General Information of DME (ID: DE5IED8)

DME Name Cytochrome P450 2C9 (CYP2C9) DME Info
UniProt ID
CP2C9_HUMAN
Gene Name CYP2C9

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Discontinued Drug(s)
Investigative Drug(s)
211 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Aceclofenac DMZDF0B Inflammation 1A00-CA43.1 Approved [1]
Acenocoumarol DMH75KV Thrombosis DB61-GB90 Approved [2]
Acetaminophen DMUIE76 Pain MG30-MG3Z Approved [3]
Acetohexamide DMR6N7H Diabetic complication 5A2Y Approved [4]
Alosetron DML2A03 Irritable bowel syndrome DD91.0 Approved [5]
Alprazolam DMC7XDN Anxiety disorder 6B00-6B0Z Approved [6]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [6]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [7]
Amprenavir DMLMXE0 Human immunodeficiency virus infection 1C62 Approved [8]
Apixaban DM89JLN Thrombosis DB61-GB90 Approved [9]
Artemether DM48QOT Malaria 1F40-1F45 Approved [10]
Aspirin DM672AH Myocardial infarction BA41-BA43 Approved [11]
Atazanavir DMSYRBX Human immunodeficiency virus infection 1C62 Approved [12]
Azelastine DMXTMBJ Allergic conjunctivitis 9A60.02 Approved [13]
Benzbromarone DMC3YUA Gout FA25 Approved [14]
Bexarotene DMOBIKY Cutaneous T-cell lymphoma 2B01 Approved [3]
Bortezomib DMNO38U Mantle cell lymphoma 2A85.5 Approved [15]
Bosentan DMIOGBU Pulmonary arterial hypertension BB01.0 Approved [16]
Brivaracetam DMSEPK8 Complex partial seizure 8A68.0 Approved [17]
Bromfenac DMKB79O Postoperative inflammation 1A00-CA43.1 Approved [18]
Buprenorphine DMPRI8G Pain MG30-MG3Z Approved [6]
Bupropion DM5PCS7 Smoking dependence 6C4A.2 Approved [19]
Cabozantinib DMIYDT4 Thyroid cancer 2D10 Approved [20]
Caffeine DMKBJWP Orthostatic hypotension BA21 Approved [21]
Candesartan DMRK8OT Hypertension BA00-BA04 Approved [22]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [23]
Capsaicin DMGMF6V Neuropathic pain 8E43.0 Approved [24]
Carvedilol DMHTEAO Congestive heart failure BD10 Approved [25]
Celecoxib DM6LOQU Rheumatoid arthritis FA20 Approved [26]
Chlorpropamide DMPHZQE Non-insulin dependent diabetes 5A11 Approved [27]
Cinnarizine DM7U5QJ Vertigo meniere disease AB31.0 Approved [6]
Cisapride DMY7PED Gastroesophageal reflux disease DA22.Z Approved [28]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [29]
Clopidogrel DMOL54H Thrombosis DB61-GB90 Approved [30]
Clozapine DMFC71L Schizophrenia 6A20 Approved [31]
Cyclophosphamide DM4O2Z7 Solid tumour/cancer 2A00-2F9Z Approved [32]
Dacomitinib DMOH8VY Non-small-cell lung cancer 2C25.Y Approved [33]
Dapagliflozin DM28UJG Type-2 diabetes 5A11 Approved [34]
Dapsone DM4LT8A Pneumocystis pneumonia CA40.20 Approved [35]
Desogestrel DM27U4Y Contraception QA21 Approved [36]
Dexibuprofen DMFYBD0 Ankylosing spondylitis FA92.0 Approved [37]
Dextromethorphan DMUDJZM Cough MD12 Approved [38]
Diazepam DM08E9O Epilepsy 8A60-8A68 Approved [39]
Diclofenac DMPIHLS Osteoarthritis FA00-FA05 Approved [37]
Dicumarol DMFQCB1 Bleeding disorder GA20-GA21 Approved [40]
Diltiazem DMAI7ZV Hypertension BA00-BA04 Approved [41]
Diphenhydramine DMKQTBA Meniere disease AB31.0 Approved [42]
