Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DM2POTE)

• Drug Name: Colchicine Drug Info
• Synonyms: Colchicin; Colchicina; Colchicinum; Colchineos; Colchisol; Colchysat; Colcin; Colcrys; Colsaloid; Colstat; Condylon; Goutnil; Kolkicin; LOC; Binds to tubulin; Colchicin [German]; Colchicina [Italian]; Colchicine [JAN]; Inhibits microtubular assembly; Spindle poison; C 9754; Colchicine (TN); Colchicine, Colchicum autumnale; MPC-004; N-Acetyl trimethylcolchicinic acid methylether; Colchicine (JP15/USP); Colchicine, (R)-Isomer; Benzo(a)heptalen-9(5H)-one; Colchicine, (+-)-Isomer; N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)acetamide; N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide; N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide; N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide; N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[.alpha.]heptalen-7-yl)-acetamide; N-((7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-acetamide; (S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide; 7-alpha-H-Colchicine; 7.alpha.H-Colchicine; 7alphaH-Colchicine

Indication

Disease Entry	ICD 11	Status	REF
Acute gout flare	FA25.0	Approved	[1]
Acute gouty arthritis	FA25.0	Approved	[2]
Gout	FA25	Approved	[3]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 2	[4]
Familial Mediterranean fever		Investigative	[3]

• Therapeutic Class: Gout Suppressants
• Cross-matching ID:
  PubChem CID: 6167
  ChEBI ID: CHEBI:27882
  CAS Number: CAS 64-86-8
  TTD Drug ID: DM2POTE
  VARIDT Drug ID: DR00135
  INTEDE Drug ID: DR0372
  ACDINA Drug ID: D00149

Molecule-Related Drug Atlas

Drug(s) Targeting Tubulin (TUB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[17]
Vinorelbine	DMVXFYE	Advanced cancer	2A00-2F9Z	Approved	[18]
Cabazitaxel	DMPAZHC	Breast cancer	2C60-2C65	Approved	[19]
Ixabepilone	DM2OZ3G	Breast cancer	2C60-2C65	Approved	[19]
Eribulin	DM1DX4Q	Breast cancer	2C60-2C65	Approved	[19]
Epothilon	DMITJRU	Ovarian cancer	2C73	Phase 3	[20]
DOLASTATIN-10	DMDUV1S	Solid tumour/cancer	2A00-2F9Z	Phase 2	[21]
BMS-188797	DML1CK2	Solid tumour/cancer	2A00-2F9Z	Phase 2	[22]
Indibulin	DM6OFJ8	Advanced sarcoma	2A60-2C35	Phase 2	[23]
Soblidotin	DMO4EYX	Solid tumour/cancer	2A00-2F9Z	Phase 2	[24]

Drug(s) Transported By Multidrug resistance-associated protein 1 (ABCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[25]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[26]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[27]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[28]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[29]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[30]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[31]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[32]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[33]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[34]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[59]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[27]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[60]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[61]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[62]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[63]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[64]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[65]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[66]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[67]

Drug(s) Transported By P-glycoprotein 1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amoxicillin	DMUYNEI	Acute otitis media	AB00	Approved	[30]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[35]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[36]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[37]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[36]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[36]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[38]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[36]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[39]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[40]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[41]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[42]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[43]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[44]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[45]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[46]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[47]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[48]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[42]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[49]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[50]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[51]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[52]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[53]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[54]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[55]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[56]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[57]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[58]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[56]

Drug(s) Affected By Succinate dehydrogenase assembly factor 1, mitochondrial (SDHAF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[9]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[9]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Adenine	DMZLHKJ	Malnutrition	5B50-5B71	Approved	[9]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[70]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[71]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[72]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[73]

Drug(s) Affected By Serine/threonine-protein kinase Sgk1 (SGK1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[74]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[75]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[76]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[79]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[74]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[82]

Drug(s) Affected By E3 ubiquitin-protein ligase TRIM38 (TRIM38)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[83]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[84]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[86]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[87]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[89]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]

Drug(s) Affected By Torsin-1A (TOR1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[93]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[9]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[94]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[9]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[9]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[95]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[96]

Drug(s) Affected By Ectoderm-neural cortex protein 1 (ENC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[97]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[99]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[100]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Mifepristone	DMGZQEF	Cushing disease	5A70	Approved	[101]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[94]

