Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMWQIJX)

• Drug Name: Celastrol Drug Info
• Synonyms: Tripterin; Tripterine; Celastrol, Celastrus scandens; (2R,4aS,6aR,6aS,14aS,14bR)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid; (2R,4aS,6aS,12bR,14aS,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylic acid; 3-Hydroxy-24-nor-2-oxo-1(10),3,5,7-friedelatetraen-29-oic Acid

Indication

Disease Entry	ICD 11	Status	REF
Motor neurone disease	8B60	Preclinical	[1]

• Cross-matching ID:
  PubChem CID: 122724
  ChEBI ID: CHEBI:63959
  CAS Number: CAS 34157-83-0
  TTD Drug ID: DMWQIJX

Molecule-Related Drug Atlas

Drug(s) Targeting Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[6]
Nafamostat	DMU1XOD	Pancreatitis	DC31-DC34	Approved	[7]
Pentoxifylline	DMU3DNC	Alcoholic hepatitis	DB94.1	Approved	[8]
Lenalidomide	DM6Q7U4	Adult T-cell leukemia/lymphoma		Approved	[9]
Enbrel	DM7RNP3	Arthritis	FA20	Approved	[10]
Golimumab	DMHZV7X	Psoriatic arthritis	FA21	Approved	[11]
Certolizumab	DM5CL9Z	Rheumatoid arthritis	FA20	Approved	[12]
Etanercept	DMCV109	Arthritis	FA20	Approved	[13]
Adalimumab	DMQMV1B	Crohn disease	DD70	Approved	[14]
Infliximab	DMH7OIA	Crohn disease	DD70	Approved	[15]
Indomethacin	DMSC4A7	Bursitis		Approved	[311]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[312]
Fructose	DM43AN2	Vomiting	MD90	Approved	[227]
Ketoprofen	DMRKXPT	Bursitis		Approved	[227]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[313]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[314]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[315]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[316]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[317]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[318]

Drug(s) Targeting Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[16]
Rilonacept	DMGLUQS	Arthritis	FA20	Approved	[17]
Gallium nitrate	DMF9O6B	Hypercalcaemia	5B91.0	Approved	[18]
Canakinumab	DM8HLO5	Autosomal dominant familial periodic fever		Approved	[11]
Diacerein	DMN2Q5I	N. A.	N. A.	Phase 4	[19]
XOMA 052	DMOKQV7	Type-2 diabetes	5A11	Phase 3	[20]
ABT-981	DM6PTIX	Osteoarthritis	FA00-FA05	Phase 2	[21]
AC-201	DMB0TNL	Type-2 diabetes	5A11	Phase 2	[22]
LY-2189102	DMU81BH	Cardiovascular disease	BA00-BE2Z	Phase 2	[23]
TT-301	DM4QV8Y	Alzheimer disease	8A20	Phase 1	[24]

Drug(s) Affected By Putative glutamine amidotransferase-like class 1 domain-containing protein 3B, mitochondrial (GATD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[25]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[26]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[25]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[28]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[29]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[30]
Aminoglutethimide	DMWFHMZ	Cushing disease	5A70	Approved	[31]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[32]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[33]

Drug(s) Affected By Cell division cycle 7-related protein kinase (CDC7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[40]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[41]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[42]

Drug(s) Affected By Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (PIK3CD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[43]
Selenium	DM25CGV	N. A.	N. A.	Approved	[33]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[28]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[42]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[46]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[47]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[48]

Drug(s) Affected By Baculoviral IAP repeat-containing protein 5 (BIRC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[49]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[50]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[51]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[52]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[53]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[25]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[54]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[55]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[56]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[57]

Drug(s) Affected By Transmembrane protease serine 2 (TMPRSS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[58]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[58]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Selenium	DM25CGV	N. A.	N. A.	Approved	[33]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[58]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[58]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[58]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[58]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[58]
Fluphenazine	DMIT8LX	Psychotic disorder	6A20-6A25	Approved	[58]

Drug(s) Affected By Insulin-induced gene 1 protein (INSIG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[61]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[64]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[26]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[63]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[65]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[67]

Drug(s) Affected By Nibrin (NBN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[26]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[71]
Pentamidine	DMHZJCG	African trypanosomiasis	1F51	Approved	[72]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[28]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[73]

Drug(s) Affected By E3 ubiquitin-protein ligase MYCBP2 (MYCBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[76]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[77]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[28]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[47]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[78]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[79]
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[80]

