Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMC5Q8X)

• Drug Name: Berberine Drug Info
• Synonyms: berberine; 2086-83-1; Berberin; Umbellatine; UNII-0I8Y3P32UF; 0I8Y3P32UF; CHEBI:16118; EINECS 218-229-1; Berberal; BRN 3570374; ST055798; 9,10-Dimethoxy-2,3-(methylenedioxy)-7,8,13,13a-tetrahydroberbinium; Benzo(g)-1,3-benzodioxolo(5,6-a)quinolizinium, 5,6-dihydro-9,10-dimethoxy-; 9,10-dimethoxy-5,6-dihydro[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinolin-7-ium; Berbamine sulphate acid; CHEMBL12089; 7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-(methylenedioxy)berbinium; BERBINIUM, 7,8,13,13a-TETRAHYDRO-9,10-DIMETHOXY-2,3-(METHYLE
• Cross-matching ID:
  PubChem CID: 2353
  ChEBI ID: CHEBI:16118
  CAS Number: CAS 2086-83-1
  TTD Drug ID: DMC5Q8X
  VARIDT Drug ID: DR00307

Molecule-Related Drug Atlas

Drug(s) Targeting Telomerase reverse transcriptase (TERT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
GV1001	DMHULRK	Pancreatic cancer	2C10	Phase 3	[11]
Imetelstat	DMONWJ4	Myelodysplastic syndrome	2A37	Phase 2/3	[12]
VM1500A	DM9YSSY	Human immunodeficiency virus-1 infection	1C62	Phase 2/3	[13]
Dendritic cell vaccine	DML4PMG	Ovarian cancer	2C73	Phase 2	[14]
GRNVAC1	DMAHOEP	Acute myeloid leukaemia	2A60	Phase 2	[15]
Vx-001	DMDKWA3	Breast cancer	2C60-2C65	Phase 2	[16]
CB-10-01	DM2IFYZ	Melanoma	2C30	Phase 2	[17]
Epithalon	DMWSGZU	Ocular inflammation	9C61.24	Phase 1/2	[18]
OBP-301	DM9MF08	Breast cancer	2C60-2C65	Phase 1/2	[19]
KML-001	DM1D2O0	Solid tumour/cancer	2A00-2F9Z	Phase 1	[20]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[75]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[76]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[77]
Selenium	DM25CGV	N. A.	N. A.	Approved	[78]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[79]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[80]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[81]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[82]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[83]

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[21]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[22]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[23]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[24]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[23]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[23]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[25]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[23]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[26]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[27]

Drug(s) Transported By Organic cation transporter 1 (SLC22A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dinoprostone	DMTYOPD	Medical abortion	JA00.1Z	Approved	[28]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[29]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[30]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[31]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[21]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[32]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[33]
Quinine	DMSWYF5	Malaria	1F40-1F45	Approved	[34]
Dopamine	DMPGUCF	Acromegaly	5A60.0	Approved	[35]
Propranolol	DM79NTF	Angina pectoris	BA40	Approved	[36]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[37]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[38]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[39]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[40]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[41]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[42]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[43]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[44]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[45]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[46]

Drug(s) Affected By Aryl hydrocarbon receptor (AHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[47]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[48]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[49]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[50]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[51]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[52]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[55]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[56]

Drug(s) Affected By Insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[62]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[63]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[64]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[66]

Drug(s) Affected By Protein arginine N-methyltransferase 5 (PRMT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[68]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[62]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[74]

Drug(s) Affected By Serine/threonine-protein kinase Chk1 (CHEK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[84]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[85]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[86]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[87]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[88]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[91]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[92]

Drug(s) Affected By Histone acetyltransferase type B catalytic subunit (HAT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[94]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[95]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[62]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[97]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]

Drug(s) Affected By Lysine-specific demethylase 6B (KDM6B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[99]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[100]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[101]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[102]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[103]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[104]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[105]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[106]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[107]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[108]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[109]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[110]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[111]

Drug(s) Affected By Lysine-specific demethylase 6A (KDM6A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[112]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[113]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[100]

Drug(s) Affected By Bcl-2-like protein 11 (BCL2L11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[114]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[115]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[116]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[117]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[118]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[120]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[121]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]

Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like (BNIP3L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[122]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[124]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[125]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[126]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[127]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[128]

Drug(s) Affected By Lysine-specific histone demethylase 1A (KDM1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[130]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[131]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[128]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[62]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[66]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[133]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[134]

