancer. 2006 Mar 15;118(6):1370-80. doi: 10.1002/ijc.21537.
• [234] Estrogen and pure antiestrogen fulvestrant (ICI 182 780) augment cell-matrigel adhesion of MCF-7 breast cancer cells through a novel G protein coupled estrogen receptor (GPR30)-to-calpain signaling axis. Toxicol Appl Pharmacol. 2014 Mar 1;275(2):176-81. doi: 10.1016/j.taap.2014.01.005. Epub 2014 Jan 17.
• [235] Inhibition of activator protein 1 by barbiturates is mediated by differential effects on mitogen-activated protein kinases and the small G proteins ras and rac-1. J Pharmacol Exp Ther. 2004 Dec;311(3):1232-40. doi: 10.1124/jpet.104.071332. Epub 2004 Jul 19.
• [236] Growth of hormone-dependent MCF-7 breast cancer cells is promoted by constitutive caveolin-1 whose expression is lost in an EGF-R-mediated manner during development of tamoxifen resistance. Breast Cancer Res Treat. 2010 Feb;119(3):575-91. doi: 10.1007/s10549-009-0355-8. Epub 2009 Mar 15.
• [237] Effect of histamine H1 receptor antagonists on TARC/CCL17 and MDC/CCL22 production from CD14+ cells induced by antigenic stimulation in vitro. Int Arch Allergy Immunol. 2011;155(1):38-51. doi: 10.1159/000318720. Epub 2010 Nov 25.
• [238] SIRT3 Mediates the Antioxidant Effect of Hydrogen Sulfide in Endothelial Cells. Antioxid Redox Signal. 2016 Feb 20;24(6):329-43. doi: 10.1089/ars.2015.6331. Epub 2015 Nov 10.
• [239] Downregulation of mitogen-activated protein kinases (MAPKs) in chronic ethanol-induced fatty liver. Toxicol Mech Methods. 2020 Jul;30(6):407-416. doi: 10.1080/15376516.2020.1747126. Epub 2020 Apr 1.
• [240] A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16657-62. doi: 10.1073/pnas.0707936104. Epub 2007 Oct 9.
• [241] The stent-eluting drugs sirolimus and paclitaxel suppress healing of the endothelium by induction of autophagy. Am J Pathol. 2009 Nov;175(5):2226-34.
• [242] Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids. J Biol Chem. 2005 Sep 9;280(36):31498-507. doi: 10.1074/jbc.M505537200. Epub 2005 Jul 13.
• [243] Comparative gene expression analysis of a chronic myelogenous leukemia cell line resistant to cyclophosphamide using oligonucleotide arrays and response to tyrosine kinase inhibitors. Leuk Res. 2007 Nov;31(11):1511-20.
• [244] Variants of peroxiredoxins expression in response to hydroperoxide stress. Free Radic Biol Med. 2001 Mar 15;30(6):625-35. doi: 10.1016/s0891-5849(00)00503-7.
• [245] Protein profile in neuroblastoma cells incubated with S- and R-enantiomers of ibuprofen by iTRAQ-coupled 2-D LC-MS/MS analysis: possible action of induced proteins on Alzheimer's disease. Proteomics. 2008 Apr;8(8):1595-607. doi: 10.1002/pmic.200700556.
• [246] A comparative proteomic analysis for capsaicin-induced apoptosis between human hepatocarcinoma (HepG2) and human neuroblastoma (SK-N-SH) cells. Proteomics. 2008 Nov;8(22):4748-67. doi: 10.1002/pmic.200800094.
• [247] Ornithine decarboxylase antizyme upregulates DNA-dependent protein kinase and enhances the nonhomologous end-joining repair of DNA double-strand breaks in human oral cancer cells. Biochemistry. 2007 Aug 7;46(31):8920-32. doi: 10.1021/bi7000328. Epub 2007 Jul 14.
• [248] The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
• [249] Proteomics analysis of the proliferative effect of low-dose ouabain on human endothelial cells. Biol Pharm Bull. 2007 Feb;30(2):247-53. doi: 10.1248/bpb.30.247.
