Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMN6L70)

• Drug Name: Nitrobenzanthrone Drug Info
• Synonyms: 3-Nitrobenzanthrone; LS-27953; O4OJW7BC7W; QAJOWHGESRCVLY-UHFFFAOYSA-N; SCHEMBL7168071; ZINC4370589; 17117-34-9; 3-Nitro-7H-benz(de)anthracen-7-one; 3-Nitro-7H-benzo[d,e]anthracen-7-one; 3-Nitrobenzantrone; 3-nitro-7H-benzo[de]anthracen-7-one; 3-nitrobenzo[b]phenalen-7-one; 7H-Benz(de)anthracen-7-one, 3-nitro-; AC1MCTJK; ACM17117349; CCRIS 9003; DTXSID60881271; FT-0710181; UNII-O4OJW7BC7W
• Cross-matching ID:
  PubChem CID: 2825690
  CAS Number: CAS 17117-34-9
  TTD Drug ID: DMN6L70
  INTEDE Drug ID: DR0010

Molecule-Related Drug Atlas

Drug(s) Metabolized By Quinone reductase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[4]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[5]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[5]
Carboplatin	DMG281S	Adenocarcinoma	2D40	Approved	[5]
Beta-Lapachone	DMMI84K	Solid tumour/cancer	2A00-2F9Z	Phase 2	[6]
CB1954	DMVP4YK	Solid tumour/cancer	2A00-2F9Z	Discontinued in Phase 2	[7]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[8]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[9]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[10]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[11]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[12]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[13]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[14]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[15]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[16]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[17]

Drug(s) Affected By Ladinin-1 (LAD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[18]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[24]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[25]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[26]

Drug(s) Affected By Integrin beta-1-binding protein 1 (ITGB1BP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Heroin diacetylmorphine	DMDBWHY	Neurological disorder	6B60	Approved	[29]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[30]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[31]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[32]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[33]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[34]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[34]

Drug(s) Affected By Neuropilin-1 (NRP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[35]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[36]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[37]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[38]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[40]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]

Drug(s) Affected By Interferon regulatory factor 6 (IRF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[40]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[46]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[45]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[47]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[34]

Drug(s) Affected By Proepiregulin (EREG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[49]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[50]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[50]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[50]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[36]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[19]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[38]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[50]

Drug(s) Affected By Semaphorin-3E (SEMA3E)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[24]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[54]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[56]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[57]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[40]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[33]

Drug(s) Affected By Claudin-3 (CLDN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Guanfacine extended release	DMB1CZ8	Attention deficit hyperactivity disorder	6A05.Z	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[59]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[60]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[61]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[51]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[62]

Drug(s) Affected By Kunitz-type protease inhibitor 1 (SPINT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[65]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[57]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[67]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[69]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[70]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 12 (TNFSF12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[71]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[72]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[73]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[74]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[54]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[75]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[46]
Diphenylpyraline	DMW4X37	Allergic rhinitis	CA08.0	Approved	[76]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[77]

Drug(s) Affected By Zinc finger protein SNAI2 (SNAI2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]

Drug(s) Affected By Integral membrane protein 2A (ITM2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[82]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[84]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[85]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[82]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[86]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[87]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[88]

Drug(s) Affected By Periplakin (PPL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[40]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[19]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[90]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[91]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[92]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]

Drug(s) Affected By Neuropilin-2 (NRP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[24]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[73]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[95]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[40]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[40]

Drug(s) Affected By Gremlin-1 (GREM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[97]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[54]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[25]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[61]

Drug(s) Affected By Receptor activity-modifying protein 2 (RAMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[99]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[100]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[25]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[101]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[102]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[103]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[104]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[69]

Drug(s) Affected By TOM1-like protein 1 (TOM1L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[105]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[25]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[88]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[106]

Drug(s) Affected By Fibroblast growth factor 18 (FGF18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[108]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[90]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[25]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[109]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[32]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]

Drug(s) Affected By Slit homolog 2 protein (SLIT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[40]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[24]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[54]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[111]

Drug(s) Affected By Unconventional myosin-Id (MYO1D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[40]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[34]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[102]

Drug(s) Affected By Cyclin-dependent kinase 14 (CDK14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[54]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[88]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[113]
Geldanamycin	DMS7TC5	Kidney cancer	2C90.0	Discontinued in Phase 2	[114]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[106]

Drug(s) Affected By Tight junction protein ZO-3 (TJP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[36]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[115]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[116]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[26]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]

Drug(s) Affected By C-X-C motif chemokine 14 (CXCL14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[114]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[90]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[117]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[118]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Indomethacin	DMSC4A7	Bursitis		Approved	[119]

Drug(s) Affected By 2'-5'-oligoadenylate synthase 1 (OAS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[120]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[121]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[120]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[122]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[123]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[124]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[125]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[126]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[127]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[50]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[11]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[50]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[128]
Selenium	DM25CGV	N. A.	N. A.	Approved	[129]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[130]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[131]

Drug(s) Affected By Apolipoprotein E (APOE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[132]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[133]
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[19]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[134]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[38]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[135]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]

Drug(s) Affected By Angiogenin (ANG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[19]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[91]
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[138]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[25]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[26]
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[139]

Drug(s) Affected By HLA class II histocompatibility antigen, DP beta 1 chain (HLA-DPB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[140]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[122]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[142]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[143]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[105]
Bortezomib	DMNO38U	Leukemia		Approved	[60]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[144]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[46]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[145]

Drug(s) Affected By Receptor tyrosine-protein kinase erbB-2 (ERBB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trastuzumab	DMZQOUX	Breast cancer	2C60-2C65	Approved	[146]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[147]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[148]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[149]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[150]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[151]
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[36]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[152]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[153]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[99]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[154]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[155]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[156]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[157]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[158]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[159]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[160]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[161]

Drug(s) Affected By Integrin beta-3 (ITGB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[162]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[163]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[164]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[165]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[166]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[167]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[168]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[56]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[169]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[120]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[170]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[171]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[172]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[173]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[126]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[128]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[175]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[120]

Drug(s) Affected By Collagen alpha-2(V) chain (COL5A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[122]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[40]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[124]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[176]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[111]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[177]

Drug(s) Affected By Thrombospondin-1 (THBS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[35]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[99]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[178]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[120]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[180]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[181]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[65]

Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[182]
Selenium	DM25CGV	N. A.	N. A.	Approved	[183]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[184]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[185]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[186]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[187]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[122]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[188]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[189]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[190]

Drug(s) Affected By Inhibin beta A chain (INHBA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[100]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[124]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[191]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[111]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[92]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[192]

Drug(s) Affected By Hepatocyte growth factor receptor (MET)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cabozantinib	DMIYDT4	Medullary thyroid gland carcinoma		Approved	[193]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[194]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[50]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[50]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[50]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[120]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[19]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[50]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[195]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[120]

Drug(s) Affected By Keratin, type II cytoskeletal 7 (KRT7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[196]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[197]
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[180]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[198]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[199]

Drug(s) Affected By Fibroblast growth factor 2 (FGF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[200]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[196]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[201]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[202]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[203]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[204]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[135]
Isradipine	DMA5XGH	Hypertension	BA00-BA04	Approved	[205]
Valdecoxib	DMAY7H4	Osteoarthritis	FA00-FA05	Approved	[206]

Drug(s) Affected By Serglycin (SRGN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[114]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[207]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[199]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[54]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[208]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[209]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[25]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[210]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[211]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[212]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[172]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[213]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[126]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[50]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[11]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[214]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[50]

Drug(s) Affected By Serum response factor (SRF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[151]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[100]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[109]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[106]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[110]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[215]

Drug(s) Affected By Collagen alpha-1(VI) chain (COL6A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[180]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[167]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[216]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[180]

Drug(s) Affected By Bone morphogenetic protein 4 (BMP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[171]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[35]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[151]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[40]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[218]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[197]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[78]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[219]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[220]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[221]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[19]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[222]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[223]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[40]

Drug(s) Affected By Homeobox protein Hox-B3 (HOXB3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[224]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[54]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[95]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[119]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[109]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[225]
EPZ-004777	DMLN4V5	leukaemia	2A60-2B33	Investigative	[226]

Drug(s) Affected By Amphiregulin (AREG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[171]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[227]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[228]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[224]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[52]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[230]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[231]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[65]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[232]

Drug(s) Affected By Transcription factor 4 (TCF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[233]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[234]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[235]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[233]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[124]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[236]

Drug(s) Affected By Epithelial cell adhesion molecule (EPCAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[237]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[40]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[238]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[54]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[216]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[25]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[239]

Drug(s) Affected By Follistatin (FST)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[126]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[240]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[38]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[241]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[54]

Drug(s) Affected By Neurofibromin (NF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[106]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[242]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[40]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[242]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]

Drug(s) Affected By Fibroblast growth factor receptor 2 (FGFR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[201]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[243]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[235]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[244]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[244]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]

Drug(s) Affected By Insulin-like growth factor-binding protein 4 (IGFBP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[149]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[224]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[122]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[245]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[65]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[246]

Drug(s) Affected By Nuclear receptor subfamily 4immunitygroup A member 1 (NR4A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[247]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[228]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[100]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[248]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Febuxostat	DMDEXQ0	Hyperuricaemia	5C55.Y	Approved	[249]

Drug(s) Affected By Fibulin-1 (FBLN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[120]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[120]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[122]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[250]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]

Drug(s) Affected By Tenascin (TNC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[201]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[99]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[17]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[17]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[251]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[28]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[252]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[90]

Drug(s) Affected By Signal transducer CD24 (CD24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[247]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[224]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[253]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[254]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[40]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[54]

Drug(s) Affected By Pentraxin-related protein PTX3 (PTX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[255]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[199]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[94]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[117]
Bortezomib	DMNO38U	Leukemia		Approved	[256]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[257]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[258]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[259]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[260]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[261]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[262]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[263]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[264]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[265]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[266]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[267]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[258]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[268]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[269]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[270]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[257]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[146]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[125]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[260]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[261]

Drug(s) Affected By Hematopoietic progenitor cell antigen CD34 (CD34)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[271]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[122]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[272]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[72]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[90]
Omacetaxine mepesuccinate	DMPU2WX	Adult acute monocytic leukemia		Approved	[272]
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[139]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[67]
Napabucasin	DMDZ6Q3	Colorectal cancer	2B91.Z	Phase 3	[273]

Drug(s) Affected By Fibroblast growth factor 9 (FGF9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[274]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[90]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[94]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[275]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[276]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[95]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[277]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[278]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[151]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[279]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[280]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[187]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[281]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[282]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[283]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[284]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[285]

Drug(s) Affected By Thrombospondin-2 (THBS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[247]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[286]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[40]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[287]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[8]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[94]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[54]

Drug(s) Affected By Vascular endothelial growth factor receptor 3 (FLT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[280]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[288]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[289]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[290]
PMID25656651-Compound-5	DMAI95U	Chronic myeloid leukaemia	2A20	Patented	[291]
Scriptaid	DM9JZ21	Solid tumour/cancer	2A00-2F9Z	Preclinical	[292]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[293]

Drug(s) Affected By Collagen alpha-1(XVIII) chain (COL18A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[294]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[90]

Drug(s) Affected By Signal transducer and activator of transcription 3 (STAT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[146]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[125]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[295]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[296]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[297]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[298]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[224]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[299]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[300]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[301]

Drug(s) Affected By Interleukin-15 (IL15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[49]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[100]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[302]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[199]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[303]
Bortezomib	DMNO38U	Leukemia		Approved	[60]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[85]

Drug(s) Affected By Signal transducer and activator of transcription 1-alpha/beta (STAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[247]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[304]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[120]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[305]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[306]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[307]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[308]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[120]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[124]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]

Drug(s) Affected By ETS translocation variant 4 (ETV4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[224]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[100]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[124]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[251]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[90]
Bortezomib	DMNO38U	Leukemia		Approved	[60]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[25]

Drug(s) Affected By Transcription factor SOX-9 (SOX9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[196]
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[38]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[309]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[40]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[65]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[310]

Drug(s) Affected By Lumican (LUM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[98]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[191]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[94]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[111]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[46]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[311]

Drug(s) Affected By Integrin alpha-1 (ITGA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[312]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[90]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[313]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[314]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[67]

Drug(s) Affected By Glucose-6-phosphate exchanger SLC37A1 (SLC37A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[315]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[90]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[316]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
3-iodothyronamine	DM3L0F8	Discovery agent	N.A.	Investigative	[317]

Drug(s) Affected By Junctional adhesion molecule B (JAM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[196]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[318]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[111]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[95]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[319]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[289]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[320]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[321]

