Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM4ZS8M)

• Drug Name: Nefazodone Drug Info
• Synonyms: Nefazodona; Nefazodonum; Nefazodona [Spanish]; Nefazodone Hcl; Nefazodonum [Latin]; Nefadar (TN); Nefazodone (INN); Nefazodone [INN:BAN]; Serzone (TN); 1-(3-(4-(3-Chlorpheyl-1-piperazinylpropyl)-3-ethyl-4,5-dihydro-4-(2-phenoxyethyl)-1,2,4-triazol-5-on; 1-(3-(4-(m-Chlorophenyl)-1-piperazinyl)propyl)-3-ethyl-4-(2-phenoxyethyl)-delta2-1,2,4-triazolin-5-one; 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one; 2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-5-ethyl-4-(2-phenoxyethyl)-1,2,4-triazol-3-one; 2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-5-ethyl-4-(2-phenoxyethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one; 2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-5-ethyl-4-[2-(phenyloxy)ethyl]-2,4-dihydro-3H-1,2,4-triazol-3-one

Indication

Disease Entry	ICD 11	Status	REF
Major depressive disorder	6A70.3	Approved	[1]
Depression	6A70-6A7Z	Withdrawn from market	[2]

• Therapeutic Class: Antidepressants
• Cross-matching ID:
  PubChem CID: 4449
  ChEBI ID: CHEBI:7494
  CAS Number: CAS 83366-66-9
  TTD Drug ID: DM4ZS8M
  VARIDT Drug ID: DR00468
  INTEDE Drug ID: DR1135
  ACDINA Drug ID: D00460

Molecule-Related Drug Atlas

Drug(s) Targeting 5-HT 2C receptor (HTR2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metergolin	DMJFP6G	Hyperprolactinaemia	5A60.1	Approved	[10]
Lorcaserin	DMG6OYJ	Obesity	5B81	Approved	[11]
Tramadol	DMRQD04	Osteoarthritis	FA00-FA05	Approved	[12]
Mirtazapine	DML53ZJ	Depression	6A70-6A7Z	Approved	[6]
Methysergide	DM1EF73	Migraine	8A80	Approved	[13]
Eltoprazine	DMW6C81	Attention deficit hyperactivity disorder	6A05.Z	Phase 3	[14]
M100907	DM7ZFBA	Sleep-wake disorder	7A00-7B2Z	Phase 3	[15]
SR46349B	DM1ODMR	Primary insomnia	7A00	Phase 3	[16]
Vabicaserin	DM9GZW6	Psychotic disorder	6A20-6A25	Phase 2	[17]
Nuplazid	DMOJA5G	Alzheimer disease	8A20	Phase 2	[18]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[19]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[20]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[21]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[22]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[23]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[24]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[25]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[26]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[20]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[27]
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[36]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[37]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[38]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[39]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[40]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[40]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[41]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[42]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[43]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[44]

Drug(s) Metabolized By Cytochrome P450 2D6 (CYP2D6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[28]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[29]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[30]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[23]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[27]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[31]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[32]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[33]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[34]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[35]

Drug(s) Affected By 5-hydroxytryptamine receptor 2C (HTR2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[6]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[6]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[45]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Nortriptyline	DM4KDYJ	Depression	6A70-6A7Z	Approved	[47]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[48]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Clomipramine	DMINRKW	Depression	6A70-6A7Z	Approved	[6]

Drug(s) Affected By Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PIK3C2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[56]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[58]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[59]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[60]

Drug(s) Affected By Ectoderm-neural cortex protein 1 (ENC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[61]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[62]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[64]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[67]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]

Drug(s) Affected By Proepiregulin (EREG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[69]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[8]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[58]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[8]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[8]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[73]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[8]

Drug(s) Affected By ATP-binding cassette sub-family C member 3 (ABCC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[74]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[75]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[76]
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[77]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[78]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[79]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[58]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[80]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[81]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[82]

Drug(s) Affected By ATP-binding cassette sub-family C member 4 (ABCC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[83]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[84]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[85]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[86]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[87]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[54]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[89]

Drug(s) Affected By Transcription factor MafG (MAFG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[78]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[65]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[92]

Drug(s) Affected By Forkhead box protein O3 (FOXO3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[94]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[95]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[96]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[97]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[98]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[99]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[64]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]

Drug(s) Affected By Transcription factor MafK (MAFK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[101]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[56]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[102]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[103]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[104]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[105]

Drug(s) Affected By Auxilin (DNAJC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[107]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[108]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[102]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[60]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[107]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[109]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[104]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[110]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[110]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[111]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[112]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[113]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[110]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[110]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[110]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[114]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[115]

Drug(s) Affected By Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma (PIK3C2G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[116]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Atazanavir	DMSYRBX	Human immunodeficiency virus infection	1C62	Approved	[7]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[108]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[102]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[117]

Drug(s) Affected By Aflatoxin B1 aldehyde reductase member 3 (AKR7A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[118]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[56]
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[119]
Atazanavir	DMSYRBX	Human immunodeficiency virus infection	1C62	Approved	[7]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[50]
EMODIN	DMAEDQG	Coronavirus Disease 2019 (COVID-19)	1D6Y	Terminated	[120]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[121]
7-hydroxycoumarin	DMTMNO7	Discovery agent	N.A.	Investigative	[122]

Drug(s) Affected By Bile salt export pump (ABCB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[123]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[124]
Glipizide	DMZA5PQ	Diabetic complication	5A2Y	Approved	[124]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[125]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[123]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[124]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[126]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[123]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[127]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[123]

Drug(s) Affected By Ubiquitin-like modifier-activating enzyme ATG7 (ATG7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[128]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[129]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[132]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[133]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[7]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[134]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[89]

Drug(s) Affected By Cytochrome c oxidase subunit 1 (COX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zalcitabine	DMH7MUV	Human immunodeficiency virus infection	1C62	Approved	[135]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[136]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[137]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[89]
Chloramphenicol	DMFXEWT	Bacterial infection	1A00-1C4Z	Approved	[139]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[140]
Nicotinamide	DMUPE07	Acne vulgaris	ED80	Approved	[136]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[60]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[141]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[142]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[143]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[144]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[143]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[79]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[145]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[146]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[147]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[148]

Drug(s) Affected By Interleukin-1 alpha (IL1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[149]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[8]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[8]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[150]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[8]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[151]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[152]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[8]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[153]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[154]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[155]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[156]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[8]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[157]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[8]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[158]
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[160]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[161]

Drug(s) Affected By NADH-ubiquinone oxidoreductase chain 5 (ND5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[162]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[163]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[164]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[89]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[56]
INX-189	DMSTJ6Q	Hepatitis C virus infection	1E51.1	Phase 2	[165]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[166]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[167]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[168]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[169]

Drug(s) Affected By ATP synthase protein 8 (ATP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[164]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[170]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[167]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[169]
methyl p-hydroxybenzoate	DMO58UW	Discovery agent	N.A.	Investigative	[171]

Drug(s) Affected By Antileukoproteinase (SLPI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[8]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[8]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[58]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[8]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[8]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[8]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[8]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[8]

Drug(s) Affected By Catalase (CAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[157]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[172]
Haloperidol	DM96SE0	Delirium		Approved	[173]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[174]
Selenium	DM25CGV	N. A.	N. A.	Approved	[175]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[176]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[177]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[151]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[178]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[179]
Selenium	DM25CGV	N. A.	N. A.	Approved	[159]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[180]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[181]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[182]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[183]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[184]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[63]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[185]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[186]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[187]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[188]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[189]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[190]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[191]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[153]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[192]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[193]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[194]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[195]

Drug(s) Affected By Plasminogen activator inhibitor 1 (SERPINE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[196]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[61]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[197]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[198]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[199]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[200]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[63]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[201]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[202]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[137]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[203]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[204]
Fructose	DM43AN2	Vomiting	MD90	Approved	[173]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[205]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[206]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[144]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[207]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[208]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[209]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[210]

Drug(s) Affected By Epoxide hydrolase 1 (EPHX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[211]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[212]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[213]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[137]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[214]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[89]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[215]

Drug(s) Affected By Glutathione S-transferase A1 (GSTA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[216]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[217]
Thiotepa	DMIZKOP	Breast cancer	2C60-2C65	Approved	[218]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[219]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[220]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[221]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[222]
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[223]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[58]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[224]

Drug(s) Affected By Hepatocyte growth factor receptor (MET)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cabozantinib	DMIYDT4	Medullary thyroid gland carcinoma		Approved	[225]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[226]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[8]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[8]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[8]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[180]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[227]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[180]

Drug(s) Affected By 5-hydroxytryptamine receptor 1A (HTR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Trazodone	DMK1GBJ	Depression	6A70-6A7Z	Approved	[5]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[228]
Methamphetamine	DMPM4SK	Anxiety		Approved	[229]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[230]
Perospirone	DMVHJLX	Psychotic disorder	6A20-6A25	Approved	[230]
Etoperidone	DMR7U8F	N. A.	N. A.	Phase 4	[5]
phorbol 12-myristate 13-acetate	DMJWD62	Acute myeloid leukaemia	2A60	Phase 2	[231]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[117]
DU 125530	DM63UA9	Mood disorder	6A60-6E23	Discontinued in Phase 2	[232]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[231]

Drug(s) Affected By Macrophage colony-stimulating factor 1 (CSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[207]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[233]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[234]
Selenium	DM25CGV	N. A.	N. A.	Approved	[235]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[236]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[48]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[49]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[65]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[237]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[238]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[239]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[240]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[206]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[155]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[8]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[157]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[241]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[8]

Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[242]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[243]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[244]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[245]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[246]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[247]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[248]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[249]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[250]

Drug(s) Affected By Ras-related protein Ral-A (RALA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[251]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[252]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[141]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[253]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[89]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[254]
Bortezomib	DMNO38U	Leukemia		Approved	[255]

Drug(s) Affected By Proliferating cell nuclear antigen (PCNA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[149]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[79]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[256]
Selenium	DM25CGV	N. A.	N. A.	Approved	[257]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[258]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[259]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[260]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[70]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[261]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[262]

Drug(s) Affected By Fos-related antigen 1 (FOSL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[61]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[263]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[264]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[265]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[266]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[267]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[65]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[92]

Drug(s) Affected By Transcription factor JunD (JUND)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[206]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[144]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[145]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[268]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[269]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[99]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[270]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[271]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[267]

Drug(s) Affected By Glutathione peroxidase 2 (GPX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[78]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[272]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[63]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[273]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[274]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[275]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[266]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[48]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-4 (ATF4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[144]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[276]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[145]
Selenium	DM25CGV	N. A.	N. A.	Approved	[235]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[268]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[277]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[278]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[279]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[280]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[281]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-6 alpha (ATF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[243]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[282]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[243]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Pyrazinamide	DM4IF32	Meningeal tuberculosis		Approved	[277]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[283]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[243]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[284]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[285]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[286]

Drug(s) Affected By Cytochrome P450 2B6 (CYP2B6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[287]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[288]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[289]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[290]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[291]
Clopidogrel	DMOL54H	Acute coronary syndrome	BA41	Approved	[292]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[293]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[294]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[295]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[296]

Drug(s) Affected By Phosphatidylcholine translocator ABCB4 (ABCB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[297]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[298]
Methysergide	DM1EF73	Migraine	8A80	Approved	[126]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[272]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[224]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[126]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[63]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[299]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[289]

Drug(s) Affected By Bone morphogenetic protein 6 (BMP6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[8]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[8]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[300]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[8]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[8]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[8]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[301]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[8]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[49]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[302]

Drug(s) Affected By Cytochrome P450 7A1 (CYP7A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcipotriol	DM03CP7	Psoriasis	EA90	Approved	[77]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[272]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[224]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[303]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[304]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[153]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[305]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[295]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[303]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[306]

Drug(s) Affected By DnaJ homolog subfamily B member 1 (DNAJB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[307]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[308]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[156]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[309]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[99]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[310]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[311]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[267]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[65]

Drug(s) Affected By Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[312]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[313]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[97]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[314]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[315]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[316]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[317]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Cantharidin	DMBP5N3	Molluscum contagiosum infection	1E76	Approved	[318]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[308]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[319]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[144]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[276]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[243]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[246]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[320]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[321]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]

Drug(s) Affected By C-C chemokine receptor type 2 (CCR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[224]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[322]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[323]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[324]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[325]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[326]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[327]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[328]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[329]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[330]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[331]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[332]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[333]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[334]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[335]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[336]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[337]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[338]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[339]

Drug(s) Affected By Caspase-7 (CASP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[340]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[144]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[341]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[342]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[343]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[343]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[70]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[344]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[345]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[346]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[347]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[348]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[149]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[349]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[350]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[351]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[352]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[353]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[354]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[355]

Drug(s) Affected By Ras-related protein Rap-1A (RAP1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[356]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[357]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[358]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Minodronate	DM50PMY	Osteoporosis	FB83.0	Approved	[359]
Risedronate	DM5FLTY	Bone Paget disease		Approved	[360]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[361]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[362]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[360]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[363]

Drug(s) Affected By Flavin-containing monooxygenase 1 (FMO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[145]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[153]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[364]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[106]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Dihydroxyacetone	DMM1LG2	Sunburn	EJ40	Approved	[365]
Atazanavir	DMSYRBX	Human immunodeficiency virus infection	1C62	Approved	[7]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[366]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[367]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[368]

Drug(s) Affected By Aldehyde oxidase (AOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[224]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[184]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[180]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[369]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[215]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[55]

Drug(s) Affected By Sulfotransferase 2A1 (SULT2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[233]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[224]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[370]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[370]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[371]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[164]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[372]

Drug(s) Affected By Potassium voltage-gated channel subfamily H member 2 (KCNH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Metoclopramide	DMFA5MY	Nausea	MD90	Approved	[373]
Quinidine	DMLPICK	N. A.	N. A.	Approved	[374]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[375]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[376]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[376]
Disopyramide	DM5SYZP	Long QT syndrome	BC65.0	Approved	[377]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[378]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[379]
Dofetilide	DMPN1TW	Sinus rhythm disorder	BC9Y	Approved	[380]
Flecainide	DMSQDLE	Tachyarrhythmias	BC71	Approved	[376]

Drug(s) Affected By Interleukin-24 (IL24)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[149]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[8]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[155]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[8]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[8]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[381]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[370]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[8]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[370]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[382]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[383]
Tibolone	DM78XFG	Anabolic metabolism	5C50-5C8Z	Approved	[384]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[48]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[48]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[385]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[386]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[387]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[388]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[389]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[390]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[233]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[391]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[268]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[392]

Drug(s) Affected By Serine/threonine-protein kinase ATR (ATR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[99]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[393]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[394]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[395]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[99]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[56]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[396]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[328]

Drug(s) Affected By Receptor-interacting serine/threonine-protein kinase 1 (RIPK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[388]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[397]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[7]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[89]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[398]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[399]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Bortezomib	DMNO38U	Leukemia		Approved	[400]

Drug(s) Affected By Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[308]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[401]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[352]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[402]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[403]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[404]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[364]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[405]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[99]

Drug(s) Affected By Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[406]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[224]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[407]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Retigabine	DMGNYIH	Behcet disease	4A62	Approved	[408]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[215]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[108]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[60]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[409]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[410]

Drug(s) Affected By Sodium channel protein type 5 subunit alpha (SCN5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Disopyramide	DM5SYZP	Long QT syndrome	BC65.0	Approved	[173]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[411]
Flecainide	DMSQDLE	Tachyarrhythmias	BC71	Approved	[412]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[413]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[414]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[407]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[415]
Retigabine	DMGNYIH	Behcet disease	4A62	Approved	[408]
Luvox	DMJKROX	Anxiety disorder	6B00-6B0Z	Approved	[416]

Drug(s) Affected By Hepatic sodium/bile acid cotransporter (SLC10A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[272]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[304]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[273]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[417]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[418]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[419]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[420]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[273]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[114]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[421]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[299]
Artemether	DM48QOT	Malaria	1F40-1F45	Approved	[422]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[423]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[424]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[425]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[426]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[425]

Drug(s) Affected By Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (HERPUD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[308]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[144]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[427]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[311]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[137]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[428]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Racecadotril	DMFOTZ7	Diarrhea	ME05.1	Approved	[429]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[430]