Drug(s) Affected By Carbonyl reductase 3 (CBR3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[81]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[71]
Bortezomib	DMNO38U	Leukemia		Approved	[83]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[28]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[81]
Oxcarbazepine	DM5PU6O	Epilepsy	8A60-8A68	Approved	[85]

Drug(s) Affected By High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[86]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[88]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[89]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[90]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[91]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[32]

Drug(s) Affected By E3 ubiquitin-protein ligase listerin (LTN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[92]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[67]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[67]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[67]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[67]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[76]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[67]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]

Drug(s) Affected By Activator of 90 kDa heat shock protein ATPase homolog 1 (AHSA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[71]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[76]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[28]
Sodium phenylbutyrate	DMXLBCQ	Spinal muscular atrophy	8B61	Approved	[95]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[96]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[32]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[33]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[97]

Drug(s) Affected By BAG family molecular chaperone regulator 3 (BAG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[98]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[99]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[100]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[71]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[99]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[101]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[102]

Drug(s) Affected By Epidermal growth factor receptor (EGFR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
BIBW 2992	DMTKD7Q	Non-small-cell lung cancer	2C25.Y	Approved	[103]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[104]
Erlotinib	DMCMBHA	Adrenal gland neoplasm		Approved	[105]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[106]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[107]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[108]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[109]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Selenium	DM25CGV	N. A.	N. A.	Approved	[110]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[111]

Drug(s) Affected By Low-density lipoprotein receptor (LDLR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[112]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[113]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[112]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[114]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[115]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[44]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[26]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[116]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[117]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[118]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[119]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[121]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[122]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[123]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[124]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[125]

Drug(s) Affected By Heat shock protein HSP 90-alpha (HSP90AA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[126]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[129]
Selenium	DM25CGV	N. A.	N. A.	Approved	[33]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[130]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]

Drug(s) Affected By Amino acid transporter heavy chain SLC3A2 (SLC3A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[33]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[25]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[36]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[132]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[133]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[99]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[133]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[134]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[67]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[135]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[136]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[137]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[138]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[139]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[140]
Selenium	DM25CGV	N. A.	N. A.	Approved	[141]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[142]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[143]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[144]

Drug(s) Affected By Heat shock 70 kDa protein 1A (HSPA1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[145]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[136]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[109]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[129]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[113]
Selenium	DM25CGV	N. A.	N. A.	Approved	[33]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[146]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[147]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[121]

Drug(s) Affected By Androgen receptor (AR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[148]
Nilutamide	DMFN07X	Prostate cancer	2C82.0	Approved	[148]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[148]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[149]
Bicalutamide	DMZMSPF	Prostate cancer	2C82.0	Approved	[150]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[151]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[152]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[153]
Selenium	DM25CGV	N. A.	N. A.	Approved	[154]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[155]

Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[157]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[158]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[146]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[159]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[160]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[161]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[162]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[163]

Drug(s) Affected By Interleukin-1 receptor antagonist protein (IL1RN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[165]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[166]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[164]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[167]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[168]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[169]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[136]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[113]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[25]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[171]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[172]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[173]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[99]

Drug(s) Affected By Cyclin-dependent kinase 2 (CDK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[174]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[175]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[176]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[177]
Selenium	DM25CGV	N. A.	N. A.	Approved	[178]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[179]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[180]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[181]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[182]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[35]

Drug(s) Affected By Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[183]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[184]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[166]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[185]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[186]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[187]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[86]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[188]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]

Drug(s) Affected By Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[189]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[190]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[26]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[189]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[191]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[192]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[71]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[193]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[194]

Drug(s) Affected By Ribonucleoside-diphosphate reductase subunit M2 (RRM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[195]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[174]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[196]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[197]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[191]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]

Drug(s) Affected By DnaJ homolog subfamily A member 1 (DNAJA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[198]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[121]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[199]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[200]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[123]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[90]

Drug(s) Affected By Stress-induced-phosphoprotein 1 (STIP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[201]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[202]
Haloperidol	DM96SE0	Delirium		Approved	[203]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[204]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[71]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[203]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[203]
Mecamylamine	DMGQFYB	Essential hypertension	BA00	Approved	[204]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[205]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[136]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[206]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[109]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[207]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[157]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[113]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[159]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[208]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[196]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]

Drug(s) Affected By Receptor-type tyrosine-protein kinase FLT3 (FLT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quizartinib	DM8Y4JS	Acute myeloid leukaemia	2A60	Approved	[209]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[210]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[198]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[211]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[212]
Venetoclax	DM8I94Y	Chronic lymphocytic leukaemia	2A82.0	Approved	[213]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[214]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[215]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[216]