Drug(s) Affected By Histone H2B type 1-K (H2BC12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[135]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[136]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[119]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[137]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[139]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[140]

Drug(s) Affected By Lysine-specific demethylase 4A (KDM4A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[129]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[141]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[142]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[100]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[101]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[143]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 2 (NR1I2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[144]
Vidarabine	DM0N85H	Hepatosplenic T-cell lymphoma		Approved	[144]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[145]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[146]
Secobarbital	DM14RF5	Epilepsy	8A60-8A68	Approved	[147]
Etidronic acid	DM1XHYJ	Bone Paget disease		Approved	[144]
Tiaprofenic acid	DM23D7J	Osteoarthritis	FA00-FA05	Approved	[144]
Bromperidol	DM24XYQ	Schizophrenia	6A20	Approved	[144]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[148]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[149]

Drug(s) Affected By Serine/threonine-protein kinase Chk2 (CHEK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[150]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[84]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[151]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[90]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[152]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[83]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[153]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[153]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[154]

Drug(s) Affected By Histone-lysine N-methyltransferase NSD2 (NSD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[155]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[156]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[153]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[153]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[157]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[158]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[159]

Drug(s) Affected By Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[160]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[161]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[162]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[163]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[164]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[165]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[166]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[135]
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[168]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[169]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[170]
Fructose	DM43AN2	Vomiting	MD90	Approved	[171]
Ketoprofen	DMRKXPT	Bursitis		Approved	[171]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[172]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[173]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[174]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[175]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[176]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[177]

Drug(s) Affected By Collagen alpha-1(I) chain (COL1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[171]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[178]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[179]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[180]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[182]
Ceruletide	DM2WE5K	Caerulein stimulated gastric and pancreatic secretion	5A4Y	Approved	[183]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[184]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[185]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[186]

Drug(s) Affected By Collagen alpha-1(II) chain (COL2A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[187]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[188]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[189]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[190]
Indomethacin	DMSC4A7	Bursitis		Approved	[191]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[191]

Drug(s) Affected By Osteocalcin (BGLAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[192]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[194]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[195]
Pamidronate	DMB4AVP	Bone Paget disease		Approved	[196]
Falecalcitrol	DMBI9ZJ	Hyperparathyroidism	5A51	Approved	[197]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[198]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[199]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[200]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[201]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[202]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[203]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[204]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[205]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[206]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[207]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[208]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[209]

Drug(s) Affected By Histone H2A type 1-B/E (H2AC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[210]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[211]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[139]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[189]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[212]

Drug(s) Affected By Histone H2B type 1-J (H2BC11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[213]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[70]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[62]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[140]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[189]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[74]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
OTX-015	DMI8RG1	Acute myeloid leukaemia	2A60	Phase 1/2	[214]

Drug(s) Affected By Cathepsin D (CTSD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[215]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[135]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[216]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[218]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[219]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[220]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]

Drug(s) Affected By Procathepsin L (CTSL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[221]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[222]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[62]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[223]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[224]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[225]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[222]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]

Drug(s) Affected By Insulin-like growth factor 1 receptor (IGF1R)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[226]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[227]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[228]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[229]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[230]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[231]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[232]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[153]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[153]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[233]

Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[234]
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[235]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[236]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[237]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[238]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[136]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[239]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[240]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[241]

Drug(s) Affected By SPARC (SPARC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[242]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[221]
LY2835219	DM93VBZ	Breast cancer	2C60-2C65	Approved	[243]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[243]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[244]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[245]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[246]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[247]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[248]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[249]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[250]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[251]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[252]
Selenium	DM25CGV	N. A.	N. A.	Approved	[253]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[254]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[255]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[256]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[210]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[257]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[258]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[105]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[259]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[260]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[259]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[261]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[262]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[263]

Drug(s) Affected By Histone H2A type 1 (H2AC11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[210]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[136]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[264]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[265]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[153]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[153]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[139]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[266]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]

Drug(s) Affected By Histone H2B type F-M (H2BW2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[267]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[268]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[269]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[270]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[171]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[210]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[271]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[272]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[173]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[273]

Drug(s) Affected By Osteopontin (SPP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[178]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[47]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[274]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[275]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[230]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[276]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[277]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[119]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[278]

Drug(s) Affected By DNA topoisomerase 1 (TOP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Teniposide	DMLW57T	Acute lymphoblastic leukaemia	2A85	Approved	[171]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[279]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[280]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[281]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[233]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[132]

