Details of the Drug Combination

General Information of Drug Combination (ID: DCFN16E)

• Drug Combination Name: Clozapine + Cycloserine
• Indication: Schizophrenia; Status: Phase 3 [1]
• Component Drugs:
  Clozapine (DMFC71L): Small molecular drug
  Cycloserine (DMT1I52): Small molecular drug

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Clozapine

Disease Entry	ICD 11	Status	REF
Schizophrenia	6A20	Approved	[2]
Treatment-refractory schizophrenia	N.A.	Investigative	[3]

Clozapine Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Dopamine D4 receptor (D4R)	TTE0A2F	DRD4_HUMAN	Modulator	[11]

Clozapine Interacts with 1 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[12]

Clozapine Interacts with 7 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[13]
Cytochrome P450 1A2 (CYP1A2)	DEJGDUW	CP1A2_HUMAN	Metabolism	[14]
Cytochrome P450 2A6 (CYP2A6)	DEJVYAZ	CP2A6_HUMAN	Metabolism	[15]
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Metabolism	[16]
Cytochrome P450 2C8 (CYP2C8)	DES5XRU	CP2C8_HUMAN	Metabolism	[17]
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Metabolism	[17]
Mephenytoin 4-hydroxylase (CYP2C19)	DEGTFWK	CP2CJ_HUMAN	Metabolism	[13]

Clozapine Interacts with 389 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Decreases Activity	[18]
D(4) dopamine receptor (DRD4)	OTAJTO7N	DRD4_HUMAN	Affects Response To Substance	[19]
D(3) dopamine receptor (DRD3)	OT0OFFKB	DRD3_HUMAN	Decreases Response To Substance	[20]
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 (GNB3)	OTA6HYBA	GBB3_HUMAN	Decreases Response To Substance	[21]
D(2) dopamine receptor (DRD2)	OTBLXKEG	DRD2_HUMAN	Increases Response To Substance	[22]
Nuclear protein 1 (NUPR1)	OT4FU8C0	NUPR1_HUMAN	Increases Expression	[7]
Alpha-1-antichymotrypsin (SERPINA3)	OT9BP2S0	AACT_HUMAN	Increases Expression	[7]
Serine protease hepsin (HPN)	OT7QNA61	HEPS_HUMAN	Increases Expression	[7]
Fatty acid-binding protein, liver (FABP1)	OTR34ETM	FABPL_HUMAN	Increases Expression	[7]
Asparagine synthetase (ASNS)	OT8R922G	ASNS_HUMAN	Increases Expression	[7]
Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3)	OT2HZK5M	GTR3_HUMAN	Decreases Expression	[7]
Lanosterol synthase (LSS)	OT9W2SFH	LSS_HUMAN	Increases Expression	[7]
Inhibin beta E chain (INHBE)	OTOI2NYG	INHBE_HUMAN	Increases Expression	[7]
Transgelin (TAGLN)	OTAEZ0KP	TAGL_HUMAN	Decreases Expression	[7]
Acid ceramidase (ASAH1)	OT1DNGXL	ASAH1_HUMAN	Increases Expression	[7]
Nuclear receptor subfamily 0 group B member 2 (NR0B2)	OT7UVICX	NR0B2_HUMAN	Increases Expression	[7]
Lysophospholipase D GDPD3 (GDPD3)	OTOHM9QM	GDPD3_HUMAN	Increases Expression	[7]
Fibronectin type III domain-containing protein 4 (FNDC4)	OTOQK0WK	FNDC4_HUMAN	Increases Expression	[7]
Protein DEPP1 (DEPP1)	OTB36PHJ	DEPP1_HUMAN	Increases Expression	[7]
Stearoyl-CoA desaturase (SCD)	OTB1073G	SCD_HUMAN	Increases Expression	[23]
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)	OTRT3F3U	HMDH_HUMAN	Increases Expression	[23]
Fatty acid synthase (FASN)	OTFII9KG	FAS_HUMAN	Increases Expression	[23]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)	OTCO26FV	HMCS1_HUMAN	Increases Expression	[23]
Lathosterol oxidase (SC5D)	OT41KMW4	SC5D_HUMAN	Increases Expression	[24]
Low-density lipoprotein receptor (LDLR)	OTH559LU	LDLR_HUMAN	Increases Expression	[24]
Farnesyl pyrophosphate synthase (FDPS)	OT6CKWV5	FPPS_HUMAN	Increases Expression	[24]
Sterol regulatory element-binding protein 1 (SREBF1)	OTWBRPAI	SRBP1_HUMAN	Increases Expression	[24]
Sterol regulatory element-binding protein 2 (SREBF2)	OTBXUNPL	SRBP2_HUMAN	Increases Expression	[24]
Acetyl-CoA acetyltransferase, cytosolic (ACAT2)	OTZ092ZJ	THIC_HUMAN	Increases Expression	[24]
7-dehydrocholesterol reductase (DHCR7)	OTLILBUI	DHCR7_HUMAN	Increases Expression	[24]
AP-1 complex subunit sigma-1A (AP1S1)	OTQ2H8DN	AP1S1_HUMAN	Decreases Expression	[25]
Heme oxygenase 1 (HMOX1)	OTC1W6UX	HMOX1_HUMAN	Increases Expression	[8]
Glutathione S-transferase P (GSTP1)	OTLP0A0Y	GSTP1_HUMAN	Decreases Activity	[26]
Uncharacterized protein CXorf49 (CXORF49)	OTMZ66NA	CX049_HUMAN	Increases Expression	[9]
Cytosolic acyl coenzyme A thioester hydrolase (ACOT7)	OT7C68YV	BACH_HUMAN	Decreases Expression	[9]
AP-3 complex subunit beta-1 (AP3B1)	OTYTIH5Q	AP3B1_HUMAN	Increases Expression	[9]
Galectin-8 (LGALS8)	OT71LJ8T	LEG8_HUMAN	Increases Expression	[27]
26S proteasome non-ATPase regulatory subunit 14 (PSMD14)	OTJWHMZ5	PSDE_HUMAN	Increases Expression	[9]
Syntenin-1 (SDCBP)	OTS3NCC5	SDCB1_HUMAN	Decreases Expression	[9]
Importin subunit alpha-3 (KPNA4)	OTP0EX18	IMA3_HUMAN	Increases Expression	[9]