Dolasetron DMMG26Z Nausea MD90 Approved [3]
Donepezil DMIYG7Z Alzheimer disease 8A20 Approved [43]
Dopamine DMPGUCF Parkinson disease 8A00.0 Approved [44]
Dorzolamide DMA17D0 Open-angle glaucoma 9C61 Approved [3]
Doxazosin DM9PLRH Hypertension BA00-BA04 Approved [45]
Doxepin DMPI98T Depression 6A70-6A7Z Approved [46]
Duloxetine DM9BI7M Depression 6A70-6A7Z Approved [47]
Eicosapentaenoic acid/docosa-hexaenoic acid DMMUCG4 Hypertriglyceridemia 5C80.1 Approved [48]
Eletriptan DMW649X Migraine 8A80 Approved [49]
Enasidenib DM8QXOC Acute myeloid leukaemia 2A60 Approved [50]
Epoprostenol DMUTYR2 Pulmonary hypertension BB01 Approved [51]
Erdafitinib DMI782S Bladder cancer 2C94 Approved [52]
Ergotidine DM78IME Respiratory allergy 4A80 Approved [12]
Estradiol DMUNTE3 Breast cancer 2C60-2C65 Approved [53]
Estradiol acetate DM07U2A Hormone replacement therapy 8E01 Approved [54]
Estradiol cypionate DM27Z5T Hormone replacement therapy 8E01 Approved [54]
Estradiol valerate DM8MC6O Hormone replacement therapy 8E01 Approved [54]
Estrone DM5T6US Menopausal and postmenopausal disorder GA30 Approved [54]
Ethinyl estradiol DMODJ40 Female hypogonadism GA30.6 Approved [55]
Etodolac DM6WJO9 Pain MG30-MG3Z Approved [56]
Etoricoxib DM6A4NW Rheumatoid arthritis FA20 Approved [57]
Etravirine DMGV8QU Human immunodeficiency virus-1 infection 1C62 Approved [58]
Fluconazole DMOWZ6B Fungal infection 1F29-1F2F Approved [59]
Flunarizine DMZU5JP Migraine 8A80 Approved [29]
Flunitrazepam DMGR5Z3 Insomnia 7A00-7A0Z Approved [60]
Fluoxetine DM3PD2C Depression 6A70-6A7Z Approved [61]
Flurbiprofen DMGN4BY Rheumatoid arthritis FA20 Approved [62]
Fluvastatin DM4MDJY Hypercholesterolaemia 5C80.0 Approved [63]
Formoterol DMSOURV Asthma CA23 Approved [64]
Fosphenytoin DMOX3LB Epilepsy 8A60-8A68 Approved [6]
Glibenclamide DM8JXPZ Diabetic complication 5A2Y Approved [65]
Gliclazide DMN6QO5 Diabetic complication 5A2Y Approved [6]
Glimepiride DM5FSJA Diabetic complication 5A2Y Approved [66]
Glipizide DMZA5PQ Diabetic complication 5A2Y Approved [67]
Gliquidone DMB0EUX Diabetic complication 5A2Y Approved [4]
Glisoxepide DMJPR2B Non-insulin dependent diabetes 5A11 Approved [4]
Haloperidol DM96SE0 Schizophrenia 6A20 Approved [68]
Halothane DM80OZ5 Anaesthesia 9A78.6 Approved [69]
Hexobarbital DMQ314B Anaesthesia 9A78.6 Approved [3]
Hydromorphone DMHP21E Pain MG30-MG3Z Approved [70]
Ibuprofen DM8VCBE Pain MG30-MG3Z Approved [3]
Idarubicin DMM0XGL Acute myeloid leukaemia 2A60 Approved [71]
Ifosfamide DMCT3I8 Solid tumour/cancer 2A00-2F9Z Approved [32]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [72]
Indomethacin DMSC4A7 Rheumatoid arthritis FA20 Approved [6]
Irbesartan DMTP1DC Hypertension BA00-BA04 Approved [73]
Istradefylline DM20VSK Parkinson disease 8A00.0 Approved [74]
Ketamine DMT5HA4 Anaesthesia 9A78.6 Approved [75]
Ketobemidone DMM3L6Z Pain MG30-MG3Z Approved [76]
Ketoprofen DMRKXPT Musculoskeletal pain MG30 Approved [77]
Lacosamide DMVM6QR Convulsion 8A68.Z Approved [78]
Lansoprazole DMXYLQ3 Duodenal ulcer DA63 Approved [6]
Leflunomide DMR8ONJ Arthritis FA20 Approved [79]
