Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMZC90M)

• Drug Name: PD98059 Drug Info
• Synonyms: 167869-21-8; PD 98059; 2-(2-amino-3-methoxyphenyl)-4H-chromen-4-one; PD-98059; PD 98,059; 2-(2-amino-3-methoxyphenyl)chromen-4-one; 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one; 2'-AMINO-3'-METHOXYFLAVONE; PD-098059; 4H-1-Benzopyran-4-one, 2-(2-Amino-3-methoxyphenyl)-; UNII-SJE1IO5E3I; SJE1IO5E3I; CHEMBL35482; C16H13NO3; CHEBI:77954; MFCD00671789; 2-(2-Amino-3-methoxy-phenyl)-chromen-4-one; SR-01000076097; PD 098059; 2-(2-Amino-3-methoxyphenyl)-chromen-4-one; NSC 679829; Tocris-1213; PD098059; Lopac-P-215; BiomolKI_000001; 2-(2-amino-3-methoxy-phenyl)chromen-4-one; BiomolKI2_000011; PD 98,059, solid; Lopac0_001028; BMK1-B1; BSPBio_000996; KBioGR_000336; KBioSS_000336; 2-(2'-amino-3'-methoxyphenyl)oxanaphthalen-4-one; cc-461; MLS006010134; SCHEMBL157826; 4H-1-Benzopyran-4-one,2-(2-amino-3-methoxyphenyl)-; GTPL5241; QCR-14; 2''-amino-3''-methoxyflavone; BCBcMAP01_000049; KBio2_000336; KBio2_002904; KBio2_005472; KBio3_000671; KBio3_000672; AOB2598; DTXSID40168416; BCPP000123; Bio1_000475; Bio1_000964; Bio1_001453; Bio2_000338; Bio2_000818; HMS1362B17; HMS1792B17; HMS1990B17; HMS3229M08; HMS3263M17; HMS3267D03; HMS3403B17; HMS3412O09; HMS3649N14; HMS3654I16; HMS3676O09; BCP02423; EX-A2127; ZINC1420826; Tox21_501028; ABP000927; BDBM50108771; NSC679828; s1177; AKOS015995212; BCP9001060; CCG-100605; CS-0169; LP01028; NSC 679828; NSC-679828; SB16629; SDCCGSBI-0051000.P003; IDI1_002093; SMP2_000052; NCGC00015790-01; NCGC00015790-02; NCGC00015790-03; NCGC00015790-04; NCGC00015790-05; NCGC00015790-06; NCGC00015790-07; NCGC00015790-08; NCGC00025045-01; NCGC00025045-02; NCGC00025045-03; NCGC00025045-04; NCGC00025045-05; NCGC00179347-01; NCGC00261713-01; AC-28412; AK-60664; AS-19374; HY-12028; NCI60_028554; SMR001456459; AB0033706; EU-0101028; FT-0716482; P-215; PD-98059/PD98059/; SW218254-2; X7398; EC-000.2425; A25454; P-4313; PD 98059 & Z-100; InSolution PD 98059 - CAS 167869-21-8; J-505513; SR-01000076097-1; SR-01000076097-3; SR-01000076097-6; 2-(2-amino-3-methoxyphenyl)-4-oxo-4H-[1]benzopyran; BRD-K62810658-001-05-6; BRD-K62810658-001-06-4; Q27088281; 2-(2-Amino-3-methoxy-phenyl)-chromen-4-one(PD98059); PD 98059 - CAS 167869-21-8; 4H-1-Benzopyran-4-one, 2-(2-amino-3-methoxyphenyl)- & Z-100

Indication

Disease Entry	ICD 11	Status	REF
Cardiac arrest	MC82	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 4713
  ChEBI ID: CHEBI:77954
  CAS Number: CAS 167869-21-8
  TTD Drug ID: DMZC90M

Molecule-Related Drug Atlas

Drug(s) Targeting ERK activator kinase 1 (MEK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selumetinib	DMC7W6R	Neurofibromatosis type 1	LD2D.10	Phase 3	[12]
Diamidothiazole derivative 1	DM02V5Q	N. A.	N. A.	Patented	[13]
Pyridic ketone derivative 1	DM3GU7K	N. A.	N. A.	Patented	[14]
RDEA-436	DM0ILRU	Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 1	[15]
4,5,6,7-tetrabromo-1H-benzo[d][1,2,3]triazole	DMN9YOB	Discovery agent	N.A.	Investigative	[16]
DEBROMOHYMENIALDISINE	DMDLER8	Discovery agent	N.A.	Investigative	[17]
REVERSINE	DMWDNOK	Discovery agent	N.A.	Investigative	[18]
OROIDIN	DMA2DQT	Discovery agent	N.A.	Investigative	[17]
4,5-Dibromo-1H-pyrrole-2-carboxylic acid amide	DMDM9UV	Discovery agent	N.A.	Investigative	[17]
5-phenylamino-4-cyano-3-hydroxy-isothiazole	DMX6R0H	Discovery agent	N.A.	Investigative	[19]