Drug(s) Affected By Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[102]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[103]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[104]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Selenium	DM25CGV	N. A.	N. A.	Approved	[106]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[107]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[107]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[109]

Drug(s) Affected By Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[110]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[111]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[112]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[113]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Ibrutinib	DMHZCPO	Mantle cell lymphoma	2A85.5	Approved	[114]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[115]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[116]

Drug(s) Affected By Plexin-B2 (PLXNB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[83]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[93]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[117]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[118]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[119]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[120]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[96]
Adenine	DMZLHKJ	Malnutrition	5B50-5B71	Approved	[9]

Drug(s) Affected By Protein phosphatase 1D (PPM1D)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[121]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[123]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[124]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[125]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[126]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]

Drug(s) Affected By Regulator of G-protein signaling 16 (RGS16)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[130]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[132]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[133]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[9]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[134]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[9]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF113A (RNF113A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[135]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[9]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[9]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[9]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Adenine	DMZLHKJ	Malnutrition	5B50-5B71	Approved	[9]

Drug(s) Affected By DNA repair protein RAD51 homolog 3 (RAD51C)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[136]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[138]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[139]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[140]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[138]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[95]

Drug(s) Affected By TP53-regulated inhibitor of apoptosis 1 (TRIAP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[68]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[140]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[126]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[126]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[141]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[126]

Drug(s) Affected By Dual specificity protein phosphatase 14 (DUSP14)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[142]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[105]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[143]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[140]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[118]

Drug(s) Affected By Kinesin-like protein KIF20A (KIF20A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[121]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[144]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[139]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[139]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]

Drug(s) Affected By CUGBP Elav-like family member 2 (CELF2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[145]
Selenium	DM25CGV	N. A.	N. A.	Approved	[83]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[146]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Menthol	DMG2KW7	Back pain	ME84.Z	Approved	[147]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[72]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[148]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[96]

Drug(s) Affected By G1/S-specific cyclin-E2 (CCNE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[149]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[150]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[151]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[152]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[153]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[125]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[139]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[126]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[139]

Drug(s) Affected By Prothrombin (F2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[154]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[155]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[156]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[157]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[158]
Phytonadione	DM8HDOL	Bleeding disorder	GA20-GA21	Approved	[159]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[160]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[161]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[162]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[163]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[164]
Fructose	DM43AN2	Vomiting	MD90	Approved	[165]
Ketoprofen	DMRKXPT	Bursitis		Approved	[165]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[166]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[167]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[168]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[169]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[170]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]

Drug(s) Affected By Interleukin-1 beta (IL1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[103]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[172]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[173]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[174]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[175]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[174]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[176]
Selenium	DM25CGV	N. A.	N. A.	Approved	[177]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[178]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[179]

Drug(s) Affected By Albumin (ALB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[119]
Sulfamethoxazole	DMB08GE	Acute otitis media	AB00	Approved	[165]
Tolbutamide	DM02AWV	Advanced cancer	2A00-2F9Z	Approved	[180]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[181]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[182]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[183]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[184]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[185]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[186]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[98]

Drug(s) Affected By Glucocorticoid receptor (NR3C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[187]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[188]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Selenium	DM25CGV	N. A.	N. A.	Approved	[83]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[154]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[189]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[190]

Drug(s) Affected By Transcription factor Jun (JUN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Mitoxantrone	DMM39BF	Acute myelogenous leukaemia	2A41	Approved	[191]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]
Fructose	DM43AN2	Vomiting	MD90	Approved	[165]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[194]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[142]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[195]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[196]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[197]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[198]

Drug(s) Affected By Keratin, type I cytoskeletal 18 (KRT18)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[199]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[145]
Selenium	DM25CGV	N. A.	N. A.	Approved	[83]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[200]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[201]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[86]
Nevirapine	DM6HX9B	Human immunodeficiency virus infection	1C62	Approved	[202]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[203]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[204]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[205]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[206]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[123]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[207]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[208]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[207]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[209]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[210]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[211]

Drug(s) Affected By Interleukin-8 (CXCL8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[212]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[213]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[214]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[215]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[194]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[172]
Fexofenadine	DM17ONX	Allergic rhinitis	CA08.0	Approved	[174]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[175]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[216]
Lumiracoxib	DM1S4AG	Chronic renal failure	GB61.Z	Approved	[174]