Drug(s) Affected By C-X-C chemokine receptor type 4 (CXCR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[197]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[120]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[280]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[322]
Carfilzomib	DM48K0X	Multiple myeloma	2A83	Approved	[323]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[120]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[324]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[325]

Drug(s) Affected By Insulin gene enhancer protein ISL-1 (ISL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[326]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[327]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[95]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[40]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[145]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[67]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]

Drug(s) Affected By Protein BTG1 (BTG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[328]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[329]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[330]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[181]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[207]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[329]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[199]

Drug(s) Affected By Forkhead box protein O4 (FOXO4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[331]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[332]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[117]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[333]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[109]

Drug(s) Affected By Peripheral myelin protein 22 (PMP22)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[111]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[334]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[335]

Drug(s) Affected By DNA-binding protein inhibitor ID-2 (ID2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[336]
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[337]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[19]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[338]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[339]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[242]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[235]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[337]

Drug(s) Affected By Desmocollin-2 (DSC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[122]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[40]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[24]

Drug(s) Affected By Caveolin-1 (CAV1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[340]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[35]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[264]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[341]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[342]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[84]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[343]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]

Drug(s) Affected By Interleukin-18 (IL18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[125]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[151]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[99]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[344]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[345]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[346]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[165]
Dihydroartemisinin	DMBXVMZ	Malaria	1F40-1F45	Approved	[347]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[165]

Drug(s) Affected By Serine/threonine-protein kinase N1 (PKN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[331]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[25]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[66]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[95]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[331]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[316]

Drug(s) Affected By Extracellular matrix protein 1 (ECM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[100]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[44]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[90]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[54]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[102]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[69]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[215]

Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[348]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[228]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[349]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[32]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[350]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[351]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[352]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[353]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[354]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[172]

Drug(s) Affected By Discoidin domain-containing receptor 2 (DDR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[355]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[145]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[54]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[320]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[356]

Drug(s) Affected By Zinc finger protein SNAI3 (SNAI3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[74]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[357]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[358]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
PMID27336223-Compound-5	DM6E50A	N. A.	N. A.	Patented	[74]

Drug(s) Affected By Growth/differentiation factor 6 (GDF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Indomethacin	DMSC4A7	Bursitis		Approved	[119]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[359]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[57]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[67]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
crotylaldehyde	DMTWRQI	Discovery agent	N.A.	Investigative	[360]

Drug(s) Affected By LLGL scribble cell polarity complex component 2 (LLGL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[90]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[361]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[362]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[363]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]

Drug(s) Affected By Collagen and calcium-binding EGF domain-containing protein 1 (CCBE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[364]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[365]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[54]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[366]
Maleic Acid	DM4L0R7	Discovery agent	N.A.	Investigative	[367]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[70]

Drug(s) Affected By Zinc finger protein basonuclin-2 (BNC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[196]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[114]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[54]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[111]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[368]

Drug(s) Affected By Protein ADM2 (ADM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[90]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[332]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[26]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[109]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[102]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[77]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]

Drug(s) Affected By Target of Nesh-SH3 (ABI3BP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[44]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[137]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[90]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[54]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[47]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[67]

Drug(s) Affected By Podoplanin (PDPN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[40]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[41]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[369]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[320]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[67]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[40]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[40]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[104]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]

Drug(s) Affected By Extracellular sulfatase Sulf-1 (SULF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[84]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[94]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[111]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[370]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[95]

Drug(s) Affected By Secreted frizzled-related protein 1 (SFRP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[286]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[371]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[124]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[372]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[373]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[73]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[191]

Drug(s) Affected By BMP-binding endothelial regulator protein (BMPER)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[43]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[75]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[40]
PDX-101	DM6OC53	Plasma cell myeloma	2A83.1	Phase 2	[40]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[374]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[366]

Drug(s) Affected By Liprin-beta-2 (PPFIBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[375]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[117]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[25]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[95]

Drug(s) Affected By Nesprin-1 (SYNE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[40]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[111]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]

Drug(s) Affected By Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[124]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[177]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[25]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[376]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[67]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[69]

Drug(s) Affected By Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2 (ARAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[40]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[377]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[199]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[91]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]

Drug(s) Affected By Protein NDRG1 (NDRG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[174]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[378]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[379]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[179]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[38]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[83]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[141]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[332]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[54]

Drug(s) Affected By Adhesion G protein-coupled receptor A2 (ADGRA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[122]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[311]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[40]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[380]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[381]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[382]

Drug(s) Affected By Metalloproteinase inhibitor 4 (TIMP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[183]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Isoproterenol	DMK7MEY	Atrioventricular block		Approved	[383]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[54]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[111]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[26]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[112]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[384]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[385]

Drug(s) Affected By Testican-3 (SPOCK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[24]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[25]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[386]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[374]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[70]

Drug(s) Affected By Chordin-like protein 1 (CHRDL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[114]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[111]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[46]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[145]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[34]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[88]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[104]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[374]

Drug(s) Affected By Homeodomain-interacting protein kinase 2 (HIPK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[38]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[65]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[74]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[54]

Drug(s) Affected By Protein bicaudal C homolog 1 (BICC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[368]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[67]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[387]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[366]

Drug(s) Affected By Tensin-1 (TNS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[19]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[42]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[74]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[25]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[45]

Drug(s) Affected By Unconventional myosin-Vc (MYO5C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[91]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[25]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[93]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[362]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[102]

Drug(s) Affected By Junctional cadherin 5-associated protein (JCAD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[95]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[109]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[40]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[40]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]

Drug(s) Affected By Fibulin-5 (FBLN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[235]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[90]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[94]
Bortezomib	DMNO38U	Leukemia		Approved	[60]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[388]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[67]

Drug(s) Affected By A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[38]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[389]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[135]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[390]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[107]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[90]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[111]

Drug(s) Affected By Apoptosis-associated speck-like protein containing a CARD (PYCARD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[125]
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[391]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[345]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[392]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[73]

Drug(s) Affected By Plexin-D1 (PLXND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[20]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[208]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[145]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[104]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[68]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[106]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[110]

Drug(s) Affected By Junctional adhesion molecule A (F11R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[110]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[64]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[21]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[23]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[393]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[55]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[394]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[395]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[396]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[11]
Selenium	DM25CGV	N. A.	N. A.	Approved	[63]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[397]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[14]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[15]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[19]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[398]

Drug(s) Affected By Sulfotransferase 1A1 (SULT1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[56]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[399]
Minoxidil	DMA2Z4F	Alopecia	ED70	Approved	[400]
Benzyl alcohol	DMBVYDI	Head and body lice	1G00.0	Approved	[401]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[400]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[402]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[364]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[403]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]

Drug(s) Affected By Sulfotransferase 1A2 (SULT1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzyl alcohol	DMBVYDI	Head and body lice	1G00.0	Approved	[401]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[19]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[27]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[40]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[135]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[53]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[24]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[25]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[56]

Drug(s) Affected By Arylamine N-acetyltransferase 2 (NAT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Procainamide	DMNMXR8	Ventricular arrhythmias	BC71	Approved	[404]
Hydralazine	DMU8JGH	Chronic heart failure	BD1Z	Approved	[405]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[406]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[407]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[408]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[409]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[410]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[70]

Drug(s) Affected By Arylamine N-acetyltransferase 1 (NAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Procainamide	DMNMXR8	Ventricular arrhythmias	BC71	Approved	[411]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[408]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[412]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[411]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[22]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[411]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[332]

Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[413]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[414]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[228]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[415]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[413]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[19]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[416]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[413]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[417]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[89]

Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[418]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[413]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[414]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[419]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[413]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[413]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[178]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[420]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[419]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[413]

Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[48]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[413]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[414]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[421]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[421]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[413]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[413]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[253]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[422]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[39]

Molecular Interaction Atlas of This Drug

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Quinone reductase 1 (NQO1) Main DME	DENP5RY	NQO1_HUMAN	Substrate	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
2'-5'-oligoadenylate synthase 1 (OAS1)	OT8ZLOCY	OAS1_HUMAN	Gene/Protein Processing	[2]
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[2]
A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1)	OTTLJH8W	ATS1_HUMAN	Gene/Protein Processing	[2]
Adhesion G protein-coupled receptor A2 (ADGRA2)	OTBT4W36	AGRA2_HUMAN	Gene/Protein Processing	[2]
Aldo-keto reductase family 1 member C1 (AKR1C1)	OTQKR4CM	AK1C1_HUMAN	Biotransformations	[3]
Aldo-keto reductase family 1 member C2 (AKR1C2)	OTQ2XMO3	AK1C2_HUMAN	Biotransformations	[3]
Aldo-keto reductase family 1 member C3 (AKR1C3)	OTU2SXBA	AK1C3_HUMAN	Biotransformations	[3]
Amphiregulin (AREG)	OTJFOR67	AREG_HUMAN	Gene/Protein Processing	[2]
Angiogenin (ANG)	OT3ECS6P	ANGI_HUMAN	Gene/Protein Processing	[2]
Apolipoprotein E (APOE)	OTFOWL2H	APOE_HUMAN	Gene/Protein Processing	[2]

