Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM0RXBT)

• Drug Name: Beta-carotene Drug Info
• Synonyms: beta-carotene; 7235-40-7; beta Carotene; beta,beta-Carotene; Betacarotene; Provitamin A; Solatene; Carotaben; Provatene; all-trans-beta-Carotene; Serlabo; Natural Yellow 26; Karotin; KPMK; C.I. Food Orange 5; Solatene (caps); Karotin [Czech]; Food orange 5; Zlut prirodni 26; Betacarotenum [Latin]; Betacaroteno [Spanish]; Lucaratin; BetaVit; beta-Karotin; beta-Carotin; beta;-Carotene; beta-Carotene, all-trans-; .beta. Carotene; .beta.-Carotene; Betacarotenum [INN-Latin]; C.I. 75130; Betacaroteno [INN-Spanish]; Zlut prirodni 26 [Czech]

Indication

Disease Entry	ICD 11	Status	REF
Vitamin deficiency	5B55-5B71	Approved	[1]

• Cross-matching ID:
  PubChem CID: 5280489
  ChEBI ID: CHEBI:17579
  CAS Number: CAS 7235-40-7
  TTD Drug ID: DM0RXBT
  VARIDT Drug ID: DR01414
  INTEDE Drug ID: DR0204

Molecule-Related Drug Atlas

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[6]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[7]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[8]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[9]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[8]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[8]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[10]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[8]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[11]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[12]

Drug(s) Affected By Beta,beta-carotene 15,15'-dioxygenase (BCO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[13]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[14]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[16]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[17]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[18]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[19]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[20]
Ro 41-5253	DMSJLWP	Discovery agent	N.A.	Investigative	[13]

Drug(s) Affected By Cytochrome P450 26A1 (CYP26A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[21]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[21]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[22]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[23]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]
Dolutegravir	DMCZGRE	Human immunodeficiency virus infection	1C62	Approved	[25]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[21]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[26]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[27]
Bexarotene	DMOBIKY	Cutaneous T-cell lymphoma	2B01	Approved	[28]

Drug(s) Affected By Homeobox protein Meis2 (MEIS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[30]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[34]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[4]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[4]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]

Drug(s) Affected By Phospholipid scramblase 1 (PLSCR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[36]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[17]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[42]

Drug(s) Affected By Serine palmitoyltransferase 2 (SPTLC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[44]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[45]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[47]

Drug(s) Affected By CASP8 and FADD-like apoptosis regulator (CFLAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[48]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[49]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[50]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[55]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[57]

Drug(s) Affected By MutS protein homolog 5 (MSH5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[58]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[61]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[62]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[58]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[63]

Drug(s) Affected By Maleylacetoacetate isomerase (GSTZ1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[64]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[65]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[14]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[67]

Drug(s) Affected By DNA repair protein RAD51 homolog 4 (RAD51D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[68]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[69]

Drug(s) Affected By BAG family molecular chaperone regulator 4 (BAG4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[71]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[72]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[73]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[75]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[76]

Drug(s) Affected By Homeobox protein SIX6 (SIX6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[17]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[16]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[17]

Drug(s) Affected By BAG family molecular chaperone regulator 3 (BAG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[78]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[77]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[71]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[80]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[81]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[82]
Haloperidol	DM96SE0	Delirium		Approved	[83]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[84]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[85]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[86]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[87]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[88]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[89]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[90]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[91]

Drug(s) Affected By Interferon alpha-5 (IFNA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[92]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[93]

Drug(s) Affected By Interferon alpha-14 (IFNA14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[75]

Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[83]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[94]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[95]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[96]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[97]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[98]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[99]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[100]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[101]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[102]

Drug(s) Affected By Collagen alpha-1(IV) chain (COL4A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[104]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[106]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[107]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[108]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[105]

Drug(s) Affected By Integrin beta-1 (ITGB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[109]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[84]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[111]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[112]
Fructose	DM43AN2	Vomiting	MD90	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[114]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[115]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[116]

Drug(s) Affected By Keratin, type I cytoskeletal 18 (KRT18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[93]
Selenium	DM25CGV	N. A.	N. A.	Approved	[58]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[117]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[118]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[119]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[17]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[120]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[121]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[122]

