Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMMAWY1)

• Drug Name: Adefovir Dipivoxil Drug Info
• Synonyms: Adefovirdipivoxl; Hepsera; Preveon; YouHeDing; Adefovir depivoxil; Adefovir pivoxil; GS 0840; GS 840;Piv2PMEA; Adefovir dipivoxil (USAN); Adefovir pivoxil (JAN); Bis(pom)PMEA; Bis-POM PMEA; GS-0840; GS-840; Hepsera (TM); Hepsera (TN); Preveon (TN); Bis(POM)-PMEA; Bis-POM PMEA, Adefovir Dipivoxil; Bis-POM PMEA, Preveon, Hepsera, Adefovir Dipivoxil; Bis(pivaloyloxymethyl)-9-(2-phosphonylmethoxyethyl)adenine; [2-(6-aminopurin-9-yl)ethoxymethyl-(2,2-dimethylpropanoyloxymethoxy)phosphoryl]oxymethyl 2,2-dimethylpropanoate; Propanoic acid,2,2-dimethyl-(((2-(6-amino-9H-purin-9-yl)ehtoxy)mehtyl)phosphinyldiene)bis(oxymehtylene)ester; Propanoic acid, 2,2-dimethyl-, (((2-(6-amino-9H-purin-9-yl)ethoxy)methyl)phosphinylidene)bis(oxymethylene) ester; (((2-(6-Amino-9H-purin-9-yl)ethoxy)methyl)phosphinylidene)bis(oxymethylene) 2,2-dimethylpropanoate; ((2-(6-Amino-9H-purin-9-yl)ethoxy)methyl)phosphonic acid, diester with hydroxymethyl pivalate; 9-(2-((-Bis((pivaloyloxy)methoxy)phosphinyl)methoxy)ethyl)adenine; 9-(2-((Bis((pivaloyloxy)methoxy)phosphinyl)methoxy)ethyl)adenine; ADV

Indication

Disease Entry	ICD 11	Status	REF
Hepatitis B virus infection	1E51.0	Approved	[1]

• Therapeutic Class: Antiviral Agents
• Cross-matching ID:
  PubChem CID: 60871
  ChEBI ID: CHEBI:31175
  CAS Number: CAS 142340-99-6
  TTD Drug ID: DMMAWY1
  VARIDT Drug ID: DR00444
  INTEDE Drug ID: DR1771
  ACDINA Drug ID: D00014

Molecule-Related Drug Atlas

Drug(s) Targeting Human immunodeficiency virus Reverse transcriptase (HIV RT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[5]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[6]
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[7]
Tenofovir	DM1IS6U	Chronic hepatitis B virus infection		Approved	[5]
Lamivudine	DMI347A	Chronic HBV infection	1E51.0Z	Approved	[2]
Abacavir	DMMN36E	Human immunodeficiency virus infection	1C62	Approved	[8]
Delavirdine	DM3NF5G	Human immunodeficiency virus infection	1C62	Approved	[2]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[2]
Rilpivirine	DMJ0QOW	Human immunodeficiency virus infection	1C62	Approved	[9]
Etravirine	DMGV8QU	Human immunodeficiency virus-1 infection	1C62	Approved	[10]

Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[11]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[12]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[13]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[14]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[15]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[15]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[16]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[17]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[18]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[19]

Drug(s) Affected By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[12]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[20]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[15]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[14]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[21]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[22]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[15]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[23]
Fluconazole	DMOWZ6B	Cryptococcal meningitis		Approved	[14]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[15]

Drug(s) Affected By Neutrophil gelatinase-associated lipocalin (LCN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[25]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[25]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[26]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[27]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[28]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[31]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[32]

Drug(s) Affected By Interleukin-19 (IL19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[31]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[31]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[31]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[31]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[34]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[35]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[36]

Drug(s) Affected By PDZ and LIM domain protein 1 (PDLIM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[4]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[4]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[39]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[40]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[41]

Drug(s) Affected By Pirin (PIR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[42]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[25]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[44]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[45]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[46]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[4]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[47]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[48]

Drug(s) Affected By TRAF-type zinc finger domain-containing protein 1 (TRAFD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[4]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[4]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[39]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[40]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[51]
Bortezomib	DMNO38U	Leukemia		Approved	[52]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[4]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[53]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[54]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[55]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[56]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[57]
Selenium	DM25CGV	N. A.	N. A.	Approved	[58]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[53]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[59]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[59]

Drug(s) Affected By Long-chain fatty acid transport protein 2 (SLC27A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[61]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[64]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[44]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[67]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]

Drug(s) Affected By Protein phosphatase 1D (PPM1D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[68]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[70]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[53]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[71]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[72]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[73]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[4]