Dihydropyrimidinase-related protein 4 (DPYSL4)	OT3SBS2S	DPYL4_HUMAN	Decreases Expression	[9]
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (CDIPT)	OTZX703K	CDIPT_HUMAN	Increases Expression	[9]
Serine palmitoyltransferase 1 (SPTLC1)	OTN0Z98K	SPTC1_HUMAN	Decreases Expression	[9]
Cytoplasmic dynein 1 light intermediate chain 2 (DYNC1LI2)	OTR7WJES	DC1L2_HUMAN	Decreases Expression	[9]
E3 ubiquitin-protein ligase RNF13 (RNF13)	OT7HNYF4	RNF13_HUMAN	Increases Expression	[27]
Calumenin (CALU)	OTSYQN71	CALU_HUMAN	Decreases Expression	[9]
Kinesin heavy chain isoform 5C (KIF5C)	OT35570Y	KIF5C_HUMAN	Decreases Expression	[9]
Heterogeneous nuclear ribonucleoprotein Q (SYNCRIP)	OTRNDZXB	HNRPQ_HUMAN	Decreases Expression	[9]
Tetraspanin-3 (TSPAN3)	OT7WS6ZI	TSN3_HUMAN	Decreases Expression	[9]
Eukaryotic translation initiation factor 5B (EIF5B)	OTZTT22W	IF2P_HUMAN	Increases Expression	[9]
U5 small nuclear ribonucleoprotein 200 kDa helicase (SNRNP200)	OTSAU864	U520_HUMAN	Increases Expression	[9]
Eukaryotic translation initiation factor 3 subunit J (EIF3J)	OTJ4TAWK	EIF3J_HUMAN	Increases Expression	[9]
Glutaredoxin-3 (GLRX3)	OTUPAU1N	GLRX3_HUMAN	Increases Expression	[9]
Pre-mRNA-processing factor 6 (PRPF6)	OT3U0ABN	PRP6_HUMAN	Decreases Expression	[9]
Protein transport protein Sec31A (SEC31A)	OT2U42AC	SC31A_HUMAN	Increases Expression	[9]
Tumor necrosis factor ligand superfamily member 15 (TNFSF15)	OTNGA2BW	TNF15_HUMAN	Decreases Expression	[28]
Bile salt export pump (ABCB11)	OTRU7THO	ABCBB_HUMAN	Decreases Activity	[29]
Structural maintenance of chromosomes protein 2 (SMC2)	OT5S0DV4	SMC2_HUMAN	Decreases Expression	[9]
Neuroendocrine secretory protein 55 (GNAS)	OTMH8BKJ	GNAS3_HUMAN	Increases Expression	[9]
Superoxide dismutase (SOD1)	OT39TA1L	SODC_HUMAN	Decreases Expression	[9]
Adenylate kinase isoenzyme 1 (AK1)	OT614AR3	KAD1_HUMAN	Decreases Expression	[9]
Argininosuccinate synthase (ASS1)	OT4ZMG0Q	ASSY_HUMAN	Increases Expression	[9]
Prolactin (PRL)	OTWFQGX7	PRL_HUMAN	Increases Secretion	[30]
Insulin (INS)	OTZ85PDU	INS_HUMAN	Increases Expression	[31]
Interferon gamma (IFNG)	OTXG9JM7	IFNG_HUMAN	Decreases Expression	[28]
Interleukin-2 receptor subunit alpha (IL2RA)	OT0MWCHG	IL2RA_HUMAN	Increases Secretion	[32]
Myelin basic protein (MBP)	OTFZCEDB	MBP_HUMAN	Increases Expression	[28]
C-reactive protein (CRP)	OT0RFT8F	CRP_HUMAN	Increases Expression	[33]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Affects Binding	[34]
C-X-C motif chemokine 10 (CXCL10)	OTTLQ6S0	CXL10_HUMAN	Decreases Secretion	[27]
Vitamin K-dependent protein C (PROC)	OTGVH484	PROC_HUMAN	Increases Expression	[35]
Annexin A1 (ANXA1)	OT5OFDJC	ANXA1_HUMAN	Decreases Expression	[9]
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)	OTBPMIMW	G3P_HUMAN	Increases Expression	[9]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Increases Expression	[36]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Decreases Activity	[37]
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (RPN2)	OTJ1SKOA	RPN2_HUMAN	Decreases Expression	[9]
Insulin-like growth factor I (IGF1)	OTIIZR61	IGF1_HUMAN	Decreases Expression	[38]
Fructose-bisphosphate aldolase B (ALDOB)	OT7FR69A	ALDOB_HUMAN	Decreases Expression	[27]
Amyloid-beta precursor protein (APP)	OTKFD7R4	A4_HUMAN	Increases Expression	[27]
Interleukin-5 (IL5)	OTAFPSCO	IL5_HUMAN	Affects Expression	[28]
Myeloperoxidase (MPO)	OTOOXLIN	PERM_HUMAN	Increases Activity	[39]
Myosin light chain 1/3, skeletal muscle isoform (MYL1)	OTDUYR4U	MYL1_HUMAN	Increases Expression	[9]
Prothymosin alpha (PTMA)	OT2W4T1M	PTMA_HUMAN	Increases Expression	[9]
Glucose-6-phosphate isomerase (GPI)	OTEGSRXG	G6PI_HUMAN	Increases Expression	[9]
Corticoliberin (CRH)	OT2MOC4T	CRF_HUMAN	Decreases Expression	[40]
Annexin A6 (ANXA6)	OT9KIQ0Y	ANXA6_HUMAN	Decreases Expression	[9]
Amino acid transporter heavy chain SLC3A2 (SLC3A2)	OTBR33M9	4F2_HUMAN	Increases Expression	[27]
Annexin A5 (ANXA5)	OTZS877V	ANXA5_HUMAN	Decreases Expression	[9]
Insulin-like growth factor-binding protein 1 (IGFBP1)	OT6UQV2K	IBP1_HUMAN	Increases Expression	[27]
CD63 antigen (CD63)	OT2UGZA9	CD63_HUMAN	Increases Expression	[27]
Matrilysin (MMP7)	OTVT3SEJ	MMP7_HUMAN	Decreases Expression	[28]
Stromelysin-2 (MMP10)	OTJDWW8Q	MMP10_HUMAN	Decreases Expression	[28]
Growth-regulated alpha protein (CXCL1)	OT3WCTZV	GROA_HUMAN	Decreases Expression	[28]
Dihydropteridine reductase (QDPR)	OTSKOIUX	DHPR_HUMAN	Decreases Expression	[9]
2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP)	OTB8HCED	CN37_HUMAN	Decreases Expression	[9]
Leukotriene A-4 hydrolase (LTA4H)	OTWSZ0QT	LKHA4_HUMAN	Decreases Expression	[9]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Decreases Secretion	[27]