• [250] Linalool is a PPARalpha ligand that reduces plasma TG levels and rewires the hepatic transcriptome and plasma metabolome. J Lipid Res. 2014 Jun;55(6):1098-110.
• [251] Growth inhibition of ovarian tumor-initiating cells by niclosamide. Mol Cancer Ther. 2012 Aug;11(8):1703-12.
• [252] Arsenic modulates posttranslational S-nitrosylation and translational proteome in keratinocytes. ScientificWorldJournal. 2014;2014:360153.
• [253] In vitro antioxidant and antigenotoxic potentials of 3,5-O-di-galloylquinic acid extracted from Myrtus communis leaves and modulation of cell gene expression by H2O2. J Appl Toxicol. 2012 May;32(5):333-41.
• [254] Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
• [255] Gene alterations of ovarian cancer cells expressing estrogen receptors by estrogen and bisphenol a using microarray analysis. Lab Anim Res. 2011 Jun;27(2):99-107. doi: 10.5625/lar.2011.27.2.99. Epub 2011 Jun 22.
• [256] Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
• [257] PCI-24781 induces caspase and reactive oxygen species-dependent apoptosis through NF-kappaB mechanisms and is synergistic with bortezomib in lymphoma cells. Clin Cancer Res. 2009 May 15;15(10):3354-65. doi: 10.1158/1078-0432.CCR-08-2365. Epub 2009 May 5.
• [258] Cannabinoids synergize with carfilzomib, reducing multiple myeloma cells viability and migration. Oncotarget. 2016 Nov 22;7(47):77543-77557. doi: 10.18632/oncotarget.12721.
• [259] [Inhibitory effect of arsenic trioxide on invasion in human hepatocellular carcinoma SMMC-7721 cells and its mechanism]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2012 Dec;28(12):1254-7.
• [260] SU5416, a small molecule tyrosine kinase receptor inhibitor, has biologic activity in patients with refractory acute myeloid leukemia or myelodysplastic syndromes. Blood. 2003 Aug 1;102(3):795-801. doi: 10.1182/blood-2002-10-3023. Epub 2003 Mar 20.
• [261] Cannabinoids inhibit the vascular endothelial growth factor pathway in gliomas. Cancer Res. 2004 Aug 15;64(16):5617-23. doi: 10.1158/0008-5472.CAN-03-3927.
• [262] Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
• [263] Inhibition of endothelial cell proliferation and angiogenesis by orlistat, a fatty acid synthase inhibitor. FASEB J. 2006 Oct;20(12):2027-35. doi: 10.1096/fj.05-5404com.
• [264] Quercetin in elimination of tumor initiating stem-like and mesenchymal transformation property in head and neck cancer. Head Neck. 2013 Mar;35(3):413-9. doi: 10.1002/hed.22982. Epub 2012 Mar 16.
• [265] Effects of all-trans and 9-cis retinoic acid on differentiating human neural stem cells in vitro. Toxicology. 2023 Mar 15;487:153461. doi: 10.1016/j.tox.2023.153461. Epub 2023 Feb 16.
• [266] Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Toxicol Appl Pharmacol. 2012 Jun 1;261(2):204-16.
• [267] Protein expression profiling identifies molecular targets of quercetin as a major dietary flavonoid in human colon cancer cells. Proteomics. 2004 Jul;4(7):2160-74.
• [268] Cannabidiol Modulates the Expression of Alzheimer's Disease-Related Genes in Mesenchymal Stem Cells. Int J Mol Sci. 2016 Dec 23;18(1):26. doi: 10.3390/ijms18010026.
• [269] Regulation of secretases by all-trans-retinoic acid. FEBS J. 2009 May;276(9):2645-55. doi: 10.1111/j.1742-4658.2009.06992.x. Epub 2009 Mar 25.
• [270] Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain. Toxicol Lett. 2015 Apr 16;234(2):139-50.
• [271] Long-term estrogen exposure promotes carcinogen bioactivation, induces persistent changes in gene expression, and enhances the tumorigenicity of MCF-7 human breast cancer cells. Toxicol Appl Pharmacol. 2009 Nov 1;240(3):355-66.