References

• [1] Dose-dependent response to 3-nitrobenzanthrone exposure in human urothelial cancer cells. Chem Res Toxicol. 2017 Oct 16;30(10):1855-1864.
• [2] 3-Nitrobenzanthrone promotes malignant transformation in human lung epithelial cells through the epiregulin-signaling pathway. Cell Biol Toxicol. 2022 Oct;38(5):865-887. doi: 10.1007/s10565-021-09612-1. Epub 2021 May 25.
• [3] Role of Human Aldo-Keto Reductases in the Metabolic Activation of the Carcinogenic Air Pollutant 3-Nitrobenzanthrone. Chem Res Toxicol. 2018 Nov 19;31(11):1277-1288. doi: 10.1021/acs.chemrestox.8b00250. Epub 2018 Nov 8.
• [4] Differential ability of cytostatics from anthraquinone group to generate free radicals in three enzymatic systems: NADH dehydrogenase, NADPH cytochrome P450 reductase, and xanthine oxidase. Oncol Res. 2003;13(5):245-52.
• [5] PharmGKB: A worldwide resource for pharmacogenomic information. Wiley Interdiscip Rev Syst Biol Med. 2018 Jul;10(4):e1417. (ID: PA150642262)
• [6] Beta-lapachone, a modulator of NAD metabolism, prevents health declines in aged mice. PLoS One. 2012;7(10):e47122.
• [7] Gene Therapy of the Central Nervous System. Charter 22 - Prodrug-Activation Gene Therapy. 2006, Pages 291-301
• [8] Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
• [9] Functional cardiotoxicity assessment of cosmetic compounds using human-induced pluripotent stem cell-derived cardiomyocytes. Arch Toxicol. 2018 Jan;92(1):371-381.
• [10] Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Redox Biol. 2020 Jan;28:101321. doi: 10.1016/j.redox.2019.101321. Epub 2019 Sep 5.
• [11] Gypenosides protect retinal pigment epithelium cells from oxidative stress. Food Chem Toxicol. 2018 Feb;112:76-85.
• [12] Enhanced cytotoxicity of bioreductive antitumor agents with dimethyl fumarate in human glioblastoma cells. Anticancer Drugs. 2005 Feb;16(2):167-74.
• [13] Growth-suppressive effect of non-steroidal anti-inflammatory drugs on 11 colon-cancer cell lines and fluorescence differential display of genes whose expression is influenced by sulindac. Int J Cancer. 2000 Dec 15;88(6):873-80. doi: 10.1002/1097-0215(20001215)88:6<873::aid-ijc6>3.0.co;2-b.
• [14] Simvastatin protects dopaminergic neurons against MPP+-induced oxidative stress and regulates the endogenous anti-oxidant system through ERK. Cell Physiol Biochem. 2018;51(4):1957-1968.
• [15] P450 3A-catalyzed O-dealkylation of lapatinib induces mitochondrial stress and activates Nrf2. Chem Res Toxicol. 2016 May 16;29(5):784-96.
• [16] Induction of human NAD(P)H:quinone oxidoreductase (NQO1) gene expression by the flavonol quercetin. Toxicol Lett. 2001 Feb 3;119(1):49-57.
• [17] Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
• [18] p21(WAF1/cip1) is an important determinant of intestinal cell response to sulindac in vitro and in vivo. Cancer Res. 2001 Aug 15;61(16):6297-302.
• [19] Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
• [20] Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
• [21] Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
• [22] Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
• [23] Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
• [24] Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92. doi: 10.1016/j.bbrc.2011.08.027. Epub 2011 Aug 16.
• [25] Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
• [26] Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. PLoS One. 2012;7(12):e53003. doi: 10.1371/journal.pone.0053003. Epub 2012 Dec 27.
• [27] Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
• [28] Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
• [29] Distinctive profiles of gene expression in the human nucleus accumbens associated with cocaine and heroin abuse. Neuropsychopharmacology. 2006 Oct;31(10):2304-12. doi: 10.1038/sj.npp.1301089. Epub 2006 May 3.
• [30] NOTCH signaling is activated in and contributes to resistance in enzalutamide-resistant prostate cancer cells. J Biol Chem. 2019 May 24;294(21):8543-8554. doi: 10.1074/jbc.RA118.006983. Epub 2019 Apr 2.
• [31] Gene expression profile of the nucleus accumbens of human cocaine abusers: evidence for dysregulation of myelin. J Neurochem. 2004 Mar;88(5):1211-9. doi: 10.1046/j.1471-4159.2003.02247.x.
• [32] Gene expression in endometrial cancer cells (Ishikawa) after short time high dose exposure to progesterone. Steroids. 2008 Jan;73(1):116-28.
• [33] Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions. Toxicol In Vitro. 2009 Apr;23(3):466-75. doi: 10.1016/j.tiv.2008.12.018. Epub 2008 Dec 30.
• [34] Gene expression profiling of 30 cancer cell lines predicts resistance towards 11 anticancer drugs at clinically achieved concentrations. Int J Cancer. 2006 Apr 1;118(7):1699-712. doi: 10.1002/ijc.21570.
• [35] Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
• [36] Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
• [37] Quercetin induced cell apoptosis and altered gene expression in AGS human gastric cancer cells. Environ Toxicol. 2018 Nov;33(11):1168-1181. doi: 10.1002/tox.22623. Epub 2018 Aug 27.
• [38] Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
• [39] Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
• [40] A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
• [41] Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
• [42] Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
• [43] Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
• [44] Identification of vitamin D3 target genes in human breast cancer tissue. J Steroid Biochem Mol Biol. 2016 Nov;164:90-97.
• [45] Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
• [46] Blood transcript immune signatures distinguish a subset of people with elevated serum ALT from others given acetaminophen. Clin Pharmacol Ther. 2016 Apr;99(4):432-41.
• [47] Unique transcriptome, pathways, and networks in the human endometrial fibroblast response to progesterone in endometriosis. Biol Reprod. 2011 Apr;84(4):801-15.
• [48] Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
• [49] Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
• [50] An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
• [51] Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
• [52] Retinoid-induced epidermal hyperplasia is mediated by epidermal growth factor receptor activation via specific induction of its ligands heparin-binding EGF and amphiregulin in human skin in vivo. J Invest Dermatol. 2006 Apr;126(4):732-9. doi: 10.1038/sj.jid.5700202.
• [53] Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
• [54] Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
• [55] Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
• [56] Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
• [57] RNA sequence analysis of inducible pluripotent stem cell-derived cardiomyocytes reveals altered expression of DNA damage and cell cycle genes in response to doxorubicin. Toxicol Appl Pharmacol. 2018 Oct 1;356:44-53.
• [58] Palmitoylethanolamide and Cannabidiol Prevent Inflammation-induced Hyperpermeability of the Human Gut In Vitro and In Vivo-A Randomized, Placebo-controlled, Double-blind Controlled Trial. Inflamm Bowel Dis. 2019 May 4;25(6):1006-1018. doi: 10.1093/ibd/izz017.
• [59] Anti-invasive activity of sanguinarine through modulation of tight junctions and matrix metalloproteinase activities in MDA-MB-231 human breast carcinoma cells. Chem Biol Interact. 2009 May 15;179(2-3):185-91. doi: 10.1016/j.cbi.2008.11.009. Epub 2008 Nov 21.
• [60] The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
• [61] Chemical genomic screening for methylation-silenced genes in gastric cancer cell lines using 5-aza-2'-deoxycytidine treatment and oligonucleotide microarray. Cancer Sci. 2006 Jan;97(1):64-71.
• [62] Inorganic arsenic exposure promotes malignant progression by HDAC6-mediated down-regulation of HTRA1. J Appl Toxicol. 2023 Aug;43(8):1214-1224. doi: 10.1002/jat.4457. Epub 2023 Mar 11.
• [63] Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
• [64] Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
• [65] THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
• [66] Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
• [67] Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
• [68] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
• [69] Cell-based two-dimensional morphological assessment system to predict cancer drug-induced cardiotoxicity using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Appl Pharmacol. 2019 Nov 15;383:114761. doi: 10.1016/j.taap.2019.114761. Epub 2019 Sep 15.
• [70] From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
• [71] Survival of retinal pigment epithelium after exposure to prolonged oxidative injury: a detailed gene expression and cellular analysis. Invest Ophthalmol Vis Sci. 2004 Oct;45(10):3767-77.
• [72] Epigenetic activation of O-linked -N-acetylglucosamine transferase overrides the differentiation blockage in acute leukemia. EBioMedicine. 2020 Apr;54:102678. doi: 10.1016/j.ebiom.2020.102678. Epub 2020 Apr 6.
• [73] Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
• [74] PPARgamma controls CD1d expression by turning on retinoic acid synthesis in developing human dendritic cells. J Exp Med. 2006 Oct 2;203(10):2351-62.
• [75] Prenatal arsenic exposure and shifts in the newborn proteome: interindividual differences in tumor necrosis factor (TNF)-responsive signaling. Toxicol Sci. 2014 Jun;139(2):328-37. doi: 10.1093/toxsci/kfu053. Epub 2014 Mar 27.
• [76] Controlled diesel exhaust and allergen coexposure modulates microRNA and gene expression in humans: Effects on inflammatory lung markers. J Allergy Clin Immunol. 2016 Dec;138(6):1690-1700. doi: 10.1016/j.jaci.2016.02.038. Epub 2016 Apr 24.
• [77] CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer. J Clin Invest. 2016 Feb;126(2):639-52.
• [78] Manganese superoxide dismutase induces migration and invasion of tongue squamous cell carcinoma via H2O2-dependent Snail signaling. Free Radic Biol Med. 2012 Jul 1;53(1):44-50. doi: 10.1016/j.freeradbiomed.2012.04.031. Epub 2012 May 9.
• [79] Ciprofloxacin mediates cancer stem cell phenotypes in lung cancer cells through caveolin-1-dependent mechanism. Chem Biol Interact. 2016 Apr 25;250:1-11.
• [80] Endoplasmic reticulum stress contributes to arsenic trioxide-induced intrinsic apoptosis in human umbilical and bone marrow mesenchymal stem cells. Environ Toxicol. 2016 Mar;31(3):314-28.
• [81] Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
• [82] Gene expression profiling of rheumatoid arthritis synovial cells treated with antirheumatic drugs. J Biomol Screen. 2007 Apr;12(3):328-40. doi: 10.1177/1087057107299261. Epub 2007 Mar 22.
• [83] Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7653-8.
• [84] Changes in gene expression profiles of multiple myeloma cells induced by arsenic trioxide (ATO): possible mechanisms to explain ATO resistance in vivo. Br J Haematol. 2005 Mar;128(5):636-44.
• [85] Identification of biomarkers modulated by the rexinoid LGD1069 (bexarotene) in human breast cells using oligonucleotide arrays. Cancer Res. 2006 Dec 15;66(24):12009-18.
• [86] Identification of potential biomarkers of hepatitis B-induced acute liver failure using hepatic cells derived from human skin precursors. Toxicol In Vitro. 2015 Sep;29(6):1231-9. doi: 10.1016/j.tiv.2014.10.012. Epub 2014 Oct 24.
• [87] Identification of novel biomarkers for doxorubicin-induced toxicity in human cardiomyocytes derived from pluripotent stem cells. Toxicology. 2015 Feb 3;328:102-11. doi: 10.1016/j.tox.2014.12.018. Epub 2014 Dec 18.
• [88] Definition of transcriptome-based indices for quantitative characterization of chemically disturbed stem cell development: introduction of the STOP-Toxukn and STOP-Toxukk tests. Arch Toxicol. 2017 Feb;91(2):839-864.
• [89] The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
