Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMR1NMD)

• Drug Name: Nimesulide Drug Info
• Synonyms: nimesulide; 51803-78-2; N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide; Mesulid; Flogovital; Sulidene; Nimed; R-805; 4-NITRO-2-PHENOXYMETHANESULFONANILIDE; Nisulid; Nimesulidum [INN-Latin]; Nimesulida [INN-Spanish]; R 805; UNII-V4TKW1454M; 4-Nitro-2-phenoxy-methanesulfonanilide; 4'-Nitro-2'-phenoxymethanesulfonanilide; Methanesulfonamide, N-(4-nitro-2-phenoxyphenyl)-; EINECS 257-431-4; 4'-Nitro-2'-phenoxymethansulfonanilid; BRN 2421175; CHEMBL56367; MLS000069680; V4TKW1454M; Methanesulfonanilide, 4'-nitro-2'-phenoxy-; CHEBI:44445; Dulanermin

Indication

Disease Entry	ICD 11	Status	REF
Metastatic colorectal cancer	2B91	Terminated	[1]
Non-hodgkin lymphoma	2B33.5	Terminated	[1]
Non-small-cell lung cancer	2C25.Y	Terminated	[1]

• Cross-matching ID:
  PubChem CID: 4495
  ChEBI ID: CHEBI:44445
  CAS Number: CAS 51803-78-2
  TTD Drug ID: DMR1NMD
  INTEDE Drug ID: DR1160

Molecule-Related Drug Atlas

Drug(s) Targeting TNF related apoptosis inducing ligand (TNFSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ad5-TRAIL	DM2UMGE	Prostate cancer	2C82.0	Phase 1	[14]
DA-3607	DM4JG0B	Brain cancer	2A00	Phase 1	[15]
ABBV-621	DM90EO3	Haematological malignancy	2B33.Y	Phase 1	[16]

Drug(s) Targeting Prostaglandin G/H synthase 2 (COX-2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[17]
Naproxen	DMZ5RGV	Bursitis		Approved	[18]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[19]
Indomethacin	DMSC4A7	Bursitis		Approved	[3]
Celecoxib	DM6LOQU	Dysmenorrhea	GA34.3	Approved	[20]
Nabumetone	DMAT2XH	Osteoarthritis	FA00-FA05	Approved	[21]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[22]
Flurbiprofen	DMGN4BY	Osteoarthritis	FA00-FA05	Approved	[23]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[24]
Aminosalicylic Acid	DMENSL5	Crohn disease	DD70	Approved	[3]

Drug(s) Targeting Lactotransferrin (LTF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Parecoxib	DMIV8CT	N. A.	N. A.	Phase 4	[25]
Talactoferrin	DMV7T64	Diabetic foot ulcer	BD54	Phase 3	[26]
HLF 1-11	DMDFG1O	Bacteremia	1A73	Phase 1/2	[27]
Alpha-D-Mannose	DMF5DLW	Discovery agent	N.A.	Investigative	[28]
Fucose	DMAHMSV	N. A.	N. A.	Investigative	[28]
Lauric Acid	DM9C8KQ	Discovery agent	N.A.	Investigative	[28]
Alpha-D-Fucose	DM6VH7A	Discovery agent	N.A.	Investigative	[28]
Nitrilotriacetic Acid	DMIOQFU	Discovery agent	N.A.	Investigative	[28]
3h-Indole-5,6-Diol	DMBFCTZ	Discovery agent	N.A.	Investigative	[28]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[29]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[30]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[31]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[32]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[33]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[34]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[35]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[36]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[30]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[37]
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[38]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[39]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[40]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[41]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[42]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[42]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[43]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[44]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[45]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[46]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[48]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[49]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[52]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[53]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[54]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[55]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[56]

Drug(s) Affected By Peroxisome proliferator-activated receptor alpha (PPARA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[59]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[55]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[60]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[61]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[62]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[65]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[66]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[67]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[47]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[68]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[69]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[70]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[7]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[72]