Drug(s) Affected By Cyclin-dependent kinase 4 (CDK4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[282]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[283]
Selenium	DM25CGV	N. A.	N. A.	Approved	[284]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[285]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[256]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[286]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[287]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[288]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]

Drug(s) Affected By Hepatocyte growth factor (HGF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[289]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[290]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[291]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[292]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[292]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[77]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[293]
Etodolac	DM6WJO9	Osteoarthritis	FA00-FA05	Approved	[294]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[295]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[296]

Drug(s) Affected By Sucrase-isomaltase, intestinal (SI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[297]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[298]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[153]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[153]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[299]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[300]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[47]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[175]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[177]
Selenium	DM25CGV	N. A.	N. A.	Approved	[167]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[301]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[261]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[302]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[303]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[304]

Drug(s) Affected By Fatty acid-binding protein, adipocyte (FABP4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[291]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[305]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[95]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[306]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[291]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Ursodeoxycholic acid	DMCUT21	Cholelithiasis	DC11	Approved	[307]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[308]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[309]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[310]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[311]
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[312]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[313]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[314]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[315]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[316]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[281]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[317]

Drug(s) Affected By Aggrecan core protein (ACAN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[187]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[157]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[318]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[190]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[319]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[320]
Diacerein	DMN2Q5I	N. A.	N. A.	Phase 4	[321]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[217]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[134]

Drug(s) Affected By Platelet glycoprotein 4 (CD36)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[322]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[323]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[324]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[325]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[326]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[60]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[327]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[328]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[329]

Drug(s) Affected By CCAAT/enhancer-binding protein beta (CEBPB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[210]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[280]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[330]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[331]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[332]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[333]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[119]

Drug(s) Affected By Cadherin-2 (CDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[289]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[291]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[334]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[335]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[336]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[337]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[338]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[339]

Drug(s) Affected By Acetylcholinesterase (ACHE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[340]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[341]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[342]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[280]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[343]
L-Glutamic Acid	DM4PUDW	Schizophrenia	6A20	Approved	[342]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[344]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[345]
Neostigmine	DM6T2J3	Myasthenia gravis	8C6Y	Approved	[346]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]

Drug(s) Affected By Histone H2B type 1-O (H2BC17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[153]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[153]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[123]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[347]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[348]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[349]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[350]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[351]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[352]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[273]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[353]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[161]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[354]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[356]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[357]

Drug(s) Affected By G1/S-specific cyclin-E1 (CCNE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[210]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[358]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[68]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[260]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[359]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[360]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[361]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[362]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[363]

Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[84]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[364]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[358]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[365]
Selenium	DM25CGV	N. A.	N. A.	Approved	[284]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[260]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[366]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[302]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[286]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[288]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[180]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[85]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[105]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[367]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[368]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[230]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[369]
Fructose	DM43AN2	Vomiting	MD90	Approved	[370]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[180]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[333]

Drug(s) Affected By DNA cytosine-5)-methyltransferase 1 (DNMT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[102]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[93]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[371]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[230]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[372]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[131]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[373]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[374]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[375]

Drug(s) Affected By G1/S-specific cyclin-D2 (CCND2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[135]
Selenium	DM25CGV	N. A.	N. A.	Approved	[284]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[256]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[288]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[376]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[377]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[378]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[379]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[380]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[381]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[207]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[273]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[382]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[383]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[384]
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[228]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[356]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[385]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[289]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[386]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[230]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[238]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[387]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[388]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[389]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[338]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[390]

Drug(s) Affected By Sterol regulatory element-binding protein 1 (SREBF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Ritonavir	DMU764S	Human immunodeficiency virus infection	1C62	Approved	[171]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[180]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[391]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[392]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[393]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[213]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[394]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[395]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[181]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[396]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[305]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[397]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[398]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[369]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[399]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[400]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[378]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[401]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[402]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[103]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[354]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[85]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[106]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[403]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[260]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[404]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[405]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[406]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[407]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[204]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[408]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[409]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[410]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[411]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[412]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[413]

Drug(s) Affected By Growth/differentiation factor 5 (GDF5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[266]
Prednisolone	DMQ8FR2	Acute adrenal insufficiency		Approved	[414]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[320]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[134]

Drug(s) Affected By Nicotinamide phosphoribosyltransferase (NAMPT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[415]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[136]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[416]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[417]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[233]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[153]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[70]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[233]