Drug(s) Affected By Malate dehydrogenase, mitochondrial (MDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[217]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[71]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[28]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[218]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[30]
Epigallocatechin gallate	DMCGWBJ	Hepatic fibrosis	DB93.0	Phase 3	[219]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[33]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[220]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[221]

Drug(s) Affected By Kappa-type opioid receptor (OPRK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[147]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[222]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[223]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[224]
Morphine	DMRMS0L	Advanced cancer	2A00-2F9Z	Approved	[225]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[222]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[226]
Clonidine	DM6RZ9Q	Attention deficit hyperactivity disorder	6A05.Z	Approved	[227]

Drug(s) Affected By NADP-dependent malic enzyme (ME1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[228]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[113]
Selenium	DM25CGV	N. A.	N. A.	Approved	[33]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[229]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[26]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[230]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[67]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[67]
Disulfiram	DMCL2OK	Alcohol dependence	6C40.2	Approved	[231]

Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[228]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[232]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[229]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[233]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[26]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[99]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[234]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[230]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[235]

Drug(s) Affected By Heat shock 70 kDa protein 13 (HSPA13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[201]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[236]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[237]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[71]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[238]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[239]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]

Drug(s) Affected By DNA mismatch repair protein Msh6 (MSH6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[174]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[240]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[241]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[71]

Drug(s) Affected By Ephrin-B2 (EFNB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[242]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[243]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[244]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[245]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[246]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]

Drug(s) Affected By Aldo-keto reductase family 1 member C2 (AKR1C2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[247]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[248]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[113]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[249]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[247]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[250]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[247]
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[251]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[86]

Drug(s) Affected By Protein BTG1 (BTG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[240]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[252]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[253]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[65]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[254]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[252]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[241]

Drug(s) Affected By Protein jagged-1 (JAG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[255]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[256]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[222]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[257]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[40]

Drug(s) Affected By Transcriptional activator protein Pur-alpha (PURA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[134]
Haloperidol	DM96SE0	Delirium		Approved	[203]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[71]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[246]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[258]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[30]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[90]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[259]

Drug(s) Affected By Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[203]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[198]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[260]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[260]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[261]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[260]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[44]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]

Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[262]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[247]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[248]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[247]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[247]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[172]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[263]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[122]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[247]

Drug(s) Affected By Transcription factor SOX-4 (SOX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[33]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[230]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[237]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[86]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[243]

Drug(s) Affected By Phosphatidate phosphatase LPIN1 (LPIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[33]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[61]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[44]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[62]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[45]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[26]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[264]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[83]

Drug(s) Affected By AT-rich interactive domain-containing protein 5B (ARID5B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[222]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[265]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[87]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[224]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[28]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[246]
Indomethacin	DMSC4A7	Bursitis		Approved	[266]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[267]

Drug(s) Affected By Methylsterol monooxygenase 1 (MSMO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[61]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[44]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[63]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[26]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[63]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[86]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[87]

Drug(s) Affected By Neuronal regeneration-related protein (NREP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[137]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[190]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[230]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[67]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[67]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[67]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[241]

Drug(s) Affected By Heat shock protein 105 kDa (HSPH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[121]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[133]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[99]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[38]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[268]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[123]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[269]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[71]

Drug(s) Affected By Max-binding protein MNT (MNT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[271]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[75]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[71]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[28]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[246]

Drug(s) Affected By Homeobox protein Nkx-3.1 (NKX3-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[272]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[273]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[134]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[91]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[274]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[275]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[276]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[277]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[278]

Drug(s) Affected By Cbp/p300-interacting transactivator 2 (CITED2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[222]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[230]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[86]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]

Drug(s) Affected By Growth/differentiation factor 15 (GDF15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[136]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[113]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[240]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[25]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[279]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[280]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[281]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[281]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[282]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[283]

Drug(s) Affected By Protein adenylyltransferase FICD (FICD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[28]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[29]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[27]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[91]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[32]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[259]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[284]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[285]

Drug(s) Affected By GTP-binding protein 2 (GTPBP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[65]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[237]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[83]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[286]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[47]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[29]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[27]

Drug(s) Affected By Large ribosomal subunit protein uL18m (MRPL18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[34]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[71]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[277]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[28]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[246]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[287]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[27]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[27]

Drug(s) Affected By Serine/threonine-protein kinase TAO3 (TAOK3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[71]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[288]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[289]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[90]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[290]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[91]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[32]

Drug(s) Affected By Small conductance calcium-activated potassium channel protein 2 (KCNN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[197]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Tubocurarine	DMBZIVP	Anaesthesia	9A78.6	Approved	[291]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[241]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[292]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[293]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[294]