Drug(s) Affected By Prostaglandin G/H synthase 1 (PTGS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[74]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[68]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[75]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[76]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Bupivacaine	DM4PRFC	Anaesthesia	9A78.6	Approved	[79]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[78]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[80]

Drug(s) Affected By Sulfotransferase 1A1 (SULT1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[81]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[82]
Minoxidil	DMA2Z4F	Alopecia	ED70	Approved	[83]
Benzyl alcohol	DMBVYDI	Head and body lice	1G00.0	Approved	[84]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[83]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[85]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[86]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[87]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[88]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]

Drug(s) Affected By Catalase (CAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[91]
Haloperidol	DM96SE0	Delirium		Approved	[92]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[93]
Selenium	DM25CGV	N. A.	N. A.	Approved	[94]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[95]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[96]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[97]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[88]

Drug(s) Affected By Glutathione peroxidase 1 (GPX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[98]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[99]
Amlexanox	DM0DQM5	Respiratory tract inflammation	CA07	Approved	[100]
Selenium	DM25CGV	N. A.	N. A.	Approved	[101]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[102]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[103]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[76]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[104]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[105]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[106]

Drug(s) Affected By Caveolin-1 (CAV1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[107]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[108]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[109]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[110]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[111]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[51]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[113]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[114]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[115]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[116]
Selenium	DM25CGV	N. A.	N. A.	Approved	[117]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[118]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[119]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[120]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[121]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[122]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[123]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[124]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[125]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[126]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[127]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[128]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[129]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[130]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[131]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[132]

Drug(s) Affected By Prostaglandin reductase 1 (PTGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[133]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[88]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[135]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[137]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[138]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]

Drug(s) Affected By Proepiregulin (EREG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[140]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[7]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[7]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[7]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[142]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[88]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[144]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[7]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[145]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[146]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[147]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[148]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[149]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[150]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[151]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[152]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[153]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[154]

Drug(s) Affected By Transmembrane protease serine 2 (TMPRSS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[6]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[6]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Selenium	DM25CGV	N. A.	N. A.	Approved	[155]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[6]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[6]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[6]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[6]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[6]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[6]

Drug(s) Affected By Prothrombin (F2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[156]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[159]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[160]
Phytonadione	DM8HDOL	Bleeding disorder	GA20-GA21	Approved	[161]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[162]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[163]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[164]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[165]
Fructose	DM43AN2	Vomiting	MD90	Approved	[92]
Ketoprofen	DMRKXPT	Bursitis		Approved	[92]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[166]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[167]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[168]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[115]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[169]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[116]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[170]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[171]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[172]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[7]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[7]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[173]
Selenium	DM25CGV	N. A.	N. A.	Approved	[174]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[175]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[176]

Drug(s) Affected By Antileukoproteinase (SLPI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[7]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[7]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[141]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[7]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[7]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[7]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[7]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[7]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[177]
Selenium	DM25CGV	N. A.	N. A.	Approved	[174]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[178]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[179]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[180]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[181]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[182]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[183]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[184]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[185]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[186]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[187]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[188]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[189]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[190]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[191]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[192]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[193]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[194]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[192]

Drug(s) Affected By Hepatocyte growth factor receptor (MET)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cabozantinib	DMIYDT4	Medullary thyroid gland carcinoma		Approved	[195]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[196]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[7]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[7]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[7]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[178]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[88]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[197]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[178]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[198]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[199]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[200]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[148]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[201]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[202]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[201]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[119]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[203]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[204]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[205]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[206]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[207]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[208]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[209]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[171]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[7]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[210]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[7]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[211]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[212]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[213]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[214]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[92]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[198]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[215]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[216]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[167]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[107]

Drug(s) Affected By Aromatase (CYP19A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Letrozole	DMH07Y3	Estrogen-receptor positive breast cancer		Approved	[217]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[218]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[219]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[219]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
FADROZOLE	DM3C5GZ	Breast cancer	2C60-2C65	Approved	[220]
Bifonazole	DM3KN7V	Fungal infection	1F29-1F2F	Approved	[221]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[222]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[219]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[223]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[71]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[224]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[116]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[225]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[226]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[227]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[228]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[229]