Drug(s) Affected By MAP kinase-activated protein kinase 3 (MAPKAPK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[281]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[363]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[431]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]
Atazanavir	DMSYRBX	Human immunodeficiency virus infection	1C62	Approved	[7]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[432]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[104]

Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[188]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[90]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[433]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[434]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[435]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[436]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[437]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[438]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[439]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[240]

Drug(s) Affected By Glutathione S-transferase A3 (GSTA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[141]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[7]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[56]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[440]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[58]
Atazanavir	DMSYRBX	Human immunodeficiency virus infection	1C62	Approved	[7]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[441]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[442]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[217]

Drug(s) Affected By DnaJ homolog subfamily C member 21 (DNAJC21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[107]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[108]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[443]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[60]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[107]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[444]
APR-246	DMNFADH	Ovarian cancer	2C73	Phase 2	[445]

Drug(s) Affected By PTB-containing, cubilin and LRP1-interacting protein (PID1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[8]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[8]
Penbutolol	DM4ES8F	Hypertension	BA00-BA04	Approved	[8]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[8]
Amikacin	DM5PDRB	Bacteremia	1A73	Approved	[8]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[8]
Promethazine	DM6I5GR	Hyperemesis gravidarum		Approved	[8]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[8]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Trihexyphenidyl	DMB19L8	Dystonia	8A02	Approved	[8]

Drug(s) Affected By DnaJ homolog subfamily C member 10 (DNAJC10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[446]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[447]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[89]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[56]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[107]
Atazanavir	DMSYRBX	Human immunodeficiency virus infection	1C62	Approved	[7]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[107]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[448]

Drug(s) Affected By Mixed lineage kinase domain-like protein (MLKL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[63]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[449]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[450]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[273]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[451]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[56]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[452]

Drug(s) Affected By Phosphatidylinositol 3-kinase catalytic subunit type 3 (PIK3C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[224]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[130]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[314]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[266]
Ceritinib	DMB920Z	Non-small-cell lung cancer	2C25.Y	Approved	[453]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[89]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[454]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[455]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[455]

Drug(s) Affected By Mitochondrial import inner membrane translocase subunit TIM14 (DNAJC19)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[362]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[456]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[56]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[457]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[60]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[458]

Drug(s) Affected By DnaJ homolog subfamily C member 1 (DNAJC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[459]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[460]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[56]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[328]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[102]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[104]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[461]

Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[58]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[352]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[268]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[402]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[462]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[261]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[364]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[463]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[464]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[465]

Drug(s) Affected By Bile acid receptor (NR1H4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[401]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[466]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[419]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[467]
Nisoldipine	DM7ISKJ	Hypertension	BA00-BA04	Approved	[466]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[419]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[468]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[469]

Drug(s) Affected By Microsomal glutathione S-transferase 2 (MGST2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[470]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[89]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[68]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[56]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[452]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[57]

Drug(s) Affected By Eukaryotic translation initiation factor 2A (EIF2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[276]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[459]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[382]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[471]
Cerulenin	DM6N4PR	Weight loss	MG43.5	Approved	[472]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[267]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[395]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[89]

Drug(s) Affected By Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[389]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[312]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[70]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[473]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[474]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[131]
Trovafloxacin	DM6AN32	Acute gonococcal cervicitis		Approved	[475]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[285]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[476]

Drug(s) Affected By Ubiquitin carboxyl-terminal hydrolase CYLD (CYLD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[388]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[53]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[270]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[362]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[363]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[328]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[477]
Atazanavir	DMSYRBX	Human immunodeficiency virus infection	1C62	Approved	[7]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[102]

Drug(s) Affected By DnaJ homolog subfamily B member 9 (DNAJB9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[308]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[311]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[308]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[92]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[92]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[428]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[478]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[92]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[67]

Drug(s) Affected By Transcription factor MafF (MAFF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[78]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[251]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[58]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[479]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[71]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[63]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[72]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[46]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[116]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[480]

Drug(s) Affected By Endophilin-B1 (SH3GLB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[48]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[48]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[65]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[50]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[89]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[56]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[107]
Atazanavir	DMSYRBX	Human immunodeficiency virus infection	1C62	Approved	[7]

Drug(s) Affected By Solute carrier organic anion transporter family member 1B1 (SLCO1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[481]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[482]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[125]
Repaglinide	DM5SXUV	Diabetic complication	5A2Y	Approved	[483]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[484]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[485]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[486]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[486]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[487]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[488]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 2C receptor (HTR2C)	TTWJBZ5	5HT2C_HUMAN	Antagonist	[3]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[4]
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Substrate	[4]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
5-hydroxytryptamine receptor 1A (HTR1A)	OT38K9MK	5HT1A_HUMAN	Protein Interaction/Cellular Processes	[5]
5-hydroxytryptamine receptor 2C (HTR2C)	OT6H8DE0	5HT2C_HUMAN	Protein Interaction/Cellular Processes	[6]
Aflatoxin B1 aldehyde reductase member 3 (AKR7A3)	OTW3GO4Y	ARK73_HUMAN	Gene/Protein Processing	[7]
Aldehyde oxidase (AOX1)	OT2FZP6H	AOXA_HUMAN	Gene/Protein Processing	[7]
Antileukoproteinase (SLPI)	OTUNFUU8	SLPI_HUMAN	Gene/Protein Processing	[8]
ATP synthase protein 8 (ATP8)	OTYQQR53	ATP8_HUMAN	Gene/Protein Processing	[9]
ATP-binding cassette sub-family C member 3 (ABCC3)	OTC3IJV4	MRP3_HUMAN	Gene/Protein Processing	[7]
ATP-binding cassette sub-family C member 4 (ABCC4)	OTO27PAL	MRP4_HUMAN	Gene/Protein Processing	[7]
Auxilin (DNAJC6)	OT1P6ZIE	AUXI_HUMAN	Gene/Protein Processing	[7]
Bcl-2-binding component 3, isoforms 3/4 (BBC3)	OTUAXDAY	BBC3B_HUMAN	Gene/Protein Processing	[9]