Lesinurad DMUR64T Hyperuricaemia 5C55.Y Approved [80]
Lidocaine DML4ZOT Anaesthesia 9A78.6 Approved [3]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [81]
Lornoxicam DMYZFXN Migraine 8A80 Approved [2]
Losartan DM72JXH Hypertension BA00-BA04 Approved [6]
Lumiracoxib DM1S4AG Knee osteoarthritis FA01 Approved [82]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [83]
Mefenamic acid DMK7HFI Dysmenorrhea GA34.3 Approved [84]
Melatonin DMKWFBT Insomnia 7A00-7A0Z Approved [37]
Meloxicam DM2AR7L Arthritis FA20 Approved [3]
Mephenytoin DM5UGDK Epilepsy 8A60-8A68 Approved [85]
Mestranol DMG3F94 Contraception QA21 Approved [6]
Methadone DMTW6IU Dry cough MD12 Approved [86]
Methoxyflurane DML0RAE Anaesthesia 9A78.6 Approved [87]
Metronidazole DMTIVEN Amoebiasis 1A36 Approved [3]
Mirtazapine DML53ZJ Depression 6A70-6A7Z Approved [3]
Moclobemide DMNZWL7 Depression 6A70-6A7Z Approved [3]
Montelukast DMD157S Asthma CA23 Approved [88]
Nabumetone DMAT2XH Pain MG30-MG3Z Approved [89]
Naftopidil DMQ8R4E Hypertension BA00-BA04 Approved [90]
Naproxen DMZ5RGV Osteoarthritis FA00-FA05 Approved [26]
Nateglinide DMLK2QH Diabetic complication 5A2Y Approved [91]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [92]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [93]
Nicotine DMWX5CO Nicotine dependence 6C4A.2 Approved [94]
Olodaterol DM62B78 Chronic obstructive pulmonary disease CA22 Approved [95]
Omeprazole DM471KJ Gastroesophageal reflux disease DA22.Z Approved [96]
Ondansetron DMOTQ1I Chemotherapy-induced nausea MD90 Approved [3]
Ospemifene DMC4GEI Dyspareunia GA12 Approved [97]
Oxaprozin DM9UB0P Rheumatoid arthritis FA20 Approved [98]
Paramethadione DMR5ZUP Fetal trimethadione syndrome LD2F.0Y Approved [99]
Perazine DM2AOTZ Psychotic disorder 6A20-6A25 Approved [100]
Perphenazine DMA4MRX Schizophrenia 6A20 Approved [101]
Phenobarbital DMXZOCG Seizure disorder 8A6Z Approved [102]
Phenprocoumon DMDO279 Thrombosis DB61-GB90 Approved [103]
Phenylbutazone DMAYL0T Chronic pain MG30 Approved [104]
Phenytoin DMNOKBV Epilepsy 8A60-8A68 Approved [105]
Pioglitazone DMKJ485 Diabetic complication 5A2Y Approved [106]
Piperaquine DMT70RC Malaria 1F40-1F45 Approved [107]
Piroxicam DMTK234 Pain MG30-MG3Z Approved [108]
Pitavastatin calcium DM1UJO0 Dyslipidemia 5C80-5C81 Approved [109]
Prasugrel DM7MT6E Acute coronary syndrome BA41 Approved [110]
Pravastatin DM6A0X7 Hypercholesterolaemia 5C80.0 Approved [111]
Primidone DM0WX6I Epilepsy 8A60-8A68 Approved [112]
Progesterone DMUY35B Premature labour JB00 Approved [113]
Proguanil DMBL79I Malaria 1F40-1F45 Approved [3]
Promazine DMZAL7W Psychomotor agitation MB23.M Approved [6]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [114]
Quazepam DMY4D87 Insomnia 7A00-7A0Z Approved [115]
Quinidine DMLPICK Tachyarrhythmias BC71 Approved [116]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [117]
Rifampicin DM5DSFZ Osteoporosis FB83.0 Approved [6]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [118]
Rosiglitazone DMY6EAO Type-2 diabetes 5A11 Approved [119]
