Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMI8RG1)

• Drug Name: OTX-015 Drug Info
• Synonyms: MK 8628

Indication

Disease Entry	ICD 11	Status	REF
Acute myeloid leukaemia	2A60	Phase 1/2	[1]
Myelodysplastic syndrome	2A37	Phase 1	[2]
Solid tumour/cancer	2A00-2F9Z	Phase 1	[3]

• Cross-matching ID:
  PubChem CID: 9936746
  CAS Number: CAS 202590-98-5
  TTD Drug ID: DMI8RG1

Molecule-Related Drug Atlas

Drug(s) Targeting Bromodomain-containing protein 4 (BRD4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CPI-0610	DMPXOYJ	Myelofibrosis	2A20.2	Phase 3	[5]
PLX2853	DMX168L	Acute myeloid leukaemia	2A60	Phase 1/2	[4]
RVX-208	DM1LO8K	Alzheimer disease	8A20	Phase 1/2	[5]
INCB57643	DMBGU7V	Advanced malignancy	2A00-2F9Z	Phase 1/2	[4]
ABBV-744	DMTEA9C	Acute myeloid leukaemia	2A60	Phase 1	[4]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[7]
GSK525762	DMPAWBN	Haematological malignancy	2B33.Y	Phase 1	[5]
TEN010	DM4UOY5	Advanced solid tumour	2A00-2F9Z	Phase 1	[5]
AZD5153	DMW4GM2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[4]
PMID26924192-Compound-104	DM346EU	N. A.	N. A.	Patented	[8]

Drug(s) Targeting Bromodomain and extraterminal domain protein (BET)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
CPI-0610	DMPXOYJ	Myelofibrosis	2A20.2	Phase 3	[4]
ZEN-3694	DM6VQTF	Prostate cancer	2C82.0	Phase 2	[9]
BMS-986158	DM6LDI4	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[4]
INCB054329	DM7TZL0	Refractory hematologic malignancy	2A85.5	Phase 1/2	[10]
INCB057643	DMG65CV	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[11]
ODM-207	DMOKVJD	Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[12]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[13]
GSK525762	DMPAWBN	Haematological malignancy	2B33.Y	Phase 1	[4]
PLX51107	DMXLHVW	Haematological malignancy	2B33.Y	Phase 1	[4]
BI 894999	DM7W5N2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[4]

Drug(s) Targeting Bromodomain-containing protein 2 (BRD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
ABBV-744	DMTEA9C	Acute myeloid leukaemia	2A60	Phase 1	[4]
PMID26924192-Compound-104	DM346EU	N. A.	N. A.	Patented	[8]
PMID26924192-Compound-102	DMEJ107	N. A.	N. A.	Patented	[8]
PMID26924192-Compound-103	DMWOCP7	N. A.	N. A.	Patented	[8]
PMID26924192-Compound-105	DMAWLGI	N. A.	N. A.	Patented	[8]
Pyrrolo-pyrrolone derivative 1	DMN4SE5	N. A.	N. A.	Patented	[8]
PMID26924192-Compound-106	DM9HRZJ	N. A.	N. A.	Patented	[8]
XD14	DMUMACD	Discovery agent	N.A.	Investigative	[14]
GW841819X	DMRL9IN	Discovery agent	N.A.	Investigative	[15]
PMID24000170C36	DMHUWZS	Discovery agent	N.A.	Investigative	[16]

Drug(s) Affected By Coiled-coil domain-containing protein 154 (CCDC154)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[18]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[19]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[20]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[6]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[6]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[22]

Drug(s) Affected By Sodium-dependent phosphate transport protein 3 (SLC17A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[23]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[25]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[23]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[28]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[26]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[20]

Drug(s) Affected By Protein arginine N-methyltransferase 5 (PRMT5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[30]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[28]

Drug(s) Affected By Syntaphilin (SNPH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[36]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[37]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[39]

Drug(s) Affected By Calpain-5 (CAPN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[41]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[42]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[43]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[44]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[45]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[46]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[19]