Drug(s) Affected By Keratin, type II cytoskeletal 8 (KRT8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[58]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[118]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[123]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[17]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[125]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]

Drug(s) Affected By Alcohol dehydrogenase 1A (ADH1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[127]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[130]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[131]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[132]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[133]

Drug(s) Affected By Involucrin (IVL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[134]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[135]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[125]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[136]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[134]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[137]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[138]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[139]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[4]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[136]

Drug(s) Affected By Cathepsin B (CTSB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[140]
Selenium	DM25CGV	N. A.	N. A.	Approved	[58]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[141]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Pyrimethamine	DM5X7VY	Malaria	1F40-1F45	Approved	[142]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[143]
Propylthiouracil	DM6D7N8	Hyperthyroidism	5A02	Approved	[144]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[145]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[146]

Drug(s) Affected By Collagen alpha-2(IV) chain (COL4A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[147]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[65]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[147]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[4]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[106]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[107]

Drug(s) Affected By Keratin, type I cytoskeletal 19 (KRT19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Selenium	DM25CGV	N. A.	N. A.	Approved	[58]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[150]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[152]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[121]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]

Drug(s) Affected By Keratin, type II cytoskeletal 7 (KRT7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[153]
Selenium	DM25CGV	N. A.	N. A.	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[150]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[150]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[125]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[121]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[138]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[4]

Drug(s) Affected By Retinoic acid receptor alpha (RARA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[155]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[156]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[105]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[105]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[105]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[105]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[157]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[158]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[34]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[105]

Drug(s) Affected By Retinoic acid receptor beta (RARB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[159]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[160]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[17]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[161]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[34]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[162]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[163]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[4]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[107]

Drug(s) Affected By Cytochrome P450 2C9 (CYP2C9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[164]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[165]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[166]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[167]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[168]
Zafirlukast	DMHNQOG	Asthma	CA23	Approved	[169]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[166]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[170]
Fluconazole	DMOWZ6B	Cryptococcal meningitis		Approved	[167]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[166]

Drug(s) Affected By Alcohol dehydrogenase class-3 (ADH5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[171]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[172]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[173]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[62]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[174]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[175]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[176]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[177]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[178]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[179]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[114]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[17]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[180]

Drug(s) Affected By Integrin beta-4 (ITGB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[181]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[182]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[183]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[181]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[184]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[121]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[186]

Drug(s) Affected By Homeobox protein Hox-B6 (HOXB6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[172]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[187]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[27]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[188]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[189]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[190]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[191]

Drug(s) Affected By General transcription and DNA repair factor IIH helicase subunit XPD (ERCC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[192]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[193]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[194]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[195]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[194]

Drug(s) Affected By Protein-glutamine gamma-glutamyltransferase 2 (TGM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[196]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[197]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[198]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[199]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[200]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[131]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[201]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[202]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[203]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[204]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[205]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[206]
Fructose	DM43AN2	Vomiting	MD90	Approved	[113]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[207]
Vismodegib	DM5IXKQ	Basal cell carcinoma	2C32	Approved	[208]

Drug(s) Affected By Glutathione S-transferase Mu 2 (GSTM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[107]
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[209]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[210]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[211]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[61]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]

Drug(s) Affected By Nitric oxide synthase 1 (NOS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[212]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[213]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[214]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[213]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[215]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[71]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[216]
Bortezomib	DMNO38U	Leukemia		Approved	[217]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[218]
Interferon gamma-1b	DMWUMRL	Chronic granulomatous disease	4A00.0Y	Approved	[83]

Drug(s) Affected By Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (ALDH4A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[58]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[219]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[132]

Drug(s) Affected By Homeobox protein Hox-A7 (HOXA7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[220]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[221]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[58]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[75]

Drug(s) Affected By Guanylate-binding protein 1 (GBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[58]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[222]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[222]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[138]

Drug(s) Affected By Keratin, type II cytoskeletal 2 epidermal (KRT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[59]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[223]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[224]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[225]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[226]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[75]