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7247).
• [3] Serotonin 5-HT2C receptors as a target for the treatment of depressive and anxious states: focus on novel therapeutic strategies. Therapie. 2005 Sep-Oct;60(5):441-60.
• [4] Nefazodone, meta-chlorophenylpiperazine, and their metabolites in vitro: cytochromes mediating transformation, and P450-3A4 inhibitory actions. Psychopharmacology (Berl). 1999 Jul;145(1):113-22.
• [5] Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. doi: 10.1007/BF02244985.
• [6] Inverse agonist and neutral antagonist actions of antidepressants at recombinant and native 5-hydroxytryptamine2C receptors: differential modulatio... Mol Pharmacol. 2008 Mar;73(3):748-57.
• [7] Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury. Arch Toxicol. 2020 Apr;94(4):1151-1172. doi: 10.1007/s00204-020-02691-9. Epub 2020 Mar 10.
• [8] An in vitro coculture system of human peripheral blood mononuclear cells with hepatocellular carcinoma-derived cells for predicting drug-induced liver injury. Arch Toxicol. 2021 Jan;95(1):149-168. doi: 10.1007/s00204-020-02882-4. Epub 2020 Aug 20.
• [9] Involvement of mitochondrial dysfunction in nefazodone-induced hepatotoxicity. Food Chem Toxicol. 2016 Aug;94:148-58. doi: 10.1016/j.fct.2016.06.001. Epub 2016 Jun 8.
• [10] Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn Schmiedebergs Arch Pharmacol. 2004 Aug;370(2):114-23.
• [11] Anti-obesity drugs. Expert Opin Pharmacother. 2008 Jun;9(8):1339-50.
• [12] The inhibitory effects of tramadol on 5-hydroxytryptamine type 2C receptors expressed in Xenopus oocytes. Anesth Analg. 2004 May;98(5):1401-6, table of contents.
• [13] Spinal serotonin receptor activation modulates the exercise ventilatory response with increased dead space in goats. Respir Physiol Neurobiol. 2008 May 31;161(3):230-8.
• [14] Clinical pipeline report, company report or official report of Jazz Pharmaceuticals.
• [15] Non-basic ligands for aminergic GPCRs: the discovery and development diaryl sulfones as selective, orally bioavailable 5-HT2A receptor antagonists ... Bioorg Med Chem Lett. 2010 Jun 15;20(12):3708-12.
• [16] SR46349-B, a 5-HT(2A/2C) receptor antagonist, potentiates haloperidol-induced dopamine release in rat medial prefrontal cortex and nucleus accumbens. Neuropsychopharmacology. 2002 Sep;27(3):430-41.
• [17] Prediction of Efficacy of Vabicaserin, a 5-HT2C Agonist, for the Treatment of Schizophrenia Using a Quantitative Systems Pharmacology Model.CPT Pharmacometrics Syst Pharmacol.2014 Apr 23;3:e111.
• [18] The neuropharmacology of sleep paralysis hallucinations: serotonin 2A activation and a novel therapeutic drug. Psychopharmacology (Berl). 2018 Nov;235(11):3083-3091.
• [19] Expression levels and activation of a PXR variant are directly related to drug resistance in osteosarcoma cell lines. Cancer. 2007 Mar 1;109(5):957-65.
• [20] Contribution of human hepatic cytochrome P450 isoforms to regioselective hydroxylation of steroid hormones. Xenobiotica. 1998 Jun;28(6):539-47.
• [21] Comprehensive evaluation of tamoxifen sequential biotransformation by the human cytochrome P450 system in vitro: prominent roles for CYP3A and CYP2D6. J Pharmacol Exp Ther. 2004 Sep;310(3):1062-75.
• [22] Isoform-specific regulation of cytochromes P450 expression by estradiol and progesterone. Drug Metab Dispos. 2013 Feb;41(2):263-9.
• [23] Metabolic interactions between acetaminophen (paracetamol) and two flavonoids, luteolin and quercetin, through in-vitro inhibition studies. J Pharm Pharmacol. 2017 Dec;69(12):1762-1772.
• [24] Potent mechanism-based inhibition of CYP3A4 by imatinib explains its liability to interact with CYP3A4 substrates. Br J Pharmacol. 2012 Apr;165(8):2787-98.
• [25] Effects of morin on the pharmacokinetics of etoposide in rats. Biopharm Drug Dispos. 2007 Apr;28(3):151-6.
• [26] The metabolism of zidovudine by human liver microsomes in vitro: formation of 3'-amino-3'-deoxythymidine. Biochem Pharmacol. 1994 Jul 19;48(2):267-76.
• [27] Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
• [28] Inhibitory effects of anticancer drugs on dextromethorphan-O-demethylase activity in human liver microsomes. Cancer Chemother Pharmacol. 1993;32(6):491-5.
• [29] Effect of genetic polymorphism on the metabolism of endogenous neuroactive substances, progesterone and p-tyramine, catalyzed by CYP2D6. Brain Res Mol Brain Res. 2004 Oct 22;129(1-2):117-23.
• [30] CYP2D6 polymorphisms and tamoxifen metabolism: clinical relevance. Curr Oncol Rep. 2010 Jan;12(1):7-15.
• [31] Inhibition of cytochrome P450 2D6: structure-activity studies using a series of quinidine and quinine analogues. Chem Res Toxicol. 2003 Apr;16(4):450-9.
• [32] Effects of propofol on human hepatic microsomal cytochrome P450 activities. Xenobiotica. 1998 Sep;28(9):845-53.
• [33] Pharmacogenetics of schizophrenia. Am J Med Genet. 2000 Spring;97(1):98-106.
• [34] Roles of CYP2A6 and CYP2B6 in nicotine C-oxidation by human liver microsomes. Arch Toxicol. 1999 Mar;73(2):65-70.
• [35] Structure-activity relationship for human cytochrome P450 substrates and inhibitors. Drug Metab Rev. 2002 Feb-May;34(1-2):69-82.
• [36] The relative role of CYP3A4 and CYP3A5 in eplerenone metabolism. Toxicol Lett. 2019 Oct 15;315:9-13.
• [37] Characterization of the structural determinants required for potent mechanism-based inhibition of human cytochrome P450 1A1 by cannabidiol. Chem Biol Interact. 2014 May 25;215:62-8.
• [38] Retinoids activate the RXR/SXR-mediated pathway and induce the endogenous CYP3A4 activity in Huh7 human hepatoma cells. Toxicol Sci. 2006 Jul;92(1):51-60.
• [39] The novel azole R126638 is a selective inhibitor of ergosterol synthesis in Candida albicans, Trichophyton spp., and Microsporum canis. Antimicrob Agents Chemother. 2004 Sep;48(9):3272-8.
• [40] Application of higher throughput screening (HTS) inhibition assays to evaluate the interaction of antiparasitic drugs with cytochrome P450s. Drug Metab Dispos. 2001 Jan;29(1):30-5.
• [41] Cetirizine and loratadine-based antihistamines with 5-lipoxygenase inhibitory activity. Bioorg Med Chem Lett. 2004 Nov 15;14(22):5591-4.
• [42] Mechanism-based inactivation of CYP3A by HIV protease inhibitors. J Pharmacol Exp Ther. 2005 Feb;312(2):583-91.
• [43] Studies of the toxicological potential of capsinoids, XIII: inhibitory effects of capsaicin and capsinoids on cytochrome P450 3A4 in human liver microsomes. Int J Toxicol. 2010 Mar;29(2 Suppl):22S-6S.
• [44] Investigation of the effects of axitinib on the pharmacokinetics of loperamide and its main metabolite N-demethylated loperamide in rats by UPLC-MS/MS. Chem Biol Interact. 2019 Sep 1;310:108744. doi: 10.1016/j.cbi.2019.108744. Epub 2019 Jul 9.
• [45] Discovery of antiandrogen activity of nonsteroidal scaffolds of marketed drugs. Proc Natl Acad Sci U S A. 2007 Jul 17;104(29):11927-32. doi: 10.1073/pnas.0609752104. Epub 2007 Jul 2.
• [46] Development of a neural teratogenicity test based on human embryonic stem cells: response to retinoic acid exposure. Toxicol Sci. 2011 Dec;124(2):370-7.
• [47] Downregulation of serotonin receptor subtypes by nortriptyline and adinazolam in major depressive disorder: neuroendocrine and platelet markers. Clin Neuropharmacol. 1993;16 Suppl 3:S19-31.
• [48] Effects of 1alpha,25 dihydroxyvitamin D3 and testosterone on miRNA and mRNA expression in LNCaP cells. Mol Cancer. 2011 May 18;10:58.
• [49] Large-scale in silico and microarray-based identification of direct 1,25-dihydroxyvitamin D3 target genes. Mol Endocrinol. 2005 Nov;19(11):2685-95.
• [50] Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification. Toxicol Sci. 2010 May;115(1):66-79.
• [51] Human embryonic stem cell-derived test systems for developmental neurotoxicity: a transcriptomics approach. Arch Toxicol. 2013 Jan;87(1):123-43.
• [52] Quantitative proteomic analysis of HepG2 cells treated with quercetin suggests IQGAP1 involved in quercetin-induced regulation of cell proliferation and migration. OMICS. 2009 Apr;13(2):93-103. doi: 10.1089/omi.2008.0075.
• [53] Transcriptional and Metabolic Dissection of ATRA-Induced Granulocytic Differentiation in NB4 Acute Promyelocytic Leukemia Cells. Cells. 2020 Nov 5;9(11):2423. doi: 10.3390/cells9112423.
• [54] Stem cell transcriptome responses and corresponding biomarkers that indicate the transition from adaptive responses to cytotoxicity. Chem Res Toxicol. 2017 Apr 17;30(4):905-922.
• [55] Identification of mechanisms of action of bisphenol a-induced human preadipocyte differentiation by transcriptional profiling. Obesity (Silver Spring). 2014 Nov;22(11):2333-43.
• [56] Physiological and toxicological transcriptome changes in HepG2 cells exposed to copper. Physiol Genomics. 2009 Aug 7;38(3):386-401.
• [57] Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016 Sep 6;258:227-236.
• [58] Global gene expression analysis reveals differences in cellular responses to hydroxyl- and superoxide anion radical-induced oxidative stress in caco-2 cells. Toxicol Sci. 2010 Apr;114(2):193-203. doi: 10.1093/toxsci/kfp309. Epub 2009 Dec 31.
• [59] High-throughput ectopic expression screen for tamoxifen resistance identifies an atypical kinase that blocks autophagy. Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2058-63.
• [60] Bringing in vitro analysis closer to in vivo: studying doxorubicin toxicity and associated mechanisms in 3D human microtissues with PBPK-based dose modelling. Toxicol Lett. 2018 Sep 15;294:184-192.
• [61] Unique signatures of stress-induced senescent human astrocytes. Exp Neurol. 2020 Dec;334:113466. doi: 10.1016/j.expneurol.2020.113466. Epub 2020 Sep 17.
• [62] Utilization of CDKN1A/p21 gene for class discrimination of DNA damage-induced clastogenicity. Toxicology. 2014 Jan 6;315:8-16. doi: 10.1016/j.tox.2013.10.009. Epub 2013 Nov 6.
• [63] Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system. Toxicol In Vitro. 2017 Mar;39:93-103.
• [64] Chronic occupational exposure to arsenic induces carcinogenic gene signaling networks and neoplastic transformation in human lung epithelial cells. Toxicol Appl Pharmacol. 2012 Jun 1;261(2):204-16.
• [65] Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells. Toxicology. 2017 Dec 1;392:11-21.
• [66] Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. Toxicology. 2018 Jan 15;393:160-170.
• [67] Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium. Mol Hum Reprod. 2007 Sep;13(9):641-54.
• [68] Temozolomide induces activation of Wnt/-catenin signaling in glioma cells via PI3K/Akt pathway: implications in glioma therapy. Cell Biol Toxicol. 2020 Jun;36(3):273-278. doi: 10.1007/s10565-019-09502-7. Epub 2019 Nov 22.
• [69] Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells. Toxicol Sci. 2023 Feb 17;191(2):227-238. doi: 10.1093/toxsci/kfac131.
• [70] Functional gene expression profile underlying methotrexate-induced senescence in human colon cancer cells. Tumour Biol. 2011 Oct;32(5):965-76.
• [71] Comparison of phenotypic and transcriptomic effects of false-positive genotoxins, true genotoxins and non-genotoxins using HepG2 cells. Mutagenesis. 2011 Sep;26(5):593-604.
• [72] Effects of ciglitazone and troglitazone on the proliferation of human stomach cancer cells. World J Gastroenterol. 2009 Jan 21;15(3):310-20.
• [73] Retinoid-induced epidermal hyperplasia is mediated by epidermal growth factor receptor activation via specific induction of its ligands heparin-binding EGF and amphiregulin in human skin in vivo. J Invest Dermatol. 2006 Apr;126(4):732-9. doi: 10.1038/sj.jid.5700202.
• [74] Evaluation of drug transporters' significance for multidrug resistance in head and neck squamous cell carcinoma. Head Neck. 2011 Jul;33(7):959-68. doi: 10.1002/hed.21559. Epub 2010 Aug 24.
• [75] Gene expression profiling of leukemia T-cells resistant to methotrexate and 7-hydroxymethotrexate reveals alterations that preserve intracellular levels of folate and nucleotide biosynthesis. Biochem Pharmacol. 2009 Apr 15;77(8):1410-7.
• [76] Drug sensitivity and drug resistance profiles of human intrahepatic cholangiocarcinoma cell lines. World J Gastroenterol. 2005 May 14;11(18):2748-53. doi: 10.3748/wjg.v11.i18.2748.
• [77] Adaptive homeostasis of the vitamin D-vitamin D nuclear receptor axis in 8-methoxypsoralen-induced hepatotoxicity. Toxicol Appl Pharmacol. 2019 Jan 1;362:150-158. doi: 10.1016/j.taap.2018.11.002. Epub 2018 Nov 10.
• [78] Cannabidiol induces antioxidant pathways in keratinocytes by targeting BACH1. Redox Biol. 2020 Jan;28:101321. doi: 10.1016/j.redox.2019.101321. Epub 2019 Sep 5.
• [79] Estrogen regulation in human breast cancer cells of new downstream gene targets involved in estrogen metabolism, cell proliferation and cell transformation. J Mol Endocrinol. 2004 Apr;32(2):397-414.
• [80] Differential regulation of the human MRP2 and MRP3 gene expression by glucocorticoids. J Steroid Biochem Mol Biol. 2005 Aug;96(3-4):229-34. doi: 10.1016/j.jsbmb.2005.03.004.
• [81] Induction of multidrug resistance proteins MRP1 and MRP3 and gamma-glutamylcysteine synthetase gene expression by nonsteroidal anti-inflammatory drugs in human colon cancer cells. Biochem Biophys Res Commun. 2002 Feb 8;290(5):1427-33. doi: 10.1006/bbrc.2002.6367.
• [82] Activation of nuclear factor-kappa B pathway by simvastatin and RhoA silencing increases doxorubicin cytotoxicity in human colon cancer HT29 cells. Mol Pharmacol. 2008 Aug;74(2):476-84.
• [83] Methotrexate normalizes up-regulated folate pathway genes in rheumatoid arthritis. Arthritis Rheum. 2013 Nov;65(11):2791-802.
• [84] Activation of beta-catenin signalling by GSK-3 inhibition increases p-glycoprotein expression in brain endothelial cells. J Neurochem. 2008 Aug;106(4):1855-65. doi: 10.1111/j.1471-4159.2008.05537.x. Epub 2008 Jul 4.
• [85] ATP binding cassette multidrug transporters limit the anti-HIV activity of zidovudine and indinavir in infected human macrophages. Antivir Ther. 2004 Aug;9(4):519-28.
• [86] Selenium-dependent and -independent transport of arsenic by the human multidrug resistance protein 2 (MRP2/ABCC2): implications for the mutual detoxification of arsenic and selenium. Carcinogenesis. 2010 Aug;31(8):1450-5. doi: 10.1093/carcin/bgq125. Epub 2010 Jun 27.
• [87] Hematopoietic stem cell differentiation affects expression and function of MRP4 (ABCC4), a transport protein for signaling molecules and drugs. Int J Cancer. 2009 May 15;124(10):2303-11. doi: 10.1002/ijc.24207.
• [88] Prolonged use of aspirin alters human and rat intestinal cells and thereby limits the absorption of clopidogrel. Clin Pharmacol Ther. 2011 Oct;90(4):612-9. doi: 10.1038/clpt.2011.163. Epub 2011 Sep 7.
• [89] Quantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment. J Cell Physiol. 2021 Apr;236(4):2959-2975. doi: 10.1002/jcp.30055. Epub 2020 Sep 22.
• [90] Gene expression after treatment with hydrogen peroxide, menadione, or t-butyl hydroperoxide in breast cancer cells. Cancer Res. 2002 Nov 1;62(21):6246-54.
• [91] Phenotypic characterization of retinoic acid differentiated SH-SY5Y cells by transcriptional profiling. PLoS One. 2013 May 28;8(5):e63862.
• [92] Transcriptomics hit the target: monitoring of ligand-activated and stress response pathways for chemical testing. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):7-18.
