General Information of Drug (ID: DM27D4J)

Drug Name
PD-0325901 Drug Info
Synonyms
PD 0325901; PD 325901; PD0325901; PD325901; PD-325901; S06-0029; N-[((R)-2,3-dihydroxypropyl)oxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide; N-[(2R)-2,3-dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodo-phenyl)amino]benzamide; N-{[(2R)-2,3-dihydroxypropyl]oxy}-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Phase 2 [1]
Therapeutic Class
Anticancer Agents
Cross-matching ID
PubChem CID
9826528
ChEBI ID
CHEBI:88249
CAS Number
CAS 391210-10-9
TTD Drug ID
DM27D4J

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
Patented Agent(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
ARRY-162 DM1P6FR Melanoma 2C30 Approved [2]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [7]
BAY 86-9766 DMPW5SB Solid tumour/cancer 2A00-2F9Z Phase 3 [8]
Selumetinib DMC7W6R Neurofibromatosis type 1 LD2D.10 Phase 3 [9]
MSC1936369B DMH1DYU Colorectal cancer 2B91.Z Phase 2 [10]
RO-5126766 DM3U9BY Non-small-cell lung cancer 2C25 Phase 2 [11]
E6201 DMOSL9P Psoriasis vulgaris EA90 Phase 2 [12]
WX-554 DMRABOS Solid tumour/cancer 2A00-2F9Z Phase 1/2 [2]
RG7304 DMGFAVQ Solid tumour/cancer 2A00-2F9Z Phase 1 [13]
BI-847325 DMY4B6J Solid tumour/cancer 2A00-2F9Z Phase 1 [14]
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Drug(s) Affected By Cytochrome P450 3A4 (CYP3A4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [15]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [16]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [17]
Voriconazole DMAOL2S Aspergillosis 1F20 Approved [18]
Proguanil DMBL79I Malaria 1F40-1F45 Approved [19]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [19]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [20]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [21]
Capsaicin DMGMF6V Back pain ME84.Z Approved [22]
Axitinib DMGVH6N Renal cell carcinoma 2C90 Approved [23]
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Drug(s) Affected By Cytochrome P450 3A5 (CYP3A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [15]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [16]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [21]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [21]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [24]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [25]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [26]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [27]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [29]
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Drug(s) Affected By Cytochrome P450 3A7 (CYP3A7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [30]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [27]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [25]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [31]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [32]
Phenobarbital DMXZOCG Cluster headache 8A81.0 Approved [33]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [34]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [35]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [36]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [37]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Calcipotriol DM03CP7 Psoriasis EA90 Approved [38]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [39]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [40]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [41]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [42]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [39]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [43]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [44]
Quercetin DM3NC4M Obesity 5B81 Approved [45]
Fluoxetine DM3PD2C Bipolar depression Approved [39]
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Drug(s) Affected By Toll-like receptor 4 (TLR4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [46]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [47]
Quercetin DM3NC4M Obesity 5B81 Approved [48]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [49]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [50]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [51]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [52]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [47]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [53]
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Drug(s) Affected By Neuropilin-1 (NRP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [40]
Methotrexate DM2TEOL Anterior urethra cancer Approved [54]
Quercetin DM3NC4M Obesity 5B81 Approved [55]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [56]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [57]
Panobinostat DM58WKG Chronic graft versus host disease Approved [58]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [59]
Leflunomide DMR8ONJ Arthritis FA20 Approved [60]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [61]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [62]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [64]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [65]
Quercetin DM3NC4M Obesity 5B81 Approved [45]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [49]
Panobinostat DM58WKG Chronic graft versus host disease Approved [66]
Propylthiouracil DM6D7N8 Hyperthyroidism 5A02 Approved [64]
Leflunomide DMR8ONJ Arthritis FA20 Approved [60]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [64]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [68]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [69]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [57]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [59]
Leflunomide DMR8ONJ Arthritis FA20 Approved [60]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [27]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [70]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [71]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [72]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [73]
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Drug(s) Affected By Leupaxin (LPXN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [45]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [74]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [75]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [76]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [71]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [72]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [73]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [77]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [78]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [56]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [49]
Panobinostat DM58WKG Chronic graft versus host disease Approved [58]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [79]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [80]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [53]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [53]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [53]
Ibrutinib DMHZCPO Mantle cell lymphoma 2A85.5 Approved [81]
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Drug(s) Affected By Slit homolog 2 protein (SLIT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [68]
Selenium DM25CGV N. A. N. A. Approved [82]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [57]
Panobinostat DM58WKG Chronic graft versus host disease Approved [58]
