General Information of DME (ID: DECB0K3)

DME Name Cytochrome P450 2D6 (CYP2D6) DME Info
UniProt ID
CP2D6_HUMAN
Gene Name CYP2D6

Molecule-Related Drug & Molecule List

Molecule-Related Drug List
Molecule Type:
DTT
DTP
DME
Drug Status:
Approved Drug(s)
Clinical Trial Drug(s)
Investigative Drug(s)
Discontinued Drug(s)
262 Approved Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Acebutolol DM0TI4U Hypertension BA00-BA04 Approved [1]
Acetaminophen DMUIE76 Pain MG30-MG3Z Approved [2]
Ajmaline DMDJW5K Atrial fibrillation BC81.3 Approved [3]
Almotriptan malate DMFG5ST Migraine 8A80 Approved [4]
Alogliptin DM8WI3R Type-2 diabetes 5A11 Approved [5]
Amiodarone DMUTEX3 Tachyarrhythmias BC71 Approved [6]
Amitriptyline DMK7F9S Depression 6A70-6A7Z Approved [7]
Amoxapine DMKITQE Major depressive disorder 6A70.3 Approved [8]
Amphetamine DMSZQAK Attention deficit hyperactivity disorder 6A05.Z Approved [9]
Amprenavir DMLMXE0 Human immunodeficiency virus infection 1C62 Approved [10]
Amsacrine DMZKYIV Acute lymphoblastic leukaemia 2A85 Approved [11]
Anisodamine DMW51AX Central and peripheral nervous disease 8A04-8E7Z Approved [1]
Aprindine DMBXWU8 Cardiac arrhythmias BC9Z Approved [12]
Arformoterol DMYM974 Chronic obstructive pulmonary disease CA22 Approved [13]
Aripiprazole DM3NUMH Erythropoietic porphyrias 5C58.12 Approved [14]
Artemether DM48QOT Malaria 1F40-1F45 Approved [15]
Asenapine DMSQZE2 Schizophrenia 6A20 Approved [16]
Atenolol DMNKG1Z Hypertension BA00-BA04 Approved [1]
Atomoxetine DM5L6HI Attention deficit hyperactivity disorder 6A05.Z Approved [17]
Azelastine DMXTMBJ Allergic conjunctivitis 9A60.02 Approved [18]
Benzatropine DMF7EXL Psychomotor agitation MB23.M Approved [19]
Benzyl alcohol DMBVYDI Head and body lice 1G00.0 Approved [20]
Bepridil DM0RKS4 Chronic/stable angina BA40.1 Approved [21]
Betaxolol DM6EUL5 Hypertension BA00-BA04 Approved [22]
Bevantolol DMZFICR Hypertension BA00-BA04 Approved [1]
Bisoprolol DM3UZ95 Hypertension BA00-BA04 Approved [23]
Bopindolol DMIFYLX Hypertension BA00-BA04 Approved [1]
Bortezomib DMNO38U Mantle cell lymphoma 2A85.5 Approved [24]
Buflomedil DMG1OPF Peripheral vascular disease BD4Z Approved [25]
Bupivacaine DM4PRFC Anaesthesia 9A78.6 Approved [26]
Buprenorphine DMPRI8G Pain MG30-MG3Z Approved [27]
Bupropion DM5PCS7 Smoking dependence 6C4A.2 Approved [28]
Buspirone DMBS632 Anxiety disorder 6B00-6B0Z Approved [29]
Caffeine DMKBJWP Orthostatic hypotension BA21 Approved [30]
Cannabidiol DM0659E Dravet syndrome 8A61.11 Approved [31]
Capsaicin DMGMF6V Neuropathic pain 8E43.0 Approved [32]
Captopril DM458UM Hypertension BA00-BA04 Approved [3]
Cariprazine DMJYDVK Bipolar disorder 6A60 Approved [33]
Carteolol DMFMDOB Glaucoma/ocular hypertension 9C61 Approved [34]
Carvedilol DMHTEAO Congestive heart failure BD10 Approved [24]
Celecoxib DM6LOQU Rheumatoid arthritis FA20 Approved [35]
Cephalexin DMD5JU8 Bacterial infection 1A00-1C4Z Approved [36]
Cevimeline DMWSMND Sjogren syndrome 4A43.20 Approved [37]
Chloroquine DMSI5CB Malaria 1F40-1F45 Approved [38]
Chlorpheniramine DM5URA2 Allergic rhinitis CA08.0 Approved [39]
Chlorpromazine DMBGZI3 Schizophrenia 6A20 Approved [40]
Chlorzoxazone DMCYVDT Acute pain MG31 Approved [41]
Ciclesonide DM2NA4K Asthma CA23 Approved [42]
Cilostazol DMZMSCT Intermittent claudication BD40.00 Approved [43]
Cinacalcet DMCX0K3 Hyperparathyroidism 5A51 Approved [44]
Cinnarizine DM7U5QJ Vertigo meniere disease AB31.0 Approved [24]
Citalopram DM2G9AE Depression 6A70-6A7Z Approved [45]
Clevidipine butyrate DMW4M97 Hypertension BA00-BA04 Approved [46]
Clofibrate DMPC1J7 Dysbetalipoproteinemia 5C80.2 Approved [47]
Clomifene DMKI7RB Female infertility GA31.Z Approved [48]
Clonidine DM6RZ9Q Hypertension BA00-BA04 Approved [49]
Clozapine DMFC71L Schizophrenia 6A20 Approved [50]
Cobicistat DM6L4H2 Human immunodeficiency virus infection 1C62 Approved [51]
Cocaine DMSOX7I Anaesthesia 9A78.6 Approved [52]
Codeine DMJX6ZG Pain MG30-MG3Z Approved [53]
Cyclobenzaprine DM1YBRM Depression 6A70-6A7Z Approved [54]
Dacomitinib DMOH8VY Non-small-cell lung cancer 2C25.Y Approved [55]
Dapagliflozin DM28UJG Type-2 diabetes 5A11 Approved [56]
Darifenacin DMWXLYZ Overactive bladder GC50.0 Approved [57]
Debrisoquin DMC50ME Hypertension BA00-BA04 Approved [58]
Delavirdine DM3NF5G Human immunodeficiency virus infection 1C62 Approved [59]
Desipramine DMT2FDC Attention deficit hyperactivity disorder 6A05.Z Approved [60]
Desvenalfaxine succinate DMJE6KO Fibromyalgia MG30.01 Approved [61]
Deutetrabenazine DMUPFLI Huntington disease 8A01.10 Approved [62]
Dexchlorpheniramine maleate DMA8DPN Rhinitis FA20 Approved [39]
Dextroamphetamine DMMIHVP Attention deficit hyperactivity disorder 6A05.Z Approved [9]
Dextromethorphan DMUDJZM Cough MD12 Approved [53]
Dextropropoxyphene DM23HCX Pain MG30-MG3Z Approved [63]
Diltiazem DMAI7ZV Hypertension BA00-BA04 Approved [64]
Diphenhydramine DMKQTBA Meniere disease AB31.0 Approved [65]
Dolasetron DMMG26Z Nausea MD90 Approved [66]
Domperidone DMBDPY0 Gastrointestinal disease DE2Z Approved [67]
Donepezil DMIYG7Z Alzheimer disease 8A20 Approved [68]
Dopamine DMPGUCF Parkinson disease 8A00.0 Approved [69]
Doxazosin DM9PLRH Hypertension BA00-BA04 Approved [70]
Doxepin DMPI98T Depression 6A70-6A7Z Approved [71]
Doxorubicin DMVP5YE Solid tumour/cancer 2A00-2F9Z Approved [72]
Dronedarone DMA8FS5 Angina pectoris BA40 Approved [73]
Duloxetine DM9BI7M Depression 6A70-6A7Z Approved [74]
Dutasteride DMQ4TJK Benign prostatic hyperplasia GA90 Approved [74]
Eletriptan DMW649X Migraine 8A80 Approved [75]
Eliglustat tartrate DMSRZAO Metabolic disorder 5C50-5D2Z Approved [76]
Emetine DMCT2YF Hepatitis virus infection 1E50-1E51 Approved [77]
Epinastine DMX0K3Q Allergic conjunctivitis 9A60.02 Approved [78]
Erlotinib DMCMBHA Non-small-cell lung cancer 2C25.Y Approved [79]
Escitalopram DMFK9HG Major depressive disorder 6A70.3 Approved [80]
Esmolol DM51TYR Acute supraventricular tachycardia BC81 Approved [1]
Fesoterodine fumarate DM13495 Overactive bladder GC50.0 Approved [81]
Flecainide DMSQDLE Tachyarrhythmias BC71 Approved [82]
Flunarizine DMZU5JP Migraine 8A80 Approved [24]
Fluoxetine DM3PD2C Depression 6A70-6A7Z Approved [83]
Fluphenazine DMIT8LX Psychotic disorder 6A20-6A25 Approved [50]
Fluvastatin DM4MDJY Hypercholesterolaemia 5C80.0 Approved [84]
Formoterol DMSOURV Asthma CA23 Approved [13]
Fusidic acid DMWVCF3 Bacterial infection 1A00-1C4Z Approved [85]
Galantamine DMEO794 Alzheimer disease 8A20 Approved [86]
Gefitinib DM15F0X Solid tumour/cancer 2A00-2F9Z Approved [87]
Granisetron DMIUW25 Nausea and vomiting MD90 Approved [88]
Halofantrine DMOMK1V Malaria 1F40-1F45 Approved [38]
Haloperidol DM96SE0 Schizophrenia 6A20 Approved [40]
Halothane DM80OZ5 Anaesthesia 9A78.6 Approved [3]
Hydrocodone bitartrate DMIAPBE Neuropathic pain 8E43.0 Approved [89]
Hydrogen peroxide DM1NG5W Infectious disease 1A00-CA43.1 Approved [90]
Hydromorphone DMHP21E Pain MG30-MG3Z Approved [91]
Ibrutinib DMHZCPO Mantle cell lymphoma 2A85.5 Approved [92]
Idarubicin DMM0XGL Acute myeloid leukaemia 2A60 Approved [93]
Iloperidone DM6AUFY Schizophrenia 6A20 Approved [94]
Imatinib DM7RJXL Acute lymphoblastic leukaemia 2A85 Approved [24]
Imipramine DM2NUH3 Depression 6A70-6A7Z Approved [95]