Drug(s) Affected By Cochlin (COCH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[44]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[4]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[47]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[4]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[75]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[76]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]

Drug(s) Affected By Protein regulator of cytokinesis 1 (PRC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[78]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[79]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[4]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]

Drug(s) Affected By TP53-regulated inhibitor of apoptosis 1 (TRIAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[53]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[46]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[47]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[4]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[4]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[83]

Drug(s) Affected By 5'-AMP-activated protein kinase subunit beta-2 (PRKAB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[42]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[4]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[4]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[47]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]

Drug(s) Affected By PR domain zinc finger protein 1 (PRDM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[27]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[85]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[4]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[4]
Ibrutinib	DMHZCPO	Mantle cell lymphoma	2A85.5	Approved	[86]

Drug(s) Affected By Breast cancer anti-estrogen resistance protein 3 (BCAR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[88]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[4]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[40]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[75]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[42]

Drug(s) Affected By Solute carrier organic anion transporter family member 2B1 (SLCO2B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[42]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[64]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[90]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[4]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[28]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[91]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[92]

Drug(s) Affected By Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 (GCNT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[42]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[93]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[95]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[4]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[96]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]

Drug(s) Affected By G1/S-specific cyclin-E2 (CCNE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[97]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[53]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[99]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[101]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[72]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[4]

Drug(s) Affected By Collagen alpha-1(IV) chain (COL4A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[103]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[39]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[104]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[40]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[105]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[106]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[62]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[107]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[108]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[109]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[110]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[111]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[112]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[113]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[114]

Drug(s) Affected By Asparagine synthetase (ASNS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[115]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[116]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[68]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[116]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[117]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[118]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[119]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[116]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[120]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[115]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[121]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[122]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[123]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[124]
Selenium	DM25CGV	N. A.	N. A.	Approved	[125]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[126]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[127]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[128]

Drug(s) Affected By Heat shock 70 kDa protein 1A (HSPA1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[129]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[115]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[130]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[131]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[132]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[62]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[133]

Drug(s) Affected By Retinoic acid receptor alpha (RARA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[102]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[78]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[134]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[4]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[4]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[4]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[135]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[136]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[137]

Drug(s) Affected By Prolyl 4-hydroxylase subunit alpha-1 (P4HA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[138]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[139]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[4]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[4]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[140]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[4]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[141]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[142]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[143]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[144]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[145]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[146]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[147]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[149]

Drug(s) Affected By Histone H1.2 (H1-2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[44]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[4]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[140]

Drug(s) Affected By Aspartate aminotransferase, cytoplasmic (GOT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[152]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[27]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[4]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[39]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[153]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[4]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[115]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[117]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[154]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[155]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[156]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[158]

Drug(s) Affected By Keratin, type I cytoskeletal 15 (KRT15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[42]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[155]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[25]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[25]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[28]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[47]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[4]

Drug(s) Affected By Ephrin-A1 (EFNA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[159]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[42]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[160]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[46]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[28]

Drug(s) Affected By Diacylglycerol kinase alpha (DGKA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[161]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[73]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[4]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[162]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[4]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[163]

Drug(s) Affected By Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[115]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[130]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[164]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[117]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[166]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[167]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[168]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[169]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[170]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[102]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[70]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[171]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[172]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[173]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[174]
Fructose	DM43AN2	Vomiting	MD90	Approved	[175]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[102]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[176]

Drug(s) Affected By Adenylate kinase 4, mitochondrial (AK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[177]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[4]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[47]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[176]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[4]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[39]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[178]

Drug(s) Affected By Tyrosine-protein kinase receptor UFO (AXL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[167]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[155]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[167]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[179]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[4]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[4]

Drug(s) Affected By 14-3-3 protein sigma (SFN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[97]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[164]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[180]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[167]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[181]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[182]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[167]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[183]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[184]

Drug(s) Affected By Cystathionine gamma-lyase (CTH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[115]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[185]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[44]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[158]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[186]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[27]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[115]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[4]

Drug(s) Affected By Aryl hydrocarbon receptor (AHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[78]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[187]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[188]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[189]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[190]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[191]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[192]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[193]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[194]

Drug(s) Affected By Serpin B5 (SERPINB5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[128]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[195]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[28]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[196]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[197]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[89]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[69]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[198]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[199]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[200]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[201]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[202]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[203]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[174]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[204]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[205]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[101]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[206]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[207]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[208]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[209]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[210]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[211]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[212]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[53]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 9 (TNFSF9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[53]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[62]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[167]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[213]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[46]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]

