Details of the Drug-Related molecule(s) Interaction Atlas

General Information of Drug (ID: DMCL2OK)

• Drug Name: Disulfiram Drug Info
• Synonyms: Abstenisil; Abstinil; Abstinyl; Alcophobin; Antabus; Antabuse; Antadix; Antaenyl; Antaethan; Antaethyl; Antaetil; Antalcol; Antetan; Antethyl; Antetil; Anteyl; Anthethyl; Antiaethan; Anticol; Antietanol; Antiethanol; Antietil; Antikol; Antivitium; Aversan; Averzan; Bonibal; Contralin; Contrapot; Cronetal; Dicupral; Disetil; Disulfan; Disulfirame; Disulfiramo; Disulfiramum; Disulfirm; Disulfram; Disulfuram; Disulphuram; Ephorran; Espenal; Esperal; Etabus; Ethyldithiourame; Ethyldithiurame; Exhoran; Exhorran; Gababentin; Hoca; Krotenal; Nocbin; Nocceler; Noxal; Refusal; Stopaethyl; Stopethyl; Stopety; Stopetyl; TATD; TETD; THIOCID; TTD; TTS; Tenurid; Tenutex; Tetidis; Tetradin; Tetradine; Tetraethylthiuram; Tetraetil; Teturam; Teturamin; Thireranide; Thiuranide; Tillram; Tiuram; Accel TET; Akrochem TETD; Ancazide ET; Antab use; Disulfirame [DCIT]; Ekagom DTET; Ekagom TEDS; Ekagom TETDS; Ekaland TETD; Esperal [France]; Eta bus; Ethyl Thiram; Ethyl Thiudad; Ethyl Thiurad; Ethyl Tuads Rodform; Ethyl Tuex; Ethyl tuads; Etyl Tuex; Nocceler TET; Perkacit TETD; Perkait TETD; Robac TET; Sanceler TET; Soxinol TET; TTS x; Tet raethylthiuram; Thiuram E; Dupon 4472; T 1132; Accel TET-R; Alk-aubs; Antabus (TN); Antabuse (TN); Anti-ethyl; Antivitium (Spain); ENT 27,340; Nocceler TET-G; Noxal (VAN); Ro-sulfiram; Sanceler TET-G; Tuads, ethyl; Usaf B-33; Ro-Sulfram-500 (USA)

Indication

Disease Entry	ICD 11	Status	REF
Alcohol dependence	6C40.2	Approved	[1]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Investigative	[2]
Middle East Respiratory Syndrome (MERS)	1D64	Investigative	[3]
Severe acute respiratory syndrome (SARS)	1D65	Investigative	[3]

• Therapeutic Class: Alcohol Deterrents
• Cross-matching ID:
  PubChem CID: 3117
  ChEBI ID: CHEBI:4659
  CAS Number: CAS 97-77-8
  TTD Drug ID: DMCL2OK
  VARIDT Drug ID: DR00310
  INTEDE Drug ID: DR0519
  ACDINA Drug ID: D00206

Molecule-Related Drug Atlas

Drug(s) Targeting MERS-CoV papain-like proteinase (PL-PRO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[14]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[14]
Mycophenolic acid	DMRBMAU	Crohn disease	DD70	Approved	[15]
PMID30940566-compound-6	DMXCKL9	Middle East Respiratory Syndrome (MERS)	1D64	Preclinical	[16]

Drug(s) Targeting Fatty aldehyde dehydrogenase (ALDH3A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
NPS 1776	DM0CF3B	Epilepsy	8A60-8A68	Discontinued in Phase 2	[17]
NSC-527035	DMY689Z	Discovery agent	N.A.	Investigative	[18]
Aloe-emodin	DMPTY8S	Discovery agent	N.A.	Investigative	[19]
S-methyl 4-methyl-4-morpholinopent-2-ynethioate	DM79QC2	Discovery agent	N.A.	Investigative	[20]

Drug(s) Targeting COVID-19 papain-like proteinase (PL-PRO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[21]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[2]
PX-12	DMLVHAJ	Pancreatic cancer	2C10	Phase 2	[2]
Tideglusib	DME4LA1	Alzheimer disease	8A20	Phase 2	[2]
Hexylcarbamoyl fluorouracil	DMYNPK8	Solid tumour/cancer	2A00-2F9Z	Withdrawn from market	[2]
PMID26868298-compound-N3	DMQFUCD	Middle East Respiratory Syndrome (MERS)	1D64	Preclinical	[2]
GRL0617	DMX9AGF	Coronavirus infection	1D92	Preclinical	[22]
Isoarnebin 4	DM0B7NO	Coronavirus Disease 2019 (COVID-19)	1D6Y	Investigative	[2]
PMID32321856-compound-11a	DMN39V6	Coronavirus Disease 2019 (COVID-19)	1D6Y	Investigative	[23]
PMID32321856-compound-11b	DM31QEY	Coronavirus Disease 2019 (COVID-19)	1D6Y	Investigative	[23]

