Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMHWE7P)

Drug Name

Ampicillin Drug Info

Synonyms

ABPC; Acillin; Adobacillin; Alpen; Amblosin; Amcill; Amfipen; Aminobenzylpenicillin; Ampen; Ampichel; Ampicil; Ampicilina; Ampicillanyl; Ampicillina; Ampicilline; Ampicillinum; Ampicin; Ampifarm; Ampikel; Ampimed; Ampipenin; Ampiscel; Ampisyn; Ampivax; Ampivet; Amplacilina; Amplin; Amplipenyl; Amplisom; Amplital; Austrapen; Binotal; Bonapicillin; Britacil; Campicillin; Cimex; Copharcilin; Delcillin; Deripen; Divercillin; Doktacillin; Duphacillin; Grampenil; Guicitrina; Guicitrine; Lifeampil; Morepen; Norobrittin; Nuvapen; Omnipen; Orbicilina; Penbristol; Penbritin; Penbrock; Penicline; Penimic; Pensyn; Pentrex; Pentrexl; Pentrexyl; Polycillin; Ponecil; Princillin; Principen; QIDamp; Racenacillin; Rosampline;Roscillin; Semicillin; Servicillin; Sumipanto; Supen; Synpenin; Texcillin; Tokiocillin; Tolomol; Totacillin; Totalciclina; Totapen; Trifacilina; Ukapen; Ultrabion; Ultrabron; Vampen; Viccillin; Wypicil; Amfipen V; Amipenix S; Ampicillin A; Ampicillin Anhydrous; Ampicillin Base; Ampicillin acid; Ampicillin anhydrate; Ampicillina [DCIT]; Anhydrous ampicillin; Olin Kid; Pen A; Pen A Oral; Pen Ampil;Penbritin paediatric; Penbritin syrup; Pfizerpen A; Semicillin R; Viccillin S; AY 6108; BA 7305; BRL 1341; Bayer 5427; HI 63; P 50; Principen 125; Principen 250; Principen 500; SQ 17382; AB-PC; AB-PCSol; AY-6108; Ambidrin (TN); Ampi-Co; Ampi-Tab; Ampi-bol; Ampicilina [INN-Spanish]; Ampicilline [INN-French]; Ampicillinum [INN-Latin]; Ampipenin, nt3; Ampy-Penyl; Anhydrous ampicillin (JP15); BRL-1341; D-Ampicillin; D-Cillin; KS-R1; Novo-ampicillin; OMNIPEN (AMPICILLIN); Omnipen (TN); Omnipen-N; P-50; Penbritin-S; Penicillin, Aminobenzyl; Pfizerpen-A; Polycillin-N; Polyflex (Veterinary); Ro-Ampen; SK-Ampicillin; Totacillin (sodium); Totacillin-N; WY-5103; Ampicillin (USP/INN); AMPICILLIN (SEE ALSO AMPICILLIN TRIHYDRATE 7177-48-2); Ampicillin [USAN:BAN:INN:JAN]; Ampicillin [USAN:INN:BAN:JAN];D-(-)-Ampicillin; D-(-)-alpha-Aminobenzylpenicillin; D-(-)-alpha-Aminopenicillin; D-(-)-6-(alpha-Aminophenylacetamido)penicillanic acid; 6-(D(-)-alpha-Aminophenylacetamido)penicillanic acid; 6beta-[(2R)-2-amino-2-phenylacetamido]-2,2-dimethylpenam-3alpha-carbonyl; 6beta-[(2R)-2-amino-2-phenylacetamido]-2,2-dimethylpenam-3alpha-carboxylic acid

Indication

Disease Entry	ICD 11	Status	REF
Bacterial infection	1A00-1C4Z	Approved	[1]

Therapeutic Class

Antibiotics

Cross-matching ID

PubChem CID: 6249
ChEBI ID: CHEBI:28971
CAS Number: CAS 69-53-4
TTD Drug ID: DMHWE7P
VARIDT Drug ID: DR00712
INTEDE Drug ID: DR2177
ACDINA Drug ID: D00037

Molecule-Related Drug Atlas

Molecule Type:

DTT

DTP

DME

Drug Status:

Approved Drug(s)

Clinical Trial Drug(s)