Drug(s) Affected By Apoptosis regulator Bcl-2 (BCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[217]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[218]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[219]
Gemcitabine	DMSE3I7	Anterior urethra cancer		Approved	[220]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[165]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[204]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[221]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[222]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[167]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[223]

Drug(s) Affected By Microtubule-associated protein tau (MAPT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[224]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[225]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[226]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[227]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[131]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[228]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]

Drug(s) Affected By Endoplasmic reticulum chaperone BiP (HSPA5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[224]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[229]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[230]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[231]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[232]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[233]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[234]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[235]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[236]

Drug(s) Affected By Microtubule-associated protein 2 (MAP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[237]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[86]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[238]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[239]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[93]
Enzalutamide	DMGL19D	Prostate cancer	2C82.0	Approved	[240]

Drug(s) Affected By Cadherin-1 (CDH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[199]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[241]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[242]
Liraglutide	DM3FXPS	Non-insulin dependent diabetes	5A11	Approved	[243]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[244]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[245]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[86]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[246]

Drug(s) Affected By CD59 glycoprotein (CD59)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[103]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[247]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[139]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[93]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[248]

Drug(s) Affected By G2/mitotic-specific cyclin-B1 (CCNB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[149]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[249]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[195]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Selenium	DM25CGV	N. A.	N. A.	Approved	[250]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[251]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[208]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[252]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[144]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[253]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[254]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[188]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[169]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[171]
Selenium	DM25CGV	N. A.	N. A.	Approved	[255]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[256]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[257]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[258]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[259]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[260]

Drug(s) Affected By Tyrosine aminotransferase (TAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[261]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[262]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[263]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[264]
Miconazole	DMPMYE8	Cutaneous candidiasis	1F23.14	Approved	[265]
Azacitidine	DMTA5OE	Acute myelogenous leukaemia	2A41	Approved	[266]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[267]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[90]

Drug(s) Affected By Syndecan-1 (SDC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[98]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[268]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[131]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[93]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[269]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[270]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[271]

Drug(s) Affected By Lactoperoxidase (LPO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[272]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[272]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[272]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[272]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[148]
Sulfadiazine	DMTW3R8	Rheumatic fever	1B40-1B42	Approved	[272]
Fluorouracil	DMUM7HZ	Adenocarcinoma	2D40	Approved	[272]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[71]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[272]

Drug(s) Affected By Acetylcholinesterase (ACHE)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetylcholine	DMDF79Z	Cataract	9B10	Approved	[273]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[274]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[275]
L-Glutamic Acid	DM4PUDW	Schizophrenia	6A20	Approved	[10]
Tacrine	DM51FY6	Alzheimer disease	8A20	Approved	[276]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[277]
Neostigmine	DM6T2J3	Myasthenia gravis	8C6Y	Approved	[278]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]

Drug(s) Affected By NADPH:adrenodoxin oxidoreductase, mitochondrial (FDXR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[133]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[93]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[271]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[271]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[279]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[122]

Drug(s) Affected By Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[98]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[280]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[146]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[281]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[93]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[84]

Drug(s) Affected By NF-kappa-B inhibitor alpha (NFKBIA)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fructose	DM43AN2	Vomiting	MD90	Approved	[165]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[282]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[103]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[172]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[226]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[283]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[284]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[285]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[286]

Drug(s) Affected By M-phase inducer phosphatase 1 (CDC25A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[149]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[287]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[288]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[289]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[290]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[291]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[292]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[293]

Drug(s) Affected By GTP cyclohydrolase 1 (GCH1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[144]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[9]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[95]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[294]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[118]

Drug(s) Affected By Sodium-dependent serotonin transporter (SLC6A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Paroxetine	DM5PVQE	Anxiety disorder	6B00-6B0Z	Approved	[295]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[296]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[297]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[298]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
Aripiprazole	DM3NUMH	Bipolar I disorder		Approved	[299]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[272]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[140]
Mepyramine	DMB4SFH	Allergic rhinitis	CA08.0	Approved	[300]

Drug(s) Affected By Replication factor C subunit 1 (RFC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[135]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[301]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[302]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[9]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[9]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[118]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[119]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[96]