Osteopontin (SPP1)	OTJGC23Y	OSTP_HUMAN	Decreases Expression	[28]
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (DLAT)	OT9LBJVN	ODP2_HUMAN	Increases Expression	[9]
Myosin-3 (MYH3)	OTOCCGEB	MYH3_HUMAN	Increases Expression	[9]
Muscarinic acetylcholine receptor M1 (CHRM1)	OTKW3E6B	ACM1_HUMAN	Affects Binding	[41]
Lysosome-associated membrane glycoprotein 1 (LAMP1)	OTYE92QY	LAMP1_HUMAN	Increases Expression	[9]
Glucose-6-phosphate 1-dehydrogenase (G6PD)	OT300SMK	G6PD_HUMAN	Decreases Expression	[9]
Histidine--tRNA ligase, cytoplasmic (HARS1)	OTHOEOTS	HARS1_HUMAN	Increases Expression	[9]
ADP/ATP translocase 3 (SLC25A6)	OT9KAJP7	ADT3_HUMAN	Increases Expression	[9]
Nucleoprotein TPR (TPR)	OTUBBA4W	TPR_HUMAN	Decreases Expression	[9]
HLA class I histocompatibility antigen, alpha chain E (HLA-E)	OTX1CTFB	HLAE_HUMAN	Increases Expression	[27]
Plastin-3 (PLS3)	OTYBM4PK	PLST_HUMAN	Decreases Expression	[9]
Beta-enolase (ENO3)	OT3HYKYI	ENOB_HUMAN	Increases Expression	[9]
Small nuclear ribonucleoprotein-associated proteins B and B' (SNRPB)	OT3UJ4ZU	RSMB_HUMAN	Increases Expression	[9]
Glutamine synthetase (GLUL)	OTYGTCGF	GLNA_HUMAN	Decreases Expression	[27]
Interferon gamma receptor 1 (IFNGR1)	OTCTQBWW	INGR1_HUMAN	Increases Expression	[27]
Ezrin (EZR)	OTHBPF1Z	EZRI_HUMAN	Decreases Expression	[9]
V-type proton ATPase subunit B, kidney isoform (ATP6V1B1)	OT8FQ7MN	VATB1_HUMAN	Decreases Expression	[9]
Histone H1.2 (H1-2)	OT0AVI4M	H12_HUMAN	Increases Expression	[9]
26S proteasome regulatory subunit 6A (PSMC3)	OTSKT0JI	PRS6A_HUMAN	Increases Expression	[9]
V-type proton ATPase subunit B, brain isoform (ATP6V1B2)	OTNX2V4Z	VATB2_HUMAN	Decreases Expression	[9]
Trifunctional purine biosynthetic protein adenosine-3 (GART)	OT01JWJB	PUR2_HUMAN	Increases Expression	[9]
C-C motif chemokine 1 (CCL1)	OT23NON8	CCL1_HUMAN	Decreases Expression	[28]
Integrin alpha-6 (ITGA6)	OT3FA39C	ITA6_HUMAN	Increases Expression	[9]
Splicing factor, proline- and glutamine-rich (SFPQ)	OTLCIAPJ	SFPQ_HUMAN	Decreases Expression	[9]
Small ribosomal subunit protein uS3 (RPS3)	OT0K3TMH	RS3_HUMAN	Decreases Expression	[9]
Tyrosine-protein kinase JAK1 (JAK1)	OT0X3D17	JAK1_HUMAN	Increases Expression	[27]
High mobility group protein B2 (HMGB2)	OTGEGAOK	HMGB2_HUMAN	Increases Expression	[9]
Replication protein A 70 kDa DNA-binding subunit (RPA1)	OT76POLP	RFA1_HUMAN	Decreases Expression	[9]
Calreticulin (CALR)	OTYD2TR1	CALR_HUMAN	Decreases Expression	[9]
Calnexin (CANX)	OTYP1F6J	CALX_HUMAN	Decreases Expression	[9]
Caspase-1 (CASP1)	OTZ3YQFU	CASP1_HUMAN	Increases Activity	[42]
Elongation factor 1-delta (EEF1D)	OTM5ZD8Y	EF1D_HUMAN	Decreases Expression	[9]
Phosphatidylethanolamine-binding protein 1 (PEBP1)	OTQ5FEI0	PEBP1_HUMAN	Decreases Expression	[9]
Protein disulfide-isomerase A3 (PDIA3)	OTHPQ0Q3	PDIA3_HUMAN	Decreases Expression	[9]
Lipocalin-1 (LCN1)	OT8BWXTV	LCN1_HUMAN	Decreases Expression	[9]
S-adenosylmethionine synthase isoform type-2 (MAT2A)	OTFJMIQR	METK2_HUMAN	Decreases Expression	[9]
RAC-alpha serine/threonine-protein kinase (AKT1)	OT8H2YY7	AKT1_HUMAN	Increases Expression	[43]
Stress-induced-phosphoprotein 1 (STIP1)	OT7TXLOX	STIP1_HUMAN	Decreases Expression	[9]
Pyrroline-5-carboxylate reductase 1, mitochondrial (PYCR1)	OTQHB52T	P5CR1_HUMAN	Increases Expression	[9]
Cleavage stimulation factor subunit 2 (CSTF2)	OTR6G4II	CSTF2_HUMAN	Decreases Expression	[9]
5-hydroxytryptamine receptor 7 (HTR7)	OT44DEWB	5HT7R_HUMAN	Affects Binding	[44]
Histamine H1 receptor (HRH1)	OT8F9FV6	HRH1_HUMAN	Affects Binding	[45]
Vascular endothelial growth factor receptor 2 (KDR)	OT15797V	VGFR2_HUMAN	Increases Expression	[9]
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (DLST)	OTBDF9HJ	ODO2_HUMAN	Decreases Expression	[9]
Transgelin-2 (TAGLN2)	OTUXZGDQ	TAGL2_HUMAN	Decreases Expression	[9]
Lysosomal acid lipase/cholesteryl ester hydrolase (LIPA)	OTIOLNHE	LICH_HUMAN	Increases Expression	[9]
V-type proton ATPase catalytic subunit A (ATP6V1A)	OTYZ2S9E	VATA_HUMAN	Decreases Expression	[9]
Stress-70 protein, mitochondrial (HSPA9)	OT4TMVS9	GRP75_HUMAN	Decreases Expression	[9]
Flap endonuclease 1 (FEN1)	OT6QGG7O	FEN1_HUMAN	Increases Expression	[9]
Nicotinamide N-methyltransferase (NNMT)	OTFM38GU	NNMT_HUMAN	Increases Expression	[9]
Malate dehydrogenase, cytoplasmic (MDH1)	OTJEO4E8	MDHC_HUMAN	Decreases Expression	[9]
Replication factor C subunit 5 (RFC5)	OTAD79RT	RFC5_HUMAN	Increases Expression	[9]
Eukaryotic translation initiation factor 2 subunit 3 (EIF2S3)	OTARRES9	IF2G_HUMAN	Increases Expression	[9]