Drug(s) Affected By Prominin-1 (PROM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[47]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[48]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[49]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[50]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[36]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[52]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[53]

Drug(s) Affected By Adhesion G protein-coupled receptor B2 (ADGRB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[54]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[37]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[56]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[57]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[39]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[58]
GALLICACID	DM6Y3A0	Discovery agent	N.A.	Investigative	[59]

Drug(s) Affected By Uncharacterized protein KIAA0513 (KIAA0513)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[54]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[41]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]

Drug(s) Affected By Tetraspanin-1 (TSPAN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[18]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[66]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[67]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[68]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[6]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[39]

Drug(s) Affected By Histone H2B type 1-K (H2BC12)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[72]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[73]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[74]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[75]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[76]

Drug(s) Affected By Receptor activity-modifying protein 2 (RAMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[78]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[79]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[20]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[80]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[39]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[81]

Drug(s) Affected By 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 (PLCH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[20]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[6]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[6]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]
Milchsaure	DM462BT	Pruritus	EC90	Investigative	[82]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[83]

Drug(s) Affected By Integrin alpha-10 (ITGA10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[84]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[85]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[87]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[6]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[6]

Drug(s) Affected By Cytochrome P450 7B1 (CYP7B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[88]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[89]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[37]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[90]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[91]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[92]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[90]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[20]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[68]

Drug(s) Affected By Slit homolog 2 protein (SLIT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[93]
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[73]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[96]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[44]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[97]

Drug(s) Affected By Protein HEXIM1 (HEXIM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[98]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[99]
Piroxicam	DMTK234	Osteoarthritis	FA00-FA05	Approved	[100]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[28]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]

Drug(s) Affected By Apolipoprotein L3 (APOL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[19]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[28]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[101]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[20]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[29]

Drug(s) Affected By Protein c-Fos (FOS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[78]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[102]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[103]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[104]
Acebutolol	DM0TI4U	Hypertension	BA00-BA04	Approved	[103]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[105]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[106]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[107]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[108]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]

Drug(s) Affected By Myc proto-oncogene protein (MYC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[110]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[104]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[105]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[111]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[112]
Selenium	DM25CGV	N. A.	N. A.	Approved	[113]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[114]
Trametinib	DM2JGQ3	Melanoma	2C30	Approved	[115]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[116]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[77]

Drug(s) Affected By Erythropoietin (EPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[117]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[118]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[119]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[120]
Fenoterol	DMIP3ZV	Asthma	CA23	Approved	[121]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[122]
Enalapril	DMNFUZR	Congestive heart failure	BD10	Approved	[123]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[124]

Drug(s) Affected By Inhibin alpha chain (INHA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[70]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[125]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[126]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[127]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[20]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[6]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[6]

Drug(s) Affected By Galectin-2 (LGALS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[128]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Bortezomib	DMNO38U	Leukemia		Approved	[129]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[130]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[87]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[20]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[6]

Drug(s) Affected By Protein S100-A9 (S100A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[131]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[77]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[132]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[133]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[112]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[134]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[135]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]

Drug(s) Affected By Histone H2B type 1-J (H2BC11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[137]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[32]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[76]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[138]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[18]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[28]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Berberine	DMC5Q8X	N. A.	N. A.	Phase 4	[139]

Drug(s) Affected By Complement component C8 alpha chain (C8A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[43]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[43]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[37]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[20]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[6]

Drug(s) Affected By Glutathione S-transferase A1 (GSTA1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Artemisinin	DMOY7W3	Malaria	1F40-1F45	Approved	[140]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[141]
Thiotepa	DMIZKOP	Breast cancer	2C60-2C65	Approved	[142]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[143]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[144]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[145]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[146]
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[147]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[148]