Drug(s) Affected By DNA damage-inducible transcript 3 protein (DDIT3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[130]
Triacetin	DM0AEPG	Onychomycosis	EE12.1	Approved	[303]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[142]
Bepridil	DM0RKS4	Chronic/stable angina	BA40.1	Approved	[104]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[229]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[304]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[144]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
Furazolidone	DM3P6V7	Diarrhea	ME05.1	Approved	[235]

Drug(s) Affected By Aryl hydrocarbon receptor (AHR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[188]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[305]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[306]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[307]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[308]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[309]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[310]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[311]
Herbimycin A	DM6YWBF	Solid tumour/cancer	2A00-2F9Z	Approved	[312]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1 (CDKN1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[153]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[313]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[195]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[314]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[315]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[251]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[316]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[208]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[317]

Drug(s) Affected By Tumor necrosis factor ligand superfamily member 9 (TNFSF9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[154]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[318]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[318]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[319]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[126]

Drug(s) Affected By Serine/threonine-protein kinase mTOR (MTOR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[320]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[321]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[322]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[323]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[324]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[325]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[326]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[327]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[328]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[272]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[329]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[330]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[331]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[332]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[333]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[334]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[335]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[336]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[337]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[282]

Drug(s) Affected By RNA-binding protein 34 (RBM34)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[162]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[9]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[9]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[338]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Cytarabine	DMZD5QR	Acute lymphoblastic leukaemia	2A85	Approved	[338]
Adenine	DMZLHKJ	Malnutrition	5B50-5B71	Approved	[9]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[71]

Drug(s) Affected By Mitogen-activated protein kinase 8 (MAPK8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[339]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[169]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[226]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[340]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[341]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[342]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[343]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[344]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[345]

Drug(s) Affected By Mitogen-activated protein kinase 9 (MAPK9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[287]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[346]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[347]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[343]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[348]
Sorbitol	DMAN0DE	Constipation	DD91.1	Approved	[349]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]

Drug(s) Affected By LIM/homeobox protein Lhx2 (LHX2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[86]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[9]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[9]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[9]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[95]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[350]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Adenine	DMZLHKJ	Malnutrition	5B50-5B71	Approved	[9]

Drug(s) Affected By DNA mismatch repair protein Msh6 (MSH6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[149]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[140]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[133]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[93]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[9]

Drug(s) Affected By RecQ-like DNA helicase BLM (BLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[149]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[139]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[133]

Drug(s) Affected By Ataxin-1 (ATXN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[145]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[196]
Selenium	DM25CGV	N. A.	N. A.	Approved	[83]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[351]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[126]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[126]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[140]

Drug(s) Affected By Caspase-9 (CASP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[352]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[353]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[204]
Mechlorethamine	DM0CVXA	Chronic myelogenous leukaemia	2A20.0	Approved	[222]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[354]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[355]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[123]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[356]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[357]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[209]

Drug(s) Affected By Interleukin-2 (IL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sirolimus	DMGW1ID	Advanced cancer	2A00-2F9Z	Approved	[165]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[358]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[359]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[360]
Naloxone	DM3FXMA	Narcotic depression	6A7Z	Approved	[361]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[362]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[363]
Fentanyl	DM8WAHT	Analgesia	MB40.8	Approved	[364]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[365]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[366]

Drug(s) Affected By Ras-related protein Rap-2b (RAP2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[108]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[9]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[9]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[95]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[119]
Adenine	DMZLHKJ	Malnutrition	5B50-5B71	Approved	[9]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[70]

Drug(s) Affected By Protein BTG1 (BTG1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[367]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[80]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[368]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[369]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[367]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[140]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[133]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[84]

Drug(s) Affected By Protein BTG2 (BTG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[370]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[371]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[157]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[261]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[125]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[369]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[139]

Drug(s) Affected By Transcription factor E2F1 (E2F1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[372]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[204]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[373]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[374]
Selenium	DM25CGV	N. A.	N. A.	Approved	[83]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[375]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[376]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[377]

Drug(s) Affected By Myelin transcription factor 1 (MYT1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[378]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[379]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[380]
Permethrin	DMZ0Q1G	Pediculus capitis infestation	1G00.0	Approved	[381]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[382]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[378]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[379]
Octanal	DMTN0OK	N. A.	N. A.	Investigative	[383]