Incruse ellipta DM32GSJ Chronic obstructive pulmonary disease CA22 Approved [96]
Indinavir DM0T3YH Human immunodeficiency virus infection 1C62 Approved [97]
Ipecac DMLZTP9 Poison intoxication NE6Z Approved [98]
Istradefylline DM20VSK Parkinson disease 8A00.0 Approved [99]
Labetalol DMK8U72 Hypertension BA00-BA04 Approved [100]
Levobetaxolol DMSREPX Chronic open-angle glaucoma 9C61.0 Approved [1]
Levobunolol DMTNFCQ Open-angle glaucoma 9C61 Approved [1]
Levodopa DMN3E57 Parkinson disease 8A00.0 Approved [101]
Levomepromazine DMIKFEL Bipolar disorder 6A60 Approved [102]
Levomilnacipran DMV26S8 Fibromyalgia MG30.01 Approved []
Lidocaine DML4ZOT Anaesthesia 9A78.6 Approved [103]
Lisdexamfetamine DM6W8V5 Attention deficit hyperactivity disorder 6A05.Z Approved [104]
Lisuride DMCME17 Parkinson disease 8A00.0 Approved [105]
Lofexidine DM1WXA6 Heroin and opiate withdrawal 6C43 Approved [106]
Loperamide DMOJZQ9 Diarrhea ME05.1 Approved [107]
Loratadine DMF3AN7 Allergy 4A80-4A85 Approved [108]
Lorcaserin DMG6OYJ Obesity 5B81 Approved [109]
Loxapine DM8AI9U Schizophrenia 6A20 Approved [110]
Luvox DMJKROX Anxiety disorder 6B00-6B0Z Approved [111]
Maprotiline DMPWB7T Major depressive disorder 6A70.3 Approved [112]
Meclizine DMS7T13 Dizziness MB48 Approved [113]
Meperidine DMX4GND Pain MG30-MG3Z Approved [114]
Mephenytoin DM5UGDK Epilepsy 8A60-8A68 Approved [115]
Mepindolol DMUDWP9 Angina pectoris BA40 Approved [1]
Mequitazine DMAFBCY Allergic rhinitis CA08.0 Approved [116]
Mesoridazine DM2ZGAN Schizophrenia 6A20 Approved [117]
Methadone DMTW6IU Dry cough MD12 Approved [118]
Methamphetamine DMPM4SK Attention deficit hyperactivity disorder 6A05.Z Approved [119]
Methamphetamine hydrochloride DMO2JBC Attention deficit hyperactivity disorder 6A05.Z Approved [119]
Methoxyflurane DML0RAE Anaesthesia 9A78.6 Approved [120]
Methyldopa DM5I621 Hypertension BA00-BA04 Approved [121]
Methyprylon DMBW7VH Insomnia 7A00-7A0Z Approved [122]
Metipranolol DMJMVKI Open-angle glaucoma 9C61 Approved [1]
Metoclopramide DMFA5MY Nausea MD90 Approved [123]
Metoprolol DMOJ0V6 Hypertension BA00-BA04 Approved [124]
Mexiletine DMCTE9R Ventricular tachycardia BC71 Approved [125]
Mianserin DMVKA4O Depression 6A70-6A7Z Approved [126]
Midodrine DME2PY5 Orthostatic hypotension BA21 Approved [127]
Minaprine DM0EP7M Depression 6A70-6A7Z Approved [128]
Mirabegron DMS1GYT Overactive bladder GC50.0 Approved [129]
Mirtazapine DML53ZJ Depression 6A70-6A7Z Approved [130]
Moclobemide DMNZWL7 Depression 6A70-6A7Z Approved [131]
Morphine DMRMS0L Chronic pain MG30 Approved [132]
Nateglinide DMLK2QH Diabetic complication 5A2Y Approved [133]
Nebivolol DM7F1PA Hypertension BA00-BA04 Approved [134]
Nefazodone DM4ZS8M Major depressive disorder 6A70.3 Approved [135]
Nevirapine DM6HX9B Human immunodeficiency virus infection 1C62 Approved [136]
Nicardipine DMCDYW7 High blood pressure BA00 Approved [137]
Nicergoline DMBCM8L Brain ischaemia 8B1Z Approved [138]
Nicotine DMWX5CO Nicotine dependence 6C4A.2 Approved [139]
Nifedipine DMSVOZT Angina pectoris BA40 Approved [140]
Nitrofurazone DMSM2KE Skin burns ME65.0 Approved [141]
Nortriptyline DM4KDYJ Depression 6A70-6A7Z Approved [142]
Olanzapine DMPFN6Y Schizophrenia 6A20 Approved [143]
Oliceridine DM6MDCF Acute pain MG31 Approved [144]
Ondansetron DMOTQ1I Chemotherapy-induced nausea MD90 Approved [145]
OPC-34712 DMHG57U Major depressive disorder 6A70.3 Approved [146]
Opipramol DMPUOXF Anxiety disorder 6B00-6B0Z Approved [3]
Oxamniquine DM2QDX1 Schistosomiasis 1F86 Approved [147]
Oxatomide DM1F42Z Hay fever CA08.00 Approved [148]
Oxprenolol DM51OQW Hypertension BA00-BA04 Approved [1]
Oxymorphone DM65AGJ Pain MG30-MG3Z Approved [149]
Paliperidone DM7NPJS Schizophrenia 6A20 Approved [150]
Palonosetron DMBHMOX Nausea MD90 Approved [145]
Paroxetine DM5PVQE Depression 6A70-6A7Z Approved [151]
Pazopanib DMF57DM Renal cell carcinoma 2C90 Approved [152]
Penbutolol DM4ES8F Hypertension BA00-BA04 Approved [1]
Pentamidine DMHZJCG Fungal infection 1F29-1F2F Approved [153]
Perazine DM2AOTZ Psychotic disorder 6A20-6A25 Approved [154]
Perhexiline DMINO7Z Angina pectoris BA40 Approved [155]
Perospirone DMVHJLX Psychotic disorder 6A20-6A25 Approved [156]
Perphenazine DMA4MRX Schizophrenia 6A20 Approved [40]
Pimozide DMW83TP Schizophrenia 6A20 Approved [157]
Piperazine DMTY9LU Ascariasis 1F62 Approved [158]
Pipotiazine DMC68DF Schizophrenia 6A20 Approved [159]
Ponatinib DMYGJQO Acute lymphoblastic leukaemia 2A85 Approved [160]
Practolol DMGLZ26 Cardiac arrhythmias BC9Z Approved [1]
Procainamide DMNMXR8 Ventricular arrhythmias BC71 Approved [161]
Prochlorperazine DM53SRA Nausea MD90 Approved [162]
Progesterone DMUY35B Premature labour JB00 Approved [163]
Prolixin decanoate DMMJ1IS Schizophrenia 6A20 Approved [50]
Promethazine DM6I5GR Nausea MD90 Approved [127]
Propafenone DMPIBJK Tachyarrhythmias BC71 Approved [164]
Propofol DMB4OLE Anaesthesia 9A78.6 Approved [165]
Propranolol DM79NTF Migraine 8A80 Approved [166]
Pyrantel DMG2X3E Worm infection 1F90.Z Approved [153]
Quetiapine DM1N62C Schizophrenia 6A20 Approved [167]
Quinidine DMLPICK Tachyarrhythmias BC71 Approved [168]
Quinine DMSWYF5 Malaria 1F40-1F45 Approved [169]
Ranitidine DM0GUSX Peptic ulcer DA61 Approved [170]
Ranolazine DM0C9IL Chronic/stable angina BA40.1 Approved [171]
Revefenacin DMMP5SI Chronic obstructive pulmonary disease CA22 Approved [172]
Rifampicin DM5DSFZ Osteoporosis FB83.0 Approved [173]
Risperidone DMN6DXL Schizophrenia 6A20 Approved [174]
Ritonavir DMU764S Human immunodeficiency virus infection 1C62 Approved [175]
Ropivacaine DMSPJG2 Anaesthesia 9A78.6 Approved [3]
Rucaparib DM9PVX8 Ovarian cancer 2C73 Approved []
Saquinavir DMG814N Human immunodeficiency virus infection 1C62 Approved [97]
Selegiline hydrochloride DM3VR1L Parkinson disease 8A00.0 Approved [176]
Sertraline DM0FB1J Depression 6A70-6A7Z Approved [177]
Sildenafil citrate DMSWJ5X Erectile dysfunction HA01.1 Approved [24]
Simvastatin DM30SGU Hypercholesterolaemia 5C80.0 Approved [178]
Solifenacin DMG592Q Overactive bladder GC50.0 Approved [179]
Sotalol DML60TN Sinus rhythm disorder BC9Y Approved [1]
Tafenoquine DM1XT4N Malaria 1F40-1F45 Approved [180]
Tamoxifen DMLB0EZ Breast cancer 2C60-2C65 Approved [181]
Tamsulosin DM5QF9V Benign prostatic hyperplasia GA90 Approved [182]
Tapentadol hydrochloride DMXLSH3 Acute pain MG31 Approved [183]
Tegaserod DM3XYD1 Irritable bowel syndrome DD91.0 Approved [184]
Tertatolol DM2L3D5 Hypertension BA00-BA04 Approved [1]
Tetrabenazine DMYWQ0O Huntington disease 8A01.10 Approved [185]
Theophylline DMRJFN9 Chronic obstructive pulmonary disease CA22 Approved [186]
Thioridazine DM35M8J Schizophrenia 6A20 Approved [117]
Ticlopidine DMO946V Stroke 8B20 Approved [187]
Timolol DM3NXRU High blood pressure BA00 Approved [188]
Tipranavir DM8HJX6 Human immunodeficiency virus infection 1C62 Approved [189]
Tolperisone DMA2GHJ Muscle spasm MB47.3 Approved [190]
Tolterodine DMSHPW8 Overactive bladder GC50.0 Approved [191]
Trabectedin DMG3Y89 Solid tumour/cancer 2A00-2F9Z Approved [192]
Tramadol DMRQD04 Pain MG30-MG3Z Approved [193]
Trazodone DMK1GBJ Depression 6A70-6A7Z Approved [194]
Triclabendazole DMPWGBR Helminth infection 1F90.0 Approved [195]
Trimipramine DM1SC8M Major depressive disorder 6A70.3 Approved [196]
Tropisetron DMNSJ7V Fibromyalgia MG30.01 Approved [145]