• [272] Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
• [273] The DNA methyltransferase inhibitors azacitidine, decitabine and zebularine exert differential effects on cancer gene expression in acute myeloid leukemia cells. Leukemia. 2009 Jun;23(6):1019-28.
• [274] Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions. Toxicol In Vitro. 2009 Apr;23(3):466-75. doi: 10.1016/j.tiv.2008.12.018. Epub 2008 Dec 30.
• [275] Expression and DNA methylation changes in human breast epithelial cells after bisphenol A exposure. Int J Oncol. 2012 Jul;41(1):369-77.
• [276] Gene expression profile induced by BCNU in human glioma cell lines with differential MGMT expression. J Neurooncol. 2005 Jul;73(3):189-98.
• [277] Rigosertib as a selective anti-tumor agent can ameliorate multiple dysregulated signaling transduction pathways in high-grade myelodysplastic syndrome. Sci Rep. 2014 Dec 4;4:7310. doi: 10.1038/srep07310.
• [278] AP24534, a pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance. Cancer Cell. 2009 Nov 6;16(5):401-12. doi: 10.1016/j.ccr.2009.09.028.
• [279] Role of all-trans retinoic acid in neurite outgrowth and axonal elongation. J Neurobiol. 2006 Jun;66(7):739-56. doi: 10.1002/neu.20241.
• [280] Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
• [281] Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy. Med Oncol. 2011 Dec;28(4):1395-404. doi: 10.1007/s12032-010-9603-3. Epub 2010 Jul 2.
• [282] Homoharringtonine suppresses LoVo cell growth by inhibiting EphB4 and the PI3K/AKT and MAPK/EKR1/2 signaling pathways. Food Chem Toxicol. 2020 Feb;136:110960. doi: 10.1016/j.fct.2019.110960. Epub 2019 Nov 11.
• [283] Gene expression in human hippocampus from cocaine abusers identifies genes which regulate extracellular matrix remodeling. PLoS One. 2007 Nov 14;2(11):e1187. doi: 10.1371/journal.pone.0001187.
• [284] Moving toward integrating gene expression profiling into high-throughput testing: a gene expression biomarker accurately predicts estrogen receptor alpha modulation in a microarray compendium. Toxicol Sci. 2016 May;151(1):88-103.
• [285] The platelet P2Y12 receptor contributes to granule secretion through Ephrin A4 receptor. Platelets. 2012;23(8):617-25. doi: 10.3109/09537104.2011.645924. Epub 2012 Jan 24.
• [286] Comparison of quantitation methods in proteomics to define relevant toxicological information on AhR activation of HepG2 cells by BaP. Toxicology. 2021 Jan 30;448:152652. doi: 10.1016/j.tox.2020.152652. Epub 2020 Dec 2.
• [287] The retinoid anticancer signal: mechanisms of target gene regulation. Br J Cancer. 2005 Aug 8;93(3):310-8. doi: 10.1038/sj.bjc.6602700.
• [288] Transcriptional and epigenetic regulation of the integrin collagen receptor locus ITGA1-PELO-ITGA2. Biochim Biophys Acta. 2007 Sep-Oct;1769(9-10):546-58. doi: 10.1016/j.bbaexp.2007.06.004. Epub 2007 Jul 6.
• [289] Proteomic analysis of hepatic effects of phenobarbital in mice with humanized liver. Arch Toxicol. 2022 Oct;96(10):2739-2754. doi: 10.1007/s00204-022-03338-7. Epub 2022 Jul 26.
• [290] Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
• [291] DNA array analysis of the effects of aspirin on colon cancer cells: involvement of Rac1. Carcinogenesis. 2004 Jul;25(7):1293-8.
• [292] Statins induce apoptosis in ovarian cancer cells through activation of JNK and enhancement of Bim expression. Cancer Chemother Pharmacol. 2009 May;63(6):997-1005. doi: 10.1007/s00280-008-0830-7. Epub 2008 Sep 3.
• [293] Niclosamide acts as a new inhibitor of vasculogenic mimicry in oral cancer through upregulation of miR-124 and downregulation of STAT3. Oncol Rep. 2018 Feb;39(2):827-833. doi: 10.3892/or.2017.6146. Epub 2017 Dec 11.