Testosterone DM7HUNW Hot flushes GA30 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [27]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [70]
Folic Acid DMEMBJC Colorectal carcinoma Approved [84]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [72]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [85]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [54]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [49]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [86]
Testosterone DM7HUNW Hot flushes GA30 Approved [87]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [87]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [70]
Clozapine DMFC71L Schizophrenia 6A20 Approved [88]
Menthol DMG2KW7 Back pain ME84.Z Approved [89]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [90]
Arsenic DMTL2Y1 N. A. N. A. Approved [91]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [92]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [93]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [94]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [95]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [96]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [94]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [97]
Folic Acid DMEMBJC Colorectal carcinoma Approved [84]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [98]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [99]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [100]
Methotrexate DM2TEOL Anterior urethra cancer Approved [101]
Quercetin DM3NC4M Obesity 5B81 Approved [102]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [56]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [57]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [100]
Panobinostat DM58WKG Chronic graft versus host disease Approved [58]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [103]
Leflunomide DMR8ONJ Arthritis FA20 Approved [60]
Atorvastatin DMF28YC Acute coronary syndrome BA41 Approved [104]
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Drug(s) Affected By Interleukin-1 beta (IL1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [106]
Gefitinib DM15F0X Colon adenocarcinoma Approved [107]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [108]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [109]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [108]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [110]
Selenium DM25CGV N. A. N. A. Approved [111]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [112]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [113]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [114]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [115]
Etretinate DM2CZFA Keratosis ED56 Approved [116]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [117]
Methotrexate DM2TEOL Anterior urethra cancer Approved [54]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [118]
Quercetin DM3NC4M Obesity 5B81 Approved [119]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [120]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [121]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [122]
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Drug(s) Affected By Glycophorin-C (GYPC)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [49]
Panobinostat DM58WKG Chronic graft versus host disease Approved [58]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [61]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [123]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [77]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [78]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [124]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [125]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [126]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [127]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [128]
Selenium DM25CGV N. A. N. A. Approved [111]
Methotrexate DM2TEOL Anterior urethra cancer Approved [101]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [94]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [56]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [30]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [129]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [30]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [130]
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Drug(s) Affected By Interleukin-8 (CXCL8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [131]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [132]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [133]
Pantothenic acid DM091H2 Vitamin deficiency 5B55-5B71 Approved [134]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [135]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [106]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [108]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [109]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [136]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [108]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [137]
Quercetin DM3NC4M Obesity 5B81 Approved [45]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [49]
Panobinostat DM58WKG Chronic graft versus host disease Approved [58]
Estrone DM5T6US Acne vulgaris ED80 Approved [137]
Testosterone DM7HUNW Hot flushes GA30 Approved [138]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [27]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [70]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [76]
Ethanol DMDRQZU Chronic pain MG30 Approved [139]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [140]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [141]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [57]
Panobinostat DM58WKG Chronic graft versus host disease Approved [58]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [142]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [143]
Ethanol DMDRQZU Chronic pain MG30 Approved [144]
Cholecalciferol DMGU74E Adult acute monocytic leukemia Approved [145]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [90]
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Drug(s) Affected By Aminopeptidase N (ANPEP)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Selenium DM25CGV N. A. N. A. Approved [82]
Methotrexate DM2TEOL Anterior urethra cancer Approved [146]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [56]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [74]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [147]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [148]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [27]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [149]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [150]
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Drug(s) Affected By Integrin alpha-2 (ITGA2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [128]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [65]
Quercetin DM3NC4M Obesity 5B81 Approved [45]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [56]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [49]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [151]
Testosterone DM7HUNW Hot flushes GA30 Approved [87]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [87]
Leflunomide DMR8ONJ Arthritis FA20 Approved [60]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [152]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [153]
Etretinate DM2CZFA Keratosis ED56 Approved [154]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [155]