Drug(s) Affected By Calcyclin-binding protein (CACYBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[295]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[296]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[71]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[277]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[28]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[297]

Drug(s) Affected By Myoneurin (MYNN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[241]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[224]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[30]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[79]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[221]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[284]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[298]

Drug(s) Affected By SAFB-like transcription modulator (SLTM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[221]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[284]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[74]
COUMARIN	DM0N8ZM	Discovery agent	N.A.	Investigative	[74]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[198]

Drug(s) Affected By DNA damage-inducible transcript 4 protein (DDIT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[136]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[240]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[255]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[299]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[37]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[99]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[300]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[301]

Drug(s) Affected By Oxidative stress-responsive serine-rich protein 1 (OSER1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[191]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[28]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[47]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[59]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[302]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[30]

Drug(s) Affected By DnaJ homolog subfamily B member 4 (DNAJB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[136]
Selenium	DM25CGV	N. A.	N. A.	Approved	[33]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[121]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[133]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[99]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[303]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[235]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[268]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[136]

Drug(s) Affected By Cysteine and histidine-rich domain-containing protein 1 (CHORDC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[33]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Haloperidol	DM96SE0	Delirium		Approved	[203]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[71]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[203]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[76]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[28]

Drug(s) Affected By Cystine/glutamate transporter (SLC7A11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[228]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[304]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[232]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[304]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[304]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[305]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[133]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[304]

Drug(s) Affected By Hypoxia-inducible lipid droplet-associated protein (HILPDA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[164]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[26]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[99]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[230]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[87]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[94]

Drug(s) Affected By Transcription factor MafB (MAFB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[166]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[222]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[306]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[269]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[245]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[76]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[28]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[246]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[307]

Drug(s) Affected By Sestrin-1 (SESN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[308]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[240]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[300]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[301]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[191]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[87]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[67]

Drug(s) Affected By Stress-associated endoplasmic reticulum protein 1 (SERP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[28]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[246]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[29]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[30]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[309]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[309]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[310]

Drug(s) Affected By Alpha-crystallin B chain (CRYAB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[121]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[166]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[319]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[66]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[66]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[269]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[222]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[71]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[320]

Drug(s) Affected By C-X-C motif chemokine 10 (CXCL10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[321]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[322]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[121]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[323]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[324]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[265]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]
Tofacitinib	DMBS370	Rheumatoid arthritis	FA20	Approved	[325]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[39]

Drug(s) Affected By Interleukin-6 (IL6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[164]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[326]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[327]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[137]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[328]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[139]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[318]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[329]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[330]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]

Drug(s) Affected By C-C motif chemokine 3 (CCL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[328]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[147]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[121]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[331]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[332]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[167]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[333]
Betamethasone	DMAHJEF	Acute adrenal insufficiency		Approved	[334]
Emetine	DMCT2YF	Hepatitis virus infection	1E50-1E51	Approved	[334]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[328]

Drug(s) Affected By Heat shock 70 kDa protein 6 (HSPA6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[136]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[109]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[113]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[131]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[36]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[331]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[190]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[335]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[123]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[87]

Drug(s) Affected By Prostaglandin G/H synthase 1 (PTGS1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[336]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[82]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[337]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[338]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[121]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[331]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[281]
Bupivacaine	DM4PRFC	Anaesthesia	9A78.6	Approved	[339]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[281]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[222]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 10 (TNFSF10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[207]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[98]
Selenium	DM25CGV	N. A.	N. A.	Approved	[33]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[340]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[341]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[181]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[121]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[342]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[202]

Drug(s) Affected By Cellular tumor antigen p53 (TP53)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[343]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[147]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[344]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[345]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[346]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[347]
Floxuridine	DM04LR2	Colorectal cancer	2B91.Z	Approved	[348]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[349]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[350]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[351]

Drug(s) Affected By Cytidine deaminase (CDA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[352]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[353]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[59]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[354]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[26]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[86]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[170]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[93]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[355]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[356]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[357]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[346]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[358]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[359]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[360]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[361]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[362]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[363]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[364]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[365]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[327]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[366]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[367]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[368]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[52]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[369]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[370]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[371]

Drug(s) Affected By Dihydroorotate dehydrogenase (DHODH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[190]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[372]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[71]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[28]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[373]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[84]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[302]
Atovaquone	DMY4UMW	Fungal infection	1F29-1F2F	Approved	[374]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[32]
Avastin+/-Tarceva	DMA86FL	Non-small-cell lung cancer	2C25.Y	Phase 3	[374]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[375]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[363]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[327]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[376]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[98]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[367]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[377]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[236]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[378]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[179]