• [90] Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
• [91] A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo. Carcinogenesis. 2012 Jul;33(7):1421-9.
• [92] Differential expression of microRNAs and their predicted targets in renal cells exposed to amphotericin B and its complex with copper (II) ions. Toxicol Mech Methods. 2017 Sep;27(7):537-543. doi: 10.1080/15376516.2017.1333554. Epub 2017 Jun 8.
• [93] Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
• [94] Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.
• [95] Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
• [96] Unique signatures of stress-induced senescent human astrocytes. Exp Neurol. 2020 Dec;334:113466. doi: 10.1016/j.expneurol.2020.113466. Epub 2020 Sep 17.
• [97] Global effects of inorganic arsenic on gene expression profile in human macrophages. Mol Immunol. 2009 Feb;46(4):649-56.
• [98] Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
• [99] The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
• [100] Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
• [101] Frequent inactivation of RAMP2, EFEMP1 and Dutt1 in lung cancer by promoter hypermethylation. Clin Cancer Res. 2007 Aug 1;13(15 Pt 1):4336-44. doi: 10.1158/1078-0432.CCR-07-0015.
• [102] Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
• [103] Comprehensive transcriptome profiling of BET inhibitor-treated HepG2 cells. PLoS One. 2022 Apr 29;17(4):e0266966. doi: 10.1371/journal.pone.0266966. eCollection 2022.
• [104] Inhibition of BRD4 attenuates tumor cell self-renewal and suppresses stem cell signaling in MYC driven medulloblastoma. Oncotarget. 2014 May 15;5(9):2355-71.
• [105] Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons. PLoS One. 2009 Sep 23;4(9):e7155.
• [106] Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
• [107] Cyclosporine A--induced oxidative stress in human renal mesangial cells: a role for ERK 1/2 MAPK signaling. Toxicol Sci. 2012 Mar;126(1):101-13.
• [108] Design principles of concentration-dependent transcriptome deviations in drug-exposed differentiating stem cells. Chem Res Toxicol. 2014 Mar 17;27(3):408-20.
• [109] 17-Estradiol Activates HSF1 via MAPK Signaling in ER-Positive Breast Cancer Cells. Cancers (Basel). 2019 Oct 11;11(10):1533. doi: 10.3390/cancers11101533.
• [110] DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
• [111] Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
• [112] Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
• [113] Clarifying off-target effects for torcetrapib using network pharmacology and reverse docking approach. BMC Syst Biol. 2012 Dec 10;6:152.
• [114] Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. Arch Toxicol. 2016 Jan;90(1):159-80.
• [115] Gene microarray analysis of human renal cell carcinoma: the effects of HDAC inhibition and retinoid treatment. Cancer Biol Ther. 2008 Oct;7(10):1607-18.
• [116] Evidence for a role of claudin 2 as a proximal tubular stress responsive paracellular water channel. Toxicol Appl Pharmacol. 2014 Sep 1;279(2):163-72.
• [117] CXCL14 downregulation in human keratinocytes is a potential biomarker for a novel in vitro skin sensitization test. Toxicol Appl Pharmacol. 2020 Jan 1;386:114828. doi: 10.1016/j.taap.2019.114828. Epub 2019 Nov 14.
• [118] Re-expression of CXCL14, a common target for epigenetic silencing in lung cancer, induces tumor necrosis. Oncogene. 2010 Sep 16;29(37):5159-70. doi: 10.1038/onc.2010.255. Epub 2010 Jun 21.
• [119] Evaluation of developmental toxicity using undifferentiated human embryonic stem cells. J Appl Toxicol. 2015 Feb;35(2):205-18.
• [120] Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
• [121] Retinoic acid-induced downmodulation of telomerase activity in human cancer cells. Exp Mol Pathol. 2005 Oct;79(2):108-17.
• [122] Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
• [123] DNA array analysis of the effects of aspirin on colon cancer cells: involvement of Rac1. Carcinogenesis. 2004 Jul;25(7):1293-8.
• [124] Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
• [125] Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
• [126] ERE-independent ERalpha target genes differentially expressed in human breast tumors. Mol Cell Endocrinol. 2005 Dec 21;245(1-2):53-9. doi: 10.1016/j.mce.2005.10.003. Epub 2005 Nov 17.
• [127] Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction. J Toxicol Sci. 2020;45(11):673-680. doi: 10.2131/jts.45.673.
• [128] (9)-Tetrahydrocannabinol Suppresses Monocyte-Mediated Astrocyte Production of Monocyte Chemoattractant Protein 1 and Interleukin-6 in a Toll-Like Receptor 7-Stimulated Human Coculture. J Pharmacol Exp Ther. 2019 Oct;371(1):191-201. doi: 10.1124/jpet.119.260661. Epub 2019 Aug 5.
• [129] Changes in gene expression profiles in response to selenium supplementation among individuals with arsenic-induced pre-malignant skin lesions. Toxicol Lett. 2007 Mar 8;169(2):162-76. doi: 10.1016/j.toxlet.2007.01.006. Epub 2007 Jan 19.
• [130] Profiling the immunotoxicity of chemicals based on in vitro evaluation by a combination of the Multi-ImmunoTox assay and the IL-8 Luc assay. Arch Toxicol. 2018 Jun;92(6):2043-2054. doi: 10.1007/s00204-018-2199-7. Epub 2018 Mar 29.
• [131] Spironolactone induces apoptosis in human mononuclear cells. Association between apoptosis and cytokine suppression. Apoptosis. 2006 Apr;11(4):573-9. doi: 10.1007/s10495-006-4919-3.
• [132] Effects of rosiglitazone and atorvastatin on the expression of genes that control cholesterol homeostasis in differentiating monocytes. Biochem Pharmacol. 2006 Feb 28;71(5):605-14.
• [133] Tolerability of statins is not linked to CYP450 polymorphisms, but reduced CYP2D6 metabolism improves cholesteraemic response to simvastatin and fluvastatin. Pharmacol Res. 2007 Apr;55(4):310-7. doi: 10.1016/j.phrs.2006.12.009. Epub 2007 Jan 14.
• [134] Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
• [135] Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Toxicol Appl Pharmacol. 2012 Jun 1;261(2):204-16.
• [136] Biological specificity of CDK4/6 inhibitors: dose response relationship, in vivo signaling, and composite response signature. Oncotarget. 2017 Jul 4;8(27):43678-43691. doi: 10.18632/oncotarget.18435.
• [137] Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
• [138] Effects of enalapril maleate on blood pressure, renin-angiotensin-aldosterone system, and peripheral sympathetic activity in essential hypertension. Clin Ther. 1987;9(4):390-9.
• [139] Valsartan improves adipose tissue function in humans with impaired glucose metabolism: a randomized placebo-controlled double-blind trial. PLoS One. 2012;7(6):e39930. doi: 10.1371/journal.pone.0039930. Epub 2012 Jun 29.
• [140] The human leucocyte antigen-DRB1*1302-DQB1*0609-DPB1*0201 haplotype may be a strong genetic marker for aspirin-induced urticaria. Clin Exp Allergy. 2005 Mar;35(3):339-44. doi: 10.1111/j.1365-2222.2004.02197.x.
• [141] The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
• [142] The long-term impact of folic acid in pregnancy on offspring DNA methylation: follow-up of the Aberdeen Folic Acid Supplementation Trial (AFAST). Int J Epidemiol. 2018 Jun 1;47(3):928-937. doi: 10.1093/ije/dyy032.
• [143] Glucocorticoid regulation of human eosinophil gene expression. J Steroid Biochem Mol Biol. 2003 Mar;84(4):441-52. doi: 10.1016/s0960-0760(03)00065-7.
• [144] Transcriptomics and methylomics of CD4-positive T cells in arsenic-exposed women. Arch Toxicol. 2017 May;91(5):2067-2078. doi: 10.1007/s00204-016-1879-4. Epub 2016 Nov 12.
• [145] Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
• [146] ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
• [147] Cannabidiol and Oxygen-Ozone Combination Induce Cytotoxicity in Human Pancreatic Ductal Adenocarcinoma Cell Lines. Cancers (Basel). 2020 Sep 27;12(10):2774. doi: 10.3390/cancers12102774.
• [148] Down-regulation of HER-2 expression in human breast cancer cell HBC-4 and ZR75-1 by nitrogen-mustard-N-oxide. Kobe J Med Sci. 2007;53(4):135-42.
• [149] Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
• [150] Epidermal growth factor receptor activity determines response of colorectal cancer cells to gefitinib alone and in combination with chemotherapy. Clin Cancer Res. 2005 Oct 15;11(20):7480-9. doi: 10.1158/1078-0432.CCR-05-0328.
• [151] Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
• [152] Inhibition of prostate cancer cell colony formation by the flavonoid quercetin correlates with modulation of specific regulatory genes. Clin Diagn Lab Immunol. 2004 Jan;11(1):63-9. doi: 10.1128/cdli.11.1.63-69.2004.
• [153] p53-R175H mutant gains new function in regulation of doxorubicin-induced apoptosis. Int J Cancer. 2005 Apr 10;114(3):331-6. doi: 10.1002/ijc.20818.
• [154] Azidothymidine and cisplatin increase p14ARF expression in OVCAR-3 ovarian cancer cell line. Toxicol Appl Pharmacol. 2006 Oct 1;216(1):89-97. doi: 10.1016/j.taap.2006.04.015. Epub 2006 May 19.
• [155] Quantitative analysis of gene expression changes in response to genotoxic compounds. Toxicol In Vitro. 2017 Mar;39:15-28. doi: 10.1016/j.tiv.2016.11.004. Epub 2016 Nov 5.
• [156] Induction of apoptosis by cidofovir in human papillomavirus (HPV)-positive cells. Oncol Res. 2000;12(9-10):397-408. doi: 10.3727/096504001108747855.
• [157] Gallic acid potentiates the apoptotic effect of paclitaxel and carboplatin via overexpression of Bax and P53 on the MCF-7 human breast cancer cell line. J Biochem Mol Toxicol. 2021 Feb;35(2):e22638. doi: 10.1002/jbt.22638. Epub 2020 Oct 1.
• [158] Regulation of human dUTPase gene expression and p53-mediated transcriptional repression in response to oxaliplatin-induced DNA damage. Nucleic Acids Res. 2009 Jan;37(1):78-95. doi: 10.1093/nar/gkn910. Epub 2008 Nov 16.
• [159] Role of miRNA in the regulation of cannabidiol-mediated apoptosis in neuroblastoma cells. Oncotarget. 2019 Jan 1;10(1):45-59. doi: 10.18632/oncotarget.26534. eCollection 2019 Jan 1.
• [160] Nitrogen Mustard Alkylates and Cross-Links p53 in Human Keratinocytes. Chem Res Toxicol. 2022 Apr 18;35(4):636-650. doi: 10.1021/acs.chemrestox.1c00420. Epub 2022 Mar 21.
• [161] Fulvestrant induces resistance by modulating GPER and CDK6 expression: implication of methyltransferases, deacetylases and the hSWI/SNF chromatin remodelling complex. Br J Cancer. 2013 Nov 12;109(10):2751-62. doi: 10.1038/bjc.2013.583. Epub 2013 Oct 29.
• [162] Resistance in vitro to low-dose aspirin is associated with platelet PlA1 (GP IIIa) polymorphism but not with C807T(GP Ia/IIa) and C-5T Kozak (GP Ibalpha) polymorphisms. J Am Coll Cardiol. 2003 Sep 17;42(6):1115-9. doi: 10.1016/s0735-1097(03)00921-5.
• [163] Pro-apoptotic role of integrin 3 in glioma cells. J Neurochem. 2011 May;117(3):494-503. doi: 10.1111/j.1471-4159.2011.07219.x. Epub 2011 Mar 15.
• [164] In vitro dual effect of arsenic trioxide on hemopoiesis: inhibition of erythropoiesis and stimulation of megakaryocytic maturation. Blood Cells Mol Dis. 2006 Jan-Feb;36(1):59-76. doi: 10.1016/j.bcmd.2005.10.005. Epub 2005 Dec 15.
• [165] The differential cancer growth associated with anaesthetics in a cancer xenograft model of mice: mechanisms and implications of postoperative cancer recurrence. Cell Biol Toxicol. 2023 Aug;39(4):1561-1575. doi: 10.1007/s10565-022-09747-9. Epub 2022 Aug 12.
• [166] Grouping of histone deacetylase inhibitors and other toxicants disturbing neural crest migration by transcriptional profiling. Neurotoxicology. 2015 Sep;50:56-70.
• [167] Proteomic analysis of human adipose tissue after rosiglitazone treatment shows coordinated changes to promote glucose uptake. Obesity (Silver Spring). 2010 Jan;18(1):27-34. doi: 10.1038/oby.2009.208. Epub 2009 Jun 25.
• [168] Dose- and time-dependent transcriptional response of Ishikawa cells exposed to genistein. Toxicol Sci. 2016 May;151(1):71-87.