Upadacitinib DM8T2OI Rheumatoid arthritis FA20 Approved [197]
Venlafaxine DMR6QH0 Depression 6A70-6A7Z Approved [198]
Vilazodone DM4LECQ Major depressive disorder 6A70.3 Approved [199]
Vinblastine DM5TVS3 Solid tumour/cancer 2A00-2F9Z Approved [72]
Vincamine DMK1ZOR Cerebrovascular disease 8B2Z Approved [200]
Vinorelbine DMVXFYE Solid tumour/cancer 2A00-2F9Z Approved [72]
Vortioxetine DM6F1PU Major depressive disorder 6A70.3 Approved [201]
Yohimbine DMJCP1Y Erectile dysfunction HA01.1 Approved [202]
Zalcitabine DMH7MUV Human immunodeficiency virus infection 1C62 Approved [203]
Zolpidem DMWOSKJ Insomnia 7A00-7A0Z Approved [204]
Zotepine DMF3VXA Anxiety disorder 6B00-6B0Z Approved [205]
Zuclopenthixol DMKYD5N Schizophrenia 6A20 Approved [206]
Aminophenazone DMY2AH1 Anaesthesia 9A78.6 Phase 4 [207]
Arotinolol DML1VXW Essential tremor or related tremors 8A04.1 Phase 4 [1]
Benzethonium DMHKZX1 Staphylococcus infection 1B5Y Phase 4 [19]
Celiprolol DMYTGW0 Essential hypertension BA00 Phase 4 [1]
Chlorphenamine DM6C4YJ Allergy 4A80-4A85 Phase 4 [39]
Cibenzoline DMBG0N4 Atrial fibrillation BC81.3 Phase 4 [208]
Dapoxetine DMV6KFY Premature ejaculation HA03.0Z Phase 4 [209]
Dihydrocodeine DMB0FWL Cancer related pain MG30 Phase 4 [210]
Esmirtazapine DMKEGI3 Depression 6A70-6A7Z Phase 4 [211]
Guanoxan DMLYXBF Essential hypertension BA00 Phase 4 [3]
Indenolol DM2R496 Cardiac arrhythmias BC9Z Phase 4 [1]
Vonoprazan DMCOJPS Gastro-oesophageal reflux DA22 Phase 4 [212]
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⏷ Show the Full List of 262 Approved Drug(s)
32 Clinical Trial Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Azimilide DMUIBV8 Atrial fibrillation BC81.3 Phase 3 [213]
Bicifadine DM42GP9 Chronic low back pain MG30.02 Phase 3 [214]
FT-0710230 DMF4I1V Opioid dependence 6C43.2Z Phase 3 [215]
Iclaprim DM7YNV9 Bacterial infection 1A00-1C4Z Phase 3 [216]
Karenitecin DMCRGY4 Lung cancer 2C25.0 Phase 3 [217]
LU AE58054 DMWGRQD Schizophrenia 6A20 Phase 3 [218]
Muraglitazar DMG3NFZ N. A. N. A. Phase 3 [219]
Nabiximols DMHKJ5I Cancer related pain MG30 Phase 3 [31]
NBI-98854 DMVO1C0 Movement disorder 8A07-8A0Z Phase 3 [220]
Netupitant DMEKAYI Chemotherapy-induced nausea MD90 Phase 3 [221]
Olodaterol/tiotropium bromide DM1FBZ7 Chronic obstructive pulmonary disease CA22 Phase 3 [222]
ONO-1101 DMU86DM Atrial fibrillation BC81.3 Phase 3 [1]
Vernakalant DMOQ81Y Atrial fibrillation BC81.3 Phase 3 [223]
Bucindolol DMV52CP Atrial fibrillation BC81.3 Phase 2/3 [1]
Fexinidazole DMOYE70 Trypanosomiasis 1D51-1F53 Phase 2/3 [224]
Pactimibe DM0NZDT Arteriosclerosis BD40 Phase 2/3 [225]
BCP-13498 DM2BO9W Anaesthesia 9A78.6 Phase 2 [226]
BMS 650032 DMQI43G Hepatitis C virus infection 1E51.1 Phase 2 [227]
CP-122721 DMSWLM5 Major depressive disorder 6A70.3 Phase 2 [228]
Ferroquine DMICMXE Malaria 1F40-1F45 Phase 2 [229]
GSK683699 DMTW79H Inflammatory bowel disease DD72 Phase 2 [230]
LY2603618 DMCXRZF Pancreatic cancer 2C10 Phase 2 [231]
Prajmaline DMIVMR3 Atherosclerosis BD40 Phase 2 [232]
Roxatidine DMIZMYQ Gastro-oesophageal reflux DA22 Phase 2 [233]
Sitamaquine DMY3JWO Infectious disease 1A00-CA43.1 Phase 2 [234]
SQ-109 DMWK9BX Bacterial infection 1A00-1C4Z Phase 2 [235]
Sun13834 DMPK34E Gram-positive bacterial infection 1B74-1G40 Phase 2 [3]
H3B-6545 DMIFCY2 Breast cancer 2C60-2C65 Phase 1/2 [236]
ABT-333 DM7TOWX Hepatitis C virus infection 1E51.1 Phase 1 [237]
ITX-5061 DM702MU Human immunodeficiency virus-1 infection 1C62 Phase 1 [238]
NSC-172130 DM6093Y Depression 6A70-6A7Z Phase 1 [239]
Salvinorin A DMJ3HQY Cerebral vasospasm BA85.Z Phase 1 [240]
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⏷ Show the Full List of 32 Clinical Trial Drug(s)
23 Discontinued Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Alprenolol DMYJ8Z3 Hypertension BA00-BA04 Withdrawn from market [102]
Astemizole DM2HN6Q Allergic rhinitis CA08.0 Withdrawn from market [241]
Dexfenfluramine DMJ7YDS Obesity 5B81 Withdrawn from market [242]
Encainide DMK0GHV Heart arrhythmia BC65 Withdrawn from market [243]
Indoramin DMNSJFD Hypertension BA00-BA04 Withdrawn from market [3]
Phenacetin DMRQAM0 Analgesia MB40.8 Withdrawn from market [244]
Phenformin DMQ52JG Diabetic complication 5A2Y Withdrawn from market [52]
Remoxipride DMGQF3R Schizophrenia 6A20 Withdrawn from market [3]
Sertindole DMMP65N Schizophrenia 6A20 Withdrawn from market [245]
Terfenadine DM4KLPT Allergy 4A80-4A85 Withdrawn from market [78]
Epanolol DML1Y49 Angina pectoris BA40 Discontinued in Preregistration [1]
Etilevodopa DMF93U1 Parkinson disease 8A00.0 Discontinued in Phase 3 [246]
Sabeluzole DMSW051 Cerebrovascular ischaemia 8B1Z Discontinued in Phase 3 [247]
Octopamine DMLQVTJ Thrombosis DB61-GB90 Discontinued in Phase 2a [248]
Benzydamine DMEQL9U Chemotherapy or radiotherapy-induced mucositis DA42-DA60 Discontinued in Phase 2 [249]
BMS-181101 DMT4VSE Mood disorder 6A60-6E23 Discontinued in Phase 2 [250]
Brofaromine DMTEQ0G Anxiety disorder 6B00-6B0Z Discontinued in Phase 2 [251]
Ezlopitant DMTUPZ2 Irritable bowel syndrome DD91.0 Discontinued in Phase 2 [252]
MCPP DMIG5W8 Mood disorder 6A60-6E23 Discontinued in Phase 2 [253]
Nemifitide DM6VP9U Major depressive disorder 6A70.3 Discontinued in Phase 2 [254]
Tesmilifene DMPB36I Breast cancer 2C60-2C65 Discontinued in Phase 2 [255]
VR-776 DMFQWNI Premature ejaculation HA03.0Z Discontinued in Phase 1 [256]
Gepirone DMGX5Q0 Depression 6A70-6A7Z Terminated [258]
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⏷ Show the Full List of 23 Discontinued Drug(s)
1 Preclinical Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
Oxycodone hydrochloride DMCA7LN Chronic pain MG30 Application submitted [257]
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16 Investigative Drug(s) Transported by This DTP
Drug Name Drug ID Indication ICD 11 Highest Status REF
5-MEO-DMT DMG0EL7 Discovery agent N.A. Investigative [259]
Befunolol DMV15JC Glaucoma/ocular hypertension 9C61 Investigative [1]
Beta-methoxyamphetamine DMA9CSG Discovery agent N.A. Investigative [260]
Bufuralol DMJSC07 Cardiac arrhythmias BC9Z Investigative [261]
Bupranolol DMUT9IQ Tachyarrhythmias BC71 Investigative [3]
Butyrfentanyl DM9X2FV Anaesthesia 9A78.6 Investigative [262]
Chloroxylenol DMM75WZ Pseudomonas infection 1B92 Investigative [3]
Cloranolol DMH7GKB Discovery agent N.A. Investigative [1]
Ethylmorphine DM0YROF Discovery agent N.A. Investigative [263]
Etilamfetamine DMR9YL6 Pulmonary hypertension BB01 Investigative [9]
Lorpiprazole DMK5J9M Anxiety disorder 6B00-6B0Z Investigative [264]
Methoxyphenamine DMN8HRU Chronic obstructive pulmonary disease CA22 Investigative [265]
Methylenedioxymethamphetamine DMYVU47 Discovery agent N.A. Investigative [266]
Phenazone DMCE985 Discovery agent N.A. Investigative [267]
Repinotan DM47TSV Discovery agent N.A. Investigative [268]
Sparteine DMWCIMG Cardiac arrhythmias BC9Z Investigative [119]
------------------------------------------------------------------------------------
⏷ Show the Full List of 16 Investigative Drug(s)
Molecule Interaction Atlas

References

1 Application of substrate depletion assay to evaluation of CYP isoforms responsible for stereoselective metabolism of carvedilol. Drug Metab Pharmacokinet. 2016 Dec;31(6):425-432.