Drug(s) Affected By Glutathione S-transferase Mu 1 (GSTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Busulfan	DMXYJ9C	Chronic myelogenous leukaemia	2A20.0	Approved	[149]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[150]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[151]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[152]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[133]
Methyldopa	DM5I621	Hypertension	BA00-BA04	Approved	[153]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[78]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[54]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[54]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[154]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[155]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[156]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[157]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[158]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[159]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[158]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[160]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[161]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[162]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[163]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[164]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[165]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[166]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[167]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[154]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[168]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[169]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[170]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[171]

Drug(s) Affected By Serine/threonine-protein kinase pim-1 (PIM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[172]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[173]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[174]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[73]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[175]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[78]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[176]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[177]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[32]

Drug(s) Affected By Glucose-6-phosphate 1-dehydrogenase (G6PD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[167]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[178]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[179]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[180]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[181]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[133]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[72]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[182]

Drug(s) Affected By Plastin-2 (LCP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[183]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Hydroxyflutamide	DMGIZF5	Prostate cancer	2C82.0	Approved	[184]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[185]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[36]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[44]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[19]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]

Drug(s) Affected By Leukemia inhibitory factor (LIF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[154]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[186]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[187]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[189]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[190]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[191]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[192]
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[193]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[194]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[195]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[48]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[196]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[197]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[198]

Drug(s) Affected By Tyrosine aminotransferase (TAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[199]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[78]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[200]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[201]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[202]
Miconazole	DMPMYE8	Cutaneous candidiasis	1F23.14	Approved	[203]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[204]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[205]

Drug(s) Affected By Interleukin-1 receptor antagonist protein (IL1RN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[206]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[207]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[206]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[128]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[208]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[209]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[210]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]

Drug(s) Affected By Glutathione hydrolase 1 proenzyme (GGT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[18]
Lidocaine	DML4ZOT	Anaesthesia	9A78.6	Approved	[167]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[174]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[36]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[211]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[212]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[213]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[167]

Drug(s) Affected By Inter-alpha-trypsin inhibitor heavy chain H1 (ITIH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[37]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[214]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[20]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[6]

Drug(s) Affected By Arachidonate 5-lipoxygenase-activating protein (ALOX5AP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[112]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[215]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[174]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[216]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[128]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[217]
Warfarin	DMJYCVW	Atrial fibrillation	BC81.3	Approved	[218]

Drug(s) Affected By Alanine--glyoxylate aminotransferase (AGXT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[205]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[26]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[20]
Fenretinide	DMRD5SP	Macular degeneration	9B78.3	Phase 3	[219]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[6]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[26]

Drug(s) Affected By Glycerol-3-phosphate dehydrogenase , cytoplasmic (GPD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[137]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[97]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[28]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[26]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[20]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[6]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[6]

Drug(s) Affected By Cathepsin S (CTSS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[220]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[220]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[221]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[36]
Bleomycin	DMNER5S	Cervical cancer	2C77.0	Approved	[220]
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[222]

Drug(s) Affected By Proteasome subunit beta type-8 (PSMB8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[93]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[187]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[223]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[224]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[35]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Sibutramine	DMFJTDI	Obesity	5B81	Approved	[225]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[18]

Drug(s) Affected By Glutathione S-transferase theta-1 (GSTT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[226]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[137]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[227]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[19]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[37]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[228]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[229]

Drug(s) Affected By RAC-alpha serine/threonine-protein kinase (AKT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Capivasertib	DM9SKW8	Breast cancer	2C60-2C65	Approved	[230]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[231]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[232]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[171]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[233]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[234]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[235]
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[236]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[114]

Drug(s) Affected By Ribonuclease 4 (RNASE4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[237]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[28]

Drug(s) Affected By Alpha-L-iduronidase (IDUA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[238]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[18]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[20]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[29]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[6]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[6]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[239]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[102]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[240]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[241]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[242]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[186]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[243]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[244]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[159]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[245]

Drug(s) Affected By Proteasome subunit beta type-10 (PSMB10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[246]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[54]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[44]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[138]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]

Drug(s) Affected By Reduced folate transporter (SLC19A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[247]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[248]
Pemetrexed	DMMX2E6	Central nervous system lymphoma	2B33.5	Approved	[248]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[249]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[249]
Atenolol	DMNKG1Z	Angina pectoris	BA40	Approved	[249]