N-alpha-acetyltransferase 10 (NAA10)	OTYB9R6I	NAA10_HUMAN	Decreases Expression	[9]
Lamina-associated polypeptide 2, isoform alpha (TMPO)	OTL68EL4	LAP2A_HUMAN	Decreases Expression	[9]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Increases Activity	[46]
Leucine-rich PPR motif-containing protein, mitochondrial (LRPPRC)	OTXSK5LP	LPPRC_HUMAN	Increases Expression	[9]
C-X-C motif chemokine 5 (CXCL5)	OTZOUPCA	CXCL5_HUMAN	Decreases Expression	[28]
Glycerol-3-phosphate dehydrogenase, mitochondrial (GPD2)	OTV232Y7	GPDM_HUMAN	Decreases Expression	[9]
ATP-binding cassette sub-family G member 1 (ABCG1)	OT5BG6MK	ABCG1_HUMAN	Increases Expression	[28]
Vesicle-fusing ATPase (NSF)	OTKRJ2ZT	NSF_HUMAN	Decreases Expression	[9]
Large ribosomal subunit protein uL18 (RPL5)	OTM8EBRI	RL5_HUMAN	Increases Expression	[9]
Microtubule-associated protein 1B (MAP1B)	OTVXW089	MAP1B_HUMAN	Decreases Expression	[9]
3-hydroxyanthranilate 3,4-dioxygenase (HAAO)	OTK9Y6SG	3HAO_HUMAN	Decreases Expression	[27]
Nestin (NES)	OTZ9PZ14	NEST_HUMAN	Decreases Expression	[9]
Phosphatidylinositol transfer protein beta isoform (PITPNB)	OTNM6T78	PIPNB_HUMAN	Increases Expression	[9]
Alanine--tRNA ligase, cytoplasmic (AARS1)	OTW8D813	SYAC_HUMAN	Increases Expression	[9]
Cysteine--tRNA ligase, cytoplasmic (CARS1)	OTOUZF6O	SYCC_HUMAN	Increases Expression	[9]
Serine--tRNA ligase, cytoplasmic (SARS1)	OTFKXQ1O	SYSC_HUMAN	Decreases Expression	[9]
Acyl-coenzyme A thioesterase 2, mitochondrial (ACOT2)	OTAKUO27	ACOT2_HUMAN	Increases Expression	[9]
Transmembrane emp24 domain-containing protein 10 (TMED10)	OTUXSHH7	TMEDA_HUMAN	Decreases Expression	[9]
Glycogen synthase kinase-3 beta (GSK3B)	OTL3L14B	GSK3B_HUMAN	Increases Phosphorylation	[43]
Matrix metalloproteinase-14 (MMP14)	OT9C197Z	MMP14_HUMAN	Increases Expression	[27]
5-hydroxytryptamine receptor 6 (HTR6)	OT8GTDDY	5HT6R_HUMAN	Affects Binding	[45]
Glycine amidinotransferase, mitochondrial (GATM)	OTIJ4Z11	GATM_HUMAN	Increases Expression	[9]
26S proteasome non-ATPase regulatory subunit 7 (PSMD7)	OT7PZZ4K	PSMD7_HUMAN	Increases Expression	[9]
Rap1 GTPase-GDP dissociation stimulator 1 (RAP1GDS1)	OTH70UHD	GDS1_HUMAN	Increases Expression	[9]
Succinate--CoA ligase subunit alpha, mitochondrial (SUCLG1)	OTDCSPXH	SUCA_HUMAN	Decreases Expression	[9]
Ephrin type-B receptor 3 (EPHB3)	OT4XD8O3	EPHB3_HUMAN	Increases Expression	[9]
Trifunctional enzyme subunit beta, mitochondrial (HADHB)	OT4Y1I62	ECHB_HUMAN	Increases Expression	[9]
Caspase-7 (CASP7)	OTAPJ040	CASP7_HUMAN	Increases Activity	[46]
Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2)	OTMGP4J7	HNRH2_HUMAN	Decreases Expression	[27]
Eukaryotic translation initiation factor 6 (EIF6)	OTEXMUED	IF6_HUMAN	Decreases Expression	[9]
Breast cancer anti-estrogen resistance protein 1 (BCAR1)	OTKT2C2N	BCAR1_HUMAN	Decreases Expression	[9]
Protein transport protein Sec61 subunit beta (SEC61B)	OTY1X6A2	SC61B_HUMAN	Increases Expression	[9]
Gamma-aminobutyric acid receptor-associated protein-like 2 (GABARAPL2)	OTS7YVHF	GBRL2_HUMAN	Increases Expression	[27]
Actin, cytoplasmic 1 (ACTB)	OT1MCP2F	ACTB_HUMAN	Decreases Expression	[9]
Actin-related protein 3 (ACTR3)	OT05LJSH	ARP3_HUMAN	Decreases Expression	[9]
ATP-binding cassette sub-family E member 1 (ABCE1)	OTH19LOA	ABCE1_HUMAN	Increases Expression	[9]
26S proteasome regulatory subunit 8 (PSMC5)	OTJOORMR	PRS8_HUMAN	Increases Expression	[9]
Small ribosomal subunit protein uS17 (RPS11)	OTILZE44	RS11_HUMAN	Decreases Expression	[9]
Rho-related GTP-binding protein RhoB (RHOB)	OTHQFQF7	RHOB_HUMAN	Increases Expression	[27]
GTP-binding nuclear protein Ran (RAN)	OT2TER5M	RAN_HUMAN	Decreases Expression	[9]
Large ribosomal subunit protein eL30 (RPL30)	OTLQVY1Z	RL30_HUMAN	Increases Expression	[9]
Large ribosomal subunit protein uL5 (RPL11)	OT3VZ6OE	RL11_HUMAN	Increases Expression	[9]
Transformer-2 protein homolog beta (TRA2B)	OTZYQW52	TRA2B_HUMAN	Decreases Expression	[9]
S-phase kinase-associated protein 1 (SKP1)	OT5BPAZ4	SKP1_HUMAN	Decreases Expression	[9]
Small ribosomal subunit protein RACK1 (RACK1)	OTZBCQ1U	RACK1_HUMAN	Decreases Expression	[9]
BOS complex subunit NOMO3 (NOMO3)	OTTOCIRA	NOMO3_HUMAN	Increases Expression	[9]
Microtubule-associated protein 1A (MAP1A)	OTHO8K43	MAP1A_HUMAN	Decreases Expression	[9]
Dermcidin (DCD)	OTV5PBGJ	DCD_HUMAN	Decreases Expression	[9]
Enhancer of rudimentary homolog (ERH)	OTJDWX99	ERH_HUMAN	Increases Expression	[9]
Large ribosomal subunit protein eL19 (RPL19)	OT33LM66	RL19_HUMAN	Increases Expression	[9]
Disabled homolog 2 (DAB2)	OTRMQTMZ	DAB2_HUMAN	Increases Expression	[27]
Protein Dr1 (DR1)	OTR081M4	NC2B_HUMAN	Decreases Expression	[9]