Drug(s) Targeting SARS-CoV papain-like proteinase (PL-PRO)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Thioguanine	DM7NKEV	Acute lymphocytic leukaemia	2B33.3	Approved	[14]
Mercaptopurine	DMTM2IK	Acute lymphoblastic leukaemia	2A85	Approved	[14]
GRL-0667	DML09OS	Severe acute respiratory syndrome (SARS)	1D65	Investigative	[24]
PMID20527968-compound-6577871	DMI30V7	Severe acute respiratory syndrome (SARS)	1D65	Investigative	[24]

Drug(s) Metabolized By Cytochrome P450 3A4 (CYP3A4)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[25]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[26]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[27]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[28]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[29]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[30]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[31]
Zidovudine	DM4KI7O	Human immunodeficiency virus infection	1C62	Approved	[32]
Prasterone	DM67VKL	Chronic obstructive pulmonary disease	CA22	Approved	[26]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[33]
Eplerenone	DMF0NQR	Heart failure	BD10-BD13	Approved	[431]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[432]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[433]
Voriconazole	DMAOL2S	Aspergillosis	1F20	Approved	[434]
Proguanil	DMBL79I	Malaria	1F40-1F45	Approved	[435]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[435]
Loratadine	DMF3AN7	Allergy	4A80-4A85	Approved	[436]
Nelfinavir mesylate	DMFX6G8	N. A.	N. A.	Approved	[437]
Capsaicin	DMGMF6V	Back pain	ME84.Z	Approved	[438]
Axitinib	DMGVH6N	Renal cell carcinoma	2C90	Approved	[439]

Drug(s) Metabolized By Cytochrome P450 3A5 (CYP3A5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[34]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[35]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[36]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[37]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[38]
Sulfasalazine	DMICA9H	Irritable bowel syndrome	DD91.0	Approved	[39]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[40]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[41]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[42]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[37]

Drug(s) Metabolized By Cytochrome P450 2E1 (CYP2E1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[43]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[44]
Tamoxifen	DMLB0EZ	Breast cancer	2C60-2C65	Approved	[45]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[46]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[47]
Oxaliplatin	DMQNWRD	Adenocarcinoma	2D40	Approved	[48]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[49]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[50]
Propofol	DMB4OLE	Anaesthesia	9A78.6	Approved	[51]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[52]
Fomepizole	DM6VOWQ	Athylene glycol or methanol poisoning	NE61	Approved	[70]
Ademetionine	DMYQDBO	Hepatic fibrosis	DB93.0	Approved	[71]
Theophylline	DMRJFN9	Bronchitis	CA20	Approved	[72]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[73]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[74]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[75]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Didanosine	DMI2QPE	Human immunodeficiency virus infection	1C62	Approved	[72]
Thioridazine	DM35M8J	Schizophrenia	6A20	Approved	[76]

Drug(s) Affected By Retinaldehyde dehydrogenase 3 (ALDH1A3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[55]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[56]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[57]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[59]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[59]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[60]

Drug(s) Affected By Dopamine beta-hydroxylase (DBH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Levodopa	DMN3E57	Parkinson disease	8A00.0	Approved	[63]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Bromocriptine	DMVE3TK	Acromegaly	5A60.0	Approved	[63]
Nicotine	DMWX5CO	Lung cancer	2C25.0	Approved	[65]
Artesunate	DMR27C8	Infection of P. falciparum	1F40	Approved	[66]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[67]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[68]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[69]

Drug(s) Affected By Multidrug resistance-associated protein 1 (ABCC1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[77]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[78]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[79]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[80]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[81]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[82]
Epirubicin	DMPDW6T	Solid tumour/cancer	2A00-2F9Z	Approved	[83]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[84]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[85]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[85]

Drug(s) Affected By Metallothionein-2 (MT2A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[86]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[87]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[89]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[90]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[91]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[92]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[94]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[59]

Drug(s) Affected By Metallothionein-1F (MT1F)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[87]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[95]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[92]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[99]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[100]
Niclosamide	DMJAGXQ	Cestodes infection	1F70-1F76	Approved	[101]

Drug(s) Affected By Metallothionein-1B (MT1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[102]
Promegestone	DMK4S8I	Gynecological disease	GA6Z	Approved	[103]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[104]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[105]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[106]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[107]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[108]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[109]
Malathion	DMXZ84M	Pediculus capitis infestation	1G00.0	Approved	[110]

Drug(s) Affected By Metallothionein-1G (MT1G)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[111]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[92]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[113]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Motexafin gadolinium	DMEJKRF	Brain cancer	2A00	Approved	[100]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[115]