• [93] Keratinocyte gene expression profiles discriminate sensitizing and irritating compounds. Toxicol Sci. 2010 Sep;117(1):81-9.
• [94] Estrogen-mediated inactivation of FOXO3a by the G protein-coupled estrogen receptor GPER. BMC Cancer. 2015 Oct 15;15:702. doi: 10.1186/s12885-015-1699-6.
• [95] Differential expression of FOXO1 and FOXO3a confers resistance to oxidative cell death upon endometrial decidualization. Mol Endocrinol. 2006 Oct;20(10):2444-55. doi: 10.1210/me.2006-0118. Epub 2006 May 18.
• [96] Quercetin and Its Fermented Extract as a Potential Inhibitor of Bisphenol A-Exposed HT-29 Colon Cancer Cells' Viability. Int J Mol Sci. 2023 Mar 15;24(6):5604. doi: 10.3390/ijms24065604.
• [97] Retinoic acid receptor alpha amplifications and retinoic acid sensitivity in breast cancers. Clin Breast Cancer. 2013 Oct;13(5):401-8.
• [98] An in vitro study on anti-carcinogenic effect of remdesivir in human ovarian cancer cells via generation of reactive oxygen species. Hum Exp Toxicol. 2022 Jan-Dec;41:9603271221089257. doi: 10.1177/09603271221089257.
• [99] Motexafin gadolinium and zinc induce oxidative stress responses and apoptosis in B-cell lymphoma lines. Cancer Res. 2005 Dec 15;65(24):11676-88.
• [100] Nuclear and Mitochondrial DNA Methylation Patterns Induced by Valproic Acid in Human Hepatocytes. Chem Res Toxicol. 2017 Oct 16;30(10):1847-1854. doi: 10.1021/acs.chemrestox.7b00171. Epub 2017 Sep 13.
• [101] Analysis of the transcriptional regulation of cancer-related genes by aberrant DNA methylation of the cis-regulation sites in the promoter region during hepatocyte carcinogenesis caused by arsenic. Oncotarget. 2015 Aug 28;6(25):21493-506. doi: 10.18632/oncotarget.4085.
• [102] Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans. Arch Toxicol. 2018 Feb;92(2):845-858.
• [103] Reproducible chemical-induced changes in gene expression profiles in human hepatoma HepaRG cells under various experimental conditions. Toxicol In Vitro. 2009 Apr;23(3):466-75. doi: 10.1016/j.tiv.2008.12.018. Epub 2008 Dec 30.
• [104] Ethyl carbamate induces cell death through its effects on multiple metabolic pathways. Chem Biol Interact. 2017 Nov 1;277:21-32.
• [105] Microarray analyses in dendritic cells reveal potential biomarkers for chemical-induced skin sensitization. Mol Immunol. 2007 May;44(12):3222-33.
• [106] Integrative "-Omics" analysis in primary human hepatocytes unravels persistent mechanisms of cyclosporine A-induced cholestasis. Chem Res Toxicol. 2016 Dec 19;29(12):2164-2174.
• [107] Drug-induced endoplasmic reticulum and oxidative stress responses independently sensitize toward TNF-mediated hepatotoxicity. Toxicol Sci. 2014 Jul;140(1):144-59. doi: 10.1093/toxsci/kfu072. Epub 2014 Apr 20.
• [108] Prenatal arsenic exposure and the epigenome: identifying sites of 5-methylcytosine alterations that predict functional changes in gene expression in newborn cord blood and subsequent birth outcomes. Toxicol Sci. 2015 Jan;143(1):97-106. doi: 10.1093/toxsci/kfu210. Epub 2014 Oct 10.
• [109] Pregnancy exposure to synthetic phenols and placental DNA methylation - An epigenome-wide association study in male infants from the EDEN cohort. Environ Pollut. 2021 Dec 1;290:118024. doi: 10.1016/j.envpol.2021.118024. Epub 2021 Aug 21.
• [110] Screening of a chemical library reveals novel PXR-activating pharmacologic compounds. Toxicol Lett. 2015 Jan 5;232(1):193-202. doi: 10.1016/j.toxlet.2014.10.009. Epub 2014 Oct 16.
• [111] Induction of PXR-mediated metabolism by beta-carotene. Biochim Biophys Acta. 2005 May 30;1740(2):162-9. doi: 10.1016/j.bbadis.2004.11.013. Epub 2004 Dec 8.
• [112] Lignans, bacteriocides and organochlorine compounds activate the human pregnane X receptor (PXR). Toxicol Appl Pharmacol. 2005 Dec 1;209(2):123-33. doi: 10.1016/j.taap.2005.03.015.
• [113] Identification and validation of novel human pregnane X receptor activators among prescribed drugs via ligand-based virtual screening. Drug Metab Dispos. 2011 Feb;39(2):337-44. doi: 10.1124/dmd.110.035808. Epub 2010 Nov 10.
• [114] Identification of HMG-CoA reductase inhibitors as activators for human, mouse and rat constitutive androstane receptor. Drug Metab Dispos. 2005 Jul;33(7):924-9.
• [115] Acetylated deoxycholic (DCA) and cholic (CA) acids are potent ligands of pregnane X (PXR) receptor. Toxicol Lett. 2017 Jan 4;265:86-96.
• [116] Temporal changes in gene expression in the skin of patients treated with isotretinoin provide insight into its mechanism of action. Dermatoendocrinol. 2009 May;1(3):177-87.
• [117] Air pollution and DNA methylation alterations in lung cancer: A systematic and comparative study. Oncotarget. 2017 Jan 3;8(1):1369-1391. doi: 10.18632/oncotarget.13622.
• [118] Effects of acute ethanol treatment on NCCIT cells and NCCIT cell-derived embryoid bodies (EBs). Toxicol In Vitro. 2010 Sep;24(6):1696-704. doi: 10.1016/j.tiv.2010.05.017. Epub 2010 May 26.
• [119] Chenodeoxycholic acid significantly impacts the expression of miRNAs and genes involved in lipid, bile acid and drug metabolism in human hepatocytes. Life Sci. 2016 Jul 1;156:47-56.
• [120] Inhibition of human carbonyl reducing enzymes by plant anthrone and anthraquinone derivatives. Chem Biol Interact. 2022 Feb 25;354:109823. doi: 10.1016/j.cbi.2022.109823. Epub 2022 Jan 21.
• [121] Comparison of transcriptome expression alterations by chronic exposure to low-dose bisphenol A in different subtypes of breast cancer cells. Toxicol Appl Pharmacol. 2019 Dec 15;385:114814. doi: 10.1016/j.taap.2019.114814. Epub 2019 Nov 9.
• [122] Hepatoprotective effect of 7-hydroxycoumarin against methyl glyoxal toxicity via activation of Nrf2. Chem Biol Interact. 2017 Oct 1;276:203-209.
• [123] Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development. Toxicol Sci. 2010 Dec; 118(2):485-500.
• [124] Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11). Toxicol Sci. 2013 Dec;136(2):328-43.
• [125] Omics-based responses induced by bosentan in human hepatoma HepaRG cell cultures. Arch Toxicol. 2018 Jun;92(6):1939-1952.
• [126] Evaluating the Role of Multidrug Resistance Protein 3 (MDR3) Inhibition in Predicting Drug-Induced Liver Injury Using 125 Pharmaceuticals. Chem Res Toxicol. 2017 May 15;30(5):1219-1229. doi: 10.1021/acs.chemrestox.7b00048. Epub 2017 May 4.
• [127] A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development. Toxicol Sci. 2013 Nov;136(1):216-41.
• [128] EGFR tyrosine kinase inhibitors activate autophagy as a cytoprotective response in human lung cancer cells. PLoS One. 2011;6(6):e18691. doi: 10.1371/journal.pone.0018691. Epub 2011 Jun 2.
• [129] Time course study of A formation and neurite outgrowth disruption in differentiated human neuroblastoma cells exposed to H2O2: protective role of autophagy. Toxicol In Vitro. 2013 Sep;27(6):1780-8. doi: 10.1016/j.tiv.2013.05.005. Epub 2013 May 29.
• [130] Multitarget effects of quercetin in leukemia. Cancer Prev Res (Phila). 2014 Dec;7(12):1240-50. doi: 10.1158/1940-6207.CAPR-13-0383. Epub 2014 Oct 7.
• [131] Arsenic trioxide induces autophagic cell death in osteosarcoma cells via the ROS-TFEB signaling pathway. Biochem Biophys Res Commun. 2018 Jan 29;496(1):167-175. doi: 10.1016/j.bbrc.2018.01.018. Epub 2018 Jan 4.
• [132] Effects of SIDT2 on the miR-25/NOX4/HuR axis and SIRT3 mRNA stability lead to ROS-mediated TNF- expression in hydroquinone-treated leukemia cells. Cell Biol Toxicol. 2023 Oct;39(5):2207-2225. doi: 10.1007/s10565-022-09705-5. Epub 2022 Mar 18.
• [133] AMPK activation induced by promethazine increases NOXA expression and Beclin-1 phosphorylation and drives autophagy-associated apoptosis in chronic myeloid leukemia. Chem Biol Interact. 2020 Jan 5;315:108888. doi: 10.1016/j.cbi.2019.108888. Epub 2019 Nov 2.
• [134] Endoplasmic reticulum stress contributes to autophagy and apoptosis in cantharidin-induced nephrotoxicity. Food Chem Toxicol. 2022 May;163:112986. doi: 10.1016/j.fct.2022.112986. Epub 2022 Apr 6.
• [135] Assessment of mitochondrial toxicity by analysis of mitochondrial protein expression in mononuclear cells. Cytometry B Clin Cytom. 2009 May;76(3):181-90. doi: 10.1002/cyto.b.20458.
• [136] Examining the impact of skin lighteners in vitro. Oxid Med Cell Longev. 2013;2013:702120. doi: 10.1155/2013/702120. Epub 2013 Apr 28.
• [137] THC exposure of human iPSC neurons impacts genes associated with neuropsychiatric disorders. Transl Psychiatry. 2018 Apr 25;8(1):89. doi: 10.1038/s41398-018-0137-3.
• [138] White-to-brown metabolic conversion of human adipocytes by JAK inhibition. Nat Cell Biol. 2015 Jan;17(1):57-67. doi: 10.1038/ncb3075. Epub 2014 Dec 8.
• [139] Chloramphenicol-induced mitochondrial stress increases p21 expression and prevents cell apoptosis through a p21-dependent pathway. J Biol Chem. 2005 Jul 15;280(28):26193-9. doi: 10.1074/jbc.M501371200. Epub 2005 May 19.
• [140] PPARgama activation rescues mitochondrial function from inhibition of complex I and loss of PINK1. Exp Neurol. 2014 Mar;253:16-27.
• [141] Essential role of cell cycle regulatory genes p21 and p27 expression in inhibition of breast cancer cells by arsenic trioxide. Med Oncol. 2011 Dec;28(4):1225-54.
• [142] Cannabidiol Activates Neuronal Precursor Genes in Human Gingival Mesenchymal Stromal Cells. J Cell Biochem. 2017 Jun;118(6):1531-1546. doi: 10.1002/jcb.25815. Epub 2016 Dec 29.
• [143] Selection of drugs to test the specificity of the Tg.AC assay by screening for induction of the gadd153 promoter in vitro. Toxicol Sci. 2003 Aug;74(2):260-70. doi: 10.1093/toxsci/kfg113. Epub 2003 May 2.
• [144] Sertraline induces endoplasmic reticulum stress in hepatic cells. Toxicology. 2014 Aug 1;322:78-88. doi: 10.1016/j.tox.2014.05.007. Epub 2014 May 24.
• [145] Microarray analysis of H2O2-, HNE-, or tBH-treated ARPE-19 cells. Free Radic Biol Med. 2002 Nov 15;33(10):1419-32.
• [146] Methotrexate induces production of IL-1 and IL-6 in the monocytic cell line U937. Arthritis Res Ther. 2014 Jan 20;16(1):R17. doi: 10.1186/ar4444.
• [147] Simvastatin inhibits NOR-1 expression induced by hyperlipemia by interfering with CREB activation. Cardiovasc Res. 2005 Aug 1;67(2):333-41. doi: 10.1016/j.cardiores.2005.03.016. Epub 2005 Apr 21.
• [148] The G protein-coupled receptor GPR30 mediates c-fos up-regulation by 17beta-estradiol and phytoestrogens in breast cancer cells. J Biol Chem. 2004 Jun 25;279(26):27008-16. doi: 10.1074/jbc.M403588200. Epub 2004 Apr 16.
• [149] Cannabidiol enhances cytotoxicity of anti-cancer drugs in human head and neck squamous cell carcinoma. Sci Rep. 2020 Nov 26;10(1):20622. doi: 10.1038/s41598-020-77674-y.
• [150] Oxidative Stress Alters miRNA and Gene Expression Profiles in Villous First Trimester Trophoblasts. Biomed Res Int. 2015;2015:257090. doi: 10.1155/2015/257090. Epub 2015 Aug 3.
• [151] The contribution of methotrexate exposure and host factors on transcriptional variance in human liver. Toxicol Sci. 2007 Jun;97(2):582-94.
• [152] Quercetin potentiates apoptosis by inhibiting nuclear factor-kappaB signaling in H460 lung cancer cells. Biol Pharm Bull. 2013;36(6):944-51. doi: 10.1248/bpb.b12-01004.
• [153] Increased sensitivity for troglitazone-induced cytotoxicity using a human in vitro co-culture model. Toxicol In Vitro. 2009 Oct;23(7):1387-95.
• [154] Cannabidiol Modulates the Immunophenotype and Inhibits the Activation of the Inflammasome in Human Gingival Mesenchymal Stem Cells. Front Physiol. 2016 Nov 24;7:559. doi: 10.3389/fphys.2016.00559. eCollection 2016.
• [155] ERE-independent ERalpha target genes differentially expressed in human breast tumors. Mol Cell Endocrinol. 2005 Dec 21;245(1-2):53-9. doi: 10.1016/j.mce.2005.10.003. Epub 2005 Nov 17.
• [156] Reactive metabolite of gefitinib activates inflammasomes: implications for gefitinib-induced idiosyncratic reaction. J Toxicol Sci. 2020;45(11):673-680. doi: 10.2131/jts.45.673.
• [157] Gypenosides protect retinal pigment epithelium cells from oxidative stress. Food Chem Toxicol. 2018 Feb;112:76-85.
• [158] (9)-Tetrahydrocannabinol Suppresses Monocyte-Mediated Astrocyte Production of Monocyte Chemoattractant Protein 1 and Interleukin-6 in a Toll-Like Receptor 7-Stimulated Human Coculture. J Pharmacol Exp Ther. 2019 Oct;371(1):191-201. doi: 10.1124/jpet.119.260661. Epub 2019 Aug 5.
• [159] Changes in gene expression profiles in response to selenium supplementation among individuals with arsenic-induced pre-malignant skin lesions. Toxicol Lett. 2007 Mar 8;169(2):162-76. doi: 10.1016/j.toxlet.2007.01.006. Epub 2007 Jan 19.
• [160] Profiling the immunotoxicity of chemicals based on in vitro evaluation by a combination of the Multi-ImmunoTox assay and the IL-8 Luc assay. Arch Toxicol. 2018 Jun;92(6):2043-2054. doi: 10.1007/s00204-018-2199-7. Epub 2018 Mar 29.
• [161] Spironolactone induces apoptosis in human mononuclear cells. Association between apoptosis and cytokine suppression. Apoptosis. 2006 Apr;11(4):573-9. doi: 10.1007/s10495-006-4919-3.
• [162] Morphological and molecular course of mitochondrial pathology in cultured human cells exposed long-term to Zidovudine. Environ Mol Mutagen. 2007 Apr-May;48(3-4):179-89. doi: 10.1002/em.20245.
• [163] Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 Feb 26;10(1):3450. doi: 10.1038/s41598-020-59827-1.
• [164] Integrated 'omics analysis reveals new drug-induced mitochondrial perturbations in human hepatocytes. Toxicol Lett. 2018 Jun 1;289:1-13.
• [165] Effects of BMS-986094, a Guanosine Nucleotide Analogue, on Mitochondrial DNA Synthesis and Function. Toxicol Sci. 2016 Oct;153(2):396-408. doi: 10.1093/toxsci/kfw135. Epub 2016 Jul 27.
• [166] New insights into BaP-induced toxicity: role of major metabolites in transcriptomics and contribution to hepatocarcinogenesis. Arch Toxicol. 2016 Jun;90(6):1449-58.
• [167] Endoplasmic reticulum stress impairs insulin signaling through mitochondrial damage in SH-SY5Y cells. Neurosignals. 2012;20(4):265-80.
• [168] In vitro blood brain barrier exposure to mycotoxins and carotenoids pumpkin extract alters mitochondrial gene expression and oxidative stress. Food Chem Toxicol. 2021 Jul;153:112261. doi: 10.1016/j.fct.2021.112261. Epub 2021 May 17.
• [169] Bisphenol A Exposure Changes the Transcriptomic and Proteomic Dynamics of Human Retinoblastoma Y79 Cells. Genes (Basel). 2021 Feb 11;12(2):264. doi: 10.3390/genes12020264.
• [170] Human 3D multicellular microtissues: an upgraded model for the in vitro mechanistic investigation of inflammation-associated drug toxicity. Toxicol Lett. 2019 Sep 15;312:34-44.
• [171] Transcriptome dynamics of alternative splicing events revealed early phase of apoptosis induced by methylparaben in H1299 human lung carcinoma cells. Arch Toxicol. 2020 Jan;94(1):127-140. doi: 10.1007/s00204-019-02629-w. Epub 2019 Nov 20.
• [172] Role of antioxidant systems in human androgen-independent prostate cancer cells. Prostate. 2000 May 1;43(2):144-9. doi: 10.1002/(sici)1097-0045(20000501)43:2<144::aid-pros9>3.0.co;2-h.
• [173] ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
• [174] Cytotoxic Effects of Cannabinoids on Human HT-29 Colorectal Adenocarcinoma Cells: Different Mechanisms of THC, CBD, and CB83. Int J Mol Sci. 2020 Aug 1;21(15):5533. doi: 10.3390/ijms21155533.
• [175] Selenium deficiency alters epithelial cell morphology and responses to influenza. Free Radic Biol Med. 2007 Jun 15;42(12):1826-37.