Melanocyte-stimulating hormone receptor (MC1R)	OTB95LIK	MSHR_HUMAN	Increases Expression	[28]
Pro-neuregulin-1, membrane-bound isoform (NRG1)	OTZO6F1X	NRG1_HUMAN	Increases Expression	[47]
Guanine nucleotide-binding protein subunit alpha-12 (GNA12)	OT3IRZH3	GNA12_HUMAN	Increases Expression	[9]
Histone-lysine N-methyltransferase 2A (KMT2A)	OT9GLJI6	KMT2A_HUMAN	Increases Expression	[48]
Neurogenic locus notch homolog protein 2 (NOTCH2)	OTQ3Y9PA	NOTC2_HUMAN	Increases Expression	[27]
Cleavage stimulation factor subunit 1 (CSTF1)	OTYSXAX6	CSTF1_HUMAN	Decreases Expression	[9]
Focal adhesion kinase 1 (PTK2)	OT3Q1JDY	FAK1_HUMAN	Increases Expression	[9]
Elongation factor 1-alpha 2 (EEF1A2)	OT9Z23K5	EF1A2_HUMAN	Increases Expression	[9]
Cytoskeleton-associated protein 4 (CKAP4)	OTDUC9ME	CKAP4_HUMAN	Increases Expression	[9]
KH domain-containing, RNA-binding, signal transduction-associated protein 1 (KHDRBS1)	OT5GO2PL	KHDR1_HUMAN	Decreases Expression	[9]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Increases Expression	[36]
Golgin subfamily A member 3 (GOLGA3)	OT27354E	GOGA3_HUMAN	Increases Expression	[9]
Fibrinogen-like protein 1 (FGL1)	OTT0QHQ1	FGL1_HUMAN	Increases Expression	[27]
Histone-binding protein RBBP4 (RBBP4)	OTG3BT3M	RBBP4_HUMAN	Decreases Expression	[9]
Nuclear cap-binding protein subunit 1 (NCBP1)	OTYBR927	NCBP1_HUMAN	Decreases Expression	[9]
TBC1 domain family member 8B (TBC1D8B)	OTSYGOXH	TBC8B_HUMAN	Increases Expression	[9]
Nuclear pore complex protein Nup160 (NUP160)	OTUKVV3I	NU160_HUMAN	Increases Expression	[9]
Transducin beta-like protein 3 (TBL3)	OT14XY62	TBL3_HUMAN	Increases Expression	[9]
Aspartyl/asparaginyl beta-hydroxylase (ASPH)	OT3KGDEE	ASPH_HUMAN	Increases Expression	[9]
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 (SMARCB1)	OT2LP7LJ	SNF5_HUMAN	Decreases Expression	[9]
Oviduct-specific glycoprotein (OVGP1)	OTL2W9M5	OVGP1_HUMAN	Increases Expression	[28]
Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 (AIMP1)	OTTA5C3U	AIMP1_HUMAN	Increases Expression	[9]
Serine/arginine-rich splicing factor 5 (SRSF5)	OTC5WP98	SRSF5_HUMAN	Increases Expression	[9]
Transcription intermediary factor 1-beta (TRIM28)	OTE38OBF	TIF1B_HUMAN	Decreases Expression	[9]
Bcl-2-interacting killer (BIK)	OTTH1T3D	BIK_HUMAN	Increases Expression	[36]
C-terminal-binding protein 1 (CTBP1)	OTVYH2DH	CTBP1_HUMAN	Increases Expression	[9]
NAD(P) transhydrogenase, mitochondrial (NNT)	OTAIOGZK	NNTM_HUMAN	Decreases Expression	[9]
Sequestosome-1 (SQSTM1)	OTGY5D5J	SQSTM_HUMAN	Increases Expression	[27]
Stromal interaction molecule 1 (STIM1)	OT8CLQ1W	STIM1_HUMAN	Decreases Expression	[9]
Sorting nexin-1 (SNX1)	OTXQSJ1J	SNX1_HUMAN	Decreases Expression	[9]
Cullin-2 (CUL2)	OTPF83PG	CUL2_HUMAN	Increases Expression	[9]
Cullin-3 (CUL3)	OTDNOAPM	CUL3_HUMAN	Increases Expression	[9]
Nuclear receptor coactivator 4 (NCOA4)	OTRVU0UA	NCOA4_HUMAN	Increases Expression	[27]
Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)	OTGM06VJ	IDI1_HUMAN	Decreases Expression	[9]
Heterogeneous nuclear ribonucleoprotein D0 (HNRNPD)	OT5UO1FA	HNRPD_HUMAN	Decreases Expression	[9]
Protein DGCR6 (DGCR6)	OTBOXM33	DGCR6_HUMAN	Decreases Expression	[9]
Single-minded homolog 2 (SIM2)	OT0QWHK4	SIM2_HUMAN	Decreases Expression	[9]
Dihydropyrimidinase-related protein 3 (DPYSL3)	OTINJV20	DPYL3_HUMAN	Decreases Expression	[9]
Src substrate cortactin (CTTN)	OTJRG4ES	SRC8_HUMAN	Increases Expression	[9]
Flotillin-2 (FLOT2)	OTZ0QR5L	FLOT2_HUMAN	Increases Expression	[9]
Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8)	OT8RPSOC	FKBP8_HUMAN	Decreases Expression	[9]
Protein RRP5 homolog (PDCD11)	OTS1NJK2	RRP5_HUMAN	Increases Expression	[9]
Golgin subfamily B member 1 (GOLGB1)	OT2S0GK8	GOGB1_HUMAN	Increases Expression	[9]
Chromodomain-helicase-DNA-binding protein 4 (CHD4)	OTBDEHDP	CHD4_HUMAN	Decreases Expression	[9]
Condensin complex subunit 2 (NCAPH)	OTXOS97C	CND2_HUMAN	Decreases Expression	[9]
Serum paraoxonase/lactonase 3 (PON3)	OT80W9TA	PON3_HUMAN	Increases Expression	[9]
Inorganic pyrophosphatase (PPA1)	OTHZK1QB	IPYR_HUMAN	Increases Expression	[9]
Periodic tryptophan protein 2 homolog (PWP2)	OTG6BNPG	PWP2_HUMAN	Increases Expression	[9]
Poly(rC)-binding protein 1 (PCBP1)	OTHN0TD7	PCBP1_HUMAN	Increases Expression	[9]
Delta(24)-sterol reductase (DHCR24)	OTP301JW	DHC24_HUMAN	Increases Expression	[9]
Scaffold attachment factor B1 (SAFB)	OTGRV2LW	SAFB1_HUMAN	Increases Expression	[9]
Microtubule-associated protein RP/EB family member 1 (MAPRE1)	OTCVQD60	MARE1_HUMAN	Decreases Expression	[9]
Disks large homolog 2 (DLG2)	OTQ3BD8U	DLG2_HUMAN	Increases Expression	[9]