Drug(s) Targeting ERK activator kinase 2 (MEK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selumetinib	DMC7W6R	Neurofibromatosis type 1	LD2D.10	Phase 3	[12]
Pyridic ketone derivative 1	DM3GU7K	N. A.	N. A.	Patented	[14]
RDEA-436	DM0ILRU	Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 1	[15]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[20]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[21]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[22]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[23]
Selenium	DM25CGV	N. A.	N. A.	Approved	[24]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[25]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[26]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[27]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[29]

Drug(s) Affected By Aryl hydrocarbon receptor (AHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[30]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[31]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[32]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[33]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[34]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[38]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[39]

Drug(s) Affected By Cytochrome P450 11B2, mitochondrial (CYP11B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[40]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[41]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Potassium Chloride	DMMTAJC	Hypokalemia	5C77	Approved	[44]
Dutasteride	DMQ4TJK	Benign prostatic hyperplasia	GA90	Approved	[45]
Mitotane	DMU1GX0	Adrenocortical carcinoma	2D11.Z	Approved	[46]
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[42]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[47]
Irbesartan	DMTP1DC	Diabetic kidney disease	GB61.Z	Approved	[48]

Drug(s) Affected By Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[49]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[41]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[52]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[52]
Pyruvic acid	DM7Q41G	Malnutrition	5B50-5B71	Approved	[53]
Topiramate	DM82Z30	Alcohol dependence	6C40.2	Approved	[54]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[54]
ABIRATERONE	DM8V75C	Prostate cancer	2C82.0	Approved	[55]

Drug(s) Affected By 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (HSD3B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[50]
Topiramate	DM82Z30	Alcohol dependence	6C40.2	Approved	[54]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[54]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[56]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[47]
Metyrapone	DMI7FVQ	Cushing disease	5A70	Approved	[57]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[50]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[58]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[4]
Levetiracetam	DMTGDN8	Epilepsy	8A60-8A68	Approved	[47]

Drug(s) Affected By Glutathione S-transferase P (GSTP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[59]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[60]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[61]
Chlorambucil	DMRKE63	Chronic lymphocytic leukaemia	2A82.0	Approved	[61]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[62]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[63]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Selenium	DM25CGV	N. A.	N. A.	Approved	[24]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[65]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[66]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[67]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[68]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[69]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[70]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[71]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[72]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[73]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[74]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[75]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[76]

Drug(s) Affected By Cytochrome P450 11B1, mitochondrial (CYP11B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[77]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[41]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[78]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[79]
Potassium Chloride	DMMTAJC	Hypokalemia	5C77	Approved	[44]
Mitotane	DMU1GX0	Adrenocortical carcinoma	2D11.Z	Approved	[80]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[81]
Dalcetrapib	DMKNCVM	Acute coronary syndrome	BA41	Phase 3	[82]
Anacetrapib	DMP2BFG	Arteriosclerosis	BD40	Phase 3	[82]

Drug(s) Affected By Tumor protein p73 (TP73)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[83]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[84]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[85]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[89]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[90]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[91]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[85]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[92]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[93]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[94]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[95]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[85]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[96]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[97]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[98]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[99]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[100]

Drug(s) Affected By C-X-C motif chemokine 14 (CXCL14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[103]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[104]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[10]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[106]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[60]
Indomethacin	DMSC4A7	Bursitis		Approved	[107]

Drug(s) Affected By Apoptosis-inducing factor 1, mitochondrial (AIFM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[84]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[108]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[95]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[109]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[113]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[114]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[115]

Drug(s) Affected By Metalloproteinase inhibitor 1 (TIMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pentoxifylline	DMU3DNC	Alcoholic hepatitis	DB94.1	Approved	[81]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[116]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[117]
Selenium	DM25CGV	N. A.	N. A.	Approved	[118]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[117]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[119]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[120]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[122]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[123]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[124]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[125]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[126]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[22]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[126]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[127]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[128]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[129]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[130]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[131]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[22]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[127]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[132]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[133]
Selenium	DM25CGV	N. A.	N. A.	Approved	[134]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[135]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[136]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[137]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[138]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[139]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[140]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[141]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[142]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[23]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[142]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[143]
Selenium	DM25CGV	N. A.	N. A.	Approved	[144]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[145]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[146]