Drug(s) Affected By Sterol regulatory element-binding protein 1 (SREBF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[124]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[83]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[227]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[128]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[228]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[229]
Vemurafenib	DM62UG5	Melanoma	2C30	Approved	[230]

Drug(s) Affected By Aldehyde dehydrogenase family 3 member B1 (ALDH3B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[107]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[231]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[73]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[190]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[232]

Drug(s) Affected By Glutathione S-transferase Mu 5 (GSTM5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[119]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[106]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[233]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[58]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[75]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[234]

Drug(s) Affected By Stromal cell-derived factor 1 (CXCL12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[235]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[65]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[17]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[235]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[237]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[238]
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[238]

Drug(s) Affected By Protein-glutamine gamma-glutamyltransferase 4 (TGM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[239]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[240]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[75]

Drug(s) Affected By Retinoic acid receptor responder protein 1 (RARRES1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[222]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[241]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[242]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[4]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[4]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[132]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[222]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[72]

Drug(s) Affected By Motor neuron and pancreas homeobox protein 1 (MNX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[239]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[17]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[60]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[75]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[93]

Drug(s) Affected By Homeobox protein MOX-1 (MEOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[243]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[243]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[243]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[17]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[243]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[243]
Ramelteon	DM7IW9J	Insomnia	7A00-7A0Z	Approved	[243]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[244]
Selenium	DM25CGV	N. A.	N. A.	Approved	[58]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[245]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[246]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[49]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[91]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[247]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[248]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[78]

Drug(s) Affected By Hepatocyte nuclear factor 3-alpha (FOXA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[155]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[172]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[249]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[250]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]

Drug(s) Affected By Claudin-18 (CLDN18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[60]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[61]
Coprexa	DMA0WEK	Neurological disorder	6B60	Phase 3	[251]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[75]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[93]

Drug(s) Affected By Gap junction alpha-9 protein (GJA9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[61]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[252]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[253]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[254]

Drug(s) Affected By C-X-C chemokine receptor type 4 (CXCR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[172]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[222]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[205]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[255]
Carfilzomib	DM48K0X	Multiple myeloma	2A83	Approved	[256]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[222]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[257]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[258]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[259]

Drug(s) Affected By Claudin-10 (CLDN10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[159]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[260]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[92]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[261]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[261]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[262]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[263]
Tetracycline	DMZA017	Acne vulgaris	ED80	Approved	[264]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[263]

Drug(s) Affected By Oxidized low-density lipoprotein receptor 1 (OLR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[265]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Aldosterone	DM9S2JW	Hypertension	BA00-BA04	Approved	[266]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[200]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[267]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[4]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[4]
Nifedipine	DMSVOZT	Angina pectoris	BA40	Approved	[268]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[73]

Drug(s) Affected By Iroquois-class homeodomain protein IRX-4 (IRX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[269]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[46]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[270]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[271]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[272]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[270]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[273]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[270]

Drug(s) Affected By Death domain-containing protein CRADD (CRADD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[274]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[107]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[275]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[276]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[277]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[174]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[93]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[278]

Drug(s) Affected By C-X-C motif chemokine 6 (CXCL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[149]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[186]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[279]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[132]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[280]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[252]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[281]
Vitamin C	DMXJ7O8	Adenocarcinoma	2D40	Approved	[282]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[283]

Drug(s) Affected By Mucin-5AC (MUC5AC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[284]
Selenium	DM25CGV	N. A.	N. A.	Approved	[285]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Ergotidine	DM78IME	Osteoarthritis	FA00-FA05	Approved	[286]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[287]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[4]
Dihydroxyacetone	DMM1LG2	Sunburn	EJ40	Approved	[288]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[4]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[289]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[290]

Drug(s) Affected By Ankyrin-2 (ANK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[131]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[270]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[270]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[231]

Drug(s) Affected By Interferon regulatory factor 8 (IRF8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[131]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[291]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[252]
Fenfluramine	DM0762O	Dravet syndrome	8A61.11	Phase 3	[292]
MK-2206	DMT1OZ6	Rectal adenocarcinoma	2B92	Phase 2	[293]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[294]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[295]