• [169] Progesterone regulation of implantation-related genes: new insights into the role of oestrogen. Cell Mol Life Sci. 2007 Apr;64(7-8):1009-32.
• [170] Mechanisms of dexamethasone-induced disturbed sleep and fatigue in paediatric patients receiving treatment for ALL. Eur J Cancer. 2010 Jul;46(10):1848-55. doi: 10.1016/j.ejca.2010.03.026. Epub 2010 Apr 17.
• [171] Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
• [172] Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x. Epub 2009 Apr 8.
• [173] Some HIV antiretrovirals increase oxidative stress and alter chemokine, cytokine or adiponectin production in human adipocytes and macrophages. Antivir Ther. 2007;12(4):489-500.
• [174] Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts. Biomed Res Int. 2015;2015:257090. doi: 10.1155/2015/257090. Epub 2015 Aug 3.
• [175] Blood cell oxidative stress precedes hemolysis in whole blood-liver slice co-cultures of rat, dog, and human tissues. Toxicol Appl Pharmacol. 2010 May 1;244(3):354-65. doi: 10.1016/j.taap.2010.01.017. Epub 2010 Feb 6.
• [176] Use of transcriptomics in hazard identification and next generation risk assessment: A case study with clothianidin. Food Chem Toxicol. 2022 Aug;166:113212. doi: 10.1016/j.fct.2022.113212. Epub 2022 Jun 8.
• [177] The genomic response of a human uterine endometrial adenocarcinoma cell line to 17alpha-ethynyl estradiol. Toxicol Sci. 2009 Jan;107(1):40-55.
• [178] Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer Sci. 2007 Jun;98(6):890-9.
• [179] Hypoxia-inducible factor-1 (HIF-1) pathway activation by quercetin in human lens epithelial cells. Exp Eye Res. 2009 Dec;89(6):995-1002. doi: 10.1016/j.exer.2009.08.011. Epub 2009 Sep 1.
• [180] Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
• [181] Expression profile analysis of human peripheral blood mononuclear cells in response to aspirin. Arch Immunol Ther Exp (Warsz). 2005 Mar-Apr;53(2):151-8.
• [182] Oxidative Stress-Protective and Anti-Melanogenic Effects of Loliolide and Ethanol Extract from Fresh Water Green Algae, Prasiola japonica. Int J Mol Sci. 2018 Sep 18;19(9):2825. doi: 10.3390/ijms19092825.
• [183] Inhibition of invasion and induction of apoptosis by selenium in human malignant brain tumour cells in vitro. Int J Oncol. 2007 May;30(5):1263-71.
• [184] Impaired migration of trophoblast cells caused by simvastatin is associated with decreased membrane IGF-I receptor, MMP2 activity and HSP27 expression. Hum Reprod. 2007 Apr;22(4):1161-7. doi: 10.1093/humrep/del464. Epub 2006 Dec 11.
• [185] Quercetin Suppresses the Migration and Invasion in Human Colon Cancer Caco-2 Cells Through Regulating Toll-like Receptor 4/Nuclear Factor-kappa B Pathway. Pharmacogn Mag. 2016 May;12(Suppl 2):S237-44. doi: 10.4103/0973-1296.182154. Epub 2016 May 11.
• [186] Troglitazone but not conjugated linoleic acid reduces gene expression and activity of matrix-metalloproteinases-2 and -9 in PMA-differentiated THP-1 macrophages. J Nutr Biochem. 2008 Sep;19(9):594-603. doi: 10.1016/j.jnutbio.2007.08.003. Epub 2007 Dec 21.
• [187] Multifaceted suppression of aggressive behavior of thyroid carcinoma by all-trans retinoic acid induced re-differentiation. Mol Cell Endocrinol. 2012 Jan 2;348(1):260-9. doi: 10.1016/j.mce.2011.09.002. Epub 2011 Sep 6.
• [188] Arsenic trioxide (As2O3) inhibits invasion of HT1080 human fibrosarcoma cells: role of nuclear factor-kappaB and reactive oxygen species. J Cell Biochem. 2005 Aug 1;95(5):955-69. doi: 10.1002/jcb.20452.
• [189] Aspirin inhibits MMP-2 and MMP-9 expressions and activities through upregulation of PPARalpha/gamma and TIMP gene expressions in ox-LDL-stimulated macrophages derived from human monocytes. Pharmacology. 2009;83(1):18-25. doi: 10.1159/000166183. Epub 2008 Oct 30.
• [190] Repetitive nonlethal oxidant injury to retinal pigment epithelium decreased extracellular matrix turnover in vitro and induced sub-RPE deposits in vivo. Invest Ophthalmol Vis Sci. 2006 Sep;47(9):4098-112. doi: 10.1167/iovs.05-1230.
• [191] Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium. Mol Hum Reprod. 2007 Sep;13(9):641-54.
• [192] Arsenic alters transcriptional responses to Pseudomonas aeruginosa infection and decreases antimicrobial defense of human airway epithelial cells. Toxicol Appl Pharmacol. 2017 Sep 15;331:154-163.
• [193] ROS-dependent DNA damage contributes to crizotinib-induced hepatotoxicity via the apoptotic pathway. Toxicol Appl Pharmacol. 2019 Nov 15;383:114768. doi: 10.1016/j.taap.2019.114768. Epub 2019 Oct 19.
• [194] Antitumor action of the MET tyrosine kinase inhibitor crizotinib (PF-02341066) in gastric cancer positive for MET amplification. Mol Cancer Ther. 2012 Jul;11(7):1557-64. doi: 10.1158/1535-7163.MCT-11-0934. Epub 2012 Jun 22.
• [195] All-trans retinoic acid inhibits the cell proliferation but enhances the cell invasion through up-regulation of c-met in pancreatic cancer cells. Cancer Lett. 2005 Jun 28;224(2):303-10. doi: 10.1016/j.canlet.2004.10.016. Epub 2004 Dec 8.
• [196] Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
• [197] Beta-carotene and apocarotenals promote retinoid signaling in BEAS-2B human bronchioepithelial cells. Arch Biochem Biophys. 2006 Nov 1;455(1):48-60.
• [198] Proteomics-based identification of differentially abundant proteins from human keratinocytes exposed to arsenic trioxide. J Proteomics Bioinform. 2014 Jul;7(7):166-178.
• [199] Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
• [200] Estrogen expands breast cancer stem-like cells through paracrine FGF/Tbx3 signaling. Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21737-42. doi: 10.1073/pnas.1007863107. Epub 2010 Nov 22.
• [201] Patterns of some extracellular matrix gene expression are similar in cells from cleft lip-palate patients and in human palatal fibroblasts exposed to diazepam in culture. Toxicology. 2009 Mar 4;257(1-2):10-6. doi: 10.1016/j.tox.2008.12.002. Epub 2008 Dec 9.
• [202] Imiquimod: a potential weapon against Dupuytren contracture. Med Hypotheses. 2006;66(5):991-2. doi: 10.1016/j.mehy.2005.09.052. Epub 2005 Dec 20.
• [203] Osmotic Induction of Angiogenic Growth Factor Expression in Human Retinal Pigment Epithelial Cells. PLoS One. 2016 Jan 22;11(1):e0147312. doi: 10.1371/journal.pone.0147312. eCollection 2016.
• [204] The role of simvastatin in the osteogenesis of injectable tissue-engineered bone based on human adipose-derived stromal cells and platelet-rich plasma. Biomaterials. 2010 Jul;31(20):5325-35. doi: 10.1016/j.biomaterials.2010.03.037. Epub 2010 Apr 9.
• [205] Proliferation of cultured human gingival fibroblasts caused by isradipine, a dihydropyridine-derivative calcium antagonist. Eur J Med Res. 2004 Jun 30;9(6):313-5.
• [206] The effect of valdecoxib on the production of growth factors evoked by hypoxia and bacterial lipopolysaccharide in HMEC-1 cells. Adv Clin Exp Med. 2013 Nov-Dec;22(6):795-800.
• [207] Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 Feb 26;10(1):3450. doi: 10.1038/s41598-020-59827-1.
• [208] Gene expression profile of human lymphoid CEM cells sensitive and resistant to glucocorticoid-evoked apoptosis. Genomics. 2003 Jun;81(6):543-55.
• [209] Identification of biomarkers and outcomes of endocrine disruption in human ovarian cortex using In Vitro Models. Toxicology. 2023 Feb;485:153425. doi: 10.1016/j.tox.2023.153425. Epub 2023 Jan 5.
• [210] Monomeric and oligomeric flavanols maintain the endogenous glucocorticoid response in human macrophages in pro-oxidant conditions in vitro. Chem Biol Interact. 2018 Aug 1;291:237-244.
• [211] Nicotine up-regulates IL-8 expression in human gingival epithelial cells following stimulation with IL-1 or P. gingivalis lipopolysaccharide via nicotinic acetylcholine receptor signalling. Arch Oral Biol. 2012 May;57(5):483-90. doi: 10.1016/j.archoralbio.2011.10.007. Epub 2011 Nov 25.
• [212] Ca(2+) Signaling and IL-8 Secretion in Human Testicular Peritubular Cells Involve the Cation Channel TRPV2. Int J Mol Sci. 2018 Sep 19;19(9):2829. doi: 10.3390/ijms19092829.
• [213] Nitrogen mustard prevents transport of Fra-1 into the nucleus to promote c-Fos- and FosB-dependent IL-8 induction in injured mouse epidermis. Toxicol Lett. 2020 Feb 1;319:256-263. doi: 10.1016/j.toxlet.2019.10.006. Epub 2019 Oct 19.
• [214] Nitric oxide synthase inhibitors attenuate ozone-induced airway inflammation in guinea pigs. Possible role of interleukin-8. Am J Respir Crit Care Med. 2000 Jan;161(1):249-56. doi: 10.1164/ajrccm.161.1.9804096.
• [215] Transcriptional profiling of lactic acid treated reconstructed human epidermis reveals pathways underlying stinging and itch. Toxicol In Vitro. 2019 Jun;57:164-173.
• [216] Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell. 2009 Aug 21;138(4):645-659. doi: 10.1016/j.cell.2009.06.034. Epub 2009 Aug 13.
• [217] Human oligodendrocytes derived from embryonic stem cells: Effect of noggin on phenotypic differentiation in vitro and on myelination in vivo. Mol Cell Neurosci. 2007 Mar;34(3):310-23. doi: 10.1016/j.mcn.2006.11.008. Epub 2006 Dec 28.
• [218] Genomic and proteomic profiling of responses to toxic metals in human lung cells. Environ Health Perspect. 2003 May;111(6):825-35.
• [219] Nitric oxide causes anoikis through attenuation of E-cadherin and activation of caspase-3 in human gastric carcinoma AZ-521 cells infected with Mycoplasma hyorhinis. J Vet Med Sci. 2010 Jul;72(7):869-74.
• [220] Induced differentiation in HT29, a human colon adenocarcinoma cell line. J Cell Sci. 1999 Aug;112 ( Pt 16):2657-66. doi: 10.1242/jcs.112.16.2657.
• [221] Antitumoral activity of liraglutide, a new DNMT inhibitor in breast cancer cells in vitro and in vivo. Chem Biol Interact. 2021 Nov 1;349:109641. doi: 10.1016/j.cbi.2021.109641. Epub 2021 Sep 14.
• [222] Troglitazone increases expression of E-cadherin and claudin 4 in human pancreatic cancer cells. Biochem Biophys Res Commun. 2009 Mar 13;380(3):614-9. doi: 10.1016/j.bbrc.2009.01.134. Epub 2009 Jan 27.
• [223] Regulation of epithelial cell morphology and functions approaching to more in vivo-like by modifying polyethylene glycol on polysulfone membranes. PLoS One. 2012;7(4):e36110.
• [224] Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
• [225] Cultured human peripheral blood mononuclear cells alter their gene expression when challenged with endocrine-disrupting chemicals. Toxicology. 2013 Jan 7;303:17-24.
• [226] DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia. Blood. 2016 Aug 18;128(7):971-81. doi: 10.1182/blood-2015-11-684225. Epub 2016 Jun 22.
• [227] Analysis of estrogen agonism and antagonism of tamoxifen, raloxifene, and ICI182780 in endometrial cancer cells: a putative role for the epidermal growth factor receptor ligand amphiregulin. J Soc Gynecol Investig. 2005 Oct;12(7):e55-67.
• [228] Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
• [229] Ligand-dependent activation of the epidermal growth factor receptor by secondary bile acids in polarizing colon cancer cells. Surgery. 2005 Sep;138(3):415-21. doi: 10.1016/j.surg.2005.06.030.
• [230] Moving toward integrating gene expression profiling into high-throughput testing: a gene expression biomarker accurately predicts estrogen receptor alpha modulation in a microarray compendium. Toxicol Sci. 2016 May;151(1):88-103.
• [231] Effects of chlorpromazine with and without UV irradiation on gene expression of HepG2 cells. Mutat Res. 2005 Aug 4;575(1-2):47-60. doi: 10.1016/j.mrfmmm.2005.03.002. Epub 2005 Apr 26.
• [232] Amphiregulin is a vitamin D3 target gene in squamous cell and breast carcinoma. Biochem Biophys Res Commun. 2001 Mar 9;281(4):1051-6. doi: 10.1006/bbrc.2001.4466.
• [233] Dysregulation of integrin-linked kinase (ILK) signaling in colonic polyposis. Oncogene. 2001 Sep 27;20(43):6250-7. doi: 10.1038/sj.onc.1204791.