Drug(s) Affected By Sodium- and chloride-dependent glycine transporter 1 (SLC6A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[250]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[251]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[252]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[253]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[253]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[253]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[253]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[253]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[253]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[253]

Drug(s) Affected By Mannan-binding lectin serine protease 1 (MASP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[254]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[98]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[212]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[28]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[87]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[255]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[255]

Drug(s) Affected By Aldo-keto reductase family 1 member D1 (AKR1D1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[137]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[18]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[37]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[26]

Drug(s) Affected By 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 (FUT6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[20]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[6]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[6]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[57]
3R14S-OCHRATOXIN A	DM2KEW6	Discovery agent	N.A.	Investigative	[256]

Drug(s) Affected By Ephrin-B2 (EFNB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[257]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[54]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[210]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[221]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[36]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[18]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[28]

Drug(s) Affected By Huntingtin-associated protein 1 (HAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[93]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[37]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[130]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[86]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[20]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[6]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[6]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]

Drug(s) Affected By Protein ripply3 (RIPPLY3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[258]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[258]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[36]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[258]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[259]

Drug(s) Affected By T-box transcription factor TBX4 (TBX4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[32]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[98]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[6]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[6]
SB-431542	DM0YOXQ	Pulmonary fibrosis	CB03.4	Preclinical	[260]

Drug(s) Affected By Transmembrane protease serine 3 (TMPRSS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[36]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[261]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[262]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[68]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[6]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[263]

Drug(s) Affected By Claudin-2 (CLDN2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[93]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[264]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[265]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[266]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[265]
Sanguinarine	DMDINFS	Dental plaque	DA08.4	Approved	[267]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[36]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[268]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[28]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[269]

Drug(s) Affected By Sestrin-3 (SESN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[270]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[148]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[176]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[271]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[42]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[44]

Drug(s) Affected By Inhibin beta E chain (INHBE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[272]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[273]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[272]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[272]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[272]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[43]
Erythromycin	DM4K7GQ	Acne vulgaris	ED80	Approved	[274]
Clarithromycin	DM4M1SG	Acute maxillary sinusitis		Approved	[272]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[73]

Drug(s) Affected By Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[232]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[93]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[275]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[77]
Cladribine	DM3JDRP	Hairy cell leukaemia	2A82.2	Approved	[276]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[277]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[278]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[279]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[95]

Drug(s) Affected By Histone H4 (H4C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[154]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[186]
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[280]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[148]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[281]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[183]

Drug(s) Affected By Glypican-5 (GPC5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[37]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[87]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[282]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[20]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[93]
Sulforaphane	DMQY3L0	Skin disease	EA00-EM0Z	Investigative	[83]

Drug(s) Affected By Microtubule-associated protein 1A (MAP1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[190]
Haloperidol	DM96SE0	Delirium		Approved	[178]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[178]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[44]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[283]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[284]

Drug(s) Affected By Cyclin-dependent kinase 6 (CDK6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[285]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[286]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[287]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[288]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[148]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[289]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[290]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[73]

Drug(s) Affected By Perilipin-5 (PLIN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[44]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[28]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[130]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[87]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[20]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[68]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[6]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]

Drug(s) Affected By Bcl-2-like protein 1 (BCL2L1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[232]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[291]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[157]
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[292]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[187]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[293]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[294]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[289]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[295]

Drug(s) Affected By Schlafen family member 5 (SLFN5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[296]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[297]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[36]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[98]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[298]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[28]

Drug(s) Affected By Protein mab-21-like 4 (MAB21L4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[60]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[130]
Genistein	DM0JETC	Menopause symptom	GA30.0	Phase 2/3	[229]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[68]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[6]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[299]

Drug(s) Affected By Protein disulfide-isomerase A2 (PDIA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[175]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[18]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[300]
Vitamin C	DMXJ7O8	Adenocarcinoma	2D40	Approved	[301]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[302]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[87]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[303]

