Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMNLQHK)

Drug Name
Tanespimycin Drug Info
Synonyms
CNF-101; [(3S,5S,6R,7S,8E,10R,11S,12E,14E)-6-Hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-21-(prop-2-enylamino)-17-azabicyclo[16.3.1]docosa-8,12,14,18,21-pentaen-10-yl] carbamate; [(3R,5S,6R,7S,8E,10S,11S,12Z,14E)-6-hydroxy-5,11-dimethoxy-3,7,9,15-tetramethyl-16,20,22-trioxo-21-(prop-2-enylamino)-17-azabicyclo[16.3.1]docosa-1(21),8,12,14,18-pentaen-10-yl] carbamate; 17AAG, Tanespimycin, Geldanamycin, NSC330507, 17-(Allylamino)-17-demethoxygeldanamycin, CP 127374
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Phase 2 [1]
Multiple myeloma 2A83 Discontinued in Phase 3 [1]
Therapeutic Class
Anticancer Agents
Cross-matching ID
PubChem CID
6505803
ChEBI ID
CHEBI:64153
CAS Number
CAS 75747-14-7
TTD Drug ID
DMNLQHK

Molecule-Related Drug Atlas

Molecule-Related Drug Atlas
Molecule Type:
DTT
DOT
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Patented Agent(s)
Preclinical Drug(s)
Download the Complete Related Drug List
Drug(s) Targeting Heat shock protein 90 alpha (HSP90A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cromoglicate DM74LZK Asthma CA23 Approved [10]
Amlexanox DM0DQM5 Respiratory tract inflammation CA07 Approved [10]
NVP-AUY922 DMTYXQF Multiple myeloma 2A83 Phase 2 [11]
BIIB-021 DMPAJ41 Breast cancer 2C60-2C65 Phase 2 [12]
KW-2478 DMJGL72 Solid tumour/cancer 2A00-2F9Z Phase 2 [13]
VER 50589 DMFLZPC Breast cancer 2C60-2C65 Phase 2 [11]
Efungumab DMBHP56 Breast cancer 2C60-2C65 Phase 2 [14]
SNX-5422 DMIU0VP Haematological malignancy 2B33.Y Phase 1/2 [15]
PU3 DMJO0BP Solid tumour/cancer 2A00-2F9Z Phase 1 [11]
Debio 0932 DMWP3G1 Solid tumour/cancer 2A00-2F9Z Phase 1 [16]
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Drug(s) Affected By Androgen receptor (AR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [17]
Nilutamide DMFN07X Prostate cancer 2C82.0 Approved [17]
Hydroxyflutamide DMGIZF5 Prostate cancer 2C82.0 Approved [17]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [18]
Bicalutamide DMZMSPF Prostate cancer 2C82.0 Approved [19]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [20]
Drospirenone DM1A9W3 Acne vulgaris ED80 Approved [21]
Nitrendipine DM21C09 Hypertension BA00-BA04 Approved [22]
Selenium DM25CGV N. A. N. A. Approved [23]
Spironolactone DM2AQ5N Chronic heart failure BD1Z Approved [24]
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Drug(s) Affected By Receptor-type tyrosine-protein kinase FLT3 (FLT3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quizartinib DM8Y4JS Acute myeloid leukaemia 2A60 Approved [25]
Midostaurin DMI6E0R Acute myeloid leukaemia 2A60 Approved [26]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [27]
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [28]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [30]
Venetoclax DM8I94Y Chronic lymphocytic leukaemia 2A82.0 Approved [31]
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [32]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [33]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [34]
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Drug(s) Affected By Apoptotic protease-activating factor 1 (APAF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [35]
Methotrexate DM2TEOL Anterior urethra cancer Approved [36]
Quercetin DM3NC4M Obesity 5B81 Approved [37]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [38]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [39]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [40]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [41]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [42]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [43]
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Drug(s) Affected By Protein MTSS 1 (MTSS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [44]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [45]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [46]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [47]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [48]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [49]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [50]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [51]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [52]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [53]
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Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [54]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [55]
Quercetin DM3NC4M Obesity 5B81 Approved [56]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Remdesivir DMBFZ6L Coronavirus Disease 2019 (COVID-19) 1D6Y Approved [57]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [58]
Panobinostat DM58WKG Chronic graft versus host disease Approved [59]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [60]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [61]
Testosterone DM7HUNW Hot flushes GA30 Approved [62]
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Drug(s) Affected By Anterior gradient protein 2 homolog (AGR2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [63]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [64]
Quercetin DM3NC4M Obesity 5B81 Approved [44]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [65]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [66]
Prasterone DM67VKL Chronic obstructive pulmonary disease CA22 Approved [67]
Testosterone DM7HUNW Hot flushes GA30 Approved [68]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [68]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [46]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [43]
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Drug(s) Affected By Epidermal growth factor receptor (EGFR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
BIBW 2992 DMTKD7Q Non-small-cell lung cancer 2C25.Y Approved [69]
Gefitinib DM15F0X Colon adenocarcinoma Approved [70]
Erlotinib DMCMBHA Adrenal gland neoplasm Approved [71]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [72]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [73]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [74]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [75]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [76]
Selenium DM25CGV N. A. N. A. Approved [77]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [78]
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Drug(s) Affected By RAF proto-oncogene serine/threonine-protein kinase (RAF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [79]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [80]
Quercetin DM3NC4M Obesity 5B81 Approved [81]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [82]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [83]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [40]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [84]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [85]
Testosterone DM7HUNW Hot flushes GA30 Approved [86]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [87]