• [176] Hepatocellular peroxisomes in human alcoholic and drug-induced hepatitis: a quantitative study. Hepatology. 1991 Nov;14(5):811-7.
• [177] Antioxidant enzyme and malondialdehyde values in social phobia before and after citalopram treatment. Eur Arch Psychiatry Clin Neurosci. 2004 Aug;254(4):231-5.
• [178] The effect of statins on lipids peroxidation and activities of antioxidants enzymes in patients with dyslipidemia. Przegl Lek. 2006;63(9):738-42.
• [179] Neuroprotective effects of glucomoringin-isothiocyanate against H(2)O(2)-Induced cytotoxicity in neuroblastoma (SH-SY5Y) cells. Neurotoxicology. 2019 Dec;75:89-104. doi: 10.1016/j.neuro.2019.09.008. Epub 2019 Sep 12.
• [180] Antirheumatic drug response signatures in human chondrocytes: potential molecular targets to stimulate cartilage regeneration. Arthritis Res Ther. 2009;11(1):R15.
• [181] P450 3A-catalyzed O-dealkylation of lapatinib induces mitochondrial stress and activates Nrf2. Chem Res Toxicol. 2016 May 16;29(5):784-96.
• [182] Epinephrine upregulates superoxide dismutase in human coronary artery endothelial cells. Free Radic Biol Med. 2001 Jan 15;30(2):148-53.
• [183] Cissus quadrangularis ethanol extract upregulates superoxide dismutase, glutathione peroxidase and endothelial nitric oxide synthase expression in hydrogen peroxide-injured human ECV304 cells. J Ethnopharmacol. 2012 Sep 28;143(2):664-72.
• [184] Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain. Pain. 2007 Mar;128(1-2):136-47.
• [185] Manganese superoxide dismutase is a promising target for enhancing chemosensitivity of basal-like breast carcinoma. Antioxid Redox Signal. 2014 May 20;20(15):2326-46. doi: 10.1089/ars.2013.5295. Epub 2013 Nov 14.
• [186] Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4050-61.
• [187] Cytochrome P450 1A1/2 induction by antiparasitic drugs: dose-dependent increase in ethoxyresorufin O-deethylase activity and mRNA caused by quinine, primaquine and albendazole in HepG2 cells. Eur J Clin Pharmacol. 2002 Nov;58(8):537-42.
• [188] Association of CYP1A1 and CYP1B1 inhibition in in vitro assays with drug-induced liver injury. J Toxicol Sci. 2021;46(4):167-176. doi: 10.2131/jts.46.167.
• [189] Anti-androgenic effect of 6-formylindolo[3,2-b]carbazole (FICZ) in LNCaP cells is mediated by the aryl hydrocarbon-androgen receptors cross-talk. Steroids. 2020 Jan;153:108508. doi: 10.1016/j.steroids.2019.108508. Epub 2019 Oct 3.
• [190] Pharmacologic profiling of human and rat cytochrome P450 1A1 and 1A2 induction and competition. Arch Toxicol. 2008 Dec;82(12):909-21.
• [191] Effect of CYP1A1 gene polymorphisms on estrogen metabolism and bone density. J Bone Miner Res. 2005 Feb;20(2):232-9. doi: 10.1359/JBMR.041110. Epub 2004 Nov 16.
• [192] Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase. Cancer Res. 1999 Feb 1;59(3):607-14.
• [193] Gene expression changes in human small airway epithelial cells exposed to Delta9-tetrahydrocannabinol. Toxicol Lett. 2005 Aug 14;158(2):95-107.
• [194] The metallohormone cadmium modulates AhR-associated gene expression in the small intestine of rats similar to ethinyl-estradiol. Arch Toxicol. 2013 Apr;87(4):633-43.
• [195] Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites. Gastroenterology. 2004 Nov;127(5):1436-45.
• [196] Decrease of plasminogen activator inhibitor-1 may contribute to the anti-invasive action of cannabidiol on human lung cancer cells. Pharm Res. 2010 Oct;27(10):2162-74. doi: 10.1007/s11095-010-0219-2. Epub 2010 Jul 29.
• [197] Effect of spironolactone on impaired fibrinolysis of hypertensive patients. Kidney Blood Press Res. 2002;25(4):260-4. doi: 10.1159/000066348.
• [198] Association of cell cycle arrest with anticancer drug-induced epithelial-mesenchymal transition in alveolar epithelial cells. Toxicology. 2019 Aug 1;424:152231. doi: 10.1016/j.tox.2019.06.002. Epub 2019 Jun 4.
• [199] Simvastatin inhibits tissue factor and plasminogen activator inhibitor-1 secretion by peripheral blood mononuclear cells in patients with primary nephrotic syndrome. Eur J Med Res. 2007 May 29;12(5):216-21.
• [200] Polyphenols downregulate PAI-1 gene expression in cultured human coronary artery endothelial cells: molecular contributor to cardiovascular protection. Thromb Res. 2007;121(1):59-65. doi: 10.1016/j.thromres.2007.02.001. Epub 2007 Mar 26.
• [201] Troglitazone reduces plasminogen activator inhibitor-1 expression and secretion in cultured human adipocytes. Diabetologia. 2000 Mar;43(3):377-83. doi: 10.1007/s001250050057.
• [202] Arsenic trioxide induces different gene expression profiles of genes related to growth and apoptosis in glioma cells dependent on the p53 status. Mol Biol Rep. 2008 Sep;35(3):421-9.
• [203] High-dose mitoxantrone induces programmed cell death or apoptosis in human myeloid leukemia cells. Blood. 1993 Nov 15;82(10):3133-40.
• [204] Gene expression data from acetaminophen-induced toxicity in human hepatic in vitro systems and clinical liver samples. Data Brief. 2016 Mar 26;7:1052-1057. doi: 10.1016/j.dib.2016.03.069. eCollection 2016 Jun.
• [205] Inhibition of autophagic flux differently modulates cannabidiol-induced death in 2D and 3D glioblastoma cell cultures. Sci Rep. 2020 Feb 14;10(1):2687. doi: 10.1038/s41598-020-59468-4.
• [206] Nitrogen mustard prevents transport of Fra-1 into the nucleus to promote c-Fos- and FosB-dependent IL-8 induction in injured mouse epidermis. Toxicol Lett. 2020 Feb 1;319:256-263. doi: 10.1016/j.toxlet.2019.10.006. Epub 2019 Oct 19.
• [207] Gene expression profiles with activation of the estrogen receptor alpha-selective estrogen receptor modulator complex in breast cancer cells expressing wild-type estrogen receptor. Cancer Res. 2002 Aug 1;62(15):4419-26.
• [208] Oxidative stress modulates theophylline effects on steroid responsiveness. Biochem Biophys Res Commun. 2008 Dec 19;377(3):797-802.
• [209] Nocodazole-induced p53-dependent c-Jun N-terminal kinase activation reduces apoptosis in human colon carcinoma HCT116 cells. J Biol Chem. 2002 Nov 15;277(46):43648-58. doi: 10.1074/jbc.M203214200. Epub 2002 Sep 6.
• [210] [Regulation mechanism of autophagy-related protein LC3 by c-Jun in methotrexate resistant human choriocarcinoma JEG-3 cells]. Zhonghua Fu Chan Ke Za Zhi. 2014 Jul;49(7):531-5.
• [211] Transcriptional profiling of genes induced in the livers of patients treated with carbamazepine. Clin Pharmacol Ther. 2006 Nov;80(5):440-456.
• [212] Characterization of primary human hepatocytes, HepG2 cells, and HepaRG cells at the mRNA level and CYP activity in response to inducers and their predictivity for the detection of human hepatotoxins. Cell Biol Toxicol. 2012 Apr;28(2):69-87.
• [213] Classification of heavy-metal toxicity by human DNA microarray analysis. Environ Sci Technol. 2007 May 15;41(10):3769-74.
• [214] Sp1 and Sp3 transcription factors regulate the basal expression of human microsomal epoxide hydrolase (EPHX1) through interaction with the E1b far upstream promoter. Gene. 2014 Feb 15;536(1):135-44. doi: 10.1016/j.gene.2013.11.053. Epub 2013 Dec 4.
• [215] Dasatinib reverses cancer-associated fibroblasts (CAFs) from primary lung carcinomas to a phenotype comparable to that of normal fibroblasts. Mol Cancer. 2010 Jun 27;9:168.
• [216] Inhibition of glutathione S-transferases by antimalarial drugs possible implications for circumventing anticancer drug resistance. Int J Cancer. 2002 Feb 10;97(5):700-5.
• [217] Human glutathione S-transferase A (GSTA) family genes are regulated by steroidogenic factor 1 (SF-1) and are involved in steroidogenesis. FASEB J. 2013 Aug;27(8):3198-208. doi: 10.1096/fj.12-222745. Epub 2013 May 6.
• [218] Polymorphisms of drug-metabolizing enzymes (GST, CYP2B6 and CYP3A) affect the pharmacokinetics of thiotepa and tepa. Br J Clin Pharmacol. 2009 Jan;67(1):50-60. doi: 10.1111/j.1365-2125.2008.03321.x. Epub 2008 Nov 17.
• [219] Effects of phenytoin on glutathione status and oxidative stress biomarker gene mRNA levels in cultured precision human liver slices. Toxicol Sci. 2001 Jan;59(1):118-26.
• [220] Acetaminophen-induced hepatocyte injury: C2-ceramide and oltipraz intervention, hepatocyte nuclear factor 1 and glutathione S-transferase A1 changes. J Appl Toxicol. 2019 Dec;39(12):1640-1650. doi: 10.1002/jat.3881. Epub 2019 Aug 6.
• [221] Antineoplastic drug sensitivity of human MCF-7 breast cancer cells stably transfected with a human alpha class glutathione S-transferase gene. Cancer Res. 1991 Jan 15;51(2):587-94.
• [222] Establishment of cisplatin-resistant ovarian yolk sac tumor cells and investigation of the mechanism of cisplatin resistance using this cell line. Gynecol Obstet Invest. 2011;71(2):104-11. doi: 10.1159/000320744. Epub 2010 Dec 9.
• [223] Overexpression of glutathione S-transferase A1-1 in ECV 304 cells protects against busulfan mediated G2-arrest and induces tissue factor expression. Br J Pharmacol. 2002 Dec;137(7):1100-6. doi: 10.1038/sj.bjp.0704972.
• [224] Global molecular effects of tocilizumab therapy in rheumatoid arthritis synovium. Arthritis Rheumatol. 2014 Jan;66(1):15-23.
• [225] ROS-dependent DNA damage contributes to crizotinib-induced hepatotoxicity via the apoptotic pathway. Toxicol Appl Pharmacol. 2019 Nov 15;383:114768. doi: 10.1016/j.taap.2019.114768. Epub 2019 Oct 19.
• [226] Antitumor action of the MET tyrosine kinase inhibitor crizotinib (PF-02341066) in gastric cancer positive for MET amplification. Mol Cancer Ther. 2012 Jul;11(7):1557-64. doi: 10.1158/1535-7163.MCT-11-0934. Epub 2012 Jun 22.
• [227] All-trans retinoic acid inhibits the cell proliferation but enhances the cell invasion through up-regulation of c-met in pancreatic cancer cells. Cancer Lett. 2005 Jun 28;224(2):303-10. doi: 10.1016/j.canlet.2004.10.016. Epub 2004 Dec 8.
• [228] Response to fluoxetine and serotonin 1A receptor (C-1019G) polymorphism in Taiwan Chinese major depressive disorder. Pharmacogenomics J. 2006 Jan-Feb;6(1):27-33. doi: 10.1038/sj.tpj.6500340.
• [229] Serotonin 1A receptor gene is associated with Japanese methamphetamine-induced psychosis patients. Neuropharmacology. 2010 Feb;58(2):452-6. doi: 10.1016/j.neuropharm.2009.09.006. Epub 2009 Sep 10.
• [230] Serotonin-1A receptor gene polymorphism and the ability of antipsychotic drugs to improve attention in schizophrenia. Adv Ther. 2010 May;27(5):307-13. doi: 10.1007/s12325-010-0035-4. Epub 2010 Jun 8.
• [231] Mechanisms of regulation of agonist efficacy at the 5-HT(1A) receptor by phospholipid-derived signaling components. J Pharmacol Exp Ther. 2001 Jun;297(3):1025-35.
• [232] 5-Hydroxytryptamine1A receptor occupancy by novel full antagonist 2-[4-[4-(7-chloro-2,3-dihydro-1,4-benzdioxyn-5-yl)-1-piperazinyl]butyl]-1,2-benzisothiazol-3-(2H)-one-1,1-dioxide: a[11C][O-methyl-3H]-N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide trihydrochloride (WAY-100635) positron emission tomography study in humans. J Pharmacol Exp Ther. 2002 Jun;301(3):1144-50.
• [233] MS4A3-HSP27 target pathway reveals potential for haematopoietic disorder treatment in alimentary toxic aleukia. Cell Biol Toxicol. 2023 Feb;39(1):201-216. doi: 10.1007/s10565-021-09639-4. Epub 2021 Sep 28.
• [234] Enhanced production of nitric oxide by bone marrow cells and increased sensitivity to macrophage colony-stimulating factor (CSF) and granulocyte-macrophage CSF after benzene treatment of mice. Blood. 1994 Jun 1;83(11):3255-63.
• [235] Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 4;101(5):306-20.
• [236] Alcohol and Cannabinoids Differentially Affect HIV Infection and Function of Human Monocyte-Derived Dendritic Cells (MDDC). Front Microbiol. 2015 Dec 22;6:1452. doi: 10.3389/fmicb.2015.01452. eCollection 2015.
• [237] Monomeric and oligomeric flavanols maintain the endogenous glucocorticoid response in human macrophages in pro-oxidant conditions in vitro. Chem Biol Interact. 2018 Aug 1;291:237-244.
• [238] Nicotine up-regulates IL-8 expression in human gingival epithelial cells following stimulation with IL-1 or P. gingivalis lipopolysaccharide via nicotinic acetylcholine receptor signalling. Arch Oral Biol. 2012 May;57(5):483-90. doi: 10.1016/j.archoralbio.2011.10.007. Epub 2011 Nov 25.
• [239] Ca(2+) Signaling and IL-8 Secretion in Human Testicular Peritubular Cells Involve the Cation Channel TRPV2. Int J Mol Sci. 2018 Sep 19;19(9):2829. doi: 10.3390/ijms19092829.
• [240] Calcium pantothenate modulates gene expression in proliferating human dermal fibroblasts. Exp Dermatol. 2009 Nov;18(11):969-78. doi: 10.1111/j.1600-0625.2009.00884.x. Epub 2009 Apr 8.
• [241] Nitric oxide synthase inhibitors attenuate ozone-induced airway inflammation in guinea pigs. Possible role of interleukin-8. Am J Respir Crit Care Med. 2000 Jan;161(1):249-56. doi: 10.1164/ajrccm.161.1.9804096.
• [242] Cannabidiol Modulates the Expression of Alzheimer's Disease-Related Genes in Mesenchymal Stem Cells. Int J Mol Sci. 2016 Dec 23;18(1):26. doi: 10.3390/ijms18010026.
• [243] Drug-induced hepatic steatosis in absence of severe mitochondrial dysfunction in HepaRG cells: proof of multiple mechanism-based toxicity. Cell Biol Toxicol. 2021 Apr;37(2):151-175. doi: 10.1007/s10565-020-09537-1. Epub 2020 Jun 14.
• [244] K-RAS transformation in prostate epithelial cell overcomes H2O2-induced apoptosis via upregulation of gamma-glutamyltransferase-2. Toxicol In Vitro. 2012 Apr;26(3):429-34. doi: 10.1016/j.tiv.2012.01.013. Epub 2012 Jan 17.
• [245] Consequences of the natural retinoid/retinoid X receptor ligands action in human breast cancer MDA-MB-231 cell line: Focus on functional proteomics. Toxicol Lett. 2017 Nov 5;281:26-34. doi: 10.1016/j.toxlet.2017.09.001. Epub 2017 Sep 5.
• [246] High-content imaging-based BAC-GFP toxicity pathway reporters to assess chemical adversity liabilities. Arch Toxicol. 2017 Mar;91(3):1367-1383. doi: 10.1007/s00204-016-1781-0. Epub 2016 Jun 29.
• [247] Enhanced GRP78 protein expression via the IRE1/ASK1/p38 MAPK pathway during As(2)O(3)-induced endoplasmic reticulum stress in BEAS-2B cells. Toxicology. 2021 Oct;462:152962. doi: 10.1016/j.tox.2021.152962. Epub 2021 Sep 21.
• [248] [Simvastatin-induced apoptosis of K562 cells is mediated by endoplasmic reticulum stress]. Yao Xue Xue Bao. 2008 Apr;43(4):371-7.
• [249] Chronic oxycodone induces integrated stress response in rat brain. BMC Neurosci. 2015 Sep 16;16:58. doi: 10.1186/s12868-015-0197-8.
• [250] Involvement of the activation of Nrf2/HO-1, p38 MAPK signaling pathways and endoplasmic reticulum stress in furazolidone induced cytotoxicity and S phase arrest in human hepatocyte L02 cells: modulation of curcumin. Toxicol Mech Methods. 2017 Mar;27(3):165-172. doi: 10.1080/15376516.2016.1273424. Epub 2017 Jan 8.
• [251] Arsenite and cadmium promote the development of mammary tumors. Carcinogenesis. 2020 Jul 14;41(7):1005-1014. doi: 10.1093/carcin/bgz176.
• [252] Integrated assessment by multiple gene expression analysis of quercetin bioactivity on anticancer-related mechanisms in colon cancer cells in vitro. Eur J Nutr. 2005 Mar;44(3):143-56. doi: 10.1007/s00394-004-0503-1. Epub 2004 Apr 30.
• [253] Characterization of formaldehyde's genotoxic mode of action by gene expression analysis in TK6 cells. Arch Toxicol. 2013 Nov;87(11):1999-2012.
• [254] Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity. Arch Toxicol. 2018 Jan;92(1):469-485.