Drug(s) Affected By Glutathione S-transferase Mu 4 (GSTM4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[192]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]
Bortezomib	DMNO38U	Leukemia		Approved	[68]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[210]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[61]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[263]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[296]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[297]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 9 (TNFRSF9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[298]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[299]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[300]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[138]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[71]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[81]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[107]

Drug(s) Affected By C-X-C motif chemokine 9 (CXCL9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[301]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[302]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[303]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[154]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[304]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[138]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[303]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[305]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[306]

Drug(s) Affected By Homeobox protein DLX-2 (DLX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[79]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[307]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[308]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[16]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[309]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[310]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[311]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[312]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[313]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[314]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[315]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[316]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[110]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[317]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[318]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[319]

Drug(s) Affected By Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[320]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[321]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[49]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[322]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[205]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[323]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[324]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[56]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[325]

Drug(s) Affected By Ankyrin-3 (ANK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[93]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[14]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[326]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[327]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[172]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[72]

Drug(s) Affected By Acid ceramidase (ASAH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[328]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[329]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[330]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[328]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[329]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[328]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[329]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[328]

Drug(s) Affected By Transcription factor GATA-6 (GATA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[4]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[29]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[331]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[4]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[4]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[231]
Indomethacin	DMSC4A7	Bursitis		Approved	[332]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[172]

Drug(s) Affected By Homeobox protein DLX-4 (DLX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[172]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[333]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[192]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[334]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[335]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[231]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[276]

Drug(s) Affected By RAD51-associated protein 1 (RAD51AP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[124]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[336]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[337]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[338]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]

Drug(s) Affected By Ankyrin repeat and SOCS box protein 9 (ASB9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[172]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[338]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[231]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[17]

Drug(s) Affected By Protein lifeguard 2 (FAIM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[213]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[339]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[340]
Afimoxifene	DMFORDT	Breast cancer	2C60-2C65	Phase 2	[340]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[240]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[75]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[341]
4-[1-(4-hydroxyphenyl)-2-phenylbut-1-enyl]phenol	DMTMLXU	Discovery agent	N.A.	Investigative	[340]

Drug(s) Affected By Cytochrome P450 3A43 (CYP3A43)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[102]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[342]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[14]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[130]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[16]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[343]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[344]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[62]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[75]

Drug(s) Affected By Phospholipid scramblase 4 (PLSCR4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[345]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[106]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[173]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[346]
GSK2110183	DMZHB37	leukaemia	2A60-2B33	Phase 2	[347]

Drug(s) Affected By Phospholipid scramblase 3 (PLSCR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[348]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[349]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[75]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[341]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[350]

Drug(s) Affected By Homeobox protein Hox-C10 (HOXC10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[43]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[39]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[231]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[276]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[240]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[75]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[76]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[341]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[351]

Drug(s) Affected By LIM/homeobox protein Lhx3 (LHX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[44]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[68]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[231]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[253]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[254]

Drug(s) Affected By BAG family molecular chaperone regulator 5 (BAG5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[148]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[71]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[47]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[352]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[58]
EMODIN	DMAEDQG	Coronavirus Disease 2019 (COVID-19)	1D6Y	Terminated	[353]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[354]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[341]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[355]

Drug(s) Affected By Protocadherin gamma-C3 (PCDHGC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[58]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[356]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[185]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[27]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[357]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[231]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[74]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[358]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[58]

Drug(s) Affected By Glutathione S-transferase kappa 1 (GSTK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[359]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[224]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[275]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[188]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[225]
Isoflavone	DM7U58J	N. A.	N. A.	Phase 4	[360]

Drug(s) Affected By Ankyrin repeat and SOCS box protein 1 (ASB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[361]
Selenium	DM25CGV	N. A.	N. A.	Approved	[58]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[132]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[35]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[58]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[362]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[132]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[20]
Lithium chloride	DMHYLQ2	Discovery agent	N.A.	Investigative	[363]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[364]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[364]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[365]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[366]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[364]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[364]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[364]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[367]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[368]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[369]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[311]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[370]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[371]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[372]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[83]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[313]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[314]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[373]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[320]
Flucytosine	DM13VTW	Cryptococcal meningitis		Approved	[374]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[375]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[376]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[377]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[378]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[316]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[379]
Selenium	DM25CGV	N. A.	N. A.	Approved	[58]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[380]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[381]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[182]