Drug(s) Affected By DNA replication licensing factor MCM5 (MCM5)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[116]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[117]
Selenium	DM25CGV	N. A.	N. A.	Approved	[118]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[119]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[120]
Chlorpromazine	DMBGZI3	Acute intermittent hepatic porphyria	5C58.11	Approved	[121]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[56]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]

Drug(s) Affected By DNA replication licensing factor MCM2 (MCM2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[87]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[122]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[119]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[120]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[123]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[124]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[125]

Drug(s) Affected By Metallothionein-1X (MT1X)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[111]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[126]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[92]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[93]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]

Drug(s) Affected By Transcription factor MafG (MAFG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[128]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[59]

Drug(s) Affected By Aldo-keto reductase family 1 member B10 (AKR1B10)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[117]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[129]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Rifampicin	DM5DSFZ	Non-insulin dependent diabetes	5A11	Approved	[131]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[132]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[133]
Reserpine	DM6VM38	Hypertension	BA00-BA04	Approved	[134]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[135]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]

Drug(s) Affected By Transcription factor MafK (MAFK)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[128]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[136]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[137]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[64]
Phenobarbital	DMXZOCG	Cluster headache	8A81.0	Approved	[139]
Urethane	DM7NSI0	N. A.	N. A.	Phase 4	[69]
DNCB	DMDTVYC	Immune System disease	4A01-4B41	Phase 2	[140]

Drug(s) Affected By Glutathione reductase, mitochondrial (GSR)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[141]
Ketoprofen	DMRKXPT	Bursitis		Approved	[72]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[142]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[143]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[129]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[144]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[145]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[146]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[92]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[147]

Drug(s) Affected By Superoxide dismutase (SOD1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[148]
Haloperidol	DM96SE0	Delirium		Approved	[72]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[149]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[150]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[151]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[152]
SPI-1005	DM6XFHS	Reperfusion injury	ND56.Z	Approved	[153]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[154]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[155]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[156]

Drug(s) Affected By Ferritin light chain (FTL)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Selenium	DM25CGV	N. A.	N. A.	Approved	[118]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[157]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[158]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[159]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[124]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[160]
Folic Acid	DMEMBJC	Colorectal carcinoma		Approved	[161]

Drug(s) Affected By Superoxide dismutase , mitochondrial (SOD2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[162]
Selenium	DM25CGV	N. A.	N. A.	Approved	[163]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[164]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[165]
Epinephrine	DM3KJBC	Acute asthma	CA23	Approved	[155]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[166]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[167]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[145]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[168]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[120]

Drug(s) Affected By Extracellular superoxide dismutase (SOD3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[169]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[170]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[171]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[172]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[173]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[115]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[141]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[174]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[175]

Drug(s) Affected By Heme oxygenase 1 (HMOX1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[176]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[111]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[177]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[178]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[179]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[162]
Selenium	DM25CGV	N. A.	N. A.	Approved	[180]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[181]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[182]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[169]

Drug(s) Affected By Heat shock 70 kDa protein 1A (HSPA1A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Carbamazepine	DMZOLBI	Epilepsy	8A60-8A68	Approved	[183]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[111]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[184]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[185]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Selenium	DM25CGV	N. A.	N. A.	Approved	[118]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[186]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[187]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[91]

Drug(s) Affected By Microsomal glutathione S-transferase 1 (MGST1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[188]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[189]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[57]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[190]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[124]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[191]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[115]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[104]

Drug(s) Affected By Glucose-6-phosphate 1-dehydrogenase (G6PD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[72]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[193]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[194]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[143]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[129]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[195]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[196]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[197]

Drug(s) Affected By Aldo-keto reductase family 1 member B1 (AKR1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[95]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[198]
Glutathione	DMAHMT9	Human immunodeficiency virus infection	1C62	Approved	[199]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[190]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[124]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[115]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[9]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[200]

Drug(s) Affected By NAD(P)H dehydrogenase 1 (NQO1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[59]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[201]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[151]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[202]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[203]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[204]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[165]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[205]
Rofecoxib	DM3P5DA	Osteoarthritis	FA00-FA05	Approved	[167]

Drug(s) Affected By Glutathione peroxidase 3 (GPX3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Selenium	DM25CGV	N. A.	N. A.	Approved	[118]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[145]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[196]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[206]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[207]
Pioglitazone	DMKJ485	Amyotrophic lateral sclerosis	8B60.0	Approved	[208]

Drug(s) Affected By Ferrochelatase, mitochondrial (FECH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[209]
Selenium	DM25CGV	N. A.	N. A.	Approved	[118]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[210]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[59]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[59]
Zoledronate	DMIXC7G	Adenocarcinoma	2D40	Approved	[115]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[9]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[200]