• [294] Effects of metformin and pioglitazone combination on apoptosis and AMPK/mTOR signaling pathway in human anaplastic thyroid cancer cells. J Biochem Mol Toxicol. 2020 Oct;34(10):e22547. doi: 10.1002/jbt.22547. Epub 2020 Jun 26.
• [295] Time series analysis of oxidative stress response patterns in HepG2: a toxicogenomics approach. Toxicology. 2013 Apr 5;306:24-34.
• [296] Exposure to Insecticides Modifies Gene Expression and DNA Methylation in Hematopoietic Tissues In Vitro. Int J Mol Sci. 2023 Mar 26;24(7):6259. doi: 10.3390/ijms24076259.
• [297] MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia. Cell Biol Toxicol. 2023 Feb;39(1):201-216. doi: 10.1007/s10565-021-09639-4. Epub 2021 Sep 28.
• [298] Inhibition of beta-globin gene expression by 3'-azido-3'-deoxythymidine in human erythroid progenitor cells. Antiviral Res. 1999 Dec 31;44(3):167-77. doi: 10.1016/s0166-3542(99)00065-0.
• [299] Changes in DNA methylation of erythroid-specific genes in K562 cells exposed to phenol and hydroquinone. Toxicology. 2013 Oct 4;312:108-14. doi: 10.1016/j.tox.2013.08.007. Epub 2013 Aug 20.
• [300] Voxelotor for the treatment of sickle cell disease. Expert Rev Hematol. 2021 Mar;14(3):253-262. doi: 10.1080/17474086.2021.1893688. Epub 2021 Mar 4.
• [301] Label-Free Bottom-Up Proteomic Workflow for Simultaneously Assessing the Target Specificity of Covalent Drug Candidates and Their Off-Target Reactivity to Selected Proteins. Chem Res Toxicol. 2016 Jan 19;29(1):109-16. doi: 10.1021/acs.chemrestox.5b00460. Epub 2015 Dec 29.
• [302] Identification of flucloxacillin-modified hepatocellular proteins: implications in flucloxacillin-induced liver injury. Toxicol Sci. 2023 Mar 20;192(1):106-116. doi: 10.1093/toxsci/kfad015.
• [303] Gene expression responses reflecting 5-FU-induced toxicity: Comparison between patient colon tissue and 3D human colon organoids. Toxicol Lett. 2022 Dec 1;371:17-24. doi: 10.1016/j.toxlet.2022.09.013. Epub 2022 Sep 29.
• [304] Incorporation of 5-fluorouracil into U2 snRNA blocks pseudouridylation and pre-mRNA splicing in vivo. Nucleic Acids Res. 2007;35(2):550-8. doi: 10.1093/nar/gkl1084. Epub 2006 Dec 14.
• [305] Antiviral effect of Bosentan and Valsartan during coxsackievirus B3 infection of human endothelial cells. J Gen Virol. 2010 Aug;91(Pt 8):1959-1970. doi: 10.1099/vir.0.020065-0. Epub 2010 Apr 14.
• [306] Moderation of the platelet releasate response by aspirin. Blood. 2007 Jun 1;109(11):4786-92. doi: 10.1182/blood-2006-07-038539. Epub 2007 Feb 15.
• [307] Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. J Biol Chem. 2011 Feb 25;286(8):6602-13.
• [308] Effects of 1 alpha,25-dihydroxy-vitamin D3 and calcipotriol on organotypic cultures of outer root sheath cells: a potential model to evaluate antipsoriatic drugs. Arch Dermatol Res. 1993;285(7):402-9. doi: 10.1007/BF00372133.
• [309] Coordinate up-regulation of TMEM97 and cholesterol biosynthesis genes in normal ovarian surface epithelial cells treated with progesterone: implications for pathogenesis of ovarian cancer. BMC Cancer. 2007 Dec 11;7:223.
• [310] Cannabidiol induces osteoblast differentiation via angiopoietin1 and p38 MAPK. Environ Toxicol. 2020 Dec;35(12):1318-1325. doi: 10.1002/tox.22996. Epub 2020 Jul 13.