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Drug(s) Affected By Annexin A1 (ANXA1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [88]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [89]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [90]
Panobinostat DM58WKG Chronic graft versus host disease Approved [59]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [66]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [91]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [92]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [93]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [89]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [46]
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Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Trastuzumab DMZQOUX Breast cancer 2C60-2C65 Approved [94]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [79]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [95]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [96]
Gefitinib DM15F0X Colon adenocarcinoma Approved [97]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [98]
Selenium DM25CGV N. A. N. A. Approved [99]
Methotrexate DM2TEOL Anterior urethra cancer Approved [36]
Quercetin DM3NC4M Obesity 5B81 Approved [100]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [101]
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Drug(s) Affected By Cellular tumor antigen p53 (TP53)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [102]
Methotrexate DM2TEOL Anterior urethra cancer Approved [103]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [104]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [105]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [106]
Paclitaxel DMLB81S Breast carcinoma Approved [107]
Floxuridine DM04LR2 Colorectal cancer 2B91.Z Approved [108]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [109]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [110]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [111]
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Drug(s) Affected By Retinoblastoma-associated protein (RB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [112]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [113]
Gefitinib DM15F0X Colon adenocarcinoma Approved [114]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [115]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [98]
Trametinib DM2JGQ3 Melanoma 2C30 Approved [55]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [116]
Methotrexate DM2TEOL Anterior urethra cancer Approved [117]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [118]
Quercetin DM3NC4M Obesity 5B81 Approved [100]
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Drug(s) Affected By Cyclin-dependent kinase 1 (CDK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [119]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [120]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [121]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [64]
Selenium DM25CGV N. A. N. A. Approved [122]
Etretinate DM2CZFA Keratosis ED56 Approved [123]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [124]
Methotrexate DM2TEOL Anterior urethra cancer Approved [36]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [125]
Quercetin DM3NC4M Obesity 5B81 Approved [100]
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Drug(s) Affected By ATP synthase subunit beta, mitochondrial (ATP5F1B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [126]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [64]
Etretinate DM2CZFA Keratosis ED56 Approved [127]
Quercetin DM3NC4M Obesity 5B81 Approved [128]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [129]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [46]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [130]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [43]
Ethanol DMDRQZU Chronic pain MG30 Approved [131]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [129]
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Drug(s) Affected By Alpha-enolase (ENO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [132]
Etretinate DM2CZFA Keratosis ED56 Approved [127]
Methotrexate DM2TEOL Anterior urethra cancer Approved [133]
Quercetin DM3NC4M Obesity 5B81 Approved [134]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [135]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [101]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [136]
Liothyronine DM6IR3P Congenital hypothyroidism Approved [137]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [138]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [139]
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Drug(s) Affected By L-lactate dehydrogenase B chain (LDHB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [64]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [48]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [140]
Ibuprofen DM8VCBE Dysmenorrhea GA34.3 Approved [141]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [142]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [143]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [47]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [43]
Fenofibrate DMFKXDY Coronary atherosclerosis Approved [48]
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Drug(s) Affected By Profilin-1 (PFN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [144]
Selenium DM25CGV N. A. N. A. Approved [99]
Etretinate DM2CZFA Keratosis ED56 Approved [127]
Quercetin DM3NC4M Obesity 5B81 Approved [145]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [146]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [147]
Acocantherin DM7JT24 Atrial fibrillation BC81.3 Approved [148]
Haloperidol DM96SE0 Delirium Approved [149]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [143]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [43]
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Drug(s) Affected By Insulin-like growth factor 1 receptor (IGF1R)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [150]
Gefitinib DM15F0X Colon adenocarcinoma Approved [151]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [152]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [153]
Quercetin DM3NC4M Obesity 5B81 Approved [154]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [155]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [156]
Testosterone DM7HUNW Hot flushes GA30 Approved [68]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [68]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [139]
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Drug(s) Affected By Heat shock protein HSP 90-beta (HSP90AB1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [157]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [158]
Selenium DM25CGV N. A. N. A. Approved [99]
Etretinate DM2CZFA Keratosis ED56 Approved [127]
Quercetin DM3NC4M Obesity 5B81 Approved [159]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [160]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [161]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [136]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [83]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [46]