Drug(s) Affected By Aldo-keto reductase family 1 member C3 (AKR1C3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[175]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[211]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[212]
Levonorgestrel	DM1DP7T	Atypical endometrial hyperplasia		Approved	[213]
Desogestrel	DM27U4Y	Contraception	QA21	Approved	[213]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[211]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[211]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[214]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[215]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]

Drug(s) Affected By NADP-dependent malic enzyme (ME1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Selenium	DM25CGV	N. A.	N. A.	Approved	[118]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[129]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[95]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[196]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[113]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[59]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[59]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[216]

Drug(s) Affected By Glutamate--cysteine ligase catalytic subunit (GCLC)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[162]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[188]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[129]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[217]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[218]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[119]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[95]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[219]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[220]

Drug(s) Affected By Glutamate--cysteine ligase regulatory subunit (GCLM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[221]
Clavulanate	DM2FGRT	Bacteremia	1A73	Approved	[129]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[222]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[95]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[196]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[92]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[223]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[113]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[224]

Drug(s) Affected By 6-phosphogluconate dehydrogenase, decarboxylating (PGD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[171]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[196]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[159]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[124]
Methylene blue	DMJAPE7	Acquired methemoglobinemia	3A93	Approved	[225]
Benzoic Acid	DMKB9FI	Alopecia areata	ED70.2	Approved	[9]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[200]

Drug(s) Affected By Aldo-keto reductase family 1 member C1 (AKR1C1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[226]
Meclofenamic acid	DM05FXR	Ankylosing spondylitis	FA92.0	Approved	[211]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[212]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[227]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[211]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[211]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[228]
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[229]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[227]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[211]

Drug(s) Affected By Prostaglandin reductase 1 (PTGR1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[117]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[95]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[159]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[230]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[98]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[124]
Ampicillin	DMHWE7P	Acute epiglottitis		Approved	[112]

Drug(s) Affected By SPRY domain-containing SOCS box protein 1 (SPSB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[95]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[135]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ifosfamide	DMCT3I8	Adult central nervous system germ cell tumor		Approved	[59]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[200]
Azathioprine	DMMZSXQ	Lupus nephritis	4A40.0Y	Approved	[231]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[137]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[59]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[232]

Drug(s) Affected By Sulfiredoxin-1 (SRXN1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[106]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[119]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[61]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[132]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[233]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[234]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[59]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[59]

Drug(s) Affected By Transcription factor MafF (MAFF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[127]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[194]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[106]
Salicyclic acid	DM2F8XZ	Acne vulgaris	ED80	Approved	[235]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
obeticholic acid	DM3Q1SM	Primary biliary cholangitis	DB96.1	Approved	[145]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[119]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[196]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[128]

Drug(s) Affected By Retinal dehydrogenase 2 (ALDH1A2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[236]
Polyethylene glycol	DM4I1JP	Constipation	DD91.1	Approved	[236]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[236]
Panobinostat	DM58WKG	Chronic graft versus host disease		Approved	[55]
Thalidomide	DM70BU5	Adult T-cell leukemia/lymphoma		Approved	[236]
Nilotinib	DM7HXWT	Chronic myelogenous leukaemia	2A20.0	Approved	[236]
Ramelteon	DM7IW9J	Insomnia	7A00-7A0Z	Approved	[236]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Dabigatran	DMDI6R4	Stroke	8B20	Approved	[236]
Metoclopramide	DMFA5MY	Nausea	MD90	Approved	[236]

Drug(s) Affected By Aldehyde dehydrogenase, mitochondrial (ALDH2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[237]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[95]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[238]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[189]
Imatinib	DM7RJXL	Acute lymphoblastic leukaemia	2A85	Approved	[239]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[124]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[240]

Drug(s) Affected By 11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[241]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[117]
Testosterone	DM7HUNW	Hot flushes	GA30	Approved	[58]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[58]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[190]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[242]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[243]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[244]
Oxymetholone	DMFXUT8	Aplastic anemia	3A70	Approved	[245]
Hydrocortisone	DMGEMB7	Acne vulgaris	ED80	Approved	[246]

Drug(s) Affected By Bile salt export pump (ABCB11)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Glimepiride	DM5FSJA	Diabetic complication	5A2Y	Approved	[247]
Ezetimibe	DM7A8TW	Atherosclerosis	BD40	Approved	[248]
Glipizide	DMZA5PQ	Diabetic complication	5A2Y	Approved	[248]
Bosentan	DMIOGBU	Pulmonary arterial hypertension	BB01.0	Approved	[191]
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[247]
Ofloxacin	DM0VQN3	Acute gonococcal cervicitis		Approved	[248]
Primidone	DM0WX6I	Epilepsy	8A60-8A68	Approved	[249]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[247]
Drospirenone	DM1A9W3	Acne vulgaris	ED80	Approved	[250]
Nitrendipine	DM21C09	Hypertension	BA00-BA04	Approved	[247]