Drug(s) Affected By Collagenase 3 (MMP13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[418]
Clindamycin	DM15HL8	Acne vulgaris	ED80	Approved	[419]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[418]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[420]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[421]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[422]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[423]
Doxycycline	DM7ICNU	Acne vulgaris	ED80	Approved	[419]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[339]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[424]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[425]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[161]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[403]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[426]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[427]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[163]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[428]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[360]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[429]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[430]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[122]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[431]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[432]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[368]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[94]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[42]
Fructose	DM43AN2	Vomiting	MD90	Approved	[370]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[433]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[434]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[435]

Drug(s) Affected By Transcription factor SOX-9 (SOX9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[401]
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[436]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[119]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[437]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[153]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[128]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[438]

Drug(s) Affected By CCAAT/enhancer-binding protein alpha (CEBPA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[439]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[440]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[441]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[442]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[293]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[437]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Efavirenz	DMC0GSJ	Human immunodeficiency virus infection	1C62	Approved	[293]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[328]

Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[443]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[444]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[445]
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[446]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[447]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[87]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[448]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[449]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1C (CDKN1C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[420]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[288]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[450]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[450]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[112]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[451]

Drug(s) Affected By Isocitrate dehydrogenase subunit alpha, mitochondrial (IDH3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[452]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[453]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[119]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[62]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[454]
Bortezomib	DMNO38U	Leukemia		Approved	[455]
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[455]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[456]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[158]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[457]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[458]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[210]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[272]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[459]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[460]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[105]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[461]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[462]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[463]

Drug(s) Affected By Protein arginine N-methyltransferase 2 (PRMT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[464]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[128]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[139]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[347]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[141]

Drug(s) Affected By Integrin alpha-1 (ITGA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[465]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[62]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[466]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[467]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[468]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[320]

Drug(s) Affected By Histone H2B type 1-D (H2BC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[135]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[136]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[469]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[153]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[153]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[199]

Drug(s) Affected By Small ribosomal subunit protein eS6 (RPS6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[470]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[280]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[471]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[472]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[96]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[473]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[474]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[475]
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[380]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]

Drug(s) Affected By Histone H4 (H4C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[210]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[85]
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[107]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[280]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[476]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[152]

Drug(s) Affected By Histone H2B type 1-C/E/F/G/I (H2BC10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[211]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[139]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[62]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[140]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[189]

Drug(s) Affected By Histone H3.1 (H3C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[210]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[477]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[423]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[264]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[153]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[153]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]

Drug(s) Affected By Histone H3.3 (H3-3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[135]
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[280]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[478]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[158]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[479]

Drug(s) Affected By Cytochrome c (CYCS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[480]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[481]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[257]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[459]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[482]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[483]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[201]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[484]
Pefloxacin	DM49IGF	Gonococcal urethritis	1A70.0Y	Approved	[485]

Drug(s) Affected By Cyclin-dependent kinase 6 (CDK6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[283]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[209]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[444]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[359]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[280]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[87]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[486]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[119]

Drug(s) Affected By Collagen alpha-1(X) chain (COL10A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[190]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[141]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[487]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[488]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[267]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[413]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[210]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[271]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[180]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[459]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[354]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[289]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[489]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[260]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[207]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[490]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[105]
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[491]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[256]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[492]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[493]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[87]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[42]

Drug(s) Affected By Histone acetyltransferase p300 (EP300)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[494]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[495]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[156]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[437]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[496]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[62]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[497]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[498]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[499]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]

Drug(s) Affected By BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[289]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[420]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[125]
Quinolones	DM5GVHU	Bacterial infection	1A00-1C4Z	Approved	[500]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[126]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[501]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[233]

Drug(s) Affected By TNF receptor-associated factor 1 (TRAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[502]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[477]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[156]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[503]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[504]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[139]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[505]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[497]

Drug(s) Affected By Sequestosome-1 (SQSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[506]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[507]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[508]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[242]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[509]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[107]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[256]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[510]

Drug(s) Affected By Runt-related transcription factor 2 (RUNX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[178]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[511]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[512]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[513]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[195]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[156]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[514]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[128]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[233]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[515]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[516]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[517]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[480]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[431]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[518]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[105]
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[462]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[201]