• [255] The proapoptotic effect of zoledronic acid is independent of either the bone microenvironment or the intrinsic resistance to bortezomib of myeloma cells and is enhanced by the combination with arsenic trioxide. Exp Hematol. 2011 Jan;39(1):55-65.
• [256] Minimal peroxide exposure of neuronal cells induces multifaceted adaptive responses. PLoS One. 2010 Dec 17;5(12):e14352. doi: 10.1371/journal.pone.0014352.
• [257] Selenite and selenomethionine promote HL-60 cell cycle progression. J Nutr. 2002 Apr;132(4):674-9. doi: 10.1093/jn/132.4.674.
• [258] Low-expressional IGF1 mediated methimazole-induced liver developmental toxicity in fetal mice. Toxicology. 2018 Sep 1;408:70-79. doi: 10.1016/j.tox.2018.07.004. Epub 2018 Jul 7.
• [259] Ribavirin inhibits colorectal cancer growth by downregulating PRMT5 expression and H3R8me2s and H4R3me2s accumulation. Toxicol Appl Pharmacol. 2021 Mar 15;415:115450. doi: 10.1016/j.taap.2021.115450. Epub 2021 Feb 9.
• [260] Combining kallistatin gene therapy and meloxicam to treat hepatocellular carcinoma in mice. Cancer Sci. 2009 Nov;100(11):2226-33. doi: 10.1111/j.1349-7006.2009.01306.x. Epub 2009 Aug 4.
• [261] Simvastatin inactivates beta1-integrin and extracellular signal-related kinase signaling and inhibits cell proliferation in head and neck squamous cell carcinoma cells. Cancer Sci. 2007 Jun;98(6):890-9.
• [262] Epinephrine facilitates the growth of T cell lymphoma by altering cell proliferation, apoptosis, and glucose metabolism. Chem Biol Interact. 2023 Jan 5;369:110278. doi: 10.1016/j.cbi.2022.110278. Epub 2022 Nov 22.
• [263] Effects of chlorpromazine with and without UV irradiation on gene expression of HepG2 cells. Mutat Res. 2005 Aug 4;575(1-2):47-60. doi: 10.1016/j.mrfmmm.2005.03.002. Epub 2005 Apr 26.
• [264] A comprehensive analysis of Wnt/beta-catenin signaling pathway-related genes and crosstalk pathways in the treatment of As2O3 in renal cancer. Ren Fail. 2018 Nov;40(1):331-339.
• [265] Antitumor effect of aspirin in glioblastoma cells by modulation of -catenin/T-cell factor-mediated transcriptional activity. J Neurosurg. 2011 Oct;115(4):780-8. doi: 10.3171/2011.5.JNS113. Epub 2011 Jul 1.
• [266] Keratinocyte-derived IL-36gama plays a role in hydroquinone-induced chemical leukoderma through inhibition of melanogenesis in human epidermal melanocytes. Arch Toxicol. 2019 Aug;93(8):2307-2320.
• [267] JunD is involved in the antiproliferative effect of Delta9-tetrahydrocannabinol on human breast cancer cells. Oncogene. 2008 Aug 28;27(37):5033-44.
• [268] Expression profile analysis of colon cancer cells in response to sulindac or aspirin. Biochem Biophys Res Commun. 2002 Mar 29;292(2):498-512.
• [269] Effect of all-trans retinoic acid on sodium/iodide symporter expression, radioiodine uptake and gene expression profiles in a human anaplastic thyroid carcinoma cell line. Nucl Med Biol. 2006 Oct;33(7):875-82. doi: 10.1016/j.nucmedbio.2006.07.004.
• [270] Arsenic suppresses gene expression in promyelocytic leukemia cells partly through Sp1 oxidation. Blood. 2005 Jul 1;106(1):304-10.
• [271] DNA array analysis of the effects of aspirin on colon cancer cells: involvement of Rac1. Carcinogenesis. 2004 Jul;25(7):1293-8.
• [272] Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways. Food Chem Toxicol. 2021 Dec;158:112664. doi: 10.1016/j.fct.2021.112664. Epub 2021 Nov 9.
• [273] Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period. Toxicol In Vitro. 2015 Dec 25;30(1 Pt A):27-35.
• [274] Retinoic acid induces Gpx2 gene expression in MCF-7 human breast cancer cells. J Nutr. 1999 Oct;129(10):1846-54. doi: 10.1093/jn/129.10.1846.
• [275] Expression of gastrointestinal glutathione peroxidase is inversely correlated to the presence of hepatitis C virus subgenomic RNA in human liver cells. J Biol Chem. 2005 Mar 11;280(10):8831-41. doi: 10.1074/jbc.M413730200. Epub 2004 Dec 28.
• [276] Amiodarone sensitizes human glioma cells but not astrocytes to TRAIL-induced apoptosis via CHOP-mediated DR5 upregulation. Neuro Oncol. 2011 Mar;13(3):267-79. doi: 10.1093/neuonc/noq195. Epub 2011 Feb 3.
• [277] Pyrazinamide-induced hepatotoxicity is alleviated by 4-PBA via inhibition of the PERK-eIF2-ATF4-CHOP pathway. Toxicology. 2017 Mar 1;378:65-75. doi: 10.1016/j.tox.2017.01.002. Epub 2017 Jan 4.
• [278] NGBR is required to ameliorate type 2 diabetes in mice by enhancing insulin sensitivity. J Biol Chem. 2021 Jan-Jun;296:100624. doi: 10.1016/j.jbc.2021.100624. Epub 2021 Apr 2.
• [279] Rifampicin-induced injury in L02 cells is alleviated by 4-PBA via inhibition of the PERK-ATF4-CHOP pathway. Toxicol In Vitro. 2016 Oct;36:186-196. doi: 10.1016/j.tiv.2016.07.017. Epub 2016 Jul 26.
• [280] Combination of arsenic trioxide and Dasatinib: a new strategy to treat Philadelphia chromosome-positive acute lymphoblastic leukaemia. J Cell Mol Med. 2018 Mar;22(3):1614-1626.
• [281] Expression profile analysis of human peripheral blood mononuclear cells in response to aspirin. Arch Immunol Ther Exp (Warsz). 2005 Mar-Apr;53(2):151-8.
• [282] Quercetin induced cell apoptosis and altered gene expression in AGS human gastric cancer cells. Environ Toxicol. 2018 Nov;33(11):1168-1181. doi: 10.1002/tox.22623. Epub 2018 Aug 27.
• [283] Glucosamine-induced endoplasmic reticulum stress attenuates apolipoprotein B100 synthesis via PERK signaling. J Lipid Res. 2009 Sep;50(9):1814-23. doi: 10.1194/jlr.M800343-JLR200. Epub 2009 Apr 21.
• [284] Arsenic trioxide initiates ER stress responses, perturbs calcium signalling and promotes apoptosis in human lens epithelial cells. Exp Eye Res. 2007 Dec;85(6):825-35. doi: 10.1016/j.exer.2007.08.018. Epub 2007 Aug 29.
• [285] Hydroquinone-induced endoplasmic reticulum stress affects TK6 cell autophagy and apoptosis via ATF6-mTOR. Environ Toxicol. 2023 Aug;38(8):1874-1890. doi: 10.1002/tox.23814. Epub 2023 May 6.
• [286] 9-Tetrahydrocannabinol leads to endoplasmic reticulum stress and mitochondrial dysfunction in human BeWo trophoblasts. Reprod Toxicol. 2019 Aug;87:21-31. doi: 10.1016/j.reprotox.2019.04.008. Epub 2019 May 1.
• [287] Cytochrome P450 inhibition potential of new psychoactive substances of the tryptamine class. Toxicol Lett. 2016 Jan 22;241:82-94.
• [288] Transcriptional profiling suggests that Nevirapine and Ritonavir cause drug induced liver injury through distinct mechanisms in primary human hepatocytes. Chem Biol Interact. 2016 Aug 5;255:31-44.
• [289] Evaluation of gene induction of drug-metabolizing enzymes and transporters in primary culture of human hepatocytes using high-sensitivity real-time reverse transcription PCR. Yakugaku Zasshi. 2002 May;122(5):339-61.
• [290] Thalidomide increases human hepatic cytochrome P450 3A enzymes by direct activation of the pregnane X receptor. Chem Res Toxicol. 2014 Feb 17;27(2):304-308.
• [291] Human constitutive androstane receptor mediates induction of CYP2B6 gene expression by phenytoin. J Biol Chem. 2004 Jul 9;279(28):29295-301. doi: 10.1074/jbc.M400580200. Epub 2004 Apr 28.
• [292] Identification of novel agonists by high-throughput screening and molecular modelling of human constitutive androstane receptor isoform 3. Arch Toxicol. 2019 Aug;93(8):2247-2264. doi: 10.1007/s00204-019-02495-6. Epub 2019 Jul 16.
• [293] Antimalarial artemisinin drugs induce cytochrome P450 and MDR1 expression by activation of xenosensors pregnane X receptor and constitutive androstane receptor. Mol Pharmacol. 2005 Jun;67(6):1954-65.
• [294] Characterization of human cytochrome P450 induction by pesticides. Toxicology. 2012 Mar 29;294(1):17-26.
• [295] Species-specific mechanisms for cholesterol 7alpha-hydroxylase (CYP7A1) regulation by drugs and bile acids. Arch Biochem Biophys. 2005 Feb 1;434(1):75-85.
• [296] Pyrethroids: cytotoxicity and induction of CYP isoforms in human hepatocytes. Drug Metabol Drug Interact. 2008;23(3-4):211-36.
• [297] [Reversal effect of MDR1 and MDR3 gene silencing on resistance of A2780/taxol cells to paclitaxel]. Zhonghua Fu Chan Ke Za Zhi. 2007 Jun;42(6):412-6.
• [298] 8-Methoxypsoralen disrupts MDR3-mediated phospholipids efflux and bile acid homeostasis and its relevance to hepatotoxicity. Toxicology. 2017 Jul 1;386:40-48. doi: 10.1016/j.tox.2017.05.011. Epub 2017 May 24.
• [299] Species-specific toxicity of diclofenac and troglitazone in primary human and rat hepatocytes. Chem Biol Interact. 2009 Apr 15;179(1):17-24.
• [300] Human oligodendrocytes derived from embryonic stem cells: Effect of noggin on phenotypic differentiation in vitro and on myelination in vivo. Mol Cell Neurosci. 2007 Mar;34(3):310-23. doi: 10.1016/j.mcn.2006.11.008. Epub 2006 Dec 28.
• [301] 2,3,7,8-tetrachlorodibenzo-p-dioxin augments the modulation of gene expression mediated by the thyroid hormone receptor. Toxicol Appl Pharmacol. 2004 Feb 1;194(3):201-10. doi: 10.1016/j.taap.2003.09.010.
• [302] Evaluation of a human iPSC-derived BBB model for repeated dose toxicity testing with cyclosporine A as model compound. Toxicol In Vitro. 2021 Jun;73:105112. doi: 10.1016/j.tiv.2021.105112. Epub 2021 Feb 22.
• [303] The farnesoid X receptor controls gene expression in a ligand- and promoter-selective fashion. J Biol Chem. 2004 Mar 5;279(10):8856-61. doi: 10.1074/jbc.M306422200. Epub 2003 Dec 18.
• [304] The methyl transferase PRMT1 functions as co-activator of farnesoid X receptor (FXR)/9-cis retinoid X receptor and regulates transcription of FXR responsive genes. Mol Pharmacol. 2005 Aug;68(2):551-8. doi: 10.1124/mol.105.012104. Epub 2005 May 23.
• [305] Combination of retinoic acid and ursodeoxycholic acid attenuates liver injury in bile duct-ligated rats and human hepatic cells. Hepatology. 2011 Feb;53(2):548-57. doi: 10.1002/hep.24047. Epub 2010 Dec 10.
• [306] A novel bile acid-activated vitamin D receptor signaling in human hepatocytes. Mol Endocrinol. 2010 Jun;24(6):1151-64.
• [307] Darinaparsin induces a unique cellular response and is active in an arsenic trioxide-resistant myeloma cell line. Mol Cancer Ther. 2009 May;8(5):1197-206.
• [308] Inhibiting Heat Shock Proteins Can Potentiate the Cytotoxic Effect of Cannabidiol in Human Glioma Cells. Anticancer Res. 2015 Nov;35(11):5827-37.
• [309] Transcriptome-based functional classifiers for direct immunotoxicity. Arch Toxicol. 2014 Mar;88(3):673-89.
• [310] Survival of retinal pigment epithelium after exposure to prolonged oxidative injury: a detailed gene expression and cellular analysis. Invest Ophthalmol Vis Sci. 2004 Oct;45(10):3767-77.
• [311] Polyunsaturated fatty acids synergize with lipid droplet binding thalidomide analogs to induce oxidative stress in cancer cells. Lipids Health Dis. 2010 Jun 2;9:56. doi: 10.1186/1476-511X-9-56.
• [312] Repression of Kisspeptin1 weakens hydrogen peroxide-caused injury in HTR8 cells via adjusting PI3K/AKT/mTOR pathway. J Biochem Mol Toxicol. 2020 May;34(5):e22461. doi: 10.1002/jbt.22461. Epub 2020 Feb 11.
• [313] Anticarcinogenic action of quercetin by downregulation of phosphatidylinositol 3-kinase (PI3K) and protein kinase C (PKC) via induction of p53 in hepatocellular carcinoma (HepG2) cell line. Mol Biol Rep. 2015 Sep;42(9):1419-29. doi: 10.1007/s11033-015-3921-7. Epub 2015 Aug 27.
• [314] Arsenic trioxide reduces the expression of E2F1, cyclin E, and phosphorylation of PI3K signaling molecules in acute leukemia cells. Environ Toxicol. 2021 Sep;36(9):1785-1792. doi: 10.1002/tox.23299. Epub 2021 May 27.
• [315] Lunasin, a novel seed peptide, sensitizes human breast cancer MDA-MB-231 cells to aspirin-arrested cell cycle and induced apoptosis. Chem Biol Interact. 2010 Jul 30;186(2):127-34. doi: 10.1016/j.cbi.2010.04.027. Epub 2010 May 21.
• [316] The exosome-like vesicles derived from androgen exposed-prostate stromal cells promote epithelial cells proliferation and epithelial-mesenchymal transition. Toxicol Appl Pharmacol. 2021 Jan 15;411:115384. doi: 10.1016/j.taap.2020.115384. Epub 2020 Dec 25.
• [317] A systems biology understanding of the synergistic effects of arsenic sulfide and Imatinib in BCR/ABL-associated leukemia. Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3378-83.
• [318] Cantharidin suppresses gastric cancer cell migration/invasion by inhibiting the PI3K/Akt signaling pathway via CCAT1. Chem Biol Interact. 2020 Feb 1;317:108939. doi: 10.1016/j.cbi.2020.108939. Epub 2020 Jan 13.
• [319] Induction of CCAAT/enhancer-binding protein-homologous protein by cigarette smoke through the superoxide anion-triggered PERK-eIF2 pathway. Toxicology. 2011 Sep 5;287(1-3):105-12. doi: 10.1016/j.tox.2011.06.005. Epub 2011 Jun 15.
• [320] Utilization of causal reasoning of hepatic gene expression in rats to identify molecular pathways of idiosyncratic drug-induced liver injury. Toxicol Sci. 2014 Jan;137(1):234-48. doi: 10.1093/toxsci/kft232. Epub 2013 Oct 17.
• [321] Methotrexate modulates folate phenotype and inflammatory profile in EA.hy 926 cells. Eur J Pharmacol. 2014 Jun 5;732:60-7.
• [322] HMG-CoA reductase inhibition reduces monocyte CC chemokine receptor 2 expression and monocyte chemoattractant protein-1-mediated monocyte recruitment in vivo. Circulation. 2005 Mar 22;111(11):1439-47. doi: 10.1161/01.CIR.0000158484.18024.1F.
• [323] Chemokine induction by all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia: triggering the differentiation syndrome. Blood. 2009 Dec 24;114(27):5512-21. doi: 10.1182/blood-2009-02-204834. Epub 2009 Oct 14.
• [324] Comparative study of the effects of ziram and disulfiram on human monocyte-derived macrophage functions and polarization: involvement of zinc. Cell Biol Toxicol. 2021 Jun;37(3):379-400. doi: 10.1007/s10565-020-09540-6. Epub 2020 Jul 25.
• [325] Role of MCP-1 in alcohol-induced aggressiveness of colorectal cancer cells. Mol Carcinog. 2016 May;55(5):1002-11. doi: 10.1002/mc.22343. Epub 2015 May 25.
• [326] Differential regulation of CC chemokine receptors by 9-cis retinoic acid in the human mast cell line, HMC-1. Life Sci. 2006 Aug 22;79(13):1293-300. doi: 10.1016/j.lfs.2006.03.046. Epub 2006 Apr 22.
• [327] Characterization of DOK1, a candidate tumor suppressor gene, in epithelial ovarian cancer. Mol Oncol. 2011 Oct;5(5):438-53. doi: 10.1016/j.molonc.2011.07.003. Epub 2011 Jul 26.
• [328] Low doses of cisplatin induce gene alterations, cell cycle arrest, and apoptosis in human promyelocytic leukemia cells. Biomark Insights. 2016 Aug 24;11:113-21.
• [329] Pattern of expression of apoptosis and inflammatory genes in humans exposed to arsenic and/or fluoride. Sci Total Environ. 2010 Jan 15;408(4):760-7. doi: 10.1016/j.scitotenv.2009.11.016. Epub 2009 Dec 4.
• [330] Different apoptosis ratios and gene expressions in two human cell lines after sevoflurane anaesthesia. Acta Anaesthesiol Scand. 2009 Oct;53(9):1192-9. doi: 10.1111/j.1399-6576.2009.02036.x. Epub 2009 Jun 30.
• [331] [Mechanisms underlying the effect of arsenic trioxide on proliferation inhibition and apoptosis induction in myeloma cell line u266]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2007 Oct;15(5):982-5.
• [332] Lovastatin lactone elicits human lung cancer cell apoptosis via a COX-2/PPAR-dependent pathway. Oncotarget. 2016 Mar 1;7(9):10345-62. doi: 10.18632/oncotarget.7213.
• [333] Induction of apoptosis by cidofovir in human papillomavirus (HPV)-positive cells. Oncol Res. 2000;12(9-10):397-408. doi: 10.3727/096504001108747855.