Testosterone DM7HUNW Hot flushes GA30 Approved [87]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [87]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [156]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [150]
Ethanol DMDRQZU Chronic pain MG30 Approved [157]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [158]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [111]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [57]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [159]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [27]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [70]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [76]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [71]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [160]
Bortezomib DMNO38U Leukemia Approved [161]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [162]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [57]
Cyproheptadine DM92AH3 Allergic rhinitis CA08.0 Approved [163]
Clozapine DMFC71L Schizophrenia 6A20 Approved [163]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [73]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [164]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [165]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [126]
SL65.0472 DMU5RKC Cardiovascular disease BA00-BE2Z Discontinued in Phase 2 [166]
SB-269970 DM8WTGA Sleep-wake disorder 7A00-7B2Z Terminated [163]
ICI-169369 DMQ0IOF Anxiety disorder 6B00-6B0Z Terminated [163]
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Drug(s) Affected By Glutaredoxin-1 (GLRX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [167]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [168]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [79]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [27]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [150]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [72]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [169]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [170]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [73]
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Drug Name Drug ID Indication ICD 11 Highest Status REF
Estrone DM5T6US Acne vulgaris ED80 Approved [171]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [171]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Quercetin DM3NC4M Obesity 5B81 Approved [45]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [172]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [173]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [79]
Plicamycin DM7C8YV Hypercalcaemia 5B91.0 Approved [174]
Testosterone DM7HUNW Hot flushes GA30 Approved [87]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [175]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [176]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [94]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [177]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [27]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [70]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [178]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [73]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [179]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [78]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [180]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [101]
Quercetin DM3NC4M Obesity 5B81 Approved [45]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [74]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [181]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [79]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [175]
Leflunomide DMR8ONJ Arthritis FA20 Approved [60]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [90]
Bortezomib DMNO38U Leukemia Approved [182]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [73]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [141]
Selenium DM25CGV N. A. N. A. Approved [82]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [56]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [183]
Panobinostat DM58WKG Chronic graft versus host disease Approved [58]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [50]
Testosterone DM7HUNW Hot flushes GA30 Approved [87]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [59]
Leflunomide DMR8ONJ Arthritis FA20 Approved [60]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [156]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [58]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [184]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [185]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [186]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [124]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [187]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [188]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [189]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [189]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Stanniocalcin-1 (STC1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [68]
Quercetin DM3NC4M Obesity 5B81 Approved [190]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [123]
Panobinostat DM58WKG Chronic graft versus host disease Approved [58]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [151]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [50]
Testosterone DM7HUNW Hot flushes GA30 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [27]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [70]
Ethanol DMDRQZU Chronic pain MG30 Approved [191]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [192]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [94]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [193]
Panobinostat DM58WKG Chronic graft versus host disease Approved [58]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [70]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [72]
Indomethacin DMSC4A7 Bursitis Approved [194]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [195]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [194]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [98]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [100]
Quercetin DM3NC4M Obesity 5B81 Approved [45]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [30]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [100]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [30]
Panobinostat DM58WKG Chronic graft versus host disease Approved [58]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [50]
Testosterone DM7HUNW Hot flushes GA30 Approved [83]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [87]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [196]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [197]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [198]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [58]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [126]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [68]
Trichostatin A DM9C8NX Solid tumour/cancer 2A00-2F9Z Investigative [58]
CHLORPYRIFOS DMKPUI6 Discovery agent N.A. Investigative [199]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [168]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [200]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [97]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [201]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Folic Acid DMEMBJC Colorectal carcinoma Approved [202]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [90]