2 Metabolic interactions between acetaminophen (paracetamol) and two flavonoids, luteolin and quercetin, through in-vitro inhibition studies. J Pharm Pharmacol. 2017 Dec;69(12):1762-1772.
3 Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
4 Clinical pharmacokinetics of almotriptan, a serotonin 5-HT(1B/1D) receptor agonist for the treatment of migraine. Clin Pharmacokinet. 2005;44(3):237-46.
5 An update on the clinical pharmacology of the dipeptidyl peptidase 4 inhibitor alogliptin used for the treatment of type 2 diabetes mellitus. Clin Exp Pharmacol Physiol. 2015 Dec;42(12):1225-38.
6 Potentially significant drug interactions of class III antiarrhythmic drugs. Drug Saf. 2003;26(6):421-38.
7 Bioactivation of the tricyclic antidepressant amitriptyline and its metabolite nortriptyline to arene oxide intermediates in human liver microsomes and recombinant P450s. Chem Biol Interact. 2008 May 9;173(1):59-67.
8 Addition of amoxapine improves positive and negative symptoms in a patient with schizophrenia. Ther Adv Psychopharmacol. 2013 Dec;3(6):340-2.
9 Involvement of CYP2D6 in the in vitro metabolism of amphetamine, two N-alkylamphetamines and their 4-methoxylated derivatives. Xenobiotica. 1999 Jul;29(7):719-32.
10 Amprenavir: a new human immunodeficiency virus type 1 protease inhibitor. Clin Ther. 2000 May;22(5):549-72.
11 Phase I pharmacokinetic study of the novel antitumor agent SR233377. Clin Cancer Res. 2000 Aug;6(8):3088-94.
12 Nonlinear mixed effects model analysis of the pharmacokinetics of routinely administered bepridil in Japanese patients with arrhythmias. Biol Pharm Bull. 2006 Mar;29(3):517-21.
13 A comparison of the expression and metabolizing activities of phase I and II enzymes in freshly isolated human lung parenchymal cells and cryopreserved human hepatocytes. Drug Metab Dispos. 2007 Oct;35(10):1797-805.
14 Aripiprazole: a review of its use in schizophrenia and schizoaffective disorder. Drugs. 2004;64(15):1715-36.
15 The contribution of the enzymes CYP2D6 and CYP2C19 in the demethylation of artemether in healthy subjects. Eur J Drug Metab Pharmacokinet. 1998 Jul-Sep;23(3):429-36.
16 Asenapine review, part I: chemistry, receptor affinity profile, pharmacokinetics and metabolism. Expert Opin Drug Metab Toxicol. 2014 Jun;10(6):893-903.
17 Atomoxetine: a review of its pharmacokinetics and pharmacogenomics relative to drug disposition. J Child Adolesc Psychopharmacol. 2016 May;26(4):314-26.
18 Inhibitory effects of azelastine and its metabolites on drug oxidation catalyzed by human cytochrome P-450 enzymes. Drug Metab Dispos. 1999 Jul;27(7):792-7.
19 Transport, metabolism, and in vivo population pharmacokinetics of the chloro benztropine analogs, a class of compounds extensively evaluated in animal models of drug abuse. J Pharmacol Exp Ther. 2007 Jan;320(1):344-53.
20 Mechanism of cytochrome P4503A4- and 2D6-catalyzed dehydrogenation of ezlopitant as probed with isotope effects using five deuterated analogs. Drug Metab Dispos. 2001 Dec;29(12):1599-607.
21 Serum flecainide S/R ratio reflects the CYP2D6 genotype and changes in CYP2D6 activity. Drug Metab Pharmacokinet. 2015 Aug;30(4):257-62.
22 Association of CYP2D6 and ADRB1 genes with hypotensive and antichronotropic action of betaxolol in patients with arterial hypertension. Fundam Clin Pharmacol. 2007 Aug;21(4):437-43.
23 Drug-drug interactions of beta-adrenoceptor blockers. Arzneimittelforschung. 2003;53(12):814-22.
24 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
25 DMW/ISSX 2000 Meeting. The Drug Metabolism Workshop/International Society for the Study of Xenobiotics. St. Andrews, Scotland, June 11-16, 2000. Abstracts. Drug Metab Rev. 2000;32 Suppl 1:1-136.
26 Oxidative metabolism of bupivacaine into pipecolylxylidine in humans is mainly catalyzed by CYP3A. Drug Metab Dispos. 2000 Apr;28(4):383-5.
27 Effect of nonspecific binding to microsomes and metabolic elimination of buprenorphine on the inhibition of cytochrome P4502D6. Biol Pharm Bull. 2005 Feb;28(2):212-6.
28 In vitro to in vivo extrapolation of the complex drug-drug interaction of bupropion and its metabolites with CYP2D6; simultaneous reversible inhibition and CYP2D6 downregulation. Biochem Pharmacol. 2017 Jan 1;123:85-96.
29 Cytochrome P450 3A-mediated metabolism of buspirone in human liver microsomes. Drug Metab Dispos. 2005 Apr;33(4):500-7.
30 Determinants of interindividual variability and extent of CYP2D6 and CYP1A2 inhibition by paroxetine and fluvoxamine in vivo. J Clin Psychopharmacol. 1998 Jun;18(3):198-207.
31 Exogenous cannabinoids as substrates, inhibitors, and inducers of human drug metabolizing enzymes: a systematic review. Drug Metab Rev. 2014 Feb;46(1):86-95.
32 Metabolism of capsaicin by cytochrome P450 produces novel dehydrogenated metabolites and decreases cytotoxicity to lung and liver cells. Chem Res Toxicol. 2003 Mar;16(3):336-49.
33 Cariprazine: chemistry, pharmacodynamics, pharmacokinetics, and metabolism, clinical efficacy, safety, and tolerability. Expert Opin Drug Metab Toxicol. 2013 Feb;9(2):193-206.
34 Involvement of CYP2D1 in the metabolism of carteolol by male rat liver microsomes. Xenobiotica. 1997 Nov;27(11):1121-9.
35 Celecoxib is a substrate of CYP2D6: impact on celecoxib metabolism in individuals with CYP2C9*3 variants. Drug Metab Pharmacokinet. 2018 Oct;33(5):219-227.
36 Population pharmacokinetic analysis of mirtazapine. Eur J Clin Pharmacol. 2004 Sep;60(7):473-80.
37 Pharmacokinetics and metabolism of the novel muscarinic receptor agonist SNI-2011 in rats and dogs. Arzneimittelforschung. 2003;53(1):26-33.
38 Halofantrine and chloroquine inhibit CYP2D6 activity in healthy Zambians. Br J Clin Pharmacol. 1998 Mar;45(3):315-7.
39 The roles of CYP2D6 and stereoselectivity in the clinical pharmacokinetics of chlorpheniramine. Br J Clin Pharmacol. 2002 May;53(5):519-25.
40 Use of antidepressant drugs in schizophrenic patients with depression. Encephale. 2006 Mar-Apr;32(2 Pt 1):263-9.
41 Prediction of human liver microsomal oxidations of 7-ethoxycoumarin and chlorzoxazone with kinetic parameters of recombinant cytochrome P-450 enzymes. Drug Metab Dispos. 1999 Nov;27(11):1274-80.
42 Identification of enzymes involved in phase I metabolism of ciclesonide by human liver microsomes. Eur J Drug Metab Pharmacokinet. 2005 Oct-Dec;30(4):275-86.
43 Effects of CYP3A inhibition on the metabolism of cilostazol. Clin Pharmacokinet. 1999;37 Suppl 2:61-8.
44 Clinical pharmacokinetic and pharmacodynamic profile of cinacalcet hydrochloride. Clin Pharmacokinet. 2009;48(5):303-11.
45 Pharmacokinetic-pharmacodynamic relationship of the selective serotonin reuptake inhibitors. Clin Pharmacokinet. 1996 Dec;31(6):444-69.
46 Human cytochrome p450 induction and inhibition potential of clevidipine and its primary metabolite h152/81. Drug Metab Dispos. 2006 May;34(5):734-7.
47 Oxidative metabolism of flunarizine and cinnarizine by microsomes from B-lymphoblastoid cell lines expressing human cytochrome P450 enzymes. Biol Pharm Bull. 1996 Nov;19(11):1511-4.
48 CYP2D6 is primarily responsible for the metabolism of clomiphene. Drug Metab Pharmacokinet. 2008;23(2):101-5.
49 CYP2D6 mediates 4-hydroxylation of clonidine in vitro: implication for pregnancy-induced changes in clonidine clearance. Drug Metab Dispos. 2010 Sep;38(9):1393-6.