Rosuvastatin DMMIQ7G Hypercholesterolaemia 5C80.0 Approved [120]
Salicyclic acid DM2F8XZ Seborrhoeic dermatitis EA81 Approved [121]
Selegiline hydrochloride DM3VR1L Parkinson disease 8A00.0 Approved [3]
Sertraline DM0FB1J Depression 6A70-6A7Z Approved [122]
Sildenafil citrate DMSWJ5X Erectile dysfunction HA01.1 Approved [6]
Siponimod DMVCMUJ Multiple sclerosis 8A40 Approved [123]
Siponimod DM2R86O Multiple sclerosis 8A40 Approved [123]
Sulfadiazine DMTW3R8 Rheumatic fever 1B40-1B42 Approved [124]
Sulfamethoxazole DMB08GE Bacterial infection 1A00-1C4Z Approved [125]
Sulfisoxazole DMXLT8C Urinary tract infection GC08 Approved [124]
Suprofen DMKXJZ7 Miosis LA11.62 Approved [126]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [127]
Tapentadol hydrochloride DMXLSH3 Acute pain MG31 Approved [128]
Temazepam DM02A65 Insomnia 7A00-7A0Z Approved [129]
Tenoxicam DMVAZP9 Rheumatoid arthritis FA20 Approved [130]
Terbinafine DMI6HUW Fungal infection 1F29-1F2F Approved [6]
Testosterone cypionate DMC1TEV Testosterone deficiency 5A81.1 Approved [131]
Testosterone enanthate DMB6871 Testosterone deficiency 5A81.1 Approved [131]
Testosterone Undecanoate DMZO10Y Hypogonadism 5A61.0 Approved [131]
Thalidomide DM70BU5 Multiple myeloma 2A83 Approved [132]
Thiamylal DMHDF7B Anaesthesia 9A78.6 Approved [133]
Tolazamide DMIHRNA Diabetic complication 5A2Y Approved [4]
Tolbutamide DM02AWV Non-insulin dependent diabetes 5A11 Approved [134]
Tolterodine DMSHPW8 Overactive bladder GC50.0 Approved [135]
Torasemide DMXKJ6C Congestive heart failure BD10 Approved [6]
Trabectedin DMG3Y89 Solid tumour/cancer 2A00-2F9Z Approved [136]
Tranilast DME5Y64 Ocular allergy 4A81 Approved [137]
Treprostinil DMTIQF3 Pulmonary arterial hypertension BB01.0 Approved [138]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [3]
Triclabendazole DMPWGBR Helminth infection 1F90.0 Approved [139]
Trifarotene DMOL793 Acne vulgaris ED80 Approved [140]
Trimethadione DM0Q8MZ Epilepsy 8A60-8A68 Approved [99]
Trimethoprim DMM7CHK Urinary tract infection GC08 Approved [141]
Trimipramine DM1SC8M Major depressive disorder 6A70.3 Approved [142]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [143]
Tropisetron DMNSJ7V Fibromyalgia MG30.01 Approved [3]
Valdecoxib DMAY7H4 Osteoarthritis FA00-FA05 Approved [144]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [145]
Valsartan DMREUQ6 Hypertension BA00-BA04 Approved [146]
Venlafaxine DMR6QH0 Depression 6A70-6A7Z Approved [147]
Verapamil DMA7PEW Hypertension BA00-BA04 Approved [41]
Vismodegib DM5IXKQ Basal cell carcinoma 2C32 Approved [148]
Voriconazole DMAOL2S Invasive aspergillosis 1F20.0 Approved [149]
Vortioxetine DM6F1PU Major depressive disorder 6A70.3 Approved [150]
Voxelotor DMCS6M5 Sickle-cell disorder 3A51 Approved [151]
Warfarin DMJYCVW Atrial fibrillation BC81.3 Approved [152]
Zafirlukast DMHNQOG Asthma CA23 Approved [153]
Zalcitabine DMH7MUV Human immunodeficiency virus infection 1C62 Approved [154]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [3]
Zileuton DMVRIC2 Asthma CA23 Approved [155]
Zolpidem DMWOSKJ Insomnia 7A00-7A0Z Approved [156]