Drug(s) Affected By Mitogen-activated protein kinase 3 (MAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[382]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[383]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[384]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[320]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[385]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[386]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[387]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[388]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[389]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[390]

Drug(s) Affected By Mitogen-activated protein kinase 1 (MAPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[391]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[383]
Carvedilol	DMHTEAO	Chronic heart failure	BD1Z	Approved	[392]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[393]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[394]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[382]
Urokinase	DM0GOUD	Myocardial infarction	BA41-BA43	Approved	[83]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[109]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[320]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[385]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[395]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[396]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[397]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[398]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[399]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[400]
Selenium	DM25CGV	N. A.	N. A.	Approved	[58]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[401]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[380]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[402]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[403]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[404]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[405]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[406]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[407]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[408]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[409]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[410]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[411]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[312]

Drug(s) Affected By Caveolin-1 (CAV1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[155]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[387]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[412]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[413]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[414]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[415]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[416]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]

Drug(s) Affected By Transcription factor p65 (RELA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[109]
Selenium	DM25CGV	N. A.	N. A.	Approved	[58]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[417]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[418]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[419]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[29]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[420]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[421]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[422]
Desloratadine	DM56YN7	Allergic rhinitis	CA08.0	Approved	[423]

Drug(s) Affected By Methylated-DNA--protein-cysteine methyltransferase (MGMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[424]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[425]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[426]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[427]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[41]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[428]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[429]
Dacarbazine	DMNPZL4	Adenocarcinoma	2D40	Approved	[430]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[431]

Drug(s) Affected By Thrombomodulin (THBD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[132]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[356]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[183]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[151]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[121]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[15]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[432]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[433]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[231]

Drug(s) Affected By Scavenger receptor class B member 1 (SCARB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[434]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[435]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[436]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[102]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[103]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[437]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[438]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[439]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[24]

Molecular Interaction Atlas of This Drug

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[2]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Beta,beta-carotene 15,15'-dioxygenase (BCO1) Main DME	DE6BOK3	BCDO1_HUMAN	Substrate	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Acid ceramidase (ASAH1)	OT1DNGXL	ASAH1_HUMAN	Gene/Protein Processing	[4]
Alcohol dehydrogenase 1A (ADH1A)	OTTS983E	ADH1A_HUMAN	Gene/Protein Processing	[4]
Alcohol dehydrogenase class-3 (ADH5)	OTSO67MI	ADHX_HUMAN	Gene/Protein Processing	[4]
Aldehyde dehydrogenase family 3 member B1 (ALDH3B1)	OT5NEUQE	AL3B1_HUMAN	Gene/Protein Processing	[4]
Ankyrin repeat and SOCS box protein 1 (ASB1)	OT0NZGEI	ASB1_HUMAN	Gene/Protein Processing	[4]
Ankyrin repeat and SOCS box protein 9 (ASB9)	OT3AA61T	ASB9_HUMAN	Gene/Protein Processing	[4]
Ankyrin-2 (ANK2)	OTWB4R1Y	ANK2_HUMAN	Gene/Protein Processing	[4]
Ankyrin-3 (ANK3)	OTJ3IRBP	ANK3_HUMAN	Gene/Protein Processing	[4]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[4]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[5]

References

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• [11] Antiestrogens and steroid hormones: substrates of the human P-glycoprotein. Biochem Pharmacol. 1994 Jul 19;48(2):287-92.
• [12] Association of genetic polymorphisms in the influx transporter SLCO1B3 and the efflux transporter ABCB1 with imatinib pharmacokinetics in patients with chronic myeloid leukemia. Ther Drug Monit. 2011 Apr;33(2):244-50.
• [13] Beta-Carotene conversion into vitamin A in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2005 Oct;46(10):3562-9.
• [14] Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
• [15] Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
• [16] Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
• [17] A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
• [18] Identification of a transcriptomic signature of food-relevant genotoxins in human HepaRG hepatocarcinoma cells. Food Chem Toxicol. 2020 Jun;140:111297. doi: 10.1016/j.fct.2020.111297. Epub 2020 Mar 28.
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