50 Effect of antipsychotic drugs on human liver cytochrome P-450 (CYP) isoforms in vitro: preferential inhibition of CYP2D6. Drug Metab Dispos. 1999 Sep;27(9):1078-84.
51 Cobicistat versus ritonavir boosting and differences in the drug-drug interaction profiles with co-medications. J Antimicrob Chemother. 2016 Jul;71(7):1755-8.
52 Neuronal cytochrome P450IID1 (debrisoquine/sparteine-type): potent inhibition of activity by (-)-cocaine and nucleotide sequence identity to human hepatic P450 gene CYP2D6. Mol Pharmacol. 1991 Jul;40(1):63-8.
53 Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part I. Clin Pharmacokinet. 2009;48(11):689-723.
54 Identification of human liver cytochrome P450 isoforms involved in the in vitro metabolism of cyclobenzaprine. Drug Metab Dispos. 1996 Jul;24(7):786-91.
55 Phase 1 study to investigate the pharmacokinetic properties of dacomitinib in healthy adult Chinese subjects genotyped for CYP2D6. Xenobiotica. 2018 May;48(5):459-466.
56 Clinical pharmacokinetics and pharmacodynamics of dapagliflozin, a selective inhibitor of sodium-glucose co-transporter type 2. Clin Pharmacokinet. 2014 Jan;53(1):17-27.
57 The clinical pharmacokinetics of darifenacin. Clin Pharmacokinet. 2006;45(4):325-50.
58 Functional analysis of CYP2D6.31 variant: homology modeling suggests possible disruption of redox partner interaction by Arg440His substitution. Proteins. 2005 May 1;59(2):339-46.
59 Inhibition of human cytochrome P450 isoforms by nonnucleoside reverse transcriptase inhibitors. J Clin Pharmacol. 2001 Jan;41(1):85-91.
60 Dose-dependent inhibition of CYP1A2, CYP2C19 and CYP2D6 by citalopram, fluoxetine, fluvoxamine and paroxetine. Eur J Clin Pharmacol. 1996;51(1):73-8.
61 Effect of the CYP2D6*10 genotype on venlafaxine pharmacokinetics in healthy adult volunteers. Br J Clin Pharmacol. 1999 Apr;47(4):450-3.
62 FDA Label of Deutetrabenazine. The 2020 official website of the U.S. Food and Drug Administration.
63 Different effects of inhibitors on the O- and N-demethylation of codeine in human liver microsomes. Eur J Clin Pharmacol. 1997;52(1):41-7.
64 Drug interactions with calcium channel blockers: possible involvement of metabolite-intermediate complexation with CYP3A. Drug Metab Dispos. 2000 Feb;28(2):125-30.
65 Identification of human cytochrome p450 isozymes involved in diphenhydramine N-demethylation. Drug Metab Dispos. 2007 Jan;35(1):72-8.
66 Reappraisal of the role of dolasetron in prevention and treatment of nausea and vomiting associated with surgery or chemotherapy. Cancer Manag Res. 2012;4:67-73.
67 Characterization of human cytochrome P450 enzymes catalyzing domperidone N-dealkylation and hydroxylation in vitro. Br J Clin Pharmacol. 2004 Sep;58(3):277-87.
68 Donepezil plasma concentrations, CYP2D6 and CYP3A4 phenotypes, and cognitive outcome in Alzheimer's disease. Eur J Clin Pharmacol. 2016 Jun;72(6):711-7.
69 Pharmacogenetics of schizophrenia. Am J Med Genet. 2000 Spring;97(1):98-106.
70 Priapism induced by boceprevir-CYP3A4 inhibition and alpha-adrenergic blockade: case report. Clin Infect Dis. 2014 Jan;58(1):e35-8.
71 Doxepin inhibits CYP2D6 activity in vivo. Pol J Pharmacol. 2004 Jul-Aug;56(4):491-4.
72 Inhibitory effects of anticancer drugs on dextromethorphan-O-demethylase activity in human liver microsomes. Cancer Chemother Pharmacol. 1993;32(6):491-5.
73 Effect of dronedarone on the pharmacokinetics of carvedilol following oral administration to rats. Eur J Pharm Sci. 2018 Jan 1;111:13-19.
74 Duloxetine: clinical pharmacokinetics and drug interactions. Clin Pharmacokinet. 2011 May;50(5):281-94.
75 Eletriptan metabolism by human hepatic CYP450 enzymes and transport by human P-glycoprotein. Drug Metab Dispos. 2003 Jul;31(7):861-9.
76 Eliglustat: first global approval. Drugs. 2014 Oct;74(15):1829-36.
77 Metabolism of ipecac alkaloids cephaeline and emetine by human hepatic microsomal cytochrome P450s, and their inhibitory effects on P450 enzyme activities. Biol Pharm Bull. 2001 Jun;24(6):678-82.
78 Metabolism of epinastine, a histamine H1 receptor antagonist, in human liver microsomes in comparison with that of terfenadine. Res Commun Mol Pathol Pharmacol. 1997 Dec;98(3):273-92.
79 Clinical pharmacokinetics of tyrosine kinase inhibitors. Cancer Treat Rev. 2009 Dec;35(8):692-706.
80 CYP2D6 P34S Polymorphism and Outcomes of Escitalopram Treatment in Koreans with Major Depression. Psychiatry Investig. 2013 Sep;10(3):286-93.
81 Effects of the moderate CYP3A4 inhibitor, fluconazole, on the pharmacokinetics of fesoterodine in healthy subjects. Br J Clin Pharmacol. 2011 Aug;72(2):263-9.
82 Flecainide: current status and perspectives in arrhythmia management. World J Cardiol. 2015 Feb 26;7(2):76-85.
83 (R)-, (S)-, and racemic fluoxetine N-demethylation by human cytochrome P450 enzymes. Drug Metab Dispos. 2000 Oct;28(10):1187-91.
84 Clinical pharmacokinetics of fluvastatin. Clin Pharmacokinet. 2001;40(4):263-81.
85 The potent mechanism-based inactivation of CYP2D6 and CYP3A4 with fusidic acid in in vivo bioaccumulation. Xenobiotica. 2018 Oct;48(10):999-1005.
86 Clinical pharmacokinetics of galantamine. Clin Pharmacokinet. 2003;42(15):1383-92.
87 Pharmacokinetic drug interactions of gefitinib with rifampicin, itraconazole and metoprolol. Clin Pharmacokinet. 2005;44(10):1067-81.
88 Granisetron: new insights into its use for the treatment of chemotherapy-induced nausea and vomiting. Expert Opin Pharmacother. 2003 Sep;4(9):1563-71.
89 The effect of CYP2D6 drug-drug interactions on hydrocodone effectiveness. Acad Emerg Med. 2014 Aug;21(8):879-85.
90 Engineering of cytochrome P450 3A4 for enhanced peroxide-mediated substrate oxidation using directed evolution and site-directed mutagenesis. Drug Metab Dispos. 2006 Dec;34(12):1958-65.
91 Effect of cytochrome P450 2D1 inhibition on hydrocodone metabolism and its behavioral consequences in rats. J Pharmacol Exp Ther. 1997 Mar;280(3):1374-82.
92 Absorption, metabolism, and excretion of oral 14C radiolabeled ibrutinib: an open-label, phase I, single-dose study in healthy men. Drug Metab Dispos. 2015 Feb;43(2):289-97.
93 In vitro evaluation of cytochrome P450-mediated drug interactions between cytarabine, idarubicin, itraconazole and caspofungin. Hematology. 2004 Jun;9(3):217-21.
94 Influences of CYP2D6*10 polymorphisms on the pharmacokinetics of iloperidone and its metabolites in Chinese patients with schizophrenia: a population pharmacokinetic analysis. Acta Pharmacol Sin. 2016 Nov;37(11):1499-1508.
95 QTc prolongation associated with combination therapy of levofloxacin, imipramine, and fluoxetine. Ann Pharmacother. 2005 Mar;39(3):543-6.
96 The combination of umeclidinium bromide and vilanterol in the management of chronic obstructive pulmonary disease: current evidence and future prospects. Ther Adv Respir Dis. 2013 Dec;7(6):311-9.
97 Inhibition of desipramine hydroxylation (Cytochrome P450-2D6) in vitro by quinidine and by viral protease inhibitors: relation to drug interactions in vivo. J Pharm Sci. 1998 Oct;87(10):1184-9.
98 Medical Toxicology of Drug Abuse: Synthesized Chemicals and Psychoactive Plants. doi: 10.1002/9781118105955.ch13
99 Effects of rifampin on the pharmacokinetics of a single dose of istradefylline in healthy subjects. J Clin Pharmacol. 2018 Feb;58(2):193-201.
100 Comparison of verapamil, diltiazem, and labetalol on the bioavailability and metabolism of imipramine. J Clin Pharmacol. 1992 Feb;32(2):176-83.
101 Multiple cytochrome P450 enzymes responsible for the oxidative metabolism of the substituted (S)-3-phenylpiperidine, (S,S)-3-[3-(methylsulfonyl)phenyl]-1-propylpiperidine hydrochloride, in human liver microsomes. Drug Metab Dispos. 2002 Dec;30(12):1372-7.
102 Influence of the CYP2D6 isoenzyme in patients treated with venlafaxine for major depressive disorder: clinical and economic consequences. PLoS One. 2014 Nov 4;9(11):e90453.
103 Involvement of CYP1A2 and CYP3A4 in lidocaine N-deethylation and 3-hydroxylation in humans. Drug Metab Dispos. 2000 Aug;28(8):959-65.
104 Preclinical pharmacokinetics, pharmacology and toxicology of lisdexamfetamine: a novel d-amphetamine pro-drug. Neuropharmacology. 2014 Dec;87:41-50.
105 Stable expression of human cytochrome P450 3A4 in V79 cells and its application for metabolic profiling of ergot derivatives. Eur J Pharmacol. 1995 Oct 6;293(3):183-90.