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Drug(s) Affected By Hepatocyte growth factor receptor (MET)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cabozantinib DMIYDT4 Medullary thyroid gland carcinoma Approved [162]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [58]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [163]
Lumiracoxib DM1S4AG Chronic renal failure GB61.Z Approved [163]
Clavulanate DM2FGRT Bacteremia 1A73 Approved [163]
Methotrexate DM2TEOL Anterior urethra cancer Approved [164]
Quercetin DM3NC4M Obesity 5B81 Approved [44]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [163]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [165]
Methylprednisolone DM4BDON Acute adrenal insufficiency Approved [164]
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Drug(s) Affected By Platelet-derived growth factor receptor beta (PDGFRB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [64]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [166]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [65]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [167]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [168]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [169]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [47]
Folic Acid DMEMBJC Colorectal carcinoma Approved [170]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [171]
Dasatinib DMJV2EK Blast phase chronic myelogenous leukemia, BCR-ABL1 positive Approved [172]
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Drug(s) Affected By Poly polymerase 1 (PARP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [173]
Gefitinib DM15F0X Colon adenocarcinoma Approved [174]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [175]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [176]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [177]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [178]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [177]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [179]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [180]
Methotrexate DM2TEOL Anterior urethra cancer Approved [181]
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Drug(s) Affected By Heat shock 70 kDa protein 1A (HSPA1A)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [182]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [183]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [75]
Gefitinib DM15F0X Colon adenocarcinoma Approved [184]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [185]
Selenium DM25CGV N. A. N. A. Approved [99]
Etretinate DM2CZFA Keratosis ED56 Approved [127]
Methotrexate DM2TEOL Anterior urethra cancer Approved [103]
Quercetin DM3NC4M Obesity 5B81 Approved [44]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [160]
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Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [186]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [187]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [188]
Gemcitabine DMSE3I7 Anterior urethra cancer Approved [189]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [94]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [173]
Verapamil DMA7PEW Angina pectoris BA40 Approved [190]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [191]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [192]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [193]
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Drug(s) Affected By Mast/stem cell growth factor receptor Kit (KIT)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [194]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [195]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [27]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [166]
Panobinostat DM58WKG Chronic graft versus host disease Approved [59]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [196]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [197]
Ethanol DMDRQZU Chronic pain MG30 Approved [198]
Cholecalciferol DMGU74E Adult acute monocytic leukemia Approved [199]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [200]
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Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [157]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [201]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [202]
Etretinate DM2CZFA Keratosis ED56 Approved [127]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [203]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [204]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [205]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [206]
Quercetin DM3NC4M Obesity 5B81 Approved [44]
Furazolidone DM3P6V7 Diarrhea ME05.1 Approved [207]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Palbociclib DMD7L94 Breast cancer 2C60-2C65 Approved [208]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [209]
Selenium DM25CGV N. A. N. A. Approved [122]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [210]
Methotrexate DM2TEOL Anterior urethra cancer Approved [36]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [211]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [212]
Quercetin DM3NC4M Obesity 5B81 Approved [100]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [213]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Elongation factor 2 (EEF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [140]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [214]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [47]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [43]
Paclitaxel DMLB81S Breast carcinoma Approved [215]
Arsenic DMTL2Y1 N. A. N. A. Approved [216]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [217]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [218]
Cytarabine DMZD5QR Acute lymphoblastic leukaemia 2A85 Approved [219]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [218]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Plastin-2 (LCP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [66]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [169]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [47]
Hydroxyflutamide DMGIZF5 Prostate cancer 2C82.0 Approved [220]
Enzalutamide DMGL19D Prostate cancer 2C82.0 Approved [221]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [200]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [49]
Arsenic DMTL2Y1 N. A. N. A. Approved [222]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [223]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Macrophage migration inhibitory factor (MIF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [224]
Quercetin DM3NC4M Obesity 5B81 Approved [225]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [146]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [140]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [226]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [43]
Folic Acid DMEMBJC Colorectal carcinoma Approved [227]