Bortezomib DMNO38U Leukemia Approved [182]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [203]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Reelin (RELN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [49]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [204]
Panobinostat DM58WKG Chronic graft versus host disease Approved [58]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [75]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [150]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [205]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [73]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [195]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By C-C motif chemokine 20 (CCL20)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [127]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [106]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [128]
Methotrexate DM2TEOL Anterior urethra cancer Approved [129]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [56]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [206]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [129]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [59]
Leflunomide DMR8ONJ Arthritis FA20 Approved [60]
Glutathione DMAHMT9 Human immunodeficiency virus infection 1C62 Approved [51]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [41]
Quercetin DM3NC4M Obesity 5B81 Approved [45]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [123]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [172]
Panobinostat DM58WKG Chronic graft versus host disease Approved [58]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [173]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [64]
Testosterone DM7HUNW Hot flushes GA30 Approved [87]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [59]
Leflunomide DMR8ONJ Arthritis FA20 Approved [60]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [137]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [207]
Quercetin DM3NC4M Obesity 5B81 Approved [102]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [208]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [122]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [209]
Testosterone DM7HUNW Hot flushes GA30 Approved [87]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [210]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [87]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [127]
Quercetin DM3NC4M Obesity 5B81 Approved [45]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [74]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [211]
Panobinostat DM58WKG Chronic graft versus host disease Approved [58]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [200]
Testosterone DM7HUNW Hot flushes GA30 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [61]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [76]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Semaphorin-3A (SEMA3A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [54]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [96]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [27]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [70]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [71]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [72]
Sodium lauryl sulfate DMLJ634 Constipation DD91.1 Approved [160]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [73]
Azacitidine DMTA5OE Acute myelogenous leukaemia 2A41 Approved [212]
Arsenic DMTL2Y1 N. A. N. A. Approved [213]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [192]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [181]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [59]
Leflunomide DMR8ONJ Arthritis FA20 Approved [60]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [75]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [123]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [214]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [73]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [215]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Syntaxin-1A (STX1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [216]
Quercetin DM3NC4M Obesity 5B81 Approved [45]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [56]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [168]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [27]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [150]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [72]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [73]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [162]
Arsenic DMTL2Y1 N. A. N. A. Approved [213]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [127]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [63]
Quercetin DM3NC4M Obesity 5B81 Approved [45]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [217]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [79]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [218]
Leflunomide DMR8ONJ Arthritis FA20 Approved [60]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [75]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [70]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [56]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [74]
Testosterone DM7HUNW Hot flushes GA30 Approved [87]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [87]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [162]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [219]
Urethane DM7NSI0 N. A. N. A. Phase 4 [220]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [221]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [222]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Anoctamin-1 (ANO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [223]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [61]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Folic Acid DMEMBJC Colorectal carcinoma Approved [84]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [205]
Ethinyl Estradiol DMODJ40 Acne vulgaris ED80 Approved [224]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [73]
Nimodipine DMQ0RKZ Cerebral vasospasm BA85.Z Approved [225]
Arsenic DMTL2Y1 N. A. N. A. Approved [226]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [172]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [181]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [50]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [59]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [61]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [227]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [72]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [228]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [188]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [229]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [230]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [187]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [53]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [76]
Arsenic DMTL2Y1 N. A. N. A. Approved [213]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [219]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [180]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [187]
Urethane DM7NSI0 N. A. N. A. Phase 4 [220]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [221]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [126]
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [70]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [72]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [162]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [231]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [232]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [233]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [188]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [234]