Drug(s) Affected By Aldehyde dehydrogenase 1A1 (ALDH1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[106]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[251]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[252]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[253]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[238]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[172]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[254]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[216]

Drug(s) Affected By Transforming growth factor beta-1 proprotein (TGFB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[255]
Gabapentin	DM6T924	Complex partial seizure	8A68.0	Approved	[72]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[256]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[257]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[258]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[259]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[260]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[261]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[262]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[187]

Drug(s) Affected By Tumor necrosis factor (TNF)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[263]
Amphotericin B	DMTAJQE	Acne vulgaris	ED80	Approved	[264]
Fructose	DM43AN2	Vomiting	MD90	Approved	[72]
Ketoprofen	DMRKXPT	Bursitis		Approved	[72]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[265]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[266]
Baclofen	DM0QV1J	Multiple sclerosis	8A40	Approved	[267]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[268]
Ganciclovir	DM1MBYQ	Cytomegalovirus infection	1D82	Approved	[269]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[270]

Drug(s) Affected By Catalase (CAT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[151]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[271]
Haloperidol	DM96SE0	Delirium		Approved	[72]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[142]
Selenium	DM25CGV	N. A.	N. A.	Approved	[272]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[273]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[274]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[187]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[275]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]

Drug(s) Affected By Cytochrome P450 1A1 (CYP1A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[276]
Riluzole	DMECBWN	Amyotrophic lateral sclerosis	8B60.0	Approved	[277]
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[278]
Menadione	DMSJDTY	Vitamin K deficiency	5B59	Approved	[279]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[280]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[91]
Ethacrynic acid	DM60QMR	Edema	MG29	Approved	[227]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[281]
Ethinyl Estradiol	DMODJ40	Acne vulgaris	ED80	Approved	[282]
Clofibrate	DMPC1J7	Dysbetalipoproteinemia	5C80.2	Approved	[283]

Drug(s) Affected By ATP-dependent translocase ABCB1 (ABCB1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flupentixol	DM0DJ9O	Schizophrenia	6A20	Approved	[284]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[285]
Crizotinib	DM4F29C	Non-small-cell lung cancer	2C25.Y	Approved	[286]
Lamotrigine	DM8SXYG	Bipolar disorder	6A60	Approved	[287]
Cepharanthine	DM9Y5JB	N. A.	N. A.	Approved	[288]
Itraconazole	DMCR1MV	Aspergillosis	1F20	Approved	[289]
Clozapine	DMFC71L	Schizophrenia	6A20	Approved	[290]
Midostaurin	DMI6E0R	Acute myeloid leukaemia	2A60	Approved	[291]
Trifluoperazine	DMKBYWI	Anxiety		Approved	[292]
Olanzapine	DMPFN6Y	Bipolar depression		Approved	[290]

Drug(s) Affected By 72 kDa type IV collagenase (MMP2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[293]
Selenium	DM25CGV	N. A.	N. A.	Approved	[294]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[295]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[296]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[297]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[298]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[196]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[299]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[300]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[301]

Drug(s) Affected By Poly polymerase 1 (PARP1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[87]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[302]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[303]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[304]
Citalopram	DM2G9AE	Acute coronary syndrome	BA41	Approved	[305]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[306]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[305]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[307]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[308]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[309]

Drug(s) Affected By Integrin alpha-M (ITGAM)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indomethacin	DMSC4A7	Bursitis		Approved	[310]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[171]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[311]
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[312]
Atorvastatin	DMF28YC	Acute coronary syndrome	BA41	Approved	[313]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[99]
Cholecalciferol	DMGU74E	Adult acute monocytic leukemia		Approved	[314]
Dasatinib	DMJV2EK	Blast phase chronic myelogenous leukemia, BCR-ABL1 positive		Approved	[315]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[316]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]

Drug(s) Affected By C-C motif chemokine 2 (CCL2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Indinavir	DM0T3YH	Human immunodeficiency virus infection	1C62	Approved	[317]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[194]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[318]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[270]
Imiquimod	DM1TMA3	Alopecia areata	ED70.2	Approved	[259]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[319]
TECFIDERA	DM2OVDT	Multiple sclerosis	8A40	Approved	[181]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[187]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[320]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[321]

Drug(s) Affected By Matrix metalloproteinase-9 (MMP9)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[322]
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[194]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[268]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[270]
Selenium	DM25CGV	N. A.	N. A.	Approved	[294]
Pentosan Polysulfate	DM2HRKE	Interstitial cystitis	GC00.3	Approved	[323]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[307]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[324]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[325]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[326]

Drug(s) Affected By Histone H2AX (H2AX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[327]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[328]
Selenium	DM25CGV	N. A.	N. A.	Approved	[118]
Ribavirin	DMEYLH9	Hepatitis C virus infection	1E51.1	Approved	[329]
Etretinate	DM2CZFA	Keratosis	ED56	Approved	[330]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[331]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[332]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[333]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[334]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[335]