Drug(s) Affected By Osteocalcin (BGLAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[148]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[150]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[151]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[152]
Falecalcitrol	DMBI9ZJ	Hyperparathyroidism	5A51	Approved	[153]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[155]

Drug(s) Affected By Interstitial collagenase (MMP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[157]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[158]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[159]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[160]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[161]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[162]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[163]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[164]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]

Drug(s) Affected By Granulocyte-macrophage colony-stimulating factor (CSF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[166]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[72]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[167]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[168]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[169]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[170]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[171]
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[172]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[173]

Drug(s) Affected By Keratin, type II cytoskeletal 1 (KRT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[174]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[175]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[176]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[177]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[178]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[10]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[176]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[179]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[180]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[181]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[138]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[182]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[183]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[184]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[185]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[186]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[187]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[188]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[189]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[190]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[191]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[192]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[193]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[194]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[140]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[195]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[143]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[196]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[190]

Drug(s) Affected By Intercellular adhesion molecule 1 (ICAM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[197]
Dicloxacillin	DM8EU0Z	Bacterial infection	1A00-1C4Z	Approved	[197]
Ergonovine	DM0VEC1	Postpartum haemorrhage	JA43	Approved	[81]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[116]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[198]
Mizolastine	DM1FDN8	Allergic rhinitis	CA08.0	Approved	[199]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[165]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[200]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[201]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[202]

Drug(s) Affected By Retinoblastoma-associated protein (RB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[203]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[204]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[205]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[206]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[136]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[207]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[208]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[209]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[210]

Drug(s) Affected By Eukaryotic translation initiation factor 4E (EIF4E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[211]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[212]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[213]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[214]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[215]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[178]
Momelotinib	DMF98Q0	Myelofibrosis	2A20.2	Approved	[216]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[215]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[217]

Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[157]
Selenium	DM25CGV	N. A.	N. A.	Approved	[118]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[218]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[219]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[220]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[122]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[123]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[222]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[223]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[224]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[193]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[21]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[140]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[225]
Selenium	DM25CGV	N. A.	N. A.	Approved	[226]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[202]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[227]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[160]

Drug(s) Affected By Intestinal-type alkaline phosphatase (ALPI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[228]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[229]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[229]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[230]
Wortmannin	DM8EVK5	Haematological malignancy	2B33.Y	Terminated	[228]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[231]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[84]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[232]
cycloheximide	DMGDA3C	Discovery agent	N.A.	Investigative	[233]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[234]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[235]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[236]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[237]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[81]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[192]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[238]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[239]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[240]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[241]

Drug(s) Affected By Integrin alpha-M (ITGAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[242]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[243]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[244]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[245]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[246]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[247]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[248]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[249]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[250]

Drug(s) Affected By High affinity immunoglobulin gamma Fc receptor I (FCGR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[252]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[253]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[254]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[121]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[255]
Maleic Acid	DM4L0R7	Discovery agent	N.A.	Investigative	[256]
Rapamycin Immunosuppressant Drug	DM678IB	Discovery agent	N.A.	Investigative	[252]
PHENCYCLIDINE	DMQBEYX	Discovery agent	N.A.	Investigative	[257]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[258]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[259]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[260]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[261]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[262]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[263]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[264]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[102]

Drug(s) Affected By Cystic fibrosis transmembrane conductance regulator (CFTR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivacaftor	DMZC1HS	Cystic fibrosis	CA25	Approved	[265]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[266]
Rhucin	DM3ADGP	Erectile dysfunction	HA01.1	Approved	[267]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[268]
Miglustat	DM5J64S	Niemann-Pick disease type C		Approved	[269]
Glibenclamide	DM8JXPZ	Diabetic complication	5A2Y	Approved	[270]
Milrinone	DM8TUPF	Congestive heart failure	BD10	Approved	[267]
Oxidized glutathione	DM9EQC0	Breast cancer	2C60-2C65	Approved	[271]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[271]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[88]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[272]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[30]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[273]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[195]
Selenium	DM25CGV	N. A.	N. A.	Approved	[118]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[274]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[275]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[276]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[277]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[278]

Drug(s) Affected By 15-hydroxyprostaglandin dehydrogenase (HPGD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[138]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[279]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[280]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[281]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[3]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[281]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[282]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[3]

Drug(s) Affected By Cyclic AMP-responsive element-binding protein 1 (CREB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[283]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[284]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[285]
Selenium	DM25CGV	N. A.	N. A.	Approved	[24]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[286]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[287]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[288]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[288]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[289]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[290]