• [234] Quercetin, a potent inhibitor against beta-catenin/Tcf signaling in SW480 colon cancer cells. Biochem Biophys Res Commun. 2005 Mar 4;328(1):227-34. doi: 10.1016/j.bbrc.2004.12.151.
• [235] Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
• [236] Nuclear and Mitochondrial DNA Methylation Patterns Induced by Valproic Acid in Human Hepatocytes. Chem Res Toxicol. 2017 Oct 16;30(10):1847-1854. doi: 10.1021/acs.chemrestox.7b00171. Epub 2017 Sep 13.
• [237] Enhancement of the antiproliferative activity of gemcitabine by modulation of c-Met pathway in pancreatic cancer. Curr Pharm Des. 2013;19(5):940-50.
• [238] JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Oncogene. 2008 Aug 28;27(37):5033-44.
• [239] Methylation status of the Ep-CAM promoter region in human breast cancer cell lines and breast cancer tissue. Cancer Lett. 2007 Feb 8;246(1-2):253-61. doi: 10.1016/j.canlet.2006.03.002. Epub 2006 Apr 18.
• [240] Novel functional view of the crocidolite asbestos-treated A549 human lung epithelial transcriptome reveals an intricate network of pathways with opposing functions. BMC Genomics. 2008 Aug 7;9:376.
• [241] 1,25-dihydroxyvitamin D3 stimulates activin A production to fine-tune osteoblast-induced mineralization. J Cell Physiol. 2013 Nov;228(11):2167-74. doi: 10.1002/jcp.24388.
• [242] Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
• [243] Modulation of fibroblast growth factor receptor expression and signalling during retinoic acid-induced differentiation of Tera-2 teratocarcinoma cells. Biochem Biophys Res Commun. 1993 Feb 26;191(1):149-56. doi: 10.1006/bbrc.1993.1196.
• [244] Thalidomide and Its Analogs Differentially Target Fibroblast Growth Factor Receptors: Thalidomide Suppresses FGFR Gene Expression while Pomalidomide Dampens FGFR2 Activity. Chem Res Toxicol. 2019 Apr 15;32(4):589-602. doi: 10.1021/acs.chemrestox.8b00286. Epub 2019 Mar 15.
• [245] Curcumin reduces the expression of survivin, leading to enhancement of arsenic trioxide-induced apoptosis in myelodysplastic syndrome and leukemia stem-like cells. Oncol Rep. 2016 Sep;36(3):1233-42. doi: 10.3892/or.2016.4944. Epub 2016 Jul 15.
• [246] Effects of Imatinib Mesylate (Gleevec) on human islet NF-kappaB activation and chemokine production in vitro. PLoS One. 2011;6(9):e24831. doi: 10.1371/journal.pone.0024831. Epub 2011 Sep 14.
• [247] Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells. J Cell Biochem. 2006 Aug 1;98(5):1163-84.
• [248] Polyunsaturated fatty acids synergize with lipid droplet binding thalidomide analogs to induce oxidative stress in cancer cells. Lipids Health Dis. 2010 Jun 2;9:56. doi: 10.1186/1476-511X-9-56.
• [249] Febuxostat Increases Ventricular Arrhythmogenesis Through Calcium Handling Dysregulation in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Toxicol Sci. 2022 Sep 24;189(2):216-224. doi: 10.1093/toxsci/kfac073.
• [250] Synergistic effects of arsenic trioxide combined with ascorbic acid in human osteosarcoma MG-63 cells: a systems biology analysis. Eur Rev Med Pharmacol Sci. 2014;18(24):3877-88.
• [251] Expression profiling in squamous carcinoma cells reveals pleiotropic effects of vitamin D3 analog EB1089 signaling on cell proliferation, differentiation, and immune system regulation. Mol Endocrinol. 2002 Jun;16(6):1243-56.
• [252] Neurotoxicity and underlying cellular changes of 21 mitochondrial respiratory chain inhibitors. Arch Toxicol. 2021 Feb;95(2):591-615. doi: 10.1007/s00204-020-02970-5. Epub 2021 Jan 29.
• [253] In-vivo effects of simvastatin and rosuvastatin on global gene expression in peripheral blood leucocytes in a human inflammation model. Pharmacogenet Genomics. 2008 Feb;18(2):109-20.
• [254] Arsenic promotes the COX2/PGE2-SOX2 axis to increase the malignant stemness properties of urothelial cells. Int J Cancer. 2018 Jul 1;143(1):113-126.
• [255] Arsenic and fluoride induce apoptosis, inflammation and oxidative stress in cultured human umbilical vein endothelial cells. Chemosphere. 2017 Jan;167:454-461. doi: 10.1016/j.chemosphere.2016.10.025. Epub 2016 Oct 14.
• [256] Synergistic antiproliferative effect of arsenic trioxide combined with bortezomib in HL60 cell line and primary blasts from patients affected by myeloproliferative disorders. Cancer Genet Cytogenet. 2010 Jun;199(2):110-20. doi: 10.1016/j.cancergencyto.2010.02.010.
• [257] Treatment with anticancer agents induces dysregulation of specific Wnt signaling pathways in human ovarian luteinized granulosa cells in vitro. Toxicol Sci. 2013 Nov;136(1):183-92. doi: 10.1093/toxsci/kft175. Epub 2013 Aug 16.
• [258] Progesterone increases csk homologous kinase in HMC-1560 human mast cells and reduces cell proliferation. J Cell Biochem. 2007 Dec 1;102(5):1271-80. doi: 10.1002/jcb.21357.
• [259] Cannabidiol upregulates melanogenesis through CB1 dependent pathway by activating p38 MAPK and p42/44 MAPK. Chem Biol Interact. 2017 Aug 1;273:107-114. doi: 10.1016/j.cbi.2017.06.005. Epub 2017 Jun 7.
• [260] Sertraline, an antidepressant, induces apoptosis in hepatic cells through the mitogen-activated protein kinase pathway. Toxicol Sci. 2014 Feb;137(2):404-15. doi: 10.1093/toxsci/kft254. Epub 2013 Nov 5.
• [261] Growth stimulation of human pulmonary adenocarcinoma cells and small airway epithelial cells by beta-carotene via activation of cAMP, PKA, CREB and ERK1/2. Int J Cancer. 2006 Mar 15;118(6):1370-80. doi: 10.1002/ijc.21537.
• [262] Estrogen and pure antiestrogen fulvestrant (ICI 182 780) augment cell-matrigel adhesion of MCF-7 breast cancer cells through a novel G protein coupled estrogen receptor (GPR30)-to-calpain signaling axis. Toxicol Appl Pharmacol. 2014 Mar 1;275(2):176-81. doi: 10.1016/j.taap.2014.01.005. Epub 2014 Jan 17.
• [263] Inhibition of activator protein 1 by barbiturates is mediated by differential effects on mitogen-activated protein kinases and the small G proteins ras and rac-1. J Pharmacol Exp Ther. 2004 Dec;311(3):1232-40. doi: 10.1124/jpet.104.071332. Epub 2004 Jul 19.
• [264] Growth of hormone-dependent MCF-7 breast cancer cells is promoted by constitutive caveolin-1 whose expression is lost in an EGF-R-mediated manner during development of tamoxifen resistance. Breast Cancer Res Treat. 2010 Feb;119(3):575-91. doi: 10.1007/s10549-009-0355-8. Epub 2009 Mar 15.
• [265] Effect of histamine H1 receptor antagonists on TARC/CCL17 and MDC/CCL22 production from CD14+ cells induced by antigenic stimulation in vitro. Int Arch Allergy Immunol. 2011;155(1):38-51. doi: 10.1159/000318720. Epub 2010 Nov 25.
• [266] SIRT3 Mediates the Antioxidant Effect of Hydrogen Sulfide in Endothelial Cells. Antioxid Redox Signal. 2016 Feb 20;24(6):329-43. doi: 10.1089/ars.2015.6331. Epub 2015 Nov 10.
• [267] Downregulation of mitogen-activated protein kinases (MAPKs) in chronic ethanol-induced fatty liver. Toxicol Mech Methods. 2020 Jul;30(6):407-416. doi: 10.1080/15376516.2020.1747126. Epub 2020 Apr 1.
• [268] A unique mechanism of beta-blocker action: carvedilol stimulates beta-arrestin signaling. Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16657-62. doi: 10.1073/pnas.0707936104. Epub 2007 Oct 9.
• [269] The stent-eluting drugs sirolimus and paclitaxel suppress healing of the endothelium by induction of autophagy. Am J Pathol. 2009 Nov;175(5):2226-34.
• [270] Modulation of apoptosis in HaCaT keratinocytes via differential regulation of ERK signaling pathway by flavonoids. J Biol Chem. 2005 Sep 9;280(36):31498-507. doi: 10.1074/jbc.M505537200. Epub 2005 Jul 13.
• [271] The in vitro effects of quinupristin/dalfopristin, erythromycin and levofloxacin at low concentrations on the expression of different cell adhesion molecules on the surface of endothelial cells (Eahy926). Toxicology. 2006 Jan 20;218(1):30-8. doi: 10.1016/j.tox.2005.09.014. Epub 2005 Nov 16.
• [272] Synergistic killing effects of homoharringtonine and arsenic trioxide on acute myeloid leukemia stem cells and the underlying mechanisms. J Exp Clin Cancer Res. 2019 Jul 15;38(1):308. doi: 10.1186/s13046-019-1295-8.
• [273] Suppression of cancer relapse and metastasis by inhibiting cancer stemness. Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1839-44. doi: 10.1073/pnas.1424171112. Epub 2015 Jan 20.
• [274] Expression and mitogenic effect of fibroblast growth factor-9 in human endometriotic implant is regulated by aberrant production of estrogen. J Clin Endocrinol Metab. 2003 Nov;88(11):5547-54. doi: 10.1210/jc.2003-030597.
• [275] Role of phenytoin in wound healing: microarray analysis of early transcriptional responses in human dermal fibroblasts. Biochem Biophys Res Commun. 2004 Feb 13;314(3):661-6. doi: 10.1016/j.bbrc.2003.12.146.
• [276] Clinical determinants of response to irinotecan-based therapy derived from cell line models. Clin Cancer Res. 2008 Oct 15;14(20):6647-55.
• [277] Fibroblast growth factor-9 is an endometrial stromal growth factor. Endocrinology. 2002 Jul;143(7):2715-21. doi: 10.1210/endo.143.7.8900.
• [278] Inhibition of autophagic flux differently modulates cannabidiol-induced death in 2D and 3D glioblastoma cell cultures. Sci Rep. 2020 Feb 14;10(1):2687. doi: 10.1038/s41598-020-59468-4.
• [279] Sulindac suppresses beta-catenin expression in human cancer cells. Eur J Pharmacol. 2008 Mar 31;583(1):26-31. doi: 10.1016/j.ejphar.2007.12.034. Epub 2008 Feb 5.
• [280] Multifaceted preventive effects of single agent quercetin on a human prostate adenocarcinoma cell line (PC-3): implications for nutritional transcriptomics and multi-target therapy. Med Oncol. 2011 Dec;28(4):1395-404. doi: 10.1007/s12032-010-9603-3. Epub 2010 Jul 2.
• [281] Arsenic trioxide and 2-methoxyestradiol reduce beta-catenin accumulation after proteasome inhibition and enhance the sensitivity of myeloma cells to Bortezomib. Leuk Res. 2008 Nov;32(11):1674-83. doi: 10.1016/j.leukres.2008.03.039. Epub 2008 May 15.
• [282] Effect of aspirin on the Wnt/beta-catenin pathway is mediated via protein phosphatase 2A. Oncogene. 2006 Oct 19;25(49):6447-56. doi: 10.1038/sj.onc.1209658. Epub 2006 Jul 31.
• [283] Benzene metabolite hydroquinone induces apoptosis of bone marrow mononuclear cells through inhibition of -catenin signaling. Toxicol In Vitro. 2018 Feb;46:361-369. doi: 10.1016/j.tiv.2017.08.018. Epub 2017 Sep 5.
• [284] Anti-androgen 2-hydroxyflutamide modulates cadherin, catenin and androgen receptor phosphorylation in androgen-sensitive LNCaP and androgen-independent PC3 prostate cancer cell lines acting via PI3K/Akt and MAPK/ERK1/2 pathways. Toxicol In Vitro. 2017 Apr;40:324-335. doi: 10.1016/j.tiv.2017.01.019. Epub 2017 Feb 2.
• [285] Anthelmintic Niclosamide Disrupts the Interplay of p65 and FOXM1/-catenin and Eradicates Leukemia Stem Cells in Chronic Myelogenous Leukemia. Clin Cancer Res. 2017 Feb 1;23(3):789-803. doi: 10.1158/1078-0432.CCR-16-0226. Epub 2016 Aug 4.
• [286] Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur J Nutr. 2005 Mar;44(3):143-56. doi: 10.1007/s00394-004-0503-1. Epub 2004 Apr 30.
• [287] Primary Human Hepatocyte Spheroids as Tools to Study the Hepatotoxic Potential of Non-Pharmaceutical Chemicals. Int J Mol Sci. 2021 Oct 12;22(20):11005. doi: 10.3390/ijms222011005.
• [288] [Effect of arsenic trioxide on vascular endothelial growth factor-C and its receptor (VEGFR-3) in nude mice with gastric cancer]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2008 Dec;16(6):1303-7.
• [289] Exposure to Insecticides Modifies Gene Expression and DNA Methylation in Hematopoietic Tissues In Vitro. Int J Mol Sci. 2023 Mar 26;24(7):6259. doi: 10.3390/ijms24076259.
• [290] Antitumor activity and biomarker analysis of sunitinib in patients with bevacizumab-refractory metastatic renal cell carcinoma. J Clin Oncol. 2008 Aug 1;26(22):3743-8. doi: 10.1200/JCO.2007.15.5416.
• [291] Discovery of 5-(arenethynyl) hetero-monocyclic derivatives as potent inhibitors of BCR-ABL including the T315I gatekeeper mutant. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3743-8.