106 Advisory committee lofexidine hydrochloride (lucemyratm) briefing document.
107 Identification of cytochrome P450 isoforms involved in the metabolism of loperamide in human liver microsomes. Eur J Clin Pharmacol. 2004 Oct;60(8):575-81.
108 In vitro characterization of the inhibition profile of loratadine, desloratadine, and 3-OH-desloratadine for five human cytochrome P-450 enzymes. Drug Metab Dispos. 2001 Sep;29(9):1173-5.
109 Identification of human cytochrome P450 and flavin-containing monooxygenase enzymes involved in the metabolism of lorcaserin, a novel selective human 5-hydroxytryptamine 2C agonist. Drug Metab Dispos. 2012 Apr;40(4):761-71.
110 In vitro identification of the human cytochrome p450 enzymes involved in the oxidative metabolism of loxapine. Biopharm Drug Dispos. 2011 Oct;32(7):398-407.
111 Is therapeutic drug monitoring a case for optimizing clinical outcome and avoiding interactions of the selective serotonin reuptake inhibitors? Ther Drug Monit. 2000 Apr;22(2):143-54.
112 Cytochrome P450 enzymes contributing to demethylation of maprotiline in man. Pharmacol Toxicol. 2002 Mar;90(3):144-9.
113 Meclizine metabolism and pharmacokinetics: formulation on its absorption. J Clin Pharmacol. 2012 Sep;52(9):1343-9.
114 CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes. Drug Metab Dispos. 2004 Sep;32(9):930-6.
115 Ethnic differences in genetic polymorphisms of CYP2D6, CYP2C19, CYP3As and MDR1/ABCB1. Drug Metab Pharmacokinet. 2004 Apr;19(2):83-95.
116 Oxidation of histamine H1 antagonist mequitazine is catalyzed by cytochrome P450 2D6 in human liver microsomes. J Pharmacol Exp Ther. 1998 Feb;284(2):437-42.
117 Thioridazine steady-state plasma concentrations are influenced by tobacco smoking and CYP2D6, but not by the CYP2C9 genotype. Eur J Clin Pharmacol. 2003 May;59(1):45-50.
118 Methadone metabolism and drug-drug interactions: in vitro and in vivo literature review. J Pharm Sci. 2018 Dec;107(12):2983-2991.
119 Cytochrome P450 2D6.1 and cytochrome P450 2D6.10 differ in catalytic activity for multiple substrates. Pharmacogenetics. 2001 Aug;11(6):477-87.
120 Identification of cytochrome P450 2E1 as the predominant enzyme catalyzing human liver microsomal defluorination of sevoflurane, isoflurane, and methoxyflurane. Anesthesiology. 1993 Oct;79(4):795-807.
121 Lack of interaction between amiodarone and mexiletine in cardiac arrhythmia patients. J Clin Pharmacol. 2002 Mar;42(3):342-6.
122 Drugs and steatohepatitis. Semin Liver Dis. 2002;22(2):185-94.
123 Metoclopramide is metabolized by CYP2D6 and is a reversible inhibitor, but not inactivator, of CYP2D6. Xenobiotica. 2014 Apr;44(4):309-319.
124 The impact of CYP2D6 mediated drug-drug interaction: a systematic review on a combination of metoprolol and paroxetine/fluoxetine. Br J Clin Pharmacol. 2018 Dec;84(12):2704-2715.
125 Impact of CYP2D6*10 on mexiletine pharmacokinetics in healthy adult volunteers. Eur J Clin Pharmacol. 2003 Sep;59(5-6):395-9.
126 Assessment of CYP2D6 activity as a form of optimizing antidepressant therapy. Psychiatr Pol. 2004 Nov-Dec;38(6):1093-104.
127 Akathisia with combined use of midodrine and promethazine. JAMA. 2006 May 3;295(17):2000-1. Letter
128 Comparative molecular field analysis and QSAR on substrates binding to cytochrome p450 2D6. Bioorg Med Chem. 2003 Dec 1;11(24):5545-54.
129 Role of cytochrome p450 isoenzymes 3A and 2D6 in the in vivo metabolism of mirabegron, a beta-3-adrenoceptor agonist. Clin Drug Investig. 2013 Jun;33(6):429-40.
130 A review of the pharmacological and clinical profile of mirtazapine. CNS Drug Rev. 2001 Fall;7(3):249-64.
131 Moclobemide, a substrate of CYP2C19 and an inhibitor of CYP2C19, CYP2D6, and CYP1A2: a panel study. Clin Pharmacol Ther. 1995 Jun;57(6):670-7.
132 Activation of G-proteins by morphine and codeine congeners: insights to the relevance of O- and N-demethylated metabolites at mu- and delta-opioid receptors. J Pharmacol Exp Ther. 2004 Feb;308(2):547-54.
133 Influence of CYP2C9 and CYP2D6 polymorphisms on the pharmacokinetics of nateglinide in genotyped healthy volunteers. Clin Pharmacokinet. 2004;43(4):267-78.
134 Nebivolol: a review of its clinical and pharmacological characteristics. Int J Clin Pharmacol Ther. 2006 Aug;44(8):344-57.
135 Nefazodone, meta-chlorophenylpiperazine, and their metabolites in vitro: cytochromes mediating transformation, and P450-3A4 inhibitory actions. Psychopharmacology (Berl). 1999 Jul;145(1):113-22.
136 Characterization of the in vitro biotransformation of the HIV-1 reverse transcriptase inhibitor nevirapine by human hepatic cytochromes P-450. Drug Metab Dispos. 1999 Dec;27(12):1488-95.
137 Inhibitory effects of nicardipine to cytochrome P450 (CYP) in human liver microsomes. Biol Pharm Bull. 2005 May;28(5):882-5.
138 Involvement of CYP2D6 but not CYP2C19 in nicergoline metabolism in humans. Br J Clin Pharmacol. 1996 Dec;42(6):707-11.
139 Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes. Arch Toxicol. 1999 Mar;73(2):65-70.
140 Molecular basis of polymorphic drug metabolism. J Mol Med (Berl). 1995 Nov;73(11):539-53.
141 Nefazodone pharmacokinetics in depressed children and adolescents. J Am Acad Child Adolesc Psychiatry. 2000 Aug;39(8):1008-16.
142 A study on CYP2C19 and CYP2D6 polymorphic effects on pharmacokinetics and pharmacodynamics of amitriptyline in healthy Koreans. Clin Transl Sci. 2017 Mar;10(2):93-101.
143 [Olanzapine: pharmacology, pharmacokinetics and therapeutic drug monitoring]. Fortschr Neurol Psychiatr. 2001 Nov;69(11):510-7.
144 First clinical experience with TRV130: pharmacokinetics and pharmacodynamics in healthy volunteers. J Clin Pharmacol. 2014 Mar;54(3):351-7.
145 Cytochrome P450 2D6 metabolism and 5-hydroxytryptamine type 3 receptor antagonists for postoperative nausea and vomiting. Med Sci Monit. 2005 Oct;11(10):RA322-8.
146 Brexpiprazole: first global approval. Drugs. 2015 Sep;75(14):1687-97.
147 Inhibitory effects of antiparasitic drugs on cytochrome P450 2D6. Eur J Clin Pharmacol. 1995;48(1):35-8.
148 Identification of human P450 isoforms involved in the metabolism of the antiallergic drug, oxatomide, and its kinetic parameters and inhibition constants. Biol Pharm Bull. 2005 Feb;28(2):328-34.
149 Exposure to oral oxycodone is increased by concomitant inhibition of CYP2D6 and 3A4 pathways, but not by inhibition of CYP2D6 alone. Br J Clin Pharmacol. 2010 Jul;70(1):78-87.
150 Interpreting serum risperidone concentrations. Pharmacotherapy. 2005 Feb;25(2):299-302.
151 Clinical pharmacogenetics implementation consortium (CPIC) guideline for CYP2D6 and CYP2C19 genotypes and dosing of selective serotonin reuptake inhibitors. Clin Pharmacol Ther. 2015 Aug;98(2):127-34.
152 Pazopanib: the newest tyrosine kinase inhibitor for the treatment of advanced or metastatic renal cell carcinoma. Drugs. 2011 Mar 5;71(4):443-54.
153 Identification of human cytochrome P(450)s that metabolise anti-parasitic drugs and predictions of in vivo drug hepatic clearance from in vitro data. Eur J Clin Pharmacol. 2003 Sep;59(5-6):429-42.
154 Cytochrome P-450 enzymes and FMO3 contribute to the disposition of the antipsychotic drug perazine in vitro. Psychopharmacology (Berl). 2000 Sep;151(4):312-20.
155 CYP2B6, CYP2D6, and CYP3A4 catalyze the primary oxidative metabolism of perhexiline enantiomers by human liver microsomes. Drug Metab Dispos. 2007 Jan;35(1):128-38.
156 Steady-state pharmacokinetics of a new antipsychotic agent perospirone and its active metabolite, and its relationship with prolactin response. Ther Drug Monit. 2004 Aug;26(4):361-5.
157 The influence of the CYP3A4*22 polymorphism and CYP2D6 polymorphisms on serum concentrations of aripiprazole, haloperidol, pimozide, and risperidone in psychiatric patients. J Clin Psychopharmacol. 2015 Jun;35(3):228-36.
158 Chemistry, pharmacology, toxicology, and hepatic metabolism of designer drugs of the amphetamine (ecstasy), piperazine, and pyrrolidinophenone types: a synopsis. Ther Drug Monit. 2004 Apr;26(2):127-31.
159 Polymorphism of human cytochrome P450 2D6 and its clinical significance: part II. Clin Pharmacokinet. 2009;48(12):761-804.
160 Novel pathways of ponatinib disposition catalyzed by CYP1A1 involving generation of potentially toxic metabolites. J Pharmacol Exp Ther. 2017 Oct;363(1):12-19.