Drug(s) Affected By L-selectin (SELL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[230]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[230]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[231]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[232]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[230]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[233]
Nabumetone	DMAT2XH	Osteoarthritis	FA00-FA05	Approved	[230]
Phenylbutazone	DMAYL0T	Chronic pain	MG30	Approved	[230]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]

Drug(s) Affected By Bone morphogenetic protein 6 (BMP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[7]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[7]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[234]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[7]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[7]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[7]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[7]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[235]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[7]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[236]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[237]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[238]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[239]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[167]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[240]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[241]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[242]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[108]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[243]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[244]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[245]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[238]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[246]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[247]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[248]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[237]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[92]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[170]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[167]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[240]

Drug(s) Affected By Multidrug resistance-associated protein 1 (ABCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[249]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[250]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[251]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[252]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[253]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[254]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[255]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[256]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[257]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[257]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[258]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[259]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[260]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[261]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[262]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[263]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[264]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[265]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[266]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[267]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[268]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[269]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[270]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[271]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[272]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[273]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[274]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[275]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[276]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[88]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[277]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[278]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[279]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[146]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[280]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[273]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[149]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[281]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[202]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[282]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[283]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[284]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[281]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[285]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[286]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[287]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[288]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[289]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[290]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[291]

Drug(s) Affected By Presenilin-2 (PSEN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[292]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[293]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[294]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[295]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[296]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[297]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[298]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[299]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[300]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[301]

Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[292]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[302]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[303]
Selenium	DM25CGV	N. A.	N. A.	Approved	[155]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[304]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[305]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[306]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[307]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[308]

Drug(s) Affected By Heat shock factor protein 1 (HSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[309]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[310]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[310]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[311]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[312]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[310]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[310]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[310]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[310]

Drug(s) Affected By Peroxisome proliferator-activated receptor delta (PPARD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[133]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[313]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[314]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[315]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[316]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[317]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[63]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[318]

Drug(s) Affected By Potassium voltage-gated channel subfamily H member 2 (KCNH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metoclopramide	DMFA5MY	Nausea	MD90	Approved	[319]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[320]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[321]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[322]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[322]
Disopyramide	DM5SYZP	Long QT syndrome	BC65.0	Approved	[323]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[324]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[325]
Dofetilide	DMPN1TW	Sinus rhythm disorder	BC9Y	Approved	[326]
Flecainide	DMSQDLE	Tachyarrhythmias	BC71	Approved	[322]

Drug(s) Affected By Interleukin-24 (IL24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[198]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[7]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[171]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[7]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[7]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[203]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[7]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[78]

Drug(s) Affected By Sodium channel protein type 5 subunit alpha (SCN5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Disopyramide	DM5SYZP	Long QT syndrome	BC65.0	Approved	[92]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[327]
Flecainide	DMSQDLE	Tachyarrhythmias	BC71	Approved	[328]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[329]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[330]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[331]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[332]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[333]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[334]
Retigabine	DMGNYIH	Behcet disease	4A62	Approved	[335]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[336]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[337]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[270]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Selenium	DM25CGV	N. A.	N. A.	Approved	[155]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[338]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[339]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[179]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[88]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[340]

Drug(s) Affected By PRKC apoptosis WT1 regulator protein (PAWR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[341]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[342]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[343]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[344]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[345]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[346]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]
Bendamustine hydrochloride	DMFH15Z	leukaemia	2A60-2B33	Approved	[347]

Drug(s) Affected By Perilipin-2 (PLIN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[348]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[349]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[350]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[342]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[135]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[351]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[344]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[352]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[318]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]

Drug(s) Affected By Angiopoietin-related protein 4 (ANGPTL4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[92]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[88]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[353]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[351]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[344]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[351]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[351]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[354]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[318]