Drug(s) Affected By Serine/threonine-protein kinase PAK 1 (PAK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[304]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[174]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[305]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[284]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[37]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[306]

Drug(s) Affected By Dehydrogenase/reductase SDR family member 2, mitochondrial (DHRS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[296]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[54]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[75]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[44]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[98]

Drug(s) Affected By N-myc-interactor (NMI)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[307]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[308]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[28]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[309]

Drug(s) Affected By Serine-protein kinase ATM (ATM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[310]
Paromomycin	DM1AGXN	Amoebiasis	1A36	Approved	[311]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[312]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[243]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[313]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Remdesivir	DMBFZ6L	Coronavirus Disease 2019 (COVID-19)	1D6Y	Approved	[314]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[315]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[316]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[317]

Drug(s) Affected By GRB2-related adapter protein (GRAP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[130]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[20]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[68]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[6]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[57]

Drug(s) Affected By Potassium voltage-gated channel subfamily C member 3 (KCNC3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[37]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[20]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[68]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[6]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]

Drug(s) Affected By Dihydropyrimidinase-related protein 3 (DPYSL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[93]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[318]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[319]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[253]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[253]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]

Drug(s) Affected By Lymphocyte antigen 6D (LY6D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[154]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[320]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[130]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[20]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[6]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[6]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]

Drug(s) Affected By cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (PDE3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[73]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[54]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[54]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[321]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[65]
Roflumilast	DMPGHY8	Asthma	CA23	Approved	[322]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[18]

Drug(s) Affected By Bromodomain-containing protein 3 (BRD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[174]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[323]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[174]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[324]
TAK-243	DM4GKV2	Solid tumour/cancer	2A00-2F9Z	Phase 1	[325]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[326]

Drug(s) Affected By Nuclear factor erythroid 2-related factor 2 (NFE2L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[327]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[328]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[104]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[270]
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[329]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[330]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[331]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[332]

Drug(s) Affected By Alpha-internexin (INA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[229]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[56]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[333]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[87]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[80]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[6]

Drug(s) Affected By Transcription factor NF-E2 45 kDa subunit (NFE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[174]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[334]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[32]
Aclarubicin	DMLFZHD	Acute myeloid leukaemia	2A60	Approved	[335]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[259]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[259]
Pomalidomide	DMTGBAX	Plasma cell myeloma	2A83.1	Approved	[336]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[337]

Drug(s) Affected By POU domain class 2-associating factor 1 (POU2AF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[338]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[95]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[338]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[300]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[339]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[340]

Drug(s) Affected By Histone H2B type 2-E (H2BC21)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[70]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[72]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[190]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[75]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[36]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[254]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[138]

Drug(s) Affected By Protein phosphatase 1J (PPM1J)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[29]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[65]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[18]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[37]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[229]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[323]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[87]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[73]

Drug(s) Affected By Uncharacterized protein C9orf152 (C9ORF152)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[19]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[185]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[6]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]
COUMESTROL	DM40TBU	Discovery agent	N.A.	Investigative	[263]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[75]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[341]

Drug(s) Affected By Solute carrier family 35 member F1 (SLC35F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[41]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[44]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[87]
Chlorothiazide	DMLHESP	Chronic heart failure	BD1Z	Approved	[92]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[68]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[6]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]

Drug(s) Affected By Low-density lipoprotein receptor class A domain-containing protein 1 (LDLRAD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[342]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[20]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]

Drug(s) Affected By Protein THEMIS2 (THEMIS2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[343]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[174]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[237]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[20]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[174]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[73]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[344]

Drug(s) Affected By Terminal nucleotidyltransferase 5C (TENT5C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[318]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[72]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[224]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[75]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[96]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[305]

Drug(s) Affected By FERM and PDZ domain-containing protein 2 (FRMPD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[54]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[54]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[19]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[302]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[20]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[345]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[6]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]
UNC0379	DMD1E4J	Hepatocellular carcinoma	2C12.02	Preclinical	[346]