Drug(s) Affected By Platelet glycoprotein 4 (CD36)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[291]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[292]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[293]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[294]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[295]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[296]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[245]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[297]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[298]

Drug(s) Affected By Early growth response protein 1 (EGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[224]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[299]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[300]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[86]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[72]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[301]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[302]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[303]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[124]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[74]

Drug(s) Affected By Cytoplasmic aconitate hydratase (ACO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[84]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[266]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[111]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[124]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[304]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[178]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[305]
Trabectedin	DMG3Y89	Leiomyosarcoma	2B58	Approved	[306]

Drug(s) Affected By Loricrin (LORICRIN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[307]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[308]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[309]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[308]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[310]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[255]
SB 203580	DMAET6F	N. A.	N. A.	Terminated	[311]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[312]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[313]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[241]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[314]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[315]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[206]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[316]
Selenium	DM25CGV	N. A.	N. A.	Approved	[24]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[135]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[317]

Drug(s) Affected By Myosin regulatory light polypeptide 9 (MYL9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[281]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[281]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[318]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[28]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[282]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[319]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[320]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[321]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[322]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[323]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[324]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[284]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[240]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[325]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[326]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[327]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[328]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[329]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[330]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[331]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[324]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[332]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[333]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[334]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[323]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[81]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[139]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[240]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[325]

Drug(s) Affected By CD70 antigen (CD70)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[335]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Vemurafenib	DM62UG5	Melanoma	2C30	Approved	[336]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[337]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[178]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[90]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[338]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[319]

Drug(s) Affected By DNA replication licensing factor MCM7 (MCM7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Selenium	DM25CGV	N. A.	N. A.	Approved	[24]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[339]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[340]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[341]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[342]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[103]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[281]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[281]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[115]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[343]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[344]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[345]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[221]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[346]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[347]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[348]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[349]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[350]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[351]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[352]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[353]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[354]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[355]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[356]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[357]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[358]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[359]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[125]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[360]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[93]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[206]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[299]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[85]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[361]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[362]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[363]

Drug(s) Affected By Leptin (LEP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[194]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[195]
Ramipril	DM2R68E	Acute heart failure	BD10-BD13	Approved	[364]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[365]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[366]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[194]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[194]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[367]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[368]
Amlodipine	DMBDAZV	Angina pectoris	BA40	Approved	[369]

Drug(s) Affected By Cyclin-dependent kinase 4 inhibitor B (CDKN2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[132]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[361]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[370]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[371]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[281]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[281]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[28]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[204]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[315]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[361]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[372]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[373]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[374]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[375]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[376]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[377]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[378]

Drug(s) Affected By E3 ubiquitin-protein ligase Mdm2 (MDM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[139]
Flucytosine	DM13VTW	Cryptococcal meningitis		Approved	[379]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[379]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[380]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[160]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[381]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[182]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[382]
Amifostine	DM5FL14	Mucositis	CA00	Approved	[383]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[234]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[384]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[192]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[238]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[258]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[385]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[206]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[64]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[386]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[362]

Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[240]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[258]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[387]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[276]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[388]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[345]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[301]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[258]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[389]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[390]

Drug(s) Affected By Runt-related transcription factor 2 (RUNX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[391]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[392]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[393]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[394]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[151]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[124]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[395]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[104]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[396]

Drug(s) Affected By DNA replication licensing factor MCM6 (MCM6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[397]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[340]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[341]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[398]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[399]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[281]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[281]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[115]

Drug(s) Affected By Mediator of RNA polymerase II transcription subunit 1 (MED1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[30]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[231]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[400]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[318]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[296]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[178]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[401]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[402]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[30]

Drug(s) Affected By Myosin light chain kinase, smooth muscle (MYLK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[403]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[101]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[102]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[404]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[281]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[405]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[281]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[282]

Drug(s) Affected By Hypoxia-inducible factor 1-alpha (HIF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[406]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[407]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[408]
Triamterene	DM2HU9I	Congestive heart failure	BD10	Approved	[408]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[409]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[410]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[411]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[345]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[412]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[413]

Drug(s) Affected By Proprotein convertase subtilisin/kexin type 9 (PCSK9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[338]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[282]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[414]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[105]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[415]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[416]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[217]

Drug(s) Affected By Transcription factor Sp7 (SP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[148]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[392]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[417]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[418]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[419]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[418]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[255]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[420]
alpha-ketoglutaric acid	DM5LFYN	Discovery agent	N.A.	Investigative	[421]