Drug(s) Affected By Nuclear receptor subfamily 1 group I member 3 (NR1I3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[148]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[519]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[440]
Artemether	DM48QOT	Malaria	1F40-1F45	Approved	[520]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[521]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[522]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[55]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[523]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[524]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]

Drug(s) Affected By Histone-lysine N-methyltransferase SETDB1 (SETDB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[525]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[133]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[526]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[155]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[155]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[527]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[452]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[250]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[166]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[528]
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[529]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[530]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[531]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[532]

Drug(s) Affected By Histone H3.1t (H3-4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[533]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[534]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[476]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[535]
Romidepsin	DMT5GNL	Cutaneous T-cell lymphoma	2B01	Approved	[536]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[537]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[141]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[538]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[539]

Drug(s) Affected By Histone H2A type 2-A (H2AC18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[264]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[466]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[540]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[123]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[158]

Drug(s) Affected By Histone H2A type 3 (H2AC25)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[135]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[541]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[212]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[123]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[141]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[542]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[526]

Drug(s) Affected By Actin-histidine N-methyltransferase (SETD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[62]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[158]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[526]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[155]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[543]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[544]

Drug(s) Affected By E3 ubiquitin-protein ligase DZIP3 (DZIP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[545]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[479]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[546]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[101]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[526]

Drug(s) Affected By FUN14 domain-containing protein 1 (FUNDC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[478]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[63]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[74]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[134]
MG-132	DMKA2YS	N. A.	N. A.	Preclinical	[547]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[488]

Drug(s) Affected By Thiosulfate:glutathione sulfurtransferase (TSTD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[62]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[63]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[548]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[134]

Drug(s) Affected By N-lysine methyltransferase SETD6 (SETD6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[201]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[139]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[123]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[543]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[67]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[526]

Drug(s) Affected By Transcription factor Sp7 (SP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[511]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[549]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[550]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[550]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[134]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[551]
alpha-ketoglutaric acid	DM5LFYN	Discovery agent	N.A.	Investigative	[552]
PD98059	DMZC90M	Cardiac arrest	MC82	Investigative	[550]

Drug(s) Affected By Histone-lysine N-methyltransferase SETD7 (SETD7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[553]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[554]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[212]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[74]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[548]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[555]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[100]

Drug(s) Affected By Histone deacetylase 2 (HDAC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[556]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[557]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[525]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[558]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[559]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[62]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[188]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[560]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[123]

Drug(s) Affected By CREB-binding protein (CREBBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[288]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[495]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[107]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[561]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[496]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[498]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[499]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[63]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[189]

Drug(s) Affected By Proteoglycan 4 (PRG4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[156]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[562]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[347]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[563]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[134]

Drug(s) Affected By Histone H2A type 1-C (H2AC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[564]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[417]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[139]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[466]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[565]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[566]

Drug(s) Affected By Histone H2B type 1-H (H2BC9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[477]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[136]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[423]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[157]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[123]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[74]

Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-1 (SIRT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[567]
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[107]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[568]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[569]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[570]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[571]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[572]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[59]
Olaparib	DM8QB1D	Ovarian cancer	2C73	Approved	[573]

Drug(s) Affected By Aurora kinase B (AURKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[401]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[102]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[85]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[574]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[575]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[153]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[153]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[70]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[233]

Drug(s) Affected By Histone H2A type 1-H (H2AC12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[210]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[264]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[576]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[62]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[140]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[212]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[577]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[578]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[579]

Drug(s) Affected By Protein arginine N-methyltransferase 6 (PRMT6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[464]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[580]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[158]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[141]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[101]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[581]

Drug(s) Affected By Bcl-2-binding component 3, isoforms 3/4 (BBC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[123]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[105]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[107]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[314]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[582]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[420]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[583]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[584]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[585]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[121]

Drug(s) Affected By Histone-lysine N-methyltransferase SETDB2 (SETDB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[129]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[554]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[99]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[63]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[586]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[586]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]

Drug(s) Affected By Protein arginine N-methyltransferase 1 (PRMT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[67]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[464]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[587]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[588]
Dapsone	DM4LT8A	Acne vulgaris	ED80	Approved	[589]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[156]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[437]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[62]

Drug(s) Affected By Histone H2B type 1-N (H2BC15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[590]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[98]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[123]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[479]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[591]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[526]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[592]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[593]
Deguelin	DMXT7WG	Esophageal squamous cell carcinoma	2E60.1	Investigative	[594]

Drug(s) Affected By Histone H2A type 1-J (H2AC14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[210]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[264]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[595]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[579]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[596]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[526]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[597]