Drug(s) Affected By Actin-binding LIM protein 2 (ABLIM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[347]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[19]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[348]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[6]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[6]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[39]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[93]

Drug(s) Affected By Protein FAM171B (FAM171B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Liothyronine	DM6IR3P	Congenital hypothyroidism		Approved	[349]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[36]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[18]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[19]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[130]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[20]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[80]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[6]

Drug(s) Affected By Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[148]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[183]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[211]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[259]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[99]

Drug(s) Affected By Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 (ENPP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Adenosine triphosphate	DM79F6G	Malnutrition	5B50-5B71	Approved	[350]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[98]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[351]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]
lysophosphatidylcholine	DMOGFVH	Discovery agent	N.A.	Investigative	[350]

Drug(s) Affected By Lipocalin-15 (LCN15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[24]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[87]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[352]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[75]

Drug(s) Affected By Lysophospholipase D GDPD3 (GDPD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[272]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[273]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[272]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[274]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[274]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[272]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[176]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[54]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[54]
Haloperidol	DM96SE0	Delirium		Approved	[274]

Drug(s) Affected By Activity-regulated cytoskeleton-associated protein (ARC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[44]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[98]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[18]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[130]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[353]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[20]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[354]

Drug(s) Affected By Armadillo-like helical domain-containing protein 4 (ARMH4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[93]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[73]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[44]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[56]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[20]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[56]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[80]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]

Drug(s) Affected By E3 ubiquitin-protein ligase TRIM50 (TRIM50)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[255]
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[255]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[6]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[6]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]
RESORCINOL	DMM37C0	Discovery agent	N.A.	Investigative	[53]

Drug(s) Affected By Organic anion transporter 7 (SLC22A9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[355]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[355]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[25]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[251]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[355]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[355]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[43]

Drug(s) Affected By Dynein regulatory complex subunit 7 (DRC7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[98]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[20]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[6]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[6]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[299]

Drug(s) Affected By E3 ubiquitin-protein ligase TRIM22 (TRIM22)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[245]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[356]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[75]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[41]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[217]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[44]

Drug(s) Affected By Heparan sulfate glucosamine 3-O-sulfotransferase 5 (HS3ST5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[51]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[56]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[20]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[56]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[303]

Drug(s) Affected By Dermatan-sulfate epimerase-like protein (DSEL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[54]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[54]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[36]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[18]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[20]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[6]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[6]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]

Drug(s) Affected By N-acetylglutamate synthase, mitochondrial (NAGS)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[44]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[18]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[205]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[20]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[56]

Drug(s) Affected By Protein mab-21-like 3 (MAB21L3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[305]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[6]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[6]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]

Drug(s) Affected By Mixed lineage kinase domain-like protein (MLKL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[357]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[358]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[359]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[43]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]

Drug(s) Affected By Arrestin domain-containing protein 4 (ARRDC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[210]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[360]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[361]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[24]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[36]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[18]

Drug(s) Affected By Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe (LFNG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[154]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[280]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[78]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[54]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[210]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]

Drug(s) Affected By Transcription factor MafA (MAFA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[18]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[20]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[68]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[6]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]
Harmine	DMPA5WD	Discovery agent	N.A.	Patented	[362]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[93]
Tributylstannanyl	DMHN7CB	Discovery agent	N.A.	Investigative	[363]

Drug(s) Affected By DEP domain-containing mTOR-interacting protein (DEPTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[93]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[73]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[364]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[36]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[321]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[97]

Drug(s) Affected By Secreted and transmembrane protein 1 (SECTM1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[183]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[54]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[54]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[253]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[262]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Lucanthone	DMZLBUO	Solid tumour/cancer	2A00-2F9Z	Approved	[365]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[20]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[56]

Drug(s) Affected By Cholesterol transporter ABCA5 (ABCA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[73]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Clorgyline	DMCEUJD	Parkinson disease	8A00.0	Approved	[366]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[367]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[368]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[19]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]