Zopiclone DMPI6Z0 Insomnia 7A00-7A0Z Approved [157]
Aminophenazone DMY2AH1 Anaesthesia 9A78.6 Phase 4 [6]
Imrecoxib DMVXLOD N. A. N. A. Phase 4 [158]
Lynestrenol DM82JP0 N. A. N. A. Phase 4 [159]
Rupatadine DMBPN7T N. A. N. A. Phase 4 [160]
Zaltoprofen DM9RJH7 Anaesthesia 9A78.6 Phase 4 [6]
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⏷ Show the Full List of 211 Approved Drug(s)
17 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Esketamine DMVU687 Depression 6A70-6A7Z Phase 3 [75]
Iclaprim DM7YNV9 Bacterial infection 1A00-1C4Z Phase 3 [161]
Momelotinib DMF98Q0 Myelofibrosis 2A20.2 Phase 3 [162]
Muraglitazar DMG3NFZ N. A. N. A. Phase 3 [163]
Nabiximols DMHKJ5I Cancer related pain MG30 Phase 3 [23]
Netupitant DMEKAYI Chemotherapy-induced nausea MD90 Phase 3 [164]
Vicriviroc DMMTW9K Human immunodeficiency virus infection 1C62 Phase 3 [6]
Sarizotan DMH7IPW Rett syndrome LD90.4 Phase 2/3 [165]
BMS 650032 DMQI43G Hepatitis C virus infection 1E51.1 Phase 2 [166]
Dexloxiglumide DM52HUD Pancreatic malfunction DC30-DC3Z Phase 2 [167]
Ferroquine DMICMXE Malaria 1F40-1F45 Phase 2 [168]
Indisulam DM9SX6Y Lymphoma 2A80-2A86 Phase 2 [169]
CC-223 DMMQYL9 Solid tumour/cancer 2A00-2F9Z Phase 1/2 [170]
H3B-6545 DMIFCY2 Breast cancer 2C60-2C65 Phase 1/2 [171]
BZ-55 DMH6B9J Type-2 diabetes 5A11 Phase 1 [4]
Capravirine DM9ERH1 Human immunodeficiency virus infection 1C62 Phase 1 [172]
HSP-990 DML6HP3 Solid tumour/cancer 2A00-2F9Z Phase 1 [173]
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⏷ Show the Full List of 17 Clinical Trial Drug(s)
7 Discontinued Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Phenacetin DMRQAM0 Analgesia MB40.8 Withdrawn from market [174]
Sitaxsentan DMKM5HB Pulmonary arterial hypertension BB01.0 Withdrawn from market [175]
Terfenadine DM4KLPT Allergy 4A80-4A85 Withdrawn from market [176]
Ticrynafen DMLFSTR Congestive heart failure BD10 Withdrawn from market [177]
Ximelagatran DMABRJL Coagulation defect 3B10.0 Withdrawn from market [178]
Seratrodast DMPNTDL Allergic asthma CA23.0 Discontinued in Phase 3 [3]
Licofelone DM7HLFD Osteoarthritis FA00-FA05 Discontinued in Phase 1 [6]
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⏷ Show the Full List of 7 Discontinued Drug(s)
5 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arachidonic acid DMUOQZD Discovery agent N.A. Investigative [37]
Coumarin DM0N8ZM Discovery agent N.A. Investigative [152]
Cyamemazine DMZ6YPV Discovery agent N.A. Investigative [179]
Phenazone DMCE985 Discovery agent N.A. Investigative [6]
[3H]estrone-3-sulphate DMGPF0N Discovery agent N.A. Investigative [152]
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Molecule Interaction Atlas

References

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54 A potential role for the estrogen-metabolizing cytochrome P450 enzymes in human breast carcinogenesis. Breast Cancer Res Treat. 2003 Dec;82(3):191-7.
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56 Stereoselective glucuronidation and hydroxylation of etodolac by UGT1A9 and CYP2C9 in man. Xenobiotica. 2004 May;34(5):449-61.