Drug(s) Affected By Methylated-DNA--protein-cysteine methyltransferase (MGMT)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
DTI-015	DMXZRW0	Brain cancer	2A00	Approved	[336]
Cyclophosphamide	DM4O2Z7	Advanced cancer	2A00-2F9Z	Approved	[238]
Acocantherin	DM7JT24	Atrial fibrillation	BC81.3	Approved	[337]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[124]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[338]
Phenytoin	DMNOKBV	Epilepsy	8A60-8A68	Approved	[339]
Dacarbazine	DMNPZL4	Adenocarcinoma	2D40	Approved	[340]
Topotecan	DMP6G8T	Central nervous system neoplasm		Approved	[341]
Irinotecan	DMP6SC2	Adenocarcinoma	2D40	Approved	[341]

Drug(s) Affected By Platelet glycoprotein 4 (CD36)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[342]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[343]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[95]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[344]
Tolcapone	DM8MNVO	Parkinson disease	8A00.0	Approved	[345]
Ibuprofen	DM8VCBE	Dysmenorrhea	GA34.3	Approved	[346]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[190]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[216]
Asasantin	DMCZIHT	Cerebrovascular ischaemia	8B1Z	Approved	[347]
Fenofibrate	DMFKXDY	Coronary atherosclerosis		Approved	[130]

Drug(s) Affected By Cyclic AMP-dependent transcription factor ATF-3 (ATF3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[111]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[348]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[349]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[228]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[89]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[130]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[95]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[92]

Drug(s) Affected By Cystathionine gamma-lyase (CTH)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[111]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[350]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[95]
Isotretinoin	DM4QTBN	Acne vulgaris	ED80	Approved	[196]
Acetic Acid, Glacial	DM4SJ5Y	infection in the ear canal	AA0Y	Approved	[92]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[220]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[133]
Marinol	DM70IK5	Anorexia nervosa cachexia	6B80	Approved	[111]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Clodronate	DM9Y6X7	Hypercalcaemia	5B91.0	Approved	[59]

Drug(s) Affected By Peroxisome proliferator-activated receptor gamma (PPARG)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[351]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[352]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[353]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[354]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[54]
Glucosamine	DM4ZLFD	Osteoarthritis	FA00-FA05	Approved	[355]
Isoniazid	DM5JVS3	Latent tuberculosis infection		Approved	[356]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[357]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[358]
Stavudine	DM6DEK9	Human immunodeficiency virus infection	1C62	Approved	[359]

Drug(s) Affected By C-C chemokine receptor type 2 (CCR2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[360]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[361]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[362]
Nefazodone	DM4ZS8M	Major depressive disorder	6A70.3	Approved	[128]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Ethanol	DMDRQZU	Chronic pain	MG30	Approved	[363]
Alitretinoin	DMME8LH	Kaposi sarcoma	2B57	Approved	[364]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[365]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[366]
Arsenic	DMTL2Y1	N. A.	N. A.	Approved	[367]

Drug(s) Affected By Caspase-3 (CASP3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[368]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[369]
Lovastatin	DM9OZWQ	Arteriosclerosis	BD40	Approved	[370]
Cidofovir	DMA13GD	Cytomegalovirus infection	1D82	Approved	[371]
Docetaxel	DMDI269	Advanced cancer	2A00-2F9Z	Approved	[372]
Etoposide	DMNH3PG	Acute myelogenous leukaemia	2A41	Approved	[373]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[374]
Mannitol	DMSCDY9	Bronchiectasis	CA24	Approved	[375]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[376]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[377]

Drug(s) Affected By Cyclin-dependent kinase inhibitor 1B (CDKN1B)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Fulvestrant	DM0YZC6	Breast cancer	2C60-2C65	Approved	[378]
Gefitinib	DM15F0X	Colon adenocarcinoma		Approved	[379]
Prednisone	DM2HG4X	Acute asthma	CA23	Approved	[380]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[381]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[382]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[383]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[384]
Fluoxetine	DM3PD2C	Bipolar depression		Approved	[385]
Troglitazone	DM3VFPD	Diabetic complication	5A2Y	Approved	[386]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[387]

Drug(s) Affected By Caspase-7 (CASP7)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[322]
Sertraline	DM0FB1J	Coronary heart disease	BA80.Z	Approved	[184]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[388]
Nitric Oxide	DM1RBYG	Hypertension	BA00-BA04	Approved	[389]
Spironolactone	DM2AQ5N	Chronic heart failure	BD1Z	Approved	[390]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[390]
Methotrexate	DM2TEOL	Anterior urethra cancer		Approved	[169]
Dactinomycin	DM2YGNW	Adult kidney Wilms tumor		Approved	[391]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[392]
Lapatinib	DM3BH1Y	Breast cancer	2C60-2C65	Approved	[334]