Adiponectin (ADIPOQ)	OTNX23LE	ADIPO_HUMAN	Decreases Expression	[49]
Serine/arginine-rich splicing factor 7 (SRSF7)	OTRS4W4S	SRSF7_HUMAN	Decreases Expression	[9]
Cytochrome P450 1B1 (CYP1B1)	OTYXFLSD	CP1B1_HUMAN	Decreases Activity	[37]
Histone H2A type 2-C (H2AC20)	OTEIVLM1	H2A2C_HUMAN	Increases Expression	[9]
Phosphoenolpyruvate carboxykinase , mitochondrial (PCK2)	OTJ8LX4N	PCKGM_HUMAN	Decreases Expression	[9]
La-related protein 7 (LARP7)	OTLLOZTL	LARP7_HUMAN	Increases Expression	[9]
Very-long-chain 3-oxoacyl-CoA reductase (HSD17B12)	OTW95XD4	DHB12_HUMAN	Increases Expression	[9]
Endoribonuclease LACTB2 (LACTB2)	OTU4IFBU	LACB2_HUMAN	Increases Expression	[9]
Beta-actin-like protein 2 (ACTBL2)	OTD6B81U	ACTBL_HUMAN	Increases Expression	[9]
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)	OTLS7C99	LRRK2_HUMAN	Increases Expression	[9]
ATPase family AAA domain-containing protein 3B (ATAD3B)	OTL508AF	ATD3B_HUMAN	Increases Expression	[9]
Tau-tubulin kinase 1 (TTBK1)	OTYW316L	TTBK1_HUMAN	Increases Expression	[9]
CD276 antigen (CD276)	OTKHTFVO	CD276_HUMAN	Decreases Expression	[9]
Microtubule-associated protein 1S (MAP1S)	OT5WUD4C	MAP1S_HUMAN	Increases Expression	[9]
Actin-binding LIM protein 2 (ABLIM2)	OT62KOXF	ABLM2_HUMAN	Increases Expression	[28]
Mitochondrial adenyl nucleotide antiporter SLC25A24 (SLC25A24)	OT3ZNGEL	SCMC1_HUMAN	Increases Expression	[9]
Enhancer of mRNA-decapping protein 4 (EDC4)	OTBBNIUJ	EDC4_HUMAN	Increases Expression	[9]
Leiomodin-2 (LMOD2)	OTFXHQFL	LMOD2_HUMAN	Increases Expression	[9]
Septin-14 (SEPTIN14)	OTCM6DDO	SEP14_HUMAN	Decreases Expression	[9]
Probable ATP-dependent RNA helicase DDX46 (DDX46)	OTB2X9TO	DDX46_HUMAN	Increases Expression	[9]
eIF5-mimic protein 2 (BZW1)	OT4GUFIG	5MP2_HUMAN	Increases Expression	[9]
ATP-dependent RNA helicase DHX30 (DHX30)	OT7W9CEZ	DHX30_HUMAN	Increases Expression	[9]
Probable helicase senataxin (SETX)	OTG3JNOQ	SETX_HUMAN	Increases Expression	[9]
Nucleoporin p54 (NUP54)	OTHOIRMG	NUP54_HUMAN	Decreases Expression	[9]
Low-density lipoprotein receptor-related protein 10 (LRP10)	OT8490HT	LRP10_HUMAN	Increases Expression	[27]
Centromere protein V (CENPV)	OTPQ0KT9	CENPV_HUMAN	Increases Expression	[9]
RNA-binding Raly-like protein (RALYL)	OT232N7Q	RALYL_HUMAN	Increases Expression	[9]
THO complex subunit 4 (ALYREF)	OTOF2ADD	THOC4_HUMAN	Decreases Expression	[9]
GRIP and coiled-coil domain-containing protein 2 (GCC2)	OTT5I9FM	GCC2_HUMAN	Decreases Expression	[9]
Cell division cycle and apoptosis regulator protein 1 (CCAR1)	OTUXLQZZ	CCAR1_HUMAN	Increases Expression	[9]
NAD-dependent protein deacetylase sirtuin-2 (SIRT2)	OT5Q6SVK	SIR2_HUMAN	Increases Expression	[27]
Diacylglycerol lipase-beta (DAGLB)	OT1S9869	DGLB_HUMAN	Increases Expression	[27]
Paraneoplastic antigen Ma1 (PNMA1)	OTEUG8RL	PNMA1_HUMAN	Increases Expression	[9]
Diphosphoinositol polyphosphate phosphohydrolase 3-alpha (NUDT10)	OT61XMYC	NUD10_HUMAN	Increases Expression	[9]
Nuclear protein localization protein 4 homolog (NPLOC4)	OTC1WUVF	NPL4_HUMAN	Decreases Expression	[9]
TBC1 domain family member 15 (TBC1D15)	OTIT3Y14	TBC15_HUMAN	Increases Expression	[27]
PEST proteolytic signal-containing nuclear protein (PCNP)	OTJUQ122	PCNP_HUMAN	Increases Expression	[9]
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 (DHX38)	OTBVB3W5	PRP16_HUMAN	Decreases Expression	[9]
Nectin-2 (NECTIN2)	OTIE0W6O	NECT2_HUMAN	Decreases Expression	[9]
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 (ATP2A3)	OTFYDEES	AT2A3_HUMAN	Increases Expression	[9]
Major histocompatibility complex class I-related gene protein (MR1)	OTZU3XX7	HMR1_HUMAN	Affects Expression	[50]
Liver-expressed antimicrobial peptide 2 (LEAP2)	OTUOPIS5	LEAP2_HUMAN	Increases Expression	[28]
DNA topoisomerase I, mitochondrial (TOP1MT)	OT2H77ID	TOP1M_HUMAN	Increases Expression	[9]
PAT complex subunit CCDC47 (CCDC47)	OTUIN61P	CCD47_HUMAN	Increases Expression	[9]
Far upstream element-binding protein 1 (FUBP1)	OT77SC9N	FUBP1_HUMAN	Increases Expression	[9]
SH3 domain-containing kinase-binding protein 1 (SH3KBP1)	OTIUA60B	SH3K1_HUMAN	Increases Expression	[9]
ADP-ribosylation factor-like protein 8A (ARL8A)	OTEYM6FA	ARL8A_HUMAN	Decreases Expression	[9]
Protein phosphatase 1 regulatory subunit 14B (PPP1R14B)	OT9PTWAX	PP14B_HUMAN	Decreases Expression	[9]
BTB/POZ domain-containing protein KCTD12 (KCTD12)	OTPYKT4Z	KCD12_HUMAN	Decreases Expression	[9]
Small ribosomal subunit protein mS39 (PTCD3)	OTHTOLE0	PTCD3_HUMAN	Increases Expression	[9]
PDZ and LIM domain protein 5 (PDLIM5)	OTLQVV22	PDLI5_HUMAN	Decreases Expression	[9]
Serine/threonine-protein phosphatase PGAM5, mitochondrial (PGAM5)	OT6Q5M0C	PGAM5_HUMAN	Decreases Expression	[9]