57 Role of human liver cytochrome P4503A in the metabolism of etoricoxib, a novel cyclooxygenase-2 selective inhibitor. Drug Metab Dispos. 2001 Jun;29(6):813-20.
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70 Role of individual human cytochrome P450 enzymes in the in vitro metabolism of hydromorphone. Xenobiotica. 2004 Apr;34(4):335-44.;
71 In vitro evaluation of cytochrome P450-mediated drug interactions between cytarabine, idarubicin, itraconazole and caspofungin. Hematology. 2004 Jun;9(3):217-21.
72 Drug-drug interactions with imatinib: an observational study. Medicine (Baltimore). 2016 Oct;95(40):e5076.
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76 Ketobemidone is a substrate for cytochrome P4502C9 and 3A4, but not for P-glycoprotein. Xenobiotica. 2005 Aug;35(8):785-96.
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98 Oxaprozin and piroxicam, nonsteroidal antiinflammatory drugs with long half-lives: effect of protein-binding differences on steady-state pharmacokinetics. J Clin Pharmacol. 1997 Apr;37(4):267-78.
99 Involvement of cytochrome P450 2C9, 2E1 and 3A4 in trimethadione N-demethylation in human microsomes. J Clin Pharm Ther. 2003 Dec;28(6):493-6.
100 Cytochrome P-450 enzymes and FMO3 contribute to the disposition of the antipsychotic drug perazine in vitro. Psychopharmacology (Berl). 2000 Sep;151(4):312-20.
101 Identification of the human cytochrome P450 isoforms mediating in vitro N-dealkylation of perphenazine. Br J Clin Pharmacol. 2000 Dec;50(6):563-71.
102 Induction of human CYP2C9 by rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptor. J Pharmacol Exp Ther. 2004 Feb;308(2):495-501.
103 Genetic polymorphisms of cytochrome P450 2C9 causing reduced phenprocoumon (S)-7-hydroxylation in vitro and in vivo. Xenobiotica. 2004 Sep;34(9):847-59.
104 Metabolism of sulfinpyrazone sulfide and sulfinpyrazone by human liver microsomes and cDNA-expressed cytochrome P450s. Drug Metab Dispos. 2001 May;29(5):701-11.
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113 Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes. Arch Biochem Biophys. 1997 Oct 1;346(1):161-9.
114 Cytochrome P-450 2B6 is responsible for interindividual variability of propofol hydroxylation by human liver microsomes. Anesthesiology. 2001 Jan;94(1):110-9.
115 Interaction between grapefruit juice and hypnotic drugs: comparison of triazolam and quazepam. Eur J Clin Pharmacol. 2006 Mar;62(3):209-15.
116 Effect of diclofenac, disulfiram, itraconazole, grapefruit juice and erythromycin on the pharmacokinetics of quinidine. Br J Clin Pharmacol. 1999 Dec;48(6):829-38.
117 Identification of human cytochrome P450 isoforms involved in the 3-hydroxylation of quinine by human live microsomes and nine recombinant human cytochromes P450. J Pharmacol Exp Ther. 1996 Dec;279(3):1327-34.
118 Impact of CYP2C9 genotype on pharmacokinetics: are all cyclooxygenase inhibitors the same? Drug Metab Dispos. 2005 Nov;33(11):1567-75.
119 Characterization of the cytochrome P450 enzymes involved in the in vitro metabolism of rosiglitazone. Br J Clin Pharmacol. 1999 Sep;48(3):424-32.
120 Effects of acid and lactone forms of eight HMG-CoA reductase inhibitors on CYP-mediated metabolism and MDR1-mediated transport. Pharm Res. 2006 Mar;23(3):506-12.
121 Aromatic hydroxylation of salicylic acid and aspirin by human cytochromes P450. Eur J Pharm Sci. 2015 Jun 20;73:49-56.
122 Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: an in vitro study. Drug Metab Dispos. 2005 Feb;33(2):262-70.
123 Metabolism and disposition of siponimod, a novel selective S1P1/S1P5 agonist, in healthy volunteers and in vitro identification of human cytochrome P450 enzymes involved in its oxidative metabolism. Drug Metab Dispos. 2018 Jul;46(7):1001-1013.
124 Prediction of in vivo drug-drug interactions between tolbutamide and various sulfonamides in humans based on in vitro experiments. Drug Metab Dispos. 2000 Apr;28(4):475-81.