Drug(s) Affected By Caspase-8 (CASP8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[379]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[380]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[381]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[382]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[383]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[52]
Selenium	DM25CGV	N. A.	N. A.	Approved	[33]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[370]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[147]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[144]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[68]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[36]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[384]
Vismodegib	DM5IXKQ	Basal cell carcinoma	2C32	Approved	[385]
Bupropion	DM5PCS7	Depression	6A70-6A7Z	Approved	[386]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[387]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[388]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[389]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[27]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[240]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[390]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[207]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[391]
Selenium	DM25CGV	N. A.	N. A.	Approved	[392]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[240]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[393]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[270]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[393]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[394]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[109]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[395]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[396]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[303]
Selenium	DM25CGV	N. A.	N. A.	Approved	[178]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[397]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[398]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[399]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[147]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[327]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[400]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[401]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[52]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[402]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[179]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[402]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[403]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[404]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[405]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[375]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[406]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[407]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[408]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[227]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[327]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[376]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[366]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[314]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[409]

Drug(s) Affected By G1/S-specific cyclin-D1 (CCND1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[410]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[411]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[409]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[412]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[104]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[377]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[413]
Selenium	DM25CGV	N. A.	N. A.	Approved	[33]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[397]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[414]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 6 (FAS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[98]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[113]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[52]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[415]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[416]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[417]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[418]
Fructose	DM43AN2	Vomiting	MD90	Approved	[419]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[98]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[133]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[420]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[421]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[349]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[409]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[422]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[423]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[424]
Selenium	DM25CGV	N. A.	N. A.	Approved	[33]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[425]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[397]

Drug(s) Affected By Catenin beta-1 (CTNNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[426]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[236]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[427]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[417]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[428]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[429]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[430]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[431]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[432]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[433]

Drug(s) Affected By Prostaglandin G/H synthase 2 (PTGS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Eicosapentaenoic acid/docosa-hexaenoic acid	DMMUCG4	Hypertriglyceridemia	5C80.1	Approved	[434]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[435]
Gamolenic acid	DMQN30Z	Allergy	4A80-4A85	Approved	[436]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[437]
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[337]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[438]
Ibandronate	DM0QZBN	Hypercalcaemia	5B91.0	Approved	[439]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[128]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[304]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[440]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 6 (FASLG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[198]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[382]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[441]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[416]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[442]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[121]
Fructose	DM43AN2	Vomiting	MD90	Approved	[419]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[443]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[444]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[445]

Drug(s) Affected By Glycogen synthase kinase-3 beta (GSK3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[156]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[446]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[447]
Selenium	DM25CGV	N. A.	N. A.	Approved	[33]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[448]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[449]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[450]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[451]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[452]

Drug(s) Affected By Heat shock factor protein 1 (HSF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[453]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[454]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[454]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[455]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[130]
Ceftazidime	DM41GRA	Bacteremia	1A73	Approved	[454]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[69]
Chlorpheniramine	DM5URA2	Allergic rhinitis	CA08.0	Approved	[454]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[454]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[454]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Interleukin-1 beta (IL1B)	TTRYK0X	IL1B_HUMAN	Suppressor	[1]
Tumor necrosis factor (TNF)	TTF8CQI	TNFA_HUMAN	Suppressor	[1]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Activator of 90 kDa heat shock protein ATPase homolog 1 (AHSA1)	OTC7AFHT	AHSA1_HUMAN	Gene/Protein Processing	[2]
Aldo-keto reductase family 1 member C1 (AKR1C1)	OTQKR4CM	AK1C1_HUMAN	Gene/Protein Processing	[2]
Aldo-keto reductase family 1 member C2 (AKR1C2)	OTQ2XMO3	AK1C2_HUMAN	Gene/Protein Processing	[2]
Alpha-crystallin B chain (CRYAB)	OTY4JGYU	CRYAB_HUMAN	Gene/Protein Processing	[3]
Amino acid transporter heavy chain SLC3A2 (SLC3A2)	OTBR33M9	4F2_HUMAN	Gene/Protein Processing	[2]
Androgen receptor (AR)	OTUBKAZZ	ANDR_HUMAN	Gene/Protein Processing	[2]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[4]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[5]
AT-rich interactive domain-containing protein 5B (ARID5B)	OTUQ4CQY	ARI5B_HUMAN	Gene/Protein Processing	[2]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Gene/Protein Processing	[2]

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