• [334] Comparison of burst of reactive oxygen species and activation of caspase-3 in apoptosis of K562 and HL-60 cells induced by docetaxel. Cancer Lett. 2004 Oct 8;214(1):103-13. doi: 10.1016/j.canlet.2004.03.047.
• [335] Induction of mitochondrial manganese superoxide dismutase confers resistance to apoptosis in acute myeloblastic leukaemia cells exposed to etoposide. Br J Haematol. 2000 Mar;108(3):574-81. doi: 10.1046/j.1365-2141.2000.01852.x.
• [336] Cisplatin-enhanced sensitivity of glioblastoma multiforme U251 cells to adenovirus-delivered TRAIL in vitro. Tumour Biol. 2010 Dec;31(6):613-22. doi: 10.1007/s13277-010-0077-x. Epub 2010 Jul 11.
• [337] Insulin-like growth factor I is the key growth factor in serum that protects neuroblastoma cells from hyperosmotic-induced apoptosis. J Cell Physiol. 2000 Jan;182(1):24-32. doi: 10.1002/(SICI)1097-4652(200001)182:1<24::AID-JCP3>3.0.CO;2-6.
• [338] mRNA expression analysis of a variety of apoptosis-related genes, including the novel gene of the BCL2-family, BCL2L12, in HL-60 leukemia cells after treatment with carboplatin and doxorubicin. Biol Chem. 2004 Nov;385(11):1099-103. doi: 10.1515/BC.2004.143.
• [339] Neurokinin-1 receptor (NK1R) inhibition sensitizes APL cells to anti-tumor effect of arsenic trioxide via restriction of NF-B axis: Shedding new light on resistance to Aprepitant. Int J Biochem Cell Biol. 2018 Oct;103:105-114. doi: 10.1016/j.biocel.2018.08.010. Epub 2018 Aug 23.
• [340] Cannabidiol Effectively Promoted Cell Death in Bladder Cancer and the Improved Intravesical Adhesion Drugs Delivery Strategy Could Be Better Used for Treatment. Pharmaceutics. 2021 Sep 7;13(9):1415. doi: 10.3390/pharmaceutics13091415.
• [341] A model to identify novel targets involved in oxidative stress-induced apoptosis in human lung epithelial cells by RNA interference. Toxicol In Vitro. 2010 Feb;24(1):310-8. doi: 10.1016/j.tiv.2009.08.008. Epub 2009 Aug 23.
• [342] Nitric oxide inhibits execution of apoptosis at two distinct ATP-dependent steps upstream and downstream of mitochondrial cytochrome c release. Biochem Biophys Res Commun. 1999 Apr 29;258(1):215-21. doi: 10.1006/bbrc.1999.0491.
• [343] Palmitate increases the susceptibility of cells to drug-induced toxicity: an in vitro method to identify drugs with potential contraindications in patients with metabolic disease. Toxicol Sci. 2012 Oct;129(2):346-62. doi: 10.1093/toxsci/kfs208. Epub 2012 Jun 14.
• [344] Response rate of fibrosarcoma cells to cytotoxic drugs on the expression level correlates to the therapeutic response rate of fibrosarcomas and is mediated by regulation of apoptotic pathways. BMC Cancer. 2005 Jul 7;5:74. doi: 10.1186/1471-2407-5-74.
• [345] Simvastatin induces apoptosis and alters cytoskeleton in endometrial stromal cells. J Clin Endocrinol Metab. 2010 Jul;95(7):3453-9. doi: 10.1210/jc.2010-0072. Epub 2010 Apr 28.
• [346] The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib. Toxicol Sci. 2023 Dec 21;197(1):69-78. doi: 10.1093/toxsci/kfad099.
• [347] Lovastatin induces apoptosis of anaplastic thyroid cancer cells via inhibition of protein geranylgeranylation and de novo protein synthesis. Endocrinology. 2003 Sep;144(9):3852-9. doi: 10.1210/en.2003-0098.
• [348] Insulin-like growth factor I prevents mannitol-induced degradation of focal adhesion kinase and Akt. J Biol Chem. 2002 Jul 26;277(30):27393-400. doi: 10.1074/jbc.M201963200. Epub 2002 May 14.
• [349] Inhibition of caspase-dependent mitochondrial permeability transition protects airway epithelial cells against mustard-induced apoptosis. Apoptosis. 2006 Sep;11(9):1545-59. doi: 10.1007/s10495-006-8764-1.
• [350] Effects of gonadotrophin-releasing hormone agonists on apoptosis of granulosa cells. Ann N Y Acad Sci. 2005 May;1042:531-7. doi: 10.1196/annals.1338.065.
• [351] The effects of quercetin in cultured human RPE cells under oxidative stress and in Ccl2/Cx3cr1 double deficient mice. Exp Eye Res. 2010 Jul;91(1):15-25.
• [352] Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53. Cancer Res. 2004 May 1;64(9):3022-9. doi: 10.1158/0008-5472.can-03-1880.
• [353] Inhibiting AKT signaling pathway with cilostazol and meloxicam synergism for suppressing K562 cells in vitro. J Biochem Mol Toxicol. 2022 Nov;36(11):e23185. doi: 10.1002/jbt.23185. Epub 2022 Aug 3.
• [354] Ciprofloxacin induces apoptosis and inhibits proliferation of human colorectal carcinoma cells. Br J Cancer. 2002 Feb 1;86(3):443-8. doi: 10.1038/sj.bjc.6600079.
• [355] Colchicine-induced apoptosis in human normal liver L-02 cells by mitochondrial mediated pathways. Toxicol In Vitro. 2012 Aug;26(5):649-55. doi: 10.1016/j.tiv.2012.01.024. Epub 2012 Feb 8.
• [356] Extracellular calcium increases bisphosphonate-induced growth inhibition of breast cancer cells. Breast Cancer Res. 2008;10(1):R4. doi: 10.1186/bcr1845. Epub 2008 Jan 11.
• [357] Comparative gene expression profiling reveals partially overlapping but distinct genomic actions of different antiestrogens in human breast cancer cells. J Cell Biochem. 2006 Aug 1;98(5):1163-84.
• [358] Statin-induced Mitochondrial Priming Sensitizes Multiple Myeloma Cells to BCL2 and MCL-1 Inhibitors. Cancer Res Commun. 2023 Dec 8;3(12):2497-2509. doi: 10.1158/2767-9764.CRC-23-0350.
• [359] Efficacy of a nitrogen-containing bisphosphonate, minodronate, in conjunction with a p38 mitogen activated protein kinase inhibitor or doxorubicin against malignant bone tumor cells. Cancer Chemother Pharmacol. 2008 Jun;62(1):111-6. doi: 10.1007/s00280-007-0580-y. Epub 2007 Sep 15.
• [360] Nitrogen-containing bisphosphonates induce apoptosis of Caco-2 cells in vitro by inhibiting the mevalonate pathway: a model of bisphosphonate-induced gastrointestinal toxicity. Bone. 2001 Oct;29(4):336-43. doi: 10.1016/s8756-3282(01)00589-0.
• [361] Synergistic interaction of lovastatin and paclitaxel in human cancer cells. Mol Cancer Ther. 2001 Dec;1(2):141-9.
• [362] Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro. Toxicol In Vitro. 2015 Apr;29(3):489-501.
• [363] The neuroprotective action of the mood stabilizing drugs lithium chloride and sodium valproate is mediated through the up-regulation of the homeodomain protein Six1. Toxicol Appl Pharmacol. 2009 Feb 15;235(1):124-34.
• [364] D-Penicillamine targets metastatic melanoma cells with induction of the unfolded protein response (UPR) and Noxa (PMAIP1)-dependent mitochondrial apoptosis. Apoptosis. 2012 Oct;17(10):1079-94.
• [365] The sunless tanning agent dihydroxyacetone induces stress response gene expression and signaling in cultured human keratinocytes and reconstructed epidermis. Redox Biol. 2020 Sep;36:101594. doi: 10.1016/j.redox.2020.101594. Epub 2020 May 29.
• [366] Cytosine arabinoside induces ectoderm and inhibits mesoderm expression in human embryonic stem cells during multilineage differentiation. Br J Pharmacol. 2011 Apr;162(8):1743-56.
• [367] Transcriptome and DNA methylome dynamics during triclosan-induced cardiomyocyte differentiation toxicity. Stem Cells Int. 2018 Oct 29;2018:8608327.
• [368] Evaluation of xenobiotic N- and S-oxidation by variant flavin-containing monooxygenase 1 (FMO1) enzymes. Toxicol Sci. 2004 Apr;78(2):196-203.
• [369] A transcriptome-based classifier to identify developmental toxicants by stem cell testing: design, validation and optimization for histone deacetylase inhibitors. Arch Toxicol. 2015 Sep;89(9):1599-618.
• [370] Retinoic acid and its 4-oxo metabolites are functionally active in human skin cells in vitro. J Invest Dermatol. 2005 Jul;125(1):143-53.
• [371] Steroidogenic gene expression in H295R cells and the human adrenal gland: adrenotoxic effects of lindane in vitro. J Appl Toxicol. 2006 Nov-Dec;26(6):484-92.
• [372] Solvent effect on cDNA-expressed human sulfotransferase (SULT) activities in vitro. Drug Metab Dispos. 2003 Nov;31(11):1300-5.
• [373] Comparison of the effects of metoclopramide and domperidone on HERG channels. Pharmacology. 2005 Apr;74(1):31-6. doi: 10.1159/000083234. Epub 2005 Jan 7.
• [374] Further insights into the effect of quinidine in short QT syndrome caused by a mutation in HERG. J Cardiovasc Electrophysiol. 2005 Jan;16(1):54-8. doi: 10.1046/j.1540-8167.2005.04470.x.
• [375] Automated tight seal electrophysiology for assessing the potential hERG liability of pharmaceutical compounds. Assay Drug Dev Technol. 2004 Oct;2(5):497-506. doi: 10.1089/adt.2004.2.497.
• [376] Refining the human iPSC-cardiomyocyte arrhythmic risk assessment model. Toxicol Sci. 2013 Dec;136(2):581-94. doi: 10.1093/toxsci/kft205. Epub 2013 Sep 19.
• [377] Pharmacology of the short QT syndrome N588K-hERG K+ channel mutation: differential impact on selected class I and class III antiarrhythmic drugs. Br J Pharmacol. 2008 Nov;155(6):957-66. doi: 10.1038/bjp.2008.325. Epub 2008 Aug 25.
• [378] Comparison of HERG channel blocking effects of various beta-blockers-- implication for clinical strategy. Br J Pharmacol. 2006 Mar;147(6):642-52. doi: 10.1038/sj.bjp.0706508.
• [379] Inhibitory effects of the class III antiarrhythmic drug amiodarone on cloned HERG potassium channels. Naunyn Schmiedebergs Arch Pharmacol. 1999 Mar;359(3):212-9. doi: 10.1007/pl00005344.
• [380] Redox state dependency of HERGS631C channel pharmacology: relation to C-type inactivation. FEBS Lett. 2000 May 26;474(1):111-5. doi: 10.1016/s0014-5793(00)01586-6.
• [381] Sulindac enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human lung cancer. Mol Cancer Ther. 2005 Feb;4(2):291-304.
• [382] Differential modulation of PI3-kinase/Akt pathway during all-trans retinoic acid- and Am80-induced HL-60 cell differentiation revealed by DNA microarray analysis. Biochem Pharmacol. 2004 Dec 1;68(11):2177-86.
• [383] Evaluation of gene expression changes in human primary lung epithelial cells following 24-hr exposures to inorganic arsenic and its methylated metabolites and to arsenic trioxide. Environ Mol Mutagen. 2015 Jun;56(5):477-90. doi: 10.1002/em.21937. Epub 2015 Apr 14.
• [384] A microarray study on the effect of four hormone therapy regimens on gene transcription in whole blood from healthy postmenopausal women. Thromb Res. 2012 Jul;130(1):45-51. doi: 10.1016/j.thromres.2011.12.009. Epub 2012 Jan 2.
• [385] Transcriptional profiling of testosterone-regulated genes in the skeletal muscle of human immunodeficiency virus-infected men experiencing weight loss. J Clin Endocrinol Metab. 2007 Jul;92(7):2793-802. doi: 10.1210/jc.2006-2722. Epub 2007 Apr 17.
• [386] Ultradian cortisol pulsatility encodes a distinct, biologically important signal. PLoS One. 2011 Jan 18;6(1):e15766.
• [387] Inhibition of the erythropoietin-producing receptor EPHB4 antagonizes androgen receptor overexpression and reduces enzalutamide resistance. J Biol Chem. 2020 Apr 17;295(16):5470-5483. doi: 10.1074/jbc.RA119.011385. Epub 2020 Mar 17.
• [388] Transcriptomic Analysis of Stem Cells Treated with Moringin or Cannabidiol: Analogies and Differences in Inflammation Pathways. Int J Mol Sci. 2019 Nov 30;20(23):6039. doi: 10.3390/ijms20236039.
• [389] Antidepressant drug sertraline modulates AMPK-MTOR signaling-mediated autophagy via targeting mitochondrial VDAC1 protein. Autophagy. 2021 Oct;17(10):2783-2799. doi: 10.1080/15548627.2020.1841953. Epub 2020 Nov 9.
• [390] Autophagy Inhibition Overcomes the Antagonistic Effect Between Gefitinib and Cisplatin in Epidermal Growth Factor Receptor Mutant Non--Small-Cell Lung Cancer Cells. Clin Lung Cancer. 2015 Sep;16(5):e55-66. doi: 10.1016/j.cllc.2015.03.006. Epub 2015 Apr 2.
• [391] Harnessing autophagy to overcome mitogen-activated protein kinase kinase inhibitor-induced resistance in metastatic melanoma. Br J Dermatol. 2019 Feb;180(2):346-356. doi: 10.1111/bjd.17333. Epub 2018 Nov 25.
• [392] Systems analysis of transcriptome and proteome in retinoic acid/arsenic trioxide-induced cell differentiation/apoptosis of promyelocytic leukemia. Proc Natl Acad Sci U S A. 2005 May 24;102(21):7653-8.
• [393] Targeting of EGFR increase?anti-cancer effects of arsenic trioxide: Promising treatment for glioblastoma multiform. Eur J Pharmacol. 2018 Feb 5;820:274-285. doi: 10.1016/j.ejphar.2017.12.041. Epub 2017 Dec 20.
• [394] Aspirin and alterations in DNA repair proteins in the SW480 colorectal cancer cell line. Oncol Rep. 2010 Jul;24(1):37-46. doi: 10.3892/or_00000826.
• [395] Ouabain induces apoptotic cell death in human prostate DU 145 cancer cells through DNA damage and TRAIL pathways. Environ Toxicol. 2019 Dec;34(12):1329-1339. doi: 10.1002/tox.22834. Epub 2019 Aug 21.
• [396] An ATM- and Rad3-related (ATR) signaling pathway and a phosphorylation-acetylation cascade are involved in activation of p53/p21Waf1/Cip1 in response to 5-aza-2'-deoxycytidine treatment. J Biol Chem. 2008 Feb 1;283(5):2564-74. doi: 10.1074/jbc.M702454200. Epub 2007 Oct 31.
• [397] RIP kinase is involved in arsenic-induced apoptosis in multiple myeloma cells. Apoptosis. 2004 Sep;9(5):561-71. doi: 10.1023/B:APPT.0000038030.47068.49.
• [398] Gallic acid protects against ethanol-induced hepatocyte necroptosis via an NRF2-dependent mechanism. Toxicol In Vitro. 2019 Jun;57:226-232. doi: 10.1016/j.tiv.2019.03.008. Epub 2019 Mar 7.
• [399] Repurposing L-menthol for systems medicine and cancer therapeutics? L-menthol induces apoptosis through caspase 10 and by suppressing HSP90. OMICS. 2016 Jan;20(1):53-64.
• [400] Synergistic antiproliferative effect of arsenic trioxide combined with bortezomib in HL60 cell line and primary blasts from patients affected by myeloproliferative disorders. Cancer Genet Cytogenet. 2010 Jun;199(2):110-20. doi: 10.1016/j.cancergencyto.2010.02.010.
• [401] Time series analysis of oxidative stress response patterns in HepG2: a toxicogenomics approach. Toxicology. 2013 Apr 5;306:24-34.
• [402] Methotrexate induces apoptosis through p53/p21-dependent pathway and increases E-cadherin expression through downregulation of HDAC/EZH2. Biochem Pharmacol. 2011 Feb 15;81(4):510-7. doi: 10.1016/j.bcp.2010.11.014. Epub 2010 Nov 27.
• [403] Statin-triggered cell death in primary human lung mesenchymal cells involves p53-PUMA and release of Smac and Omi but not cytochrome c. Biochim Biophys Acta. 2010 Apr;1803(4):452-67. doi: 10.1016/j.bbamcr.2009.12.005. Epub 2010 Jan 4.
• [404] Adipogenic Effects and Gene Expression Profiling of Firemaster? 550 Components in Human Primary Preadipocytes. Environ Health Perspect. 2017 Sep 14;125(9):097013. doi: 10.1289/EHP1318.
• [405] Comparison of the gene expression profiles of monocytic versus granulocytic lineages of HL-60 leukemia cell differentiation by DNA microarray analysis. Life Sci. 2003 Aug 15;73(13):1705-19. doi: 10.1016/s0024-3205(03)00515-0.
• [406] DNA methylome-wide alterations associated with estrogen receptor-dependent effects of bisphenols in breast cancer. Clin Epigenetics. 2019 Oct 10;11(1):138. doi: 10.1186/s13148-019-0725-y.
• [407] Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes. Toxicol Appl Pharmacol. 2013 Oct 1;272(1):245-55.
• [408] Modulation of the heart's electrical properties by the anticonvulsant drug retigabine. Toxicol Appl Pharmacol. 2017 Aug 15;329:309-317. doi: 10.1016/j.taap.2017.06.018. Epub 2017 Jun 20.
• [409] Exposure to Insecticides Modifies Gene Expression and DNA Methylation in Hematopoietic Tissues In Vitro. Int J Mol Sci. 2023 Mar 26;24(7):6259. doi: 10.3390/ijms24076259.