PDX-101 DM6OC53 Plasma cell myeloma 2A83.1 Phase 2 [58]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [3]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neuron navigator 3 (NAV3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [49]
Panobinostat DM58WKG Chronic graft versus host disease Approved [58]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [122]
Testosterone DM7HUNW Hot flushes GA30 Approved [87]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [87]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [67]
Folic Acid DMEMBJC Colorectal carcinoma Approved [84]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [85]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [162]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [45]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [49]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [59]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [75]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [76]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [150]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [98]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [124]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [58]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [45]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [74]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [59]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [61]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [72]
Vinblastine DM5TVS3 Advanced cancer 2A00-2F9Z Approved [234]
Mitomycin DMH0ZJE Breast cancer 2C60-2C65 Approved [234]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [234]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [221]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Tribbles homolog 2 (TRIB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [82]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [217]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [181]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [27]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [214]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [72]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [203]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [78]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [235]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Hyaluronan synthase 2 (HAS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [127]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [49]
Panobinostat DM58WKG Chronic graft versus host disease Approved [58]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [151]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [59]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [70]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [71]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [236]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [237]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [162]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [68]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [216]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [49]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [238]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [27]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [70]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [90]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [72]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [85]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [239]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [45]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [74]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [96]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [59]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [75]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [150]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [71]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [72]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [73]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Formin-like protein 2 (FMNL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [56]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [74]
Leflunomide DMR8ONJ Arthritis FA20 Approved [60]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [75]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [150]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [179]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [185]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [27]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [124]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Monoglyceride lipase (MGLL)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [141]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [57]
Testosterone DM7HUNW Hot flushes GA30 Approved [87]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [87]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [27]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [150]
Folic Acid DMEMBJC Colorectal carcinoma Approved [202]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [240]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [72]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [95]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [79]
Leflunomide DMR8ONJ Arthritis FA20 Approved [60]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [45]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [124]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [126]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [176]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [241]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [242]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [57]
Testosterone DM7HUNW Hot flushes GA30 Approved [83]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [59]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [61]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [90]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [72]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [73]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [203]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [215]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [57]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [61]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [62]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [72]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [162]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [243]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [244]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [58]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [188]
Fenfluramine DM0762O Dravet syndrome 8A61.11 Phase 3 [245]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [45]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [246]
Mifepristone DMGZQEF Cushing disease 5A70 Approved [214]
Ampicillin DMHWE7P Acute epiglottitis Approved [45]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [73]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [243]
Arsenic DMTL2Y1 N. A. N. A. Approved [91]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [124]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [247]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [248]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [68]