• [311] Ethanol impairs intestinal barrier function in humans through mitogen activated protein kinase signaling: a combined in vivo and in vitro approach. PLoS One. 2014 Sep 16;9(9):e107421. doi: 10.1371/journal.pone.0107421. eCollection 2014.
• [312] Hydrocortisone enhances the barrier properties of HBMEC/ci, a brain microvascular endothelial cell line, through mesenchymal-to-endothelial transition-like effects. Fluids Barriers CNS. 2015 Mar 5;12:7. doi: 10.1186/s12987-015-0003-0. eCollection 2015.
• [313] Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
• [314] Mutant p53 reactivation by PRIMA-1MET induces multiple signaling pathways converging on apoptosis. Oncogene. 2010 Mar 4;29(9):1329-38. doi: 10.1038/onc.2009.425. Epub 2009 Nov 30.
• [315] Comparative proteomics reveals concordant and discordant biochemical effects of caffeine versus epigallocatechin-3-gallate in human endothelial cells. Toxicol Appl Pharmacol. 2019 Sep 1;378:114621. doi: 10.1016/j.taap.2019.114621. Epub 2019 Jun 10.
• [316] Expression profiling in squamous carcinoma cells reveals pleiotropic effects of vitamin D3 analog EB1089 signaling on cell proliferation, differentiation, and immune system regulation. Mol Endocrinol. 2002 Jun;16(6):1243-56.
• [317] Cannabis-induced cytotoxicity in leukemic cell lines: the role of the cannabinoid receptors and the MAPK pathway. Blood. 2005 Feb 1;105(3):1214-21. doi: 10.1182/blood-2004-03-1182. Epub 2004 Sep 28.
• [318] Delta9-tetrahydrocannabinol inhibits cytotrophoblast cell proliferation and modulates gene transcription. Mol Hum Reprod. 2006 May;12(5):321-33. doi: 10.1093/molehr/gal036. Epub 2006 Apr 5.
• [319] Exposure-based assessment of chemical teratogenicity using morphogenetic aggregates of human embryonic stem cells. Reprod Toxicol. 2020 Jan;91:74-91. doi: 10.1016/j.reprotox.2019.10.004. Epub 2019 Nov 8.
• [320] Neuronal and cardiac toxicity of pharmacological compounds identified through transcriptomic analysis of human pluripotent stem cell-derived embryoid bodies. Toxicol Appl Pharmacol. 2021 Dec 15;433:115792. doi: 10.1016/j.taap.2021.115792. Epub 2021 Nov 3.
• [321] Gene expression signatures after ethanol exposure in differentiating embryoid bodies. Toxicol In Vitro. 2018 Feb;46:66-76.
• [322] Constructs of human neuropathy target esterase catalytic domain containing mutations related to motor neuron disease have altered enzymatic properties. Toxicol Lett. 2010 Jul 1;196(2):67-73. doi: 10.1016/j.toxlet.2010.03.1120. Epub 2010 Apr 9.
• [323] Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
• [324] Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. Arch Toxicol. 2018 Apr;92(4):1453-1469.
• [325] Endoplasmic reticulum stress contributes to arsenic trioxide-induced intrinsic apoptosis in human umbilical and bone marrow mesenchymal stem cells. Environ Toxicol. 2016 Mar;31(3):314-28.
• [326] Mechanisms of indomethacin-induced alterations in the choline phospholipid metabolism of breast cancer cells. Neoplasia. 2006 Sep;8(9):758-71.
• [327] Effect of chronic exposure to inorganic arsenic on intestinal cells. J Appl Toxicol. 2019 Jun;39(6):899-907. doi: 10.1002/jat.3778. Epub 2019 Feb 12.
• [328] Inflammatory mediators of esophagitis alter p27 Kip1 expression in esophageal epithelial cells. J Pediatr Gastroenterol Nutr. 2010 Nov;51(5):556-62. doi: 10.1097/MPG.0b013e3181ecd65d.
• [329] Regulation of Cdx2 expression by promoter methylation, and effects of Cdx2 transfection on morphology and gene expression of human esophageal epithelial cells. Carcinogenesis. 2007 Feb;28(2):488-96. doi: 10.1093/carcin/bgl176. Epub 2006 Sep 21.