Benzatropine DMF7EXL Parkinsonian disorder Approved [149]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [49]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [50]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Pyruvate kinase PKM (PKM)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [144]
Selenium DM25CGV N. A. N. A. Approved [99]
Epinephrine DM3KJBC Acute asthma CA23 Approved [228]
Quercetin DM3NC4M Obesity 5B81 Approved [44]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [229]
Panobinostat DM58WKG Chronic graft versus host disease Approved [59]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [230]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [231]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [214]
Dihydroartemisinin DMBXVMZ Malaria 1F40-1F45 Approved [143]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine/threonine-protein kinase B-raf (BRAF)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [232]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [65]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [167]
Leflunomide DMR8ONJ Arthritis FA20 Approved [233]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [169]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [234]
Niclosamide DMJAGXQ Cestodes infection 1F70-1F76 Approved [235]
Diclofenac DMPIHLS Chronic renal failure GB61.Z Approved [236]
Famotidine DMRL3AB Gastric ulcer DA60 Approved [237]
Sorafenib DMS8IFC Adenocarcinoma 2D40 Approved [238]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Intron Large complex component GCFC2 (GCFC2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [44]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [169]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [43]
Arsenic DMTL2Y1 N. A. N. A. Approved [222]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [239]
Dihydrotestosterone DM3S8XC Prostate hyperplasia GA90 Phase 4 [221]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [99]
NVP-AUY922 DMTYXQF Multiple myeloma 2A83 Phase 2 [3]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [240]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By CCAAT/enhancer-binding protein beta (CEBPB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [173]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [64]
Methotrexate DM2TEOL Anterior urethra cancer Approved [241]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [242]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [243]
Quercetin DM3NC4M Obesity 5B81 Approved [244]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [213]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [161]
Cyclophosphamide DM4O2Z7 Advanced cancer 2A00-2F9Z Approved [245]
Panobinostat DM58WKG Chronic graft versus host disease Approved [59]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Liver carboxylesterase 1 (CES1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [246]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [195]
Dextropropoxyphene DM23HCX Pain MG30-MG3Z Approved [247]
Selenium DM25CGV N. A. N. A. Approved [99]
Naloxone DM3FXMA Narcotic depression 6A7Z Approved [248]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Tacrine DM51FY6 Alzheimer disease 8A20 Approved [249]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [250]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [91]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [214]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Indomethacin DMSC4A7 Bursitis Approved [251]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [252]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [193]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [253]
Gefitinib DM15F0X Colon adenocarcinoma Approved [70]
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [115]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [254]
Selenium DM25CGV N. A. N. A. Approved [99]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [255]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [256]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fructose DM43AN2 Vomiting MD90 Approved [94]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [257]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [35]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [258]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [259]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [260]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [261]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [262]
Deoxycholic acid DM3GYAL Subcutaneous fat disorder EF02 Approved [263]
Quercetin DM3NC4M Obesity 5B81 Approved [44]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Moesin (MSN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [99]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [264]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [46]
Testosterone enanthate DMB6871 N. A. N. A. Approved [265]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [47]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [43]
Rosiglitazone DMILWZR Chronic kidney disease GB61 Approved [266]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [267]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [52]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [217]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Elongation factor 1-gamma (EEF1G)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Etretinate DM2CZFA Keratosis ED56 Approved [127]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [146]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [229]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [43]
Menthol DMG2KW7 Back pain ME84.Z Approved [268]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [49]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [269]
Arsenic DMTL2Y1 N. A. N. A. Approved [222]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [270]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [217]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [271]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [272]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [273]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [192]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [274]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [275]
Secobarbital DM14RF5 Epilepsy 8A60-8A68 Approved [276]
Gefitinib DM15F0X Colon adenocarcinoma Approved [277]
Fexofenadine DM17ONX Allergic rhinitis CA08.0 Approved [278]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [279]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ethanol DMDRQZU Chronic pain MG30 Approved [280]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [272]
Carvedilol DMHTEAO Chronic heart failure BD1Z Approved [281]
Paclitaxel DMLB81S Breast carcinoma Approved [282]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [283]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [271]
Urokinase DM0GOUD Myocardial infarction BA41-BA43 Approved [94]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [35]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [192]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [274]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By M-phase inducer phosphatase 3 (CDC25C)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [119]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [98]