Drug(s) Affected By Histone H2B type 1-M (H2BC14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[122]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[280]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[77]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[140]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[157]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[590]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[159]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[141]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[579]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[598]

Drug(s) Affected By Histone H2B type 1-L (H2BC13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[212]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[123]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[159]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[348]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[101]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[599]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[592]
Lithium chloride	DMHYLQ2	Discovery agent	N.A.	Investigative	[600]

Drug(s) Affected By Osteomodulin (OMD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[601]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[602]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]

Drug(s) Affected By Histone deacetylase 8 (HDAC8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[122]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[119]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[152]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[211]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[543]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[100]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[101]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[603]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[134]

Drug(s) Affected By Histone-lysine N-methyltransferase SETD2 (SETD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[604]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[605]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[211]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[543]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[100]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[67]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[143]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[133]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[606]

Drug(s) Affected By Histone-lysine N-methyltransferase SETD5 (SETD5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[437]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[139]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[607]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[608]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[212]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[609]

Drug(s) Affected By Histone-lysine N-methyltransferase SMYD3 (SMYD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[122]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[136]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[152]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[62]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[63]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[586]

Drug(s) Affected By N-lysine methyltransferase KMT5A (KMT5A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[60]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[554]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[610]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[611]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Curcumin	DMQPH29	Solid tumour/cancer	2A00-2F9Z	Phase 3	[612]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[606]

Drug(s) Affected By Protein arginine N-methyltransferase 8 (PRMT8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[464]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[158]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[100]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[134]

Drug(s) Affected By NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[567]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[613]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[614]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[613]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Hesperetin	DMKER83	High blood cholesterol level	5C80.00	Approved	[615]
Chloroquine	DMSI5CB	Malaria	1F40-1F45	Approved	[614]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[616]

Drug(s) Affected By Protein arginine N-methyltransferase 7 (PRMT7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[68]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
(L-)-S-adenosyl-L-homocysteine	DMDUN83	Discovery agent	N.A.	Investigative	[68]

Drug(s) Affected By DNA (DNMT3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[372]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[617]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[375]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[153]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[153]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[70]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[66]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[554]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[607]

Drug(s) Affected By Lysine-specific demethylase 5B (KDM5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[127]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[138]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[554]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[99]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[212]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]

Drug(s) Affected By Histone deacetylase 9 (HDAC9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[122]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[89]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[618]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[112]
Pirfenidone	DM6VZFQ	Idiopathic pulmonary fibrosis	CB03.4	Approved	[618]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[328]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[139]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[466]
Indomethacin	DMSC4A7	Bursitis		Approved	[191]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[619]

Drug(s) Affected By Aurora kinase C (AURKC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[66]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[134]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[526]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[620]

Drug(s) Affected By Histone deacetylase 5 (HDAC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[437]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[72]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[99]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[621]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[212]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[158]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[546]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[101]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[622]

Drug(s) Affected By Long-chain fatty acid transport protein 5 (SLC27A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[213]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[623]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[61]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[188]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[73]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[624]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[347]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[71]

Drug(s) Affected By DNA topoisomerase 2-alpha (TOP2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[625]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[626]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[402]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[627]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[477]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[281]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[57]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[58]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[217]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[628]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Telomerase reverse transcriptase (TERT)	TTUJFD0	TERT_HUMAN	Inhibitor	[1]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Organic cation transporter 1 (SLC22A1)	DTT79CX	S22A1_HUMAN	Substrate	[2]
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[3]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[4]
Acetylcholinesterase (ACHE)	OT2H8HG6	ACES_HUMAN	Gene/Protein Processing	[5]
Actin-histidine N-methyltransferase (SETD3)	OTO5RAU2	SETD3_HUMAN	Gene/Protein Processing	[6]
Aggrecan core protein (ACAN)	OTUOCW8K	PGCA_HUMAN	Gene/Protein Processing	[7]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[8]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[8]
Aryl hydrocarbon receptor (AHR)	OTFE4EYE	AHR_HUMAN	Gene/Protein Processing	[9]
Aurora kinase B (AURKB)	OTIY4VHU	AURKB_HUMAN	Gene/Protein Processing	[6]
Aurora kinase C (AURKC)	OTJMOW9V	AURKC_HUMAN	Gene/Protein Processing	[6]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Protein Interaction/Cellular Processes	[10]

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