Drug(s) Affected By Gasdermin-D (GSDMD)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[265]
Romiplostim	DM3U7SZ	Thrombocytopenia	3B64	Approved	[393]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[394]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Ivermectin	DMDBX5F	Intestinal strongyloidiasis due to nematode parasite	1F6B	Approved	[124]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[200]
Sorafenib	DMS8IFC	Adenocarcinoma	2D40	Approved	[393]
Ropivacaine	DMSPJG2	Anaesthesia	9A78.6	Approved	[395]
Paclitaxel	DMLB81S	Breast carcinoma		Approved	[396]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[397]

Drug(s) Affected By Hemoglobin subunit gamma-2 (HBG2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[398]
Aspirin	DM672AH	Acute coronary syndrome	BA41	Approved	[399]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[190]
Testosterone enanthate	DMB6871	N. A.	N. A.	Approved	[60]
Primaquine	DMWQ16I	Malaria	1F40-1F45	Approved	[400]
Resveratrol	DM3RWXL	Giant cell arteritis	4A44.2	Phase 3	[401]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[402]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[397]
Butanoic Acid	DMTAJP7	Discovery agent	N.A.	Investigative	[403]

Drug(s) Affected By Apoptosis regulator BAX (BAX)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Sevoflurane	DMC9O43	Anaesthesia	9A78.6	Approved	[404]
Aprepitant	DM053KT	Depression	6A70-6A7Z	Approved	[377]
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[87]
Verapamil	DMA7PEW	Angina pectoris	BA40	Approved	[405]
Beta-carotene	DM0RXBT	Vitamin deficiency	5B55-5B71	Approved	[149]
Leuprorelin acetate	DM15HAT	Prostate cancer	2C82.0	Approved	[406]
Talazoparib	DM1KS78	Breast cancer	2C60-2C65	Approved	[407]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[209]
Meloxicam	DM2AR7L	Arthritis	FA20	Approved	[408]
Ciprofloxacin XR	DM2NLS9	Acute gonococcal cervicitis		Approved	[306]

Drug(s) Affected By Cytochrome P450 1B1 (CYP1B1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Flutamide	DMK0O7U	Prostate cancer	2C82.0	Approved	[277]
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[88]
Estradiol	DMUNTE3	Acne vulgaris	ED80	Approved	[409]
Progesterone	DMUY35B	Amenorrhea	GA20.0	Approved	[109]
Estrone	DM5T6US	Acne vulgaris	ED80	Approved	[410]
Melatonin	DMKWFBT	Depression	6A70-6A7Z	Approved	[411]
Vitamin A	DMJ2AH4	Night blindness	9D45	Approved	[412]
Amodiaquine	DME4RA8	Malaria	1F40-1F45	Approved	[413]
Daunorubicin	DMQUSBT	Acute monocytic leukemia		Approved	[414]
Pantothenic acid	DM091H2	Vitamin deficiency	5B55-5B71	Approved	[177]

Drug(s) Affected By Scavenger receptor cysteine-rich type 1 protein M130 (CD163)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Calcitriol	DM8ZVJ7	Congenital alopecia	LC30	Approved	[173]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[135]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Valsartan	DMREUQ6	Chronic heart failure	BD1Z	Approved	[415]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[416]
CHOLINE	DM5D9YK	Insomnia	7A00-7A0Z	Investigative	[417]

Drug(s) Affected By Metallothionein-1M (MT1M)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Cannabidiol	DM0659E	Dravet syndrome	8A61.11	Approved	[111]
Deoxycholic acid	DM3GYAL	Subcutaneous fat disorder	EF02	Approved	[89]
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[418]
Phenoxybenzamine	DM8KSQH	Malignant essential hypertension	BA00	Approved	[89]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[62]
Dexamethasone	DMMWZET	Acute adrenal insufficiency		Approved	[104]
Amiodarone	DMUTEX3	Tachyarrhythmias	BC71	Approved	[419]

Drug(s) Affected By C-type lectin domain family 7 member A (CLEC7A)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[120]
Arsenic trioxide	DM61TA4	Acute lymphoblastic leukaemia	2A85	Approved	[113]
Bortezomib	DMNO38U	Leukemia		Approved	[420]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Acetaminophen	DMUIE76	Allergic rhinitis	CA08.0	Approved	[192]
Benzo(a)pyrene	DMN7J43	N. A.	N. A.	Phase 1	[397]
Beta-D-Glucose	DM5IHYP	Discovery agent	N.A.	Investigative	[421]
Formaldehyde	DM7Q6M0	Discovery agent	N.A.	Investigative	[422]
paraquat	DMR8O3X	Discovery agent	N.A.	Investigative	[423]
Butanoic Acid	DMTAJP7	Discovery agent	N.A.	Investigative	[424]