Methotrexate DM2TEOL Anterior urethra cancer Approved [36]
Quercetin DM3NC4M Obesity 5B81 Approved [44]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [213]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [136]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [284]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [285]
Testosterone DM7HUNW Hot flushes GA30 Approved [68]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [286]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [287]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [109]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [193]
Gefitinib DM15F0X Colon adenocarcinoma Approved [288]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [289]
Imiquimod DM1TMA3 Alopecia areata ED70.2 Approved [290]
Selenium DM25CGV N. A. N. A. Approved [99]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [152]
Ribavirin DMEYLH9 Hepatitis C virus infection 1E51.1 Approved [255]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serine hydroxymethyltransferase, mitochondrial (SHMT2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [138]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [46]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [234]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [43]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [291]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [50]
Dopamine DMPGUCF Acromegaly 5A60.0 Approved [292]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [293]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [223]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heat shock 70 kDa protein 4 (HSPA4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [294]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [157]
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [158]
Methotrexate DM2TEOL Anterior urethra cancer Approved [103]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [295]
Quercetin DM3NC4M Obesity 5B81 Approved [44]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [160]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [136]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [46]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Radixin (RDX)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Haloperidol DM96SE0 Delirium Approved [149]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [46]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [43]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [50]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [296]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [293]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [297]
Fluorouracil DMUM7HZ Adenocarcinoma 2D40 Approved [298]
Topotecan DMP6G8T Central nervous system neoplasm Approved [299]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Metalloproteinase inhibitor 3 (TIMP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Selenium DM25CGV N. A. N. A. Approved [77]
Pentosan Polysulfate DM2HRKE Interstitial cystitis GC00.3 Approved [300]
Methotrexate DM2TEOL Anterior urethra cancer Approved [36]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [301]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [101]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [65]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [60]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [45]
Leflunomide DMR8ONJ Arthritis FA20 Approved [233]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [46]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Aryl hydrocarbon receptor (AHR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [302]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [303]
Citalopram DM2G9AE Acute coronary syndrome BA41 Approved [304]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [305]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [306]
Quercetin DM3NC4M Obesity 5B81 Approved [307]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [308]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [166]
Rifampicin DM5DSFZ Non-insulin dependent diabetes 5A11 Approved [309]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [310]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Vascular endothelial growth factor receptor 2 (KDR)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Romiplostim DM3U7SZ Thrombocytopenia 3B64 Approved [28]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [101]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [311]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [312]
Haloperidol DM96SE0 Delirium Approved [149]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [46]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [234]
Clozapine DMFC71L Schizophrenia 6A20 Approved [149]
Menthol DMG2KW7 Back pain ME84.Z Approved [268]
Orlistat DMRJSP8 Obesity 5B81 Approved [313]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Serpin B5 (SERPINB5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [185]
Methotrexate DM2TEOL Anterior urethra cancer Approved [36]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [314]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [315]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [139]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [47]
2-deoxyglucose DMIAHVU Solid tumour/cancer 2A00-2F9Z Approved [316]
Adefovir Dipivoxil DMMAWY1 Hepatitis B virus infection 1E51.0 Approved [139]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [317]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [318]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-3 (CASP3)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [319]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [320]
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [321]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [106]
Docetaxel DMDI269 Advanced cancer 2A00-2F9Z Approved [322]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [323]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [324]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [325]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [326]
Aprepitant DM053KT Depression 6A70-6A7Z Approved [257]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Cyclin-dependent kinase 8 (CDK8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [100]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [161]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [234]
Progesterone DMUY35B Amenorrhea GA20.0 Approved [327]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [217]
DTI-015 DMXZRW0 Brain cancer 2A00 Approved [328]
Urethane DM7NSI0 N. A. N. A. Phase 4 [329]
Tamibarotene DM3G74J T-cell leukaemia 2A90 Phase 3 [161]
Resveratrol DM3RWXL Giant cell arteritis 4A44.2 Phase 3 [330]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [331]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [157]
Gefitinib DM15F0X Colon adenocarcinoma Approved [114]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [332]