• [292] Histone deacetylase inhibitor scriptaid induces cell cycle arrest and epigenetic change in colon cancer cells. Int J Oncol. 2008 Oct;33(4):767-76.
• [293] Isobaric tags for relative and absolute quantitation-based proteomics analysis of the effect of ginger oil on bisphenol A-induced breast cancer cell proliferation. Oncol Lett. 2021 Feb;21(2):101. doi: 10.3892/ol.2020.12362. Epub 2020 Dec 8.
• [294] Capsaicin promotes a more aggressive gene expression phenotype and invasiveness in null-TRPV1 urothelial cancer cells. Carcinogenesis. 2011 May;32(5):686-94. doi: 10.1093/carcin/bgr025. Epub 2011 Feb 10.
• [295] Immunomodulatory effect of selective serotonin reuptake inhibitors (SSRIs) on human T lymphocyte function and gene expression. Eur Neuropsychopharmacol. 2007 Dec;17(12):774-80.
• [296] Diesel exhaust particulate-induced activation of Stat3 requires activities of EGFR and Src in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2007 Feb;292(2):L422-9. doi: 10.1152/ajplung.00204.2006. Epub 2006 Oct 6.
• [297] Physapubescin B enhances the sensitivity of gastric cancer cells to trametinib by inhibiting the STAT3 signaling pathway. Toxicol Appl Pharmacol. 2020 Dec 1;408:115273. doi: 10.1016/j.taap.2020.115273. Epub 2020 Oct 6.
• [298] Sulindac induces apoptosis and inhibits tumor growth in vivo in head and neck squamous cell carcinoma. Neoplasia. 2007 Mar;9(3):192-9. doi: 10.1593/neo.06781.
• [299] Simvastatin acts as an inhibitor of interferon gamma-induced cycloxygenase-2 expression in human THP-1 cells, but not in murine RAW264.7 cells. Biocell. 2009 Aug;33(2):107-14.
• [300] Therapeutic potential of cladribine in combination with STAT3 inhibitor against multiple myeloma. BMC Cancer. 2011 Jun 16;11:255. doi: 10.1186/1471-2407-11-255.
• [301] Quercetin exerts anti-melanoma activities and inhibits STAT3 signaling. Biochem Pharmacol. 2014 Feb 1;87(3):424-34. doi: 10.1016/j.bcp.2013.11.008. Epub 2013 Nov 23.
• [302] Altered cytokine profiles of human retinal pigment epithelium: oxidant injury and replicative senescence. Mol Vis. 2013;19:718-28. Epub 2013 Mar 21.
• [303] Glucocorticoids inhibit cell death in ovarian cancer and up-regulate caspase inhibitor cIAP2. Clin Cancer Res. 2005 Sep 1;11(17):6325-32. doi: 10.1158/1078-0432.CCR-05-0182.
• [304] Oxidative stress triggers STAT3 tyrosine phosphorylation and nuclear translocation in human lymphocytes. J Biol Chem. 1999 Jun 18;274(25):17580-6. doi: 10.1074/jbc.274.25.17580.
• [305] Response rate of fibrosarcoma cells to cytotoxic drugs on the expression level correlates to the therapeutic response rate of fibrosarcomas and is mediated by regulation of apoptotic pathways. BMC Cancer. 2005 Jul 7;5:74. doi: 10.1186/1471-2407-5-74.
• [306] Molecular mechanisms underlying the inhibition of IFN--induced, STAT1-mediated gene transcription in human macrophages by simvastatin and agonists of PPARs and LXRs. J Cell Biochem. 2011 Feb;112(2):675-83. doi: 10.1002/jcb.22976.
• [307] Quercetin and Its Fermented Extract as a Potential Inhibitor of Bisphenol A-Exposed HT-29 Colon Cancer Cells' Viability. Int J Mol Sci. 2023 Mar 15;24(6):5604. doi: 10.3390/ijms24065604.
• [308] Benzodithiophenes potentiate differentiation of acute promyelocytic leukemia cells by lowering the threshold for ligand-mediated corepressor/coactivator exchange with retinoic acid receptor alpha and enhancing changes in all-trans-retinoic acid-regulated gene expression. Cancer Res. 2005 Sep 1;65(17):7856-65. doi: 10.1158/0008-5472.CAN-05-1056.
• [309] The aryl hydrocarbon receptor activates the retinoic acid receptoralpha through SMRT antagonism. Biochimie. 2006 Mar-Apr;88(3-4):387-97. doi: 10.1016/j.biochi.2005.11.007. Epub 2005 Dec 7.
• [310] Inter-laboratory comparison of human renal proximal tubule (HK-2) transcriptome alterations due to Cyclosporine A exposure and medium exhaustion. Toxicol In Vitro. 2009 Apr;23(3):486-99.
• [311] Identification of novel low-dose bisphenol a targets in human foreskin fibroblast cells derived from hypospadias patients. PLoS One. 2012;7(5):e36711. doi: 10.1371/journal.pone.0036711. Epub 2012 May 4.
• [312] The retinoid anticancer signal: mechanisms of target gene regulation. Br J Cancer. 2005 Aug 8;93(3):310-8. doi: 10.1038/sj.bjc.6602700.
• [313] Transcriptional and epigenetic regulation of the integrin collagen receptor locus ITGA1-PELO-ITGA2. Biochim Biophys Acta. 2007 Sep-Oct;1769(9-10):546-58. doi: 10.1016/j.bbaexp.2007.06.004. Epub 2007 Jul 6.
• [314] Proteomic analysis of hepatic effects of phenobarbital in mice with humanized liver. Arch Toxicol. 2022 Oct;96(10):2739-2754. doi: 10.1007/s00204-022-03338-7. Epub 2022 Jul 26.
• [315] Differential gene expression in human hepatocyte cell lines exposed to the antiretroviral agent zidovudine. Arch Toxicol. 2014 Mar;88(3):609-23. doi: 10.1007/s00204-013-1169-3. Epub 2013 Nov 30.
• [316] Bromodomain-containing protein 4 (BRD4) regulates RNA polymerase II serine 2 phosphorylation in human CD4+ T cells. J Biol Chem. 2012 Dec 14;287(51):43137-55.
• [317] Identification and characterization of 3-iodothyronamine intracellular transport. Endocrinology. 2009 Apr;150(4):1991-9.
• [318] Gene expression profile induced by arsenic trioxide in chronic lymphocytic leukemia cells reveals a central role for heme oxygenase-1 in apoptosis and regulation of matrix metalloproteinase-9. Oncotarget. 2016 Dec 13;7(50):83359-83377.
• [319] Research resource: STR DNA profile and gene expression comparisons of human BG-1 cells and a BG-1/MCF-7 clonal variant. Mol Endocrinol. 2014 Dec;28(12):2072-81.
• [320] Cytosine arabinoside induces ectoderm and inhibits mesoderm expression in human embryonic stem cells during multilineage differentiation. Br J Pharmacol. 2011 Apr;162(8):1743-56.
• [321] Targeting MYCN in neuroblastoma by BET bromodomain inhibition. Cancer Discov. 2013 Mar;3(3):308-23.
• [322] Omeprazole inhibits pancreatic cancer cell invasion through a nongenomic aryl hydrocarbon receptor pathway. Chem Res Toxicol. 2015 May 18;28(5):907-18.
• [323] Cannabinoids synergize with carfilzomib, reducing multiple myeloma cells viability and migration. Oncotarget. 2016 Nov 22;7(47):77543-77557. doi: 10.18632/oncotarget.12721.
• [324] Arsenic trioxide inhibits CXCR4-mediated metastasis by interfering miR-520h/PP2A/NF-B signaling in cervical cancer. Ann Surg Oncol. 2014 Dec;21 Suppl 4:S687-95. doi: 10.1245/s10434-014-3812-5. Epub 2014 Jul 22.
• [325] Etodolac induces apoptosis and inhibits cell adhesion to bone marrow stromal cells in human myeloma cells. Leuk Res. 2006 Feb;30(2):123-35. doi: 10.1016/j.leukres.2005.06.009. Epub 2005 Jul 25.
• [326] Inhibition of cardiomyocyte differentiation of human induced pluripotent stem cells by Ribavirin: Implication for its cardiac developmental toxicity. Toxicology. 2020 Apr 15;435:152422. doi: 10.1016/j.tox.2020.152422. Epub 2020 Feb 26.
• [327] Peroxisome proliferator activated receptor gamma (PPAR-gama) ligand pioglitazone regulated gene networks in term human primary trophoblast cells. Reprod Toxicol. 2018 Oct;81:99-107.
• [328] Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity. Toxicology. 2014 Jan 6;315:8-16. doi: 10.1016/j.tox.2013.10.009. Epub 2013 Nov 6.
• [329] Comparison of the gene expression profiles of monocytic versus granulocytic lineages of HL-60 leukemia cell differentiation by DNA microarray analysis. Life Sci. 2003 Aug 15;73(13):1705-19. doi: 10.1016/s0024-3205(03)00515-0.
• [330] Gene expression profile of multiple myeloma cell line treated by arsenic trioxide. J Huazhong Univ Sci Technolog Med Sci. 2007 Dec;27(6):646-9. doi: 10.1007/s11596-007-0606-z.
• [331] Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
• [332] Mitochondrial Uncoupling Induces Epigenome Remodeling and Promotes Differentiation in Neuroblastoma. Cancer Res. 2023 Jan 18;83(2):181-194. doi: 10.1158/0008-5472.CAN-22-1029.
• [333] Modulation of FoxO signaling in human hepatoma cells by exposure to copper or zinc ions. Arch Biochem Biophys. 2006 Oct 15;454(2):107-13. doi: 10.1016/j.abb.2006.08.016. Epub 2006 Aug 30.
• [334] Decitabine up-regulates S100A2 expression and synergizes with IFN-gamma to kill uveal melanoma cells. Clin Cancer Res. 2007 Sep 1;13(17):5219-25. doi: 10.1158/1078-0432.CCR-07-0816.
• [335] Role of microRNAs in senescence and its contribution to peripheral neuropathy in the arsenic exposed population of West Bengal, India. Environ Pollut. 2018 Feb;233:596-603. doi: 10.1016/j.envpol.2017.09.063. Epub 2017 Nov 5.
• [336] MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia. Cell Biol Toxicol. 2023 Feb;39(1):201-216. doi: 10.1007/s10565-021-09639-4. Epub 2021 Sep 28.
• [337] Monitoring of deiodinase deficiency based on transcriptomic responses in SH-SY5Y cells. Arch Toxicol. 2013 Jun;87(6):1103-13. doi: 10.1007/s00204-013-1018-4. Epub 2013 Feb 10.
• [338] Id2 gene-targeted crosstalk between Wnt and retinoid signaling regulates proliferation in human keratinocytes. Oncogene. 2007 Aug 2;26(35):5038-45. doi: 10.1038/sj.onc.1210320. Epub 2007 Feb 19.
• [339] Transcriptome-based functional classifiers for direct immunotoxicity. Arch Toxicol. 2014 Mar;88(3):673-89.
• [340] -Carotene Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cell Lines via the Cav-1/AKT/NF-B Signaling Pathway. J Biochem Mol Toxicol. 2016 Mar;30(3):148-57. doi: 10.1002/jbt.21773. Epub 2016 Jan 6.
• [341] The protective effect of quercetin against oxidative stress in the human RPE in vitro. Invest Ophthalmol Vis Sci. 2008 Apr;49(4):1712-20. doi: 10.1167/iovs.07-0477.
• [342] Nitric oxide regulates lung carcinoma cell anoikis through inhibition of ubiquitin-proteasomal degradation of caveolin-1. J Biol Chem. 2009 Oct 9;284(41):28476-28484. doi: 10.1074/jbc.M109.050864. Epub 2009 Aug 25.
• [343] Ouabain impairs cell migration, and invasion and alters gene expression of human osteosarcoma U-2 OS cells. Environ Toxicol. 2017 Nov;32(11):2400-2413. doi: 10.1002/tox.22453. Epub 2017 Aug 10.
• [344] AS3MT facilitates NLRP3 inflammasome activation by m(6)A modification during arsenic-induced hepatic insulin resistance. Cell Biol Toxicol. 2023 Oct;39(5):2165-2181. doi: 10.1007/s10565-022-09703-7. Epub 2022 Feb 28.
• [345] Hydroquinone triggers pyroptosis and endoplasmic reticulum stress via AhR-regulated oxidative stress in human lymphocytes. Toxicol Lett. 2023 Mar 1;376:39-50. doi: 10.1016/j.toxlet.2023.01.005. Epub 2023 Jan 13.
• [346] Cimetidine induces interleukin-18 production through H2-agonist activity in monocytes. Mol Pharmacol. 2006 Aug;70(2):450-3. doi: 10.1124/mol.106.025890. Epub 2006 May 24.
• [347] Dihydroartemisinin induces pyroptosis by promoting the AIM2/caspase-3/DFNA5 axis in breast cancer cells. Chem Biol Interact. 2021 May 1;340:109434. doi: 10.1016/j.cbi.2021.109434. Epub 2021 Mar 6.
• [348] Association of CYP1A1 and CYP1B1 inhibition in in vitro assays with drug-induced liver injury. J Toxicol Sci. 2021;46(4):167-176. doi: 10.2131/jts.46.167.
• [349] Convergent transcriptional profiles induced by endogenous estrogen and distinct xenoestrogens in breast cancer cells. Carcinogenesis. 2006 Aug;27(8):1567-78.
• [350] In vitro aromatic bioactivation of the weak estrogen E(2)alpha and genesis of DNA adducts. Steroids. 2005 Mar;70(3):161-72. doi: 10.1016/j.steroids.2004.11.004.
• [351] Metabolism of melatonin by human cytochromes p450. Drug Metab Dispos. 2005 Apr;33(4):489-94.
• [352] Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1. Drug Metab Dispos. 2004 Aug;32(8):840-7.
• [353] Apoptosis contributes to the cytotoxicity induced by amodiaquine and its major metabolite N-desethylamodiaquine in hepatic cells. Toxicol In Vitro. 2020 Feb;62:104669. doi: 10.1016/j.tiv.2019.104669. Epub 2019 Oct 16.