Drug(s) Affected By Nuclear pore complex protein Nup88 (NUP88)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[231]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[115]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[282]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[178]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[422]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[321]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[423]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[424]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[425]

Drug(s) Affected By Krueppel-like factor 6 (KLF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[192]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[426]
Selenium	DM25CGV	N. A.	N. A.	Approved	[24]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[363]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[427]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[28]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[341]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[102]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[318]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[115]

Drug(s) Affected By Programmed cell death 1 ligand 1 (CD274)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[31]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[251]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[428]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[96]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[429]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[281]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[104]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[318]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[430]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[43]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
ERK activator kinase 1 (MEK1)	TTIDAPM	MP2K1_HUMAN	Inhibitor	[2]
ERK activator kinase 2 (MEK2)	TTTW2NY	MP2K2_HUMAN	Inhibitor	[2]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
15-hydroxyprostaglandin dehydrogenase (HPGD)	OTYZI6JB	PGDH_HUMAN	Gene/Protein Processing	[3]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (HSD3B2)	OT02MSKN	3BHS2_HUMAN	Gene/Protein Processing	[4]
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[5]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[6]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Post-Translational Modifications	[7]
Apoptosis-inducing factor 1, mitochondrial (AIFM1)	OTKPWB7Q	AIFM1_HUMAN	Protein Interaction/Cellular Processes	[6]
Aryl hydrocarbon receptor (AHR)	OTFE4EYE	AHR_HUMAN	Gene/Protein Processing	[8]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Gene/Protein Processing	[9]
C-X-C motif chemokine 14 (CXCL14)	OTM189TA	CXL14_HUMAN	Gene/Protein Processing	[10]
Cadherin-1 (CDH1)	OTFJMXPM	CADH1_HUMAN	Gene/Protein Processing	[11]

References

• [1] PD98059 protects the brain against mitochondrial-mediated apoptosis and autophagy in a cardiac arrest rat model. Life Sci. 2019 Sep 1;232:116618.
• [2] The MEK1 inhibitor PD98059 sensitizes C8161 melanoma cells to cisplatin-induced apoptosis. Melanoma Res. 2001 Feb;11(1):11-9.
• [3] 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is up-regulated by flurbiprofen and other non-steroidal anti-inflammatory drugs in human colon cancer HT29 cells. Arch Biochem Biophys. 2009 Jul 15;487(2):139-45. doi: 10.1016/j.abb.2009.05.017. Epub 2009 Jun 6.
• [4] Pioglitazone inhibits androgen production in NCI-H295R cells by regulating gene expression of CYP17 and HSD3B2. Mol Pharmacol. 2007 Mar;71(3):787-98.
• [5] Ursonic acid exerts inhibitory effects on matrix metalloproteinases via ERK signaling pathway. Chem Biol Interact. 2020 Jan 5;315:108910. doi: 10.1016/j.cbi.2019.108910. Epub 2019 Nov 29.
• [6] Inhibition of extracellular signal regulated kinase (ERK) leads to apoptosis inducing factor (AIF) mediated apoptosis in epithelial breast cancer cells: the lack of effect of ERK in p53 mediated copper induced apoptosis. J Cell Biochem. 2005 Aug 15;95(6):1120-34. doi: 10.1002/jcb.20484.
• [7] Mechanisms of apoptosis sensitivity and resistance to the BH3 mimetic ABT-737 in acute myeloid leukemia. Cancer Cell. 2006 Nov;10(5):375-88. doi: 10.1016/j.ccr.2006.10.006.
• [8] ERK kinase inhibition stabilizes the aryl hydrocarbon receptor: implications for transcriptional activation and protein degradation. J Biol Chem. 2005 Feb 11;280(6):4350-9.
• [9] Myosin light-chain kinase contributes to the proliferation and migration of breast cancer cells through cross-talk with activated ERK1/2. Cancer Lett. 2008 Nov 8;270(2):312-27. doi: 10.1016/j.canlet.2008.05.028. Epub 2008 Aug 16.
• [10] CXCL14 downregulation in human keratinocytes is a potential biomarker for a novel in vitro skin sensitization test. Toxicol Appl Pharmacol. 2020 Jan 1;386:114828. doi: 10.1016/j.taap.2019.114828. Epub 2019 Nov 14.
• [11] Asbestos exposure induces alveolar epithelial cell plasticity through MAPK/Erk signaling. J Cell Biochem. 2012 Jul;113(7):2234-47. doi: 10.1002/jcb.24094.
• [12] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [13] Cyclin-dependent kinase inhibitors for cancer therapy: a patent review (2009 - 2014).Expert Opin Ther Pat. 2015;25(9):953-70.
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