Discontinued Drug(s)

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Drug(s) Metabolized By N-acylhomoserine lactone acylase (lacA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Bacterial infection	1A00-1C4Z	Approved	[6]
Cefadroxil	DMMC345	Bacterial infection	1A00-1C4Z	Approved	[6]
Cephalexin	DMD5JU8	Bacterial infection	1A00-1C4Z	Approved	[6]
Carbenicillin	DMLEDNK	Infection of the upper and lower urinary tract	GC08	Approved	[6]
Benzylpenicillin	DMS9503	N. A.	N. A.	Phase 3	[6]
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Drug(s) Metabolized By Beta-lactamase (blaB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Bacterial infection	1A00-1C4Z	Approved	[12]
Piperacillin	DMTBKF3	Bacterial infection	1A00-1C4Z	Approved	[7]
Cefalotin	DMVYSLE	Bacterial infection	1A00-1C4Z	Approved	[7]
Benzylpenicillin	DMS9503	N. A.	N. A.	Phase 3	[7]
Cephaloridine	DM4Y95F	Gram-positive bacterial infection	1B74-1G40	Withdrawn from market	[7]
Ceftiofur	DMR2SOZ	Bacterial infection	1A00-1C4Z	Approved	[13]
Amoxicillin	DMUYNEI	Bacterial infection	1A00-1C4Z	Approved	[14]
Benzylpenicillin	DMS9503	N. A.	N. A.	Phase 3	[15]
Amoxicillin	DMUYNEI	Bacterial infection	1A00-1C4Z	Approved	[14]
Carbenicillin	DMLEDNK	Infection of the upper and lower urinary tract	GC08	Approved	[11]
Imipenem	DMI9FBP	Bacterial infection	1A00-1C4Z	Approved	[16]
Ceftriaxone	DMCEW64	Bacterial infection	1A00-1C4Z	Approved	[9]
Meropenem	DM62UHC	Bacterial infection	1A00-1C4Z	Approved	[16]
Carbapenem	DMXZU73	Cystitis	GC00	Phase 4	[17]
Ceftazidine	DMPZTRC	Meningitis	1D01	Phase 4	[9]
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Drug(s) Metabolized By AmpC beta-lactamase (ampC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Imipenem	DMI9FBP	Bacterial infection	1A00-1C4Z	Approved	[10]
Cefalotin	DMVYSLE	Bacterial infection	1A00-1C4Z	Approved	[10]
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Drug(s) Transported By Multidrug resistance-associated protein 2 (ABCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Solid tumour/cancer	2A00-2F9Z	Approved	[18]
Methotrexate	DM2TEOL	leukaemia	2A60-2B33	Approved	[19]
Folic acid	DMEMBJC	Folate-deficiency anemia	3A02.Y	Approved	[20]
Fluorouracil	DMUM7HZ	Solid tumour/cancer	2A00-2F9Z	Approved	[21]
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[22]
Cisplatin	DMRHGI9	Solid tumour/cancer	2A00-2F9Z	Approved	[23]
Acetaminophen	DMUIE76	Pain	MG30-MG3Z	Approved	[24]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[25]
Etoposide	DMNH3PG	Solid tumour/cancer	2A00-2F9Z	Approved	[26]
Oxaliplatin	DMQNWRD	Colorectal cancer	2B91.Z	Approved	[27]
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Drug(s) Transported By Peptide transporter 1 (SLC15A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Bacterial infection	1A00-1C4Z	Approved	[28]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[29]
Losartan	DM72JXH	Hypertension	BA00-BA04	Approved	[30]
Enalapril	DMNFUZR	Hypertension	BA00-BA04	Approved	[31]
Cefazolin	DMPDYFR	Bacterial infection	1A00-1C4Z	Approved	[32]
Ceftriaxone	DMCEW64	Bacterial infection	1A00-1C4Z	Approved	[33]
Dexamethasone	DMMWZET	Rheumatoid arthritis	FA20	Approved	[29]
Cefadroxil	DMMC345	Bacterial infection	1A00-1C4Z	Approved	[30]
Irbesartan	DMTP1DC	Hypertension	BA00-BA04	Approved	[30]
Valsartan	DMREUQ6	Hypertension	BA00-BA04	Approved	[30]
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Drug(s) Transported By Peptide transporter 2 (SLC15A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Bacterial infection	1A00-1C4Z	Approved	[28]
Enalapril	DMNFUZR	Hypertension	BA00-BA04	Approved	[34]
Entecavir	DM7VTQO	Hepatitis B virus infection	1E51.0	Approved	[35]
Cefadroxil	DMMC345	Bacterial infection	1A00-1C4Z	Approved	[36]
Cephalexin	DMD5JU8	Bacterial infection	1A00-1C4Z	Approved	[3]
Valaciclovir	DMHKS94	Virus infection	1A24-1D9Z	Approved	[37]
Cefaclor	DMJXDGC	Bacterial infection	1A00-1C4Z	Approved	[28]
Aminolevulinic acid hci	DMS4BLQ	Acne vulgaris	ED80	Approved	[38]
Spirapril	DM5XLTY	Hypertension	BA00-BA04	Approved	[39]
Cefixime	DMY60I8	Bacterial infection	1A00-1C4Z	Approved	[3]
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Drug(s) Targeting Bacterial Penicillin binding protein (Bact PBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cefazolin	DMPDYFR	Bacterial infection	1A00-1C4Z	Approved	[40]
Ceftriaxone	DMCEW64	Bacterial infection	1A00-1C4Z	Approved	[41]
Ticarcillin	DM4ME02	Bacterial infection	1A00-1C4Z	Approved	[42]
Ciprofloxacin XR	DM2NLS9	Bacterial infection	1A00-1C4Z	Approved	[43]
Meropenem	DM62UHC	Bacterial infection	1A00-1C4Z	Approved	[41]
Cefadroxil	DMMC345	Bacterial infection	1A00-1C4Z	Approved	[44]
Clofarabine	DMCVJ86	Acute lymphoblastic leukaemia	2A85	Approved	[45]
Cephalexin	DMD5JU8	Bacterial infection	1A00-1C4Z	Approved	[46]
Carbenicillin	DMLEDNK	Infection of the upper and lower urinary tract	GC08	Approved	[47]
Piperacillin	DMTBKF3	Bacterial infection	1A00-1C4Z	Approved	[48]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas

Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bacterial Penicillin binding protein (Bact PBP)	TTJP4SM	NOUNIPROTAC	Binder	[2]

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Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Peptide transporter 2 (SLC15A2)	DT8QKNP	S15A2_HUMAN	Substrate	[3]
Peptide transporter 1 (SLC15A1)	DT9G7XN	S15A1_HUMAN	Substrate	[4]
Multidrug resistance-associated protein 2 (ABCC2)	DTFI42L	MRP2_HUMAN	Substrate	[5]

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Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
N-acylhomoserine lactone acylase (lacA)	DEIU0XN	A0A0A1VBK6_9BURK	Substrate	[6]
Beta-lactamase (blaB)	DET9I1W	BLAC_BACUN	Substrate	[7]
Beta-lactamase (blaB)	DETDS7E	A0A2S0LB67_9FLAO	Substrate	[8]
Beta-lactamase (blaB)	DEC7JEF	A0A1S1G219_9NEIS	Substrate	[8]
Beta-lactamase (blaB)	DEBKS91	A0A1B1FBM9_ACIBA	Substrate	[9]
AmpC beta-lactamase (ampC)	DERI7LO	A0A0H3KQ39_BURM1	Substrate	[10]
Beta-lactamase (blaB)	DEWYT5M	D4HFC4_CUTAS	Substrate	[8]
Beta-lactamase (blaB)	DE3FVRW	BLA2_BAC17	Substrate	[8]
Beta-lactamase (blaB)	DEG5Y4W	A0A344X3A2_STASP	Substrate	[8]
Beta-lactamase (blaB)	DEQX0DG	Q8RIK5_FUSNN	Substrate	[8]
Beta-lactamase (blaB)	DEXB2A9	A0A379CPC3_PLESH	Substrate	[11]
Beta-lactamase (blaB)	DEWMGC3	A0A2U9SV73_9BURK	Substrate	[8]
Beta-lactamase (blaB)	DE52KD0	Q6EZ46_RALPI	Substrate	[8]

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References

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