Drug(s) Affected By Neurogranin (NRGN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[188]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[56]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[323]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[56]
Nabiximols	DMHKJ5I	Cancer related pain	MG30	Phase 3	[369]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[344]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[57]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[370]

Drug(s) Affected By Liver-expressed antimicrobial peptide 2 (LEAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[347]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[43]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[201]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[28]

Drug(s) Affected By Dapper homolog 3 (DACT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[62]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[254]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[97]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[371]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[18]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[37]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]

Drug(s) Affected By Hepatitis A virus cellular receptor 1 (HAVCR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[372]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[373]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[374]
Gentamicin	DMKINJO	Bacteremia	1A73	Approved	[375]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[376]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[377]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[60]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[300]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[351]

Drug(s) Affected By Carboxypeptidase B2 (CPB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[378]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Epanova	DMHEAGL	Hypertriglyceridemia	5C80.1	Approved	[379]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[53]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Orlistat	DMRJSP8	Obesity	5B81	Approved	[380]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[348]

Drug(s) Affected By Apoptosis-inducing factor 3 (AIFM3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[20]
Camptothecin	DM6CHNJ	Solid tumour/cancer	2A00-2F9Z	Phase 3	[381]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[68]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[6]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[382]

Drug(s) Affected By Bile acid receptor (NR1H4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[23]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[383]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[384]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[385]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[357]
Nisoldipine	DM7ISKJ	Hypertension	BA00-BA04	Approved	[383]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[384]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[386]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]

Drug(s) Affected By Ghrelin O-acyltransferase (MBOAT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[20]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]

Drug(s) Affected By Endosomal/lysosomal proton channel TMEM175 (TMEM175)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[80]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[6]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[39]
THAPSIGARGIN	DMDMQIE	N. A.	N. A.	Preclinical	[387]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[93]

Drug(s) Affected By Guanine nucleotide-binding protein-like 3 (GNL3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[34]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[43]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[44]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[388]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[19]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[63]

Drug(s) Affected By Hydroxycarboxylic acid receptor 1 (HCAR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[93]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[60]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[130]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[354]

Drug(s) Affected By Keratin-associated protein 3-1 (KRTAP3-1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[26]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[20]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[6]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[6]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[26]

Drug(s) Affected By 2-aminomuconic semialdehyde dehydrogenase (ALDH8A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[389]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[390]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Racecadotril	DMFOTZ7	Diarrhea	ME05.1	Approved	[389]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[43]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[201]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[36]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[53]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[237]

Drug(s) Affected By Regulating synaptic membrane exocytosis protein 4 (RIMS4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[18]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[130]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[20]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[6]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[57]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[93]
acetaldehyde	DMJFKG4	Discovery agent	N.A.	Investigative	[341]
2-AMINO-1-METHYL-6-PHENYLIMIDAZO[4,5-B]PYRIDINE	DMNQL17	Discovery agent	N.A.	Investigative	[391]

Drug(s) Affected By Src-like-adapter 2 (SLA2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[78]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[54]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[54]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[20]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[392]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[326]

Drug(s) Affected By Protein TANC2 (TANC2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[78]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[190]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[32]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[393]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[99]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[19]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[37]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[229]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[56]

Drug(s) Affected By Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[77]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[137]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[43]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[76]

Drug(s) Affected By Ras-related protein Rab-6B (RAB6B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[40]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[55]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[18]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[351]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[323]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[6]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]

Drug(s) Affected By Cytokine-inducible SH2-containing protein (CISH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[148]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[32]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[254]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[65]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[229]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[87]

Drug(s) Affected By Transmembrane protein 74B (TMEM74B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[73]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[36]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[19]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[37]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[20]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[56]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[6]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[6]

Drug(s) Affected By Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (PAG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[60]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[31]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[394]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Benzatropine	DMF7EXL	Parkinsonian disorder		Approved	[178]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[44]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[395]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[211]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[305]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[19]

Drug(s) Affected By Rhomboid-related protein 2 (RHBDL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[69]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Sodium lauryl sulfate	DMLJ634	Constipation	DD91.1	Approved	[138]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[396]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[302]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[151]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[20]