Selenium DM25CGV N. A. N. A. Approved [99]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [333]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [334]
Quercetin DM3NC4M Obesity 5B81 Approved [335]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [336]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [337]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Transcription initiation factor IIA subunit 2 (GTF2A2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [338]
Testosterone DM7HUNW Hot flushes GA30 Approved [62]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [47]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [43]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [217]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [240]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [339]
Milchsaure DM462BT Pruritus EC90 Investigative [340]
Formaldehyde DM7Q6M0 Discovery agent N.A. Investigative [341]
chloropicrin DMSGBQA Discovery agent N.A. Investigative [342]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-9 (CASP9)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [343]
Mannitol DMSCDY9 Bronchiectasis CA24 Approved [344]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [173]
Mechlorethamine DM0CVXA Chronic myelogenous leukaemia 2A20.0 Approved [191]
Leuprorelin acetate DM15HAT Prostate cancer 2C82.0 Approved [345]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [346]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [176]
Meloxicam DM2AR7L Arthritis FA20 Approved [347]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [348]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [349]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Small ribosomal subunit protein eS6 (RPS6)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [350]
Methotrexate DM2TEOL Anterior urethra cancer Approved [241]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [351]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [352]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [264]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [353]
Testosterone DM7HUNW Hot flushes GA30 Approved [354]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [355]
Capivasertib DM9SKW8 Breast cancer 2C60-2C65 Approved [286]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [46]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Heat shock factor protein 1 (HSF1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [356]
SPI-1005 DM6XFHS Reperfusion injury ND56.Z Approved [357]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [357]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [358]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [295]
Ceftazidime DM41GRA Bacteremia 1A73 Approved [357]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Chlorpheniramine DM5URA2 Allergic rhinitis CA08.0 Approved [357]
Ethacrynic acid DM60QMR Edema MG29 Approved [357]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [357]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By E3 ubiquitin-protein ligase Mdm2 (MDM2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [35]
Flucytosine DM13VTW Cryptococcal meningitis Approved [359]
Ganciclovir DM1MBYQ Cytomegalovirus infection 1D82 Approved [359]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [360]
Methotrexate DM2TEOL Anterior urethra cancer Approved [36]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [361]
Quercetin DM3NC4M Obesity 5B81 Approved [44]
Zidovudine DM4KI7O Human immunodeficiency virus infection 1C62 Approved [104]
Acetic Acid, Glacial DM4SJ5Y infection in the ear canal AA0Y Approved [136]
Amifostine DM5FL14 Mucositis CA00 Approved [362]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Runt-related transcription factor 1 (RUNX1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [27]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [213]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [161]
Testosterone DM7HUNW Hot flushes GA30 Approved [68]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [45]
Leflunomide DMR8ONJ Arthritis FA20 Approved [233]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [139]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [139]
Cotinine DMCEZ1B Insecticide N.A. Approved [363]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [47]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Echinoderm microtubule-associated protein-like 5 (EML5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [142]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [364]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [63]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [365]
NVP-AUY922 DMTYXQF Multiple myeloma 2A83 Phase 2 [3]
PMID28460551-Compound-2 DM4DOUB N. A. N. A. Patented [366]
COUMARIN DM0N8ZM Discovery agent N.A. Investigative [367]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [339]
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Drug(s) Affected By Protein CBFA2T1 (RUNX1T1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Panobinostat DM58WKG Chronic graft versus host disease Approved [59]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [142]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [234]
Melphalan DMOLNHF Hematologic disease 3C0Z Approved [368]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [217]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [239]
Nicotine DMWX5CO Lung cancer 2C25.0 Approved [369]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [59]
PDX-101 DM6OC53 Plasma cell myeloma 2A83.1 Phase 2 [59]
Tocopherol DMBIJZ6 N. A. N. A. Phase 2 [99]
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Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [109]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [370]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [176]
Selenium DM25CGV N. A. N. A. Approved [99]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [371]
Methotrexate DM2TEOL Anterior urethra cancer Approved [36]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [359]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [372]
Quercetin DM3NC4M Obesity 5B81 Approved [335]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [160]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [192]
Beta-carotene DM0RXBT Vitamin deficiency 5B55-5B71 Approved [373]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [374]
Methotrexate DM2TEOL Anterior urethra cancer Approved [375]
Dactinomycin DM2YGNW Adult kidney Wilms tumor Approved [376]
Quercetin DM3NC4M Obesity 5B81 Approved [154]
Penicillamine DM40EF6 Cystinuria 5C60.2 Approved [377]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [373]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [378]
Ethacrynic acid DM60QMR Edema MG29 Approved [379]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Dehydrogenase/reductase SDR family member 2, mitochondrial (DHRS2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [64]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [101]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [380]