Drug(s) Affected By DNA-binding protein inhibitor ID-3 (ID3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[215]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[74]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[384]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[154]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[385]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[386]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[74]

Drug(s) Affected By Glutamate receptor ionotropic, NMDA 1 (GRIN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[272]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[387]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[272]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[301]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[272]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[388]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[389]
Sulfadiazine	DMTW3R8	Rheumatic fever	1B40-1B42	Approved	[272]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[272]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[217]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[282]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[204]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[221]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[199]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[354]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[315]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[287]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[390]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[208]

Drug(s) Affected By Tripartite motif-containing protein 26 (TRIM26)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[261]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[9]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[94]
Diethylstilbestrol	DMN3UXQ	Gonorrheal vaginitis	GA02	Approved	[391]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[128]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[118]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[392]

Drug(s) Affected By E3 ubiquitin-protein ligase TRIM32 (TRIM32)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[93]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[9]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[9]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[95]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[392]
Adenine	DMZLHKJ	Malnutrition	5B50-5B71	Approved	[9]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[70]

Drug(s) Affected By Chromatin assembly factor 1 subunit A (CHAF1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[135]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[139]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[9]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[393]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[94]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[9]

Drug(s) Affected By Chromatin assembly factor 1 subunit B (CHAF1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[139]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[140]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[9]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[95]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[392]

Drug(s) Affected By DNA topoisomerase 3-alpha (TOP3A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[301]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[94]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[9]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Adenine	DMZLHKJ	Malnutrition	5B50-5B71	Approved	[9]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[71]
Torcetrapib	DMDHYM7	Hyperlipidaemia	5C80	Discontinued in Phase 2	[394]
Lithium chloride	DMHYLQ2	Discovery agent	N.A.	Investigative	[395]

Drug(s) Affected By Oligodendrocyte transcription factor 2 (OLIG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[92]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[272]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[350]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[350]
Sulfadiazine	DMTW3R8	Rheumatic fever	1B40-1B42	Approved	[272]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[272]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[380]
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[162]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[71]
Glyphosate	DM0AFY7	Malaria	1F40-1F45	Investigative	[272]

Drug(s) Affected By Protein BTG3 (BTG3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[157]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[9]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[396]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[9]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[9]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[95]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[397]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[148]

Drug(s) Affected By Protein-tyrosine kinase 2-beta (PTK2B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[398]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[399]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[393]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[400]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[118]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[392]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[96]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[70]
Tamibarotene	DM3G74J	T-cell leukaemia	2A90	Phase 3	[129]

Drug(s) Affected By Histone RNA hairpin-binding protein (SLBP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[145]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[237]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[137]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[9]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[401]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[9]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[9]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]

Drug(s) Affected By Nuclear factor of activated T-cells, cytoplasmic 4 (NFATC4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[86]
Vinblastine	DM5TVS3	Advanced cancer	2A00-2F9Z	Approved	[402]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[403]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[404]
Vorinostat	DMWMPD4	Adult acute monocytic leukemia		Approved	[380]
Phenylephrine	DMZHUO5	Allergic rhinitis	CA08.0	Approved	[405]
SNDX-275	DMH7W9X	Breast cancer	2C60-2C65	Phase 3	[86]
(+)-JQ1	DM1CZSJ	Testicular cancer	2C80	Phase 1	[382]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[406]

Drug(s) Affected By Neutral amino acid transporter B(0) (SLC1A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[126]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[126]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[93]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[9]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[126]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[9]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[407]

Drug(s) Affected By E3 ubiquitin-protein ligase RNF19B (RNF19B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[386]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Methylprednisolone	DM4BDON	Acute adrenal insufficiency		Approved	[386]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[133]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[408]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[386]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[95]

Drug(s) Affected By Protein MCM10 homolog (MCM10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[149]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[409]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[139]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[293]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[162]
Palbociclib	DMD7L94	Breast cancer	2C60-2C65	Approved	[410]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[9]

Drug(s) Affected By Partner and localizer of BRCA2 (PALB2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[140]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[162]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[9]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[9]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[95]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[411]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[96]
Adenine	DMZLHKJ	Malnutrition	5B50-5B71	Approved	[9]

Drug(s) Affected By E3 ubiquitin-protein ligase TRIM22 (TRIM22)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[412]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[140]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[133]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[413]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[414]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[94]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[407]