Glutamate decarboxylase 1 (GAD1)	OT52Z39J	DCE1_HUMAN	Increases Expression	[48]
Proteasome subunit beta type-7 (PSMB7)	OT2NKD2K	PSB7_HUMAN	Decreases Expression	[9]
3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10)	OT7RJON4	HCD2_HUMAN	Decreases Expression	[9]
Nucleosome assembly protein 1-like 4 (NAP1L4)	OTUEG3QY	NP1L4_HUMAN	Increases Expression	[9]
Transmembrane 9 superfamily member 2 (TM9SF2)	OTA0C202	TM9S2_HUMAN	Decreases Expression	[9]
Copine-1 (CPNE1)	OTH5YKSL	CPNE1_HUMAN	Decreases Expression	[9]
T-complex protein 1 subunit eta (CCT7)	OTQNM3CY	TCPH_HUMAN	Decreases Expression	[9]
Protein arginine N-methyltransferase 1 (PRMT1)	OTN8GTXW	ANM1_HUMAN	Decreases Expression	[9]
Endophilin-A2 (SH3GL1)	OTXTBFWT	SH3G1_HUMAN	Increases Expression	[9]
Growth/differentiation factor 15 (GDF15)	OTWQN50N	GDF15_HUMAN	Increases Expression	[27]
Condensin complex subunit 3 (NCAPG)	OT1AI9EO	CND3_HUMAN	Increases Expression	[9]
Myb-binding protein 1A (MYBBP1A)	OTIVEMIU	MBB1A_HUMAN	Increases Expression	[9]
Coronin-1B (CORO1B)	OT7C4BMQ	COR1B_HUMAN	Decreases Expression	[9]
Histone H2A.J (H2AJ)	OTVA4XTW	H2AJ_HUMAN	Increases Expression	[9]
MKI67 FHA domain-interacting nucleolar phosphoprotein (NIFK)	OT20GHN3	MK67I_HUMAN	Decreases Expression	[9]
Fibroblast growth factor-binding protein 2 (FGFBP2)	OT3NBPQO	FGFP2_HUMAN	Increases Expression	[28]
Apoptosis facilitator Bcl-2-like protein 14 (BCL2L14)	OT87E7HW	B2L14_HUMAN	Decreases Expression	[9]
Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)	OTUYHB84	MLP3B_HUMAN	Increases Lipidation	[27]
RNA cytidine acetyltransferase (NAT10)	OT6JQO26	NAT10_HUMAN	Decreases Expression	[9]
Growth hormone-inducible transmembrane protein (GHITM)	OTBPNIC0	GHITM_HUMAN	Increases Expression	[9]
Damage-control phosphatase ARMT1 (ARMT1)	OTS7WBCP	ARMT1_HUMAN	Increases Expression	[9]
Exosome complex component RRP41 (EXOSC4)	OTG4TICP	EXOS4_HUMAN	Increases Expression	[9]
Synembryn-A (RIC8A)	OT4YZOWE	RIC8A_HUMAN	Decreases Expression	[9]
Kinesin-like protein KIF13B (KIF13B)	OTAFS1YV	KI13B_HUMAN	Increases Expression	[9]
Serine incorporator 1 (SERINC1)	OTF3UASX	SERC1_HUMAN	Increases Expression	[27]
Phenylalanine--tRNA ligase beta subunit (FARSB)	OT8N9TT5	SYFB_HUMAN	Increases Expression	[9]
ATPase family AAA domain-containing protein 3A (ATAD3A)	OTWF6HBP	ATD3A_HUMAN	Decreases Expression	[9]
Endoplasmic reticulum aminopeptidase 1 (ERAP1)	OT72S99B	ERAP1_HUMAN	Decreases Expression	[9]
Methionine adenosyltransferase 2 subunit beta (MAT2B)	OT4Y7T9L	MAT2B_HUMAN	Decreases Expression	[9]
Very-long-chain (HACD3)	OTISMCAF	HACD3_HUMAN	Increases Expression	[9]
Calcium-binding and coiled-coil domain-containing protein 1 (CALCOCO1)	OT1PAIN0	CACO1_HUMAN	Increases Expression	[27]
Ribosome-binding protein 1 (RRBP1)	OT4ZTPTM	RRBP1_HUMAN	Decreases Expression	[9]
Ataxin-10 (ATXN10)	OTKRDUNN	ATX10_HUMAN	Increases Expression	[9]
Tumor necrosis factor receptor superfamily member 10D (TNFRSF10D)	OTOSRDJT	TR10D_HUMAN	Increases Expression	[27]
DnaJ homolog subfamily B member 11 (DNAJB11)	OTDDK2SY	DJB11_HUMAN	Increases Expression	[9]
Testin (TES)	OTL8PP6V	TES_HUMAN	Decreases Expression	[9]
Translocation protein SEC63 homolog (SEC63)	OT1ICPMK	SEC63_HUMAN	Increases Expression	[9]
Cysteine and histidine-rich domain-containing protein 1 (CHORDC1)	OT3W6F1U	CHRD1_HUMAN	Increases Expression	[9]
NADH-cytochrome b5 reductase 1 (CYB5R1)	OTMDHMLA	NB5R1_HUMAN	Increases Expression	[9]
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial (SLC25A13)	OTTZVSK6	S2513_HUMAN	Increases Expression	[9]
Nuclear pore complex protein Nup50 (NUP50)	OTOZ98K3	NUP50_HUMAN	Increases Expression	[9]
Serine/threonine-protein kinase TAO2 (TAOK2)	OTNUMOZ1	TAOK2_HUMAN	Increases Expression	[9]
Sorting nexin-6 (SNX6)	OTLKQYJU	SNX6_HUMAN	Increases Expression	[9]
Translocon-associated protein subunit gamma (SSR3)	OTJQP0IZ	SSRG_HUMAN	Decreases Expression	[9]
DNA-binding protein SATB2 (SATB2)	OT2W80XC	SATB2_HUMAN	Increases Expression	[9]
Serine/arginine repetitive matrix protein 2 (SRRM2)	OTSIMMC9	SRRM2_HUMAN	Decreases Expression	[9]
Phenylalanine--tRNA ligase alpha subunit (FARSA)	OT3U1P20	SYFA_HUMAN	Increases Expression	[9]
Fanconi-associated nuclease 1 (FAN1)	OT1LM1HZ	FAN1_HUMAN	Increases Expression	[9]
Kelch domain-containing protein 2 (KLHDC2)	OTBHH882	KLDC2_HUMAN	Decreases Expression	[9]
Thyroid hormone receptor-associated protein 3 (THRAP3)	OTG25JOG	TR150_HUMAN	Decreases Expression	[9]
Serine-threonine kinase receptor-associated protein (STRAP)	OTT3T7QT	STRAP_HUMAN	Decreases Expression	[9]