125 Reduction of sulfamethoxazole and dapsone hydroxylamines by a microsomal enzyme system purified from pig liver and pig and human liver microsomes. Life Sci. 2005 May 27;77(2):205-19.
126 Mechanism-based inactivation of human recombinant P450 2C9 by the nonsteroidal anti-inflammatory drug suprofen. Drug Metab Dispos. 2003 Nov;31(11):1369-77.
127 Tamoxifen inhibits cytochrome P450 2C9 activity in breast cancer patients. J Chemother. 2006 Aug;18(4):421-4.
128 Investigations into the drug-drug interaction potential of tapentadol in human liver microsomes and fresh human hepatocytes. Drug Metab Lett. 2008 Jan;2(1):67-75.
129 Role of cDNA-expressed human cytochromes P450 in the metabolism of diazepam. Biochem Pharmacol. 1998 Mar 15;55(6):889-96.
130 CYP2C9 genotypes and the pharmacokinetics of tenoxicam in Brazilians. Clin Pharmacol Ther. 2004 Jul;76(1):18-26.
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133 Protein binding and the metabolism of thiamylal enantiomers in vitro. Anesth Analg. 2000 Sep;91(3):736-40.
134 Effects of organic solvents on the activities of cytochrome P450 isoforms, UDP-dependent glucuronyl transferase, and phenol sulfotransferase in human hepatocytes. Drug Metab Dispos. 2001 Feb;29(2):141-4.
135 Tolterodine, a new muscarinic receptor antagonist, is metabolized by cytochromes P450 2D6 and 3A in human liver microsomes. Drug Metab Dispos. 1998 Apr;26(4):289-93.
136 In vitro characterization of the human biotransformation and CYP reaction phenotype of ET-743 (Yondelis, Trabectidin), a novel marine anti-cancer drug. Invest New Drugs. 2006 Jan;24(1):3-14.
137 Glucuronidation of antiallergic drug, Tranilast: identification of human UDP-glucuronosyltransferase isoforms and effect of its phase I metabolite. Drug Metab Dispos. 2007 Apr;35(4):583-9.
138 Lack of a pharmacokinetic interaction between oral treprostinil and bosentan in healthy adult volunteers. J Clin Pharmacol. 2010 Jul;50(7):829-34.
139 In vitro drug-drug interaction potential of sulfoxide and/or sulfone metabolites of albendazole, triclabendazole, aldicarb, methiocarb, montelukast and ziprasidone. Drug Metab Lett. 2018;12(2):101-116.
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142 Effects of polymorphisms in CYP2D6, CYP2C9, and CYP2C19 on trimipramine pharmacokinetics. J Clin Psychopharmacol. 2003 Oct;23(5):459-66.
143 In vitro inhibitory effects of troglitazone and its metabolites on drug oxidation activities of human cytochrome P450 enzymes: comparison with pioglitazone and rosiglitazone. Xenobiotica. 2000 Jan;30(1):61-70.
144 Genetically based impairment in CYP2C8- and CYP2C9-dependent NSAID metabolism as a risk factor for gastrointestinal bleeding: is a combination of pharmacogenomics and metabolomics required to improve personalized medicine? Expert Opin Drug Metab Toxicol. 2009 Jun;5(6):607-20.
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146 In vitro inhibition screening of human hepatic P450 enzymes by five angiotensin-II receptor antagonists. Eur J Clin Pharmacol. 2000 May;56(2):135-40.
147 O- and N-demethylation of venlafaxine in vitro by human liver microsomes and by microsomes from cDNA-transfected cells: effect of metabolic inhibitors and SSRI antidepressants. Neuropsychopharmacology. 1999 May;20(5):480-90.
148 The dawn of hedgehog inhibitors: Vismodegib. J Pharmacol Pharmacother. 2013 Jan;4(1):4-7.
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154 Protease inhibitors in patients with HIV disease. Clinically important pharmacokinetic considerations. Clin Pharmacokinet. 1997 Mar;32(3):194-209.
155 Identification of the human liver cytochrome P450 enzymes involved in the metabolism of zileuton (ABT-077) and its N-dehydroxylated metabolite, Abbott-66193. Drug Metab Dispos. 1995 Oct;23(10):1163-74.