Drug(s) Affected By Leucine-rich repeat-containing protein 47 (LRRC47)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[415]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[93]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[9]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[94]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[9]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[9]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[96]
Adenine	DMZLHKJ	Malnutrition	5B50-5B71	Approved	[9]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[83]

Drug(s) Affected By Protein tyrosine phosphatase type IVA 1 (PTP4A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[416]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[89]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[68]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[133]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[72]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[63]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[389]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[119]

Drug(s) Affected By Cytochrome c oxidase assembly factor 7 (COA7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[9]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[94]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[9]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[9]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[95]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[417]

Drug(s) Affected By Mitochondrial potassium channel (CCDC51)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[140]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[9]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[9]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[9]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[95]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[417]
Adenine	DMZLHKJ	Malnutrition	5B50-5B71	Approved	[9]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[90]

Drug(s) Affected By Aurora kinase B (AURKB)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[313]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[150]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[409]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[139]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[139]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[68]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[126]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[126]

Drug(s) Affected By Integrator complex subunit 15 (INTS15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Selenium	DM25CGV	N. A.	N. A.	Approved	[83]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[9]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[94]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[9]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[9]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Adenine	DMZLHKJ	Malnutrition	5B50-5B71	Approved	[9]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[70]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[83]

Drug(s) Affected By Pleckstrin homology domain-containing family F member 1 (PLEKHF1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[252]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[94]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[418]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[419]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[420]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[96]
Adenine	DMZLHKJ	Malnutrition	5B50-5B71	Approved	[9]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[71]

Drug(s) Affected By Krueppel-like factor 6 (KLF6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[204]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[421]
Selenium	DM25CGV	N. A.	N. A.	Approved	[83]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[376]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[137]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[86]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]

Drug(s) Affected By Cell division control protein 6 homolog (CDC6)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[149]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[376]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[422]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[137]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[129]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[290]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[139]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]

Drug(s) Affected By Growth/differentiation factor 15 (GDF15)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[130]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[122]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[252]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[422]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[423]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[377]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[377]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[424]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[416]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[125]

Drug(s) Affected By Protein orai-3 (ORAI3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[126]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[9]
Rosiglitazone	DMILWZR	Chronic kidney disease	GB61	Approved	[126]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[393]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[95]

Drug(s) Affected By Protein pelota homolog (PELO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[425]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[426]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[93]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[9]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[9]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[9]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[95]

Drug(s) Affected By TIMELESS-interacting protein (TIPIN)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[140]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[228]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[9]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[427]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[9]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[9]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]

Drug(s) Affected By Angiotensin-converting enzyme 2 (ACE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Captopril	DM458UM	Chronic heart failure	BD1Z	Approved	[428]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[12]
Dantrolene	DM1D8XY	Hyperthermia	MG26	Approved	[12]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[12]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[12]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[12]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[12]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[12]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[12]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[12]

Drug(s) Affected By tRNA pseudouridine(38/39) synthase (PUS3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[140]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[9]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[94]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[9]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[9]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[95]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]

Drug(s) Affected By Transmembrane protein 185B (TMEM185B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[9]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[9]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[9]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[392]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[429]

Drug(s) Affected By Interferon-stimulated 20 kDa exonuclease-like 2 (ISG20L2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[9]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[9]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[9]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Indomethacin	DMSC4A7	Bursitis		Approved	[430]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[128]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[429]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[96]
Adenine	DMZLHKJ	Malnutrition	5B50-5B71	Approved	[9]

Drug(s) Affected By GrpE protein homolog 1, mitochondrial (GRPEL1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[431]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[146]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[93]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[9]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[9]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[9]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[95]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]

Drug(s) Affected By p53-induced death domain-containing protein 1 (PIDD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[432]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[139]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[139]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[132]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[126]
Adefovir Dipivoxil	DMMAWY1	Hepatitis B virus infection	1E51.0	Approved	[126]

Drug(s) Affected By Fructose-2,6-bisphosphatase TIGAR (TIGAR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[432]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[88]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[126]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[301]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[126]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[133]

Drug(s) Affected By DNA damage-inducible transcript 4 protein (DDIT4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[130]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[433]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[434]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[435]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[436]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[100]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[125]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]