RNA-splicing ligase RtcB homolog (RTCB)	OTUED31V	RTCB_HUMAN	Increases Expression	[9]
Nucleolar complex protein 2 homolog (NOC2L)	OTNT7R33	NOC2L_HUMAN	Increases Expression	[9]
TRPM8 channel-associated factor 1 (TCAF1)	OTSQQ37P	TCAF1_HUMAN	Decreases Expression	[9]
Talin-2 (TLN2)	OT10QQBC	TLN2_HUMAN	Decreases Expression	[9]
Beta-secretase 2 (BACE2)	OTO5YQVK	BACE2_HUMAN	Increases Expression	[27]
FH1/FH2 domain-containing protein 1 (FHOD1)	OTROM7N3	FHOD1_HUMAN	Decreases Expression	[9]
Chloride intracellular channel protein 4 (CLIC4)	OT6KTPKD	CLIC4_HUMAN	Increases Expression	[9]
Cytoplasmic dynein 1 light intermediate chain 1 (DYNC1LI1)	OTJUR82A	DC1L1_HUMAN	Decreases Expression	[9]
Nuclear factor erythroid 2-related factor 2 (NFE2L2)	OT0HENJ5	NF2L2_HUMAN	Affects Response To Substance	[51]
Flavin-containing monooxygenase 3 (FMO3)	OT1G2EV3	FMO3_HUMAN	Increases Metabolism	[52]
Sodium-dependent dopamine transporter (SLC6A3)	OT39XG28	SC6A3_HUMAN	Affects Response To Substance	[53]
Disrupted in schizophrenia 1 protein (DISC1)	OT43AW4H	DISC1_HUMAN	Decreases Response To Substance	[54]
Oxytocin-neurophysin 1 (OXT)	OT48M72Z	NEU1_HUMAN	Affects Response To Substance	[55]
Tumor necrosis factor (TNF)	OT4IE164	TNFA_HUMAN	Affects Response To Substance	[56]
Leptin (LEP)	OT5Q7ODW	LEP_HUMAN	Affects Response To Substance	[57]
Sodium-dependent serotonin transporter (SLC6A4)	OT6FGDLW	SC6A4_HUMAN	Affects Response To Substance	[58]
5-hydroxytryptamine receptor 2C (HTR2C)	OT6H8DE0	5HT2C_HUMAN	Affects Response To Substance	[59]
Dysbindin (DTNBP1)	OT9UQT2S	DTBP1_HUMAN	Increases Response To Substance	[60]
Glutathione S-transferase A1 (GSTA1)	OTA7K5XA	GSTA1_HUMAN	Decreases Activity	[61]
5-hydroxytryptamine receptor 3A (HTR3A)	OTAIV1AK	5HT3A_HUMAN	Affects Response To Substance	[62]
Ribosyldihydronicotinamide dehydrogenase (NQO2)	OTGDAJRZ	NQO2_HUMAN	Increases Reduction	[63]
Cytochrome P450 2J2 (CYP2J2)	OTJBTEH8	CP2J2_HUMAN	Increases Metabolism	[52]
D(1A) dopamine receptor (DRD1)	OTLZPBT7	DRD1_HUMAN	Affects Response To Substance	[64]
Circadian locomoter output cycles protein kaput (CLOCK)	OTNEOJY7	CLOCK_HUMAN	Affects Response To Substance	[65]
Catechol O-methyltransferase (COMT)	OTPWKTQG	COMT_HUMAN	Increases Response To Substance	[66]
Glutathione S-transferase Mu 1 (GSTM1)	OTSBF2MO	GSTM1_HUMAN	Decreases Activity	[61]
Cytochrome P450 3A5 (CYP3A5)	OTSXFBXB	CP3A5_HUMAN	Increases Metabolism	[52]
Flavin-containing monooxygenase 1 (FMO1)	OTTHSQKP	FMO1_HUMAN	Increases Metabolism	[52]
Methylenetetrahydrofolate reductase (MTHFR)	OTUBJSR7	MTHR_HUMAN	Affects Response To Substance	[67]
Synaptosomal-associated protein 25 (SNAP25)	OTUIQ81Q	SNP25_HUMAN	Affects Response To Substance	[68]
5-hydroxytryptamine receptor 2A (HTR2A)	OTWXJX0M	5HT2A_HUMAN	Increases Response To Substance	[69]

Indication(s) of Cycloserine

Disease Entry	ICD 11	Status	REF
Bacterial infection	1A00-1C4Z	Approved	[4]
Pulmonary tuberculosis	1B10.Z	Approved	[5]
Tuberculosis	1B10-1B14	Approved	[6]
Obsessive compulsive disorder	6B20	Phase 2	[4]

Cycloserine Interacts with 4 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Mycobacterium D-alanine-D-alanine ligase A (MycB ddl)	TTCS3P1	DDL_MYCTU	Inhibitor	[70]
Mycobacterium Biosynthetic alanine racemase (MycB alr)	TT6TMZU	ALR_MYCSM	Inhibitor	[71]
Glutamate receptor ionotropic NMDA 1 (NMDAR1)	TTLD29N	NMDZ1_HUMAN	Inhibitor	[71]
N-methyl-D-aspartate receptor (NMDAR)	TT9IK2Z	NOUNIPROTAC	Agonist	[72]

Cycloserine Interacts with 2 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
Proton-coupled amino acid transporter 1 (SLC36A1)	DT48WEM	S36A1_HUMAN	Substrate	[73]
Proton-coupled amino acid transporter 2 (SLC36A2)	DTAOPTV	S36A2_HUMAN	Substrate	[74]

References

• [1] ClinicalTrials.gov (NCT00000372) Glycine and D-Cycloserine in Schizophrenia
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 38).
• [3] Clozapine FDA Label
• [4] Has nature already identified all useful antibacterial targets Curr Opin Microbiol. 2008 Oct;11(5):387-92.
• [5] Cycloserine FDA Label
• [6] Novel agents in the management of Mycobacterium tuberculosis disease. Curr Med Chem. 2007;14(18):2000-8.
• [7] A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system. Toxicol Sci. 2005 Feb;83(2):282-92.
• [8] Markers of electrophilic stress caused by chemically reactive metabolites in human hepatocytes. Drug Metab Dispos. 2008 May;36(5):816-23.
• [9] Cannabidiol Displays Proteomic Similarities to Antipsychotics in Cuprizone-Exposed Human Oligodendrocytic Cell Line MO3.13. Front Mol Neurosci. 2021 May 28;14:673144. doi: 10.3389/fnmol.2021.673144. eCollection 2021.
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