Drug(s) Affected By Sphingomyelin phosphodiesterase 3 (SMPD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[397]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[94]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[78]
Plicamycin	DM7C8YV	Hypercalcaemia	5B91.0	Approved	[398]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[398]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[351]
Triclosan	DMZUR4N	Malaria	1F40-1F45	Approved	[87]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[20]

Drug(s) Affected By Dynein axonemal heavy chain 17 (DNAH17)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[93]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[18]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[19]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[20]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[6]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[6]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]

Drug(s) Affected By 7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase (CYP8B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Chenodiol	DMQ8JIK	Cholelithiasis	DC11	Approved	[384]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[181]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[384]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[24]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[137]
Cholic Acid	DM7OKQV	Cholelithiasis	DC11	Approved	[384]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[26]
Lindane	DMB8CNL	Infestations of lice and scabies	1G00.Z	Approved	[399]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[19]

Drug(s) Affected By Protein EFR3 homolog B (EFR3B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[259]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[259]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[237]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[400]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[401]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[20]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[402]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[6]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[403]

Drug(s) Affected By Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform (PPP2R2C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[404]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[17]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[405]
Diclofenac	DMPIHLS	Chronic renal failure	GB61.Z	Approved	[227]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[406]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[351]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[407]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[56]
Testosterone undecanoate	DMZO10Y	Hypogonadism	5A61.0	Approved	[127]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[227]

Drug(s) Affected By Ankyrin repeat and SOCS box protein 4 (ASB4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[96]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[37]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[20]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[56]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[68]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[57]

Drug(s) Affected By Choline-phosphate cytidylyltransferase B (PCYT1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[71]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[190]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[64]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[33]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[38]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[20]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[6]
Mivebresib	DMCPF90	Acute myeloid leukaemia	2A60	Phase 1	[6]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]
PMID28460551-Compound-2	DM4DOUB	N. A.	N. A.	Patented	[39]

Drug(s) Affected By Lymphatic vessel endothelial hyaluronic acid receptor 1 (LYVE1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[190]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[27]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[28]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[21]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Bromodomain and extraterminal domain protein (BET)	TTE4BSY	NOUNIPROTAC	Inhibitor	[4]
Bromodomain-containing protein 2 (BRD2)	TTDP48B	BRD2_HUMAN	Modulator	[5]
Bromodomain-containing protein 4 (BRD4)	TTRA6BO	BRD4_HUMAN	Modulator	[5]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 (PLCH2)	OTYERO80	PLCH2_HUMAN	Gene/Protein Processing	[6]
2-aminomuconic semialdehyde dehydrogenase (ALDH8A1)	OTINY3MW	AL8A1_HUMAN	Gene/Protein Processing	[6]
4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 (FUT6)	OTBZUQ7F	FUT6_HUMAN	Gene/Protein Processing	[6]
7-alpha-hydroxycholest-4-en-3-one 12-alpha-hydroxylase (CYP8B1)	OTRI4UR1	CP8B1_HUMAN	Gene/Protein Processing	[6]
Actin-binding LIM protein 2 (ABLIM2)	OT62KOXF	ABLM2_HUMAN	Gene/Protein Processing	[6]
Activity-regulated cytoskeleton-associated protein (ARC)	OTN2QQPG	ARC_HUMAN	Gene/Protein Processing	[6]
Adhesion G protein-coupled receptor B2 (ADGRB2)	OTOCY7XY	AGRB2_HUMAN	Gene/Protein Processing	[6]
Alanine--glyoxylate aminotransferase (AGXT)	OTIPTH3Q	AGT1_HUMAN	Gene/Protein Processing	[6]
Aldo-keto reductase family 1 member D1 (AKR1D1)	OTBDJ6RL	AK1D1_HUMAN	Gene/Protein Processing	[6]
Alpha-internexin (INA)	OT1D33T4	AINX_HUMAN	Gene/Protein Processing	[6]

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