161 Involvement of CYP2D6 activity in the N-oxidation of procainamide in man. Pharmacogenetics. 1999 Dec;9(6):683-96.
162 Potential for drug interactions involving cytochromes P450 2D6 and 3A4 on general adult psychiatric and functional elderly psychiatric wards. Br J Clin Pharmacol. 2004 Apr;57(4):464-72.
163 Effect of genetic polymorphism on the metabolism of endogenous neuroactive substances, progesterone and p-tyramine, catalyzed by CYP2D6. Brain Res Mol Brain Res. 2004 Oct 22;129(1-2):117-23.
164 Effect of selective serotonin reuptake inhibitors on the oxidative metabolism of propafenone: in vitro studies using human liver microsomes. J Clin Psychopharmacol. 2000 Aug;20(4):428-34.
165 Effects of propofol on human hepatic microsomal cytochrome P450 activities. Xenobiotica. 1998 Sep;28(9):845-53.
166 Structure-activity relationship for human cytochrome P450 substrates and inhibitors. Drug Metab Rev. 2002 Feb-May;34(1-2):69-82.
167 A liquid chromatographic-electrospray-tandem mass spectrometric method for quantitation of quetiapine in human plasma and liver microsomes: application to study in vitro metabolism. J Anal Toxicol. 2004 Sep;28(6):443-8.
168 Binding of quinidine radically increases the stability and decreases the flexibility of the cytochrome P450 2D6 active site. J Inorg Biochem. 2012 May;110:46-50.
169 Inhibition of cytochrome P450 2D6: structure-activity studies using a series of quinidine and quinine analogues. Chem Res Toxicol. 2003 Apr;16(4):450-9.
170 Oxidation of ranitidine by isozymes of flavin-containing monooxygenase and cytochrome P450. Jpn J Pharmacol. 2000 Oct;84(2):213-20.
171 Ranolazine: a contemporary review. J Am Heart Assoc. 2016 Mar 15;5(3):e003196.
172 A 28-day, randomized, double-blind, placebo-controlled, parallel group study of nebulized revefenacin in patients with chronic obstructive pulmonary disease. Respir Res. 2017 Nov 2;18(1):182.
173 Xenobiotic-metabolizing cytochromes p450 in human white adipose tissue: expression and induction. Drug Metab Dispos. 2010 Apr;38(4):679-86.
174 Cytochrome P450 3A inhibitor itraconazole affects plasma concentrations of risperidone and 9-hydroxyrisperidone in schizophrenic patients. Clin Pharmacol Ther. 2005 Nov;78(5):520-8.
175 Reversible coma caused by risperidone-ritonavir interaction. Clin Neuropharmacol. 2002 Sep-Oct;25(5):251-3.
176 Inter- and intraindividual pharmacokinetic variations in the treatment of Parkinson's disease. Rinsho Shinkeigaku. 2005 Nov;45(11):895-8.
177 Some aspects of genetic polymorphism in the biotransformation of antidepressants. Therapie. 2004 Jan-Feb;59(1):5-12.
178 Genetic polymorphisms in cytochrome P450 enzymes: effect on efficacy and tolerability of HMG-CoA reductase inhibitors. Am J Cardiovasc Drugs. 2004;4(4):247-55.
179 Clinical pharmacokinetics and pharmacodynamics of solifenacin. Clin Pharmacokinet. 2009;48(5):281-302.
180 Tafenoquine and its potential in the treatment and relapse prevention of Plasmodium vivax malaria: the evidence to date. Drug Des Devel Ther. 2016 Jul 26;10:2387-99.
181 CYP2D6 polymorphisms and tamoxifen metabolism: clinical relevance. Curr Oncol Rep. 2010 Jan;12(1):7-15.
182 Identification of cytochrome P450 isozymes involved in metabolism of the alpha1-adrenoceptor blocker tamsulosin in human liver microsomes. Xenobiotica. 1998 Oct;28(10):909-22.
183 Investigations into the drug-drug interaction potential of tapentadol in human liver microsomes and fresh human hepatocytes. Drug Metab Lett. 2008 Jan;2(1):67-75.
184 In vitro metabolism of tegaserod in human liver and intestine: assessment of drug interactions. Drug Metab Dispos. 2001 Oct;29(10):1269-76.
185 Role of tetrabenazine for Huntington's disease-associated chorea. Ann Pharmacother. 2010 Jun;44(6):1080-9.
186 Characterization of human cytochromes P450 involved in theophylline 8-hydroxylation. Biochem Pharmacol. 1995 Jul 17;50(2):205-11.
187 Effect of health foods on cytochrome P450-mediated drug metabolism. J Pharm Health Care Sci. 2017 May 10;3:14.
188 Cardiac safety of ophthalmic timolol. Expert Opin Drug Saf. 2016 Nov;15(11):1549-1561.
189 A phenotype-genotype approach to predicting CYP450 and P-glycoprotein drug interactions with the mixed inhibitor/inducer tipranavir/ritonavir. Clin Pharmacol Ther. 2010 Jun;87(6):735-42.
190 Identification of metabolic pathways involved in the biotransformation of tolperisone by human microsomal enzymes. Drug Metab Dispos. 2003 May;31(5):631-6.
191 Effect of the CYP2D6*10 genotype on tolterodine pharmacokinetics. Drug Metab Dispos. 2010 Sep;38(9):1456-63.
192 In vitro characterization of the human biotransformation and CYP reaction phenotype of ET-743 (Yondelis, Trabectidin), a novel marine anti-cancer drug. Invest New Drugs. 2006 Jan;24(1):3-14.
193 Clinical pharmacology of tramadol. Clin Pharmacokinet. 2004;43(13):879-923.
194 Evaluating the role of drug metabolism and reactive intermediates in trazodone-induced cytotoxicity toward freshly-isolated rat hepatocytes. Drug Res (Stuttg). 2016 Nov;66(11):592-596.
195 FDA Label of Egaten. The 2020 official website of the U.S. Food and Drug Administration.
196 Galactorrhea during treatment with trimipramine. A case report. Pharmacopsychiatry. 2005 Nov;38(6):326-7.
197 Population pharmacokinetics of upadacitinib using the immediate-release and extended-release formulations in healthy subjects and subjects with rheumatoid arthritis: analyses of phase I-III clinical trials. Clin Pharmacokinet. 2019 Aug;58(8):1045-1058.
198 The associations between CYP2D6 metabolizer status and pharmacokinetics and clinical outcomes of venlafaxine: a systematic review and meta-analysis. Pharmacopsychiatry. 2019 Sep;52(5):222-231.
199 Vilazodone HCl (Viibryd): A Serotonin Partial Agonist and Reuptake Inhibitor For the Treatment of Major Depressive Disorder. P T. 2012 Jan;37(1):28-31.
200 Characterization of human cytochrome P450 isoenzymes involved in the metabolism of vinorelbine. Fundam Clin Pharmacol. 2005 Oct;19(5):545-53.
201 Identification of the cytochrome P450 and other enzymes involved in the in vitro oxidative metabolism of a novel antidepressant, Lu AA21004. Drug Metab Dispos. 2012 Jul;40(7):1357-65.
202 Relationship of cytochrome P450 pharmacogenetics to the effects of yohimbine on gastrointestinal transit and catecholamines in healthy subjects. Neurogastroenterol Motil. 2008 Aug;20(8):891-9.
203 Protease inhibitors in patients with HIV disease. Clinically important pharmacokinetic considerations. Clin Pharmacokinet. 1997 Mar;32(3):194-209.
204 Effect of zolpidem on human cytochrome P450 activity, and on transport mediated by P-glycoprotein. Biopharm Drug Dispos. 2002 Dec;23(9):361-7.
205 Identification of cytochrome P450 enzymes involved in the metabolism of zotepine, an antipsychotic drug, in human liver microsomes. Xenobiotica. 1999 Mar;29(3):217-29.
206 Genotype and co-medication dependent CYP2D6 metabolic activity: effects on serum concentrations of aripiprazole, haloperidol, risperidone, paliperidone and zuclopenthixol. Eur J Clin Pharmacol. 2016 Feb;72(2):175-84.
207 Contribution of human hepatic cytochrome P450s and steroidogenic CYP17 to the N-demethylation of aminopyrine. Xenobiotica. 1999 Feb;29(2):187-93.
208 Stereoselective metabolism of cibenzoline, an antiarrhythmic drug, by human and rat liver microsomes: possible involvement of CYP2D and CYP3A. Drug Metab Dispos. 2000 Sep;28(9):1128-34.
209 Dapoxetine: a new option in the medical management of premature ejaculation. Ther Adv Urol. 2012 Oct;4(5):233-51.
210 The role of active metabolites in dihydrocodeine effects. Int J Clin Pharmacol Ther. 2003 Mar;41(3):95-106.
211 Residual effects of esmirtazapine on actual driving performance: overall findings and an exploratory analysis into the role of CYP2D6 phenotype. Psychopharmacology (Berl). 2011 May;215(2):321-32.
212 In vitro metabolism of TAK-438, vonoprazan fumarate, a novel potassium-competitive acid blocker. Xenobiotica. 2017 Dec;47(12):1027-1034.
213 The metabolic profile of azimilide in man: in vivo and in vitro evaluations. J Pharm Sci. 2005 Sep;94(9):2084-95.
214 In vitro metabolism of the analgesic bicifadine in the mouse, rat, monkey, and human. Drug Metab Dispos. 2007 Dec;35(12):2232-41.
215 Interpretation of opiate urine drug screens.
216 An updated review of iclaprim: a potent and rapidly bactericidal antibiotic for the treatment of skin and skin structure infections and nosocomial pneumonia caused by gram-positive including multidrug-resistant bacteria. Open Forum Infect Dis. 2018 Jan 6;5(2):ofy003.
217 Evaluation of in vitro drug interactions with karenitecin, a novel, highly lipophilic camptothecin derivative in phase II clinical development. J Clin Pharmacol. 2003 Sep;43(9):1008-14.