Testosterone DM7HUNW Hot flushes GA30 Approved [68]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [68]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [46]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [234]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [381]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [49]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [382]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Eukaryotic translation initiation factor 3 subunit I (EIF3I)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [140]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [138]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [46]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [234]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [43]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [50]
NVP-AUY922 DMTYXQF Multiple myeloma 2A83 Phase 2 [3]
TAK-243 DM4GKV2 Solid tumour/cancer 2A00-2F9Z Phase 1 [383]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [240]
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Drug(s) Affected By Src substrate cortactin (CTTN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [384]
Quercetin DM3NC4M Obesity 5B81 Approved [44]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Isotretinoin DM4QTBN Acne vulgaris ED80 Approved [65]
Clodronate DM9Y6X7 Hypercalcaemia 5B91.0 Approved [139]
Cidofovir DMA13GD Cytomegalovirus infection 1D82 Approved [139]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [169]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [47]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [139]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [43]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By Caspase-8 (CASP8)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Lovastatin DM9OZWQ Arteriosclerosis BD40 Approved [385]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [386]
Etoposide DMNH3PG Acute myelogenous leukaemia 2A41 Approved [387]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [35]
Gefitinib DM15F0X Colon adenocarcinoma Approved [388]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [389]
Nitric Oxide DM1RBYG Hypertension BA00-BA04 Approved [176]
Selenium DM25CGV N. A. N. A. Approved [99]
Ciprofloxacin XR DM2NLS9 Acute gonococcal cervicitis Approved [348]
Methotrexate DM2TEOL Anterior urethra cancer Approved [103]
⏷ Show the Full List of 10 Drug(s)
Drug(s) Affected By La-related protein 7 (LARP7)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [101]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [47]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [43]
Ethanol DMDRQZU Chronic pain MG30 Approved [390]
Clozapine DMFC71L Schizophrenia 6A20 Approved [149]
Decitabine DMQL8XJ Acute myelogenous leukaemia 2A41 Approved [296]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [52]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [217]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [239]
Carbamazepine DMZOLBI Epilepsy 8A60-8A68 Approved [226]
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Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase TPTE2 (TPTE2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Methotrexate DM2TEOL Anterior urethra cancer Approved [241]
Permethrin DMZ0Q1G Pediculus capitis infestation 1G00.0 Approved [391]
Scriptaid DM9JZ21 Solid tumour/cancer 2A00-2F9Z Preclinical [392]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [27]
Drug(s) Affected By Potassium voltage-gated channel subfamily V member 2 (KCNV2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [47]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [240]
Drug(s) Affected By 3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [166]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [46]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [47]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [43]
Clozapine DMFC71L Schizophrenia 6A20 Approved [149]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [393]
Arsenic DMTL2Y1 N. A. N. A. Approved [394]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [395]
Aminoglutethimide DMWFHMZ Cushing disease 5A70 Approved [396]
Genistein DM0JETC Menopause symptom GA30.0 Phase 2/3 [397]
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Drug(s) Affected By SRC kinase signaling inhibitor 1 (SRCIN1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Fulvestrant DM0YZC6 Breast cancer 2C60-2C65 Approved [27]
Panobinostat DM58WKG Chronic graft versus host disease Approved [59]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [47]
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [223]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [239]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [240]
PMID28870136-Compound-52 DMFDERP N. A. N. A. Patented [367]
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Drug(s) Affected By Pinin (PNN)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Tretinoin DM49DUI Acne vulgaris ED80 Approved [161]
Leflunomide DMR8ONJ Arthritis FA20 Approved [233]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [398]
Sevoflurane DMC9O43 Anaesthesia 9A78.6 Approved [398]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [197]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [43]
Temozolomide DMKECZD Adenocarcinoma 2D40 Approved [49]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [50]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [64]
Piroxicam DMTK234 Osteoarthritis FA00-FA05 Approved [399]
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Drug(s) Affected By PRKR-interacting protein 1 (PRKRIP1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Quercetin DM3NC4M Obesity 5B81 Approved [44]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [166]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [46]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [47]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [50]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [217]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [240]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [291]
Milchsaure DM462BT Pruritus EC90 Investigative [340]
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Drug(s) Affected By Transcription factor COE2 (EBF2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [234]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [43]
Estradiol DMUNTE3 Acne vulgaris ED80 Approved [400]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [217]
Vorinostat DMWMPD4 Adult acute monocytic leukemia Approved [239]
SNDX-275 DMH7W9X Breast cancer 2C60-2C65 Phase 3 [239]
Benzo(a)pyrene DMN7J43 N. A. N. A. Phase 1 [240]
bisphenol A DM2ZLD7 Discovery agent N.A. Investigative [27]
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Drug(s) Affected By Phenylalanine--tRNA ligase beta subunit (FARSB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [64]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [29]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [46]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [234]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [43]