• [410] CACNA1C gene polymorphisms, cardiovascular disease outcomes, and treatment response. Circ Cardiovasc Genet. 2009 Aug;2(4):362-70. doi: 10.1161/CIRCGENETICS.109.857839. Epub 2009 Jun 3.
• [411] Ethnic-Related Sodium Voltage-Gated Channel Subunit 5 Polymorphisms Shape the In Vitro Pharmacological Action of Amiodarone upon Na(v)1.5. Mol Pharmacol. 2021 Jun;99(6):448-459. doi: 10.1124/molpharm.120.000176. Epub 2021 Apr 6.
• [412] Flecainide test in Brugada syndrome: a reproducible but risky tool. Pacing Clin Electrophysiol. 2003 Jan;26(1P2):338-41. doi: 10.1046/j.1460-9592.2003.00045.x.
• [413] Inhibitory effects of cannabidiol on voltage-dependent sodium currents. J Biol Chem. 2018 Oct 26;293(43):16546-16558. doi: 10.1074/jbc.RA118.004929. Epub 2018 Sep 14.
• [414] Regulatory effects of non-steroidal anti-inflammatory drugs on cardiac ion channels Nav1.5 and Kv11.1. Chem Biol Interact. 2021 Apr 1;338:109425. doi: 10.1016/j.cbi.2021.109425. Epub 2021 Feb 19.
• [415] Gene Expression Regulation and Pathway Analysis After Valproic Acid and Carbamazepine Exposure in a Human Embryonic Stem Cell-Based Neurodevelopmental Toxicity Assay. Toxicol Sci. 2015 Aug;146(2):311-20. doi: 10.1093/toxsci/kfv094. Epub 2015 May 15.
• [416] Brugada syndrome ECG provoked by the selective serotonin reuptake inhibitor fluvoxamine. Europace. 2010 Feb;12(2):282-3. doi: 10.1093/europace/eup332. Epub 2009 Oct 29.
• [417] Dysregulation of retinoic acid receptor diminishes hepatocyte permissiveness to hepatitis B virus infection through modulation of sodium taurocholate cotransporting polypeptide (NTCP) expression. J Biol Chem. 2015 Feb 27;290(9):5673-84. doi: 10.1074/jbc.M114.602540. Epub 2014 Dec 30.
• [418] Differential regulation of sinusoidal and canalicular hepatic drug transporter expression by xenobiotics activating drug-sensing receptors in primary human hepatocytes. Drug Metab Dispos. 2006 Oct;34(10):1756-63. doi: 10.1124/dmd.106.010033. Epub 2006 Jul 12.
• [419] Potency of individual bile acids to regulate bile acid synthesis and transport genes in primary human hepatocyte cultures. Toxicol Sci. 2014 Oct;141(2):538-46. doi: 10.1093/toxsci/kfu151. Epub 2014 Jul 23.
• [420] Regulation of hepatic drug transporter activity and expression by organochlorine pesticides. J Biochem Mol Toxicol. 2014 Mar;28(3):119-28.
• [421] Bioactive terpenoids and flavonoids from Ginkgo biloba extract induce the expression of hepatic drug-metabolizing enzymes through pregnane X receptor, constitutive androstane receptor, and aryl hydrocarbon receptor-mediated pathways. Pharm Res. 2009 Apr;26(4):872-82.
• [422] Fetal bovine serum and human constitutive androstane receptor: evidence for activation of the SV23 splice variant by artemisinin, artemether, and arteether in a serum-free cell culture system. Toxicol Appl Pharmacol. 2014 Jun 1;277(2):221-30. doi: 10.1016/j.taap.2014.03.023. Epub 2014 Apr 12.
• [423] Constitutive androstane/active receptor is a target of retinoic acid receptor in humans. Biochem Pharmacol. 2010 Jul 1;80(1):129-35. doi: 10.1016/j.bcp.2010.02.023. Epub 2010 Mar 6.
• [424] Expression and inducibility of cytochrome P450s (CYP1A1, 2B6, 2E1, 3A4) in human cord blood CD34(+) stem cell-derived differentiating neuronal cells. Toxicol Sci. 2012 Oct;129(2):392-410.
• [425] Agonistic effects of diverse xenobiotics on the constitutive androstane receptor as detected in a recombinant yeast-cell assay. Toxicol In Vitro. 2018 Feb;46:335-349. doi: 10.1016/j.tiv.2017.09.014. Epub 2017 Sep 18.
• [426] Teriflunomide is an indirect human constitutive androstane receptor (CAR) activator interacting with epidermal growth factor (EGF) signaling. Front Pharmacol. 2018 Oct 11;9:993.
• [427] Growth-suppressive effect of non-steroidal anti-inflammatory drugs on 11 colon-cancer cell lines and fluorescence differential display of genes whose expression is influenced by sulindac. Int J Cancer. 2000 Dec 15;88(6):873-80. doi: 10.1002/1097-0215(20001215)88:6<873::aid-ijc6>3.0.co;2-b.
• [428] Inter-laboratory comparison of human renal proximal tubule (HK-2) transcriptome alterations due to Cyclosporine A exposure and medium exhaustion. Toxicol In Vitro. 2009 Apr;23(3):486-99.
• [429] Successful validation of genomic biomarkers for human immunotoxicity in Jurkat T cells in vitro. J Appl Toxicol. 2015 Jul;35(7):831-41.
• [430] Identification by automated screening of a small molecule that selectively eliminates neural stem cells derived from hESCs but not dopamine neurons. PLoS One. 2009 Sep 23;4(9):e7155.
• [431] Interleukin-19 as a translational indicator of renal injury. Arch Toxicol. 2015 Jan;89(1):101-6.
• [432] Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicol Appl Pharmacol. 2011 May 15;253(1):57-69.
• [433] Convergent transcriptional profiles induced by endogenous estrogen and distinct xenoestrogens in breast cancer cells. Carcinogenesis. 2006 Aug;27(8):1567-78.
• [434] Gene expression in endometrial cancer cells (Ishikawa) after short time high dose exposure to progesterone. Steroids. 2008 Jan;73(1):116-28.
• [435] In vitro aromatic bioactivation of the weak estrogen E(2)alpha and genesis of DNA adducts. Steroids. 2005 Mar;70(3):161-72. doi: 10.1016/j.steroids.2004.11.004.
• [436] Metabolism of melatonin by human cytochromes p450. Drug Metab Dispos. 2005 Apr;33(4):489-94.
• [437] Metabolism of retinoids and arachidonic acid by human and mouse cytochrome P450 1b1. Drug Metab Dispos. 2004 Aug;32(8):840-7.
• [438] Apoptosis contributes to the cytotoxicity induced by amodiaquine and its major metabolite N-desethylamodiaquine in hepatic cells. Toxicol In Vitro. 2020 Feb;62:104669. doi: 10.1016/j.tiv.2019.104669. Epub 2019 Oct 16.
• [439] Genetic variants contributing to daunorubicin-induced cytotoxicity. Cancer Res. 2008 May 1;68(9):3161-8. doi: 10.1158/0008-5472.CAN-07-6381.
• [440] Simulation of interindividual differences in inactivation of reactive para-benzoquinone imine metabolites of diclofenac by glutathione S-transferases in human liver cytosol. Toxicol Lett. 2016 Jul 25;255:52-62.
• [441] Dose- and time-dependent effects of phenobarbital on gene expression profiling in human hepatoma HepaRG cells. Toxicol Appl Pharmacol. 2009 Feb 1;234(3):345-60.
• [442] Different Reactive Metabolites of Nevirapine Require Distinct Glutathione S-Transferase Isoforms for Bioinactivation. Chem Res Toxicol. 2016 Dec 19;29(12):2136-2144. doi: 10.1021/acs.chemrestox.6b00250. Epub 2016 Nov 28.
• [443] Predictive toxicology using systemic biology and liver microfluidic "on chip" approaches: application to acetaminophen injury. Toxicol Appl Pharmacol. 2012 Mar 15;259(3):270-80.
• [444] The molecular basis of genistein-induced mitotic arrest and exit of self-renewal in embryonal carcinoma and primary cancer cell lines. BMC Med Genomics. 2008 Oct 10;1:49.
• [445] Mutant p53 reactivation by PRIMA-1MET induces multiple signaling pathways converging on apoptosis. Oncogene. 2010 Mar 4;29(9):1329-38. doi: 10.1038/onc.2009.425. Epub 2009 Nov 30.
• [446] Proteomics-based identification of differentially abundant proteins from human keratinocytes exposed to arsenic trioxide. J Proteomics Bioinform. 2014 Jul;7(7):166-178.
• [447] Anti-oncogenic and pro-differentiation effects of clorgyline, a monoamine oxidase A inhibitor, on high grade prostate cancer cells. BMC Med Genomics. 2009 Aug 20;2:55. doi: 10.1186/1755-8794-2-55.
• [448] LSD1 activates a lethal prostate cancer gene network independently of its demethylase function. Proc Natl Acad Sci U S A. 2018 May 1;115(18):E4179-E4188.
• [449] Arsenic trioxide promotes ERK1/2-mediated phosphorylation and degradation of BIM(EL) to attenuate apoptosis in BEAS-2B cells. Chem Biol Interact. 2023 Jan 5;369:110304. doi: 10.1016/j.cbi.2022.110304. Epub 2022 Dec 10.
• [450] Pterostilbene attenuates RIPK3-dependent hepatocyte necroptosis in alcoholic liver disease via SIRT2-mediated NFATc4 deacetylation. Toxicology. 2021 Sep;461:152923. doi: 10.1016/j.tox.2021.152923. Epub 2021 Aug 30.
• [451] A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo. Carcinogenesis. 2012 Jul;33(7):1421-9.
• [452] Acute hypersensitivity of pluripotent testicular cancer-derived embryonal carcinoma to low-dose 5-aza deoxycytidine is associated with global DNA Damage-associated p53 activation, anti-pluripotency and DNA demethylation. PLoS One. 2012;7(12):e53003. doi: 10.1371/journal.pone.0053003. Epub 2012 Dec 27.
• [453] 1-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)-3-(2-(dimethylamino)ethyl)imidazolidin-2-one (ZX-42) inhibits cell proliferation and induces apoptosis via inhibiting ALK and its downstream pathways in Karpas299 cells. Toxicol Appl Pharmacol. 2022 Sep 1;450:116156. doi: 10.1016/j.taap.2022.116156. Epub 2022 Jul 6.
• [454] Vitamin D3 induces autophagy of human myeloid leukemia cells. J Biol Chem. 2008 Sep 12;283(37):25596-25605. doi: 10.1074/jbc.M801716200. Epub 2008 Jul 15.
• [455] Tumor necrosis factor-alpha-induced protein 3 as a putative regulator of nuclear factor-kappaB-mediated resistance to O6-alkylating agents in human glioblastomas. J Clin Oncol. 2006 Jan 10;24(2):274-87. doi: 10.1200/JCO.2005.02.9405. Epub 2005 Dec 19.
• [456] Folic acid supplementation dysregulates gene expression in lymphoblastoid cells--implications in nutrition. Biochem Biophys Res Commun. 2011 Sep 9;412(4):688-92. doi: 10.1016/j.bbrc.2011.08.027. Epub 2011 Aug 16.
• [457] Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain. Toxicol Lett. 2015 Apr 16;234(2):139-50.
• [458] Epigallocatechin-3-gallate (EGCG) protects against chromate-induced toxicity in vitro. Toxicol Appl Pharmacol. 2012 Jan 15;258(2):166-75.
• [459] Quantitative phosphoproteomics reveal cellular responses from caffeine, coumarin and quercetin in treated HepG2 cells. Toxicol Appl Pharmacol. 2022 Aug 15;449:116110. doi: 10.1016/j.taap.2022.116110. Epub 2022 Jun 7.
• [460] Identification of biomarkers and outcomes of endocrine disruption in human ovarian cortex using In Vitro Models. Toxicology. 2023 Feb;485:153425. doi: 10.1016/j.tox.2023.153425. Epub 2023 Jan 5.
• [461] BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia. Blood. 2012 Oct 4;120(14):2843-52.
• [462] Actinomycin D upregulates proapoptotic protein Puma and downregulates Bcl-2 mRNA in normal peripheral blood lymphocytes. Anticancer Drugs. 2007 Aug;18(7):763-72. doi: 10.1097/CAD.0b013e3280adc905.
• [463] Improved apoptotic cell death in drug-resistant non-small-cell lung cancer cells by tumor necrosis factor-related apoptosis-inducing ligand-based treatment. J Pharmacol Exp Ther. 2014 Mar;348(3):360-71. doi: 10.1124/jpet.113.210054. Epub 2013 Dec 17.
• [464] Aspirin induces apoptosis in human leukemia cells independently of NF-kappaB and MAPKs through alteration of the Mcl-1/Noxa balance. Apoptosis. 2010 Feb;15(2):219-29. doi: 10.1007/s10495-009-0424-9.
• [465] In vitro effects of aldehydes present in tobacco smoke on gene expression in human lung alveolar epithelial cells. Toxicol In Vitro. 2013 Apr;27(3):1072-81.
• [466] Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor. Sci Rep. 2014 Sep 26;4:6437. doi: 10.1038/srep06437.
• [467] The farnesoid X receptor FXRalpha/NR1H4 acquired ligand specificity for bile salts late in vertebrate evolution. Am J Physiol Regul Integr Comp Physiol. 2007 Sep;293(3):R1400-9. doi: 10.1152/ajpregu.00781.2006. Epub 2007 Jun 13.
• [468] Investigation of imatinib and other approved drugs as starting points for antidiabetic drug discovery with FXR modulating activity. Biochem Pharmacol. 2012 Jun 15;83(12):1674-81. doi: 10.1016/j.bcp.2012.02.027. Epub 2012 Mar 7.
• [469] Organochloride pesticides modulated gut microbiota and influenced bile acid metabolism in mice. Environ Pollut. 2017 Jul;226:268-276.
• [470] Overexpression of glutathione-S-transferase, MGSTII, confers resistance to busulfan and melphalan. Cancer Invest. 2005;23(1):19-25.
• [471] [Mechanism of arsenic trioxide induced apoptosis in cultured human lens epithelium cells]. Zhonghua Yan Ke Za Zhi. 2008 Oct;44(10):916-20.
• [472] Inhibition of fatty acid synthase induces endoplasmic reticulum stress in tumor cells. Cancer Res. 2007 Feb 1;67(3):1262-9. doi: 10.1158/0008-5472.CAN-06-1794.
• [473] Low Autophagy (ATG) Gene Expression Is Associated with an Immature AML Blast Cell Phenotype and Can Be Restored during AML Differentiation Therapy. Oxid Med Cell Longev. 2018 Mar 18;2018:1482795. doi: 10.1155/2018/1482795. eCollection 2018.
• [474] Inhibitory effect of PXR on ammonia-induced hepatocyte autophagy via P53. Toxicol Lett. 2018 Oct 1;295:153-161. doi: 10.1016/j.toxlet.2018.06.1066. Epub 2018 Jun 14.
• [475] TNF enhances trovafloxacin-induced in vitro hepatotoxicity by inhibiting protective autophagy. Toxicol Lett. 2021 May 15;342:73-84. doi: 10.1016/j.toxlet.2021.02.009. Epub 2021 Feb 17.
• [476] Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization. Autophagy. 2016 Nov;12(11):2213-2229. doi: 10.1080/15548627.2016.1213927. Epub 2016 Sep 16.
• [477] Down-regulation of CYLD as a trigger for NF-B activation and a mechanism of apoptotic resistance in hepatocellular carcinoma cells. Int J Oncol. 2011 Jan;38(1):121-31.
• [478] From transient transcriptome responses to disturbed neurodevelopment: role of histone acetylation and methylation as epigenetic switch between reversible and irreversible drug effects. Arch Toxicol. 2014 Jul;88(7):1451-68.
• [479] A new in vitro method for identifying chemical sensitizers combining peptide binding with ARE/EpRE-mediated gene expression in human skin cells. Cutan Ocul Toxicol. 2010 Sep;29(3):171-92.
• [480] Identification of transcriptome signatures and biomarkers specific for potential developmental toxicants inhibiting human neural crest cell migration. Arch Toxicol. 2016 Jan;90(1):159-80.
• [481] Effect of organic anion-transporting polypeptide 1B1 (OATP1B1) polymorphism on the single- and multiple-dose pharmacokinetics of enalapril in healthy Chinese adult men. Clin Ther. 2011 May;33(5):655-63. doi: 10.1016/j.clinthera.2011.04.018.
• [482] Differential interaction of 3-hydroxy-3-methylglutaryl-coa reductase inhibitors with ABCB1, ABCC2, and OATP1B1. Drug Metab Dispos. 2005 Apr;33(4):537-46.
• [483] Polymorphic organic anion transporting polypeptide 1B1 is a major determinant of repaglinide pharmacokinetics. Clin Pharmacol Ther. 2005 Jun;77(6):468-78. doi: 10.1016/j.clpt.2005.01.018.
• [484] SLC19A1, SLC46A1 and SLCO1B1 polymorphisms as predictors of methotrexate-related toxicity in Portuguese rheumatoid arthritis patients. Toxicol Sci. 2014 Nov;142(1):196-209. doi: 10.1093/toxsci/kfu162. Epub 2014 Aug 14.
• [485] SLCO1B1 variants and statin-induced myopathy--a genomewide study. N Engl J Med. 2008 Aug 21;359(8):789-99.
• [486] Transport of fluorescent chenodeoxycholic acid via the human organic anion transporters OATP1B1 and OATP1B3. J Lipid Res. 2006 Jun;47(6):1196-202.
• [487] Transcellular movement of hydroxyurea is mediated by specific solute carrier transporters. Exp Hematol. 2011 Apr;39(4):446-56.
• [488] Severe toxicities after irinotecan-based chemotherapy in a patient with lung cancer: a homozygote for the SLCO1B1*15 allele. Ther Drug Monit. 2007 Oct;29(5):666-8. doi: 10.1097/FTD.0b013e3181357364.