156 The influences of CYP2C9*1/*3 genotype on the pharmacokinetics of zolpidem. Arch Pharm Res. 2018 Sep;41(9):931-936.
157 Cytochrome P-450 3A4 and 2C8 are involved in zopiclone metabolism. Drug Metab Dispos. 1999 Sep;27(9):1068-73.
158 Lack of effect of Imrecoxib, an innovative and moderate COX-2 inhibitor, on pharmacokinetics and pharmacodynamics of warfarin in healthy volunteers. Sci Rep. 2019 Oct 31;9(1):15774.
159 Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone. J Steroid Biochem Mol Biol. 2008 May;110(1-2):56-66.
160 Product Monograph of Xtandi Rupatadine (as rupatadine fumarate).
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162 Pharmacokinetics and disposition of momelotinib revealed a disproportionate human metabolite-resolution for clinical development. Drug Metab Dispos. 2018 Mar;46(3):237-247.
163 Involvement of multiple cytochrome P450 and UDP-glucuronosyltransferase enzymes in the in vitro metabolism of muraglitazar. Drug Metab Dispos. 2007 Jan;35(1):139-49.
164 Effect of netupitant, a highly selective NK?receptor antagonist, on the pharmacokinetics of palonosetron and impact of the fixed dose combination of netupitant and palonosetron when coadministered with ketoconazole, rifampicin, and oral contraceptives. Support Care Cancer. 2013 Oct;21(10):2879-87.
165 In vitro characterization of sarizotan metabolism: hepatic clearance, identification and characterization of metabolites, drug-metabolizing enzyme identification, and evaluation of cytochrome p450 inhibition. Drug Metab Dispos. 2010 Jun;38(6):905-16.
166 Australian Public Assessment Report for asunaprevir.
167 Pharmacokinetic profile of dexloxiglumide. Clin Pharmacokinet. 2006;45(12):1177-88.
168 In vitro metabolism of ferroquine (SSR97193) in animal and human hepatic models and antimalarial activity of major metabolites on Plasmodium falciparum. Drug Metab Dispos. 2006 Apr;34(4):667-82.
169 PK/PD model of indisulam and capecitabine: interaction causes excessive myelosuppression. Clin Pharmacol Ther. 2008 Jun;83(6):829-39.
170 Assessment of drug-drug interaction potential and PBPK modeling of CC-223, a potent inhibitor of the mammalian target of rapamycin kinase. Xenobiotica. 2019 Jan;49(1):54-70.
171 Nonclinical pharmacokinetics and in vitro metabolism of H3B-6545, a novel selective ERalpha covalent antagonist (SERCA). Cancer Chemother Pharmacol. 2019 Jan;83(1):151-160.
172 Identification of enzymes responsible for primary and sequential oxygenation reactions of capravirine in human liver microsomes. Drug Metab Dispos. 2006 Nov;34(11):1798-802.
173 A first-in-human phase I, dose-escalation, multicentre study of HSP990 administered orally in adult patients with advanced solid malignancies. Br J Cancer. 2015 Feb 17;112(4):650-9.
174 Activation of phenacetin O-deethylase activity by alpha-naphthoflavone in human liver microsomes. Xenobiotica. 1999 Sep;29(9):885-98.
175 Interaction of acenocoumarol and sitaxentan in pulmonary arterial hypertension. Eur J Clin Invest. 2009 Jun;39 Suppl 2:14-8.
176 Effects of serum albumin and liver cytosol on CYP2C9- and CYP3A4-mediated drug metabolism. Drug Metab Pharmacokinet. 2002;17(6):522-31.
177 Cytochrome P450 enzymes and UDP-glucuronosyltransferases as hepatocellular autoantigens. Mol Biol Rep. 1996;23(3-4):235-42.
178 Comparative pharmacokinetics of vitamin K antagonists: warfarin, phenprocoumon and acenocoumarol. Clin Pharmacokinet. 2005;44(12):1227-46.
179 Characterization of human cytochrome P450 enzymes involved in the metabolism of cyamemazine. Eur J Pharm Sci. 2007 Dec;32(4-5):357-66.