Clozapine DMFC71L Schizophrenia 6A20 Approved [149]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [401]
Cupric Sulfate DMP0NFQ Fungal infection 1F29-1F2F Approved [50]
Irinotecan DMP6SC2 Adenocarcinoma 2D40 Approved [402]
Menadione DMSJDTY Vitamin K deficiency 5B59 Approved [64]
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Drug(s) Affected By Poly polymerase 2 (PARP2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Talazoparib DM1KS78 Breast cancer 2C60-2C65 Approved [403]
Methotrexate DM2TEOL Anterior urethra cancer Approved [241]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [83]
Testosterone DM7HUNW Hot flushes GA30 Approved [68]
Calcitriol DM8ZVJ7 Congenital alopecia LC30 Approved [68]
Leflunomide DMR8ONJ Arthritis FA20 Approved [233]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [169]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [47]
Demecolcine DMCZQGK Solid tumour/cancer 2A00-2F9Z Approved [381]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [293]
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Drug(s) Affected By A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [213]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [101]
Glucosamine DM4ZLFD Osteoarthritis FA00-FA05 Approved [404]
Arsenic trioxide DM61TA4 Acute lymphoblastic leukaemia 2A85 Approved [66]
Aspirin DM672AH Acute coronary syndrome BA41 Approved [405]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [406]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [407]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [234]
Zoledronate DMIXC7G Adenocarcinoma 2D40 Approved [200]
Dexamethasone DMMWZET Acute adrenal insufficiency Approved [291]
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Drug(s) Affected By ALK tyrosine kinase receptor (ALK)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Ceritinib DMB920Z Non-small-cell lung cancer 2C25.Y Approved [408]
Crizotinib DM4F29C Non-small-cell lung cancer 2C25.Y Approved [409]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [410]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [411]
Masoprocol DMMVNZ0 Prostate cancer 2C82.0 Approved [410]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [382]
Amphotericin B DMTAJQE Acne vulgaris ED80 Approved [412]
Arsenic DMTL2Y1 N. A. N. A. Approved [222]
Marinol DM70IK5 Anorexia nervosa cachexia 6B80 Approved [413]
Adenosine triphosphate DM79F6G Malnutrition 5B50-5B71 Approved [414]
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Drug(s) Affected By Proliferation-associated protein 2G4 (PA2G4)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [76]
Quercetin DM3NC4M Obesity 5B81 Approved [44]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [415]
Hydroquinone DM6AVR4 Melasma ED60.1 Approved [416]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [169]
Ivermectin DMDBX5F Intestinal strongyloidiasis due to nematode parasite 1F6B Approved [43]
Folic Acid DMEMBJC Colorectal carcinoma Approved [170]
Ampicillin DMHWE7P Acute epiglottitis Approved [44]
Diethylstilbestrol DMN3UXQ Gonorrheal vaginitis GA02 Approved [401]
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [63]
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Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [259]
Selenium DM25CGV N. A. N. A. Approved [417]
Methotrexate DM2TEOL Anterior urethra cancer Approved [164]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [418]
Epinephrine DM3KJBC Acute asthma CA23 Approved [419]
Quercetin DM3NC4M Obesity 5B81 Approved [420]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [89]
obeticholic acid DM3Q1SM Primary biliary cholangitis DB96.1 Approved [135]
Troglitazone DM3VFPD Diabetic complication 5A2Y Approved [421]
Tretinoin DM49DUI Acne vulgaris ED80 Approved [422]
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Drug(s) Affected By Cytochrome P450 3A5 (CYP3A5)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Eplerenone DMF0NQR Heart failure BD10-BD13 Approved [423]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [424]
Nelfinavir mesylate DMFX6G8 N. A. N. A. Approved [425]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [425]
Ifosfamide DMCT3I8 Adult central nervous system germ cell tumor Approved [426]
Omeprazole DM471KJ Cystic fibrosis CA25 Approved [427]
Thalidomide DM70BU5 Adult T-cell leukemia/lymphoma Approved [428]
Ciclosporin DMAZJFX Graft-versus-host disease 4B24 Approved [46]
Valproate DMCFE9I Epilepsy 8A60-8A68 Approved [47]
Hydrocortisone DMGEMB7 Acne vulgaris ED80 Approved [429]
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Drug(s) Affected By Albumin (ALB)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acetaminophen DMUIE76 Allergic rhinitis CA08.0 Approved [52]
Sulfamethoxazole DMB08GE Acute otitis media AB00 Approved [94]
Tolbutamide DM02AWV Advanced cancer 2A00-2F9Z Approved [430]
Diazepam DM08E9O Alcohol withdrawal Approved [431]
Sertraline DM0FB1J Coronary heart disease BA80.Z Approved [432]
Methimazole DM25FL8 Hyperthyroidism 5A02 Approved [152]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [433]
Colchicine DM2POTE Acute gout flare FA25.0 Approved [434]
Methotrexate DM2TEOL Anterior urethra cancer Approved [435]
Quercetin DM3NC4M Obesity 5B81 Approved [436]
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Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)
Drug Name Drug ID Indication ICD 11 Highest Status REF
Cisplatin DMRHGI9 Adenocarcinoma 2D40 Approved [139]
Doxorubicin DMVP5YE Acute myelogenous leukaemia 2A41 Approved [437]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [438]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [439]
TECFIDERA DM2OVDT Multiple sclerosis 8A40 Approved [440]
Sulindac DM2QHZU Acute myelogenous leukaemia 2A41 Approved [441]
Simvastatin DM30SGU Arteriosclerosis BD40 Approved [442]
Lapatinib DM3BH1Y Breast cancer 2C60-2C65 Approved [418]
Quercetin DM3NC4M Obesity 5B81 Approved [443]
Rofecoxib DM3P5DA Osteoarthritis FA00-FA05 Approved [89]
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Molecular Interaction Atlas of This Drug

Molecular Interaction Atlas
Download the Complete Interaction Atlas for Visualization in Cytoscape

Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Heat shock protein 90 alpha (HSP90A) TT78R5H HS90A_HUMAN Inhibitor [2]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) OT7RJON4 HCD2_HUMAN Gene/Protein Processing [3]
A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1) OTTLJH8W ATS1_HUMAN Gene/Protein Processing [4]
Albumin (ALB) OTVMM513 ALBU_HUMAN Drug Response [5]
ALK tyrosine kinase receptor (ALK) OTV3P4V8 ALK_HUMAN Gene/Protein Processing [6]
Alpha-enolase (ENO1) OTB1KWJS ENOA_HUMAN Gene/Protein Processing [3]
Androgen receptor (AR) OTUBKAZZ ANDR_HUMAN Gene/Protein Processing [7]
Annexin A1 (ANXA1) OT5OFDJC ANXA1_HUMAN Gene/Protein Processing [3]
Anterior gradient protein 2 homolog (AGR2) OTRRZT7W AGR2_HUMAN Gene/Protein Processing [3]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Gene/Protein Processing [8]
Apoptotic protease-activating factor 1 (APAF1) OTJWIVY0 APAF_HUMAN Gene/Protein Processing [9]

References

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