Panobinostat DM58WKG Chronic graft versus host disease Approved [58]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [70]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [72]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [232]
Topotecan DMP6G8T Central nervous system neoplasm Approved [234]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [58]
(+)-JQ1 DM1CZSJ Testicular cancer 2C80 Phase 1 [221]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [126]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [222]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Neurotrimin (NTM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [49]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [28]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [72]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [85]
Arsenic DMTL2Y1 N. A. N. A. Approved [249]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [219]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [186]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [228]
Triclosan DMZUR4N Malaria 1F40-1F45 Approved [188]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Histone deacetylase 9 (HDAC9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [49]
Panobinostat DM58WKG Chronic graft versus host disease Approved [250]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [79]
Pirfenidone DM6VZFQ Idiopathic pulmonary fibrosis CB03.4 Approved [250]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [251]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [76]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [90]
Indomethacin DMSC4A7 Bursitis Approved [194]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [184]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [68]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [49]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [59]
Leflunomide DMR8ONJ Arthritis FA20 Approved [60]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [27]
Testosterone enanthate DMB6871 N. A. N. A. Approved [252]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [70]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [73]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [63]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [253]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [254]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [255]
Quercetin DM3NC4M Obesity 5B81 Approved [55]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [74]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [256]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [257]
Panobinostat DM58WKG Chronic graft versus host disease Approved [58]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [86]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [258]
Testosterone DM7HUNW Hot flushes GA30 Approved [83]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [259]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [260]
Quercetin DM3NC4M Obesity 5B81 Approved [261]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [223]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [256]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [262]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [263]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [264]
Leflunomide DMR8ONJ Arthritis FA20 Approved [60]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [27]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [265]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [266]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [267]
Gefitinib DM15F0X Colon adenocarcinoma Approved [268]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [122]
Selenium DM25CGV N. A. N. A. Approved [269]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [270]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [255]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [271]
Methotrexate DM2TEOL Anterior urethra cancer Approved [46]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [82]
Quercetin DM3NC4M Obesity 5B81 Approved [45]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [211]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [27]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [58]
Melatonin DMKWFBT Depression 6A70-6A7Z Approved [272]
Pemetrexed DMMX2E6 Central nervous system lymphoma 2B33.5 Approved [273]
Azathioprine DMMZSXQ Lupus nephritis 4A40.0Y Approved [169]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [73]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [274]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [127]
Gefitinib DM15F0X Colon adenocarcinoma Approved [275]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [276]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [277]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [278]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [279]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [278]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [280]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [281]
Methotrexate DM2TEOL Anterior urethra cancer Approved [282]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Fos-related antigen 1 (FOSL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [128]
Quercetin DM3NC4M Obesity 5B81 Approved [45]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [74]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [283]
Chlorpromazine DMBGZI3 Acute intermittent hepatic porphyria 5C58.11 Approved [284]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [285]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [286]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [79]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [287]
Leflunomide DMR8ONJ Arthritis FA20 Approved [60]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [288]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [289]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [290]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [291]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [292]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [293]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [294]
Gefitinib DM15F0X Colon adenocarcinoma Approved [295]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [296]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [297]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [298]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [289]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [299]
Paclitaxel DMLB81S Breast carcinoma Approved [300]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [301]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [288]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [302]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [105]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [291]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [292]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [303]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [304]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [305]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [306]
Gefitinib DM15F0X Colon adenocarcinoma Approved [307]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [308]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [309]
Selenium DM25CGV N. A. N. A. Approved [82]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [310]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [270]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [311]