• [330] Evaluation of developmental toxicity using undifferentiated human embryonic stem cells. J Appl Toxicol. 2015 Feb;35(2):205-18.
• [331] Oxyresveratrol improves tight junction integrity through the PKC and MAPK signaling pathways in Caco-2?cells. Food Chem Toxicol. 2017 Oct;108(Pt A):203-213. doi: 10.1016/j.fct.2017.08.002. Epub 2017 Aug 2.
• [332] Systematic transcriptome-based comparison of cellular adaptive stress response activation networks in hepatic stem cell-derived progeny and primary human hepatocytes. Toxicol In Vitro. 2021 Jun;73:105107. doi: 10.1016/j.tiv.2021.105107. Epub 2021 Feb 3.
• [333] Epigenetic changes in individuals with arsenicosis. Chem Res Toxicol. 2011 Feb 18;24(2):165-7. doi: 10.1021/tx1004419. Epub 2011 Feb 4.
• [334] Proteomic profile of aminoglutethimide-induced apoptosis in HL-60 cells: role of myeloperoxidase and arylamine free radicals. Chem Biol Interact. 2015 Sep 5;239:129-38.
• [335] A high concentration of genistein down-regulates activin A, Smad3 and other TGF-beta pathway genes in human uterine leiomyoma cells. Exp Mol Med. 2012 Apr 30;44(4):281-92.
• [336] Gene expression profile induced by arsenic trioxide in chronic lymphocytic leukemia cells reveals a central role for heme oxygenase-1 in apoptosis and regulation of matrix metalloproteinase-9. Oncotarget. 2016 Dec 13;7(50):83359-83377.
• [337] Folic acid inhibits nasopharyngeal cancer cell proliferation and invasion via activation of FR/ERK1/2/TSLC1 pathway. Biosci Rep. 2017 Dec 5;37(6):BSR20170772. doi: 10.1042/BSR20170772. Print 2017 Dec 22.
• [338] Downregulation of TSLC1 and DAL-1 expression occurs frequently in breast cancer. Breast Cancer Res Treat. 2007 Jul;103(3):283-91. doi: 10.1007/s10549-006-9377-7. Epub 2007 Jan 27.
• [339] MIP-1beta, a novel biomarker for in vitro sensitization test using human monocytic cell line. Toxicol In Vitro. 2006 Aug;20(5):736-42.
• [340] Flavones and flavonols exert cytotoxic effects on a human oesophageal adenocarcinoma cell line (OE33) by causing G2/M arrest and inducing apoptosis. Food Chem Toxicol. 2008 Jun;46(6):2042-53. doi: 10.1016/j.fct.2008.01.049. Epub 2008 Feb 7.
• [341] Induction of TAp63 by histone deacetylase inhibitors. Biochem Biophys Res Commun. 2010 Jan 22;391(4):1748-51. doi: 10.1016/j.bbrc.2009.12.147. Epub 2009 Dec 30.
• [342] Bone marrow osteoblast damage by chemotherapeutic agents. PLoS One. 2012;7(2):e30758. doi: 10.1371/journal.pone.0030758. Epub 2012 Feb 17.
• [343] p63 involvement in poly(ADP-ribose) polymerase 1 signaling of topoisomerase I-dependent DNA damage in carcinoma cells. Biochem Pharmacol. 2013 Apr 1;85(7):999-1006. doi: 10.1016/j.bcp.2013.01.019. Epub 2013 Jan 29.
• [344] Environmental pollutant induced cellular injury is reflected in exosomes from placental explants. Placenta. 2020 Jan 1;89:42-49. doi: 10.1016/j.placenta.2019.10.008. Epub 2019 Oct 17.
• [345] Evaluation of an in vitro model of androgen ablation and identification of the androgen responsive proteome in LNCaP cells. Proteomics. 2007 Jan;7(1):47-63.
• [346] Levonorgestrel enhances spermatogenesis suppression by testosterone with greater alteration in testicular gene expression in men. Biol Reprod. 2009 Mar;80(3):484-92.