Drug(s) Affected By Angiotensin-converting enzyme 2 (ACE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Captopril	DM458UM	Chronic heart failure	BD1Z	Approved	[355]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[6]
Dantrolene	DM1D8XY	Hyperthermia	MG26	Approved	[6]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[6]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[6]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[6]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[6]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[6]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[6]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[6]

Drug(s) Affected By Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[356]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[356]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[357]
Sunitinib	DMCBJSR	Acute undifferentiated leukemia		Approved	[92]
Rosuvastatin	DMMIQ7G	Arteriosclerosis	BD40	Approved	[358]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[111]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[359]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[360]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[361]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[362]

Drug(s) Affected By Epoxide hydrolase 1 (EPHX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[363]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[364]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[365]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[366]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[367]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[368]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[345]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[139]

Drug(s) Affected By Cytochrome P450 2C19 (CYP2C19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[39]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[369]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[41]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[370]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[371]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[42]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[372]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[42]
Desipramine	DMT2FDC	Attention deficit hyperactivity disorder	6A05.Z	Approved	[369]
Amitriptyline	DMK7F9S	Depression	6A70-6A7Z	Approved	[92]

Drug(s) Affected By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[39]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[373]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[42]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[41]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[371]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[374]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[42]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[375]
Fluconazole	DMOWZ6B	Cryptococcal meningitis		Approved	[41]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[42]

Drug(s) Affected By Cytochrome P450 1A2 (CYP1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zolmitriptan	DM1IB4Q	Migraine	8A80	Approved	[376]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[376]
Etoricoxib	DM6A4NW	Rheumatoid arthritis	FA20	Approved	[376]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[371]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[377]
Stiripentol	DMMSDOY	Dravet syndrome	8A61.11	Approved	[372]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[378]
Zileuton	DMVRIC2	Allergic asthma	CA23.0	Approved	[379]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[380]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[92]

Drug(s) Affected By Cytochrome P450 2B6 (CYP2B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[370]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[381]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[382]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[383]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[384]
Clopidogrel	DMOL54H	Acute coronary syndrome	BA41	Approved	[385]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[386]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[387]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[388]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[389]

Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[390]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[273]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[391]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[392]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[393]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[394]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[395]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[396]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[397]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[208]

Drug(s) Affected By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[398]
Paliperidone	DM7NPJS	Psychotic disorder	6A20-6A25	Approved	[399]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[400]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[401]
Oxatomide	DM1F42Z	Hay fever	CA08.00	Approved	[402]
Cinacalcet	DMCX0K3	Hyperparathyroidism	5A51	Approved	[403]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[371]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[42]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[404]
Buprenorphine	DMPRI8G	Opioid dependence	6C43.2Z	Approved	[405]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Lactotransferrin (LTF)	TTSZDQU	TRFL_HUMAN	Inhibitor	[2]
Prostaglandin G/H synthase 2 (COX-2)	TTVKILB	PGH2_HUMAN	Inhibitor	[2]
TNF related apoptosis inducing ligand (TNFSF10)	TTA5MS9	TNF10_HUMAN	Modulator	[3]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4) Main DME	DE4LYSA	CP3A4_HUMAN	Substrate	[4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Angiopoietin-related protein 4 (ANGPTL4)	OTQL5SPX	ANGL4_HUMAN	Gene/Protein Processing	[5]
Angiotensin-converting enzyme 2 (ACE2)	OTTRZGU7	ACE2_HUMAN	Gene/Protein Processing	[6]
Antileukoproteinase (SLPI)	OTUNFUU8	SLPI_HUMAN	Gene/Protein Processing	[7]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[8]
Aromatase (CYP19A1)	OTZ6XF74	CP19A_HUMAN	Gene/Protein Processing	[9]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Gene/Protein Processing	[10]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Gene/Protein Processing	[11]
Bone morphogenetic protein 6 (BMP6)	OT9WN536	BMP6_HUMAN	Gene/Protein Processing	[7]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)	OTW8V2V1	ABCG2_HUMAN	Gene/Protein Processing	[12]
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Gene/Protein Processing	[13]

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