Drug(s) Affected By Mitogen-activated protein kinase kinase kinase 8 (MAP3K8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[130]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[42]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[182]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[96]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[47]

Drug(s) Affected By Retinaldehyde dehydrogenase 3 (ALDH1A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[214]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[215]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[46]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[4]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]

Drug(s) Affected By Sodium- and chloride-dependent glycine transporter 1 (SLC6A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[142]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[217]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[4]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[4]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[4]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[4]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[4]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[41]

Drug(s) Affected By Max-interacting protein 1 (MXI1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[100]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[4]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[4]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[140]
2-deoxyglucose	DMIAHVU	Solid tumour/cancer	2A00-2F9Z	Approved	[154]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[218]

Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[219]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[220]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[221]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[219]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[94]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[219]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[222]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[73]

Drug(s) Affected By Dipeptidyl peptidase 1 (CTSC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[4]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[4]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[223]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[4]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[39]

Drug(s) Affected By Delta-1-pyrroline-5-carboxylate synthase (ALDH18A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[46]
Haloperidol	DM96SE0	Delirium		Approved	[224]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[39]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[4]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[225]
Bortezomib	DMNO38U	Leukemia		Approved	[52]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[75]

Drug(s) Affected By Homeobox protein DLX-1 (DLX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[38]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[4]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[4]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[4]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[226]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[227]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[228]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[35]

Drug(s) Affected By Protein BTG2 (BTG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[53]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[229]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[230]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[231]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[232]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[72]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[85]

Drug(s) Affected By Cyclin-dependent kinase 6 (CDK6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[233]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[114]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[234]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[235]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[236]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[237]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]

Drug(s) Affected By E3 ubiquitin-protein ligase Mdm2 (MDM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[55]
Flucytosine	DM13VTW	Cryptococcal meningitis		Approved	[238]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[238]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[239]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[128]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[240]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[107]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[158]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[241]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[242]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[243]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[24]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[244]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[102]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[245]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[209]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[246]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[247]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[212]

Drug(s) Affected By Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[115]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[61]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[70]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[248]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[249]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[250]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[251]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[252]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[158]

Drug(s) Affected By Dihydropyrimidinase-related protein 3 (DPYSL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[253]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[254]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[4]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[39]

Drug(s) Affected By Protein disulfide-isomerase A5 (PDIA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[38]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[4]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[4]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[39]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[4]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[4]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[42]

Drug(s) Affected By Condensin complex subunit 1 (NCAPD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[4]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[255]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[39]

Drug(s) Affected By Plectin (PLEC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[224]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[253]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[256]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[257]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[258]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[4]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]

Drug(s) Affected By Disks large-associated protein 5 (DLGAP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[61]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[259]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[4]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]

Drug(s) Affected By Neuronal regeneration-related protein (NREP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[121]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[138]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[4]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[4]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[140]

Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[260]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[261]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[262]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[263]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[264]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[265]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[266]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[267]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[121]

Drug(s) Affected By Laminin subunit alpha-3 (LAMA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[25]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[25]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[4]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[28]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[4]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[4]

Drug(s) Affected By ALS2 C-terminal-like protein (ALS2CL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[46]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[4]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[4]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[31]

Drug(s) Affected By ATPase family AAA domain-containing protein 2 (ATAD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[268]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[269]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[4]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[270]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[140]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[39]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[104]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[225]

Drug(s) Affected By Ribosomal protein eS27-like (RPS27L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[46]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[73]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[47]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[271]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[4]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[272]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[140]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[39]

Drug(s) Affected By BEN domain-containing protein 5 (BEND5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[44]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[4]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[31]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[4]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[273]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[34]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[38]

Drug(s) Affected By Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[274]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[274]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[46]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[73]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[4]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[271]

Drug(s) Affected By Protein mono-ADP-ribosyltransferase TIPARP (TIPARP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[42]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[72]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[4]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]

Drug(s) Affected By Dynein axonemal intermediate chain 3 (DNAI3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[4]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[76]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[275]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[276]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[277]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[278]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[140]

Drug(s) Affected By Extracellular sulfatase Sulf-2 (SULF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[66]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[4]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[4]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[47]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]

Drug(s) Affected By Stromal membrane-associated protein 1 (SMAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[4]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[162]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[39]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[279]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[280]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[91]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[227]

Drug(s) Affected By Polypeptide N-acetylgalactosaminyltransferase 16 (GALNT16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[31]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[40]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[4]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[280]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[281]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[281]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[282]

Drug(s) Affected By F-box only protein 22 (FBXO22)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[4]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[4]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[4]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[39]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[283]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[284]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[4]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[77]