Drug(s) Affected By Angiotensin-converting enzyme 2 (ACE2)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Captopril	DM458UM	Chronic heart failure	BD1Z	Approved	[425]
Diazepam	DM08E9O	Alcohol withdrawal		Approved	[426]
Dantrolene	DM1D8XY	Hyperthermia	MG26	Approved	[426]
Methimazole	DM25FL8	Hyperthyroidism	5A02	Approved	[426]
Imipramine	DM2NUH3	Depression	6A70-6A7Z	Approved	[426]
Colchicine	DM2POTE	Acute gout flare	FA25.0	Approved	[426]
Sulindac	DM2QHZU	Acute myelogenous leukaemia	2A41	Approved	[426]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[426]
Penicillamine	DM40EF6	Cystinuria	5C60.2	Approved	[426]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[426]

Drug(s) Affected By Aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Hydrogen peroxide	DM1NG5W	Infectious disease	1A00-CA43.1	Approved	[427]
Simvastatin	DM30SGU	Arteriosclerosis	BD40	Approved	[228]
Omeprazole	DM471KJ	Cystic fibrosis	CA25	Approved	[53]
Tretinoin	DM49DUI	Acne vulgaris	ED80	Approved	[253]
Hydroquinone	DM6AVR4	Melasma	ED60.1	Approved	[133]
Leflunomide	DMR8ONJ	Arthritis	FA20	Approved	[96]
Ciclosporin	DMAZJFX	Graft-versus-host disease	4B24	Approved	[97]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[216]
Temozolomide	DMKECZD	Adenocarcinoma	2D40	Approved	[200]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]

Drug(s) Affected By Ataxin-3 (ATXN3)

Drug Name	Drug ID	Indication	ICD 11	Highest Status	REF
Quercetin	DM3NC4M	Obesity	5B81	Approved	[112]
Aluminium	DM6ECN9	Hyperhidrosis	EE00	Approved	[428]
Valproate	DMCFE9I	Epilepsy	8A60-8A68	Approved	[114]
Demecolcine	DMCZQGK	Solid tumour/cancer	2A00-2F9Z	Approved	[99]
Cupric Sulfate	DMP0NFQ	Fungal infection	1F29-1F2F	Approved	[137]
Decitabine	DMQL8XJ	Acute myelogenous leukaemia	2A41	Approved	[429]
Cisplatin	DMRHGI9	Adenocarcinoma	2D40	Approved	[138]
Cocaine	DMSOX7I	Anaesthesia	9A78.6	Approved	[430]
Doxorubicin	DMVP5YE	Acute myelogenous leukaemia	2A41	Approved	[175]
Tocopherol	DMBIJZ6	N. A.	N. A.	Phase 2	[118]

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Fatty aldehyde dehydrogenase (ALDH3A2)	TTB6UM0	AL3A2_HUMAN	Inhibitor	[4]
COVID-19 papain-like proteinase (PL-PRO)	TTNHMO8	R1AB_SARS2 (819-2763)	Inhibitor	[2]
MERS-CoV papain-like proteinase (PL-PRO)	TTYJOLE	R1AB_CVEMC (854-2740)	Inhibitor	[3]
SARS-CoV papain-like proteinase (PL-PRO)	TTRGHB2	R1AB_CVHSA (819-2740)	Inhibitor	[3]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Substrate	[5]
Cytochrome P450 2E1 (CYP2E1)	DEVDYN7	CP2E1_HUMAN	Substrate	[6]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Substrate	[7]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)	OTHF4H9U	DHI2_HUMAN	Gene/Protein Processing	[8]
6-phosphogluconate dehydrogenase, decarboxylating (PGD)	OTVG296F	6PGD_HUMAN	Gene/Protein Processing	[9]
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Gene/Protein Processing	[10]
Aldehyde dehydrogenase 1A1 (ALDH1A1)	OTCUWZKB	AL1A1_HUMAN	Gene/Protein Processing	[11]
Aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1)	OTAYZZE6	AL3A1_HUMAN	Regulation of Drug Effects	[12]
Aldehyde dehydrogenase, mitochondrial (ALDH2)	OTKJ9I3N	ALDH2_HUMAN	Gene/Protein Processing	[13]
Aldo-keto reductase family 1 member B1 (AKR1B1)	OTRX72TH	ALDR_HUMAN	Gene/Protein Processing	[9]
Aldo-keto reductase family 1 member B10 (AKR1B10)	OTOA4HTH	AK1BA_HUMAN	Gene/Protein Processing	[9]
Aldo-keto reductase family 1 member C1 (AKR1C1)	OTQKR4CM	AK1C1_HUMAN	Gene/Protein Processing	[9]
Aldo-keto reductase family 1 member C3 (AKR1C3)	OTU2SXBA	AK1C3_HUMAN	Gene/Protein Processing	[9]

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