218 Idalopirdine as a treatment for Alzheimer's disease. Expert Opin Investig Drugs. 2015;24(7):981-7.
219 Involvement of multiple cytochrome P450 and UDP-glucuronosyltransferase enzymes in the in vitro metabolism of muraglitazar. Drug Metab Dispos. 2007 Jan;35(1):139-49.
220 Tardive dyskinesia: placing vesicular monoamine transporter type 2 (VMAT2) inhibitors into clinical perspective. Expert Rev Neurother. 2018 Apr;18(4):323-332.
221 Effect of netupitant, a highly selective NK?receptor antagonist, on the pharmacokinetics of palonosetron and impact of the fixed dose combination of netupitant and palonosetron when coadministered with ketoconazole, rifampicin, and oral contraceptives. Support Care Cancer. 2013 Oct;21(10):2879-87.
222 Tiotropium rromide/olodaterol (Stiolto Respimat): once-daily combination therapy for the maintenance of COPD. P T. 2016 Feb;41(2):97-102.
223 Pharmacokinetics of novel atrial-selective antiarrhythmic agent vernakalant hydrochloride injection (RSD1235): influence of CYP2D6 expression and other factors. J Clin Pharmacol. 2009 Jan;49(1):17-29.
224 Fexinidazole--a new oral nitroimidazole drug candidate entering clinical development for the treatment of sleeping sickness. PLoS Negl Trop Dis. 2010 Dec 21;4(12):e923.
225 Novel binding mode of the acidic CYP2D6 substrates pactimibe and its metabolite R-125528. Drug Metab Dispos. 2008 Sep;36(9):1938-43.
226 Involvement of human cytochrome P450 2D6 in the bioactivation of acetaminophen. Drug Metab Dispos. 2000 Dec;28(12):1397-400.
227 Asunaprevir: a review of preclinical and clinical pharmacokinetics and drug-drug interactions. Clin Pharmacokinet. 2015 Dec;54(12):1205-22.
228 In vitro metabolism of CP-122,721 ((2S,3S)-2-phenyl-3-[(5-trifluoromethoxy-2-methoxy)benzylamino]piperidine), a non-peptide antagonist of the substance P receptor. Drug Metab Pharmacokinet. 2007 Oct;22(5):336-49.
229 In vitro metabolism of ferroquine (SSR97193) in animal and human hepatic models and antimalarial activity of major metabolites on Plasmodium falciparum. Drug Metab Dispos. 2006 Apr;34(4):667-82.
230 Cytochrome P450 2D catalyze steroid 21-hydroxylation in the brain. Endocrinology. 2004 Feb;145(2):699-705.
231 Disposition and metabolism of LY2603618, a Chk-1 inhibitor following intravenous administration in patients with advanced and/or metastatic solid tumors. Xenobiotica. 2014 Sep;44(9):827-41.
232 Pharmacokinetics of N-propylajmaline in relation to polymorphic sparteine oxidation. Klin Wochenschr. 1985 Nov 15;63(22):1180-6.
233 Cytochrome P450 enzymes involved in the metabolic pathway of the histamine 2 (H2)-receptor antagonist roxatidine acetate by human liver microsomes. Arzneimittelforschung. 2001;51(8):651-8.
234 Differential cytochrome P450 2D metabolism alters tafenoquine pharmacokinetics. Antimicrob Agents Chemother. 2015 Jul;59(7):3864-9.
235 Interspecies pharmacokinetics and in vitro metabolism of SQ109. Br J Pharmacol. 2006 Mar;147(5):476-85.
236 Nonclinical pharmacokinetics and in vitro metabolism of H3B-6545, a novel selective ERalpha covalent antagonist (SERCA). Cancer Chemother Pharmacol. 2019 Jan;83(1):151-160.
237 Metabolism and disposition of hepatitis C polymerase inhibitor dasabuvir in humans. Drug Metab Dispos. 2016 Aug;44(8):1139-47.
238 ITX 5061 quantitation in human plasma with reverse phase liquid chromatography and mass spectrometry detection. Antivir Ther. 2013;18(3):329-36.
239 Tricyclic antidepressant pharmacology and therapeutic drug interactions updated. Br J Pharmacol. 2007 Jul;151(6):737-48.
240 Evaluation of the transport, in vitro metabolism and pharmacokinetics of Salvinorin A, a potent hallucinogen. Eur J Pharm Biopharm. 2009 Jun;72(2):471-7.
241 Involvement of multiple human cytochromes P450 in the liver microsomal metabolism of astemizole and a comparison with terfenadine. Br J Clin Pharmacol. 2001 Feb;51(2):133-42.
242 Metabolism of dexfenfluramine in human liver microsomes and by recombinant enzymes: role of CYP2D6 and 1A2. Pharmacogenetics. 1998 Oct;8(5):423-32.
243 Effects of the antifungal agents on oxidative drug metabolism: clinical relevance. Clin Pharmacokinet. 2000 Feb;38(2):111-80.
244 Human cytochromes P450 mediating phenacetin O-deethylation in vitro: validation of the high affinity component as an index of CYP1A2 activity. J Pharm Sci. 1998 Dec;87(12):1502-7.
245 Metabolic drug interactions with newer antipsychotics: a comparative review. Basic Clin Pharmacol Toxicol. 2007 Jan;100(1):4-22.
246 Identification of cytochrome P450 enzymes involved in the metabolism of 4'-methoxy-alpha-pyrrolidinopropiophenone (MOPPP), a designer drug, in human liver microsomes. Xenobiotica. 2003 Oct;33(10):989-98.
247 Pharmacokinetics of sabeluzole and dextromethorphan oxidation capacity in patients with severe hepatic dysfunction and healthy volunteers. Br J Clin Pharmacol. 2001 Feb;51(2):164-8.
248 Dopamine formation from tyramine by CYP2D6. Biochem Biophys Res Commun. 1998 Aug 28;249(3):838-43.
249 In vitro evaluation of potential in vivo probes for human flavin-containing monooxygenase (FMO): metabolism of benzydamine and caffeine by FMO and P450 isoforms. Br J Clin Pharmacol. 2000 Oct;50(4):311-4.
250 Pharmacokinetic assessment of the sites of first-pass metabolism of BMS-181101, an antidepressant agent, in rats. J Pharm Pharmacol. 1998 Mar;50(3):275-8.
251 Role of cytochrome P4502D6 in the metabolism of brofaromine. A new selective MAO-A inhibitor. Eur J Clin Pharmacol. 1993;45(3):265-9.
252 Metabolism of ezlopitant, a nonpeptidic substance P receptor antagonist, in liver microsomes: enzyme kinetics, cytochrome P450 isoform identity, and in vitro-in vivo correlation. Drug Metab Dispos. 2000 Sep;28(9):1069-76.
253 Proof of a 1-(3-chlorophenyl)piperazine (mCPP) intake: use as adulterant of cocaine resulting in drug-drug interactions? J Chromatogr B Analyt Technol Biomed Life Sci. 2007 Aug 15;855(2):127-33.
254 Antidepressants: Past, Present and Future. Edited by Sheldon H. Preskorn Christina Y. Stanga John P. Feighner Ruth Ross. Page: 574.
255 N,N-diethyl-2-[4-(phenylmethyl)phenoxy] ethanamine (DPPE) a chemopotentiating and cytoprotective agent in clinical trials: interaction with histamine at cytochrome P450 3A4 and other isozymes that metabolize antineoplastic drugs. Cancer Chemother Pharmacol. 2000;45(4):298-304.
256 The biotransformation of clomipramine in vitro, identification of the cytochrome P450s responsible for the separate metabolic pathways. J Pharmacol Exp Ther. 1996 Jun;277(3):1659-64.
257 Metabolism and disposition of prescription opioids: a review. Forensic Sci Rev. 2015 Jul;27(2):115-45.
258 Metabolism of the newest antidepressants: comparisons with related predecessors. IDrugs. 2004 Feb;7(2):143-50.
259 Psychedelic 5-methoxy-N,N-dimethyltryptamine: metabolism, pharmacokinetics, drug interactions, and pharmacological actions. Curr Drug Metab. 2010 Oct;11(8):659-66.
260 Interactions of amphetamine analogs with human liver CYP2D6. Biochem Pharmacol. 1997 Jun 1;53(11):1605-12.
261 Cytochrome b5 is a major determinant of human cytochrome P450 CYP2D6 and CYP3A4 activity in vivo. Mol Pharmacol. 2015 Apr;87(4):733-9.
262 Studies on the metabolism of the fentanyl-derived designer drug butyrfentanyl in human in vitro liver preparations and authentic human samples using liquid chromatography-high resolution mass spectrometry (LC-HRMS). Drug Test Anal. 2017 Jul;9(7):1085-1092.
263 A sensitive LC-MS/MS assay for the determination of dextromethorphan and metabolites in human urine--application for drug interaction studies assessing potential CYP3A and CYP2D6 inhibition. J Pharm Biomed Anal. 2002 Aug 22;30(1):113-24.
264 [Trazodon--the antidepressant: mechanism of action and its position in the treatment of depression]. Psychiatr Pol. 2011 Jul-Aug;45(4):611-25.
265 Metabolism of methoxyphenamine and 2-methoxyamphetamine in P4502D6-transfected cells and cell preparations. Xenobiotica. 1995 Sep;25(9):895-906.
266 Human pharmacology of MDMA: pharmacokinetics, metabolism, and disposition. Ther Drug Monit. 2004 Apr;26(2):137-44.
267 Identification of the human hepatic cytochromes P450 involved in the in vitro oxidation of antipyrine. Drug Metab Dispos. 1996 Apr;24(4):487-94.
268 Evaluation of interethnic differences in repinotan pharmacokinetics by using population approach. Drug Metab Pharmacokinet. 2006 Feb;21(1):61-9.