Drug(s) Affected By Pantothenate kinase 1 (PANK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[4]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[4]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[39]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[157]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[31]

Drug(s) Affected By SH3 domain and tetratricopeptide repeat-containing protein 1 (SH3TC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[27]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[4]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[96]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[4]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[4]

Drug(s) Affected By Histone acetyltransferase KAT6B (KAT6B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[45]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[46]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[4]
Bortezomib	DMNO38U	Leukemia		Approved	[52]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[285]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[4]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[286]

Drug(s) Affected By DNA damage-binding protein 2 (DDB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[42]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[287]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[46]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[4]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]

Drug(s) Affected By Ninjurin-1 (NINJ1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[252]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[87]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[73]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[252]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[140]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[4]

Drug(s) Affected By Tumor protein p53-inducible nuclear protein 1 (TP53INP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[42]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[26]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[72]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[4]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[4]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]

Drug(s) Affected By Carboxymethylenebutenolidase homolog (CMBL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[73]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[4]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[4]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[4]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[39]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[40]

Drug(s) Affected By Aurora kinase B (AURKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[206]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[98]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[288]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[268]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[4]

Drug(s) Affected By ERO1-like protein alpha (ERO1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[289]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[4]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[39]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[31]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[40]

Drug(s) Affected By Bcl-2-modifying factor (BMF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[257]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[154]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[186]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[290]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[47]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[136]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[157]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[291]

Drug(s) Affected By Growth/differentiation factor 15 (GDF15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[115]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[53]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[117]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[292]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[293]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[25]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[25]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[294]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[295]

Drug(s) Affected By Cancer-related nucleoside-triphosphatase (NTPCR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[4]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[47]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[4]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[4]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[40]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[75]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[4]

Drug(s) Affected By G-protein coupled receptor 87 (GPR87)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[216]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[4]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[223]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[4]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[4]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[296]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[297]

Drug(s) Affected By Angiopoietin-related protein 4 (ANGPTL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[214]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[298]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[4]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[4]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[162]

Drug(s) Affected By Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[42]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[80]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[299]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[4]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[271]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[300]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[31]

Drug(s) Affected By p53-induced death domain-containing protein 1 (PIDD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[53]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[301]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[4]

Drug(s) Affected By Fructose-2,6-bisphosphatase TIGAR (TIGAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[42]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[53]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[73]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[4]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[151]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[4]

Drug(s) Affected By Lysine-specific demethylase 3A (KDM3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[61]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[302]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[50]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[158]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[33]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[4]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]

Drug(s) Affected By Pleckstrin homology-like domain family A member 3 (PHLDA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[53]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[46]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[30]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[4]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[140]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[4]

Drug(s) Affected By Phosphoserine aminotransferase (PSAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[115]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[185]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[268]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[303]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[115]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[4]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[47]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[162]

Drug(s) Affected By Sestrin-1 (SESN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[143]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[53]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[66]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[72]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[304]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[82]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[4]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Hepatitis B virus Reverse transcriptase (HBV RT)	TTS5K1M	DPOL_HBVA3	Modulator	[2]
Human immunodeficiency virus Reverse transcriptase (HIV RT)	TT84ETX	POL_HV1B1	Modulator	[2]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
ATP-AMP transphosphorylase 2 (AK2) Main DME	DEY1FJO	KAD2_HUMAN	Substrate	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
(E3-independent) E2 ubiquitin-conjugating enzyme	OTHGS2VA	UBE2O_HUMAN	Gene/Protein Processing	[4]
14-3-3 protein sigma (SFN)	OTLJCZ1U	1433S_HUMAN	Gene/Protein Processing	[4]
5'-AMP-activated protein kinase subunit beta-2 (PRKAB2)	OTLVN68B	AAKB2_HUMAN	Gene/Protein Processing	[4]
Adenylate kinase 4, mitochondrial (AK4)	OTA0T02Q	KAD4_HUMAN	Gene/Protein Processing	[4]
Aldo-keto reductase family 1 member C2 (AKR1C2)	OTQ2XMO3	AK1C2_HUMAN	Gene/Protein Processing	[4]
ALS2 C-terminal-like protein (ALS2CL)	OT8RY7TZ	AL2CL_HUMAN	Gene/Protein Processing	[4]
Angiopoietin-related protein 4 (ANGPTL4)	OTQL5SPX	ANGL4_HUMAN	Gene/Protein Processing	[4]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[4]
Aryl hydrocarbon receptor (AHR)	OTFE4EYE	AHR_HUMAN	Gene/Protein Processing	[4]
Asparagine synthetase (ASNS)	OT8R922G	ASNS_HUMAN	Gene/Protein Processing	[4]

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