Methotrexate DM2TEOL Anterior urethra cancer Approved [101]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [312]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [313]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [314]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [315]
Testosterone DM7HUNW Hot flushes GA30 Approved [316]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [317]
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [303]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [27]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [318]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [319]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [319]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [320]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [321]
Ceftazidime DM41GRA Bacteremia 1A73 Approved [319]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [74]
Chlorpheniramine DM5URA2 Allergic rhinitis CA08.0 Approved [319]
Ethacrynic acid DM60QMR Edema MG29 Approved [319]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [319]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [291]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [153]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [322]
Methotrexate DM2TEOL Anterior urethra cancer Approved [323]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [324]
Quercetin DM3NC4M Obesity 5B81 Approved [325]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [326]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [153]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [327]
Ethacrynic acid DM60QMR Edema MG29 Approved [328]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [329]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [69]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [330]
Methotrexate DM2TEOL Anterior urethra cancer Approved [54]
Quercetin DM3NC4M Obesity 5B81 Approved [331]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [57]
Levamisole DM5EN79 Parasitic infection 1D0Y-1G2Z Approved [332]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [333]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [334]
Promethazine DM6I5GR Hyperemesis gravidarum Approved [335]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [86]
Testosterone DM7HUNW Hot flushes GA30 Approved [83]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [336]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [62]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [337]
Arsenic DMTL2Y1 N. A. N. A. Approved [338]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [195]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [124]
Bortezomib DMNO38U Leukemia Approved [339]
Curcumin DMQPH29 Solid tumour/cancer 2A00-2F9Z Phase 3 [340]
⏷ Show the Full List of 10 Drug(s)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [341]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [342]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [57]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [343]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [344]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [342]
Ursodeoxycholic acid DMCUT21 Cholelithiasis DC11 Approved [345]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [150]
Ethanol DMDRQZU Chronic pain MG30 Approved [346]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [347]
⏷ Show the Full List of 10 Drug(s)

Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
MAPK/ERK kinase kinase (MAP3K) TTROQ37 NOUNIPROTAC Modulator [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
17-beta-hydroxysteroid dehydrogenase type 2 (HSD17B2) OT3K7HY5 DHB2_HUMAN Gene/Protein Processing [3]
5-hydroxytryptamine receptor 7 (HTR7) OT44DEWB 5HT7R_HUMAN Gene/Protein Processing [3]
A-kinase anchor protein 12 (AKAP12) OTCVRDDX AKA12_HUMAN Gene/Protein Processing [3]
ADP-ribosylation factor-like protein 4C (ARL4C) OTQ3QNNU ARL4C_HUMAN Gene/Protein Processing [3]
Aminopeptidase N (ANPEP) OTP3WYFD AMPN_HUMAN Gene/Protein Processing [3]
Anoctamin-1 (ANO1) OTSREUNI ANO1_HUMAN Gene/Protein Processing [3]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Gene/Protein Processing [4]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Gene/Protein Processing [5]
C-C motif chemokine 20 (CCL20) OTUCJY4N CCL20_HUMAN Gene/Protein Processing [3]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Gene/Protein Processing [6]

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7935).
2 MEK and the inhibitors: from bench to bedside. J Hematol Oncol. 2013; 6: 27.
3 PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies. Nature. 2014 Oct 9;514(7521):247-51.
4 Blocking downstream signaling pathways in the context of HDAC inhibition promotes apoptosis preferentially in cells harboring mutant Ras. Oncotarget. 2016 Oct 25;7(43):69804-69815. doi: 10.18632/oncotarget.12001.
5 Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer. Cancer Lett. 2014 Jun 1;347(2):204-11. doi: 10.1016/j.canlet.2014.02.018. Epub 2014 Feb 24.
6 U0126, a mitogen-activated protein kinase kinase 1 and 2 (MEK1 and 2) inhibitor, selectively up-regulates main isoforms of CYP3A subfamily via a pregnane X receptor (PXR) in HepG2 cells. Arch Toxicol. 2014 Dec;88(12):2243-59.
7 Radium 223 dichloride for prostate cancer treatment. Drug Des Devel Ther. 2017 Sep 6;11:2643-2651.
8 RDEA119/BAY 869766: a potent, selective, allosteric inhibitor of MEK1/2 for the treatment of cancer.Cancer Res.2009 Sep 1;69(17):6839-47.
9 Intrinsic resistance to selumetinib, a selective inhibitor of MEK1/2, by cAMP-dependent protein kinase A activation in human lung and colorectal cancer cells.Br J Cancer.2012 May 8;106(10):1648-59.
10 Antitumor activity of pimasertib, a selective MEK 1/2 inhibitor, in combination with PI3K/mTOR inhibitors or with multi-targeted kinase inhibitors in pimasertib-resistant human lung and colorectal cancer cells. Int J Cancer. 2013 Nov;133(9):2089-101.
11 The dual RAF/MEK inhibitor CH5126766/RO5126766 may be a potential therapy for RAS-mutated tumor cells.PLoS One.2014 Nov 25;9(11):e113217.
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57 Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
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59 Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
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66 The Bromodomain Inhibitor JQ1 and the Histone Deacetylase Inhibitor Panobinostat Synergistically Reduce N-Myc Expression and Induce Anticancer Effects. Clin Cancer Res. 2016 May 15;22(10):2534-44. doi: 10.1158/1078-0432.CCR-15-1666. Epub 2016 Jan 5.
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70 Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
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72 Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
73 Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
74 Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
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76 Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
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82 Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
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101 Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
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104 Atorvastatin affects several angiogenic mediators in human endothelial cells. Endothelium. 2005 Sep-Dec;12(5-6):233-41.
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