• [347] METTL14 promotes doxorubicin-induced cardiomyocyte ferroptosis by regulating the KCNQ1OT1-miR-7-5p-TFRC axis. Cell Biol Toxicol. 2023 Jun;39(3):1015-1035. doi: 10.1007/s10565-021-09660-7. Epub 2021 Oct 14.
• [348] Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
• [349] A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies. PLoS Med. 2006 Dec;3(12):e486. doi: 10.1371/journal.pmed.0030486.
• [350] Dose- and time-dependent transcriptional response of Ishikawa cells exposed to genistein. Toxicol Sci. 2016 May;151(1):71-87.
• [351] PARP?1 may be involved in hydroquinone?induced apoptosis by poly ADP?ribosylation of ZO?2. Mol Med Rep. 2017 Dec;16(6):8076-8084. doi: 10.3892/mmr.2017.7643. Epub 2017 Sep 27.
• [352] Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92. doi: 10.1016/j.bbrc.2011.08.027. Epub 2011 Aug 16.
• [353] The antiproliferative effects of progestins in T47D breast cancer cells are tempered by progestin induction of the ETS transcription factor Elf5. Mol Endocrinol. 2010 Jul;24(7):1380-92. doi: 10.1210/me.2009-0516. Epub 2010 Jun 2.
• [354] Genistein disrupts glucocorticoid receptor signaling in human uterine endometrial Ishikawa cells. Environ Health Perspect. 2015 Jan;123(1):80-7. doi: 10.1289/ehp.1408437. Epub 2014 Aug 19.
• [355] Epidermal growth factor receptor signalling in human breast cancer cells operates parallel to estrogen receptor alpha signalling and results in tamoxifen insensitive proliferation. BMC Cancer. 2014 Apr 23;14:283.
• [356] Genistein and bisphenol A exposure cause estrogen receptor 1 to bind thousands of sites in a cell type-specific manner. Genome Res. 2012 Nov;22(11):2153-62.
• [357] Expression Profiling of Human Pluripotent Stem Cell-Derived Cardiomyocytes Exposed to Doxorubicin-Integration and Visualization of Multi-Omics Data. Toxicol Sci. 2018 May 1;163(1):182-195. doi: 10.1093/toxsci/kfy012.
• [358] Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells. Arch Toxicol. 2018 Apr;92(4):1507-1524.
• [359] The thioxotriazole copper(II) complex A0 induces endoplasmic reticulum stress and paraptotic death in human cancer cells. J Biol Chem. 2009 Sep 4;284(36):24306-19.
• [360] Global effects of inorganic arsenic on gene expression profile in human macrophages. Mol Immunol. 2009 Feb;46(4):649-56.
• [361] Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray. Cancer Sci. 2006 Jan;97(1):64-71.
• [362] White-to-brown metabolic conversion of human adipocytes by JAK inhibition. Nat Cell Biol. 2015 Jan;17(1):57-67. doi: 10.1038/ncb3075. Epub 2014 Dec 8.
• [363] Suppression of transforming growth factor beta/smad signaling in keloid-derived fibroblasts by quercetin: implications for the treatment of excessive scars. J Trauma. 2004 Nov;57(5):1032-7. doi: 10.1097/01.ta.0000114087.46566.eb.
• [364] Glucosamine promotes osteogenic differentiation of dental pulp stem cells through modulating the level of the transforming growth factor-beta type I receptor. J Cell Physiol. 2010 Oct;225(1):140-51.
• [365] The differential cancer growth associated with anaesthetics in a cancer xenograft model of mice: mechanisms and implications of postoperative cancer recurrence. Cell Biol Toxicol. 2023 Aug;39(4):1561-1575. doi: 10.1007/s10565-022-09747-9. Epub 2022 Aug 12.
• [366] A high-throughput screen for teratogens using human pluripotent stem cells. Toxicol Sci. 2014 Jan;137(1):76-90. doi: 10.1093/toxsci/kft239. Epub 2013 Oct 23.
• [367] Antiepileptic drugs are endocrine disruptors for the human fetal testis ex vivo. Toxicol Sci. 2023 Sep 28;195(2):169-183. doi: 10.1093/toxsci/kfad076.