Drug(s) Affected By Forkhead box protein J2 (FOXJ2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[78]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[140]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[9]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[9]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[9]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[96]
Adenine	DMZLHKJ	Malnutrition	5B50-5B71	Approved	[9]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[135]
bisphenol A	DM2ZLD7	Discovery agent	N.A.	Investigative	[145]

Drug(s) Affected By Homologous-pairing protein 2 homolog (PSMC3IP)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[437]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[139]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[139]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[140]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[162]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[9]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[393]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[427]

Drug(s) Affected By Protein CLN8 (CLN8)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[145]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[154]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[438]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[94]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[9]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[95]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[118]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[119]

Drug(s) Affected By rRNA methyltransferase 2, mitochondrial (MRM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[68]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[140]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[9]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[393]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[94]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[9]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[9]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[95]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[9]

Drug(s) Affected By Frizzled-1 (FZD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[91]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[261]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[89]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[140]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[127]
Mitomycin	DMH0ZJE	Breast cancer	2C60-2C65	Approved	[9]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[439]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[9]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[9]

Drug(s) Affected By SH3 and multiple ankyrin repeat domains protein 2 (SHANK2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[128]
Selenium	DM25CGV	N. A.	N. A.	Approved	[83]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[272]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[85]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[272]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Melphalan	DMOLNHF	Hematologic disease	3C0Z	Approved	[134]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[95]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[440]

Drug(s) Affected By 5'-AMP-activated protein kinase subunit beta-1 (PRKAB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[126]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[126]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[133]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[441]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[9]
Hydroxyurea	DMOQVU9	Chronic myelogenous leukaemia	2A20.0	Approved	[9]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[95]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[442]

Drug(s) Affected By Pleckstrin homology-like domain family A member 3 (PHLDA3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[81]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[68]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[90]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[126]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[133]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[126]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[94]

Drug(s) Affected By Sestrin-1 (SESN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[175]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[77]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[100]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[125]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[443]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[139]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[139]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[68]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[126]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[140]

Drug(s) Affected By RalA-binding protein 1 (RALBP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[145]
Selenium	DM25CGV	N. A.	N. A.	Approved	[83]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[135]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[327]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[95]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[444]
Dihydrotestosterone	DM3S8XC	Prostate hyperplasia	GA90	Phase 4	[240]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[70]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[83]

Drug(s) Affected By ATP-binding cassette sub-family A member 13 (ABCA13)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[69]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[94]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[440]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[445]
PMID28870136-Compound-52	DMFDERP	N. A.	N. A.	Patented	[135]
Trichostatin A	DM9C8NX	Solid tumour/cancer	2A00-2F9Z	Investigative	[446]
KOJIC ACID	DMP84CS	Discovery agent	N.A.	Investigative	[447]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Tubulin (TUB)	TTML2WA	NOUNIPROTAC	Binder	[5]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Multidrug resistance-associated protein 1 (ABCC1)	DTSYQGK	MRP1_HUMAN	Substrate	[6]
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[7]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4) Main DME	DE4LYSA	CP3A4_HUMAN	Substrate	[8]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
5'-AMP-activated protein kinase subunit beta-1 (PRKAB1)	OT1OG4QZ	AAKB1_HUMAN	Gene/Protein Processing	[9]
Acetylcholinesterase (ACHE)	OT2H8HG6	ACES_HUMAN	Gene/Protein Processing	[10]
Albumin (ALB)	OTVMM513	ALBU_HUMAN	Gene/Protein Processing	[11]
Angiotensin-converting enzyme 2 (ACE2)	OTTRZGU7	ACE2_HUMAN	Gene/Protein Processing	[12]
Apoptosis regulator BAX (BAX)	OTAW0V4V	BAX_HUMAN	Gene/Protein Processing	[13]
Apoptosis regulator Bcl-2 (BCL2)	OT9DVHC0	BCL2_HUMAN	Gene/Protein Processing	[13]
Aryl hydrocarbon receptor (AHR)	OTFE4EYE	AHR_HUMAN	Gene/Protein Processing	[14]
Ataxin-1 (ATXN1)	OTQF0HNR	ATX1_HUMAN	Gene/Protein Processing	[9]
ATP-binding cassette sub-family A member 13 (ABCA13)	OTTHTUQN	ABCAD_HUMAN	Drug Response	[15]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Gene/Protein Processing	[16]

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