• [354] Genetic variants contributing to daunorubicin-induced cytotoxicity. Cancer Res. 2008 May 1;68(9):3161-8. doi: 10.1158/0008-5472.CAN-07-6381.
• [355] Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells. Nat Commun. 2018 Aug 9;9(1):3069. doi: 10.1038/s41467-018-05402-2.
• [356] Resveratrol induces apoptosis and alters gene expression in human fibrosarcoma cells. Anticancer Res. 2015 Feb;35(2):767-74.
• [357] Epigenetic changes in individuals with arsenicosis. Chem Res Toxicol. 2011 Feb 18;24(2):165-7. doi: 10.1021/tx1004419. Epub 2011 Feb 4.
• [358] The MT1G Gene in LUHMES Neurons Is a Sensitive Biomarker of Neurotoxicity. Neurotox Res. 2020 Dec;38(4):967-978. doi: 10.1007/s12640-020-00272-3. Epub 2020 Sep 1.
• [359] Effect of prenatal arsenic exposure on DNA methylation and leukocyte subpopulations in cord blood. Epigenetics. 2014 May;9(5):774-82. doi: 10.4161/epi.28153. Epub 2014 Feb 13.
• [360] Gene expression profile and cytotoxicity of human bronchial epithelial cells exposed to crotonaldehyde. Toxicol Lett. 2010 Aug 16;197(2):113-22.
• [361] Persistent and non-persistent changes in gene expression result from long-term estrogen exposure of MCF-7 breast cancer cells. J Steroid Biochem Mol Biol. 2011 Feb;123(3-5):140-50.
• [362] The NRF2-mediated oxidative stress response pathway is associated with tumor cell resistance to arsenic trioxide across the NCI-60 panel. BMC Med Genomics. 2010 Aug 13;3:37. doi: 10.1186/1755-8794-3-37.
• [363] Novel ATP-competitive Akt inhibitor afuresertib suppresses the proliferation of malignant pleural mesothelioma cells. Cancer Med. 2017 Nov;6(11):2646-2659. doi: 10.1002/cam4.1179. Epub 2017 Sep 27.
• [364] Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
• [365] Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells. Eur J Pharmacol. 2014 Jun 5;732:60-7.
• [366] Bisphenol A induces DSB-ATM-p53 signaling leading to cell cycle arrest, senescence, autophagy, stress response, and estrogen release in human fetal lung fibroblasts. Arch Toxicol. 2018 Apr;92(4):1453-1469.
• [367] Profiling transcriptomes of human SH-SY5Y neuroblastoma cells exposed to maleic acid. PeerJ. 2017 Apr 5;5:e3175.
• [368] Bone marrow osteoblast damage by chemotherapeutic agents. PLoS One. 2012;7(2):e30758. doi: 10.1371/journal.pone.0030758. Epub 2012 Feb 17.
• [369] Vitamin K promotes mineralization, osteoblast-to-osteocyte transition, and an anticatabolic phenotype by {gamma}-carboxylation-dependent and -independent mechanisms. Am J Physiol Cell Physiol. 2009 Dec;297(6):C1358-67. doi: 10.1152/ajpcell.00216.2009. Epub 2009 Aug 12.
• [370] The effect of DNA methylation inhibitor 5-Aza-2'-deoxycytidine on human endometrial stromal cells. Hum Reprod. 2010 Nov;25(11):2859-69.
• [371] Arsenic trioxide increases expression of secreted frizzled-related protein 1 gene and inhibits the WNT/-catenin signaling pathway in Jurkat cells. Exp Ther Med. 2017 May;13(5):2050-2055. doi: 10.3892/etm.2017.4184. Epub 2017 Mar 6.
• [372] Chronic ethanol exposure increases goosecoid (GSC) expression in human embryonic carcinoma cell differentiation. J Appl Toxicol. 2014 Jan;34(1):66-75.
• [373] Folic acid modulates cancer-associated micro RNAs and inflammatory mediators in neoplastic and non-neoplastic colonic cells in a different way. Mol Nutr Food Res. 2017 Dec;61(12). doi: 10.1002/mnfr.201700260. Epub 2017 Nov 9.
• [374] Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297. doi: 10.1016/j.fct.2020.111297. Epub 2020 Mar 28.
• [375] Effects of lithium and valproic acid on gene expression and phenotypic markers in an NT2 neurosphere model of neural development. PLoS One. 2013;8(3):e58822.
• [376] Malathion induced cancer-linked gene expression in human lymphocytes. Environ Res. 2020 Mar;182:109131. doi: 10.1016/j.envres.2020.109131. Epub 2020 Jan 10.
• [377] Anti-oncogenic and pro-differentiation effects of clorgyline, a monoamine oxidase A inhibitor, on high grade prostate cancer cells. BMC Med Genomics. 2009 Aug 20;2:55. doi: 10.1186/1755-8794-2-55.
• [378] Nitric oxide suppresses tumor cell migration through N-Myc downstream-regulated gene-1 (NDRG1) expression: role of chelatable iron. J Biol Chem. 2011 Dec 2;286(48):41413-41424. doi: 10.1074/jbc.M111.287052. Epub 2011 Oct 5.
• [379] Differential gene expression of sulindac-treated human breast epithelial cells. Int J Oncol. 2005 Dec;27(6):1727-36.
• [380] Involvement of the Endocrine-Disrupting Chemical Bisphenol A (BPA) in Human Placentation. J Clin Med. 2020 Feb 3;9(2):405. doi: 10.3390/jcm9020405.
• [381] Transcriptome profile analysis of saturated aliphatic aldehydes reveals carbon number-specific molecules involved in pulmonary toxicity. Chem Res Toxicol. 2014 Aug 18;27(8):1362-70.
• [382] Transcriptome and DNA methylation changes modulated by sulforaphane induce cell cycle arrest, apoptosis, DNA damage, and suppression of proliferation in human liver cancer cells. Food Chem Toxicol. 2020 Feb;136:111047. doi: 10.1016/j.fct.2019.111047. Epub 2019 Dec 12.
• [383] Isoproterenol effects evaluated in heart slices of human and rat in comparison to rat heart in vivo. Toxicol Appl Pharmacol. 2014 Jan 15;274(2):302-12.
• [384] Long-term estrogen exposure promotes carcinogen bioactivation, induces persistent changes in gene expression, and enhances the tumorigenicity of MCF-7 human breast cancer cells. Toxicol Appl Pharmacol. 2009 Nov 1;240(3):355-66.
• [385] Effects of nicotine and lipopolysaccharide on the expression of matrix metalloproteinases, plasminogen activators, and their inhibitors in human osteoblasts. Arch Oral Biol. 2009 Feb;54(2):146-55.
• [386] Comparative effects of raloxifene, tamoxifen and estradiol on human osteoblasts in vitro: estrogen receptor dependent or independent pathways of raloxifene. J Steroid Biochem Mol Biol. 2009 Feb;113(3-5):281-9.
• [387] Mutant p53 reactivation by PRIMA-1MET induces multiple signaling pathways converging on apoptosis. Oncogene. 2010 Mar 4;29(9):1329-38. doi: 10.1038/onc.2009.425. Epub 2009 Nov 30.
• [388] Effects of progesterone treatment on expression of genes involved in uterine quiescence. Reprod Sci. 2011 Aug;18(8):781-97.
• [389] Glucosamine decreases expression of anabolic and catabolic genes in human osteoarthritic cartilage explants. Osteoarthritis Cartilage. 2006 Mar;14(3):250-7. doi: 10.1016/j.joca.2005.10.001. Epub 2005 Nov 18.
• [390] Effects of aspirin on metastasis-associated gene expression detected by cDNA microarray. Acta Pharmacol Sin. 2004 Oct;25(10):1327-33.
• [391] Improved apoptotic cell death in drug-resistant non-small-cell lung cancer cells by tumor necrosis factor-related apoptosis-inducing ligand-based treatment. J Pharmacol Exp Ther. 2014 Mar;348(3):360-71. doi: 10.1124/jpet.113.210054. Epub 2013 Dec 17.
• [392] Ethanol directly induced HMGB1 release through NOX2/NLRP1 inflammasome in neuronal cells. Toxicology. 2015 Aug 6;334:104-10. doi: 10.1016/j.tox.2015.06.006. Epub 2015 Jun 12.
• [393] Cell death mechanisms of the anti-cancer drug etoposide on human cardiomyocytes isolated from pluripotent stem cells. Arch Toxicol. 2018 Apr;92(4):1507-1524.
• [394] Gingival Stromal Cells as an In Vitro Model: Cannabidiol Modulates Genes Linked With Amyotrophic Lateral Sclerosis. J Cell Biochem. 2017 Apr;118(4):819-828. doi: 10.1002/jcb.25757. Epub 2016 Nov 28.
• [395] Protective role of HO-1 for alcohol-dependent liver damage. Dig Dis. 2010;28(6):792-8. doi: 10.1159/000324287. Epub 2011 Apr 27.
• [396] Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
• [397] Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease. J Neurosci. 2016 Jun 8;36(23):6332-51. doi: 10.1523/JNEUROSCI.0426-16.2016.
• [398] P21(Waf1/Cip1) plays a critical role in furazolidone-induced apoptosis in HepG2 cells through influencing the caspase-3 activation and ROS generation. Food Chem Toxicol. 2016 Feb;88:1-12. doi: 10.1016/j.fct.2015.12.004. Epub 2015 Dec 11.
• [399] Characterization of human liver thermostable phenol sulfotransferase (SULT1A1) allozymes with 3,3',5-triiodothyronine as the substrate. J Endocrinol. 2001 Dec;171(3):525-32.
• [400] Enzymatic characterization and interspecies difference of phenol sulfotransferases, ST1A forms. Drug Metab Dispos. 2001 Mar;29(3):274-81.
• [401] Sulfation of benzyl alcohol by the human cytosolic sulfotransferases (SULTs): a systematic analysis. J Appl Toxicol. 2016 Sep;36(9):1090-4.
• [402] Inhibition of human phenol and estrogen sulfotransferase by certain non-steroidal anti-inflammatory agents. Curr Drug Metab. 2006 Oct;7(7):745-53.
• [403] Methotrexate induction of human sulfotransferases in Hep G2 and Caco-2 cells. J Appl Toxicol. 2005 Sep-Oct;25(5):354-60.
• [404] Interindividual variability in 5-Fluorouracil metabolism and procainamide N-acetylation in human liver cytosol. Biol Pharm Bull. 2005 Jun;28(6):1071-4. doi: 10.1248/bpb.28.1071.
• [405] Eukaryotic arylamine N-acetyltransferase. Investigation of substrate specificity by high-throughput screening. Biochem Pharmacol. 2005 Jan 15;69(2):347-59. doi: 10.1016/j.bcp.2004.09.014. Epub 2004 Nov 24.
• [406] Association analysis of N-acetyl transferase-2 polymorphisms with aspirin intolerance among asthmatics. Pharmacogenomics. 2010 Jul;11(7):951-8. doi: 10.2217/pgs.10.65.
• [407] Analysis of nucleotide diversity of NAT2 coding region reveals homogeneity across Native American populations and high intra-population diversity. Pharmacogenomics J. 2007 Apr;7(2):144-52. doi: 10.1038/sj.tpj.6500407. Epub 2006 Jul 18.
• [408] The xenobiotic-metabolizing enzymes arylamine N-acetyltransferases in human lens epithelial cells: inactivation by cellular oxidants and UVB-induced oxidative stress. Mol Pharmacol. 2005 Apr;67(4):1299-306.
• [409] Simultaneous action of the flavonoid quercetin on cytochrome P450 (CYP) 1A2, CYP2A6, N-acetyltransferase and xanthine oxidase activity in healthy volunteers. Clin Exp Pharmacol Physiol. 2009 Aug;36(8):828-33.
• [410] Vitamin D3 transactivates the zinc and manganese transporter SLC30A10 via the Vitamin D receptor. J Steroid Biochem Mol Biol. 2016 Oct;163:77-87.
• [411] Over-expression, purification, and characterization of recombinant human arylamine N-acetyltransferase 1. Protein J. 2005 Feb;24(2):65-77.
• [412] Sulindac inhibited gene expression and activity of arylamine N-acetyltransferase and DNA-2-aminofluorene adduct formation in T24 human bladder tumor cells. Urol Res. 2001 Dec;29(6):406-11.
• [413] Type 5 17beta-hydroxysteroid dehydrogenase/prostaglandin F synthase (AKR1C3): role in breast cancer and inhibition by non-steroidal anti-inflammatory drug analogs. Chem Biol Interact. 2009 Mar 16;178(1-3):221-7.
• [414] Substrate specificity of human 3(20)alpha-hydroxysteroid dehydrogenase for neurosteroids and its inhibition by benzodiazepines. Biol Pharm Bull. 2002 Apr;25(4):441-5.
• [415] A new in vitro method for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells. Cutan Ocul Toxicol. 2010 Sep;29(3):171-92.
• [416] Aberrantly expressed genes in HaCaT keratinocytes chronically exposed to arsenic trioxide. Biomark Insights. 2011 Feb 8;6:7-16.
• [417] Thyroid hormone responsive genes in cultured human fibroblasts. J Clin Endocrinol Metab. 2005 Feb;90(2):936-43.
• [418] Progestin effects on expression of AKR1C1-AKR1C3, SRD5A1 and PGR in the Z-12 endometriotic epithelial cell line. Chem Biol Interact. 2013 Feb 25;202(1-3):218-25.
• [419] Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase. Cancer Res. 1999 Feb 1;59(3):607-14.
• [420] Initro inhibition of AKR1Cs by sulphonylureas and the structural basis. Chem Biol Interact. 2015 Oct 5;240:310-5.
• [421] Progestins as inhibitors of the human 20-ketosteroid reductases, AKR1C1 and AKR1C3. Chem Biol Interact. 2011 May 30;191(1-3):227-33.
• [422] AKR1C3 as a potential target for the inhibitory effect of dietary flavonoids. Chem Biol Interact. 2009 Mar 16;178(1-3):138-44.